Atomization liquid, atomization liquid preparation method, and electronic atomization device

Abstract

Embodiments of the present application provide an atomization liquid. The atomization liquid comprises: nicotine, cytisine and a solvent. By using cytisine that acts synergistically with nicotine, the atomization liquid that provides better satisfaction and has a better tobacco addiction relief effect is provided without increasing the dosage of nicotine.

Description

Atomized liquid, atomized liquid preparation method, and electronic atomization device

[0001] This application claims priority to the Chinese patent application filed with the China Patent Office on November 24, 2023, with application number 202311586681.X, and invention name “A kind of atomizing liquid, a method for preparing atomizing liquid and an electronic atomizing device”, the entire contents of which are incorporated by reference into this application. Technical Field

[0002] The embodiments of the present application relate to the field of aerosol liquid, and in particular to an aerosol liquid containing nicotine and cytisine. Background Art

[0003] As a substitute for traditional cigarettes, e-cigarettes contain the physiologically active substance nicotine in their aerosol. Users inhale nicotine by smoking e-cigarettes, thereby creating a physiological satisfaction similar to that of smoking traditional cigarettes.

[0004] Based on local regulatory policies, limits have been placed on the nicotine content in e-cigarette atomizers. For example, the EU stipulates that the nicotine content in e-cigarette oil shall not exceed 20 mg / ml. Therefore, compared with traditional cigarettes, the existing e-cigarette atomizers are still not very ideal in terms of relieving smoking addiction. The vast majority of traditional cigarette consumers have reported that e-cigarettes cannot give them a better or similar sense of satisfaction than traditional cigarettes, and cannot provide sufficient strength and a fast and long-lasting nicotine intake experience, resulting in a low conversion rate of traditional tobacco consumers to new e-cigarette consumers. Therefore, under the premise of meeting the nicotine content limit, providing an e-cigarette atomizer with a good smoking experience and addiction relief, so as to be comparable to the nicotine intake satisfaction of traditional cigarettes, has become a technical problem that needs to be solved in this field. Summary of the Invention

[0005] In order to provide an electronic cigarette atomizing liquid with a good smoking experience and a high degree of addiction relief, an embodiment of the present application provides an atomizing liquid, which includes: nicotine, cytisine and a solvent.

[0006] In the aerosol liquid provided in one embodiment of the present application, the mass fraction of nicotine in the aerosol liquid is 0.50%-3.00%.

[0007] In the atomized liquid provided in one embodiment of the present application, the mass fraction of cytisine is 0.50%-5.00%.

[0008] In the atomized liquid provided in one embodiment of the present application, the mass fraction of the solvent is 50.00%-99.90%.

[0009] In the aerosol liquid provided in one embodiment of the present application, the mass fraction of nicotine is 1.00%-2.00%.

[0010] In the atomized liquid provided in one embodiment of the present application, the mass fraction of cytisine is 1.00%-4.00%.

[0011] In the atomized liquid provided in one embodiment of the present application, cytisine includes the free base of cytisine.

[0012] In the atomized liquid provided in one embodiment of the present application, cytisine includes cytisine salt.

[0013] In the atomized liquid provided in one embodiment of the present application, the cytisine salt is produced by the reaction of cytisine with an organic acid, and the organic acid is selected from one or more of formic acid, acetic acid, propionic acid, butyric acid, α-furanic acid, α-furanylbutyric acid, isovaleric acid, β-methylvaleric acid, levulinic acid, lactic acid, citric acid, malic acid, tartaric acid, succinic acid, oxalic acid, maleic acid, glycolic acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, benzoic acid, phenylacetic acid, caffeic acid, coumaric acid, phthalic acid and terephthalic acid.

[0014] The atomized liquid provided in one embodiment of the present application further includes a sweetener, and the mass fraction of the sweetener is 0.01%-0.60%.

[0015] In the atomized liquid provided in one embodiment of the present application, the sweetener includes one or a combination of neotame, cyclamate, sucralose, aspartame, steviol glycosides, acesulfame potassium and mogroside.

[0016] The atomized liquid provided in one embodiment of the present application further includes a cooling agent, and the mass fraction of the cooling agent is 0.10%-8.00%.

