MRNAs DIFFERENTIALLY EXPRESSED IN CANCER

Abstract

Provided is a method of determining whether a patient has cancer. Also provided is a method of determining effectiveness of a treatment of a patient for cancer. Additionally provided is a method for isolating RNA from a swab sample. Further provided is an exosome comprising at least one siRNA targeting a gene. Also provided is a method of treating cancer using the exosome.

Description

[0001] mRNAs DIFFERENTIALLY EXPRESSED IN CANCER CROSS-REFERENCE TO RELATED APPLICATIONS This application claims the benefit of (a) U.S. Provisional Application No.63 / 560965, filed March 4, 2024; (b) U.S. Provisional Application No. 63 / 682926, filed August 14, 2024; (c) U.S. Provisional Application No. 63 / 689422, filed August 20, 2024; and (d) U.S. Provisional Application No. 63 / 719157, filed October 22, 2024, all of which are incorporated by reference herein in their entirety. BACKGROUND OF THE INVENTION (1) Field of the Invention The present invention generally relates to the use of mRNA genetic transcripts to (a) identify and differentiate between cancers, and (b) determine the effectiveness of a treatment for a cancer. Also provided is methods for isolating RNA from a buccal swab sample. Further provided is an exosome comprising at least one siRNA targeting a gene. Also provided is a method of treating cancer using the exosome. (2) Description of the related art Frequency of genomic, transcriptomic, and proteomic alterations are hallmarks of inflammatory- related disorders, such as cancers. “The hallmarks of cancer constitute an organizing principle for rationalizing the complexities of neoplastic disease. Nowadays, there are ten biological capabilities acquired during the multistep development of human tumors: (1) sustaining proliferative signaling, (2) evading growth suppressors, (3) resisting cell death, (4) enabling replicative immortality, (5) inducing angiogenesis, (6) activating invasion and metastasis, (7) genome instability, (8) inflammation, (9) reprogramming of energy metabolism, and (10) evading immune destruction.” (Hanahan & Weinberg, 2011). These genomic, transcriptomic and proteomic alterations could represent a deregulated interaction leaning to development of tumor and / or tumor progression. It is interesting to note that the identified proteins were highly expressed only in solid tumors, as cancer cells must use them to modify the tissue microenvironment and induce immune self-regulation (López-Cortés et al., 2021). Cancer can be considered a silent disorder in which the patient experiences no obvious symptoms. Dr. Dvorak coined the phrase that cancer was “a wound that does not heal,” implying that the cellular and biochemical processes associated with wound healing are similar to those involved in the growth and development of the tumor itself (Dvorak, 1986). The word inflammation is derived from the Latin inflammare, which means to ignite or set a fire. Inflammation is a complex cascade type reaction which involves serum components such as red blood cells, platelets, proteins, and many other tissue factors such as thromboplastin. This cascade phenomenon is activated by inflammatory cytokines which are directly related to transcriptomic levels of mRNA. There is an active proliferation phase that is characterized by massive and extensive phenotypically programming of many of the cellular components involved in the inflammatory process. This reprogramming is altered and / or exaggerated as the tumor develops changes that ultimately promote cancer progression and spread. As an example, monocytes are recruited to the wound and these monocytes quickly differentiate into macrophages and in many cases this is one of the most highly represented cell types in the healing wound and the tumor stroma (Mantovani, 2009). In the case of breast cancer, tumor associated macrophages (TAMs)comprise as much of 50% of the tumor mass (Solinas et al., 2009). This complex reprogramming is generated and stimulated by inflammatory cytokines such as IL12, IL23 and NF-κB (Sica et al., 2008). Cytokine signaling directs changes in the associated cells that are involved in the wound as well as the cancer. Cytokine signaling is an important part of human body regulation. Most cytokines have cell secreted proteins from glyocells in the nervous system and are necessary for intracellular signaling. Most cytokines are local regulators that alert and activate lymphocytes. Three criteria are required for the immunologic destruction of established tumors: (i) sufficient numbers of immune cells with highly avid recognition of tumor antigens must be generated in vivo (ii) these cells must traffic to and infiltrate the tumor stroma, and (iii) the immune cells must be activated at the tumor site to manifest appropriate effector mechanisms such as direct lysis or cytokine secretion capable of causing tumor destruction (Rosenberg et al., 2004). The role of mRNA is to carry protein information from the DNA and a cell’s nucleus to the cell’s cytoplasm. In the cytoplasm, protein making machinery reads the mRNA sequence and translates each three-base codon into its corresponding amino acid and a growing protein chain. The expression of cytokines and pro-inflammatory factors including many of the interleukins are highly regulated at many levels, including gene transcription, messenger ribonucleic acid (mRNA) translation, and mRNA degradation (Stoecklin et al., 2006). Furthermore, mRNA stability could be determined by several factors; (1) by a balance between its rates of synthesis and degradation. (2) alterations in response to numerous environmental stimuli including carbon source, viral infection, and developmental transitions, allowing for rapid alterations in gene expression; (3) a specialized system of mRNA degradation functions to eliminate potentially deleterious errors in mRNA synthesis; (4) efficient mRNA degradation is required for cell growth in both prokaryotes and eukaryotes, emphasizing the importance of this process (Maloy & Hughes, 2013). Regarding its structure, mRNAs have three parts: Nucleotides at the 5′ end provide binding sites for proteins that initiate polypeptide synthesis, nucleotides in the middle specify the sequence of amino acids in the polypeptide, and nucleotides at the 3′ end regulate the stability of the mRNA. Within the protein- coding region, successive triplets of three nucleotides (i.e. codons), specify the sequence of amino acids. It is considered that the genetic code relating nucleotide triplets to amino acids is, with a few minor exceptions, universal, and one to six different triplet codons encode each amino acid. An initiation codon (AUG) specifies methionine, which begins all polypeptide chains, but may subsequently be removed. In addition, any one of three termination codons (UAA, UGA, UAG) stops peptide synthesis (Fermín et al., 2020). Thus, there is a complex association and / or relationship between RNA and RNA binding proteins (RBPs), cytokine mRNAs and microRNAs (miRNAs). The post transcriptional regulation of cytokines expression is most important with respect to cancer development and progression. “During the wound healing process and the evolution of the reactive tumor stroma, each of the cellular constituents responds to specific environmental clues to undergo significant stable, yet reversible, acquisition or loss of specific cellular features that can be inherited by subsequent cellular generations in the absence of alterations in DNA sequence” (Byun & Gardner, 2013). Epigenetic regulation through mRNA is an important mode of cellular control during the wound healing response in the development of cancer. This process of wound healing as well as cancer development is a complex phenomenon that involves growth factors, cytokines and extracellular enzymes that shape the environment in the tissue as well as around the cancer. mRNA represents an emerging genomic science and technology that has led to the development of vaccines against coronavirus and the treatment of cancer. mRNA can also be used to evaluate the expression of inflammatory proteins, called cytokines and chemokines, that are involved in immune system regulation, tissue damage and repair, genetic disorders, and it can also be applied to immunotherapy through the expression of antigens, antibodies or receptors. mRNA is the only coding RNA in organisms and is the 'middleman' of gene expression. Genetic information in DNA is communicated by mRNA to protein manufacture machinery, along with regulatory systems for protein expression and translation. In cancer evaluation and treatment, mRNA can be used as a biomarker and a target for cancer therapy, and the mRNA responsible for encoding tumor antibodies also has the potential to evoke effective anti-tumor immunity (Obeng et al. 2019). At present, mRNA plays an increasingly important role in the occurrence and development of tumors, treatment and diagnosis. In recent years, mRNA tumor vaccines have been gradually applied to cancer treatment. In addition, mRNA therapy has also been beginning to play a role in the treatment of various types of tumors as an emerging gene therapy (Coelho et al. 2017.; Zheng et al. 2021). Although cancer cells produce a variety of chemokine ligands (chemical messengers) that may be involved in neoangiogenesis, attraction and retention of inflammatory cells, and tumor cell proliferation, neoplastic cells express a limited repertoire of chemokine receptors. These receptors play distinct