Biological specimen storage system

Abstract

A biological specimen storage system, comprising an operation cabin (1) and a storage cabin (2). The operation cabin is arranged above the storage cabin and is used for retrieving or storing a specimen tube within the storage cabin. The operation cabin is provided with a retrieval member (11), the retrieval member is provided with a retrieval hook docking piece (111), and the retrieval hook docking piece can be docked with a cryopreservation tube and / or a cryopreservation tube tank and / or a jar lid of a transport jar and / or a storage cabin cover of the storage cabin and retrieve same. In the present storage system, the retrieval member is used for transferring a straw tank, thus retrieving cryopreservation tubes, and is also capable of opening the storage cabin cover of the storage cabin.

Description

A biological sample storage system Technical Field

[0001] The present invention relates to the technical field of sample storage, and in particular to a biological sample storage system. Background Art

[0002] In the field of sample storage, cryogenic storage is used to store biological samples such as blood samples, vaccines, bacterial and viral strains, etc. at low temperatures, so that the samples can be kept active at low temperatures.

[0003] In current automated sample storage equipment, functions such as opening, grabbing, and removing lids are usually set up separately, resulting in a large number of mechanisms set up in the operation chamber, a cumbersome work process, and difficulty in timely monitoring and automated operation. Therefore, a new storage system is urgently needed to simplify the mechanisms in the operation chamber while realizing multi-functional applications and ensuring stability and safety.

[0004] Summary of the Invention

[0005] The purpose of this section is to summarize some aspects of the embodiments of the present invention and briefly introduce some preferred embodiments. Some simplifications or omissions may be made in this section and the abstract and title of this application to avoid obscuring the purpose of this section, the abstract and the title of the invention, and such simplifications or omissions should not be used to limit the scope of the present invention.

[0006] In view of the above problems or problems existing in the prior art, the present invention is proposed.

[0007] Therefore, the purpose of the present invention is to provide a biological sample storage system, which can grab multiple cryopreservation tubes, cryopreservation tube barrels and storage tank covers on the side of the storage cabin through an extraction component set in the operation cabin, and can limit the position during the grabbing process to prevent them from moving to ensure stability and safety, and can realize the storage and retrieval of cryopreservation tubes. The cabin cover can be slid by the cover moving mechanism, so that the extraction component can perform the next operation, and the transfer tank can be docked with the operation cabin. The upper cover of the transfer tank can be opened by the cover opening mechanism, and the extraction component can extract the cryopreservation tubes in the middle tank and place them in the storage cabin.

[0008] To solve the above technical problems, the present invention provides the following technical solutions: a biological sample storage system, comprising an operation cabin and a storage cabin; the operation cabin is arranged above the storage cabin and extracts or stores sample tubes in the storage cabin;

[0009] An extraction component is provided in the operation cabin, and the extraction component is provided with an extraction hook docking piece, which can dock with the freezing tube and / or freezing tube barrel and / or transfer tank cover and / or storage cabin cover respectively and extract them.

[0010] As a preferred solution of the biological sample storage system of the present invention, the extraction hook docking piece includes a positive snap-fit ​​piece, and the freezing tube and / or freezing tube barrel and / or transfer tank cover and / or storage compartment cover are all provided with a negative snap-fit ​​piece, the positive snap-fit ​​piece can be snapped onto the negative snap-fit ​​piece, and the negative snap-fit ​​piece limits the positive snap-fit ​​piece in the vertical direction.

[0011] As a preferred embodiment of the biological sample storage system of the present invention, the extraction component includes an extraction X-axis moving component and an extraction Z-axis moving component, the extraction hook docking member is arranged on the extraction Z-axis moving component, and the extraction Z-axis moving component can drive the extraction hook docking member to move up and down or extend and retract in the Z-axis direction; the extraction Z-axis moving component is arranged on the extraction X-axis moving component, and the extraction X-axis moving component can drive the extraction Z-axis moving component to move in the X-axis direction.

[0012] As a preferred embodiment of the biological sample storage system of the present invention, the extraction hook docking member further includes an extraction rod, an extraction sleeve, and a positive snap-fit ​​member; the extraction sleeve is arranged on the periphery of the extraction rod, and the extraction rod can move up and down relative to the extraction sleeve; the extraction rod and the extraction sleeve can move up and down in the Z-axis direction; and the positive snap-fit ​​member is arranged at the lower end of the extraction rod.

[0013] As a preferred solution of the biological sample storage system of the present invention, the extraction Z-axis moving assembly includes a Z-axis support frame, a drive chain, and a Z-axis drive cylinder; the lower end of the Z-axis support frame is slidably arranged on the X-axis moving assembly; a Z-axis vertical rail is arranged on the side of the Z-axis support frame close to the extraction sleeve, and the Z-axis drive cylinder drives the extraction sleeve to move up and down on the Z-axis vertical rail; the drive chain drives the extraction rod to move up and down.

[0014] As a preferred embodiment of the biological sample storage system of the present invention, the extraction rod has a semi-arc-shaped end with a central cavity extending downward from the lower end thereof, the lower end surface of the semi-arc-shaped end being connected to a snap-on plate; one side end of the snap-on plate is recessed inwardly to form a positive snap-on groove; the semi-arc-shaped end and the snap-on plate form a positive snap-on component.

[0015] As a preferred solution of the biological sample storage system of the present invention, the positive snap-in groove includes an inner groove section and an outer groove section, the outer side of the inner groove section is connected to the outer groove section, the outer groove section gradually shrinks from the outside to the inside, and the inner groove section is U-shaped.

[0016] As a preferred solution of the biological sample storage system of the present invention, a fixing sleeve is provided extending outward from the lower end of the extraction sleeve, and a clamping plate is provided below the fixing sleeve.

[0017] As a preferred solution of the biological sample storage system of the present invention, a limiting opening is provided on the side wall of the fixing sleeve, and the limiting opening can be engaged with a limiting block provided on the cover of the transfer tank and / or the storage compartment cover of the storage compartment.