[0017] In the atomized liquid provided in one embodiment of the present application, the cooling agent includes one or a combination of menthol, menthone, isomenthone, 2-isopropyl-N,2,3-trimethylbutyramide, N-ethyl-p-menthyl-3-carboxamide and N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide.

[0018] The atomized liquid provided in one embodiment of the present application further includes a flavor composition, and the mass fraction of the flavor composition is 1.00%-20.00%.

[0019] In the atomizing liquid provided in one embodiment of the present application, the solvent includes one or a mixture of propylene glycol, butylene glycol, 1,2,4-butanetriol, dipropylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol 200, polyethylene glycol 400, triacetin, glycerol, dipropylene glycol ether, ethanol, water, triethyl citrate and caprylic acid glyceride.

[0020] One embodiment of the present application further provides a method for preparing an atomized liquid, comprising:

[0021] Weigh nicotine, cytisine and solvent according to a certain weight ratio;

[0022] adding cytisine to the solvent, stirring, and dissolving to obtain a first mixture;

[0023] adding nicotine to the first mixture and stirring to obtain a second mixture;

[0024] The second mixture was filtered to obtain an atomized liquid.

[0025] In the method for preparing the atomized liquid provided in one embodiment of the present application, in the process of adding cytisine to a solvent, stirring, and dissolving to obtain a first mixture, a sweetener and a cooling agent are also added to the solution.

[0026] In a method for preparing an atomized liquid provided in one embodiment of the present application, in the process of adding nicotine to a first mixture and stirring to obtain a second mixture, the flavor composition is also added to the first mixture.

[0027] An embodiment of the present application further provides an electronic atomization device, comprising the atomizing liquid provided in the above embodiment and an atomizer, wherein the atomizer is used to heat and atomize the atomizing liquid to generate an aerosol.

[0028] The present application provides an atomizing liquid, a method for preparing the atomizing liquid, and an electronic atomizing device, which use cytisine, which has a synergistic effect with nicotine, to provide an atomizing liquid with a better sense of satisfaction and a better effect of relieving smoking addiction without increasing the amount of nicotine. BRIEF DESCRIPTION OF THE DRAWINGS

[0029] One or more embodiments are exemplarily illustrated by pictures in the corresponding drawings. These exemplifications do not constitute limitations on the embodiments. Elements with the same reference numerals in the drawings are represented as similar elements. Unless otherwise stated, the figures in the drawings do not constitute proportional limitations.

[0030] FIG1 is a comparison chart of addiction relief scores of Examples 1-3 and Comparative Example 1 of the present application;

[0031] FIG2 is a comparison chart of addiction relief scores of Examples 4-6 and Comparative Example 2 of the present application;

[0032] FIG3 is a comparison chart of addiction relief scores of Example 7 and Comparative Example 3 of the present application;

[0033] FIG4 is a comparison chart of addiction relief scores of Example 8 and Comparative Example 4 of the present application;

[0034] FIG5 is a comparison chart of the addiction relief scores of Examples 9-11 and Comparative Example 5 of the present application. DETAILED DESCRIPTION

[0035] In order to facilitate the understanding of the present application, the present application is described in more detail below with reference to the accompanying drawings and specific implementation methods.

[0036] Obviously, the described embodiments are only part of the embodiments of this application, not all of the embodiments. Based on the embodiments in this application, all other embodiments obtained by ordinary technicians in this field without making creative work are within the scope of protection of this application.

[0037] References herein to "embodiments" mean that a particular feature, structure, or characteristic described in connection with the embodiments may be included in at least one embodiment of the present application. The appearance of this phrase in various places in the specification does not necessarily refer to the same embodiment, nor does it constitute an independent or alternative embodiment that is mutually exclusive of other embodiments. It is understood, both explicitly and implicitly, by those skilled in the art that the embodiments described herein may be combined with other embodiments.

[0038] One embodiment of the present application provides an atomized liquid comprising nicotine, cytisine, and a solvent. Cytisine, which has a synergistic effect with nicotine, provides an atomized liquid with a greater sense of satisfaction and a better effect in relieving smoking cravings without increasing the amount of nicotine used.

[0039] In one embodiment of the present application, the mass fraction of nicotine in the atomized liquid is 0.50%-3.00%.