roles in distant organ metastasis (Muller et al., 2001; Murakami et al., 2003). Chemokine receptors can play a critical role in tumor progression apart from their ability to affect organ-selective metastasis. Murakami and coworkers (2003) demonstrated in vivo chemokine receptor-mediator immune evasion by tumor cells in skin cancer, such as melanoma. CCL27 (also called ESkine, ALP, ILC, or CTACK) appears to have effects on tumor cells implanted into the dermis because of it’s ability to cross the basement membrane after synthesis by keratinocytes. They elegantly discuss how the presence of CCL27 in the skin could potentially explain why CCR10, chemokine receptor expression, could be advantageous to melanoma. This group’s results demonstrate that chemokine receptors may play critical roles in tumor progression apart from their ability to affect organ-selective metastasis. They predicted that inhibition of the CCL27-CCR10 pathway should make CCR10-B16 cells more susceptible to the host anti-tumor response. They state: “Indeed, CCR10-B16 tumor formation was markedly reduced by treatment with neutralizing antibodies to CCL27.” These findings by Murakami and coworkers (2003), underscores the use of exosomes, 100 nm sized vesicles, which have the capability to deliver a wide range of therapeutics including genetic material into the cells inflicted with cancer. The application of exosomes containing genetic nucleotides, such as mRNA, may represent a major breakthrough in the treatment of malignant melanoma, a potentially fatal skin cancer that is increasing in incidence (Dreiling, et.al., 1996). Skin cutaneous melanoma (SKCM) is one of the most aggressive and life- threatening cancers with high incidence rate, metastasis rate and mortality. Early detection and stratification of risk assessment are essential to treat SKCM and to improve survival rate (Ma et.al., 2022). The ability of skin cancer cells to avoid immune surveillance may be central to the progression and metastasis of melanoma cells. KRT1 / 2 / 5 / 6 / 8 / 10 / 14 / 15 / 16 / 17 expression is elevated in primary melanoma compared with metastatic, and that high KRT1 / 5 / 6 / 14 / 15 / 16 / 17 mRNA levels predict poor prognosis. These findings not only shed light on the molecular alterations in SKCM but also provide the foundation for further research in this area (Han, et.al., 2021). Bladder cancer Bladder cancer (BC) is the tenth most predominant cancer worldwide, with an estimated 549,000 new cases and 200,000 deaths in 2018 (Bray et al., 2018). Approximately 75% of bladder cancer patients present with the disease confined to the inner lining of the bladder the mucosa or submucosa, termed non- muscle invasive bladder cancer (NMIBC)(Cambier et.al, 2016). Intravesical administration of Mycobacterium Bovis bacillus Calmette- Guerin (BCG) is the gold- standard treatment for high risk NMIBC and is also recommended for intermediate-risk following a transurethral resection of bladder tumors (Babjuk et.al., 2019). BCG has been used for the treatment of bladder cancer since 1976 and continues to be at the forefront of therapeutic options for this malignancy. Despite its success and worldwide acceptance, the antitumor effector mechanisms remain elusive. (Morales et.al., 1976). With respect to cytokine expression, TNF- related apoptosis-inducing ligand (TRAIL) is induced by BCG treatment, and TRAIL was expressed on polymorphonuclear neutrophils (PMN) in the urine obtained from patients after intravesical BCG instillation (Ludwig, 2004). Despite success of BCG treatment, from 30% to 40% of the cases are faced with disease recurrence following BCG immunotherapy (Kamat et.al., 2018). The key is the ability to have simple reliable criteria for prediction of the presence of NMIBC as well as BCG response. Cytokines and chemokines are associated with the development and progression of cancer. Oxidative stress and reactive oxygen species are involved in the formation, development, and progression of bladder cancer (Phaniendra, 2015). Reactive oxygen / nitrogen species (ROS / RNS) are involved in the development of various kinds of cancer due to irreversible damage to cellular and extracellular macromolecules, including DNA and associated mutations (Islam, 2019). An analysis of the plasma levels of protein carbonyls, thiol groups, -3 nitrotyrosine, lipid peroxidation, as well as non- enzymatic plasma antioxidant capacity using DPPH and ABTS+ radicals, confirmed that all analyzed biomarkers are higher in enrolled BC patients than in healthy subjects. A positive correlation between the degree of bladder cancer progression and the level of oxidative stress was also found (Wigner, 2021). BC patients in another study showed increased concentrations of markers characterizing oxidative stress and the inflammatory response, such as MDA, AOPP, and CRP as well as markers of angiogenesis, such as ANG, combined with the decreased activity of endogenous antioxidants (Sawicka, 2020). The majority of the newly diagnosed cases of BC are diagnosed prior to muscle invasion, thus potentially completely curable. Unfortunately, >20% of patients initially diagnosed with non-muscle-invasive bladder cancer will eventually die of their disease despite local endoscopic surgery (Utz, 1980). Levels of mRNA transcript CCL27 can be a practical and reproducible biomarker to predict the presence of non-invasive muscle cancer as well as the outcome of BCG in these patients (Chong and Wang, 2020). There is also a potential role of CCL27 in the recruitment of T-cells (Tregs) to TME (tumor microenvironment), thereby reducing the disease recurrence survival following BCG therapy (Martinez et.al, 2019). Additionally, serum CCL27 predicts the response to BCG immunotherapy in NMIBC (Zhong et al.2020). CD4+ regulatory T cells (Tregs) expressing the transcription factor FoxP3 are highly immune suppressive and play central roles in the maintenance of self-tolerance and immune homeostasis, yet in malignant tumors they promote tumor progression by suppressing effective antitumor immunity. also identified There is also a potential role of CCL27 in the recruitment of Tregs to TME, thereby reducing the disease recurrence survival following BCG therapy (Zhong 2020). Colorectal cancer Colorectal cancer (CRC) is the second leading cause of cancer-related deaths worldwide. In 2020, more than 1.9 million new cases of colorectal cancer and more than 930,000 deaths due to colorectal cancer were estimated to have occurred worldwide (WHO, 2023). No single predominant risk factor attributes to CRC, but family history of CRC, smoking, excessive alcohol consumption, high intake of red and processed meat, obesity, physical inactivity and diabetes have been identified as risk factors, apart from age and male sex, in epidemiologic studies. Inflammatory bowel disease, such as ulcerative colitis and Crohn's disease, is a risk factor for CRC, suggesting link of chronic inflammation with malignant disease. This is also supported by lowered risk associated with regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs), seen in observational studies and randomized clinical trials, and in studies reporting that polymorphisms in inflammation genes are associated with CRC risk (Song L et al., 2018). Chemokines are significantly associated with CRC risk. As previously mentioned, chemokines are potent attractants for white blood cells to sites of injury or infection, acting as acute and chronic inflammation mediators. Regarding carcinogenesis, “chemokines may recruit tumor-associated leukocytes which induce angiogenesis and control tumor cell invasion, or directly induce migration of epithelial / endothelial cells that express their receptors." (Song L, et al.2018). The following mRNA genes are relevant with colorectal cancer: KRT1: Keratin 1 maintains the intestinal barrier by upregulating tight junction proteins in ulcerative colitis (Wu et al. 2021). "KRT1 was presumed to play some roles in maintaining intestinal epithelium barrier and the progression of inflammatory bowel disease (IBD). In this study, we found that the expression of KRTI was detected in intestinal tissue and its down-regulation was associated with the progression of IBD. In addition, KRT1 played an important role in maintaining epithelial barrier during a challenge of interleukin 1-beta (IL-1ß)." (Dong, X. et al.2017). CASP3: Caspase 3, 8 and 9 are important molecules in apoptotic (programmed cell death) pathways which play key roles in cancer development and progression. (Bodmer et al. 1994). Because of the important functions of caspase proteins in cancers, expression levels of them in CRC tissues were evaluated and compared with normal marginal tissues. The objective of this study was also to reveal if there was any relation between mRNA expression level of these molecules and patients’ clinical features. Breast cancer Worldwide, breast cancer is a leading type of cancer in women, accounting for 25% of all cases. It is more common in developed countries and is more than 100 times more common in women than in men. What is very important to realize is that in most people who develop breast cancer have no symptoms at the time of diagnosis; the tumor is detected by breast cancer screening test (Hayes & Lippman, 2022). The patients that do have symptoms usually notice a lump that feels different from the rest of the breast tissue. The exact developmental process in breast cancer is fairly unknown and several hypotheses have emerged. One significant