[0018] As a preferred solution of the biological sample storage system of the present invention, an extraction rod limiting block is provided at the upper end of the extraction rod to limit the extraction height of the extraction rod in the Z-axis direction.

[0019] As a preferred solution of the biological sample storage system of the present invention, a stop block is provided at the lower end of the extraction sleeve, the stop block is located between the extraction sleeve and the extraction rod, and limits the extension length of the extraction rod.

[0020] As a preferred solution of the biological sample storage system of the present invention, the operating cabin also includes a cover-sliding mechanism, which is located above the storage cabin hatch; the cover-sliding mechanism includes a cover-sliding plate seat and a Y-direction slide rail; the cover-sliding plate seat is slidably arranged on the Y-direction slide rail.

[0021] As a preferred solution of the biological sample storage system of the present invention, an extraction handle is provided on the upper end surface of the storage compartment cover of the storage compartment, and the extraction handle can be engaged with the positive engaging member.

[0022] As a preferred embodiment of the biological sample storage system of the present invention, an extraction handle and an extraction clamping block are provided on the upper end surface of the storage compartment cover of the storage compartment, and the extraction handle and the extraction clamping block form a female clamping part of the storage compartment cover; the extraction handle is clamped with the male clamping groove of the clamping plate; and the extraction clamping block is clamped with the limiting opening of the fixing sleeve.

[0023] As a preferred solution of the biological sample storage system of the present invention, the extraction handle is cylindrical, and the free end of its upper end forms a truncated cone for engaging with the clip; the extraction clip block is arranged beside the extraction handle and is in a trapezoidal block shape, engaging with the positive clip groove of the clip plate.

[0024] As a preferred solution of the biological sample storage system of the present invention, a cover opening mechanism is further provided in the storage compartment, and the cover opening mechanism can open the cover of the transfer tank.

[0025] As a preferred embodiment of the biological sample storage system of the present invention, the storage compartment further comprises a central rotating shaft and a honeycomb plate; the honeycomb plate is rotatably disposed on the central rotating shaft; a plurality of cryotubes and / or cryotube barrels containing cryotubes can be inserted into the honeycomb plate;

[0026] The upper ends of the cryopreservation tube and the cryopreservation tube barrel are both provided with an extraction handle, which is cylindrical, and the free end of the upper end forms a frustum for fitting and clamping.

[0027] As a preferred solution of the biological sample storage system of the present invention, the upper end of the cryotube barrel is trumpet-shaped.

[0028] As a preferred embodiment of the biological sample storage system of the present invention, the storage chamber further includes a support tube, the lower portion of the central rotating shaft is connected to the support tube, a rotating shaft drive is provided above the central rotating shaft, the rotating shaft drive can drive the central rotating shaft to rotate, and liquid nitrogen is provided in the storage chamber.

[0029] As a preferred solution of the biological sample storage system of the present invention, the operation cabin further includes a code scanner, which is arranged on one side of the extraction component.

[0030] As a preferred solution of the biological sample storage system of the present invention, it further includes a lifting mechanism, which is arranged on one side of the storage cabin and located at the lower end of the operation cabin, and can lift the transfer tank into the operation cabin.

[0031] As a preferred solution of the biological sample storage system of the present invention, the lifting mechanism includes a connecting frame, a lifting frame, and a supporting guide rail. The connecting frame is connected to the outer wall of the storage compartment. The supporting guide rail is set at the lower end of the connecting frame. The lifting frame is vertically slidably connected to the supporting guide rail, and the supporting guide rail can drive the lifting frame to rise and fall.

[0032] As a preferred solution of the biological sample storage system of the present invention, a liquid nitrogen valve assembly is provided on the side of the storage compartment; and a support and a wheel assembly are provided at the bottom end of the storage compartment.

[0033] As a preferred solution of the biological sample storage system of the present invention, the fixing sleeve is vertically slidably connected to the extraction rod.

[0034] The beneficial effects of the present invention are as follows: 1. The straw barrel can be transferred by the extraction member to realize the storage and retrieval of frozen storage tubes, and the storage hatch cover of the storage compartment can be moved to open, thus realizing multiple uses of one mechanism; 2. The limiting block on the storage hatch cover of the storage compartment can be limited by the limiting opening on the fixing sleeve to prevent the storage hatch cover from rotating during the transfer process; 3. The straw barrel can be limited by the fixing sleeve to prevent the straw barrel from shaking during the transfer process; 4. The extraction rod limiting block and the stop block are provided on the extraction rod to limit the upper and lower extension lengths of the extraction rod; 5. By setting the barcode scanner in the lifting path, the identification of the cryopreservation tube barrel can be realized during the lifting process, which is convenient and quick; 6. By setting the cover-moving mechanism, the storage hatch cover can be translated on the Y-axis, and the storage hatch cover can be moved in conjunction with the extraction component; 7. By setting the jacking mechanism, the transfer tank can be quickly docked with the operation cabin, and the extraction component can be used to place the cryopreservation tubes in the middle tank in the storage cabin, which greatly improves work efficiency; 8. The present invention simplifies many structures and work processes in the operation cabin and realizes fully automated operation, which not only ensures stability and safety, but also improves overall efficiency. BRIEF DESCRIPTION OF THE DRAWINGS

[0035] In order to more clearly illustrate the technical solutions of the embodiments of the present invention, the following briefly introduces the drawings required for describing the embodiments. Obviously, the drawings described below are only some embodiments of the present invention. Those skilled in the art can also derive other drawings based on these drawings without inventive effort. Among them:

[0036] FIG1 is an overall schematic diagram of a biological sample storage system.

[0037] FIG2 is a schematic diagram of the operation cabin of the biological sample storage system.

[0038] FIG3 is a schematic diagram of an extraction component of a biological sample storage system.

[0039] FIG. 4 is an enlarged view of F1 of the biological sample storage system in FIG. 3 .

[0040] FIG5 is a partial cross-sectional enlarged view of the drive chain of the biological sample storage system.

[0041] FIG6 is a partial cross-sectional enlarged view of the positive connector of the biological sample storage system.