[0040] In one embodiment of the present application, the mass fraction of cytisine is 0.50%-5.00%.

[0041] In one embodiment of the present application, the mass fraction of the solvent is 50.00%-99.90%.

[0042] Nicotine is a key component of e-cigarette liquid and can exist in free base or salt form. Early e-cigarettes generally used nicotine free base. Volatile nicotine free base is highly irritating and has a strong throat hit. It is primarily absorbed through the mouth and throat, making it difficult to enter the lungs. This results in a smaller amount entering the lungs, resulting in a poorer vaping experience. The use of nicotine salts has further advanced e-cigarettes. Because nicotine salts are less volatile and cause less throat irritation, the smoke becomes smoother after using nicotine salts, allowing more aerosol to enter the lungs for absorption, thereby improving the vaping experience.

[0043] The molecular formula of cytisine is C 11 H 14 N 2O Cytisine, also known as cytisine and urocanine in Chinese, is a natural bioactive compound first isolated from the flower of the genus Cytisus by Husemann and Marme in 1865. It is primarily found in plants of the Fabaceae family, such as Sophora flavescens, Sophora flavescens, and Sophora alopecuroides. Cytisine has a high affinity for neuronal nicotinic acetylcholine receptors, with specificity for the α-subtype, making it a partial agonist. Modern research has shown that cytisine has a variety of pharmacological effects, including smoking cessation, enhanced myocardial contractility, respiratory stimulation, antidepressant effects, dopamine neurotransmission, enhanced motor function, improved cognitive function, analgesia, and anti-tumor effects. Although isolated only a little over a century ago, cytisine's medical use dates back thousands of years, with Native Americans consuming cytisine seeds for emetic and purgative effects. In traditional European medicine, alcoholic extracts containing cytisine are used to treat constipation, migraines, insomnia, coughs, and neuralgia. About 100 years ago, it was used as an antiasthmatic and insecticide. By 1964, cytisine was developed into a smoking cessation drug and widely marketed in Central and Eastern Europe. Clinical studies have demonstrated its efficacy and safety. During World War II, when tobacco was in short supply, Russian soldiers smoked cytisine leaves as a tobacco substitute. Studies have shown that cytisine has a high affinity for the α-cytisine subtype of the nicotinic acetylcholine receptor and is a low nonspecific partial agonist.

[0044] The purpose of this application is to utilize the synergistic effect of cytisine, a partial agonist of nicotine acetylcholine, on nicotine, so that electronic cigarette liquid has better puff satisfaction and higher addiction relief without increasing the nicotine dosage, so as to better meet the needs of consumers who have a smoking alternative; using cytisine to partially replace nicotine to achieve a synergistic and effective comprehensive experience, reduce nicotine dosage, and use a low-dose nicotine electronic atomization liquid to achieve the satisfaction of the usual dose (20mg / ml) of electronic atomization liquid on the market, thereby reducing nicotine exposure, further reducing the addictiveness and health hazard risks of electronic cigarettes, and making electronic cigarettes a more effective smoking substitute and smoking cessation tool.

[0045] The components of the atomized liquid in some embodiments and comparative examples of the present application are shown in Tables 1-2. The components of the atomized liquid in Tables 1 and 2 are all calculated based on mass fractions.

[0046] The above-mentioned examples and comparative examples were loaded into the same electronic atomizer, and professional vapers conducted a comprehensive sensory quality evaluation from multiple dimensions, including atomized smoke volume, aroma quality, sweetness, cooling sensation, irritation, headiness, and lasting effect. Among them, irritation, headiness, and lasting effect are related to the addiction relief of the atomized liquid. The specific evaluation indicators are shown in Table 3.

[0047] Table 1 Components of the atomized liquid in each embodiment and comparative example

[0048] Table 2 Components of the atomized liquid in each embodiment and comparative example

[0049] Table 3 Comprehensive sensory evaluation index of atomized liquid

[0050] According to the above sensory evaluation standards, seven professional tasters conducted sensory evaluation on the above examples and comparative examples. Each sample was evaluated three times, and the results were averaged. The obtained scores are shown in Table 4.