hypothesis involves inflammation and that inflammation initiates promotion of tumors, angiogenesis and metastasis (Grivennikov et al., 2010). Inflammation in a tumor microenvironment involves infiltrating immune cells and activated fibroblasts. These cells secrete cytokines, chemokines and growth factors to which the tumor responds (Coussens, 2002; Grivennikov et al., 2010). Cytokines that regulate inflammatory breast cancer microenvironment include interleukin (IL)-1, IL-6, IL-11, and transforming growth factor-β (TGF-β). These cytokines stimulate cancer cell proliferation and invasion (Nicolini et al., 2006). Also, cytokine receptor activation and intracellular signaling by NF-κB accelerate tumor progression (Karin and Greten 2005; Hsing et al., 2012). TGF-β is the most extensively studied cytokine in breast cancer. This cytokine has dual functions in tumor progression. As a tumor suppressor, it has antiproliferative effects in the early stages of tumorigenesis, but tumor cells in later stages evade this effect and progress in response to TGF-β (Joshi and Cao 2010; Band and Laiho 2011; Zu et al., 2012). Angiogenesis or growth of blood vessels into the area of the tumor is essential for tumor growth progression. Many cytokines participate in angiogenesis. In particular, TGF-β enhances vascularity by regulating factors that increase angiogenesis (Wilson and others 2010). Chronic inflammation can also lead to angiogenesis, because tumor-infiltrating lymphocytes secrete copious amounts of proinflammatory cytokines, such as IL-6, IL-1a, IL-1b, tumor necrosis factor-α, and oncostatin M (Angelo & Kurzrock, 2007). The important point to consider in this discussion is that the levels of cytokines have an effect on tumor progression and have been correlated with tumor stage, survival, and malignancy. Thus showing these cytokines as potential prognostic factors. Specifically, high levels of TGF-β have been linked to worse survival in breast cancer patients, and plasma TGF-β levels might be predictive of local and distant metastasis (Grau et al., 2008; Zu et al., 2012). In other important findings, serum IL-6 levels are significantly higher in breast cancer patients than in healthy women, and increased IL-6 levels correlate with poorer survival and diminished response to endocrine therapy in patients with metastatic breast cancer (Zhang & Adachi 1999; Frasor 2012). Responses to chemotherapy and hormone therapy are also associated with different levels of cytokines. Many, if not most, of the inflammatory-associated diseases (e.g., colorectal cancer, breast cancer, and bladder cancer) manifest as silent disorders before diagnosable symptoms are apparent to the patient or their doctor. Early identification of these silent inflammatory reactions and / or disorders underlying the occurrence of disease are elusive and not readily apparent. Biomarkers The fact that development of better evaluation tools and biomarkers was named a top priority of the FDA' s Critical Path Opportunities Report in 2006 underlined the importance of defining biomarkers validation and qualification processes (FDA Critical path opportunities report, 2006). On average, around 65% of drug approvals by EMA and FDA between 2015 and 2019 have been associated with incorporation of at least 1 biomarker in the development program and higher percentage of biomarker acceptance is expected in the near future (Gromova et al., 2020). mRNA transcripts are becoming very important as molecular biomarkers for the diagnosis and treatment of many diseases, cancer being very important. The mRNA transcript carries the gene's protein information encoded in DNA. The mRNA moves from the cell nucleus to the cell cytoplasm where it is used for synthesizing the encoded protein. These biomarkers offer early and more accurate prediction and diagnosis of disease and disease progression, and the ability to identify individuals at risk. Biomarkers are identified herewith that distinguishes between various diseases including colorectal cancer, breast cancer and bladder cancer. These biomarkers can also be used to determine the effectiveness of a treatment for these diseases. BRIEF SUMMARY OF THE INVENTION Provided is a method of determining whether a patient has bladder cancer, colon cancer, or breast cancer. The method comprises a) measuring an mRNA level of at least one gene in a tissue of the patient, wherein the at least one gene is CCL27, KRT1, NR3C1, CASP3, STK11, GCKR, SLC6A3, NFKB1, EDAR, GH1, IL1A, SIRT1, PPARG, CRHR1 or any combination thereof; b) comparing the mRNA levels determined in a) with an mRNA level of the at least one gene from a reference tissue from i) a subject not diagnosed with cancer; and ii) at least one subject with bladder cancer, and / or iii) at least one subject with colorectal cancer, and / or iv) at least one subject with breast cancer, wherein A) the patient has bladder cancer if the mRNA level(s) determined in a) is different than the mRNA levels determined in b)i) and is similar to the mRNA level from b)ii); the patient has colorectal cancer if the mRNA level(s) determined in a) is different than the mRNA levels determined in b)i) and is similar to the mRNA level from b)iii); and the patient has breast cancer if the mRNA level(s) determined in a) is different than the mRNA levels determined in b)i) and is similar to the mRNA level from b)iv). Also provided is a method of determining whether a patient has a cancer. The method comprises a) measuring mRNA levels of (i) IL10, KRT1, MMP13, NFKB2, and STK11, and / or (ii) CCL27, KRT1, NR3C1, CASP3, and CRHR1 in a tissue of the patient; and b) comparing the mRNA levels determined in a) with (A) the mRNA levels of (i) and / or (ii) from a tissue from a subject not diagnosed with cancer and b) and (B) the mRNA levels of (i) and / or (ii) from tissue from a subject diagnosed with cancer; wherein the patient has cancer if the mRNA levels determined in a) is different than the mRNA levels determined in (A) and not different from the mRNA levels determined in (B), and the patient does not have cancer if the mRNA levels determined in a) is not different than the mRNA levels determined in (A) and different from the mRNA levels determined in (B). Additionally provided is a method of determining whether a patient has breast cancer. The method comprises a) measuring mRNA levels of any combination of (i) 5 genes listed in Table 9, or (ii) 6 genes listed in Table 10, in a tissue of the patient; and b) comparing the mRNA levels determined in a) with (A) the mRNA levels of the combination of 5 or 6 genes from a tissue from a subject not diagnosed with breast cancer and (B) the mRNA levels of the combination of 5 or 6 genes from tissue from a subject diagnosed with breast cancer; wherein the patient has breast cancer if the mRNA levels determined in a) is different than the mRNA levels determined in (A) and not different from the mRNA levels determined in (B), and the patient does not have breast cancer if the mRNA levels determined in a) is not different than the mRNA levels determined in (A) and different from the mRNA levels determined in (B). Also provided is a method of determining effectiveness of a treatment of a patient for bladder, breast or colorectal cancer. The method comprises measuring a first mRNA level of at least one gene in a tissue of the patient before the treatment, wherein the at least one gene is CCL27, KRT1, NR3C1, CASP3, STK11, GCKR, SLC6A3, NFKB1, EDAR, GH1, IL1A, SIRT1, PPARG, CRHR1 or any combination thereof; treating the patient with the treatment; and measuring a second mRNA level of the at least one gene in the tissue of the patient after the treatment; comparing the first mRNA level with the second mRNA level, wherein if the first mRNA level is lower than the second mRNA level with any of the genes except IL1A and / or EDAR, and / or if the first mRNA level of IL1A and / or EDAR is greater than the second mRNA level, then the treatment is effective, and if the first mRNA level is not lower than the second mRNA level with any of the genes except IL1A and / or EDAR, and / or if the first mRNA level of IL1A and / or EDAR is not greater than the second mRNA level, then the treatment is not effective. Further provided is a method of determining effectiveness of a treatment of a patient for cancer. The method comprises measuring first mRNA levels of (i) IL10, KRT1, MMP13, NFKB2, and STK11 and / or (ii) CCL27, KRT1, NR3C1, CASP3, and CRHR1 in a tissue of the patient before the treatment; treating the patient with the treatment; and measuring second mRNA levels of (i) and / or (ii) in the tissue of the patient after the treatment; comparing the first mRNA levels with the second mRNA levels, wherein if the second mRNA levels are more similar to mRNA levels of (i) and / or (ii) in the tissue of an individual without cancer than the mRNA levels before treatment, then the treatment is effective, or if the second mRNA level are not more similar to mRNA levels of (i) and / or (ii) in the tissue of an individual without cancer than the mRNA levels before treatment, then the treatment is not effective Also provided is a method of determining effectiveness of a treatment of a patient for breast cancer. The method comprises measuring first mRNA levels of any combination of (a) 5 genes listed in Table 9 or (b) 6 genes listed in Table 10, in a tissue of the patient before the treatment; treating the patient with the treatment; measuring second mRNA levels in the tissue of the patient after