Guide wire and connection structure

Abstract

Provided is a guide wire having tip end flexibility. A guide wire 1 according to this disclosure comprises: a core shaft 9; a coil body 3 covering a tip end part of the core shaft 9; a tip end connection part 2 connecting the tip end of the coil body 3 and the tip end of the core shaft 9; and a base end connection part 5 connecting the base end of the coil body 3 and the core shaft 9, and including an adhesive made of a resin material.

Description

Guidewire and connecting structure

[0001] FIELD OF THE DISCLOSURE The present disclosure relates to medical guidewires and connecting structures.

[0002] Patent document 1 describes a guide wire comprising a core wire, a metal coil attached to the outer periphery of the tip of the core wire, a brazed portion attached between the tip of the metal coil and the tip of the core wire, a brazed portion attached between the middle part of the metal coil and the core wire, and a brazed portion attached between the base end of the metal coil and the core wire.

[0003] JP 2011-143077 A

[0004] In the guidewire described in Patent Document 1, the brazed portion is made of a metal material, and therefore there is a problem in that the rigidity of the guidewire increases, particularly at the brazed portion.

[0005] Because a guidewire is inserted along meandering blood vessels inside a patient's body, there is a risk that the guidewire may become stuck inside the patient's body during a procedure, and the metal coil (hereinafter referred to as the "coil body") may become detached from the core wire (hereinafter referred to as the "core shaft") due to excessive force applied by the operator. For this reason, it is desirable to take safety measures in advance in anticipation of such a situation.

[0006] The present disclosure has been made in view of the above-mentioned problems, and has an object to provide a guidewire having tip flexibility.

[0007] In order to solve the above-mentioned problems, the guide wire of the first aspect comprises a core shaft, a coil body covering a distal end of the core shaft, a distal connection portion connecting the distal end of the coil body to the distal end of the core shaft, and a proximal connection portion connecting the proximal end of the coil body to the core shaft and containing an adhesive made of a resin material.

[0008] According to the guidewire of the first aspect, the guidewire can be made flexible, which improves the ease of insertion of the guidewire into the patient's body.

[0009] A guide wire according to a second aspect may be the guide wire according to the first aspect, wherein the coil body is wound multiple times around the outer circumference of the core shaft, and the base end connection portion between adjacent wires of the coil body may be formed with an outer diameter smaller than the outer diameter of the coil body.

[0010] According to the guidewire of the second aspect, the guidewire can be made even more flexible, which further improves the ease of insertion of the guidewire into the patient's body.

[0011] A guidewire according to a third aspect is the guidewire according to the first or second aspect, wherein the proximal end connection portion may be colored.

[0012] According to the guidewire of the third aspect, the length of the proximal end connection part connected to the coil body can be easily determined, and therefore the joining strength between the core shaft and the coil body can be easily adjusted.

[0013] The guide wire of the fourth aspect is a guide wire of any one of the first to third aspects, which includes an intermediate connecting portion between the tip connecting portion and the base connecting portion, which connects the coil body and the core shaft, and the intermediate connecting portion may contain an adhesive made of a resin material.

[0014] According to the guidewire of the fourth aspect, the coil body and the core shaft can be connected midway between the distal and proximal ends of the coil body, making the guidewire flexible and improving the ease of insertion of the guidewire into the patient's body.

[0015] A guide wire according to a fifth aspect may be the guide wire according to the fourth aspect, wherein the coil body is wound multiple times around the outer circumference of the core shaft, and the intermediate connection portion between adjacent wires of the coil body may be formed with an outer diameter smaller than the outer diameter of the coil body.

[0016] According to the guidewire of the fifth aspect, the guidewire can be made even more flexible, which further improves the ease of insertion of the guidewire into the patient's body.

[0017] A guidewire according to a sixth aspect is the guidewire of the fourth or fifth aspect, wherein the intermediate connector may be colored.

[0018] According to the guidewire of the sixth aspect, the length of the intermediate joint connected to the coil body can be easily determined, and therefore the joining strength between the core shaft and the coil body can be easily adjusted.

[0019] A guidewire according to a seventh aspect is the guidewire of any one of the first to sixth aspects, wherein the surface roughness of the coil body may be greater than the surface roughness of the core shaft.

[0020] According to the guide wire of the seventh aspect, even if a large force is applied to the guide wire and the coil body comes off from the core shaft, the base end connecting portion comes off while still connected to the coil body, preventing the base end connecting portion from shattering and scattering.

[0021] The guidewire according to an eighth aspect is the guidewire according to any one of the first to seventh aspects, wherein an oxide coating is formed on the surface of the coil body.

[0022] According to the guide wire of the eighth aspect, even if a large force is applied to the guide wire and the coil body comes off from the core shaft, the base end connecting portion comes off while still connected to the coil body, thereby preventing the base end connecting portion from shattering and flying away.

[0023] A guide wire according to a ninth aspect is a guide wire according to any one of the first to eighth aspects, wherein a plurality of grooves are formed on the surface of the coil body in a direction intersecting the longitudinal direction of the core shaft.

[0024] According to the guide wire of the ninth aspect, even if a large force is applied to the guide wire and the coil body comes off from the core shaft, the base end connecting portion comes off while still connected to the coil body, preventing the base end connecting portion from shattering and scattering.

[0025] The guide wire according to the tenth aspect may be the guide wire of any one of the first to ninth aspects, wherein a plurality of grooves are formed on the surface of the core shaft in a direction intersecting the longitudinal direction of the core shaft.

[0026] According to the guide wire of the tenth aspect, even if a large force is applied to the guide wire and the coil body comes off from the core shaft, the base end connecting portion comes off while still connected to the coil body, preventing the base end connecting portion from shattering and scattering.

[0027] The guide wire according to an eleventh aspect may be the guide wire of any one of the first to ninth aspects, wherein a plurality of grooves are formed on the surface of the core shaft along the longitudinal direction of the core shaft.

[0028] According to the guide wire of the eleventh aspect, even if a large force is applied to the guide wire and the coil body comes off from the core shaft, the base end connecting portion comes off while still connected to the core shaft, thereby preventing the base end connecting portion from shattering and scattering.

[0029] The connection structure of the twelfth aspect connects the surface of a first member having a first surface roughness to the surface of a second member having a second surface roughness greater than the first surface roughness using an adhesive made of a resin material.

[0030] According to the connection structure of the twelfth aspect, even if a large force is applied to the connection structure and the second member comes off from the first member, the adhesive comes off while still connected to the second member, preventing the adhesive from breaking and scattering.

[0031] The connection structure according to the thirteenth aspect connects a surface of a first member on which no oxide film is formed and a surface of a second member on which an oxide film is formed using an adhesive made of a resin material.

[0032] According to the connection structure of the thirteenth aspect, even if a large force is applied to the connection structure and the second member comes off from the first member, the adhesive comes off while still connected to the second member, preventing the adhesive from breaking and scattering.

[0033] FIG. 1 is an overall schematic view of a guidewire of a first embodiment. FIG. 2 is an enlarged view of a distal end of the guidewire of the first embodiment. FIG. 3 is a longitudinal cross-sectional view of a distal end of the guidewire of the first embodiment. FIG. 4 is a longitudinal cross-sectional view of a distal end of the guidewire of a second embodiment. FIG. 5 is a longitudinal cross-sectional view of a distal end of the guidewire of a third embodiment. FIG. 6 is a longitudinal cross-sectional view of a distal end of the guidewire of a fourth embodiment. FIG. 7 is a longitudinal cross-sectional view of a distal end of the guidewire of a fifth embodiment. FIG. 8 is a longitudinal cross-sectional view of a distal end of the guidewire of a sixth embodiment. FIG. 9 is an enlarged view of a portion A in FIG. 8. FIG. 10 is an enlarged view of a distal end of the guidewire of the sixth embodiment, showing a state in which the coil body has been detached from the core shaft. FIG. 11 is a longitudinal cross-sectional view of a distal end of the guidewire of a seventh embodiment. FIG. 12 is an enlarged view of a portion B in FIG. 11. FIG. 13 is an enlarged view of a distal end of the guidewire of an eighth embodiment. FIG. 14 is a partial enlarged view of a guidewire of a ninth embodiment. FIG. 15 is a partial enlarged view of a guidewire of a tenth embodiment.

