Anti-acne and Anti-inflammatory composition comprising sulfated schizophyllan and use thereof

Abstract

An anti-acne and anti-inflammatory composition comprising sulfated schizophyllan and use thereof. The anti-acne and anti-inflammatory composition comprising sulfated schizophyllan comprises sulfated schizophyllan, a kapok extract, an Aloe Barbadensis gel, and panthenol. The composition has the effects of diminishing inflammation, removing acne, improving microcirculation, lightening acne scars and pigmentation spots, promoting skin metabolism, hydrating and moisturizing, regulating water-oil balance, repairing damaged skin, and strengthening skin barrier.

Description

An acne-removing and anti-inflammatory composition containing sulfated schizophyllan and its application

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This disclosure claims priority to Chinese patent application No. 202311690655.1 filed with the State Intellectual Property Office of China on December 8, 2023, entitled “An acne-removing and anti-inflammatory composition containing sulfated schizophyllan and its application,” the entire contents of which are incorporated herein by reference. Technical Field

[0003] The present disclosure belongs to the technical field of cosmetics and relates to an anti-acne and anti-inflammatory composition containing sulfated schizophyllan and applications thereof. Background Art

[0004] At all ages, the skin barrier can be damaged for various reasons, including increased oil secretion during adolescence; hormonal and endocrine imbalances caused by excessive work stress; and UV damage in daily life. This can lead to an imbalance in water and oil secretion, resulting in acne-prone skin. Acne scars typically take about a month to fade through normal basal metabolism. With aging, basal metabolism decreases significantly, and the reduced metabolic rate of skin cells can lead to persistent localized acne scars and increased pigmentation on the face. Therefore, to fundamentally address this skin problem, skincare products should not only have anti-inflammatory and acne-removing properties but also promote microcirculation, accelerate skin cell metabolism, and activate cells, thereby preventing acne scars and increased pigmentation. How to improve skin cell metabolism to eliminate acne scars, fade pigmentation, reduce pigmentation formation, and improve the damaged skin barrier in acne-prone skin is a skin problem that needs to be addressed in this field.

[0005] Summary of the Invention

[0006] In view of the shortcomings of the prior art, the present invention aims to provide an acne-removing and anti-inflammatory composition containing sulfated Schizophyllan and its application.

[0007] To achieve this disclosure purpose, the present disclosure adopts the following technical solutions:

[0008] In a first aspect, the present disclosure provides an acne-removing and anti-inflammatory composition containing sulfated schizophyllan, wherein the acne-removing and anti-inflammatory composition containing sulfated schizophyllan comprises sulfated schizophyllan, kapok flower extract, aloe vera gel, and panthenol.

[0009] Sulfated schizophyllan is obtained by schizophyllan through sulfate modification. It has good moisturizing properties and anticoagulant effects. It can not only replenish water and moisturize, but also effectively reduce blood viscosity, unclog blood vessels, and improve blood microcirculation, thereby improving skin metabolism.

[0010] Kapok flower extract is obtained from the flowers of the Kapok plant of the Bombaxceae family. It contains oligosaccharides, flavonoids, organic acids, sterols, triterpenes, coumarins, etc. It has certain antibacterial and anti-inflammatory effects, can effectively reduce shedding, inhibit sebum production, and thus achieve the effect of anti-inflammatory and acne removal.

[0011] Aloe vera gel is extracted from the natural herb aloe vera. Its natural ingredients are highly pure and have no side effects. It is highly effective in treating and caring for various skin problems and minor everyday injuries. It has a strong bactericidal effect on purulent skin conditions such as pustules and folliculitis, with rapid results. Aloe vera gel is also rich in antioxidants. Amino acids and peptides can effectively promote the production of collagen and elastic fibers in the dermis, thereby improving skin toughness and elasticity, firming the skin, and refining pores. It has the benefits of preventing skin sagging, hydrating, moisturizing, whitening, and removing freckles.

[0012] Provitamin B5 (panthenol) has the ability to improve the skin barrier, repair and stabilize, soothe and moisturize, and promote wound healing. It can strengthen the skin barrier and reduce irritation. Panthenol can also soothe skin with atopic dermatitis, ichthyosis, psoriasis, or contact dermatitis. Panthenol has a small molecular weight and can effectively penetrate the stratum corneum, infiltrating the stratum corneum on the skin's surface. It has a strong moisturizing effect, effectively improving skin roughness, making it soft and non-sticky. It also stimulates epithelial cell growth, accelerates epidermal wound healing, and repairs tissue trauma.