the treatment; and comparing the first mRNA levels with the second mRNA levels, wherein if the second mRNA levels are more similar to mRNA levels of the 5 or 6 genes in the tissue of an individual without breast cancer than the mRNA levels before treatment, then the treatment is effective, or if the second mRNA levels are not more similar to mRNA levels in the tissue of the individual without cancer than the mRNA levels before treatment, then the treatment is not effective. Additionally provided is a method for isolating RNA from a swab sample. The method comprises obtaining the swab sample, storing the swab sample for more than two weeks and up to two years at any temperature between room temperature and -80 C inclusive, then isolating the RNA from the swab sample. Further provided is an exosome comprising at least one siRNA targeting a gene wherein the gene is CCL27, KRT1, NR3C1, CASP3, STK11, GCKR, SLC6A3, NFKB1, EDAR, GH1, IL1A, SIRT1, PPARG, CRHR1 or any combination thereof. Additionally provided is an exosome comprising at least one mRNA of a gene, wherein the gene is IL1A, EDAR or the combination thereof. Also provided is an exosome comprising at least five siRNAs each targeting a gene, wherein the targeted genes are any combination of (a) 5 genes listed in Table 9 or (b) 6 genes listed in Table 10. Further provided is a method of treating colorectal cancer, breast cancer, bladder cancer, endometriosis, or skin cancer in a patient. The method comprises administering an exosome to the patient. BRIEF DESCRIPTION OF THE SEVERAL VIEWS OF THE DRAWINGS FIG.1 is a graph showing total RNA isolation from buccal swabs using various makes of swabs. FIG.2 is a graph showing the RNA concentration of COPAN buccal swabs from 34 bladder cancer patients. FIG.3 is a graph showing the RNA concentration of COPAN buccal swabs from 27 breast cancer patients. FIG.4 is a graph showing the RNA concentration of COPAN buccal swabs from 24 colorectal cancer patients. FIG.5 is a graph showing RNA concentration of COPAN buccal swabs from 75 control individuals. DETAILED DESCRIPTION OF THE INVENTION Definitions ● Angiogenesis: The physiological process through which new blood vessels form from pre-existing vessels, formed in the earlier stage of vasculogenesis. ● Apoptosis: the death of cells which occurs as a normal and controlled part of an organism's growth or development. ● Cancer: A disease caused by an uncontrolled division of abnormal cells in a part of the body. ● Cascade reaction: A chemical process that integrates at least two reactions, of which each subsequent reaction can only start when the previous reaction step is completed (also called tandem or domino reaction). ● Chemokines: Any of a class of cytokines with functions that include attracting white blood cells to sites of infection. ● CCL27: alternative gene names : CCL27; CTAK;CTAk; PESKY. ● Colorectal cancer (also colon cancer herein): Cancer that forms in the tissues of the colon and rectum. Most colorectal cancers are adenocarcinomas (cancers that begin in cells that make and release mucus and other fluids). ● Cytokines: Small proteins that are involved in signals sent between cells (e.g. nuclear factorE2 (Nrf2), superoxide dismutase (SOD), TNF-a and NF-kB, IFN-30Y, and IL-6). ● DNA: Deoxyribonucleic acid, a self-replicating material which is present in nearly all living organisms as the main constituent of chromosomes. It is the carrier of genetic information. ● DNA Molecule: One end of the DNA molecule is known as 5′ (five prime), and the other end is known as 3′. (three prime). The numbers 3′ and 5′ refer to the number of carbon atoms in a deoxyribose sugar molecule that a phosphate group binds to. The carbons in sugar are numbered clockwise, beginning with the oxygen atom. ● Epigenome: Consists of chemical compounds that modify, or mark, the genome in a way that tells it what to do. Different cells have different epigenetic marks. ● Homeostasis: is the state of steady internal, physical, chemical, and social conditions maintained by living systems. This is the condition of optimal functioning for the organism. ● Genetic reprogramming: A technique that involves dedifferentiation of adult somatic cells to produce patient-specific pluripotent stem cells. ● Genomic alterations: Any change in the DNA sequence can alter the genetic code and therefore may alter the synthesis of the protein that it encodes. The heterogeneity and homogeneity of genomic alterations during metastasis is important to provide a basis for cancer metastasis. ● Immune cells: Cells that are part of the immune system and help the body fight infections and other diseases. Immune cells develop from stem cells in the bone marrow and become different types of white blood cells. ● Innate immunity: A person's physical, chemical, and cellular defenses against invasion or disease. ● Inflammatory disorders: Where the immune system causes inflammation by mistakenly attacking the body's own cells or tissues. There are a number of ways that our immune system can go wrong and cause inflammation. ● Inflammatory molecules: Inflammatory mediators that are part of the complex biological response of body tissues to harmful agents, such as bacteria, viruses, damaged cells or toxic irritants. ● Interleukins: A type of cytokine first thought to be expressed by leukocytes alone but have later been found to be produced by many other body cells. They play essential roles in the activation and differentiation of immune cells, as well as proliferation, maturation, migration, and adhesion. ● Ligands: Chemical messenger released by one cell to signal itself or a different cell. ● Lymphocytes: A type of white blood cell that is part of the immune system and they help fight disease and infection in the body. ● Macrophages: A type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells. ● Monocytes: A type of white blood cell (leukocytes) that reside in your blood and tissues to find and destroy germs (viruses, bacteria, fungi and protozoa) and eliminate infected cells. Monocytes call on other white blood cells to help treat injury and prevent infection. ● mRNA: Messenger RNA. Transfers information from DNA to the cell machinery that makes proteins. ● miRNA: Small, non-coding RNA molecules that regulate expression of a person's genes. ● Neoplasm: An abnormal mass of tissue that forms when cells grow and divide more than they should or do not die when they should. Neoplasms may be benign (not cancer) or malignant (cancer). Benign neoplasms may grow large but do not spread into, or invade, nearby tissues or other parts of the body. ● Nucleotides: the basic building block of nucleic acids (RNA and DNA). A nucleotide consists of a sugar molecule (either ribose in RNA or deoxyribose in DNA) attached to a phosphate group and a nitrogen-containing base. The bases used in DNA are adenine (A), cytosine (C), guanine (G) and thymine (T). ● Proteins: Any of a class of nitrogenous organic compounds that consist of large molecules composed of one or more long chains of amino acids and are an essential part of all living organisms, especially as structural components of body tissues such as muscle, hair, collagen, etc., and as enzymes and antibodies. ● Proteomic alterations: Modifications of the entire set of proteins produced or modified by an organism or system. ● Three-base codon: A DNA or RNA sequence of three nucleotides (a trinucleotide) that forms a unit of genomic information encoding a particular amino acid or signaling the termination of protein synthesis (stop signals). ● Thromboplastin: A complex enzyme that is found in brain, lung, and other tissues and especially in blood platelets and that functions in the conversion of prothrombin to thrombin in the clotting of blood. ● Transcriptomic alterations: A set of biological processes common to most eukaryotic cells by which an RNA primary transcript is chemically altered following transcription from a gene to produce a mature, functional RNA molecule that can then leave the nucleus and perform any of a variety of different functions in the cell. ● Transcription factors: Proteins that help turn specific genes "on" or "off". ● Tumor: A swelling of a part of the body, generally without inflammation, caused by an abnormal growth of tissue, whether benign or malignant. ● Tumor stroma: A type of white blood cell that surrounds and kills microorganisms, removes dead cells, and stimulates the action of other immune system cells. It plays a causative role during initiation, progression, and metastasis of cancer development. ● Stem cells: Stem cells are special human cells that can develop into many different cell types, from muscle cells to brain cells. In some cases, they also can repair damaged tissues. Buccal cells as sources of mRNA We describe a method to use buccal or cheek cells as tissue from which to isolate sufficient nanogram amounts of mRNA that can be measured in microarray chips. Buccal cells are ideal surrogate tissues for studying levels of mRNA, but inherent fragility and presence of salivary amylase limit RNA yield. Certain procedures were developed by us to increase RNA yield including use of the Copan buccal cheek cell collection device; Copan Diagnostics, Murrieta, CA. Genomic DNA is stable and mail-in self-collection kits are in general use, and DNA samples can be studied years later (Cozier et al., 2004). Buccal mRNA expression is of much greater utility in studying dynamic, mechanistic changes within at‐risk tissue during carcinogen exposure