[0034] Hereinafter, several embodiments of the present disclosure will be described with reference to the drawings. The drawings used in the following embodiments are exaggerated for ease of understanding, and the dimensions differ from the actual dimensions. Parts common to each embodiment are assigned the same reference numerals, and descriptions of parts that have already been described may be omitted.

[0035] First Embodiment A first embodiment of the present disclosure will be described.

[0036] FIG. 1 is a schematic view of the entire guide wire of the first embodiment, FIG. 2 is an enlarged view of the distal end of the guide wire of the first embodiment, and FIG. 3 is a longitudinal cross-sectional view of the distal end of the guide wire of the first embodiment.

[0037] As shown in Figures 1 to 3, the guide wire 1 of this embodiment includes a core shaft 9, a coil body 3 covering the distal end of the core shaft 9, a distal connection part 2 connected to the distal end of the coil body 3 and the distal end of the core shaft 9, a proximal connection part 5 connected to the proximal end of the coil body 3 and the core shaft 9, and a coating agent 8 covering the outer peripheries of the core shaft 9, the coil body 3, the distal connection part 2, and the proximal connection part 5.

[0038] The core shaft 9 is an elongated flexible member having a generally circular cross section and a diameter that decreases from the base end to the tip. The core shaft 9 includes a generally cylindrical base end cylindrical portion 9c, a tapered tip portion 9b that extends from the tip of the base end cylindrical portion 9c to the tip end and gradually decreases in diameter toward the tip, and a generally cylindrical tip cylindrical portion 9a that extends from the tip of the tapered tip portion 9b to the tip end.

[0039] The material of the core shaft 9 is not particularly limited as long as it is a biocompatible material, such as a metal material such as stainless steel, a Ni-Ti alloy, or a cobalt alloy, or a synthetic resin material such as polyethylene, polyethylene terephthalate, polypropylene, polyurethane, or polyvinyl chloride. In this embodiment, the material of the core shaft 9 is, for example, stainless steel.

[0040] The coil body 3 is a hollow cylindrical coil body formed by winding one or more metal wires or resin wires. The tip of the coil body 3 is connected to the tip of the core shaft 9 by a tip connecting part 2, and the base end of the coil body 3 is connected to the core shaft 9 by a base end connecting part 5.

[0041] The material of the wires forming the coil body 3 is not particularly limited as long as it is a biocompatible material, such as metal materials such as stainless steel, Ni-Ti alloys, and cobalt alloys, and synthetic resin materials such as polyethylene, polyethylene terephthalate, polypropylene, polyurethane, and polyvinyl chloride. In this embodiment, the material of the wires is stainless steel.

[0042] As shown in FIG. 3 , a gap 4 is formed between the core shaft 9 and the coil body 3 .

[0043] The tip connection part 2 joins the tip of the coil body 3 and the tip of the core shaft 9. The material of the tip connection part 2 is not particularly limited as long as it is a biocompatible joining material such as gold-tin solder or silver-tin solder. In this embodiment, the material of the tip connection part 2 is silver-tin solder.

[0044] The proximal end connecting portion 5 joins the proximal end of the coil body 3 and the core shaft 9. The material of the proximal end connecting portion 5 is not particularly limited as long as it is a biocompatible joining member made of a resin material, such as a silicone adhesive, an acrylic adhesive, an epoxy adhesive, or a cyanoacrylate adhesive. In this embodiment, the material of the proximal end connecting portion 5 is an epoxy adhesive.

[0045] The coating agent 8 covers the outer peripheries of the core shaft 9, the coil body 3, the distal connecting portion 2, and the proximal connecting portion 5. Desirable materials for the coating agent 8 include, for example, polyvinyl alcohol, polyvinylpyrrolidone, polyethylene glycol, polyacrylamide, polyacrylic acid, sodium polyacrylate, poly(2-hydroxyethyl methacrylate), maleic anhydride copolymers, ethylene-vinyl alcohol copolymers, 2-methacryloyloxyethyl phosphorylcholine, 2-methacryloyloxyethyl phosphorylcholine copolymers, (2-hydroxyethyl methacrylate)-styrene block copolymers, various synthetic polypeptides, collagen, hyaluronic acid, cellulose-based polymers, and mixtures thereof. In this embodiment, the material for the coating agent 8 is polyacrylamide.

[0046] In this embodiment, the adhesive made of a resin material is described as being used only for the base end connecting part 5. The tip connecting part 2 may also use an adhesive made of the same resin material as the base end connecting part 5, provided that sufficient bonding strength is ensured.

[0047] The fact that the distal end connecting portion 2 can use an adhesive made of the same resin material as the proximal end connecting portion 5 applies not only to this embodiment but also to the embodiments described below.

[0048] The guidewire 1 of this embodiment includes a core shaft 9, a coil body 3 covering the distal end of the core shaft 9, a distal connection portion 2 connecting the distal end of the coil body 3 to the distal end of the core shaft 9, and a proximal connection portion 5 connecting the proximal end of the coil body 3 to the core shaft 9. The proximal connection portion 5 is made of an adhesive made of a resin material, which makes the guidewire 1 flexible. This improves the insertability of the guidewire 1 into the patient's body.

[0049] Second Embodiment A second embodiment will be described.

[0050] The guidewire 10 of the second embodiment differs from the guidewire 1 of the first embodiment in the number of connecting portions connecting the coil body and the core shaft. That is, the guidewire 1 of the first embodiment includes two connecting portions: a distal connecting portion 2 connecting the distal end of the coil body 3 to the distal end of the core shaft 9, and a proximal connecting portion 5 connecting the proximal end of the coil body 3 to the core shaft 9. In addition to the distal connecting portion and the proximal connecting portion, the guidewire 10 of the present embodiment includes an intermediate connecting portion that is disposed between the distal connecting portion and the proximal connecting portion in the longitudinal direction of the guidewire and connects the coil body to the core shaft.

[0051] FIG. 4 is a longitudinal cross-sectional view of the distal end of the guide wire of the second embodiment.

[0052] The guidewire 10 of this embodiment includes a core shaft 9, a coil body 3 covering the distal end of the core shaft 9, a distal connection portion 2 connected to the distal end of the coil body 3 and the distal end of the core shaft 9, a proximal connection portion 5 connected to the proximal end of the coil body 3 and the core shaft 9, a plurality of intermediate connection portions 7, i.e., distal intermediate connection portions 7a and proximal intermediate connection portions 7b, arranged between the distal connection portion 2 and the proximal connection portion 5 in the longitudinal direction of the guidewire 10 and connected to the coil body 3 and the core shaft 9, and a coating agent 18 covering the outer peripheries of the core shaft 9, the coil body 3, the distal connection portion 2, the proximal connection portion 5, the distal intermediate connection portion 7a, and the proximal intermediate connection portion 7b.

[0053] A gap 14 is formed between the core shaft 9 and the coil body 3 .

[0054] The distal intermediate connector 7a is disposed between the distal connector 2 and the proximal connector 5 in the longitudinal direction of the guidewire 10, and connects the coil body 3 and the core shaft 9. The material of the distal intermediate connector 7a is not particularly limited as long as it is a biocompatible joining member made of a resin material, such as a silicone adhesive, an acrylic adhesive, an epoxy adhesive, or a cyanoacrylate adhesive. In this embodiment, the material of the distal intermediate connector 7a is an epoxy adhesive.

[0055] The proximal intermediate connecting part 7b is disposed between the distal connecting part 2 and the proximal connecting part 5 in the longitudinal direction of the guidewire 10, and connects the coil body 3 and the core shaft 9 on the proximal side of the distal intermediate connecting part 7a. The material of the proximal intermediate connecting part 7b is not particularly limited as long as it is a biocompatible joining member made of a resin material, such as a silicone adhesive, an acrylic adhesive, an epoxy adhesive, or a cyanoacrylate adhesive, as with the proximal connecting part 5. In this embodiment, the material of the proximal intermediate connecting part 7b is an epoxy adhesive.

[0056] 4, the present embodiment includes two intermediate connectors: a distal intermediate connector 7a and a proximal intermediate connector 7b. The number of intermediate connectors is not limited to two, and may be one, or three or more.

[0057] The coating agent 18 covers the outer peripheries of the core shaft 9, the coil body 3, the distal connecting portion 2, the proximal connecting portion 5, the distal intermediate connecting portion 7 a, and the proximal intermediate connecting portion 7 b. The material of the coating agent 18 may be the same as the material of the coating agent 8 in the first embodiment, and in this embodiment, it is polyacrylamide.

