Magnetic particle separation device

Abstract

Provided in the present application is a magnetic particle separation device, comprising: a magnet fixing member (2), the magnet fixing member (2) being cylindrical, and the magnet fixing member (2) being provided with a plurality of magnet mounting slots (21); and a plurality of magnets (1), the plurality of magnets (1) being mounted in the plurality of magnet mounting slots (21), and the plurality of magnets (1) being arranged in the circumferential direction (C) of the magnet fixing member (2) to form a magnet ring. The radial inner side of the magnet ring is used for placing a container, and the magnet ring forms, on the radial inner side thereof, a uniformly changing magnetic field that gradually increases in strength from the center to the periphery. The magnet ring comprises radially magnetized magnet groups (11) and circumferentially magnetized magnet groups (12), the magnetization direction of the plurality of magnets (1) of the radially magnetized magnet groups (11) being radial, the magnetization direction of the plurality of magnets (1) of the circumferentially magnetized magnet groups (12) being a tangential direction of the circumferential direction corresponding to the position of said magnets in the magnet ring, and the radially magnetized magnet groups (11) and the circumferentially magnetized magnet groups (12) being alternately arranged.

Description

Magnetic particle separation device Technical Field

[0001] The present application belongs to the field of biophysical therapy diagnosis technology, and in particular relates to a magnetic particle separation device. Background Art

[0002] In the field of biophysical diagnosis, magnetic particle separation devices can be used to separate magnetic particles from other components in a sample.

[0003] Chinese patent CN101208153B discloses a device and method for separating magnetic particles, which forms a non-uniform magnetic field through a magnet. However, it has the following disadvantages.

[0004] (1) The structure of the magnet arrangement is complex, resulting in high processing and assembly costs.

[0005] (2) If shielding measures are not taken, there is a risk of magnetic leakage. There is still a magnetic field outside the casing, which has an adverse effect on other devices such as mobile phones and watches.

[0006] (3) The magnetic field change curve is gentle, and there is a large area in the center where the magnetic field is too small, which is not conducive to the aggregation of magnetic particles.

[0007] (4) The upward protruding handle can easily break the glass container.

[0008] (5) The magnetic field strength at different locations in the circumferential direction of the parts with the same radial position in the working area is different, which affects the separation effect.

[0009] Summary of the Invention

[0010] The present application aims to provide a magnetic particle separation device to solve at least one of the above-mentioned disadvantages.

[0011] The embodiments of the present application provide a magnetic particle separation device, comprising:

[0012] a magnet fixing member, the magnet fixing member being cylindrical and provided with a plurality of magnet mounting grooves; and

[0013] A plurality of magnets are mounted in the plurality of magnet mounting slots. The plurality of magnets are arranged along the circumference of the magnet fixing member to form a magnet ring. The radial inner side of the magnet ring is used to place a container. The magnet ring forms a uniformly changing magnetic field on its radial inner side that gradually increases from the center to the periphery.

[0014] The magnet ring includes a radially magnetized magnet group and a circumferentially magnetized magnet group. The magnetization direction of the multiple magnets in the radially magnetized magnet group is radial, and the magnetization direction of the multiple magnets in the circumferentially magnetized magnet group is a tangential direction of the circumference corresponding to the position of the magnet in the magnet ring. The radially magnetized magnet group and the circumferentially magnetized magnet group are arranged alternately.

[0015] In at least one possible embodiment, the magnet mounting groove forms an opening at the inner periphery of the magnet fixing member, and at the inner periphery of the magnet ring, the plurality of magnets are closely attached to each other without any gaps.

[0016] In at least one possible embodiment, the number of magnetic pole pairs of the magnet ring is 4.

[0017] Each of the radially magnetized magnet groups includes a same number of magnets, and each of the circumferentially magnetized magnet groups includes a same number of magnets.

[0018] The radially magnetized magnet group and the circumferentially magnetized magnet group may have the same or different numbers of magnets.

[0019] In at least one possible embodiment, the radially magnetized magnet group includes a first radially magnetized magnet group, a second radially magnetized magnet group, a third radially magnetized magnet group, and a fourth radially magnetized magnet group.

[0020] The circumferentially magnetized magnet group includes a first circumferentially magnetized magnet group, a second circumferentially magnetized magnet group, a third circumferentially magnetized magnet group and a fourth circumferentially magnetized magnet group.

[0021] In a clockwise direction, the first radial magnetization magnet group, the first circumferential magnetization magnet group, the second radial magnetization magnet group, the second circumferential magnetization magnet group, the third radial magnetization magnet group, the third circumferential magnetization magnet group, the fourth radial magnetization magnet group, and the fourth circumferential magnetization magnet group are arranged in sequence to form a magnet ring.

[0022] The internal magnetic flux lines of the first radial magnetization magnet group and the third radial magnetization magnet group point radially inward, and the internal magnetic flux lines of the second radial magnetization magnet group and the fourth radial magnetization magnet group point radially outward.

[0023] The internal magnetic flux lines of the first circumferentially magnetized magnet group and the fourth circumferentially magnetized magnet group point to the first radially magnetized magnet group, and the internal magnetic flux lines of the second circumferentially magnetized magnet group and the third circumferentially magnetized magnet group point to the third radially magnetized magnet group.

[0024] In at least one possible implementation, in each of the radially magnetized magnet groups, the radial dimensions of the magnets located at the edge and adjacent to the circumferentially magnetized magnet group are smaller than the radial dimensions of the remaining magnets.