or pharmacologic intervention. For example, quantitative analysis of buccal gene expression has demonstrated differential expression of genes related to oxidative stress, oncogenesis, tumor suppression, and regulation of inflammation in smokers vs non‐smokers. However, the collection of RNA from buccal cells has inherent challenges that limit RNA yield. First, RNA is known for its rapid degradation, with half‐lives as brief as 12 minutes, necessitating rapid processing (Geiger et.al., 2021). Moreover, unlike genomic DNA, RNA can only be harvested from viable cells, which comprise only 5% to 23% of non‐invasively collected buccal cells, thus limiting the quantity of RNA per collection. Second, oral saliva contains RNAses that facilitate the first phase of digestion, which compromise both the quantity and quality of collected buccal RNA. Placing the buccal specimen into an RNA preservative markedly enhances yield; however, there is a need for specialized training, collection tools, and processing materials (Geiger et.al., 2021). Example 1 below describes studies that evaluate the use of buccal swabs to obtain and store RNA. The studies determined that buccal swabs can obtain enough RNA from buccal swabs such that RNA determinations can be made after the swabs are in storage for two years or longer, whether stored at room temperature or -80°C. The study also compared various swab types for amount of RNA obtained from buccal swabs. Thus, in some embodiments, a method is provided for isolating RNA from a swab sample. The method comprises obtaining the swab sample, storing the swab sample for more than two weeks and up to two years at any temperature between room temperature and -80°C inclusive, then isolating the RNA from the swab sample. Any swab known in the art to preserve nucleic acids can be used in the method. Nonlimiting examples include those made by Mawi, Puritan and Copan. In some embodiments, the swab is a Copan eNAT® swab. In these embodiments, the swab sample can be from any tissue, including but not limited to any liquid tissue source, such as urine, blood, buccal cells, nasal secretions, bile, feces, lymph, a skin secretion, acne, etc. In some embodiments, the swab sample is a buccal swab sample. At collection, the swab can be put into any solution that is capable of preserving RNA, for example eNAT® buffer (Copan) or another guanidine thiocyanate-based medium. The swab can be stored at any temperature in the recited range, including but not limited to fifteen days or more, more than three weeks, more than four weeks, more than two months, more than four months, more than six months, and more than one year, or any time in between. The swab can also be stored for more than 400 days, more than 500 days, and more than 600 days, more than two years, or any time in between. The swab can further be stored at any temperature between room temperature and -80°C, inclusive, for example 15°C, 10°C, 5°C, 0°C, -10°C, -20°C, -30°C, -40°C, -50°C, -60°C, -70°C, -80°C or any temperature in between. Any method known in the art can be used to isolate the RNA from the sample. In some of these embodiments, particularly when the swab is stored in sufficient RNAse inhibitors, the yield of the RNA from the swab sample stored for as long as two years is similar to the yield obtained for the swab sample stored two weeks or less before the RNA is isolated. mRNA Panel Differentially Expressed In Colorectal Cancer, Breast Cancer, And Bladder Cancer Cytokines and chemokines play an important role in cancer development and control. Cytokines affect the growth of all blood cells and other cells that help the body's immune and inflammation responses. They also help to boost anti-cancer activity by sending signals that can help make abnormal cells die and normal cells live longer. One specific type of cytokine is called a chemokine. The findings presented in this patent are based on the role that mRNAs are involved in the post-transcriptional regulation of cytokine expression. To illustrate, CCL27 is a chemokine that is overexpressed in certain types of squamous cell carcinoma and expressed at various levels in metastatic prostate, breast, colorectal, and pancreatic cancer as well as melanoma cell lines (Karnezis et al., 2019). The major human tissues in which CCL27 plays an important role in tumor progression and the main types of tumors which are influenced by CCL27 are discussed in Martinez et al., 2021. Chemokines such as CCL27 play an important role in mediating the recruitment of the appropriate immune cells to the tumor and establishing effective antitumor immunity. The key to this process is to recognize malignant cells which are eliminated by tumor-associated antigen- specific T cells, thereby preventing tumor progression (Pawelec, 2004). Another important example is STK11. The STK11 gene (also called LKB1) provides instructions for making an enzyme called serine / threonine kinase 11. This enzyme is a tumor suppressor, which means that it helps keep cells from growing and dividing too fast or in an uncontrolled way. Example 2 indicates that various combinations of mRNA levels of CCL27, KRT1, NR3C1, CASP3, STK11, GCKR, SLC6A3, NFKB1, EDAR, GH1, IL1A, SIRT1, PPARG, CRHR1, IL10, MMP13 and NFKB2 distinguish between non-cancer controls and the presence of bladder cancer, colorectal cancer and breast cancer. Thus, in some embodiments, a method of determining whether a patient has a cancer is provided. The method comprises a) measuring an mRNA level of at least one gene in a tissue of the patient, wherein the at least one gene is CCL27, KRT1, NR3C1, CASP3, STK11, GCKR, SLC6A3, NFKB1, EDAR, GH1, IL1A, SIRT1, PPARG, CRHR1, or the combination thereof; b) comparing the mRNA level determined in a) with the mRNA level of the at least one gene from a negative tissue from a subject not diagnosed with cancer; wherein the patient has cancer if the mRNA level determined in a) is greater than the mRNA level from the negative tissue. In some embodiments, the method further comprises b)i) comparing the mRNA level determined in a) with the mRNA level of the at least one gene from a positive tissue from a subject diagnosed with cancer; wherein the patient has cancer if the patient mRNA level in a) is greater than the mRNA level from the negative tissue and the patient mRNA level in a) is similar to the mRNA level from the positive tissue. One combination identified in Example 2, CCL27 and KRT1, could distinguish between any of the three cancers from no cancer. Since those three cancer subtypes represent a very diverse set of cancers, it is likely that these markers can be used to determine whether a patient has any cancer or not. Thus, in some embodiments of these methods, the at least one gene is CCL27 and KRT1. In some these embodiments, the method further comprises if the patient has cancer, determine a cancer type of the cancer and treat the patient for the cancer or if the patient does not have cancer, recommend no cancer treatment or treatment for any symptoms the patient is exhibiting. In further embodiments, the cancer is bladder cancer, colon cancer, or breast cancer. In various embodiments of these methods, the at least one gene is KRT1 and the method determines whether the patient has colorectal cancer. In some of these embodiments, the method further comprises recommending treatment for colorectal cancer if the patient has colorectal cancer and recommending no treatment for colorectal cancer if the patient does not have colorectal cancer. In other embodiments, the method further comprises treating the patient for colorectal cancer if the patient has colorectal cancer and treating the patient for another disease or disorder if the patient does not have colorectal cancer. In additional embodiments of these methods, the at least one gene is CRHR1 and the method determines whether the patient has breast cancer. In some of these embodiments, the method further comprises recommending treatment for breast cancer if the patient has breast cancer and recommending no treatment for breast cancer if the patient does not have breast cancer. In other embodiments, the method further comprises treating the patient for breast cancer if the patient has breast cancer and treating the patient for another disease or disorder if the patient does not have breast cancer. In further embodiments of these methods, the at least one gene is CCL27, IL1A, KRT1, EDAR or any combination thereof, and the method determines whether the patient has bladder cancer. In some of these embodiments, the method further comprises recommending treatment for bladder cancer if the patient has bladder cancer and recommending no treatment for bladder cancer if the patient does not have bladder cancer. In other embodiments, the method further comprises treating the patient for bladder cancer if the patient has bladder cancer and treating the patient for another disease or disorder if the patient does not have bladder cancer. In other embodiments of these methods, the at least one gene is CCL27, KRT1 or the combination thereof, and the method determines whether the patient has bladder, breast or colorectal cancer. In some of these embodiments, the method further comprises testing the patient for cancer type if the method determines that the patient has bladder, breast or colorectal cancer. Example 2 also establishes by machine learning that mRNA levels of the combination of IL10, KRT1, MMP13, NFKB2, and STK11 as well as the combination CCL27, KRT1, NR3C1, CASP3, and