[0058] The guidewire 10 of this embodiment includes a core shaft 9, a coil body 3 covering the distal end of the core shaft 9, a distal connection portion 2 connecting the distal end of the coil body 3 to the distal end of the core shaft 9, and a proximal connection portion 5 connecting the proximal end of the coil body 3 to the core shaft 9, and the proximal connection portion 5 is made of an adhesive made of a resin material, which makes the guidewire 10 flexible. This improves the insertability of the guidewire 10 into the patient's body.

[0059] The guidewire 10 of this embodiment includes an intermediate connector 7 that connects the coil body 3 and the core shaft 9 between the distal connector 2 and the proximal connector 5, and the intermediate connector 7 is made of an adhesive made of a resin material, which makes the guidewire 10 flexible. This improves the insertability of the guidewire 10 into the patient's body.

[0060] Third Embodiment A third embodiment will be described.

[0061] The guidewire 20 of the third embodiment differs from the guidewire 1 of the first embodiment in the configuration of the proximal-end connecting portion. That is, while the outer diameter of the proximal-end connecting portion 5 in the guidewire 1 of the first embodiment was substantially uniform between the wires constituting the coil body 3, the outer diameter of the proximal-end connecting portion in the guidewire 20 of the present embodiment is smaller than the outer diameter of the coil body between the wires constituting the coil body.

[0062] FIG. 5 is a longitudinal cross-sectional view of the distal end of a guide wire according to a third embodiment.

[0063] The guide wire 20 of this embodiment includes a core shaft 9, a coil body 23 covering the tip of the core shaft 9, a tip connection portion 22 connected to the tip of the coil body 23 and the tip of the core shaft 9, a base end connection portion 25 connected to the base end of the coil body 23 and the core shaft 9, and a coating agent 28 covering the outer peripheries of the core shaft 9, the coil body 23, the tip connection portion 22, and the base end connection portion 25.

[0064] A gap 24 is formed between the core shaft 9 and the coil body 23 .

[0065] The coil body 23 is a hollow cylindrical coil body formed by winding one or more metal wires or resin wires. The coil body 23 is wound multiple times around the outer periphery of the core shaft 9. The tip of the coil body 23 is connected to the tip of the core shaft 9 by a tip connecting portion 22, and the base end of the coil body 23 is connected to the core shaft 9 by a base end connecting portion 25.

[0066] The wire material forming the coil body 23 can be the same as that of the coil body 3 of the first embodiment. In this embodiment, the wire material forming the coil body 23 is stainless steel.

[0067] The tip connection part 22 joins the tip of the coil body 23 and the tip of the core shaft 9. The material of the tip connection part 22 can be the same as that of the tip connection part 2 of the first embodiment. In this embodiment, the material of the tip connection part 22 is a silver-tin brazing material.

[0068] The base end connecting portion 25 joins the base end of the coil body 23 to the core shaft 9. The outer diameter R1 of the base end connecting portion 25 between the wires that make up the coil body 23 is smaller than the outer diameter R2 of the coil body 23.

[0069] The base end connecting part 25 can be made of the same material as the base end connecting part 5 of the first embodiment. In this embodiment, the base end connecting part 25 is made of an epoxy adhesive.

[0070] In this embodiment, the longitudinal width of the base end connecting portion 25 is formed across the two wires that make up the coil body 23, and there is one portion in the base end connecting portion 25 where the outer diameter R1 is smaller than the outer diameter R2 of the coil body 23. The longitudinal width of the base end connecting portion 25 may be formed across any number of wires of the coil body 23. The portions in the base end connecting portion 25 where the outer diameter R1 is smaller than the outer diameter R2 of the coil body 23 may be formed in multiple locations.

[0071] The coating agent 28 covers the outer peripheries of the core shaft 9, the coil body 23, the distal connection portion 22, and the proximal connection portion 25. The material of the coating agent 28 can be the same as the material of the coating agent 8 in the first embodiment. In this embodiment, the material of the coating agent 28 is polyacrylamide.

[0072] The guidewire 20 of this embodiment includes a core shaft 9, a coil body 23 covering the distal end of the core shaft 9, a distal connection portion 22 connecting the distal end of the coil body 23 to the distal end of the core shaft 9, and a proximal connection portion 25 connecting the proximal end of the coil body 23 to the core shaft 9. The proximal connection portion 25 is made of an adhesive made of a resin material, which makes the guidewire 20 flexible. This improves the insertability of the guidewire 20 into the patient's body.

[0073] According to the guidewire 20 of this embodiment, the coil body 23 is wound multiple times around the outer periphery of the core shaft 9, and the proximal connection portion 25 between adjacent strands of the coil body 23 is formed with an outer diameter smaller than the outer diameter of the coil body 23, thereby making the guidewire 20 even more flexible. This further improves the insertability of the guidewire 20 into the patient's body.

[0074] Fourth Embodiment A fourth embodiment will be described.

[0075] The guidewire 30 of the fourth embodiment differs from the guidewire 20 of the third embodiment in the number of connecting portions connecting the coil body and the core shaft. That is, the guidewire 20 of the third embodiment has two connecting portions: a distal connecting portion 22 connecting the distal end of the coil body 23 to the distal end of the core shaft 9, and a proximal connecting portion 25 connecting the proximal end of the coil body 23 to the core shaft 9. In addition to the distal connecting portion and the proximal connecting portion, the guidewire 30 of this embodiment has an intermediate connecting portion that is disposed between the distal connecting portion and the proximal connecting portion in the longitudinal direction of the guidewire and connects the coil body to the core shaft.

[0076] FIG. 6 is a longitudinal cross-sectional view of the distal end of a guide wire according to a fourth embodiment.

[0077] The guide wire 30 of this embodiment includes a core shaft 9, a coil body 23 covering the tip of the core shaft 9, a tip connection portion 22 connected to the tip of the coil body 23 and the tip of the core shaft 9, a base end connection portion 35 connected to the base end of the coil body 23 and the core shaft 9, an intermediate connection portion 37 arranged between the tip connection portion 22 and the base end connection portion 35 in the longitudinal direction of the guide wire 30 and connected to the coil body 23 and the core shaft 9, and a coating agent 38 covering the outer periphery of the core shaft 9, the coil body 23, the tip connection portion 22, the base end connection portion 35, and the intermediate connection portion 37.

[0078] A gap 34 is formed between the core shaft 9 and the coil body 23 .

[0079] The base end connecting portion 35 joins the base end of the coil body 23 to the core shaft 9. The outer diameter R3 of the base end connecting portion 35 between the wires that make up the coil body 23 is smaller than the outer diameter R2 of the coil body 23.

[0080] The base end connecting portion 35 can be made of the same material as the base end connecting portion 5 of the first embodiment. In this embodiment, the base end connecting portion 35 is made of an epoxy adhesive.

[0081] The intermediate connecting portion 37 is disposed between the distal connecting portion 22 and the proximal connecting portion 35 in the longitudinal direction of the guidewire 30, and connects the coil body 23 to the core shaft 9. The outer diameter R4 of the intermediate connecting portion 37 is smaller than the outer diameter R2 of the coil body 23 between the wires that make up the coil body 23.

[0082] The intermediate connector 37 may be made of the same material as the distal intermediate connector 7 a and the proximal intermediate connector 7 b of the second embodiment. In this embodiment, the intermediate connector 37 is made of an epoxy adhesive.

[0083] In this embodiment, there is one intermediate connecting portion 37. The number of intermediate connecting portions 37 is not limited to one, and may be two or more.

[0084] In this embodiment, the longitudinal width of the base end connecting portion 35 is formed across the two wires that make up the coil body 23, and there is one portion in the base end connecting portion 35 where the outer diameter R3 is smaller than the outer diameter R2 of the coil body 23. The longitudinal width of the base end connecting portion 35 may be formed across any number of wires of the coil body 23. The portions in the base end connecting portion 35 where the outer diameter R3 is smaller than the outer diameter R2 of the coil body 23 may be formed in multiple locations.

[0085] In this embodiment, the longitudinal width of the intermediate connection part 37 is formed across the three wires that make up the coil body 23, and there are two portions in the intermediate connection part 37 that have an outer diameter R4 that is smaller than the outer diameter R2 of the coil body 23. The longitudinal width of the intermediate connection part 37 may be formed across any number of wires in the coil body 23. There may be one portion in the intermediate connection part 37 that has an outer diameter R4 that is smaller than the outer diameter R2 of the coil body 23, or there may be three or more portions in the intermediate connection part 37 that have an outer diameter R4 that is smaller than the outer diameter R2 of the coil body 23.