[0013] Preferably, the acne-removing and anti-inflammatory composition containing sulfated Schizophyllan comprises, by mass, 0.1-5 parts of sulfated Schizophyllan, 0.1-4 parts of kapok extract, 10-20 parts of aloe vera gel, and 10-20 parts of panthenol.

[0014] The mass fraction of the sulfated schizophyllan can be selected from 0.1 parts, 0.2 parts, 0.4 parts, 0.6 parts, 0.8 parts, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, 2.2 parts, 2.4 parts, 2.6 parts, 2.8 parts, 3 parts, 3.2 parts, 3.4 parts, 3.6 parts, 3.8 parts, 4 parts, 4.2 parts, 4.4 parts, 4.6 parts, 4.8 parts, 5 parts, etc. The mass fraction of the kapok flower extract can be selected from 0.1 parts, 0.2 parts, 0.4 parts, 0.6 parts, 0.8 parts, 1 part, 1.2 parts, 1.4 parts, 1.6 parts, 1.8 parts, 2 parts, 2.2 parts, 2.4 parts, 2.6 parts, 2.8 parts, 3 parts, 3.2 parts, 3.4 parts, 3.6 parts, 3.8 parts, 4 parts, etc. The mass fraction of aloe gel can be selected from 10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts, 15 parts, 15.5 parts, 16 parts, 16.5 parts, 17 parts, 17.5 parts, 18 parts, 18.5 parts, 19 parts, 19.5 parts, 20 parts, etc., and the mass fraction of panthenol can be selected from 10 parts, 10.5 parts, 11 parts, 11.5 parts, 12 parts, 12.5 parts, 13 parts, 13.5 parts, 14 parts, 14.5 parts, 15 parts, 15.5 parts, 16 parts, 16.5 parts, 17 parts, 17.5 parts, 18 parts, 18.5 parts, 19 parts, 19.5 parts, 20 parts, etc. Other specific values ​​within the above numerical range can be selected, which will not be repeated here.

[0015] In a second aspect, the present disclosure provides a use of the anti-acne and anti-inflammatory composition containing sulfated Schizophyllan according to the first aspect in the preparation of cosmetics.

[0016] Preferably, the cosmetics include lotion, facial mask, essence or essence cream.

[0017] Preferably, the mass fraction of the acne-removing and anti-inflammatory composition containing sulfated schizophyllan in the cosmetic is 1-5 parts, for example, 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc. Other specific point values ​​within the above numerical range can be selected and will not be repeated here.

[0018] In a third aspect, the present disclosure provides an acne-removing and anti-inflammatory facial mask containing sulfated Schizophyllan, the facial mask comprising a facial mask base and a facial mask essence, the facial mask base comprising non-woven cotton, and the facial mask essence comprising the acne-removing and anti-inflammatory composition containing sulfated Schizophyllan described in the first aspect, a moisturizer, a thickener, and water.

[0019] Preferably, the facial mask essence comprises, by mass, 1-5 parts of the anti-acne and anti-inflammatory composition containing sulfated Schizophyllan described in the first aspect, 5-10 parts of a moisturizer, 0.1-0.3 parts of a thickener, and water.

[0020] The mass fraction of the acne-removing and anti-inflammatory composition containing sulfated schizophyllan can be selected from 1 part, 1.5 parts, 2 parts, 2.5 parts, 3 parts, 3.5 parts, 4 parts, 4.5 parts, 5 parts, etc., the mass fraction of the moisturizer can be selected from 5 parts, 5.5 parts, 6 parts, 6.5 parts, 7 parts, 7.5 parts, 8 parts, 8.5 parts, 9 parts, 9.5 parts, 10 parts, etc., the mass fraction of the thickener can be selected from 0.1 parts, 0.12 parts, 0.14 parts, 0.16 parts, 0.18 parts, 0.2 parts, 0.22 parts, 0.24 parts, 0.26 parts, 0.28 parts, 0.3 parts, etc. Other specific point values ​​within the above numerical range can be selected, and they will not be repeated here.

[0021] Preferably, the moisturizing agent comprises any one or a combination of at least two of glycerin, butylene glycol, dipropylene glycol, sorbitol, trehalose or allantoin.

[0022] Preferably, the thickening agent comprises carbomer.