[0042] FIG7 is a schematic diagram of a cover removal mechanism of a biological sample storage system.

[0043] FIG8 is a schematic diagram of a straw barrel of a biological sample storage system.

[0044] FIG9 is a schematic diagram of the cover opening mechanism of the biological sample storage system.

[0045] FIG10 is a schematic diagram of a storage compartment of a biological sample storage system.

[0046] FIG11 is a schematic diagram of the interior of a storage compartment of a biological sample storage system.

[0047] FIG12 is a schematic diagram of the lifting mechanism of the biological sample storage system.

[0048] Reference numerals:

[0049] Operation cabin, 1; Storage cabin, 2; Extraction component, 11; Extraction hook docking member, 111; Male snap-fitting member, 1111; Female snap-fitting member, 19; Extraction X-axis moving assembly, 112; Extraction Z-axis moving assembly, 113; Extraction rod, 1113; Extraction sleeve, 1114; Z-axis support frame, 1131; Drive chain, 1132; Z-axis drive cylinder, 1133; Z-axis vertical rail, 1134; Semi-arc end, 11113; Snap-fitting plate, 11111; Male snap-fitting groove, 11112; Fixed sleeve, 1 115; limit opening, 1116; cover shifting mechanism, 12; cover shifting plate seat; 121; Y-axis slide rail, 122; extraction handle, 11121; extraction clamping block, 11122; cover opening mechanism, 22; center shaft, 23; honeycomb plate, 24; support cylinder, 25; shaft drive, 26; barcode scanner, 18; lifting mechanism, 3; connecting frame, 31; lifting frame, 32; support rail, 33; liquid nitrogen valve assembly, 29; straw barrel, S1; straw barrel sleeve, S2; transfer tank, S6; storage hatch, S7; DETAILED DESCRIPTION

[0050] In order to make the above-mentioned objects, features and advantages of the present invention more obvious and easy to understand, the specific embodiments of the present invention are described in detail below with reference to the accompanying drawings.

[0051] In the following description, many specific details are set forth to facilitate a full understanding of the present invention. However, the present invention may also be implemented in other ways different from those described herein. Those skilled in the art may make similar generalizations without violating the connotation of the present invention. Therefore, the present invention is not limited to the specific embodiments disclosed below.

[0052] Secondly, the term "one embodiment" or "embodiment" herein refers to a specific feature, structure, or characteristic that may be included in at least one implementation of the present invention. The phrase "in one embodiment" appearing in various places throughout this specification does not necessarily refer to the same embodiment, nor does it refer to a separate or selective embodiment that is mutually exclusive of other embodiments.

[0053] Example 1

[0054] 1 to 8 , a first embodiment of the present invention is shown, which provides a biological sample storage system comprising an operation cabin 1 and a storage cabin 2. The operation cabin 1 is disposed above the storage cabin 2 and extracts or stores sample tubes in the storage cabin 2.

[0055] An extraction component 11 is provided in the operation cabin 1, and the extraction component 11 is provided with an extraction hook docking piece 111. The extraction hook docking piece 111 can dock with the freezing tube and / or freezing tube barrel and / or transfer tank S6 tank cover and / or storage cabin cover S7 of the storage cabin and extract them.

[0056] Preferably, the cryopreservation tubes are stored and frozen through the storage cabin, and an operation cabin 1 is provided above the storage cabin 2, and an extraction component 11 is provided in the operation cabin 1. The extraction component 11 includes an extraction hook docking member 111, and the cryopreservation tubes, cryopreservation tube barrels, transfer tank S6, and storage cabin cover S7 can be extracted through the extraction hook docking member 111. In the existing low-temperature storage system, when it is necessary to store or advance or transport cells or other substances stored in the cryopreservation tubes, the cryopreservation tubes will be placed in the transfer tank S6, or the cryopreservation tubes will be placed in the cryopreservation tube barrels and then placed in the transfer tank S6, and the transfer tank S6 will be used for transportation or access; the transfer tank S6 is docked to the storage device, and the transfer tank S6 and the storage device are opened to allow the cryopreserved tubes therein to reach their destination. In this process, the cryopreserved tubes or cryopreserved tube barrels must first be placed in or taken out of the transfer tank S6 in advance, and the storage hatch S7 of the storage device must be opened to transfer the cryopreserved tubes to their destinations. To achieve full automation in this process, a gripper for opening the lid of the transfer tank S6 and a gripper for opening the storage hatch S7 of the storage cabin must be provided. An extraction arm for extracting and storing the cryopreserved tubes or an extraction arm for extracting the cryopreserved tube barrels must also be provided. Different motion regulation systems that match these different target settings must also be provided, resulting in a complex structure and high cost. In the present invention, an extraction component is provided in the operating cabin, and the extraction component is provided with an extraction hook docking piece. The extraction hook docking piece can dock with the cryopreserved tubes and / or cryopreserved tube barrels and / or the transfer tank S6 lid and / or the storage hatch S7 of the storage cabin and extract them. The extraction component is used to achieve multifunctional extraction and storage. The operating cabin 1 has a relatively simple structure, greatly reduced cost, and more stable operation. The extraction hook docking piece 111 can achieve multiple functions while ensuring stability and safety.

[0057] In summary, the present invention can dock with and extract the freezing tube and / or the freezing tube barrel and / or the transfer tank S6 cover and / or the storage compartment cover S7 of the storage compartment through the extraction hook docking piece 111, thereby simplifying the internal structure and work flow of the operation cabin 1 and realizing fully automated operation, which not only ensures the stability and safety during the transportation process, but also improves the overall efficiency.

[0058] Example 2

[0059] 1 to 12 , a second embodiment of the present invention is shown. Based on the previous embodiment, the biological sample storage system includes an operation cabin 1 and a storage cabin 2. The operation cabin 1 is disposed above the storage cabin 2 and extracts or stores sample tubes in the storage cabin 2.

[0060] An extraction component 11 is provided in the operation cabin 1, and the extraction component 11 is provided with an extraction hook docking piece 111. The extraction hook docking piece 111 can dock with the freezing tube and / or freezing tube barrel and / or transfer tank S6 tank cover and / or storage cabin cover S7 of the storage cabin and extract them.