[0086] The coating agent 38 covers the outer peripheries of the core shaft 9, the coil body 23, the distal connecting portion 22, the proximal connecting portion 35, and the intermediate connecting portion 37. The material of the coating agent 38 can be the same as the material of the coating agent 8 in the first embodiment. In this embodiment, the material of the coating agent 38 is polyacrylamide.

[0087] The guidewire 30 of this embodiment includes a core shaft 9, a coil body 23 covering the distal end of the core shaft 9, a distal connection portion 22 connecting the distal end of the coil body 23 to the distal end of the core shaft 9, and a proximal connection portion 35 connecting the proximal end of the coil body 23 to the core shaft 9. The proximal connection portion 35 is made of an adhesive made of a resin material, which makes the guidewire 30 flexible. This improves the insertability of the guidewire 30 into the patient's body.

[0088] According to the guidewire 30 of this embodiment, an intermediate connector 37 that connects the coil body 23 and the core shaft 9 is provided between the distal connector 22 and the proximal connector 35, and the intermediate connector 37 is made of an adhesive made of a resin material, which makes the guidewire 30 flexible. This improves the insertability of the guidewire 30 into the patient's body.

[0089] According to the guidewire 30 of this embodiment, the coil body 23 is wound multiple times around the outer periphery of the core shaft 9, and the proximal connection portion 35 between adjacent strands of the coil body 23 is formed with an outer diameter smaller than the outer diameter of the coil body 23, thereby making the guidewire 30 even more flexible. This further improves the insertability of the guidewire 30 into the patient's body.

[0090] Furthermore, according to the guide wire 30 of this embodiment, the coil body 23 is wound multiple times around the outer periphery of the core shaft 9, and at least one intermediate connection portion 37 is formed between adjacent wires that make up the coil body 23 at a position lower than the outer diameter of the coil body 23, thereby making the guide wire 30 even more flexible and ultimately further improving the insertability of the guide wire 30 into the patient's body.

[0091] Fifth Embodiment A fifth embodiment will be described.

[0092] The guidewire 40 of the fifth embodiment has a different color for the proximal connection portion and the intermediate connection portion compared to the guidewire 30 of the fourth embodiment. That is, the proximal connection portion 35 and the intermediate connection portion 37 of the guidewire 30 of the fourth embodiment are colorless and transparent, whereas the proximal connection portion and the intermediate connection portion of the guidewire 40 of the present embodiment are colored.

[0093] In this embodiment, "colored" refers to magenta, cyan, yellow, black, and colors formed by combining these colors.

[0094] By coloring the base end connection part, the length of the base end connection part connected to the coil body can be easily grasped, and the joining strength between the core shaft and the coil body can be easily adjusted. By coloring the intermediate connection part, the length of the intermediate connection part connected to the coil body can be easily grasped, and the joining strength between the core shaft and the coil body can be easily adjusted.

[0095] This is based on the theory that, because the winding pitch of the coil body relative to the core shaft is known in advance when the guidewire is manufactured, the number of strands of the coil body housed in the base-end connecting part and intermediate connecting part can be adjusted by adjusting the longitudinal lengths of the guidewire of the base-end connecting part and intermediate connecting part connected to the coil body, and thereby the joint strength between the core shaft and the coil body. Therefore, if the length of the intermediate connecting part connected to the coil body can be easily determined, the joint strength between the core shaft and the coil body can be easily determined.

[0096] Fig. 7 is a longitudinal cross-sectional view of the distal end of the guide wire according to the fifth embodiment, in which colored portions are indicated by hatching.

[0097] The guide wire 40 of this embodiment includes a core shaft 9, a coil body 23 covering the tip of the core shaft 9, a tip connection portion 22 connected to the tip of the coil body 23 and the tip of the core shaft 9, a base end connection portion 45 connected to the base end of the coil body 23 and the core shaft 9, an intermediate connection portion 47 arranged between the tip connection portion 22 and the base end connection portion 45 in the longitudinal direction of the guide wire 40 and connected to the coil body 23 and the core shaft 9, and a coating agent 48 covering the outer periphery of the core shaft 9, the coil body 23, the tip connection portion 22, the base end connection portion 45, and the intermediate connection portion 47.

[0098] A gap 44 is formed between the core shaft 9 and the coil body 23 .

[0099] The base end connecting portion 45 joins the base end of the coil body 23 to the core shaft 9. The outer diameter of the base end connecting portion 45 is smaller than the outer diameter of the coil body 23 between the wires that make up the coil body 23.

[0100] The material of the proximal end connecting part 45 can be the same as that of the proximal end connecting part 5 of the first embodiment, but containing a pigment. In this embodiment, the material of the proximal end connecting part 45 is an epoxy adhesive containing a biocompatible ink whose main components are hydroxypropyl cellulose (HPC) and gelatin. In another aspect, the material of the proximal end connecting part 45 may contain a component that emits light when irradiated with ultraviolet light. In this case, the proximal end connecting part 45 may be colorless or colored under visible light. Examples of such components include epoxy resin, acrylic resin, etc., and may be resins that have an absorption peak at ultraviolet wavelengths.

[0101] The intermediate connecting portion 47 is disposed between the distal connecting portion 22 and the proximal connecting portion 45 in the longitudinal direction of the guide wire 40, and connects the coil body 23 to the core shaft 9. The outer diameter of the intermediate connecting portion 47 is smaller than the outer diameter of the coil body 23 between the wires that make up the coil body 23.

[0102] The intermediate connector 47 may be made of the same material as the distal intermediate connector 7 a and the proximal intermediate connector 7 b of the second embodiment, but containing a pigment. In this embodiment, the intermediate connector 47 is made of an epoxy adhesive containing a biocompatible ink primarily composed of hydroxypropyl cellulose (HPC) and gelatin, similar to the material of the proximal connector 45. Alternatively, the intermediate connector 47 may contain a component that emits light when irradiated with ultraviolet light. In this case, the intermediate connector 47 may be colorless or colored under visible light. Examples of such components include epoxy resin, acrylic resin, and the like, which may have an absorption peak at ultraviolet wavelengths.

[0103] In this embodiment, there is one intermediate connector 47. The number of intermediate connectors 47 is not limited to one, and may be two or more.

[0104] In this embodiment, the longitudinal width of the base end connecting portion 35 is formed across the two wires that make up the coil body 23, and the portion with an outer diameter smaller than the outer diameter of the coil body 23 is located at one point in the base end connecting portion 45. The longitudinal width of the base end connecting portion 45 may be formed across any number of wires of the coil body 23. The portion with an outer diameter smaller than the outer diameter of the coil body 23 may be formed at multiple points in the base end connecting portion 45.

[0105] The longitudinal width of intermediate connection part 47 is formed across the three wires that make up coil body 23, and there are two portions in intermediate connection part 47 that have an outer diameter smaller than the outer diameter of coil body 23. The longitudinal width of intermediate connection part 47 may be formed across any number of wires of coil body 23. There may be one portion in intermediate connection part 47 that has an outer diameter smaller than the outer diameter of coil body 23, or there may be three or more portions in intermediate connection part 47 that have an outer diameter smaller than the outer diameter of coil body 23.

[0106] The coating agent 48 covers the outer peripheries of the core shaft 9, the coil body 23, the distal connecting portion 22, the proximal connecting portion 45, and the intermediate connecting portion 47. The material of the coating agent 48 can be the same as the material of the coating agent 8 in the first embodiment. In this embodiment, the material of the coating agent 48 is polyacrylamide.

[0107] The guidewire 40 of this embodiment includes a core shaft 9, a coil body 23 covering the distal end of the core shaft 9, a distal connection portion 22 connecting the distal end of the coil body 23 to the distal end of the core shaft 9, and a proximal connection portion 45 connecting the proximal end of the coil body 23 to the core shaft 9, and the proximal connection portion 45 is made of an adhesive made of a resin material, which makes the guidewire 40 flexible. This improves the insertability of the guidewire 40 into the patient's body.