[0023] Preferably, the facial mask liquid further comprises a chelating agent and / or a preservative.

[0024] Preferably, the chelating agent comprises disodium EDTA.

[0025] Preferably, the preservative comprises phenoxyethanol-ethylhexylglycerin.

[0026] In a fourth aspect, the present disclosure provides a method for preparing the acne-removing and anti-inflammatory facial mask containing sulfated schizophyllan according to the third aspect, the method for preparing the facial mask comprising mixing a facial mask base with a facial mask essence to obtain;

[0027] The preparation method of the facial mask base comprises: sterilizing non-woven cotton to obtain;

[0028] The preparation method of the facial mask essence comprises: mixing a moisturizer, a thickener and water, and then mixing the mixture with the acne-removing and anti-inflammatory composition containing sulfated schizophyllan to obtain the facial mask essence.

[0029] Preferably, the time for mixing the mask base and the mask essence is 10-20 hours, for example, 10 hours, 11 hours, 12 hours, 13 hours, 14 hours, 15 hours, 16 hours, 17 hours, 18 hours, 19 hours, 20 hours, etc. Other specific point values ​​within the above numerical range can be selected, and they will not be repeated here.

[0030] Preferably, the temperature at which the moisturizer, thickener and water are mixed is 90-95°C, for example, 90°C, 91°C, 92°C, 93°C, 94°C, 95°C, etc. Other specific values ​​within the above numerical range can be selected and will not be described here one by one.

[0031] Preferably, the temperature for mixing with the anti-acne and anti-inflammatory composition containing sulfated schizophyllan is 40-45°C, for example, 40°C, 41°C, 42°C, 43°C, 44°C, 45°C, etc. Other specific values ​​within the above numerical range can be selected and will not be described here one by one.

[0032] Preferably, the moisturizing agent, thickener and water are mixed together with a chelating agent.

[0033] Preferably, the acne-removing and anti-inflammatory composition containing sulfated Schizophyllan is further mixed with a preservative.

[0034] Compared with the prior art, the present disclosure has the following beneficial effects:

[0035] The present invention discloses a multi-effect facial mask for removing acne, reducing inflammation, repairing, stabilizing, soothing and hydrating containing a sulfated schizophyllan composition, prepared by organically compounding sulfated schizophyllan and other active ingredients. The mask utilizes the anticoagulant activity of sulfated schizophyllan and the antibacterial and anti-inflammatory effects of kapok flower extract, combined with other active ingredients for synergistic enhancement, to reduce inflammation and remove acne, improve microcirculation, fade acne marks and spots, promote skin metabolism, hydrate and moisturize, regulate water-oil balance, repair skin damage, and strengthen the skin barrier, thereby achieving the effects of removing acne, reducing inflammation, repairing, stabilizing, soothing and hydrating. DETAILED DESCRIPTION

[0036] In order to further illustrate the technical means and effects adopted by the present disclosure, the technical solutions of the present disclosure are further described below in combination with the preferred embodiments of the present disclosure, but the present disclosure is not limited to the scope of the embodiments.

[0037] The sources of the functional ingredients contained in the products involved in the following embodiments, comparative examples, application examples, and comparative application examples are as follows (only the functional ingredients are reflected, and the necessary auxiliary ingredients contained in other commercially available raw materials are not repeated):

[0038] Schizophyllan was purchased from Emerald Switzerland under the trade name Schizophyllan;

[0039] Kapok flower extract was purchased from Shenzhen Yixin Biopharmaceutical Co., Ltd. under the trade name Kapok flower extract;

[0040] Carbomer was purchased from Zhaoheng Company under the trade name of Carbomer 940 thickener;

[0041] Aloe vera gel was purchased from Xi'an Wei'ao Biotechnology Co., Ltd. under the trade name of aloe vera gel.

[0042] Preparation Example 1

[0043] This preparation example provides a sulfated schizophyllan, and its preparation method is as follows: take 1g of dried schizophyllan, put it into a screw-mouth conical flask, add 150mL of DMF, and soak it in a dry environment for 12h. Add 4g of sulfur trioxide pyridine, react in a water bath at 70°C for 3h, and stir at a rate of 700rpm. After the reaction is completed, add 200mL of pre-cooled distilled water, adjust the pH value of the solution to 7.5 with 2mol / L NaOH, add 95% ethanol to a final ethanol concentration of 75% for alcohol precipitation, and redissolve the polysaccharide with distilled water. After dialyzing for 72h using an ultrafiltration membrane with a molecular weight cutoff of 30kD, concentrate under reduced pressure at 50°C, and freeze-dry to obtain sulfated schizophyllan S-SPG.