[0025] In at least one possible embodiment, the magnet ring is provided with only one circle, and the cross section of the magnet is rectangular, sector-shaped or trapezoidal.

[0026] The width of the magnet along the radial direction is greater than the thickness of the magnet along the circumferential direction.

[0027] In at least one possible embodiment, the magnetic particle separation device further includes a shielding cover, which is sleeved on the outside of the magnet ring.

[0028] In at least one possible embodiment, the magnetic particle separation device further includes a sleeve, which is arranged radially inward of the magnet fixing member, and the magnet abuts against the outer circumferential surface of the sleeve to radially position the magnet in the magnet mounting groove.

[0029] In at least one possible embodiment, the magnetic particle separation device further includes a light source, and the light source is disposed on the inner periphery of the sleeve.

[0030] In at least one possible embodiment, an upper cover is connected above the magnet fixing member, and the upper cover is provided with a handle, which extends radially outward from an outer periphery of the upper cover.

[0031] In at least one possible embodiment, each of the radially magnetized magnet groups and each of the circumferentially magnetized magnet groups includes a plurality of magnets, and radial dimensions of at least some of the magnets in the radially magnetized magnet groups are smaller than radial dimensions of the magnets in the circumferentially magnetized magnet groups.

[0032] In at least one possible implementation, the radial dimensions of the magnets located at the edge of each radially magnetized magnet group and adjacent to the circumferentially magnetized magnet group are smaller than the radial dimensions of the magnets in the circumferentially magnetized magnet group.

[0033] In at least one possible implementation, the radially inner ends of the magnets located at the edge of each radially magnetized magnet group and adjacent to the circumferentially magnetized magnet group are located radially outward of the radially inner ends of the remaining magnets.

[0034] In at least one possible implementation, the radial size of the magnets in each radially magnetized magnet group that are located in the middle and not adjacent to the circumferentially magnetized magnet group is smaller than the radial size of the magnets in the circumferentially magnetized magnet group.

[0035] In at least one possible embodiment, the radially outer end of the magnet located in the middle position and not adjacent to the circumferentially magnetized magnet group in each group of the radially magnetized magnets is located radially inward of the radially outer ends of the remaining magnets.

[0036] In at least one possible embodiment, the magnets of the radially magnetized magnet group have the same size, the magnets of the circumferentially magnetized magnet group have the same size, and the radial size of each magnet of the circumferentially magnetized magnet group is larger than the radial size of each magnet of the radially magnetized magnet group.

[0037] In at least one possible embodiment, the magnetic particle separation device also includes a sleeve, which is located radially inside the magnet, and the peripheral wall of the magnet fixing member is provided with a plurality of threaded holes passing through the peripheral wall, and the threaded holes are aligned with the bottom of the magnet mounting groove. The fastener is screwed into the threaded hole to squeeze the magnet radially inward, so that the radial inner side of the magnet abuts against the outer peripheral surface of the sleeve, so that the magnet is radially positioned in the magnet mounting groove.

[0038] By adopting the above technical solution, the magnetic particle separation device of the present application can achieve at least one of the following beneficial effects.

[0039] (1) By alternating radially magnetized magnet groups and circumferentially magnetized magnet groups to form a strong uniformly changing magnetic field, the magnetic particles in the magnetic field can be quickly aggregated.

[0040] (2) The shielding cover can prevent magnetic field leakage, so that the operator and the equipment he carries with him are not affected by the magnetic field.

[0041] (3) Sufficient magnetic field strength can be obtained by a circle of magnets, making it easy to set up the magnetic field of the magnetic particle separation device, using fewer magnets and lowering the cost.

[0042] (4) The working area can be illuminated to facilitate observation of liquid samples in the container.

[0043] (5) The radial magnetization magnet group and the circumferential magnetization magnet group are simply arranged and easily assembled.

[0044] (6) The radial extension of the handle does not affect the taking and placing of the container.

[0045] (7) The magnetic field strength at the same radial position in the working area is consistent at all locations in the circumferential direction, which results in a better separation effect of the magnetic particles. BRIEF DESCRIPTION OF THE DRAWINGS

[0046] FIG1 shows a schematic structural diagram of a magnetic particle separation device according to a first embodiment of the present application.

[0047] FIG2 shows a cross-sectional view of a magnetic particle separation device according to a first embodiment of the present application.

[0048] FIG3 shows a schematic structural diagram of a magnetic particle separation device (the upper cover is not shown) according to the first embodiment of the present application.

[0049] FIG4 shows a schematic diagram of the internal structure of the magnetic particle separation device according to the first embodiment of the present application.

[0050] FIG5 shows a schematic structural diagram of a magnet fixing member of a magnetic particle separation device according to the first embodiment of the present application.

[0051] FIG6 shows a schematic structural diagram of a magnet ring of a magnetic particle separation device according to the first embodiment of the present application.

[0052] FIG7 shows a schematic structural diagram of a magnet ring of a magnetic particle separation device according to another embodiment of the present application.

[0053] FIG8 shows a curve of magnetic field variation along the X-axis in the working area of ​​the magnetic particle separation device according to the first embodiment of the present application.

[0054] FIG9 shows a curve of magnetic field variation along the Y-axis in the working area of ​​the magnetic particle separation device according to the first embodiment of the present application.

