Cryosurgery device for endoscope

Abstract

The present invention relates to a cryosurgery device for an endoscope, the cryosurgery device being characterized by comprising: a needle having a needle cooling unit which is cooled by a refrigerant and cools a target; a cooling nozzle that is detachably attached to the endoscope and is inserted into the needle and sprays the needle cooling unit with the refrigerant; and an insulation member that is provided in one area of the outer circumference of the needle other than the needle cooling unit and insulates the needle.

Description

Endoscopic cooling surgical device

[0001] The present invention relates to a cooling surgical device compatible with an endoscope.

[0002] Medical treatments based on cryoablation (Cryonecrosis) are commonly used to kill cancer cells, and their effectiveness has been proven through various case studies and research results.

[0003] Among them, the target is cooled by opening the abdomen or inserting a cooling needle from the outside to perform a cryotherapy treatment on the target of the internal organ.

[0004] The main structure of the cooling needle applied to cooling death is to install a nozzle inside the needle, and to inject a refrigerant at high pressure through this nozzle to cool the tip and wall of the needle.

[0005] However, in the case of cryopreservation treatment using conventional cold needles, the conventional cold needles may cause damage to cells in unwanted areas due to the laparotomy or external insertion method, and in particular, the laparotomy method has the problem of being a great burden to the patient.

[0006] In the case of cancer cells that are located inside the body, such as the pancreas, and are difficult to treat with medication, there is also the problem of making treatment very difficult.

[0007] Accordingly, when a needle is inserted from outside the human body and the needle is cooled, there is a problem of causing cooling death of unwanted normal cells due to heat transfer from the cooled area of ​​the needle.

[0008] In addition, there is a problem that the distance between the conventional control unit, the refrigerant supply hose, and the cooling needle is long, so the method for improving cooling performance is limited, and it is also difficult to perform the control.

[0009] Accordingly, the present applicant has developed an endoscopic cryosurgery device that can be used with an endoscopic device and that cools and kills only cells in a target area without damaging normal cells through insertion of an endoscope, using a needle cooled by a refrigerant.

[0010] The present invention is intended to solve the above-mentioned problems, and the purpose of the present invention is to provide an endoscopic cooling surgical device that can be used with an endoscopic device and that is compatible with a needle cooled by a refrigerant, and that provides an insulating member in an area of ​​the needle that comes into contact with normal cells to prevent the death of normal cells and cool and kill only cells in a target area, and that can improve the precision of a procedure through insertion of an endoscope.

[0011] In addition, another object of the present invention is to provide an endoscopic cooling surgical device that can control the cooling performance of a needle and perform a procedure by selectively mounting cooling nozzles of various sizes according to the treatment area of ​​the target area by attaching and detaching a needle and a cooling nozzle inserted into the needle to an endoscope.

[0012] The problems to be solved by the present invention are not limited to the problems mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the description below.

[0013] The object of the present invention can be achieved by an endoscopic cooling surgical device, which comprises, as one embodiment of the present invention, a needle having a needle cooling unit that is cooled by a refrigerant and cools a target; a cooling nozzle that is detachably attached to an endoscope and inserted into the needle to spray a refrigerant to the needle cooling unit; and a heat insulating member that is provided on an outer peripheral region of the needle excluding the needle cooling unit to provide heat insulation.

[0014] Here, the needle of the endoscopic cooling surgical device according to one embodiment of the present invention may include a needle body forming a passage therein; and a needle cooling unit extending from one end of the needle body to form a chamber communicating with the passage and cooled by a refrigerant to puncture and cool a target, and the cooling nozzle may include a refrigerant supply passage through which refrigerant is supplied; an injection unit that injects refrigerant flowing along the refrigerant supply passage into a chamber of the needle cooling unit; a needle coupling unit to which the needle is detachably coupled; and an endoscope detachable unit that is detachably coupled to an endoscope.

[0015] An endoscopic cooling surgical device according to one embodiment of the present invention further includes one or more refrigerant discharge holes formed through the needle body to discharge the refrigerant introduced into the needle cooling unit, and the insulating member may be provided between the needle cooling unit and the refrigerant discharge holes.

[0016] In an endoscopic cooling surgical device according to one embodiment of the present invention, a flow path through which a refrigerant flows is formed between the passage of the needle and the outer circumference of the cooling nozzle, and the refrigerant supplied to the refrigerant supply path of the cooling nozzle can pass through the chamber of the needle and the flow path and be discharged through the refrigerant discharge hole.