[0051] Table 4 Sensory evaluation of the atomized liquid in each embodiment and comparative example

[0052] As shown in Figures 1-5, in Comparative Example 1 and Examples 1-3, the mass fraction of nicotine was 1.80%, the mass fraction of cytisine increased from 0 to 3.00%, and 15.00% mango flavor was added to the flavor composition. It can be seen that in the mango-flavored atomized liquid, the craving relief of the atomized liquid increased significantly with the increase in the mass fraction of cytisine. In Comparative Example 2 and Examples 4-6, the mass fraction of nicotine was 1.60%, the mass fraction of cytisine increased from 0 to 2.80%, and the flavor composition consisted of 2.00% tobacco extract and 12.00% tobacco flavor. It can be seen that in the tobacco-flavored atomized liquid, the craving relief of the atomized liquid increased significantly with the increase in the mass fraction of cytisine. In Example 7 and Comparative Example 3, the mass fraction of nicotine was 3.00%, the mass fraction of cytisine increased from 0 to 2.50%, and the flavor composition was blueberry flavor. It can be seen that in the blueberry-flavored aerosol liquid, the craving relief of the aerosol liquid increased significantly with the increase in the mass fraction of cytisine. In Comparative Example 4 and Example 8, the mass fraction of nicotine was 0.50%, the mass fraction of cytisine increased from 0 to 5.00%, and the flavor composition was 13.00% grape flavor. It can be seen that in the grape-flavored aerosol liquid, the craving relief of the aerosol liquid increased significantly with the increase in the mass fraction of cytisine. In Comparative Example 5 and Examples 9-11, the mass fraction of nicotine was reduced from 2.00% to 1.00%, and the mass fraction of cytisine was increased from 0 to 4.00%. The addiction relief effect of the atomized liquid was still maintained at a certain level. It can be seen that increasing the cytisine content while reducing the nicotine content and replacing part of the nicotine with cytisine can achieve a synergistic and effective comprehensive experience.

[0053] As shown in Table 3, when the mass fraction of nicotine in Example 8 is increased from 0.50%, the scores of the irritation, high feeling, and lasting effect of the atomized liquid are 2.86, 2.71, and 2.07, respectively. In Example 11, the mass fraction of nicotine is 1.00%, and the scores of the irritation, high feeling, and lasting effect of the atomized liquid are 4.25, 3.32, and 3.12, respectively, indicating that the addiction relief of the atomized liquid is significantly improved. In addition, the EU stipulates that the nicotine content in electronic cigarettes is less than 2.00%. Therefore, in some embodiments of the present application, the mass fraction of nicotine in the atomized liquid is 1.00%-2.00%, and the addiction relief of the atomized liquid is relatively high.

[0054] In some embodiments of the present application, the mass fraction of cytisine is 1.00%-5.00%. Within this range, while the mass fraction of nicotine remains constant, increasing the mass fraction of cytisine significantly improves the addiction relief of the aerosolized liquid. Therefore, cytisine and nicotine have a synergistic effect in improving addiction relief.

[0055] In some embodiments of the present application, the mass fraction of cytisine is 1.00%-4.00%. Referring to Comparative Example 5 and Examples 9-11, when the mass fraction of nicotine is between 1.00% and 2.00%, the mass fraction of nicotine is reduced, and cytisine is used to replace part of the nicotine. At this time, the mass fraction of cytisine is between 1.00% and 4.00%, which can maintain the addiction relief of the atomized liquid at a certain level. That is, cytisine can be used to partially replace nicotine to achieve a synergistic and comprehensive experience, reduce the amount of nicotine used, and achieve the satisfaction of the usual dose (20mg / ml) of electronic atomized liquid on the market with a low dose of nicotine, thereby reducing nicotine exposure, further reducing the addictiveness and health risks of electronic cigarettes, and making electronic cigarettes a more effective smoking cessation tool.

[0056] In some embodiments of the present application, the mass fraction of cytisine is 1.00%-3.00%. Referring to Comparative Example 1 and Examples 1-3, when nicotine is at a preset value, the addiction relief of the atomized liquid is significantly improved as the mass fraction of cytisine increases from 1.00% to 3.00%, demonstrating a significant synergistic effect of cytisine and nicotine on addiction relief.

