Portable liquid helium-free MRI-guided proton therapy system

A portable MRI-guided proton therapy system using high-temperature superconductors addresses the lack of real-time imaging in proton therapy, providing accurate tumor targeting and reducing healthy tissue risk through compact, cost-effective MRI integration.

WO2025155696A1 Publication Date: 2025-07-24OHIO STATE INNOVATION FOUND +1
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Patent Information

Application Number
PCT/US2025/011834
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-01-16
Filing Date
2025-01-16
Publication Date
2025-07-24

AI Technical Summary

Technical Problem

Current proton therapy systems lack accurate real-time imaging guidance, particularly for distinguishing tumors from healthy tissues, due to limitations in existing imaging technologies such as 2D orthogonal X-ray imaging, with MRI guidance not yet available for clinical use.

Method used

A portable MRI-guided proton therapy system utilizing high-temperature superconductors like magnesium diboride (MgB2) for the MRI assembly, eliminating the need for liquid helium cooling, allowing for compact, cost-effective, and real-time MRI imaging during proton therapy.

Benefits of technology

Enables accurate real-time imaging and treatment monitoring, enhancing tumor targeting and reducing risk to healthy tissues by leveraging MRI's soft tissue differentiation and functional imaging capabilities.

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Abstract

An example system for magnetic resonance imaging (MRI) guided proton therapy includes a source configured to generate and emit a heavy ion or proton beam; and an MRI assembly including at least one segmented coil magnet comprising a plurality of windings, where the plurality of windings of the at least one segmented coil magnet include a medium or high-temperature superconductor such that the at least one segmented coil magnet does not require a cryogenic liquid for cooling. An example magnet for MRI proton therapy includes field coils and shield coils arranged in Helmholtz coil pairs, where the field coils and the shield coils include a medium or high-temperature superconductor so the magnet does not require cryogenic liquid cooling, and where the field coils and the shield coils form a central opening through which a heavy ion or proton beam is directed during proton therapy.
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