[0017] Meanwhile, an endoscopic cooling surgical device according to another embodiment of the present invention may include a needle having a needle cooling unit that is cooled by a refrigerant and cools a target; a cooling nozzle that is inserted into the needle and sprays a refrigerant to the needle cooling unit; a refrigerant discharge pipe that penetrates the cooling nozzle and is detachably coupled to the needle, and through which the refrigerant that cooled the needle cooling unit flows so as to be discharged to the outside of the endoscope; an endoscope attachment / detachment portion that clamps a joint portion of the refrigerant discharge pipe and the needle and is detachable from the endoscope; and an insulating member that is provided on an outer peripheral region of the needle between the needle cooling unit and the endoscope attachment / detachment portion and provides thermal insulation.

[0018] In another embodiment of the present invention, the needle of the endoscopic cooling surgical device comprises: a needle body forming a passage therein; and a needle cooling unit extending from one end of the needle body to form a chamber communicating with the passage, the needle cooling unit being cooled by a refrigerant and puncturing and cooling a target; the cooling nozzle comprises: a refrigerant supply passage through which refrigerant is supplied; and an injection unit for injecting refrigerant flowing along the refrigerant supply passage into a chamber of the needle cooling unit; and the refrigerant discharge pipe may include: a nozzle coupling hole through which the cooling nozzle penetrates; a needle coupling portion coupled to the other end of the needle; and one or more refrigerant discharge holes through which refrigerant that has cooled the needle cooling portion is discharged.

[0019] In another embodiment of the present invention, an endoscopic cooling surgical device is provided, wherein a flow path through which a refrigerant flows is formed between the passage of the needle and the outer circumference of the cooling nozzle, and a refrigerant discharge path is formed between the outer circumference of the cooling nozzle and the inner circumference of the refrigerant discharge pipe, communicating with the flow path and through which the refrigerant is discharged, and the refrigerant supplied to the refrigerant supply path of the cooling nozzle can be discharged through the chamber of the needle, the flow path, and the refrigerant discharge path, and then through the refrigerant discharge hole.

[0020] Meanwhile, the needle cooling unit of the endoscopic cooling surgical device according to the present invention may have a step with respect to the outer periphery of the needle body, and may include a stopper that prevents the insulating member from moving toward the tip of the needle cooling unit.

[0021] The tip of the above needle cooling unit can be formed to be inclined at an angle of 40 to 70 degrees with respect to the central axis of the needle.

[0022] The device may further include a refrigerant supply pipe connecting a refrigerant supply source and the cooling nozzle and supplying refrigerant to the cooling nozzle; and a refrigerant supply valve provided in the refrigerant supply pipe and controlling the flow of refrigerant supplied to the cooling nozzle.

[0023] The above refrigerant supply valve is turned on or off and the refrigerant supply pipe is opened or closed to control the flow rate of refrigerant supplied to the needle, and the opening and closing time of the refrigerant supply valve can be controlled to control the cooling length and temperature of the needle.

[0024] The above refrigerant supply pipe may further include a pressure and temperature control unit that controls the pressure and temperature of the refrigerant supplied from the refrigerant supply source to the needle.

[0025] The above pressure and temperature control unit can control the pressure of the refrigerant supplied from the refrigerant supply source to the needle to control the flow rate and temperature of the refrigerant supplied to the needle, and can include a temperature control system independent of the pressure control.

[0026] According to the present invention, a needle cooled by a refrigerant can be used in an endoscopic device and is compatible with it. By providing an insulating member in the area of ​​the needle that comes into contact with normal cells, the death of normal cells is prevented and only cells in the target area are cooled and killed. In addition, the burden on the human body during the procedure can be reduced and precision can be improved through insertion of an endoscope.

[0027] In addition, by attaching and detaching the needle and the cooling nozzle inserted into the needle to the endoscope, the cooling performance of the needle can be adjusted and the treatment can be performed by selecting and attaching cooling nozzles of various sizes according to the treatment area of ​​the target area.

[0028] The effects of the present invention are not limited to the effects mentioned above, and other effects not mentioned will be clearly understood by those skilled in the art from the description below.

[0029] Figure 1 is a configuration diagram of an endoscopic cooling surgical device according to one embodiment of the present invention;

[0030] Fig. 2 is a perspective view of the needle assembly of Fig. 1;

[0031] Figure 3 is an exploded perspective view of Figure 2.

[0032] Figure 4 is a cross-sectional view of Figure 2;

[0033] Figure 5 is an enlarged cross-sectional view of the main part of Figure 4 showing the flow of refrigerant;

[0034] Figure 6 is an exploded perspective view of a needle assembly according to another embodiment of the present invention;

[0035] Fig. 7 is a cross-sectional view of Fig. 6 showing the flow of refrigerant;

[0036] Figure 8 is a drawing showing the result of performing a cooling death procedure on a target area using the endoscopic cooling surgery device of Figure 1.