[0044] Example 1

[0045] This embodiment provides an acne-removing and anti-inflammatory composition containing sulfated schizophyllan, which comprises, by mass, 5 parts of sulfated schizophyllan, 4 parts of kapok flower extract, 15 parts of aloe vera gel, and 15 parts of panthenol.

[0046] The preparation method comprises the following steps: physically mixing sulfated schizophyllan, kapok flower extract, aloe vera gel and panthenol to obtain the product.

[0047] Example 2

[0048] This embodiment provides an acne-removing and anti-inflammatory composition containing sulfated schizophyllan, which comprises, by mass, 3 parts of sulfated schizophyllan, 2 parts of kapok flower extract, 12 parts of aloe vera gel, and 12 parts of panthenol.

[0049] The preparation method is as in Example 1.

[0050] Example 3

[0051] This embodiment provides an acne-removing and anti-inflammatory composition containing sulfated schizophyllan, which comprises, by mass, 1 part of sulfated schizophyllan, 1 part of kapok flower extract, 18 parts of aloe vera gel, and 18 parts of panthenol.

[0052] The preparation method is as in Example 1.

[0053] Comparative Example 1

[0054] This comparative example provides an acne-removing and anti-inflammatory composition containing sulfated schizophyllan, which differs from Example 1 only in that it does not contain sulfated schizophyllan, and its reduced mass is proportionally distributed to the mass of kapok flower extract, aloe vera gel and panthenol, while the other ingredients and contents remain unchanged.

[0055] The preparation method is as in Example 1.

[0056] Comparative Example 2

[0057] This comparative example provides an acne-removing and anti-inflammatory composition containing sulfated schizophyllan, which differs from Example 1 only in that it does not contain kapok flower extract, and its reduced mass is proportionally distributed to the mass of sulfated schizophyllan, aloe vera gel and panthenol, while the other ingredients and contents remain unchanged.

[0058] The preparation method is as in Example 1.

[0059] Comparative Example 3

[0060] This comparative example provides an acne-removing and anti-inflammatory composition containing sulfated schizophyllan, which differs from Example 1 only in that it does not contain aloe vera gel, and its reduced mass is proportionally distributed to the mass of sulfated schizophyllan, kapok extract and panthenol, while the other ingredients and contents remain unchanged.

[0061] The preparation method is as in Example 1.

[0062] Comparative Example 4

[0063] This comparative example provides an acne-removing and anti-inflammatory composition containing sulfated schizophyllan, which differs from Example 1 only in that it does not contain panthenol, and its reduced mass is proportionally distributed to the mass of sulfated schizophyllan, kapok flower extract, and aloe vera gel, while the other ingredients and contents remain unchanged.

[0064] The preparation method is as in Example 1.

[0065] Comparative Example 5

[0066] This comparative example provides an anti-acne and anti-inflammatory composition containing sulfated Schizophyllan, which differs from Example 1 only in that an equal amount of sulfated Schizophyllan is replaced by Schizophyllan, and other ingredients and contents remain unchanged.

[0067] The preparation method is as in Example 1.

[0068] Application Example 1

[0069] This application example provides an acne-removing and anti-inflammatory facial mask containing sulfated schizophyllan. The facial mask comprises a facial mask base and a facial mask essence. The facial mask base is non-woven cotton. The formula of the facial mask essence is as follows:

[0070] Its preparation method is:

[0071] (1) mixing a moisturizer, a thickener, a chelating agent, and water at 93° C., and then mixing the mixture with the composition of the present disclosure at 43° C. to obtain a first mixed solution;

[0072] (2) mixing the preservative, the pH adjuster and the first mixed solution at 42° C. to obtain a facial mask essence;

[0073] (3) Mix the mask base and the mask essence for 15 hours, and then package them separately. Add 20 mL of essence to each bag.