[0061] Cryopreservation tubes can be stored and frozen through the storage cabin 2. An operating cabin 1 is set above the storage cabin 2, and an extraction component 11 is set in the operating cabin 1. The extraction component 11 includes an extraction hook docking piece 111. The extraction hook docking piece 111 can be used to extract cryopreservation tubes, cryopreservation tube barrels, and storage cabin covers S7, which simplifies the internal structure and work flow of the operating cabin 1. The extraction hook docking piece 111 can realize multiple functions while ensuring stability and safety.

[0062] In a preferred further implementation of this embodiment, the extraction hook docking piece includes a male snap-fitting piece, and the freezing tube and / or freezing tube sleeve barrel and / or transfer tank S6 can lid and / or storage compartment cover S7 are all provided with a female snap-fitting piece, and the male snap-fitting piece can be snapped onto the female snap-fitting piece, and the female snap-fitting piece limits the positive snap-fitting piece in the vertical direction. The male snap-fitting piece provided on the extraction hook docking piece limits the female snap-fitting piece in the vertical direction, and can be set to be unrestricted in some other direction. When it needs to be docked and snapped, it is snapped from the unrestricted direction to limit its vertical direction, thereby realizing extraction or storage or other operations in the vertical direction; this arrangement realizes the multifunctional extraction or storage of the freezing tube and / or freezing tube sleeve barrel and / or transfer tank S6 can lid and / or storage compartment cover S7 by the extraction hook docking piece at a low cost.

[0063] A preferred further implementation of this embodiment is that the extraction component 11 includes an extraction X-axis moving component 112 and an extraction Z-axis moving component 113. The extraction hook docking member 111 is arranged on the extraction Z-axis moving component 113, and the extraction Z-axis moving component 113 can drive the extraction hook docking member 111 to move up and down or extend and retract in the Z-axis direction; the extraction Z-axis moving component 113 is arranged on the extraction X-axis moving component 112, and the extraction X-axis moving component 112 can drive the extraction Z-axis moving component 113 to move in the X-axis direction.

[0064] The extraction X-axis moving assembly 112 is arranged in the operation cabin 1, and the extraction Z-axis moving assembly 113 can slide along the X-axis moving assembly 112 in the X-direction; the extraction Z-axis moving assembly 113 can drive the extraction hook docking member 111 to move up and down or extend and retract in the Z-axis direction. As shown in Figure 2, this arrangement not only realizes the up and down movement of the extraction component 11 in the Z-axis direction, but also the range of movement in the X-axis direction can set the X-axis movement path according to needs, which provides the maximum movement space and optimized path for the extraction component 11 to dock with the cryopreservation tube and / or cryopreservation tube barrel and / or transfer tank S6 tank cover and / or storage compartment storage compartment storage compartment cover S7.

[0065] In a preferred further implementation embodiment of this embodiment, the extraction hook docking member 111 also includes an extraction rod 1113, an extraction sleeve 1114 and a positive snap-in member 1111; the extraction sleeve 1114 is sleeved on the outer periphery of the extraction rod 1113, and the extraction rod 1113 can move up and down relative to the extraction sleeve 1114; the extraction rod 1113 and the extraction sleeve 1114 can move up and down in the Z-axis direction; the positive snap-in member 1111 is arranged at the lower end of the extraction rod 1113.

[0066] When it is necessary to extract the target, taking the process starting from extracting the cryopreservation tube in the transfer tank S6 as an example, the transfer tank S6 is moved into the operation cabin and is in the corresponding position of the extraction component. The extraction rod 1113 and the extraction sleeve 1114 can be lowered at the same time. When the lower end of the extraction sleeve 1114 drops to the tank mouth of the transfer tank S6, it stops descending, and the extraction rod 1113 continues to descend and extends into the transfer tank S6 to extract the cryopreservation tube or cryopreservation tube sleeve barrel inside it. The extraction here is the clamping of the negative clamping part and the positive clamping part, and the upper limit extraction in the vertical direction; after the cryopreservation tube or cryopreservation tube sleeve barrel is extracted, The extraction rod 1113 rises back upward, and the extraction sleeve 1114 waits for the extraction rod 1113 at the position where it just stopped, until the extraction rod extracts the cryopreservation tube or the cryopreservation tube sleeve barrel into the extraction sleeve 1114. After being at least partially surrounded or wrapped by the extraction sleeve 1114, the extraction rod 1113 and the extraction sleeve 1114 move upward at the same time until they reach the target height; the advantage of this setting is that the extraction sleeve 1114 protects the extracted cryopreservation tube and provides a relatively stable mobile environment space. Because of low-temperature storage, the cryopreservation tube will be affected by the temperature environment at the moment it is taken out of the transfer tank S6.

[0067] After reaching the target height, it is driven on the X axis to move to the storage opening of the storage compartment by the X axis moving assembly 112. In this process, the extraction sleeve 1114 is also carried out to the protection of the stability of the extracted target always.

[0068] A preferred further implementation method of this embodiment is that the extraction Z-axis moving component 113 includes a Z-axis support frame 1131, a driving chain 1132, and a Z-axis driving cylinder 1133; the lower end of the Z-axis support frame 1131 is slidably set on the X-axis moving component 112; a Z-axis vertical rail 1134 is set on the side of the Z-axis support frame 1131 close to the extraction sleeve 1114, and the Z-axis driving cylinder 1133 drives the extraction sleeve 1114 to move up and down on the Z-axis vertical rail 1134; the driving chain 1132 drives the extraction rod 1113 to move up and down.

[0069] The driving chain 1132 drives the extraction rod 1113 to move downward until the male engaging member is engaged with the female engaging member, and the male engaging member is limited in the vertical direction;

[0070] It should be noted here that this technical solution utilizes the flexibility of the drive chain 1132 to cooperate with the up and down movement of the extraction sleeve 1114, which not only realizes the up and down movement of the extraction rod 1113 itself, but also realizes a more stable cooperation with the extraction sleeve 1114.