[0037] The advantages and features of the present invention, and the methods for achieving them, will become clearer with reference to the embodiments described in detail below together with the accompanying drawings. However, the present invention is not limited to the embodiments disclosed below and may be implemented in various different forms. These embodiments are provided solely to ensure that the disclosure of the present invention is complete and to fully inform those skilled in the art of the scope of the present invention, and the present invention is defined solely by the scope of the claims.

[0038] The terminology used herein is for the purpose of describing embodiments only and is not intended to limit the present invention. In this specification, the singular also includes the plural unless specifically stated otherwise. As used herein, the terms "comprises" and / or "comprising" do not exclude the presence or addition of one or more other components in addition to the mentioned components. Like reference numerals refer to like components throughout the specification, and "and / or" includes each and any combination of one or more of the mentioned components. Although "first", "second", etc. are used to describe various components, these components are not limited by these terms. These terms are only used to distinguish one component from another. Therefore, it should be understood that a first component mentioned below may also be a second component within the technical spirit of the present invention.

[0039] Unless otherwise defined, all terms (including technical and scientific terms) used herein may be used in their common sense to those skilled in the art to which the present invention pertains. Furthermore, terms defined in commonly used dictionaries are not to be interpreted ideally or excessively unless explicitly and specifically defined otherwise.

[0040] Hereinafter, embodiments of the present invention will be described in detail with reference to the attached drawings.

[0041] Before the explanation, in several embodiments, elements having the same configuration will be described representatively in one embodiment using the same symbols, and in other embodiments, elements having a different configuration from one embodiment will be described.

[0042] FIG. 1 illustrates an endoscopic cooling surgical device according to one embodiment of the present invention.

[0043] As illustrated in FIG. 1, an endoscopic cooling surgical device (1) according to one embodiment of the present invention includes a needle assembly (10) for puncturing a target area and a coolant supply unit (100) for supplying coolant to the needle assembly (10).

[0044] The needle assembly (10) includes a needle (20) having a needle cooling unit (31) that is cooled by a refrigerant and cools a target, as shown in FIGS. 2 to 5, a cooling nozzle (40) that is detachably coupled to an endoscope (200) and inserted into the needle (20) to spray a refrigerant to the needle cooling unit (31), and an insulating member (60) that is provided on an outer peripheral area of ​​the needle (20) excluding the needle cooling unit (31) to provide insulation.

[0045] The needle (20) includes a needle body (21) and a needle cooling unit (31).

[0046] The needle body (21) has a hollow cylinder shape of a certain length. Inside the needle body (21), a passage (23) of a certain diameter is formed along the central axis of the needle body (21).

[0047] The needle cooling unit (31) extends from one end of the needle body (21) and has a tip shape like an arrowhead to effectively concentrate cooling on the target area. In addition, the needle cooling unit (31) may have shapes such as wings, holes, and porous structures on the inside or outside to increase the heat transfer efficiency and expand the heat exchange area. This needle cooling unit (31) also serves to puncture the target area with the needle (20). Here, the needle cooling unit (31) may include a needle tip, and the tip of the needle cooling unit (31) may be formed at an angle of 40 to 70 degrees with respect to the central axis of the needle (20).

[0048] In addition, a chamber (33) is formed inside the needle cooling unit (31) that communicates with the passage (23) of the needle body (21). Accordingly, when a coolant is introduced into the chamber (33) of the needle cooling unit (31) to cool and kill the target area, the needle cooling unit (31) is cooled by the coolant and can cool the target area.

[0049] In addition, the needle cooling unit (31) includes a stopper (35) having a step with the outer periphery of the needle body (21). In this way, by providing the stopper (35) in the needle cooling unit (31), it is possible to prevent the insulating member (60) mounted on the outer periphery of the needle body (21) from moving toward the tip of the needle cooling unit (31).

[0050] The cooling nozzle (40) has a hollow rod shape of a certain length and is inserted into the passage (23) of the needle body (21) to spray and supply refrigerant to the chamber (33) of the needle cooling unit (31).

[0051] The cooling nozzle (40) includes a refrigerant supply path (41), an injection part (43), a needle coupling part (45), and an endoscope attachment / detachment part (47).

[0052] The refrigerant supply path (41) is formed to have a constant diameter and penetrate the inside of the cooling nozzle (40) along the central axis of the cooling nozzle (40).