[0055] FIG10 shows a curve of magnetic field variation in the working area of ​​the magnetic particle separation device according to the first embodiment of the present application along a direction with an angle of 45 degrees with both the X-axis and the Y-axis.

[0056] FIG11 shows a schematic structural diagram of a magnet fixing member of a magnetic particle separation device according to a second embodiment of the present application.

[0057] FIG12 shows a schematic structural diagram of a magnet ring of a magnetic particle separation device according to a second embodiment of the present application.

[0058] FIG13 shows a curve of magnetic field variation along the X-axis or Y-axis in the working area of ​​the magnetic particle separation device according to the second embodiment of the present application.

[0059] FIG14 shows a curve of magnetic field variation in the working area of ​​the magnetic particle separation device according to the second embodiment of the present application along a direction with an angle of 45 degrees with both the X-axis and the Y-axis.

[0060] Description of Reference Numerals

[0061] 1 magnet

[0062] 11 radial magnetization magnet group 111 first radial magnetization magnet group 112 second radial magnetization magnet group 113 third radial magnetization magnet group 114 fourth radial magnetization magnet group

[0063] 12 Circumferentially magnetized magnet group 121 First circumferentially magnetized magnet group 122 Second circumferentially magnetized magnet group 123 Third circumferentially magnetized magnet group 124 Fourth circumferentially magnetized magnet group

[0064] 2 Magnet fixing part 21 Magnet mounting slot 22 Wire slot 23 Threaded hole

[0065] 3 Shielding cover 31 Shielding cover peripheral wall 32 Shielding cover top wall

[0066] 4 end cover 41 upper end cover 42 lower end cover

[0067] 5 sleeves

[0068] 6 housing 61 housing peripheral wall 62 housing bottom wall

[0069] 7 Upper cover 71 Handle 711 Groove 72 Switch mounting hole

[0070] 8 base 81 battery compartment

[0071] A axial direction C circumferential direction DETAILED DESCRIPTION

[0072] In order to more clearly illustrate the above-mentioned purposes, features and advantages of the present application, this section describes in detail the specific embodiments of the present application in conjunction with the accompanying drawings. In addition to the various embodiments described in this section, the present application can also be implemented in other different ways. Without violating the spirit of the present application, those skilled in the art can make corresponding improvements, deformations and substitutions. Therefore, the present application is not limited to the specific embodiments disclosed in this section. The scope of protection of this application shall be based on the claims.

[0073] (First embodiment)

[0074] As shown in FIG. 1 to FIG. 10 , the first embodiment of the present application proposes a magnetic particle separation device, which includes a plurality of magnets 1 , a magnet fixing member 2 , a shielding cover 3 , an end cover 4 , a sleeve 5 , a housing 6 and an upper cover 7 .

[0075] As shown in Figures 2 to 5, the magnet holder 2 can be cylindrical and provided with a magnet mounting groove 21. The magnet mounting groove 21 can be provided on the inner periphery of the magnet holder 2, and the magnet mounting groove 21 forms an opening on the inner periphery of the magnet holder 2. A plurality of magnet mounting grooves 21 can be provided along the circumferential direction C of the magnet holder 2.

[0076] A wire groove 22 may be provided on the outer periphery of the magnet holder 2 . The wire groove 22 may extend along the axial direction A of the magnet holder 2 . The wire groove 22 is used to accommodate cables.

[0077] Multiple magnets 1 can be embedded in the magnet mounting slots 21 and arranged along the circumferential direction C of the magnet holder 2 to form a magnet ring. A uniformly varying magnetic field can be formed radially inwardly of the magnet ring. The multiple magnets 1 are arranged in a Halbach array, forming a uniformly varying magnetic field radially inwardly of the magnet ring that gradually increases from the center toward the periphery.

[0078] The one-way arrows in FIG6 and FIG7 indicate the direction of the magnetic flux lines inside the magnet 1 (the magnetization direction of the magnet), and the magnetic flux lines point from the S pole to the N pole inside the magnet.

[0079] As shown in Figures 6 and 7, the number of magnetic pole pairs P of the magnet ring can be an integer greater than or equal to 2. In this embodiment, the number of magnetic pole pairs P of the magnet ring can be 4, and the magnet ring has a total of 8 groups of magnets 1. The magnetization directions of the multiple magnets 1 in the same group are substantially the same.

[0080] Optionally, in other possible implementations, the number P of magnetic pole pairs of the magnet ring may also be 8.

[0081] The magnet ring includes a radially magnetized magnet group 11 and a circumferentially magnetized magnet group 12. The magnets of the radially magnetized magnet group 11 can be magnetized in the radial direction of the magnet holder 2, and the magnets of the circumferentially magnetized magnet group 12 can be magnetized in the circumferential direction C of the magnet holder 2. The radially magnetized magnet group 11 and the circumferentially magnetized magnet group 12 are alternately arranged to form a strong uniformly varying magnetic field.

[0082] The magnetization directions of the multiple magnets in the radially magnetized magnet group 11 are substantially the same, but not completely the same. The magnetization direction of each magnet 1 in the radially magnetized magnet group 11 is radial. The magnetization directions of the multiple magnets in the circumferentially magnetized magnet group 12 are substantially the same, but not completely the same. The magnetization direction of each magnet 1 in the circumferentially magnetized magnet group 12 is the circumferential direction (or the tangential direction) of the position of the magnet in the magnet ring.