[0108] According to the guidewire 40 of this embodiment, an intermediate connecting portion 47 that connects the coil body 23 and the core shaft 9 is provided between the distal connecting portion 22 and the proximal connecting portion 45, and the intermediate connecting portion 47 is made of an adhesive made of a resin material, which makes the guidewire 40 flexible. This improves the insertability of the guidewire 40 into the patient's body.

[0109] According to the guidewire 40 of this embodiment, the coil body 23 is wound multiple times around the outer periphery of the core shaft 9, and the proximal connection portion 45 between adjacent strands of the coil body 23 is formed with an outer diameter smaller than the outer diameter of the coil body 23, thereby making the guidewire 40 even more flexible. This further improves the insertability of the guidewire 40 into the patient's body.

[0110] According to the guidewire 40 of this embodiment, the coil body 23 is wound multiple times around the outer periphery of the core shaft 9, and the intermediate joints 47 between adjacent strands of the coil body 23 are formed with an outer diameter smaller than the outer diameter of the coil body 23, thereby making the guidewire 40 even more flexible. This further improves the insertability of the guidewire 40 into the patient's body.

[0111] According to the guidewire 40 of this embodiment, the proximal end connecting portion 45 is colored, so that the length X2 of the proximal end connecting portion 45 connected to the coil body 23 in the longitudinal direction of the guidewire 40 can be easily grasped. Therefore, the joining strength between the core shaft 9 and the coil body 23 can be easily adjusted.

[0112] According to the guide wire 40 of the present embodiment, the intermediate connector 47 is colored, so that the length X1 of the intermediate connector 47 connected to the coil body 23 in the longitudinal direction of the guide wire 40 can be easily grasped. Therefore, the joining strength between the core shaft 9 and the coil body 23 can be easily adjusted.

[0113] Sixth Embodiment A sixth embodiment will be described.

[0114] The guidewire 50 of the sixth embodiment differs from the guidewire 30 of the fourth embodiment in the connection between the coil body and the proximal connection portion and the connection between the coil body and the intermediate connection portion. That is, unlike the guidewire 30 of the fourth embodiment, the guidewire 50 of the present embodiment has a larger surface roughness of the coil body than the surface roughness of the core shaft.

[0115] Figure 8 is a longitudinal cross-sectional view of the distal end of the guide wire of the sixth embodiment, Figure 9 is an enlarged view of part A in Figure 8, and Figure 10 is an enlarged view of the distal end of the guide wire of the sixth embodiment, showing the state in which the coil body has been detached from the core shaft.

[0116] As shown in Figures 8 and 9, the guide wire 50 of this embodiment includes a core shaft 9, a coil body 53 covering the distal end of the core shaft 9, a distal connection portion 52 connected to the distal end of the coil body 53 and the distal end of the core shaft 9, a proximal connection portion 55 connected to the proximal end of the coil body 53 and the core shaft 9, an intermediate connection portion 57 arranged between the distal connection portion 52 and the proximal connection portion 55 in the longitudinal direction of the guide wire 50 and connected to the coil body 53 and the core shaft 9, and a coating agent 58 covering the outer peripheries of the core shaft 9, the coil body 53, the distal connection portion 52, the proximal connection portion 55, and the intermediate connection portion 57.

[0117] A gap 54 is formed between the core shaft 9 and the coil body 53 .

[0118] The coil body 53 is a hollow cylindrical coil body formed by winding one or more metal wires or resin wires. The coil body 53 is wound multiple times around the outer periphery of the core shaft 9. The tip of the coil body 53 is connected to the tip of the core shaft 9 by a tip connecting portion 52, and the base end of the coil body 53 is connected to the core shaft 9 by a base end connecting portion 55.

[0119] The surface roughness of the wire constituting the coil body 53 is greater than the surface roughness of the core shaft 9. The wire constituting the coil body 53 has unevenness 53a formed on its surface by processing means such as sandblasting.

[0120] The wire material forming the coil body 53 can be the same as that of the coil body 3 of the first embodiment. In this embodiment, the wire material of the coil body 53 is stainless steel.

[0121] The tip connection part 52 joins the tip of the coil body 53 and the tip of the core shaft 9. The material of the tip connection part 52 can be the same as that of the tip connection part 2 of the first embodiment. In this embodiment, the material of the tip connection part 52 is a silver-tin brazing material.

[0122] The base end connecting portion 55 joins the base end of the coil body 53 to the core shaft 9. As shown in Figures 8 and 9, the outer diameter of the base end connecting portion 55 is smaller than the outer diameter of the coil body 53 between the wires that make up the coil body 53.

[0123] The base end connecting portion 55 can be made of the same material as the base end connecting portion 5 of the first embodiment. In this embodiment, the base end connecting portion 55 is made of an epoxy adhesive.

[0124] The intermediate connecting portion 57 is disposed between the distal connecting portion 52 and the proximal connecting portion 55 in the longitudinal direction of the guidewire 50, and connects the coil body 53 to the core shaft 9. As shown in Figures 8 and 9, the outer diameter of the intermediate connecting portion 47 is smaller than the outer diameter of the coil body 23 between the wires that make up the coil body 23.

[0125] The intermediate connector 47 may be made of the same material as the distal intermediate connector 7 a and the proximal intermediate connector 7 b of the second embodiment. In this embodiment, the intermediate connector 47 is made of an epoxy adhesive.

[0126] 8, in this embodiment as well, there is one intermediate connector 57. The number of intermediate connectors 57 is not limited to one, and may be two or more.

[0127] 8 , in this embodiment, the longitudinal width of the base end connecting portion 55 is formed across two wires that make up the coil body 53, and there is one portion in the base end connecting portion 55 that has an outer diameter smaller than the outer diameter of the coil body 53. The longitudinal width of the base end connecting portion 55 may be formed across any number of wires that make up the coil body 53. The portion in the base end connecting portion 55 that has an outer diameter smaller than the outer diameter of the coil body 53 may be formed in multiple locations.

[0128] The longitudinal width of intermediate connection part 57 is formed across the three wires that make up coil body 53, and there are two portions in intermediate connection part 57 that have an outer diameter smaller than the outer diameter of coil body 53. The longitudinal width of intermediate connection part 57 may be formed across any number of wires of coil body 53. The portions in intermediate connection part 57 that have an outer diameter smaller than the outer diameter of coil body 53 may be formed in one portion or in more than one portion.

[0129] The coating agent 58 covers the outer peripheries of the core shaft 9, the coil body 53, the distal connecting portion 52, the proximal connecting portion 55, and the intermediate connecting portion 57. The material of the coating agent 58 can be the same as the material of the coating agent 8 in the first embodiment. In this embodiment, the material of the coating agent 58 is polyacrylamide.

[0130] In the guidewire 50 described above, in the event that the coil body 53 becomes detached from the core shaft 9 during a procedure, the surface roughness of the wires constituting the coil body 53 is set to be greater than the surface roughness of the core shaft 9. As a result, as shown in Fig. 10, the intermediate connecting part 57 or the base-end connecting part 55 will become detached from the core shaft 9 together with the coil body 53, and it is possible to prevent at least one of the intermediate connecting part 57 itself and the base-end connecting part 55 itself from being broken and leaking into the lumen of the patient's blood vessel or the like.

[0131] As in the guide wire 50 of this embodiment, the surface roughness of the coil body 53 is made larger than the surface roughness of the core shaft 9, and the coil body 53 and the core shaft 9 are connected with an adhesive made of a resin material. This can be applied to a connection structure in which the surface of a first member having a predetermined first surface roughness is connected to the surface of a second member having a second surface roughness larger than the first surface roughness with an adhesive made of a resin material.

[0132] In this case, even if a large force is applied to the connection structure and the second member comes off from the first member, the adhesive comes off while still connected to the second member, preventing the adhesive itself from being crushed and scattered.

[0133] The guidewire 50 of this embodiment includes a core shaft 9, a coil body 53 covering the distal end of the core shaft 9, a distal connection portion 52 connecting the distal end of the coil body 53 to the distal end of the core shaft 9, and a proximal connection portion 55 connecting the proximal end of the coil body 53 to the core shaft 9, and the proximal connection portion 55 is made of an adhesive made of a resin material, which makes the guidewire 50 flexible. This improves the insertability of the guidewire 50 into the patient's body.

[0134] According to the guidewire 50 of this embodiment, an intermediate connecting portion 57 that connects the coil body 53 and the core shaft 9 is provided between the distal connecting portion 52 and the proximal connecting portion 55, and the intermediate connecting portion 57 is made of an adhesive made of a resin material, which makes the guidewire 50 flexible. This improves the insertability of the guidewire 50 into the patient's body.