[0053] At the tip of the cooling nozzle (40) facing the needle cooling unit (31), an injection unit (43) is provided for injecting the refrigerant flowing along the refrigerant supply path (41) into the chamber (33) of the needle cooling unit (31). Here, a separate injection nozzle may be mounted at the tip of the cooling nozzle.

[0054] In addition, on the outer periphery of the cooling nozzle (40) located on the opposite side of the injection unit (43), a needle coupling portion (45) is provided, which forms a step having an outer diameter larger than the outer diameter of the cooling nozzle (40), and to which a needle (20) is detachably coupled. The needle (20) and the needle coupling portion (45) can be screw-coupled.

[0055] In this way, the needle (20) and the needle joint (45) are screw-jointed, so that not only can the needle (20) and the cooling nozzle (40) be easily mounted, but also the diameter of the cooling nozzle (40) can be selected according to the treatment area of ​​the target area, thereby controlling the cooling performance of the needle (20) and the flow rate of the coolant supplied to the needle (20).

[0056] And, on the outer periphery of the cooling nozzle (40) adjacent to the needle coupling portion (45), an endoscope attachment portion (47) that is detachably coupled to an endoscope (200) is provided. The endoscope attachment portion (47) forms a step with an outer diameter greater than the outer diameter of the needle coupling portion (45), and the endoscope attachment portion (47) has a fitting groove (49) formed with a predetermined depth, into which the endoscope (200) is pressed and fitted.

[0057] And, at the end of the cooling nozzle (40) located on the opposite side of the injection unit (43), a barb fitting (51) to which a refrigerant supply pipe (120) to be described later is connected is provided.

[0058] The Dean heat insulating member (60) is provided in an outer peripheral area of ​​the needle body (21) between the needle cooling section (31) and the needle connecting section (45), and insulates the needle body (21).

[0059] That is, the insulating member (60) blocks the cooling heat generated in the needle body (21) from being transferred to the outside of the needle body (21).

[0060] The insulating member (60) has a hollow pipe shape of a certain length.

[0061] The inner diameter of the insulating member (60) has the same size as the outer diameter of the needle body (21). Meanwhile, it is preferable that the outer diameter of the insulating member (60) is smaller than the maximum outer diameter of the needle cooling unit (31) and smaller than the outer diameter of the endoscope attachment / detachment unit (47).

[0062] In this way, by providing the insulating member (60), it is possible to prevent the death of normal cells coming into contact with the needle body (21) and to cool and kill only the cells in the target area. Furthermore, it is possible to control the cooling area of ​​the needle (20) by adjusting the length of the insulating member (60) according to the treatment area of ​​the target area.

[0063] Here, the insulating member (60) may be made of an aerogel material.

[0064] Meanwhile, an endoscopic cooling surgical device (1) according to one embodiment of the present invention includes a pair of refrigerant discharge holes (25) formed through a needle body (21) to discharge refrigerant introduced into the needle cooling unit (31) to the outside of the needle (20).

[0065] Here, the refrigerant discharge holes (25) may be provided in pairs and may be provided facing each other on the needle body (21), but this is not limited to this, and one or more refrigerant discharge holes (25) may be provided.

[0066] Meanwhile, an insulating member (60) may be provided between the needle cooling unit (31) and the refrigerant discharge hole (25).

[0067] By this configuration, as shown in FIGS. 4 and 5, when a cooling nozzle (40) is inserted into the passage (23) of the needle (20) and the needle (20) is screw-connected to the needle connecting portion (45) of the cooling nozzle (40), a flow path (55) through which the refrigerant flows is formed between the passage (23) of the needle (20) and the outer circumference of the cooling nozzle (40).

[0068] Next, an insulating member (60) is installed on the outer periphery of the needle body (21) so that the refrigerant discharge hole (25) is exposed. At this time, the refrigerant discharge hole (25) is positioned so as to be exposed to the outside of the human body or a location where the refrigerant can be safely discharged.

[0069] Accordingly, the refrigerant supplied from the refrigerant supply unit (100) described later flows into the chamber (33) of the needle cooling unit (31) through the refrigerant supply path (41) of the cooling nozzle (40), as shown in FIG. 5, cools the needle cooling unit (31), and then is discharged to the outside of the needle (20) through the refrigerant discharge hole (25) through the flow path (55).