[0074] Application Example 2

[0075] This application example provides an acne-removing and anti-inflammatory facial mask containing sulfated schizophyllan. The facial mask comprises a facial mask base and a facial mask essence. The facial mask base is non-woven cotton. The formula of the facial mask essence is as follows:

[0076] Its preparation method is:

[0077] (1) mixing a moisturizer, a thickener, and a chelating agent at 90° C., and then mixing the mixture with the composition of the present disclosure at 40° C. to obtain a first mixed solution;

[0078] (2) mixing the preservative, the pH adjuster and the first mixed solution at 42° C. to obtain a facial mask essence;

[0079] (3) After mixing the mask base and the mask essence for 10 hours, separate the packs and add 20 mL of essence into each bag.

[0080] Application Example 3

[0081] This application example provides an acne-removing and anti-inflammatory facial mask containing sulfated schizophyllan. The facial mask comprises a facial mask base and a facial mask essence. The facial mask base is non-woven cotton. The formula of the facial mask essence is as follows:

[0082] Its preparation method is:

[0083] (1) mixing a moisturizer, a thickener, and a chelating agent at 95° C., and then mixing the mixture with the composition of the present disclosure at 45° C. to obtain a first mixed solution;

[0084] (2) mixing the preservative, the pH adjuster and the first mixed solution at 42° C. to obtain a facial mask essence;

[0085] (3) Mix the mask base and the mask essence for 20 hours, and then package them separately. Add 20 mL of essence to each bag.

[0086] Comparative Application Examples 1-5

[0087] This comparative application example provides five acne-removing and anti-inflammatory facial masks containing sulfated schizophyllan. The only difference between it and application example 1 is that the composition of example 1 in the facial mask essence is replaced with the compositions described in comparative examples 1-5 in equal amounts, and the other ingredients and contents remain unchanged.

[0088] The preparation method refers to Application Example 1.

[0089] Test Example 1

[0090] Acne removal effect test

[0091] The acne-removing and anti-inflammatory facial masks containing sulfated schizophyllan prepared in Example 1 to Example 3 and Comparative Examples 1 to 5 were evaluated for their acne-removing effects. The specific evaluation method is as follows:

[0092] (1) 80 volunteers aged 18 to 45 years with mild / moderate acne skin, accompanied by pigmentation, persistent erythema or depressed scars, who were able to maintain a regular lifestyle during the use period, were randomly divided into 8 groups, with 10 people in each group.

[0093] (2) Divide the face into two parts, with the left side as the test area and the right side as the control area. Use the test sample on the left side of the face and only use clean water to wipe the right side of the face. Use it continuously for 14 days.

[0094] (3) After 14 days, the total score was calculated using the evaluation items and corresponding scores in Table 1 to evaluate the acne removal effect. The acne removal effect was scored as the acne removal effect score on the left side of the face and the acne removal effect score on the right side of the face. The average value of each group was calculated. The results are shown in Table 2.

[0095] Table 1

[0096] Table 2

[0097] It can be seen from the data in Table 2 that the composition disclosed in the present invention has a good acne-removing effect, and the sulfated schizophyllan, kapok flower extract, aloe vera gel and panthenol have a certain synergistic effect in the above effect.

[0098] Test Example 2

[0099] 90 volunteers uniformly cleaned the flexed side of their left and right forearms and gently dried them with a paper towel. Ten people in each sample group participated in the test. Three areas of 4cm×4cm were marked as test areas for each person in each sample group, with at least 2cm between each area. The test results were statistically averaged. Before using the samples, the volunteers' test skin was thermally stimulated for 5 minutes with a hot hair dryer. Then, the test areas were smeared with an appropriate amount of the samples of Application Examples 1-3 and Comparative Application Examples 1-5. The control group did not use any samples. The changes in the hemoglobin content of the skin were recorded (the method was: data collection was arranged before and 30 minutes after the use of the samples. The skin parameters were collected each time using a skin testing instrument (CK Multifunctional Skin Tester CK MPA10), the skin hemoglobin content was statistically calculated, and the changes in the skin hemoglobin content after different application times were calculated. The results are shown in Table 3.

[0100] Hemoglobin content (%) = (hemoglobin content after 30 minutes of use / hemoglobin content before use) × 100%

[0101] Table 3

[0102] It can be seen from the data in Table 3 that the composition disclosed in the present invention has a good repairing effect, and the sulfated schizophyllan, kapok extract, aloe vera gel and panthenol have a certain synergistic effect in the above effect.