[0135] According to the guidewire 50 of this embodiment, the coil body 53 is wound multiple times around the outer periphery of the core shaft 9, and the proximal connection portion 55 between adjacent strands of the coil body 23 is formed with an outer diameter smaller than the outer diameter of the coil body 53, thereby making the guidewire 50 even more flexible. This further improves the insertability of the guidewire 50 into the patient's body.

[0136] According to the guidewire 50 of this embodiment, the coil body 53 is wound multiple times around the outer periphery of the core shaft 9, and the intermediate joints 57 between adjacent strands of the coil body 53 are formed with an outer diameter smaller than the outer diameter of the coil body 53, thereby making the guidewire 50 even more flexible. This further improves the insertability of the guidewire 50 into the patient's body.

[0137] According to the guide wire 50 of this embodiment, the surface roughness of the coil body 53 is greater than the surface roughness of the core shaft 9. Therefore, even if a large force is applied to the guide wire 50 and the coil body 53 comes off the core shaft 9, the base end connecting portion 55 and the intermediate connecting portion 57 come off while connected to the coil body 53, and at least one of the base end connecting portion 55 itself and the intermediate connecting portion 57 itself can be prevented from being crushed and scattered.

[0138] Seventh Embodiment A seventh embodiment will be described.

[0139] The guidewire 60 of the seventh embodiment differs from the guidewire 50 of the sixth embodiment in the connection between the coil body and the proximal connecting portion and the connection between the coil body and the intermediate connecting portion. That is, the guidewire 50 of the sixth embodiment is configured such that the proximal connecting portion 55 and the intermediate connecting portion 57 are detached from the coil body 53 by making the surface roughness of the coil body greater than the surface roughness of the core shaft. The guidewire 60 of the present embodiment is configured such that the proximal connecting portion and the intermediate connecting portion are detached from the coil body by providing an oxide coating on the surface of the coil body and not providing an oxide coating on the surface of the core shaft.

[0140] FIG. 11 is a longitudinal cross-sectional view of the distal end of the guide wire of the seventh embodiment, and FIG. 12 is an enlarged view of part B in FIG.

[0141] The guide wire 60 of this embodiment includes a core shaft 9, a coil body 63 covering the tip of the core shaft 9, a tip connection portion 62 connected to the tip of the coil body 63 and the tip of the core shaft 9, a base end connection portion 65 connected to the base end of the coil body 63 and the core shaft 9, an intermediate connection portion 67 arranged between the tip connection portion 62 and the base end connection portion 65 in the longitudinal direction of the guide wire 60 and connected to the coil body 63 and the core shaft 9, and a coating agent 68 covering the outer periphery of the core shaft 9, the coil body 63, the tip connection portion 62, the base end connection portion 65, and the intermediate connection portion 67.

[0142] A gap 64 is formed between the core shaft 9 and the coil body 63 .

[0143] The coil body 63 is a hollow cylindrical coil body formed by winding one or more metal wires or resin wires. The coil body 63 is wound multiple times around the outer periphery of the core shaft 9. The tip of the coil body 63 is connected to the tip of the core shaft 9 by a tip connecting portion 62, and the base end of the coil body 63 is connected to the core shaft 9 by a base end connecting portion 65.

[0144] The wire material forming the coil body 63 can be the same as that of the coil body 3 of the first embodiment. In this embodiment, the wire material forming the coil body 63 is stainless steel. An oxide coating 63a is formed on the surface of the wire constituting the coil body 63, with oxygen bonding due to oxidation mainly with chromium in the stainless steel.

[0145] The tip connection part 62 joins the tip of the coil body 63 and the tip of the core shaft 9. The material of the tip connection part 62 can be the same as that of the tip connection part 2 of the first embodiment. In this embodiment, the material of the tip connection part 62 is a silver-tin brazing material.

[0146] The base end connecting portion 65 joins the base end of the coil body 63 to the core shaft 9. The outside diameter of the base end connecting portion 65 is smaller than the outside diameter of the coil body 63 between the wires that make up the coil body 63.

[0147] The base end connecting portion 65 can be made of the same material as the base end connecting portion 5 of the first embodiment. In this embodiment, the base end connecting portion 65 is made of an epoxy adhesive.

[0148] The intermediate connecting portion 67 is disposed between the distal connecting portion 62 and the proximal connecting portion 65 in the longitudinal direction of the guide wire 60, and connects the coil body 63 to the core shaft 9. The outer diameter of the intermediate connecting portion 67 is smaller than the outer diameter of the coil body 63 between the wires that make up the coil body 63.

[0149] The intermediate connector 67 may be made of the same material as the distal intermediate connector 7 a and the proximal intermediate connector 7 b of the second embodiment. In this embodiment, the intermediate connector 67 is made of an epoxy adhesive.

[0150] In this embodiment, there is one intermediate connecting portion 67. The number of intermediate connecting portions 67 is not limited to one, and may be two or more.

[0151] In this embodiment, the longitudinal width of the base end connecting portion 65 is formed across the two wires that make up the coil body 63, and there is one portion in the base end connecting portion 65 that has an outer diameter smaller than the outer diameter of the coil body 63. The longitudinal width of the base end connecting portion 65 may be formed across any number of wires of the coil body 63. The portion with an outer diameter smaller than the outer diameter of the coil body 63 may be formed in multiple locations in the base end connecting portion 65.

[0152] The longitudinal width of the intermediate connection part 67 is formed across the three wires that make up the coil body 63, and there are two portions in the intermediate connection part 67 that have an outer diameter smaller than the outer diameter of the coil body 63. The longitudinal width of the intermediate connection part 67 may be formed across any number of wires of the coil body 63. The portions with an outer diameter smaller than the outer diameter of the coil body 63 may be formed in one portion in the intermediate connection part 67, or in three or more portions.

[0153] The coating agent 68 covers the outer peripheries of the core shaft 9, the coil body 63, the distal connecting portion 62, the proximal connecting portion 65, and the intermediate connecting portion 67. The material of the coating agent 68 can be the same as the material of the coating agent 8 in the first embodiment. In this embodiment, the material of the coating agent 68 is polyacrylamide.

[0154] In the guide wire 60 described above, if the coil body 63 becomes detached from the core shaft 9 during the procedure, the wire constituting the coil body 63, which has an oxide coating 63a formed on its surface, causes the intermediate connecting portion 67 and the base end connecting portion 65 to become detached from the core shaft 9 together with the coil body 63, thereby preventing either the intermediate connecting portion 67 itself or the base end connecting portion 65 itself from being destroyed and leaking into the lumen of the patient's blood vessel, etc.

[0155] As in the guide wire 60 of this embodiment, the surface of the core shaft 9 on which no oxide coating is formed and the surface of the coil body 63 on which an oxide coating is formed are connected by an adhesive made of a resin material, which can be applied to a connection structure in which the surface of a first member on which no oxide coating is formed and the surface of a second member on which an oxide coating is formed are connected by an adhesive made of a resin material.

[0156] In this case, even if a large force is applied to the connection structure and the second member comes off from the first member, the adhesive comes off while still connected to the second member, preventing the adhesive itself from being crushed and scattered.

[0157] The guidewire 60 of this embodiment includes a core shaft 9, a coil body 63 covering the distal end of the core shaft 9, a distal connection portion 62 connecting the distal end of the coil body 63 to the distal end of the core shaft 9, and a proximal connection portion 65 connecting the proximal end of the coil body 63 to the core shaft 9, and the proximal connection portion 65 is made of an adhesive made of a resin material, which makes the guidewire 60 flexible. This improves the insertability of the guidewire 60 into the patient's body.

[0158] According to the guidewire 60 of this embodiment, an intermediate connecting portion 67 that connects the coil body 63 and the core shaft 9 is provided between the distal connecting portion 62 and the proximal connecting portion 65, and the intermediate connecting portion 67 is made of an adhesive made of a resin material, which makes the guidewire 60 flexible. This improves the insertability of the guidewire 60 into the patient's body.

[0159] According to the guidewire 60 of this embodiment, the coil body 63 is wound multiple times around the outer periphery of the core shaft 9, and the proximal end connection portion 65 is formed between adjacent strands of the coil body 63 at a position lower than the outer diameter of the coil body 63, thereby making the guidewire 60 even more flexible. This further improves the insertability of the guidewire 60 into the patient's body.