[0070] Meanwhile, the needle cooling unit (31) is cooled to a temperature below zero by the coolant introduced into the chamber (33), thereby cooling and killing the target area around the needle cooling unit (31), and the coolant that cooled the needle cooling unit (31) in the chamber (33) of the needle cooling unit (31) flows along the flow path (55) and is discharged to the outside of the human body through the coolant discharge hole (25). Meanwhile, the cooling heat transferred to the needle body (21) by the cooling nozzle (40) and the residual heat of the coolant discharged along the flow path (55) to the coolant discharge hole (25) are not transferred to the outside of the needle body (21) by the insulating member (60), so that the outside temperature of the insulating member (60) is maintained at a temperature exceeding 0°C, for example, an image temperature, so that during the cooling and killing procedure, the normal cell area located around the needle (20) except for the area around the needle cooling unit (31) is not cooled and killed.

[0071] Here, the length of the insulating member (60) and the position of the refrigerant discharge hole (25) can be adjusted in response to the location of the target area for the cooling death treatment and the treatment area. In addition, although the present embodiment describes that the refrigerant discharge hole (25) is provided to be exposed so that the refrigerant is discharged around the needle body (21), the present invention is not limited thereto, and a refrigerant recovery pipe, not shown so as not to expose the refrigerant discharge hole (25), can be coupled to the needle body (21) so that the refrigerant discharged through the refrigerant discharge hole (25) can be recovered through the refrigerant recovery pipe.

[0072] In addition, the endoscopic cooling surgical device (1) according to one embodiment of the present invention may further include a refrigerant supply unit (100) for supplying refrigerant to the needle assembly (10).

[0073] The refrigerant supply unit (100) may further include a refrigerant supply pipe (120) and a refrigerant supply valve (130).

[0074] The refrigerant supply pipe (120) connects the refrigerant supply source (110) and the cooling nozzle (40), and supplies refrigerant to the refrigerant supply path (41) of the cooling nozzle (40). Here, the refrigerant of the refrigerant supply source (110) may be medical liquid carbon dioxide. In addition, the refrigerant supply pipe (120) may be a flexible hose.

[0075] The refrigerant supply valve (130) is provided in the refrigerant supply pipe (120) and controls the flow of refrigerant supplied to the refrigerant supply path (41) of the cooling nozzle (40).

[0076] For example, the refrigerant supply valve (130) is controlled by an on or off control method to open or close the refrigerant supply pipe (120), thereby controlling the flow rate of the refrigerant supplied to the needle (20), thereby reducing the amount of refrigerant used, and also controlling the opening and closing time of the refrigerant supply valve (130) to control the cooling temperature of the needle (20).

[0077] In addition, the refrigerant supply valve (130) can supply refrigerant in a step control manner to effectively concentrate cooling on the needle cooling unit (31).

[0078] Here, a solenoid valve may be provided as a refrigerant supply valve (130).

[0079] In addition, the endoscopic cooling surgical device (1) according to one embodiment of the present invention may further include a pressure and temperature control unit (140).

[0080] A pressure and temperature control unit (140) is provided in the refrigerant supply pipe (120), preferably in the refrigerant supply pipe (120) between the refrigerant supply source (110) and the refrigerant supply valve (130), to control the pressure and temperature of the refrigerant supplied from the refrigerant supply source (110) to the needle (20).

[0081] The pressure and temperature control unit (140) controls the pressure of the refrigerant supplied from the refrigerant supply source (110) to the needle (20), thereby controlling the flow rate and temperature of the refrigerant supplied to the needle (20). Here, as one embodiment, the pressure and temperature control unit (140) may be provided as a pressure reducing valve.

[0082] Meanwhile, the pressure and temperature control unit (140) can control the temperature of the refrigerant supplied from the refrigerant supply source (110) to the needle (20) through a chiller, Peltier, etc. as an example of a temperature control module (not shown) as well as the pressure reduction of the refrigerant through a pressure reducing valve as another embodiment.

[0083] Accordingly, the cooling method of the needle (20) of the endoscopic cooling surgical device (1) according to one embodiment of the present invention can use the Joule-Thomson effect, which is a temperature reduction effect due to the decompression of the refrigerant, or can adopt a method in which the temperature of the supplied refrigerant is low.

[0084] Accordingly, the endoscopic cooling surgical device (1) according to one embodiment of the present invention can control the flow rate of the refrigerant supplied to the needle (20) through the refrigerant supply valve (130), and can also control the decompression of the refrigerant and the temperature of the refrigerant through the pressure and temperature control unit (140).

[0085] As an example, in order to check the change in the temperature of the refrigerant supplied to the nozzle according to the degree of pressure reduction of the pressure and temperature control unit (140), the external temperature of the pressure and temperature control unit (140) was measured, and when the refrigerant supplied from the refrigerant supply source (110) at 55 bar was reduced to 30 bar in the pressure and temperature control unit (140), the temperature could drop to 5°C to 10°C, and when the pressure was reduced to 20 bar, the temperature could drop to -6°C to -10°C.