[0083] As shown in FIG. 6 , the radially magnetized magnet group 11 includes a first radially magnetized magnet group 111 , a second radially magnetized magnet group 112 , a third radially magnetized magnet group 113 and a fourth radially magnetized magnet group 114 .

[0084] The circumferentially magnetized magnet group 12 includes a first circumferentially magnetized magnet group 121 , a second circumferentially magnetized magnet group 122 , a third circumferentially magnetized magnet group 123 and a fourth circumferentially magnetized magnet group 124 .

[0085] In the clockwise direction, the first radial magnetization magnet group 111, the first circumferential magnetization magnet group 121, the second radial magnetization magnet group 112, the second circumferential magnetization magnet group 122, the third radial magnetization magnet group 113, the third circumferential magnetization magnet group 123, the fourth radial magnetization magnet group 114 and the fourth circumferential magnetization magnet group 124 are arranged in sequence to form a magnet ring.

[0086] In this embodiment, the internal magnetic flux lines of the first radial magnetization magnet group 111 and the third radial magnetization magnet group 113 point radially inward, while the internal magnetic flux lines of the second radial magnetization magnet group 112 and the fourth radial magnetization magnet group 114 point radially outward. The internal magnetic flux lines of the first circumferential magnetization magnet group 121 and the fourth circumferential magnetization magnet group 124 point toward the first radial magnetization magnet group 111, while the internal magnetic flux lines of the second circumferential magnetization magnet group 122 and the third circumferential magnetization magnet group 123 point toward the third radial magnetization magnet group 113.

[0087] Each radial magnetization magnet group 11 and each circumferential magnetization magnet group 12 includes multiple magnets. These multiple magnets can ensure that the magnetization direction of each radial magnetization magnet group 11 is radially aligned as much as possible. The multiple magnets can also ensure that the overall magnetization direction of the circumferential magnetization magnet group 12 is as close to an arc as possible rather than a straight line. The number of magnets in each radial magnetization magnet group 11 and the number of magnets in each circumferential magnetization magnet group 12 can be the same. For example, each radial magnetization magnet group 11 and each circumferential magnetization magnet group 12 can have six magnets. That is, the magnetic particle separation device can have eight groups, each group having six magnets 1, for a total of 48 magnets 1.

[0088] The radial width of the magnet 1 can be greater than its thickness along the circumferential direction C. For example, the width of the magnet 1 can be greater than or equal to 1.5 times the thickness and less than 5 times the thickness. The greater the radial width of the magnet 1, the higher the magnetic field strength generated. The smaller the thickness of the magnet 1 along the circumferential direction C, the more uniform the magnetic field generated along the circumferential direction C. The ratio of the magnet's width to thickness can be adjusted according to specific design requirements.

[0089] The magnet ring formed by the above arrangement of magnets only needs one ring to obtain sufficient magnetic field strength, so that the magnetic field of the magnetic particle separation device is easy to set, the number of magnets used is small, and the cost is low.

[0090] In other possible embodiments, the number of magnets in the radially magnetized magnet group 11 and the circumferentially magnetized magnet group 12 may be different. For example, each radially magnetized magnet group 11 may include 5 magnets, and each circumferentially magnetized magnet group 12 may include 4 magnets. In this case, the magnetic particle separation device may have 36 magnets 1. Of course, each radially magnetized magnet group 11 may also include 4 magnets, and each circumferentially magnetized magnet group 12 may include 5 magnets.

[0091] Optionally, the radial dimensions of the magnets located at the edge of each radially magnetized magnet group 11 and adjacent to the circumferentially magnetized magnet group 12 can be smaller than the radial dimensions of the remaining magnets 1, so that the magnetic field strength at the same radial position in the working area can be approximately the same at all locations in the circumferential direction. It will be understood that the radial width or thickness along the circumferential direction C of the magnets at other locations can also be adjusted according to specific needs, and magnets at different locations can have different sizes or shapes.

[0092] It can be understood that the dimensions of the magnet mounting slots 21 accommodating the magnets 1 with smaller radial dimensions may be correspondingly smaller in depth than the remaining magnet mounting slots 21 .

[0093] On the inner circumference of the magnet ring, the multiple magnets 1 forming the magnet ring can be closely attached to each other without any gaps. This helps ensure that the magnetic field strength at the same radial position in the working area is approximately the same at all locations along the circumference. It should be understood that this is merely an example embodiment and is not intended to be limiting. Even if gaps exist between the multiple magnets on the inner circumference of the magnet ring, a strong, uniformly varying magnetic field can still be generated.

[0094] As shown in Figure 6 , the cross section of the magnet may be rectangular, and the manufacturing cost of a magnet with a rectangular cross section is lower. In other possible implementations, as shown in Figure 7 , the cross section of the magnet may also be fan-shaped or trapezoidal.

[0095] As shown in Figures 2 to 4, end caps 4 are mounted on both axial ends of the magnet holder 2. End caps 4 include an upper end cap 41 and a lower end cap 42. The upper end cap 41 can be connected to the upper end of the magnet holder 2 by fasteners such as bolts, and the lower end cap 42 can be connected to the lower end of the magnet holder 2 by fasteners such as bolts. The lower end cap 42 can be used to place a container. The container is located radially inward of the sleeve 5. The space for placing the container can be called a working area, and the container can hold the sample to be separated.