[0160] According to the guidewire 60 of this embodiment, the coil body 63 is wound multiple times around the outer periphery of the core shaft 9, and the intermediate joints 67 between adjacent strands of the coil body 63 are formed with an outer diameter smaller than the outer diameter of the coil body 63, thereby making the guidewire 60 even more flexible. This further improves the insertability of the guidewire 60 into the patient's body.

[0161] According to the guide wire 60 of this embodiment, an oxide coating 63a is formed on the surface of the coil body 63. Therefore, even if a large force is applied to the guide wire 60 and the coil body 63 comes off from the core shaft 9, the base end connecting portion 65 and the intermediate connecting portion 67 come off while still connected to the coil body 63, and at least one of the base end connecting portion 65 itself and the intermediate connecting portion 67 itself can be prevented from being crushed and scattered.

[0162] Eighth Embodiment An eighth embodiment of the present disclosure will be described.

[0163] The guidewire 70 of the eighth embodiment has an intermediate connecting portion and is different from the guidewire 1 of the first embodiment in the connection between the coil body and the proximal connecting portion and the connection between the coil body and the intermediate connecting portion. That is, the guidewire 70 of the eighth embodiment is configured such that the proximal connecting portion and the intermediate connecting portion can be detached from the coil body while still connected to it by forming a plurality of grooves on the surface of the coil body in a direction intersecting the longitudinal direction of the core shaft.

[0164] FIG. 13 is an enlarged view of the distal end of the guidewire according to the eighth embodiment.

[0165] The guide wire 70 of this embodiment includes a core shaft 9, a coil body 73 covering the tip of the core shaft 9, a tip connection portion 72 connected to the tip of the coil body 73 and the tip of the core shaft 9, a base end connection portion 75 connected to the base end of the coil body 73 and the core shaft 9, an intermediate connection portion 77 arranged between the tip connection portion 72 and the base end connection portion 75 in the longitudinal direction of the guide wire 70 and connected to the coil body 73 and the core shaft 9, and a coating agent 78 covering the outer periphery of the core shaft 9, the coil body 73, the tip connection portion 72, the base end connection portion 75, and the intermediate connection portion 77.

[0166] Inside the coil body 73 , a gap 74 is formed between the core shaft 9 and the coil body 73 .

[0167] The coil body 73 is a hollow cylindrical coil body formed by winding one or more metal wires or resin wires. The coil body 73 is wound multiple times around the outer periphery of the core shaft 9. The tip of the coil body 73 is connected to the tip of the core shaft 9 by a tip connecting portion 72, and the base end of the coil body 73 is connected to the core shaft 9 by a base end connecting portion 75.

[0168] The wire forming the coil body 73 can be made of the same material as the coil body 3 of the first embodiment. In this embodiment, the wire forming the coil body 73 is made of stainless steel. A plurality of grooves 73a are formed on the surface of the wire constituting the coil body 73 in a direction approximately perpendicular to the longitudinal direction of the core shaft 9. In Figure 13, the plurality of grooves 73a are indicated by vertically hatched stripes.

[0169] In this embodiment, a configuration will be described in which a plurality of grooves 73a are formed in a direction approximately perpendicular to the longitudinal direction of the core shaft 9 on the surface of the wire constituting the coil body 73. These grooves are not limited to those formed in a direction approximately perpendicular to the longitudinal direction of the core shaft, but may be any grooves formed in a direction intersecting the longitudinal direction of the core shaft on the surface of the wire constituting the coil body.

[0170] The tip connection part 72 joins the tip of the coil body 73 and the tip of the core shaft 9. The material of the tip connection part 72 can be the same as that of the tip connection part 2 of the first embodiment. In this embodiment, the material of the tip connection part 72 is a silver-tin brazing material.

[0171] The base end connecting portion 75 joins the base end of the coil body 73 to the core shaft 9. The base end connecting portion 75 can be made of the same material as the base end connecting portion 5 of the first embodiment. In this embodiment, the base end connecting portion 75 is made of an epoxy adhesive.

[0172] The intermediate connector 77 is disposed between the distal connector 72 and the proximal connector 75 in the longitudinal direction of the guidewire 70, and connects the coil body 73 to the core shaft 9. The material of the intermediate connector 77 can be the same as that of the distal intermediate connector 7a and the proximal intermediate connector 7b of the second embodiment. In this embodiment, the material of the intermediate connector 77 is an epoxy adhesive.

[0173] 13, in this embodiment as well, there is one intermediate connector 77. The number of intermediate connectors 77 is not limited to one, and may be two or more.

[0174] The longitudinal width of the base end connecting portion 75 may be formed across any number of wires of the coil body 73. The longitudinal width of the intermediate connecting portion 77 may be formed across any number of wires of the coil body 73.

[0175] The coating agent 78 covers the outer peripheries of the core shaft 9, the coil body 73, the distal connecting portion 72, the proximal connecting portion 75, and the intermediate connecting portion 77. The material of the coating agent 78 can be the same as the material of the coating agent 8 in the first embodiment. In this embodiment, the material of the coating agent 78 is polyacrylamide.

[0176] In the guide wire 70 described above, if the coil body 73 becomes detached from the core shaft 9 during the procedure, the coil body 73 is made of wire with multiple grooves 73a formed in a direction approximately perpendicular to the longitudinal direction of the core shaft 9, so that the intermediate connecting portion 77 and the base end connecting portion 75 will detach from the core shaft 9 together with the coil body 73, preventing at least one of the intermediate connecting portion 77 itself and the base end connecting portion 75 itself from being destroyed and leaking into the lumen of the patient's blood vessel, etc.

[0177] The guidewire 70 of this embodiment includes a core shaft 9, a coil body 73 covering the distal end of the core shaft 9, a distal connection portion 72 connecting the distal end of the coil body 73 to the distal end of the core shaft 9, and a proximal connection portion 75 connecting the proximal end of the coil body 73 to the core shaft 9. The proximal connection portion 75 is made of an adhesive made of a resin material, which makes the guidewire 70 flexible. This improves the insertability of the guidewire 70 into the patient's body.

[0178] According to the guidewire 70 of this embodiment, an intermediate connecting portion 77 that connects the coil body 73 and the core shaft 9 is provided between the distal connecting portion 72 and the proximal connecting portion 75, and the intermediate connecting portion 77 is made of an adhesive made of a resin material, which makes the guidewire 70 flexible. This improves the insertability of the guidewire 70 into the patient's body.

[0179] According to the guide wire 70 of this embodiment, a plurality of grooves 73a are formed on the surface of the coil body 73 in a direction intersecting the longitudinal direction of the core shaft 9. Therefore, even if a large force is applied to the guide wire 70 and the coil body 73 comes off from the core shaft 9, the base end connecting portion 75 and the intermediate connecting portion 77 come off while still connected to the coil body 73, and it is possible to prevent at least one of the base end connecting portion 75 itself and the intermediate connecting portion 77 itself from being crushed and scattered.

[0180] Ninth Embodiment A ninth embodiment of the present disclosure will be described.

[0181] The guidewire 70 of the ninth embodiment differs from the guidewire 30 of the fourth embodiment in the configuration of the core shaft. That is, the core shaft 81 of the ninth embodiment has a plurality of grooves 82 formed in a direction intersecting the longitudinal direction of the core shaft 81, and is configured so that the proximal connection portion and the intermediate connection portion can be detached from the coil body while connected thereto.

[0182] Fig. 14 is a partially enlarged view of the guide wire according to the ninth embodiment. Fig. 14 is an enlarged view of a portion of the guide wire according to the ninth embodiment that corresponds to the intermediate joint 37 of the guide wire 30 according to the fourth embodiment. Fig. 14 shows a cross section of the intermediate joint 37 and a side view of the core shaft 81.

[0183] The core shaft 81 has a plurality of grooves 82 in a direction intersecting the longitudinal direction of the core shaft 81. The grooves 82 may be provided over the entire core shaft 81, or may be provided only in the range connected to either the intermediate connecting portion 37 or the base end connecting portion 35.