[0103] Test Example 3

[0104] Anti-inflammatory effect test

[0105] Test samples: Application Examples 1-3, Comparative Application Examples 1-5

[0106] Test method:

[0107] (1) Dilute the Raw264.7 cells in good culture to a concentration of 1×10 5 cfu / mL;

[0108] (2) Prepare a 12-well cell plate and add a concentration of 1×10 5 cfu / mL of Raw264.7 cells were transferred to a 12-well plate using a pipette, 1 mL was added to each well, and cultured at 37°C for 24 h;

[0109] (3) The experiment included 10 groups: a blank group (no sample added), an LPS group (1 μg / mL LPS added), an experimental group (2 mg / mL sample solutions of Application Examples 1-3 and Comparative Application Examples 1-5 added with 1 μg / mL LPS), and a positive control group (0.1 mg / mL dexamethasone added). The supernatant of the Raw264.7 cell culture medium was discarded, and the corresponding solution of each group was added, and the cells were incubated at 37°C for 24 h.

[0110] (4) The supernatant was aspirated and centrifuged. The concentrations of inflammatory factors TNF-α and IL-6 were detected according to the test steps on the ELISA kit. Each group was measured in parallel 5 times and the average value was taken. The results are shown in Table 4.

[0111] Table 4

[0112] As shown in Table 4, the composition of the present disclosure has a good anti-inflammatory effect, and the sulfated schizophyllan, kapok extract, aloe vera gel and panthenol have a synergistic effect in the above effect.

[0113] Test Example 4

[0114] Moisturizing effect test

[0115] 80 volunteers uniformly cleaned the curved side of their left and right forearms, and gently dried them with a paper towel. A total of 10 people in each sample group participated in the test. Each person in each sample group marked 3 areas of 4cm×4cm as test areas, with at least 2cm between each area. The test results were statistically averaged. Appropriate amounts of equal amounts of Application Examples 1-3 and Comparative Application Examples 1-5 samples were applied to the test areas. Data collection of the subjects was arranged before using the samples and 2 hours and 4 hours after use. Skin parameters were collected each time using a skin testing instrument (Corneometer CM825), and the growth rate (%) of the moisture content of the skin stratum corneum was calculated. Growth rate = (moisture content after n hours of use - moisture content before use) / moisture content before use. The results are shown in Table 5.

[0116] Table 5

[0117] As shown in Table 5, the composition of the present disclosure has a good moisturizing effect, and the sulfated schizophyllan, kapok flower extract, aloe vera gel and panthenol have a synergistic effect in the above effect.

[0118] Test Example 5

[0119] Security Testing

[0120] The facial masks of Application Examples 1-3 and Comparative Application Examples 1-5 were subjected to skin irritation testing. Eighty subjects were selected and patch test tape containing 0.03 mL of sample was applied to the normal skin of the subjects' left and right forearms. Within half an hour after removing the patch, the test was performed six times according to the CTFA guidelines (1981). Six days after the patch was removed, an additional test was performed to observe delayed reactions. The identification criteria are shown in Table 6, and the results are shown in Table 7.

[0121] Table 6

[0122] Table 7

[0123] From the above data results, it can be seen that the composition involved in the present disclosure and the cosmetics containing the same are non-irritating to the skin, have no positive reaction, and are mild and non-irritating.

[0124] The applicant declares that the present disclosure uses the above-mentioned embodiments to illustrate the disclosed acne-removing and anti-inflammatory composition containing sulfated Schizophyllan and its applications, but the present disclosure is not limited to the above-mentioned embodiments, that is, it does not mean that the present disclosure must rely on the above-mentioned embodiments for implementation. Those skilled in the art should understand that any improvements to the present disclosure, equivalent replacements of various raw materials in the disclosed product, addition of auxiliary ingredients, and selection of specific methods, etc., fall within the scope of protection and disclosure of the present disclosure.

[0125] The preferred embodiments of the present disclosure are described in detail above. However, the present disclosure is not limited to the specific details of the above embodiments. Within the technical concept of the present disclosure, various simple modifications can be made to the technical solutions of the present disclosure, and these simple modifications all fall within the scope of protection of the present disclosure.