[0096] The sleeve 5 can be cylindrical and can be disposed in the hollow area of ​​the magnet holder 2. The axial ends of the sleeve 5 can be connected to the end caps 4, the upper end of the sleeve 5 can be connected to the upper end cap 41, and the lower end of the sleeve 5 can be connected to the lower end cap 42. The sleeve 5 is located radially inward of the magnet 1, and the radial inner portion of the magnet 1 can abut against the outer circumferential surface of the sleeve 5, so that the magnet 1 is radially positioned in the magnet mounting groove 21 and does not fall out.

[0097] The upper cover 7 can be connected to the upper end cover 41, and the outer periphery of the upper cover 7 can be provided with a handle 71 protruding radially outward, and the lower part of the handle 71 can be provided with a groove 711, or the handle 71 can be provided with a hollow, so that the fingers can be inserted into the groove 711 or the hollow to hook the handle 71, thereby facilitating the movement of the magnetic particle separation device.

[0098] A light source such as an LED light strip may be provided on the inner periphery of the sleeve 5. Optionally, the light source is located at the lower end of the sleeve 5, and the working area can be illuminated by the light source, making it easier to observe the liquid sample (such as blood) in the container.

[0099] As shown in Figures 2 and 3, the shielding cover 3 is mounted on the outside of the magnet ring. The shielding cover 3 may include a shielding cover peripheral wall 31 and a shielding cover top wall 32. The shielding cover peripheral wall 31 may be mounted on the outer periphery of the magnet fixing member 2, and the shielding cover top wall 32 may be connected to the upper end cover 41. The shielding cover top wall 32 is located above the magnet ring.

[0100] The shielding cover 3 can be made of a ferromagnetic material such as iron. The shielding cover 3 can prevent the magnetic field from escaping from the upper side and the surrounding side of the magnetic particle separation device and affecting the space outside the working area of ​​the magnetic particle separation device. For example, the shielding cover can prevent the operator and his / her watch, mobile phone, etc. from being affected by the magnetic field of the magnetic particle separation device.

[0101] It is understood that in other possible embodiments, the shielding cover 3 may further include a shielding cover bottom wall (not shown in the figure), which may be connected to the lower end cover to prevent the magnetic field from escaping downward from the working area.

[0102] The base 8 can be connected to the lower end cover 42 and can be provided with a battery compartment 81 and a control board. The battery compartment 81 can accommodate batteries, which can power the light source. The battery compartment 81 can be provided with a pole piece, and the positive and negative poles of the battery installed in the battery compartment 81 can contact the pole piece. The light source and the pole piece can be electrically connected to the control board. The control board can be connected to the switch button via a cable. The upper cover 7 can be provided with a switch mounting hole 72, and the switch button is installed in the switch mounting hole 72. Operating the switch button can turn the light source on or off.

[0103] As shown in FIG. 2 , the housing 6 may include a housing peripheral wall 61 and a housing bottom wall 62 . The housing peripheral wall 61 may be disposed on the outer periphery of the shielding cover peripheral wall 31 , and the housing bottom wall 62 may be disposed below the base 8 .

[0104] Referring to Figures 8 to 10 , at magnetic field strengths less than 0.1 Tesla, for example, the rate at which magnetic particles aggregate in the magnetic field decreases significantly. Therefore, the region of lower magnetic field strength should not be too large. In the embodiment of the present application, the diameter range corresponding to a 0.1 Tesla magnetic field strength is 18 mm, resulting in a steeper magnetic field growth curve and a smaller region of lower magnetic field strength.

[0105] In FIG8 to FIG10, the abscissa represents the radius from the center of the working area (in millimeters), and the ordinate represents the magnetic field intensity (in millitesla).

[0106] As shown in FIG8 , in the X-axis direction, the magnetic field strength increases gradually from the center of the magnet holder toward the outside, and there is no sudden change.

[0107] As shown in FIG9 , in the Y-axis direction, the magnetic field strength increases gradually from the center of the magnet fixture outward without sudden changes.

[0108] As shown in FIG10 , in a direction where the angles with the X-axis and the Y-axis are both 45 degrees, the magnetic field strength increases gradually from the center of the magnet fixture outward without sudden changes.

[0109] It can be understood that at a position far from the center of the working area and close to the sleeve 5, the magnitude of the magnetic field will not affect the magnetic particles, because this position corresponds to the gap between the container and the sleeve 5 and there are no magnetic particles.

[0110] The magnetic particle separation device of the present application can achieve the following beneficial effects.

[0111] (1) By alternately arranging the radially magnetized magnet group 11 and the circumferentially magnetized magnet group 12, a strong uniformly changing magnetic field is formed, which can quickly aggregate the magnetic particles in the magnetic field.

[0112] (2) The shielding cover can prevent magnetic field leakage, so that the operator and the equipment he carries with him are not affected by the magnetic field.

[0113] (3) Sufficient magnetic field strength can be obtained by a circle of magnets, making it easy to set up the magnetic field of the magnetic particle separation device, using fewer magnets and lowering the cost.

[0114] (4) The working area can be illuminated to facilitate observation of liquid samples in the container.

[0115] (5) The radial magnetization magnet group 11 and the circumferential magnetization magnet group 12 are arranged simply and are easy to assemble.

[0116] (6) The radial extension of the handle does not affect the taking and placing of the container.

[0117] (Second embodiment)

[0118] The magnetic particle separation device of the second embodiment has an overall structure similar to that of the first embodiment, with the primary differences being the magnet 1 and the magnet holder 2. These differences are discussed below. The same reference numerals are used to designate the same or similar components of the magnetic particle separation device of the second embodiment and the first embodiment.