[0057] In some embodiments of the present application, cytisine includes the free base of cytisine.

[0058] In some embodiments of the present application, cytisine includes cytisine salts.

[0059] In some embodiments of the present application, the cytisine salt is formed by reacting cytisine with an organic acid, and the organic acid is selected from one or more combinations of formic acid, acetic acid, propionic acid, butyric acid, α-furanic acid, α-furanylbutyric acid, isovaleric acid, β-methylvaleric acid, levulinic acid, lactic acid, citric acid, malic acid, tartaric acid, succinic acid, oxalic acid, maleic acid, glycolic acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, benzoic acid, phenylacetic acid, caffeic acid, coumaric acid, phthalic acid and terephthalic acid.

[0060] In some embodiments of the present application, the atomized liquid further includes a sweetener, and the mass fraction of the sweetener is 0.01%-0.60%.

[0061] In some embodiments of the present application, the sweetener includes one or a combination of neotame, cyclamate, sucralose, aspartame, steviol glycosides, acesulfame potassium and mogroside.

[0062] In some embodiments of the present application, the atomized liquid further includes a cooling agent, and the mass fraction of the cooling agent is 0.10%-8.00%.

[0063] In some embodiments of the present application, the cooling agent includes one or a combination of menthol, menthone, isomenthone, WS-23 (2-isopropyl-N,2,3-trimethylbutyramide), WS-3 (N-ethyl-p-menthyl-3-carboxamide) and WS-5 (N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide).

[0064] In some embodiments of the present application, the atomized liquid further includes a flavor composition, and the mass fraction of the flavor composition is 1.00%-20.00%.

[0065] In some embodiments of the present application, the atomized liquid further includes a flavor composition, and the mass fraction of the flavor composition is 10.00%-15.00%.

[0066] In some embodiments of the present application, the solvent includes one or a mixture of propylene glycol, butylene glycol, 1,2,4-butanetriol, dipropylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol 200, polyethylene glycol 400, triacetin, glycerol, dipropylene glycol ether, ethanol, water, triethyl citrate and glyceryl caprylate.

[0067] In some embodiments of the present application, the added amounts of the sweetener, cooling agent, and flavor composition can be determined according to user needs and are not limited to the amounts and types provided in this specification.

[0068] One embodiment of the present application further provides a method for preparing an atomized liquid, comprising:

[0069] Weigh nicotine, cytisine and solvent according to a certain weight ratio;

[0070] adding cytisine to the solvent, stirring, and dissolving to obtain a first mixture;

[0071] adding nicotine to the first mixture and stirring to obtain a second mixture;

[0072] The second mixture was filtered to obtain an atomized liquid.

[0073] In some embodiments of the present application, in the process of adding cytisine to a solvent, stirring, and dissolving to obtain a first mixture, a sweetener and a cooling agent are further added to the solution.

[0074] In some embodiments of the present application, the process of adding nicotine to the first mixture and stirring to obtain the second mixture further includes adding a flavor composition to the first mixture.

[0075] In some embodiments of the present application, in the process of filtering the second mixture to obtain the atomized liquid, 80-120 mesh filter cloth is used for filtration.

[0076] In some embodiments of the present application, a method for preparing an atomized liquid is provided, comprising:

[0077] Weighing nicotine, cytisine, a sweetener, a cooling agent, a flavor composition, and a solvent according to a certain weight ratio;

[0078] Adding the sweetener, cooling agent, and cytisine to the solvent, stirring, and dissolving to obtain a first mixture;

[0079] adding nicotine and flavor composition to the first mixture and stirring to obtain a second mixture;

[0080] The second mixture was filtered through a filter cloth having 80-120 meshes to obtain an atomized liquid.

[0081] One embodiment of the present application further provides an electronic atomization device, comprising the atomizing liquid provided in the above embodiment and an atomizer, the atomizer being configured to atomize the atomizing liquid to generate an aerosol. In some examples, the atomizer may employ a heating element utilizing resistive heating, electromagnetic induction heating, infrared radiation heating, or microwave heating; in other examples, the atomizer may employ a high-frequency vibration element to atomize the atomizing liquid to form aerosol particles, such as an ultrasonic atomizer.