[0086] Meanwhile, a process of supplying medical liquid carbon dioxide refrigerant at a pressure of 55 bar, reducing the pressure to 20 to 30 bar in a pressure and temperature control unit (140), cooling the refrigerant, connecting a needle assembly (10) in which a cooling nozzle (40) with a diameter of 0.4 mm, a needle (20), and an insulating member (60) are assembled, and supplying the refrigerant reduced in pressure and temperature control unit (140) through the refrigerant supply pipe (120) to the needle assembly (10) to perform a cooling death treatment is briefly described.

[0087] First, as an example, as shown in Fig. 1, a needle (20) is inserted through the stomach wall into the target area.

[0088] At this time, the insulating material mounted on the needle is positioned in the area of ​​normal cells excluding the target area, and the refrigerant discharge hole (25) of the needle (20) is positioned so that it is exposed inside the stomach.

[0089] Next, the refrigerant is decompressed to 30 bar in the pressure and temperature control unit (140) for 50 seconds, the refrigerant supply valve (130) is opened, and the decompressed refrigerant is supplied to the chamber (33) of the needle cooling unit (31) through the cooling nozzle (40) to cool the needle cooling unit (31).

[0090] At this time, the refrigerant that cooled the needle cooling unit (31) is discharged to the outside of the human body through the refrigerant discharge hole (25) along the flow path (55) formed between the needle (20) and the cooling nozzle (40).

[0091] Next, the refrigerant is further decompressed to 20 bar in the pressure and temperature control unit (140) for 180 seconds, thereby reducing the refrigerant temperature to -5°C to -10°C, and the refrigerant supply valve (130) is opened to supply the further decompressed refrigerant through the cooling nozzle (40) to the chamber (33) of the needle cooling unit (31), thereby cooling the needle cooling unit (31), and cooling and killing the cells of the target area by the cooling heat of the needle cooling unit (31).

[0092] At this time, the refrigerant that cooled the needle cooling unit (31) is discharged to the outside of the human body through the refrigerant discharge hole (25) along the flow path (55) formed between the needle (20) and the cooling nozzle (40).

[0093] Then, after closing the refrigerant supply valve (130) for 70 seconds to stop cooling of the needle cooling unit (31), the needle (20) is removed from the target area to end the procedure.

[0094] At this time, after the cooling of the needle (20) is stopped for 70 seconds after the cooling treatment, the needle (20) is withdrawn from the target area, so that the cooling-killed cells in the target area are frozen and not torn off.

[0095] Meanwhile, FIG. 8 is a drawing showing the result of performing a cooling death procedure on a target area of ​​the liver of a living pig for 5 minutes using an endoscopic cooling surgery device (1) according to the present invention.

[0096] As shown in Figure 8, cell death due to cooling can be confirmed up to about 3 mm from the needle wall.

[0097] In addition, as shown in Fig. 8, cooling is concentrated in the front, and it can be confirmed that cell death progresses widely in the target area that is the object of cooling, and there is almost no death in normal cells above where the needle is inserted due to the insulation.

[0098] Meanwhile, FIGS. 6 and 7 illustrate another embodiment of a needle assembly applied to an endoscopic cooling surgical device according to the present invention.

[0099] The needle assembly (10') according to another embodiment has a different structure from the needle assembly described above.

[0100] A needle assembly (10') according to another embodiment, unlike the needle assembly described above, includes a refrigerant discharge pipe (70) that is removably coupled to a needle (20) and through which a cooling nozzle (40) is penetrated, and an endoscope attachment / detachment portion (90) that clamps the joint portion of the refrigerant discharge pipe (70) and the needle (20) and is removably attached / detachable to an endoscope (200).

[0101] The refrigerant discharge pipe (70) has a hollow pipe shape with one side open, and the refrigerant that cooled the needle cooling unit (31) flows so that it is discharged to the outside of the endoscope.

[0102] The refrigerant discharge pipe (70) includes a nozzle coupling hole (71) through which a cooling nozzle (40) penetrates and is coupled, a needle coupling portion (73) coupled to the other end of a needle (20), and one or more refrigerant discharge holes (75) through which refrigerant that has cooled the needle cooling portion (31) is discharged.

[0103] The nozzle coupling hole (71) is formed to penetrate in the direction of the central axis of the refrigerant discharge pipe (70), and the cooling nozzle (40) is arranged concentrically with the refrigerant discharge pipe (70).

[0104] The needle coupling portion (73) can be coupled to a barb fitting provided at the other end of the needle (20) so that the refrigerant discharge pipe (70) does not easily come off from the needle (20) due to the high pressure of the refrigerant.