[0184] According to the guide wire 80 of this embodiment, a plurality of grooves 82 are formed on the surface of the core shaft 81 in a direction intersecting the longitudinal direction of the core shaft 81. Therefore, even if a large force is applied to the guide wire 80 and the coil body 23 comes off the core shaft 81, the base end connecting portion 35 and the intermediate connecting portion 37 come off while connected to the coil body 23, and at least one of the base end connecting portion 35 itself and the intermediate connecting portion 37 itself can be prevented from being crushed and scattered.

[0185] Tenth Embodiment A tenth embodiment of the present disclosure will be described.

[0186] The guidewire 90 of the tenth embodiment differs from the guidewire 30 of the fourth embodiment in the configuration of the core shaft. That is, the core shaft 91 of the tenth embodiment has a plurality of grooves 92 formed along the longitudinal direction of the core shaft 91, and is configured so that the coil body 23 can be removed from the core shaft 91 with the proximal connection portion and the intermediate connection portion connected to the core shaft 91.

[0187] Fig. 15 is a partially enlarged view of the guide wire according to the tenth embodiment. Fig. 15 is an enlarged view of a portion of the guide wire according to the tenth embodiment that corresponds to the intermediate connector 37 of the guide wire 30 according to the fourth embodiment. Fig. 15 shows a cross section of the intermediate connector 37 and a side view of the core shaft 91.

[0188] The core shaft 91 has a plurality of grooves 92 along the longitudinal direction of the core shaft 91. The grooves 92 may be provided over the entire core shaft 91, or may be provided only in the range connected to either the intermediate connecting portion 37 or the base end connecting portion 35.

[0189] According to the guide wire 90 of this embodiment, a plurality of grooves 92 are formed on the surface of the core shaft 91 in a direction intersecting the longitudinal direction of the core shaft 91. Therefore, even if a large force is applied to the guide wire 90 and the coil body 23 comes off the core shaft 91, the base end connecting portion 35 and the intermediate connecting portion 37 remain connected to the core shaft 91, and at least one of the base end connecting portion 35 itself and the intermediate connecting portion 37 itself can be prevented from being crushed and scattered.

[0190] The guidewire according to several embodiments of the present disclosure has been described above. The present disclosure is not limited to the above embodiments, and various modifications can be made without departing from the spirit and scope of the present disclosure.

[0191] For example, the feature of coloring either the proximal connection portion or the intermediate connection portion, as in the guidewire 40 of the fifth embodiment, may be applied to the distal connection portion 2 and the proximal connection portion 5 of the guidewire 1 of the first embodiment, the distal connection portion 2, the distal intermediate connection portion 7a, the proximal intermediate connection portion 7b, and the proximal connection portion 5 of the guidewire 10 of the second embodiment, the distal connection portion 22 and the proximal connection portion 25 of the guidewire 20 of the third embodiment, the distal connection portion 22 of the guidewire 40 of the fifth embodiment, the distal connection portion 52, the intermediate connection portion 57, and the proximal connection portion 55 of the guidewire 50 of the sixth embodiment, the distal connection portion 62, the intermediate connection portion 67, and the proximal connection portion 65 of the guidewire 60 of the seventh embodiment, and the distal connection portion 72, the intermediate connection portion 77, and the proximal connection portion 75 of the guidewire 70 of the eighth embodiment.

[0192] In this case, the length of the tip connection portion, the length of the intermediate connection portion, and the length of the base connection portion can each be easily grasped, and the joining strength between each core shaft and coil body can be easily adjusted.

[0193] The feature of making the outer diameter of the intermediate connection portion and the base end connection portion smaller than the outer diameter of the coil body between the wires that make up the coil body may also be applied to the tip connection portion 72, intermediate connection portion 77 and base end connection portion 75 of the guide wire 70 of the eighth embodiment.

[0194] In this case, the guide wire 70 can be made even more flexible, which further improves the ease of inserting the guide wire 70 into the patient's body.

[0195] The guide wire 1 of the first embodiment, the guide wire 10 of the second embodiment, and the guide wire 20 of the third embodiment may be applied to the guide wire 1 of the first embodiment, the guide wire 10 of the second embodiment, and the guide wire 20 of the third embodiment, in which the surface roughness of the coil body is made larger than the surface roughness of the core shaft, in which an oxide coating is formed on the surface of the coil body but not on ... a plurality of grooves are formed on the surface of the coil body in a direction intersecting the longitudinal direction of the core shaft, in which the guide wire 70 of the eighth embodiment.

[0196] In this case, even if a large force is applied to the guide wire and the coil body comes off the core shaft, the base end connection portion and the intermediate connection portion will come off while still connected to the coil body, preventing at least one of the base end connection portion itself and the intermediate connection portion itself from shattering and flying away.

[0197] Like the guide wire 80 of the ninth embodiment, the fact that multiple grooves 82 are formed on the surface of the core shaft 81 in a direction intersecting the longitudinal direction of the core shaft 81 may also be applied to the core shafts of the guide wires of the first to third embodiments and the fifth to eighth embodiments.

[0198] In this case, even if a large force is applied to the guide wire and the coil body comes off the core shaft, the base end connection portion and the intermediate connection portion will come off while still connected to the coil body, preventing at least one of the base end connection portion itself and the intermediate connection portion itself from shattering and flying away.

[0199] The guide wire 90 of the tenth embodiment, in which a plurality of grooves 92 are formed on the surface of the core shaft 91 along the longitudinal direction of the core shaft 91, may be applied to the core shafts of the guide wires of the first to third and fifth embodiments.

[0200] In this case, even if a large force is applied to the guide wire and the coil body comes off the core shaft, the base end connection portion 35 and the intermediate connection portion 37 remain connected to the core shaft 91, preventing at least one of the base end connection portion 35 itself and the intermediate connection portion 37 itself from being crushed and scattered.

Claims

1. A guide wire (1, 10, 20, 30, 40, 50, 60, 70, 80, 90) comprising a core shaft (9, 81, 91), a coil body (3, 23, 53, 63) covering the tip of the core shaft, a tip connection part (2, 22, 52, 62, 72) connecting the tip of the coil body and the tip of the core shaft, and a base end connection part (5, 25, 35, 45, 55, 65, 75) connecting the base end of the coil body and the core shaft and including an adhesive made of a resin material.

2. The coil body (23, 53, 63) of the guide wire (20, 30, 40, 50, 60, 80, 90) according to claim 1 is wound around the outer periphery of the core shaft a plurality of times, and the base end connection part (25, 35, 45, 55, 65) is formed with an outer diameter smaller than the outer diameter of the coil body between adjacent strands of the coil body.

3. The base end connection part (45) of the guide wire (40) according to claim 1 or claim 2 is colored.

4. An intermediate connection part (7, 7a, 7b, 37, 47, 57, 67) for connecting the coil body and the core shaft is provided between the tip connection part and the base end connection part, and the intermediate connection part of the guide wire (30, 40, 50, 60) according to any one of claims 1 to 3 includes an adhesive made of a resin material.

5. The coil body (23) of the guide wire (30, 40, 50, 60) according to claim 4 is wound around the outer periphery of the core shaft a plurality of times, and the intermediate connection part (37, 47, 57, 67) is formed with an outer diameter smaller than the outer diameter of the coil body between adjacent strands of the coil body.

6. The intermediate connection part (47) of the guide wire (40) according to claim 4 or claim 5 is colored.

7. The surface roughness of the coil body (53) of the guide wire (50) according to any one of claims 1 to 6 is greater than the surface roughness of the core shaft (9).

8. An oxide film (63a) is formed on the surface of the coil body (63) of the guide wire (60) according to any one of claims 1 to 7.

9. A plurality of groove parts (73a) are formed on the surface of the coil body (73) of the guide wire (70) according to any one of claims 1 to 8 in a direction intersecting the longitudinal direction of the core shaft (9).

10. The guide wire (80) according to any one of claims 1 to 9, wherein a plurality of groove portions (82) are formed on the surface of the core shaft (81) in a direction intersecting the longitudinal direction of the core shaft (81).

11. The guide wire (90) according to any one of claims 1 to 9, wherein a plurality of groove portions (92) are formed on the surface of the core shaft (91) along the longitudinal direction of the core shaft (91).

12. A connection structure in which the surface of a first member (53) having a first surface roughness and the surface of a second member (9) having a second surface roughness greater than the first surface roughness are connected by an adhesive made of a resin material.

13. A connection structure in which the surface of a first member (9) on which an oxide film is not formed and the surface of a second member (63) on which an oxide film (63a) is formed are connected by an adhesive made of a resin material.

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