[0082] It should be noted that the specification and drawings of this application provide preferred embodiments of the present application, but are not limited to the embodiments described in this specification. Furthermore, it is possible for a person skilled in the art to make improvements or changes based on the above description, and all such improvements and changes should fall within the scope of protection of the claims attached to this application.

Claims

1. An atomized liquid, characterized in that: The atomized liquid comprises nicotine, cytisine and a solvent.

2. The atomized liquid according to claim 1, characterized in that: The mass fraction of the nicotine in the atomized liquid is 0.50%-3.00%.

3. The atomized liquid according to claim 1, characterized in that: The mass fraction of cytisine is 0.50%-5.00%.

4. The atomized liquid according to claim 1, characterized in that: The mass fraction of the solvent is 50.00%-99.90%.

5. The atomized liquid according to claim 1, characterized in that: The mass fraction of the nicotine is 1.00%-2.00%.

6. The atomized liquid according to claim 1, characterized in that: The mass fraction of cytisine is 1.00%-4.00%.

7. The atomized liquid according to claim 1, characterized in that: The cytisine includes the free base of cytisine.

8. The atomized liquid according to claim 1, characterized in that: The cytisine includes cytisine salts.

9. The atomized liquid according to claim 8, characterized in that: The cytisine salt is generated by the reaction of cytisine with an organic acid, wherein the organic acid is selected from one or a combination of formic acid, acetic acid, propionic acid, butyric acid, α-furanoic acid, α-furanomethylbutyric acid, isovaleric acid, β-methylvaleric acid, levulinic acid, lactic acid, citric acid, malic acid, tartaric acid, succinic acid, oxalic acid, maleic acid, glycolic acid, lauric acid, myristic acid, palmitic acid, stearic acid, oleic acid, linoleic acid, linolenic acid, benzoic acid, phenylacetic acid, caffeic acid, coumaric acid, phthalic acid and terephthalic acid.

10. The atomized liquid according to claim 1, characterized in that: The invention also comprises a sweetener, wherein the mass fraction of the sweetener is 0.01%-0.60%.

11. The atomized liquid according to claim 10, characterized in that: The sweetener includes one or a combination of neotame, cyclamate, sucralose, aspartame, steviol glycosides, acesulfame potassium and mogroside.

12. The atomized liquid according to claim 1, characterized in that: The invention also comprises a cooling agent, wherein the mass fraction of the cooling agent is 0.10%-8.00%.

13. The atomized liquid according to claim 12, characterized in that: The cooling agent includes one or a combination of menthol, menthone, isomenthone, 2-isopropyl-N,2,3-trimethylbutyramide, N-ethyl-p-menthyl-3-carboxamide and N-(ethoxycarbonylmethyl)-p-alkane-3-carboxamide.

14. The atomized liquid according to claim 1, characterized in that: Also included is a flavor composition, wherein the mass fraction of the flavor composition is 1.00%-20.00%.

15. The atomized liquid according to claim 1, characterized in that: The solvent includes one or a mixture of propylene glycol, butylene glycol, 1,2,4-butanetriol, dipropylene glycol, diethylene glycol, triethylene glycol, polyethylene glycol 200, polyethylene glycol 400, triacetin, glycerol, dipropylene glycol ether, ethanol, water, triethyl citrate and caprylic acid glyceride.

16. A method for preparing an atomized liquid, comprising: Weigh nicotine, cytisine and solvent according to a certain weight ratio; Adding the cytisine to the solvent, stirring, and dissolving to obtain a first mixture; adding the nicotine to the first mixture and stirring to obtain a second mixture; The second mixture is filtered to obtain the atomized liquid.

17. The atomized liquid according to claim 16, characterized in that The process of adding the cytisine into the solvent, stirring, and dissolving to obtain the first mixture also includes adding a sweetener and a cooling agent into the solution.

18. The atomized liquid according to claim 16, characterized in that: The process of adding the nicotine to the first mixture and stirring to obtain the second mixture also includes adding a flavor composition to the first mixture.

19. An electronic atomization device, comprising an atomizer and the atomizing liquid according to any one of claims 1 to 15, wherein the atomizer is used to atomize the atomizing liquid to generate an aerosol.

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