CRHR1 in a tissue of a patient can differentiate between (a) breast cancer and no cancer in the patient or (b) any cancer and no cancer in the patient. Thus, also provided is a method of determining whether a patient has a cancer. the method comprises a) measuring mRNA levels of (i) IL10, KRT1, MMP13, NFKB2, and STK11 and / or (ii) CCL27, KRT1, NR3C1, CASP3, and CRHR1; b) comparing the mRNA levels determined in a) with (A) the mRNA levels of (i) and / or (ii) from a negative tissue from a subject not diagnosed with cancer and b) and (B) the mRNA level of (i) and / or (ii) from tissue from a subject diagnosed with cancer; wherein the patient has cancer if the mRNA levels determined in a) is different than the mRNA levels determined in (A) and not different from the mRNA levels determined in (B), and the patient does not have cancer if the mRNA levels determined in a) is not different than the mRNA levels determined in (A) and different from the mRNA levels determined in (B). In some of these embodiments, the cancer is breast cancer. In other of these embodiments, this method further comprises if the patient has cancer, determine a cancer type of the cancer and treat the patient treatment for the cancer or if the patient does not have cancer, recommend no cancer treatment. Example 2 also provides results for 240 models using 5-gene combinations to distinguish breast cancer vs. no breast cancer, where the model achieves an F-score of greater than or equal to 0.85. Table 9 lists those combinations. Example 2 additionally provides results for 3285 models using 6-gene combinations to distinguish breast cancer vs. no breast cancer, where the model achieves an F-score of greater than or equal to 0.85. Table 10 lists those combinations. Thus, in various embodiments, a method of determining whether a patient has breast cancer is provided. The method comprises a) measuring mRNA levels of any combination of (i) 5 genes listed in Table 9, or (ii) 6 genes listed in Table 10, in a tissue of the patient; b) comparing the mRNA levels determined in a) with (A) the mRNA levels of the combination of 5 genes from a tissue from a subject not diagnosed with breast cancer and (B) the mRNA levels of the combination of 5 genes from tissue from a subject diagnosed with breast cancer; wherein the patient has breast cancer if the mRNA levels determined in a) is different than the mRNA levels determined in (A) and not different from the mRNA levels determined in (B), and the patient does not have breast cancer if the mRNA levels determined in a) is not different than the mRNA levels determined in (A) and different from the mRNA levels determined in (B). As used herein, “any combination of 5 genes listed in Table 9” or “6 genes listed in Table 10” refers to the genes in any particular row of Table 9 or Table 10, respectively. In some embodiments, the method further comprises treatment of the patient for breast cancer if the patient is determined to have breast cancer, or recommending no treatment for breast cancer if the patient does not have cancer. The determinations of whether a patient has cancer or not can also be used to determine the effectiveness of a cancer treatment, e.g., by measuring mRNA levels of a patient undergoing a treatment for cancer and determining whether the mRNA levels are higher, lower, similar or not similar to those of patients with cancer and patients without cancer. Thus, also provided herewith is a method of determining effectiveness of a treatment of a patient for cancer. The method comprises measuring a first mRNA level of at least one gene in a tissue of the patient before the treatment, wherein the at least one gene is CCL27, KRT1, NR3C1, CASP3, STK11, GCKR, SLC6A3, NFKB1, EDAR, GH1, IL1A, SIRT1, PPARG, CRHR1 or the combination thereof; treating the patient with the treatment; measuring a second mRNA level of the at least one gene in the tissue of the patient after the treatment; comparing the first mRNA level with the second mRNA level, wherein if the first mRNA level is lower than the second mRNA level with any of the genes except IL1A and / or EDAR, and / or if the first mRNA level of IL1A and / or EDAR is greater than the second mRNA level, then the treatment is effective, and if the first mRNA level is not lower than the second mRNA level with any of the genes except IL1A and / or EDAR, and / or if the first mRNA level of IL1A and / or EDAR is not greater than the second mRNA level, then the treatment is not effective. In some embodiments of these methods, the at least one gene is CCL27 and KRT1. In other embodiments, the cancer is bladder, breast or colorectal cancer. In further embodiments, the at least one gene is CCL27, KRT1, NR3C1, CASP3 or any combination thereof. In additional embodiments, the at least one gene is CCL27, KRT1 or the combination thereof. In other embodiments, the at least one gene is KRT1 and the method determines whether the a treatment for colorectal cancer is effective. In some of these embodiments, the method further comprises recommending continuing the treatment for colorectal cancer if the treatment for colorectal cancer is effective and recommending changing the treatment for colorectal cancer if treatment for colorectal cancer is not effective. In other embodiments, the method further comprises continuing the treatment for colorectal cancer if the treatment for colorectal cancer is effective and changing the treatment for colorectal cancer if treatment for colorectal cancer is not effective. In additional embodiments, the at least one gene is CRHR1 and the method determines whether the treatment for breast cancer is effective. In some of these embodiments, the method further comprises recommending continuing the treatment for breast cancer if the treatment is effective and recommending changing the treatment for breast cancer if the treatment is not effective. In other embodiments, the method further comprises continuing the treatment for breast cancer if the treatment is effective and changing the treatment for breast cancer if the treatment is not effective. In further embodiments, the at least one gene is CCL27, IL1A, KRT1, EDAR or any combination thereof, and the method determines whether the treatment for bladder cancer is effective. In some of these embodiments, the method further comprises recommending continuing the treatment for bladder cancer if the treatment is effective and recommending changing the treatment for bladder cancer if the treatment is not effective. In other embodiments, the method further comprises continuing the treatment for bladder cancer if the treatment is effective and changing the treatment for bladder cancer if the treatment is not effective. Also provided is another method of determining effectiveness of a treatment of a patient for cancer. The method comprises measuring mRNA levels of IL10, KRT1, MMP13, NFKB2, and STK11 in a tissue of the patient before the treatment; treating the patient with the treatment; measuring second mRNA levels of IL10, KRT1, MMP13, NFKB2, and STK11 in the tissue of the patient after the treatment; comparing the first mRNA level with the second mRNA level, wherein if the second mRNA level is more similar to mRNA levels of IL10, KRT1, MMP13, NFKB2, and STK11 in the tissue of an individual without cancer than the mRNA levels before treatment, then the treatment is effective, or if the second mRNA level is not more similar to mRNA levels of IL10, KRT1, MMP13, NFKB2, and STK11 in the tissue of an individual without cancer than the mRNA levels before treatment, then the treatment is not effective. In some of these embodiments, the cancer is breast cancer. In other embodiments, the method further comprises recommending continuing the treatment if the treatment is effective and recommending changing the treatment if the treatment is not effective. In further embodiments, the method further comprises continuing the treatment if the treatment is effective and changing the treatment if the treatment is not effective. Additionally provided is a method of determining effectiveness of a treatment of a patient for breast cancer. The method comprises measuring first mRNA levels of any combination of 5 genes listed in Table 9 in a tissue of the patient before the treatment; treating the patient with the treatment; measuring second mRNA levels in the tissue of the patient after the treatment; comparing the first mRNA levels with the second mRNA levels, wherein if the second mRNA levels are more similar to mRNA levels of the 5 genes in the tissue of an individual without breast cancer than the mRNA levels before treatment, then the treatment is effective, or if the second mRNA levels are not more similar to mRNA levels in the tissue of the individual without cancer than the mRNA levels before treatment, then the treatment is not effective. Any tissue can be utilized in any of the above methods, from any solid or liquid tissue source, e.g. a metastatic tumor. In some embodiments, the tissue is from a liquid tissue source, e.g., urine, blood, saliva, buccal cells, nasal secretions, bile, feces, lymph, a skin secretion, acne, etc. In some of these embodiments, the swab sample is a buccal swab sample. The patient tissue sample and the negative tissue sample are preferably from the same tissue. The mRNA level can be measured by any means known in the art. Nonlimiting examples include northern blotting, dot blotting, ribonuclease protection assays (RPAs), serial analysis of gene expression (SAGE), differential