[0119] As shown in Figures 1 to 3 and Figures 11 to 14, the second embodiment of the present application proposes a magnetic particle separation device, which includes multiple magnets 1, a magnet fixing part 2, a shielding cover 3, an end cover 4, a sleeve 5, a shell 6, an upper cover 7 and a base 8.

[0120] As shown in FIG11 , the peripheral wall of the magnet holder 2 can be provided with a plurality of threaded holes 23. The threaded holes 23 extend through the peripheral wall of the sleeve 5 and can be aligned with the bottom (i.e., the radially outer portion) of the magnet mounting slot 21. For the same magnet mounting slot 21, multiple threaded holes 23 can be provided along the axial direction of the sleeve 5. By screwing a fastener, such as a stud, into the threaded hole 23, the magnet 1 is pressed radially inward. This allows the radially inner portion of the magnet 1 to abut against the outer circumferential surface of the sleeve 5, thereby radially positioning the magnet 1 in the magnet mounting slot 21 and preventing it from falling out.

[0121] The magnet 1 includes a radially magnetized magnet group 11 and a circumferentially magnetized magnet group 12 . The radially magnetized magnet group 11 and the circumferentially magnetized magnet group 12 are alternately arranged to form a strong uniformly varying magnetic field.

[0122] As shown in FIG12 , the radial dimensions of at least some of the magnets 1 of the radially magnetized magnet group 11 may be smaller than the radial dimensions of the magnets 1 of the circumferentially magnetized magnet group 12 , so that the magnetic field strengths at various locations in the circumferential direction at the same radial position in the working area may be substantially the same.

[0123] In the illustrated example, the magnets of the circumferentially magnetized magnet group 12 can be of the same size, and the magnets of the radially magnetized magnet group 11 can be of the same size. The radial dimensions of the magnets of the radially magnetized magnet group 11 are smaller than the radial dimensions of the magnets of the circumferentially magnetized magnet group 12. In each radially magnetized magnet group 11, the magnets 1 located at the edge, adjacent to the circumferentially magnetized magnet group 12, are arranged radially outward relative to the magnets 1 located in the middle, not adjacent to the circumferentially magnetized magnet group 12. This reduces the number of magnets of different specifications (two in this example), thus reducing the number of components, simplifying the assembly process, and lowering costs.

[0124] The number of magnets in each radial magnetization magnet group 11 and the number of magnets in each circumferential magnetization magnet group 12 can be the same. For example, the number of magnets in each radial magnetization magnet group 11 and each circumferential magnetization magnet group 12 is 5. That is, the magnetic particle separation device can have 8 groups of 5 magnets 1 each, for a total of 40 magnets 1.

[0125] The magnet ring formed by the above arrangement of magnets only needs one ring to obtain sufficient magnetic field strength, so that the magnetic field of the magnetic particle separation device is easy to set, the number of magnets used is small, and the cost is low.

[0126] In other possible implementations, the magnets of the circumferentially magnetized magnet group 12 may have different sizes, and / or the magnets of the radially magnetized magnet group 11 may have different sizes. In particular, the magnets of the radially magnetized magnet group 11 may have different sizes.

[0127] In FIG. 13 and FIG. 14 , the abscissa represents the coordinate position of the working area (in millimeters), and the ordinate represents the magnetic field intensity (in Teslas).

[0128] As shown in FIG13 , in the X-axis direction and the Y-axis direction, from one end to the other end of the working area, the magnetic field strength gradually weakens and then gradually increases without sudden changes, and the magnetic field strength at the center of the working area is close to 0.

[0129] As shown in FIG14 , in a direction where the angles with the X-axis and the Y-axis are both 45 degrees, from one end of the working area to the other end, the magnetic field strength gradually weakens and then gradually increases without sudden changes. The magnetic field strength at the center of the working area is close to 0.

[0130] 13 and 14 , the curves of the magnetic field strength changing with position along the X-axis direction, along the Y-axis direction, and along the direction with an angle of 45 degrees with the X-axis and the Y-axis are basically the same. It can be considered that the magnetic field strength at various locations in the circumferential direction of the parts with the same radial position in the working area is consistent, resulting in a better separation effect of the magnetic particles.

[0131] Specifically, the radial dimensions of the magnets 1 located at the edge of each radially magnetized magnet group 11 and adjacent to the circumferentially magnetized magnet group 12 can be smaller than the radial dimensions of the magnets 1 in the circumferentially magnetized magnet group 12. It is understood that the magnets 1 with smaller radial dimensions located at the edge of each radially magnetized magnet group 11 can be a single magnet at the very edge, or multiple magnets located near the edge. For example, they can be two or four magnets located at the two end edges of the five magnets, or two or four magnets located at the two end edges of the six magnets.

[0132] The radially inner end of the magnet 1 located at the edge of each radially magnetized magnet group 11 and adjacent to the circumferentially magnetized magnet group 12 may be located radially outward of the radially inner end of the remaining magnets 1 .

[0133] It is understood that the magnets 1 located at the edge of each radially magnetized magnet group 11 and adjacent to the circumferentially magnetized magnet group 12 can be provided with spacers on the radially inner side, and the magnets 1 can be abutted against the outer wall of the sleeve 5 through the spacers. The spacers can be made of aluminum or an aluminum alloy.