[0071] A preferred further implementation manner of this embodiment is that the extraction Z-axis moving assembly includes a Z-axis support frame 1131 and an X-axis moving assembly 112 which are slidably connected in the X-axis direction. The side of the Z-axis support frame 1131 is connected to the Z-axis vertical rail 1134. A Z-axis driving cylinder 1133 is provided on the Z-axis vertical rail 1134. The Z-axis driving cylinder 1133 can drive the extraction sleeve 1114 to perform independent lifting. The extraction sleeve 1114 is sleeved on the outside of the extraction rod 1113. The extraction sleeve 1114 can provide a guide for the extraction rod 1113, which can ensure that the extraction rod 1113 is always lifted and lowered along the extraction sleeve 1114, and ensure that the Z-axis direction of the extraction rod 1113 will not deviate during the grasping process.

[0072] Preferably, the driving chain 1132 includes a driving motor, a driving gear, and a chain. The upper end of the Z-axis support frame 1131 is provided with a driving motor, which is connected to the driving gear. The driving gear drives the chain to rotate. One end of the chain is connected to the upper end of the extraction rod 1113, and the extraction rod 1113 can be driven to rise and fall through the chain; the lower end of the extraction rod 1113 is fixedly connected to the male clip 1111, that is, the driving chain 1132 can drive the extraction rod 1113 and the male clip 1111 to rise and fall.

[0073] Preferably, the driving chain 1132 can adopt a driving lifting device of the existing technology, as long as it can drive the extraction rod 1113 to move up and down.

[0074] Furthermore, a semi-arc-shaped end 11113 with a central cavity extends downward from the lower end of the extraction rod 1113, and the lower end surface of the semi-arc-shaped end is connected to the clamping plate 11111; a male clamping groove 11112 is recessed inwardly at one side end of the clamping plate 11111; the semi-arc-shaped end 11113 and the clamping plate 11111 form a male clamping member 1111. The semi-arc-shaped end 11113 can better meet the requirements of docking with cryopreservation tubes or cryopreservation tube barrels (because the upper ends of cryopreservation tubes or cryopreservation tube barrels are relatively small and cylindrical, the semi-arc-shaped end 11113 can better dock), and can also stably extract the tank cover of the transfer tank S6 and the storage compartment cover S7 of the storage compartment. Preferably, the clamping plate 11111 can engage the extraction handle 11121 on the cryopreservation tube sleeve and the storage compartment cover S7.

[0075] Furthermore, the male snap-fitting groove 11112 includes an inner groove section and an outer groove section. The outer side of the inner groove section is connected to the outer groove section. The outer groove section gradually shrinks from the outside to the inside, and the inner groove section is U-shaped.

[0076] Preferably, the lower end face of the semi-arc end 11113 is fixedly connected to the snap-in plate 11111, and a positive snap-in groove 11112 is provided on the snap-in plate 11111. The outer groove section of the positive snap-in groove 11112 serves as a guide end, which can enable the extraction handle 11121 to smoothly enter the inner groove section of the positive snap-in groove 11112, and the snap-in plate 11111 can support the extraction handle 11121 during the transfer process.

[0077] Furthermore, the extraction hook docking piece 111 includes a positive snap-fit ​​piece 1111, and the cryopreservation tube and / or cryopreservation tube barrel and / or transfer tank S6 can cover and / or storage compartment cover S7 of the storage compartment 2 are all provided with a negative snap-fit ​​piece 19, and the positive snap-fit ​​piece 1111 can be snapped onto the negative snap-fit ​​piece 19, and the negative snap-fit ​​piece 19 limits the positive snap-fit ​​piece 1111 in the vertical direction.

[0078] Furthermore, a fixing sleeve 1115 is provided outwardly extending from the lower end of the extraction sleeve 1114 , and a clamping plate 11111 is provided below the fixing sleeve 1115 .

[0079] Preferably, the fixing sleeve 1115 can engage the straw barrel S1 during the lifting process to ensure that the straw barrel S1 does not shake, and the clamping plate 11111 can lift the extraction handle 11121 on the straw barrel S1, thereby achieving stable transportation.

[0080] Preferably, the extraction sleeve 1114 is fixedly connected to the fixing sleeve 1115 , that is, the Z-direction driving cylinder 1133 can drive the extraction sleeve 1114 and the fixing sleeve 1115 to move up and down along the Z-direction vertical rail 1134 .

[0081] Furthermore, the fixing sleeve 1115 is vertically slidably connected to the extraction rod 1113 .

[0082] Preferably, the fixing sleeve 1115 and the extracting rod 1113 can be raised and lowered independently.

[0083] Furthermore, a limiting opening 1116 is provided on the side end wall of the fixing sleeve 1115, and the limiting opening 1116 can be engaged with a limiting block provided on the tank cover of the transfer tank S6 and / or the storage compartment cover S7 of the storage compartment.

[0084] Preferably, the limit block provided on the cover of the transfer tank S6 and / or the storage compartment cover S7 of the storage compartment can be an extraction clamping block 11122 or other limit blocks, and the limit opening 1116 can limit the limit block to prevent the cover of the transfer tank S6 or the storage compartment cover S7 from shaking during the transfer process.

[0085] Furthermore, an extraction rod limit block is provided at the upper end of the extraction rod 1113 to limit the extraction height of the extraction rod 1113 in the Z-axis direction.

[0086] Preferably, the upper side of the extraction rod 1113 is connected to a extraction rod limit block, and the extraction rod limit block is located on the inner side of the extraction sleeve 1114, and the extraction rod limit block slides vertically following the extraction rod 1113; a limiting rod (not shown in the figure) is connected to the Z-direction support frame 1131, and the limiting rod is arranged above the extraction rod 1113 and close to the position below the drive motor, which can limit the Z-direction extraction height of the extraction rod 1113.

[0087] Furthermore, a stop block is provided at the lower end of the extraction sleeve 1114 , and the stop block is located between the extraction sleeve 1114 and the extraction rod 1113 , and limits the extension length of the extraction rod 1113 .