or subtractive hybridization, quantitative PCR (qPCR), digital PCR (dPCR), and next generation sequencing (NGS), as these methods are known in the art. The determination of whether any particular mRNA level is greater, less than, different than, or the same as, another mRNA level can be made using statistical methods known in the art, with consideration of degree of type 1 and type 2 errors desired. When a patient is determined to have cancer using the methods described below, treatment for the relevant cancer is often recommended, initiated or continued. Anticancer treatments Treatment plans for most cancers may include a combination of chemotherapy, targeted cancer cell therapy, immunotherapy, surgery, and radiation therapy, which can be used to slow the spread of the disease and shrink a cancerous tumor. Palliative care will also be important to help relieve symptoms of cancer and side effects of treatment. Chemotherapy uses strong medicines to kill cancer cells. For example, chemotherapy for colon cancer is usually given after surgery if the cancer is large or has spread to the lymph nodes. Chemotherapy can kill cancer cells that might be left after surgery. This helps reduce the risk of the cancer coming back. Chemotherapy might also be used before surgery to shrink a large cancer so that it's easier to remove. Chemotherapy also can be used to relieve symptoms of colon cancer that can't be removed with surgery or that has spread to other areas of the body. Sometimes it's used with radiation therapy. Chemotherapy usually works by attacking rapidly dividing cells. This means that chemotherapy can harm not only cancer cells but also healthy cells that are dividing rapidly, like the ones that cause your hair to grow. Radiation therapy uses powerful energy beams to kill cancer cells. The energy can come from X- rays, protons or other sources. Radiation therapy can shrink a large cancer before an operation to make it easier to remove. When surgery isn't an option, radiation therapy might be used to relieve symptoms, such as pain. Some people have radiation and chemotherapy at the same time. Targeted therapy uses medicines that attack certain chemicals in cancer cells. By blocking these chemicals, targeted treatments can cause cancer cells to die. Immunotherapy is a treatment with medicine that helps the body's immune system kill cancer cells. Cancer cells survive by hiding from the immune system. Immunotherapy helps the immune system cells find and kill the cancer cells. Colon Cancer: Surgery: The treatment of choice for colon cancer is surgical resection, which involves removing the cancer through surgery. Surgery is performed to remove the cancer completely and reconstruct the bowel, if possible, so a patient’s postoperative bowel function is normal or near normal. Standard chemotherapy for colorectal cancer: Capecitabine (Xeloda), a pill that is changed into 5- FU once it gets to the tumor. Irinotecan (Camptosar) Oxaliplatin (Eloxatin) Trifluridine and tipiracil (Lonsurf), a combination drug in pill form. Immunotherapy is usually reserved for advanced colon cancer. Breast Cancer: Breast cancer is primarily treated with surgery and often combined with chemotherapy, radiation therapy or both. It may also include other treatment options like targeted therapy, proton therapy and angiogenesis inhibitors. Surgery is often the first treatment for breast cancer. Chemotherapeutic drugs include, but are not limited to, the following commonly used agents: - anthracyclines, such as doxorubicin - cyclophosphamide (Cytoxan®) - epirubicin (Ellence®) - fluorouracil - methotrexate (Rheumatrex®, Trexall®) - taxanes, such as paclitaxel (Taxol®) Early-stage breast cancer can be treated with combination chemotherapy. Combination drug therapy means that you receive more than one type of drug at a time. If a tumor becomes resistant to one drug, your treatment may still be effective because the tumor responds to the second or third drug in the combination you receive. Combination therapy can be given before or after breast surgery. Most patients receive a combination of two or three drugs at the same time. Some of these drugs are breast cancer targeted therapies. These drugs work by targeting specific molecules involved in breast cancer development. Drug combinations that medical oncologists commonly prescribe: Dose-Dense AC-T Chemotherapy - Doxorubicin and cyclophosphamide, followed by paclitaxel - Used to treat early-stage breast cancer, particularly in younger women or women with aggressive disease - Given intravenously before or after surgery Dose-Dense AC-TH Chemotherapy and Targeted Therapy - Doxorubicin and cyclophosphamide, followed by paclitaxel and trastuzumab (Herceptin®) - Used to treat early-stage HER2-positive breast cancer - Given intravenously before or after surgery Dose-Dense AC-THP Chemotherapy and Targeted Therapy - Doxorubicin and cyclophosphamide, followed by paclitaxel, trastuzumab, and pertuzumab (Perjeta®) - Used to treat early-stage breast cancer - Given intravenously before or after surgery Chemotherapy drugs that are commonly prescribed for advanced breast cancer include: - albumin-bound paclitaxel (Abraxane®) - carboplatin - capecitabine (Xeloda®) - docetaxel - eribulin (Halaven®) - etoposide (VP16, Etopophos®) - gemcitabine (Gemzar®) - irinotecan (Camptosar®) - liposomal doxorubicin (Lipodox®) - paclitaxel - vinorelbine (Navelbine®) Bladder cancer: Drugs Approved for Bladder Cancer - Adstiladrin (Nadofaragene Firadenovec-vncg) - Avelumab - Balversa (Erdafitinib) - Bavencio (Avelumab) - Cisplatin - Doxorubicin Hydrochloride - Enfortumab Vedotin-ejfv - Erdafitinib - Jelmyto (Mitomycin) - Keytruda (Pembrolizumab) - Mitomycin - Nadofaragene Firadenovec-vncg - Nivolumab - Opdivo (Nivolumab) - Padcev (Enfortumab Vedotin-ejfv) - Pemazyre (Pemigatinib) - Pembrolizumab - Pemigatinib - Sacituzumab Govitecan-hziy - Tepadina (Thiotepa) - Thiotepa - Trodelvy (Sacituzumab Govitecan-hziy) - Valrubicin - Valstar (Valrubicin) Drug Combinations Used in Bladder Cancer - Gemcitabine-Cisplatin - MVAC Chemotherapy into the bladder (intravesical chemotherapy) is a treatment for non-muscle invasive bladder cancer. The medication is given through a flexible tube called a catheter, which goes into the bladder. Intravesical chemotherapy reduces the chance of the cancer coming back or spreading. Intravesical chemotherapy is different to chemotherapy treatment for muscle invasive bladder cancer. Muscle invasive means the cancer has spread into or through the muscle layer of the bladder. Non muscle invasive bladder cancer or superficial bladder cancer means the cancer cells are only in the bladder’s inner lining. The most common treatments for non-muscle invasive bladder cancer are: - surgery - chemotherapy into the bladder - Instillation of a vaccine called BCG into your bladder The most common regimens for systemic, or whole-body, chemotherapy to treat bladder cancer include cisplatin and gemcitabine, carboplatin (available as a generic drug) and gemcitabine, and MVAC, which combines 4 drugs: methotrexate (Rheumatrex, Trexall), vinblastine (Velban), doxorubicin, and cisplatin. Targeted mRNA delivery system using exosomes The employment of exosomes, about 100 nm sized extracellular vesicles, as a natural drug delivery vehicle with the capability to deliver a wide range of therapeutics including genetic material into the cells inflicted with cancer. Exosomes, intracellular communication vesicles with diverse compositions, play pivotal roles in both biological and pathological processes. Leveraging their optimal size and ability to transfer biological cargo to recipient cells, these vesicles serve as promising drug delivery vehicles. Positive properties of exosomes include biocompatibility, preferred tumor homing, adjustable targeting, efficiency, and stability. Exosomes can be used to deliver nucleic acids as a cargo within their structure. They shield the contained cargo from degradation and damage and facilitate precise target delivery. Moreover, exosomes have low immunogenicity and toxicity which make exosomes ideal candidates for designing delivery systems. An innovative manufacturing technique that effectively incorporates nucleic acids into exosomes during their synthesis within host cells is available. Nucleic acid medicine has long been of interest as the next generation of polymer drugs following proteins. However, there are issues such as the easy degradation of nucleic acids in the body, strong immune reactions caused by nucleic acids themselves, and difficulties in efficiently delivering them to the target cells. Drug Delivery Systems (DDS) are considered essential for addressing these issues, as they prevent nucleic acid degradation, protect against immune reactions, and facilitate uptake by target tissues and cells, thus promoting the widespread use of nucleic acid pharmaceuticals. The potential of nucleic acids in medical applications is extremely high, particularly in controlling genes that have been difficult to target with conventional small molecules and proteins. By directly targeting gene sequences, highly specific therapeutic effects are expected. Currently, nucleic acid pharmaceutical development is taking place worldwide, and there is a vast array of candidate drugs. However, as mentioned above, there is a delay in the development of DDS that can effectively deliver nucleic acids to target cells. On the other hand, exosomes are extracellular vesicles surrounded by a lipid