[0134] The radial dimensions of the magnet 1 located in the middle of each radially magnetized magnet group 11 and not adjacent to the circumferentially magnetized magnet group 12 can be smaller than the radial dimensions of the magnets 1 in the circumferentially magnetized magnet group 12. The multiple magnets 1 in a radially magnetized magnet group 11 can be symmetrical along the centerline of the radially magnetized magnet group 11. It is understood that the magnet 1 with smaller radial dimensions located in the middle of each radially magnetized magnet group 11 can be the magnet located in the middle or multiple magnets located relatively in the middle. For example, it can be one magnet or three magnets located in the middle of the five magnets, or it can be two magnets or four magnets located in the middle of the six magnets.

[0135] The radially outer end of the magnet 1 located in the middle position of each radially magnetized magnet group 11 and not adjacent to the circumferentially magnetized magnet group 12 may be located radially inward of the radially outer ends of the remaining magnets 1 .

[0136] It is understood that the radially smaller magnets 1 located in the middle of each radially magnetized magnet group 11 and not adjacent to the circumferentially magnetized magnet group 12 can be squeezed using longer fasteners such as studs. Alternatively, the magnet mounting slots 21 that accommodate these radially smaller magnets 1 can be smaller in depth than the remaining magnet mounting slots 21.

[0137] As shown in Figure 12, the cross section of the magnet can be rectangular, and the manufacturing cost of a magnet with a rectangular cross section is lower. In other possible implementations, the cross section of the magnet can also be fan-shaped or trapezoidal.

[0138] The magnetic particle separation device of the present application can ensure that the magnetic field strength at each location in the circumferential direction of the parts with the same radial position in the working area is consistent, thereby achieving a better separation effect of the magnetic particles.

[0139] It should be understood that at least some aspects or features of the above-mentioned embodiments, examples or examples may be appropriately combined.

[0140] It is understood that in this application, when the number of parts or components is not specifically limited, the number may be one or more, and the term "plurality" herein refers to two or more. Where the number of parts or components is shown in the drawings and / or described in the specification as a specific number, such as two, three, or four, the specific number is generally illustrative and not restrictive, and may be understood as a plurality, i.e., two or more. However, this does not mean that this application excludes the case of one.

[0141] In this application, unless otherwise clearly stated or limited, terms such as "install", "assemble", "connect", "connect", "couple", "link", "abut", "connect", "interconnect", "communicate", "conduct", "fix", "fasten", etc. should be understood in a broad sense, for example, they can be direct or indirect. For example, with respect to connection, it can be a fixed connection, a detachable connection, or an integrated connection; it can be a mechanical connection or an electrical connection; it can be a direct connection or an indirect connection through an intermediate medium, it can be the internal connection of two elements or the interaction relationship between two elements, unless otherwise clearly stated or limited. For example, with respect to connectivity / conduction, it can be direct connectivity / conduction or indirect connectivity / conduction through an intermediate medium. For ordinary technicians in this field, the specific meanings of the above terms in this application can be understood according to the specific circumstances.

[0142] In the present application, unless otherwise clearly stated or limited, a component provided on / installed on / located on / accommodated on / placed in, within, inside, etc. another component may be any of the following two situations: a part or most of the one component is located in the other component; and the one component is completely accommodated in the other component.

[0143] While the present application has been described in detail using the above-described embodiments, it will be apparent to those skilled in the art that the present application is not limited to the embodiments described in this specification. The present application can be modified and implemented as modified embodiments without departing from the subject matter and scope of the present application as defined by the claims. Therefore, the descriptions in this specification are for illustrative purposes only and do not have any limiting meaning with respect to the present application.

Claims

1. A magnetic particle separation device, characterized in that, Comprising: A magnet fixing member (2), the magnet fixing member (2) being cylindrical, and the magnet fixing member (2) being provided with a plurality of magnet mounting grooves (21); And A plurality of magnets (1), the plurality of magnets (1) being mounted in the plurality of magnet mounting grooves (21), the plurality of magnets (1) being arranged along the circumference (C) of the magnet fixing member (2) to form a magnet ring, the radially inner side of the magnet ring being for placing a container, and the magnet ring forming a uniformly varying magnetic field that gradually increases from the center to the surroundings on its radially inner side, The magnet ring includes a radially magnetized magnet group (11) and a circumferentially magnetized magnet group (12), the magnetization directions of the plurality of magnets (1) in the radially magnetized magnet group (11) being radial, and the magnetization directions of the plurality of magnets (1) in the circumferentially magnetized magnet group (12) being the tangential direction of the circumference corresponding to the position of the magnet in the magnet ring, and the radially magnetized magnet group (11) and the circumferentially magnetized magnet group (12) being alternately arranged.

2. The magnetic particle separation device according to claim 1, wherein The magnet mounting grooves (21) form openings at the inner peripheral portion of the magnet fixing member (2), and at the inner peripheral portion of the magnet ring, the plurality of magnets (1) are in close contact with each other without gaps.

3. The magnetic particle separation device according to claim 1, characterized in that, The number of pole pairs of the magnet ring is 4, Each of the radially magnetized magnet groups (11) includes the same number of a plurality of magnets, and each of the circumferentially magnetized magnet groups (12) includes the same number of a plurality of magnets, The number of magnets in the radially magnetized magnet group (11) and the circumferentially magnetized magnet group (12) may be the same or different.