[0088] Preferably, the stop block and the extraction rod limit block are on the same vertical line, and the extraction sleeve 1114 will drive the stop block to rise and fall. When the extraction rod 1113 drives the extraction rod limit block to descend to the lowest point of the extraction sleeve 1114, the stop block will prevent the extraction rod limit block from continuing to descend, thereby preventing the extraction rod 1113 from separating from the extraction sleeve 1114, resulting in the inability to limit the extraction when the extracted items are extracted, and avoiding shaking during the transfer movement.

[0089] Furthermore, the operating cabin 1 also includes a cover sliding mechanism 12, which is located above the hatch of the storage cabin 2; the cover sliding mechanism 12 includes a cover sliding plate seat 121 and a Y-direction slide rail 122; the cover sliding plate seat 121 is slidably set on the Y-direction slide rail 122.

[0090] Furthermore, an extraction handle 11121 is provided on the upper end surface of the storage compartment cover S7 of the storage compartment 2, and the extraction handle 11121 can be engaged with the male engaging member 1111.

[0091] Preferably, the extracting component 11 can extract the storage compartment cover S7 of the storage compartment 2 and place it on the sliding cover plate seat 121, and then the sliding cover plate seat 121 drives the storage compartment cover S7 to translate in the Y-axis direction to a position that does not affect the storage operation.

[0092] Furthermore, the upper end surface of the storage compartment cover S7 of the storage compartment 2 is provided with an extraction handle 11121 and an extraction clamping block 11122, and the extraction handle 11121 and the extraction clamping block 11122 form a female clamping part 19 of the storage compartment cover S7; the extraction handle 11121 is clamped with the male clamping groove 11112 of the clamping plate 11111; the extraction clamping block 11122 is clamped with the limiting opening 1116 of the fixing sleeve 1115.

[0093] Preferably, by engaging the extraction handle 11121 with the positive engaging groove 11112 of the engaging plate 11111, the engaging plate 11111 can hook the extraction handle 11121 to limit the vertical movement direction, and the extraction engaging block 11122 can be engaged through the limiting opening 1116 on the fixing sleeve 1115, thereby limiting the left and right shaking of the storage hatch S7 during transportation.

[0094] Furthermore, the extraction handle 11121 is cylindrical, and the free end of its upper end forms a cone for fitting and snapping; the extraction snap-in block 11122 is arranged beside the extraction handle 11121 and is in the shape of a trapezoidal block, which is snapped into the male snap-in groove 11112 of the snap-in plate 11111.

[0095] Preferably, the clamping plate 11111 can hook the truncated cone and thereby lift the storage hatch S7, thereby extracting the clamping block 11122 to engage with the limiting opening 1116 for limiting.

[0096] Preferably, when extracting the storage hatch S7, the clamping plate 11111 can clamp and lift the extraction handle 11121, and at the same time, the limiting opening 1116 on the fixing sleeve 1115 can clamp the extraction clamping block 11122 to ensure that no rotation occurs when the storage hatch S7 is transported.

[0097] Furthermore, a cover opening mechanism 22 is provided in the storage compartment 2, and the cover opening mechanism 22 can open the tank cover of the transfer tank S6.

[0098] Furthermore, the storage compartment 2 further includes a central rotating shaft 23 and a honeycomb plate 24; the honeycomb plate 24 is rotatably disposed on the central rotating shaft 23; a plurality of cryotubes and / or cryotube barrels containing cryotubes can be inserted into the honeycomb plate 24;

[0099] The upper ends of the cryopreservation tube and the cryopreservation tube barrel are both provided with an extraction handle 11121. The extraction handle 11121 is cylindrical, and the free end of the upper end forms a frustum for fitting.

[0100] Furthermore, the upper end of the cryopreservation tube barrel is trumpet-shaped.

[0101] Preferably, the freezing tube sleeve barrel includes a straw barrel S1 and a straw barrel sleeve S2. Cryogenic tubes are stored inside the straw barrel S1. The upper end surface of the straw barrel S1 is provided with an extraction handle 11121. The upper end of the straw barrel sleeve S2 is trumpet-shaped. The straw barrel sleeve S2 is provided on a honeycomb plate 24. A plurality of honeycomb holes are provided on the honeycomb plate 24. The straw barrel sleeve S2 can be placed in the honeycomb holes. Since the upper end of the straw barrel sleeve S2 is trumpet-shaped, the honeycomb plate 24 can support the straw barrel sleeve S2, and the straw barrel S1 can be placed in the straw barrel sleeve S2. Liquid nitrogen is provided in the straw barrel sleeve S2 to buffer the straw barrel S1.

[0102] Furthermore, the storage cabin 2 also includes a support tube 25, the lower part of the central shaft 23 is connected to the support tube 25, and a shaft drive 26 is provided above the central shaft 23. The shaft drive 26 can drive the central shaft 23 to rotate. Liquid nitrogen is provided in the storage cabin 2.

[0103] Preferably, the shaft drive 26 can drive the central shaft 23 to rotate, the central shaft 23 drives the honeycomb panel 24 to rotate, and the support tube 25 can support the honeycomb panel 24.

[0104] Furthermore, the operating cabin 1 also includes a code scanner 18 , which is arranged on one side of the extraction component 11 .

[0105] Preferably, the barcode scanner 18 is arranged near the lower end of the Z-axis support frame 1131 and is located on one side of the extraction hook docking piece 111, so as to facilitate the extraction hook docking piece 111 to scan and identify when extracting the straw bucket S1 or the cryopreservation tube.

[0106] Furthermore, it also includes a lifting mechanism 3, which is arranged on one side of the storage cabin 2 and located at the lower end of the operating cabin 1, and can lift the transfer tank S6 into the operating cabin 1.

[0107] Furthermore, the lifting mechanism 3 includes a connecting frame 31, a lifting frame 32, and a supporting guide rail 33. The connecting frame 31 is connected to the outer wall of the storage compartment 2. The supporting guide rail 33 is set at the lower end of the connecting frame 31. The lifting frame 32 is vertically slidably connected to the supporting guide rail 33, and the supporting guide rail 33 can drive the lifting frame 32 to rise and fall.