[0105] Additionally, the refrigerant discharge hole (75) of the refrigerant discharge pipe (70) can be positioned on the outside of the endoscope (200).

[0106] Additionally, a refrigerant discharge path (77) is formed between the outer circumference of the refrigerant discharge pipe (70) and the outer circumference of the cooling nozzle (40), which communicates with the flow path (55) and through which the refrigerant is discharged.

[0107] Accordingly, the needle assembly (10') has a structure in which the needle (20) is arranged concentrically with the cooling nozzle (40) at one end of the cooling nozzle (40), and the refrigerant discharge pipe (70) is arranged concentrically with the cooling nozzle (40) at the other end of the cooling nozzle (40).

[0108] The endoscope attachment / detachment part (90) has a sleeve shape and clamps the joint portion of the refrigerant discharge pipe (70) and the needle (20).

[0109] By this configuration, as shown in FIGS. 6 and 7, the needle coupling portion (73) of the refrigerant discharge pipe (70) is coupled to the other end of the needle (20).

[0110] Then, the joint portion of the refrigerant discharge pipe (70) and the needle (20) is clamped with the endoscope attachment / detachment portion (90).

[0111] Next, when the cooling nozzle (40) is inserted into the passage (23) of the needle (20) by penetratingly connecting the cooling nozzle (40) to the nozzle coupling hole (71) of the refrigerant discharge pipe (70), a flow path (55) through which the refrigerant flows is formed between the passage (23) of the needle (20) and the outer circumference of the cooling nozzle (40), and a refrigerant discharge path (77) through which the refrigerant is discharged is formed between the outer circumference of the cooling nozzle (40) and the inner circumference of the refrigerant discharge pipe (70) and is in communication with the flow path (55).

[0112] And, an insulating material (60) is mounted on the outer periphery of the needle body (21) between the needle cooling unit (31) and the endoscope attachment / detachment unit (90).

[0113] Accordingly, the refrigerant supplied from the refrigerant supply unit (100) flows into the chamber (33) of the needle cooling unit (31) through the refrigerant supply path (41) of the cooling nozzle (40), as shown in FIG. 6, cools the needle cooling unit (31), and then is discharged to the outside of the needle (20) through the refrigerant discharge hole (75) through the flow path (55) and the refrigerant discharge path (77).

[0114] Meanwhile, the needle cooling unit (31) is cooled to a sub-zero temperature by the refrigerant introduced into the chamber (33), thereby cooling and killing the target area around the needle cooling unit (31), and the refrigerant that cooled the needle cooling unit (31) in the chamber (33) of the needle cooling unit (31) flows along the flow path (55) and the refrigerant discharge path (77) and is discharged to the outside of the human body through the refrigerant discharge hole (75). Meanwhile, the cooling heat transferred to the needle body (21) by the cooling nozzle (40) and the residual heat of the refrigerant discharged along the flow path (55) to the refrigerant discharge hole (75) are not transferred to the outside of the needle body (21) by the insulating member (60), so that the temperature outside the insulating member (60) is maintained at the temperature of the image, and during the cooling and killing procedure, the normal cell area located around the needle (20) except for the area around the needle cooling unit (31) is not cooled and killed.

[0115] In this way, according to the present invention, a needle cooled by a refrigerant can be used in an endoscopic device and a heat insulating member is provided in the area of ​​the needle that comes into contact with normal cells, thereby preventing the death of normal cells and cooling and killing only cells in the target area, thereby improving the precision of the procedure through insertion of the endoscope.

[0116] In addition, by attaching and detaching the needle and the cooling nozzle inserted into the needle to the endoscope, it is possible to control the cooling performance of the needle and perform the procedure by selecting and attaching cooling nozzles of various sizes according to the treatment area of ​​the target area.

[0117] While the embodiments of the present invention have been described above with reference to the attached drawings, those skilled in the art will appreciate that the present invention can be implemented in other specific forms without altering the technical spirit or essential features thereof. Therefore, the embodiments described above should be understood to be illustrative in all respects and not restrictive.

Claims

1. A needle having a needle cooling section that is cooled by a refrigerant and cools the target; A cooling nozzle that is detachable from the endoscope and inserted into the needle to spray refrigerant to the needle cooling unit; and An endoscopic cooling surgical device, comprising an insulating member provided on an outer peripheral area of ​​the needle excluding the needle cooling unit for insulating the needle.

