Process for the preparation of deucravacitinib and intermediates thereof and method for purifying deucravacitinib
WO2025186427A8PCT designated stage Publication Date: 2025-10-02CURIA SPAIN SAU
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Patent Information
- Application Number
- PCT/EP2025/056245
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-03-08
- Filing Date
- 2025-03-07
- Publication Date
- 2025-10-02
AI Technical Summary
Technical Problem
Existing methods for preparing Deucravacitinib and its intermediates yield low quantities, and purification methods result in high residual solvent content unsuitable for pharmaceutical use.
Method used
A process involving the hydrolysis of an ester to a carboxylic acid followed by direct amidation with an amine in the presence of T3P and a tertiary amine, and a purification method using dichloromethane and methanol distillation to achieve acceptable residual solvent levels.
Benefits of technology
The process achieves high yields of Deucravacitinib intermediates and purifies the compound to meet pharmaceutical standards, suitable for industrial-scale production.
✦ Generated by Eureka AI based on patent content.
Smart Images
Figure EP2025056245_02102025_PF_FP_ABST
Abstract
The present application discloses a process to prepare an compound of formula (I), which is an intermediate to produce Deucravacitinib. The application also relates to a crystallization method to purify Deucravacitinib.
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