[0126] It should also be noted that the various specific technical features described in the above specific embodiments can be combined in any appropriate manner without contradiction. In order to avoid unnecessary repetition, the present disclosure will not further describe various possible combinations. Industrial Applicability

[0127] The present invention discloses a multi-effect facial mask for removing acne, reducing inflammation, repairing, stabilizing, soothing and hydrating containing a sulfated schizophyllan composition, prepared by organically compounding sulfated schizophyllan and other active ingredients. The mask utilizes the anticoagulant activity of sulfated schizophyllan and the antibacterial and anti-inflammatory effects of kapok flower extract, combined with other active ingredients for synergistic enhancement, to reduce inflammation and remove acne, improve microcirculation, fade acne marks and spots, promote skin metabolism, hydrate and moisturize, regulate water-oil balance, repair skin damage, and strengthen the skin barrier, thereby achieving the effects of removing acne, reducing inflammation, repairing, stabilizing, soothing and hydrating.

[0128] Furthermore, it is understood that the acne-removing and anti-inflammatory composition containing sulfated Schizophyllan and its applications provided in the embodiments of the present disclosure are reproducible and can be used in a variety of industrial applications. For example, the acne-removing and anti-inflammatory composition containing sulfated Schizophyllan and its applications provided in the embodiments of the present disclosure can be used in the field of cosmetics technology.

Claims

1. An anti-acne and anti-inflammatory composition containing sulfated schizophyllan, characterized in that: The acne-removing and anti-inflammatory composition containing sulfated schizophyllan comprises sulfated schizophyllan, kapok flower extract, aloe vera gel and panthenol.

2. The anti-acne and anti-inflammatory composition containing sulfated Schizophyllan according to claim 1, characterized in that: The acne-removing and anti-inflammatory composition containing sulfated schizophyllan comprises, by weight, 0.1-5 parts of sulfated schizophyllan, 0.1-4 parts of kapok flower extract, 10-20 parts of aloe vera gel, and 10-20 parts of panthenol.

3. Use of the anti-acne and anti-inflammatory composition containing sulfated Schizophyllan according to claim 1 or 2 in the preparation of cosmetics.

4. The use according to claim 3, characterized in that: The cosmetics include lotions, facial masks, essences or essence creams.

5. The cosmetic according to claim 3 or 4, characterized in that: The mass fraction of the acne-removing and anti-inflammatory composition containing sulfated schizophyllan in the cosmetic is 1-5 parts.

6. An anti-acne and anti-inflammatory facial mask containing sulfated schizophyllan, characterized in that: The facial mask comprises a facial mask base and a facial mask essence, wherein the facial mask base comprises non-woven cotton, and the facial mask essence comprises the anti-acne and anti-inflammatory composition containing sulfated schizophyllan according to claim 1 or 2, a moisturizer, a thickener and water.

7. The anti-acne and anti-inflammatory facial mask containing sulfated Schizophyllan according to claim 6, characterized in that: The facial mask essence comprises, by weight, 1-5 parts of the anti-acne and anti-inflammatory composition containing sulfated schizophyllan according to claim 1 or 2, 5-10 parts of a moisturizer, 0.1-0.3 parts of a thickener, and water; Preferably, the moisturizing agent comprises any one or a combination of at least two of glycerol, butylene glycol, dipropylene glycol, sorbitol, trehalose or allantoin; Preferably, the thickening agent comprises carbomer.

8. The anti-acne and anti-inflammatory facial mask containing sulfated Schizophyllan according to claim 6 or 7, characterized in that: The facial mask essence also includes a chelating agent and / or a preservative; Preferably, the chelating agent comprises disodium EDTA; Preferably, the preservative comprises phenoxyethanol-ethylhexylglycerin.

9. The method for preparing the anti-acne and anti-inflammatory facial mask containing sulfated Schizophyllan according to any one of claims 6 to 8, characterized in that: The preparation method of the facial mask comprises mixing a facial mask base with a facial mask essence to obtain; The preparation method of the facial mask base comprises: sterilizing the non-woven cotton to obtain; The preparation method of the facial mask essence comprises: mixing a moisturizer, a thickener and water, and then mixing with the anti-acne and anti-inflammatory composition containing sulfated schizophyllan to obtain the facial mask essence.

10. The method for preparing the anti-acne and anti-inflammatory facial mask containing sulfated Schizophyllan according to claim 9, characterized in that: The mask base and mask essence are mixed for 10-20 hours; Preferably, the temperature at which the humectant, thickener and water are mixed is 90-95°C; Preferably, the temperature of mixing the acne-removing and anti-inflammatory composition containing sulfated schizophyllan is 40-45°C; Preferably, the humectant, thickener and water are mixed together with a chelating agent; Preferably, the anti-acne and anti-inflammatory composition containing sulfated Schizophyllan further comprises mixing with a preservative.

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