[0108] Preferably, a medium-sized tank can be placed on the jacking frame 32, and the jacking frame 32 can be driven to move up and down by a driving device on the support rail 33. The jacking frame 32 is vertically slidably connected to the support rail 33.

[0109] Furthermore, a liquid nitrogen valve assembly 29 is provided on the side of the storage cabin 2; and a support and a wheel assembly are provided at the bottom end of the storage cabin 2.

[0110] Preferably, the liquid nitrogen capacity in the storage chamber 2 can be monitored in real time through the liquid nitrogen valve assembly 29 .

[0111] Preferably, the access channel can be covered by a storage compartment cover S7 of the storage compartment.

[0112] The working principle of this device is as follows: first, the driving device on the support rail 33 can drive the lifting frame 32 to drive the transfer tank S6 to move up and down, dock with the operation cabin 1, and enter the operation cabin 1, then use the cover opening mechanism 22 to open the tank cover of the transfer tank S6, move to the top of the transfer tank S6 through the extraction component 11, and use the extraction hook docking piece 111 to temporarily place the internal straw barrel S1 into the operation cabin 1, and during the extraction process, the straw barrel S1 can be scanned and identified by the barcode scanner 18, then moved to the top of the storage cabin cover S7 of the storage cabin through the extraction component 11, and then The positive engaging piece 1111 on the extraction hook docking piece 111 is engaged with the negative engaging piece 19 on the storage hatch cover S7, thereby lifting the storage hatch cover S7. Then, the cover-moving mechanism 12 slides to the bottom of the positive engaging piece 1111. The extraction component 11 places the storage hatch cover S7 on the cover-moving plate seat 121. Then, it moves along the Y-axis slide rail 122 to move the storage hatch cover S7 to one side. Then, the extraction component 11 lifts the straw barrel S1 temporarily placed in the operation cabin 1, enters the storage cabin 2 through the access channel, and places the straw barrel S1. Place it in the straw barrel sleeve S2 on the honeycomb panel 24 to realize frozen storage of the cryopreservation tube. After the storage is completed, the extraction component 11 withdraws from the storage compartment 2 and is lifted a distance. Then the cover-moving mechanism 12 drives the storage compartment cover S7 to move to the bottom of the extraction component 11. The extraction component 11 grabs the storage compartment cover S7, and then the cover-moving mechanism 12 returns to its initial position. The extraction component 11 places the storage compartment cover S7 in the entry and exit channel, and the cover-opening mechanism 22 puts the cover of the transfer tank S6 back on the transfer tank S6. Then the lifting mechanism 3 drives the transfer tank S6 away from the operating cabin 1 to wait for the next operation.

[0113] It is important to note that the construction and arrangement of the present application shown in a number of different exemplary embodiments are merely illustrative. Although only a few embodiments are described in detail in this disclosure, it should be readily understood by those who refer to this disclosure that many modifications are possible (e.g., the size, scale, structure, shape and proportion of various elements, as well as parameter values ​​(e.g., temperature, pressure, etc.), mounting arrangements, use of materials, color, directional changes, etc.) without departing substantially from the novel teachings and advantages of the subject matter described in this application. For example, an element shown as integrally formed may be composed of multiple parts or elements, the position of the element may be inverted or otherwise changed, and the nature or number or position of the discrete elements may be altered or changed. Therefore, all such modifications are intended to be included within the scope of the present invention. The order or sequence of any process or method steps may be changed or reordered according to alternative embodiments. In the claims, any "means plus function" clause is intended to cover the structure described herein that performs the function, and is not only structurally equivalent but also equivalent structures. Other replacements, modifications, changes, and omissions may be made in the design, operating conditions, and arrangement of the exemplary embodiments without departing from the scope of the present invention. Therefore, the invention is not limited to the specific embodiments, but extends to various modifications that still fall within the scope of the appended claims.

[0114] Additionally, in order to provide a concise description of exemplary embodiments, all features of an actual embodiment (i.e., those features that are not relevant to the best mode presently contemplated for carrying out the invention or those that are not relevant to implementing the invention) may not be described.

[0115] It will be appreciated that in the development of any actual embodiment, as in any engineering or design project, numerous implementation-specific decisions may be made. Such a development effort may be complex and time-consuming, but will, for those of ordinary skill having the benefit of this disclosure, be a routine undertaking of design, fabrication, and production without undue experimentation.

[0116] It should be noted that the above embodiments are only used to illustrate the technical solutions of the present invention and are not intended to limit the present invention. Although the present invention has been described in detail with reference to the preferred embodiments, those skilled in the art should understand that the technical solutions of the present invention may be modified or replaced by equivalents without departing from the spirit and scope of the technical solutions of the present invention, which should all be included in the scope of the claims of the present invention.

Claims

1. A biological sample storage system, characterized in that: It includes an operation cabin and a storage cabin; the operation cabin is arranged above the storage cabin and is used to extract or store the sample tubes in the storage cabin. An extraction component is arranged in the operation cabin. The extraction component is provided with an extraction hook docking component, and the extraction hook docking component can be respectively docked with a cryotube and / or a cryotube sleeve and / or a transfer tank lid and / or a storage cabin lid of the storage cabin and extract them.

2. The biological sample storage system according to claim 1, wherein: The extraction hook docking component includes a male clamping component. Female clamping components are arranged on the cryotube and / or the cryotube sleeve and / or the transfer tank lid and / or the storage cabin lid of the storage cabin. The male clamping component can be clamped on the female clamping component, and the female clamping component limits the male clamping component in the vertical direction.

3. The biological sample storage system according to claim 1 or 2, characterized in that: The extraction component includes an extraction X-axis moving component and an extraction Z-axis moving component. The extraction hook docking component is arranged on the extraction Z-axis moving component, and the extraction Z-axis moving component can drive the extraction hook docking component to move up and down or stretch in the Z-axis direction; the extraction Z-axis moving component is arranged on the extraction X-axis moving component, and the extraction X-axis moving component can drive the extraction Z-axis moving component to move in the X-axis direction.