2. In paragraph 1, The above needle, a needle body forming a passage inside; and The needle cooling unit comprises a chamber extending from one end of the needle body and communicating with the passage, and is cooled by a refrigerant to puncture and cool the target. The above cooling nozzle, A refrigerant supply line through which refrigerant is supplied; An injection unit for injecting refrigerant flowing along the refrigerant supply path into a chamber of the needle cooling unit; A needle joint to which the needle is detachably connected; and An endoscopic refrigeration surgical device comprising an endoscope detachable portion attachable to an endoscope.

3. In paragraph 2, It further includes one or more refrigerant discharge holes formed through the needle body to discharge the refrigerant introduced into the needle cooling unit. An endoscopic cooling surgical device, wherein the above-mentioned insulating member is provided between the needle cooling unit and the refrigerant discharge port.

4. In paragraph 3, A flow path through which refrigerant flows is formed between the passage of the needle and the outer circumference of the cooling nozzle. An endoscopic cooling surgical device, wherein the refrigerant supplied to the refrigerant supply passage of the above cooling nozzle passes through the chamber of the above needle and the above flow passage and is discharged through the above refrigerant discharge hole.

5. A needle having a needle cooling unit that is cooled by a refrigerant and cools the target; A cooling nozzle inserted into the needle and spraying refrigerant into the needle cooling section; A refrigerant discharge pipe through which the cooling nozzle is penetratingly coupled and detachably coupled to the needle, and through which the refrigerant that has cooled the needle cooling unit flows so as to be discharged to the outside of the endoscope; An endoscope attachment / detachment part that clamps the joint portion of the above refrigerant discharge pipe and the above needle and is attached / detachable to the endoscope; and An endoscopic cooling surgical device, comprising a heat insulating member provided on an outer peripheral region of the needle between the needle cooling unit and the endoscope attachment / detachment unit for heat insulation.

6. In paragraph 5, The above needle, a needle body forming a passage inside; and The needle cooling unit comprises a chamber extending from one end of the needle body and communicating with the passage, and is cooled by a refrigerant to puncture and cool the target. The above cooling nozzle, A refrigerant supply line through which refrigerant is supplied; and It includes a spray unit that sprays refrigerant flowing along the refrigerant supply path into the chamber of the needle cooling unit, The above refrigerant discharge pipe, A nozzle joining hole through which the above cooling nozzle penetrates and joins; A needle coupling portion coupled to the other end of the needle; and An endoscopic refrigeration surgical device comprising one or more refrigerant discharge holes through which refrigerant that has cooled the needle cooling unit is discharged.

7. In paragraph 6, A flow path through which refrigerant flows is formed between the passage of the needle and the outer circumference of the cooling nozzle. A refrigerant discharge path is formed between the outer circumference of the cooling nozzle and the inner circumference of the refrigerant discharge pipe, which communicates with the flow path and through which the refrigerant is discharged. An endoscopic cooling surgical device, wherein the refrigerant supplied to the refrigerant supply passage of the above cooling nozzle passes through the chamber of the needle, the flow passage, and the refrigerant discharge passage and is discharged through the refrigerant discharge hole.

8. In paragraph 2 or paragraph 6, An endoscopic cooling surgical device, wherein the needle cooling unit has a step with respect to the outer periphery of the needle body and includes a stopper that prevents the insulating member from moving toward the tip of the needle cooling unit.

9. In paragraph 1 or paragraph 5, An endoscopic cooling surgical device, wherein the tip of the needle cooling unit is formed with holes formed on the outside and inside, or wings formed, or a porous shape formed to increase heat transfer efficiency.

10. In paragraph 1 or paragraph 5, A refrigerant supply pipe connecting a refrigerant supply source and the cooling nozzle, and supplying refrigerant to the cooling nozzle; and An endoscopic refrigeration surgical device further comprising a refrigerant supply valve provided in the refrigerant supply pipe to control the flow of refrigerant supplied to the cooling nozzle.

11. In paragraph 10, The above refrigerant supply valve is turned on or off and the refrigerant supply pipe is opened or closed to control the flow rate of refrigerant supplied to the needle, and the opening and closing time of the refrigerant supply valve is controlled to control the cooling length and temperature of the needle. An endoscopic cooling surgical device.

12. In paragraph 10, An endoscopic refrigeration surgical device further comprising a pressure and temperature control unit provided in the refrigerant supply pipe to control the pressure and temperature of refrigerant supplied from the refrigerant supply source to the needle.

13. In paragraph 12, The above pressure and temperature control unit controls the pressure and temperature of the refrigerant supplied from the refrigerant supply source to the needle, thereby controlling the flow rate and temperature of the refrigerant supplied to the needle. An endoscopic refrigeration surgical device.

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