4. The magnetic particle separation device according to claim 1, characterized in that, The radially magnetized magnet group (11) includes a first radially magnetized magnet group (111), a second radially magnetized magnet group (112), a third radially magnetized magnet group (113), and a fourth radially magnetized magnet group (114), The circumferentially magnetized magnet group (12) includes a first circumferentially magnetized magnet group (121), a second circumferentially magnetized magnet group (122), a third circumferentially magnetized magnet group (123), and a fourth circumferentially magnetized magnet group (124), In the clockwise direction, the first radially magnetized magnet group (111), the first circumferentially magnetized magnet group (121), the second radially magnetized magnet group (112), the second circumferentially magnetized magnet group (122), the third radially magnetized magnet group (113), the third circumferentially magnetized magnet group (123), the fourth radially magnetized magnet group (114), and the fourth circumferentially magnetized magnet group (124) are arranged in sequence to form a magnet ring, The internal magnetic induction lines of the first radially magnetized magnet group (111) and the third radially magnetized magnet group (113) point radially inward, and the internal magnetic induction lines of the second radially magnetized magnet group (112) and the fourth radially magnetized magnet group (114) point radially outward, The internal magnetic induction lines of the first circumferentially magnetized magnet group (121) and the fourth circumferentially magnetized magnet group (124) point to the first radially magnetized magnet group (111), and the internal magnetic induction lines of the second circumferentially magnetized magnet group (122) and the third circumferentially magnetized magnet group (123) point to the third radially magnetized magnet group (113).

5. The magnetic particle separation device according to claim 1, wherein In each group of the radially magnetized magnet groups (11), the radial dimension of the magnet (1) located at the edge position and adjacent to the circumferentially magnetized magnet group (12) is smaller than the radial dimensions of the remaining magnets (1).

6. The magnetic particle separation device according to claim 1, characterized in that There is only one ring of magnets, and the cross-section of the magnet (1) is rectangular, fan-shaped or trapezoidal. The width of the magnet (1) along the radial direction is greater than the thickness along the circumferential direction.

7. The magnetic particle separation device according to claim 1, characterized in that The magnetic particle separation device further includes a shielding cover (3), and the shielding cover (3) is sleeved outside the magnet ring.

8. The magnetic particle separation device according to claim 1, wherein The magnetic particle separation device further includes a sleeve (5), and the sleeve (5) is arranged on the radial inner side of the magnet fixing member (2). The magnet (1) abuts against the outer peripheral surface of the sleeve (5) to radially position the magnet (1) in the magnet mounting groove (21).

9. The magnetic particle separation device according to claim 8, characterized in that, The magnetic particle separation device further includes a light source, and the light source is arranged on the inner peripheral part of the sleeve (5).

10. The magnetic particle separation device according to claim 1, characterized in that, An upper cover (7) is connected above the magnet fixing member (2), and the upper cover (7) is provided with a handle (71). The handle (71) extends radially outward from the outer peripheral part of the upper cover (7).

11. The magnetic particle separation device according to claim 1, wherein, Each group of the radially magnetized magnet groups (11) and each group of the circumferentially magnetized magnet groups (12) each include a plurality of the magnets (1). The radial dimension of at least some of the magnets (1) in the radially magnetized magnet group (11) is smaller than the radial dimension of the magnets (1) in the circumferentially magnetized magnet group (12).

12. The magnetic particle separation device according to claim 11, characterized in that, In each group of the radially magnetized magnet groups (11), the radial dimension of the magnet (1) located at the edge position and adjacent to the circumferentially magnetized magnet group (12) is smaller than the radial dimension of the magnets (1) in the circumferentially magnetized magnet group (12).

13. The magnetic particle separation device according to claim 12, wherein In each group of the radially magnetized magnet groups (11), the radial inner end of the magnet (1) located at the edge position and adjacent to the circumferentially magnetized magnet group (12) is located radially outside the radial inner end of the remaining magnets (1).

14. The magnetic particle separation device according to claim 11, wherein In each group of the radially magnetized magnet groups (11), the radial dimension of the magnet (1) located at the middle position and not adjacent to the circumferentially magnetized magnet group (12) is smaller than the radial dimension of the magnets (1) in the circumferentially magnetized magnet group (12).

15. The magnetic particle separation device according to claim 14, characterized in that, In each group of the radially magnetized magnet groups (11), the radial outer end of the magnet (1) located at the middle position and not adjacent to the circumferentially magnetized magnet group (12) is located radially inside the radial outer end of the remaining magnets (1).

16. The magnetic particle separation device according to claim 11, characterized in that, The dimensions of the magnets in the radially magnetized magnet group (11) are the same, the dimensions of the magnets in the circumferentially magnetized magnet group (12) are the same, and the radial dimension of the magnets in the circumferentially magnetized magnet group (12) is greater than the radial dimension of the magnets in the radially magnetized magnet group (11).

17. The magnetic particle separation device according to claim 11, wherein, The magnetic particle separation device further includes a sleeve (5), the sleeve (5) is located on the radial inner side of the magnet (1), a plurality of threaded holes (22) penetrating through the peripheral wall are provided on the peripheral wall of the magnet fixing member (2), the threaded holes (22) are aligned with the bottom of the magnet mounting groove (21), and a fastener is screwed into the threaded holes (22) to squeeze the magnet (1) towards the radial inner side, so that the radial inner part of the magnet (1) abuts against the outer peripheral surface of the sleeve (5), and the magnet (1) is radially positioned in the magnet mounting groove (21).

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