4. The biological sample storage system according to claim 3, wherein: The extraction hook docking component further includes an extraction rod, an extraction sleeve, and a male clamping component; the extraction sleeve is sleeved around the extraction rod, and the extraction rod can move up and down relative to it in the extraction sleeve; the extraction rod and the extraction sleeve can move up and down in the Z-axis direction; the male clamping component is arranged at the lower end of the extraction rod.

5. The biological sample storage system according to claim 4, wherein: The extraction Z-axis moving component includes a Z-direction support frame, a driving chain, and a Z-direction driving cylinder; the lower end of the Z-direction support frame is slidably arranged on the X-axis moving component; a Z-direction vertical rail is arranged on the side of the Z-direction support frame close to the extraction sleeve, and the Z-direction driving cylinder drives the extraction sleeve to move up and down on the Z-direction vertical rail; the driving chain drives the extraction rod to move up and down.

6. The biological sample storage system according to claim 4, wherein: A semi-circular end with a middle cavity extends downward from the lower end of the extraction rod, and a clamping plate is connected to the lower end surface of the semi-circular end; a male clamping groove is recessed inward at one side end of the clamping plate; the semi-circular end and the clamping plate form a male clamping component.

7. The biological sample storage system according to claim 6, wherein: The male clamping groove includes an inner groove section and an outer groove section. The outer side of the inner groove section is connected to the outer groove section, and the outer groove section gradually narrows from outside to inside. The inner groove section is U-shaped.

8. The biological sample storage system according to any one of claims 4 to 7, characterized in that: A fixed sleeve extends outward from the lower end of the extraction sleeve, and a clamping plate is arranged below the fixed sleeve.

9. The biological sample storage system according to claim 8, wherein: A limiting opening is formed on the side wall of the fixed sleeve. The limiting opening can be engaged with a limiting block arranged on the transfer tank lid and / or the storage cabin lid of the storage cabin.

10. The biological sample storage system according to claim 9, wherein: An extraction rod limiting block is arranged at the upper end of the extraction rod to limit the extraction height of the extraction rod in the Z-axis direction.

11. The biological sample storage system according to claim 9 or 10, characterized in that: A stop block is arranged at the lower end of the extraction sleeve. The stop block is located between the extraction sleeve and the extraction rod and limits the elongation length of the extraction rod.

12. The biological sample storage system according to claim 1, 2, 4, 5, 6, 7, 9 or 10, characterized in that: The operation cabin further includes a cover moving mechanism, and the cover moving mechanism is located above the hatch of the storage cabin; the cover moving mechanism includes a cover moving plate seat and a Y-direction slide rail; the cover moving plate seat is slidably arranged on the Y-direction slide rail.

13. The biological sample storage system according to claim 2, 4, 5, 6 or 7, characterized in that: An extraction handle is provided on the upper end surface of the storage hatch of the storage compartment, and the extraction handle can be engaged with the male engagement member.

14. The biological sample storage system according to claim 9 or 10, characterized in that: An extraction handle and an extraction engaging block are provided on the upper end surface of the storage hatch of the storage compartment. The extraction handle and the extraction engaging block form the female engagement member of the storage hatch. The extraction handle is engaged with the male engagement groove of the engagement plate. The extraction engaging block is engaged with the limit opening of the fixed sleeve.

15. The biological sample storage system according to claim 14, wherein: The extraction handle is cylindrical, and a frustum is formed at the free end of its upper end for mating engagement. The extraction engaging block is provided beside the extraction handle and is in the shape of a trapezoid-like block, and is engaged with the male engagement groove of the engagement plate.

16. The biological sample storage system according to claim 1, wherein: An opening mechanism is further provided in the storage compartment, and the opening mechanism can open the lid of the transfer tank.

17. The biological sample storage system according to claim 1, 2, 4, 5, 6, 7, 9 or 10, characterized in that: The storage compartment further includes a central rotating shaft and a honeycomb plate. The honeycomb plate is rotatably arranged on the central rotating shaft. A plurality of cryotubes and / or cryotube sleeves containing cryotubes can be inserted into the honeycomb plate. Extraction handles are provided at the upper ends of both the cryotube and the cryotube sleeve. The extraction handle is cylindrical, and a frustum is formed at the free end of its upper end for mating engagement.

18. The biological sample storage system according to claim 17, wherein: The upper end of the cryotube sleeve is trumpet-shaped.

19. The biological sample storage system according to claim 17, wherein: A support cylinder is further included in the storage compartment. The lower part of the central rotating shaft is connected to the support cylinder, and a rotating shaft drive is provided above the central rotating shaft. The rotating shaft drive can drive the central rotating shaft to rotate. Liquid nitrogen is provided in the storage compartment.

20. The biological sample storage system according to claim 1, 2, 4, 5, 6, 7, 9, 10, 16 or 18, characterized in that: The operation compartment further includes a barcode scanner, and the barcode scanner is provided on one side of the extraction member.

21. The biological sample storage system according to claim 1, 2, 4, 5, 6, 7, 9, 10, 16 or 18, characterized in that: A lifting mechanism is further included. The lifting mechanism is provided on one side of the storage compartment and is located at the lower end of the operation compartment, and can lift the transfer tank into the operation compartment.

22. The biological sample storage system according to claim 21, wherein: The lifting mechanism includes a connecting frame, a lifting frame, and a support guide rail. The connecting frame is connected to the outer wall of the storage compartment. A support guide rail is provided at the lower end of the connecting frame. The lifting frame is vertically slidably connected to the support guide rail, and the support guide rail can drive the lifting frame to move up and down.

23. The biological sample storage system according to claim 20, wherein: A liquid nitrogen valve assembly is provided on the side of the storage compartment. A support and a wheel set are provided at the bottom end of the storage compartment.

24. The biological sample storage system according to claim 8, characterized in that: The fixed sleeve and the extraction rod can be vertically slidably connected.

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