membrane that is similar to the cell membrane and naturally secreted by various cells. They contain intracellular substances derived from the cytoplasm. The substances enclosed within the lipid membrane not only receive protection from metabolic enzymes but also have the ability to freely pass through tissues and even cell membranes. The surface of exosomes is covered with various membrane proteins, which we can easily modify. These membrane proteins can facilitate the uptake of exosomes by specific target cells, allowing the release of their internal cargo. The characteristics of exosomes, which can transport substances to distant cells, make them ideal for a drug delivery system. Exosomes, which exist in blood and body fluids, not only contain cytoplasmic proteins and RNA as previously reported but also incorporate DNA. Furthermore, exosomes from cancer patients contain a significant amount of DNA (Sayeed & Sugaya, 2022). These exosomes comprise novel signal nucleotide sequences inserted into the 3’-end non-coding regions. (Id.) DNA with and without this special nucleotide sequence are also in the cytoplasm. However, the DNA contained in exosomes predominantly had this special nucleotide sequence, suggesting that it is selectively incorporated into exosomes due to its presence. This DNA is not waste material from the genome but rather strongly indicates that when RNA is reverse transcribed in the cytoplasm, the gene with this nucleotide sequence is transferred to exosomes. Based on this novel finding, a technique was developed for efficiently incorporating specific nucleic acids into exosomes produced by the human cells, such as mesenchymal stem cells (Sayeed & Sugaya, 2022; Smith, 2023, US Patent 11,193,174; Patent Publications US2023 / 0212566; US2022 / 0348867; and WO2023 / 055799). Scientific Rationale Relevant to the Disease / Condition: A therapeutic exosome formulation can target cancers such breast, colorectal, and bladder. These exosomes are engineered to express a cellular or tissue specific homing peptide on their surface, facilitating their specific delivery to cells or tissues with cancer. This delivery platform can be used in genetic therapy to improve accuracy, efficiency and stability of the treatment. Upon administration, exosomes guided by the specific cellular or tissue homing peptide effectively navigate to the cancer site. Within these exosomes, there is an mRNA, microRNA, short hairpin RNA (shRNA), siRNA or a DNA gene cassette, which produces shRNA that specifically targets cancer embryonic stem cells. The shRNA suppresses the expression of embryonic stem cell genes pivotal in tumor development and treatment resistance. The essential aim is to sensitize cancer stem cells to specific anticancer drug therapy. shRNA is an RNA molecule with a tight hairpin turn that can be used to silence gene expression via RNA interference (RNAi). RNA interference (RNAi), also known as gene silencing, is a biological process that prevents gene expression in certain diseases such as cancer. siRNA is a double-stranded ncRNA with a length of 20–25 base pairs that are loaded onto the RNA-induced silencing complex (RISC), to degrade and cleave the mRNA before translation (Watts and Corey, 2012; Ferguson et al., 2020). siRNAs degrade mRNAs, which contain complementary nucleotide sequences, after transcription to interfere with the expression of specific genes. Schematic illustration of RNAi mechanism. siRNA binds to RISC after entering cytoplasm. The antisense chain is loaded onto the RISC, and the sense chains are discarded. The antisense chain then causes the target mRNA to be specifically cut and degraded. (Reference: Front. Pharmacol., 15 March 2021. Sec. Pharmacology of Anti-Cancer Drugs. Insight Into the Prospects for RNAi Therapy of Cancer). A major factor contributing to the treatment resistance of cancer is the presence of cancer stem cells (CSCs). CSCs have been identified in various cancers within the brain, heart, breast, colorectal and lung (Singh, et al. 2003). CSCs possess self-renewal and high-differentiation capabilities, which are characteristics of stem cells (Bonnet, 1997). These cells play a pivotal role in cancer progression, facilitating uncontrolled cell proliferation, metastasis, and the initiation of new tumor formation. Cell surface markers can distinguish CSCs from other cells; these markers include CD24, CD29, CD44 and CD133 (Geng, 2013). The drug resistance of CD133-positive cells has been confirmed in various types of cancer (Liu et al. 2006.). CSCs, also known as tumor initiating cells (TICs), are at least partially responsible for drug resistance and cancer relapse due in part to their ability to self-renew themselves and differentiate into heterogeneous lineages of cancer cells. CSCs evade conventional therapies by remaining dormant, have increased DNA repair capacity, turn off apoptotic pathways, and also can manipulate the tumor microenvironments to their advantage (Dirks, 2008). The resistance of CSCs to anticancer agents is attributed to their stemness properties (Hoyt, et al.2023). The concept of embryonic stemness genes or cancer stemness cells (CSCs) applies to cancers throughout the body including brain, heart, breast, colorectal and lung (Singh, et al. 2003). CSCs possess self-renewal and high-differentiation capabilities, which are characteristics of stem cells (Bonnet & Dick,1997). As established above, mRNA transcripts such as CCL27 and KRT1 have increased expression in patients with bladder and colorectal cancer. The presence of these transcripts also provides a therapy utilizing these specific mRNA transcripts. CCL27 illustrates the significance of the exosome treatment, however, the background and explanations that follow are generic and can be applied to most cancers that develop in a mammalian organism, as well as the other listed 48 mRNA cytokine / chemokine biomarkers, including but not limited to KRT1, IL1A, CRHR1, and EDAR. Human skin tumors evade T cell-mediated antitumor immune responses by down-regulating the expression of the skin-specific homeostatic chemokine CCL27 through the activation of epidermal growth factor receptor (EGFR) and Ras signaling pathways. The interference of tumor cells with the recruitment of “surveillance” T cells to sites of tumor progression by down-regulating homeostatic CCL27 expression represents a unique tumor immune escape mechanism (Pivarcsi, 2007). The mammalian body is protected by barriers, such as the skin, and mucosa that lines organs exposed to the environment, such as the mouth, bladder, colon, and rectum. Abundant immune cells reside in these barrier tissues. CCL27 is a chemokine predominantly expressed by skin keratinocytes (Baird et al., 1999). CCL27 has also been detected in mucosal sites of lungs and reproductive tracts (Menzies et al., 2020). Davila and coworkers demonstrated that CCL27 is critical for immune homeostasis across barrier tissues (Davila et al., 2022). Endometriosis represents a good example of the association between CCL27 and a disease that affects many women and is inflammatory driven. Ruan and colleagues found that CCL27 was aberrantly elevated in endometriosis. The knockdown of CCL27 suppressed endometriosis progression by inhibiting cell growth, metastasis and adhesion in ESCs. These repressed processes are mediated by the JAK2 / STAT3 pathway inactivated by silencing CCL27 in endometriosis. Thus, abnormally expressed CCL27 appears to function as a stimulative factor in the development of endometriosis (Ruan, 2016). As discussed therein, “…over-expressed CCL27 contributed to the promotion of proliferation, metastasis and adhesion in ESCs separated from endometriotic patients, through up-regulating MMP2, MMP9, CD44 and ICAM1 and activating JAK2 / STAT3 signaling pathway. This may provide a novel therapy target for the treatment of endometriosis.” The importance of CCL27 as related to cancer is shown by Wu and colleagues that JAK / STAT3 signaling was involved in metastasis in endometrial cancer cells by regulating intracellular levels of MMP2 and MMP9 (Wu, 2012). Exosomes can be produced from various cell types, including human stem cells and plant cells. The exosome can be loaded with a specific siRNA targeting an overactive gene contributing to cancer, such as CCL27, or with an mRNA of an underactive gene contributing to cancer, such as IL1A or EDAR (See, e.g., Table 7). A specifically created homing peptide can be attached to each exosome for targeted delivery to certain cells, tissues or organs. Routes of administration include but are not limited to intranasal, oral, intravenous, intraperitoneal, subcutaneous and topical. Based on the above discussion, exosomes that modify the expression of any of the genes described above that express either elevated or reduced mRNA levels with cancer can be effective treatments for the cancer. Thus, in various embodiments, an exosome comprising at least one siRNA targeting a gene is provided. In these embodiments, the siRNA reduces expression of the gene that is elevated in cancer. In these embodiments, the gene is CCL27, KRT1, NR3C1, CASP3, STK11, GCKR, SLC6A3, NFKB1, EDAR, GH1, IL1A, SIRT1, PPARG, CRHR1 or any combination thereof. In some of these embodiments, the at least one gene is CCL27, KRT1, NR3C1, CASP3 or any combination thereof. In various embodiments, the exosome inhibits breast, bladder or colorectal cancer when administered to a patient having breast, bladder or colorectal cancer. In other embodiments, the at least one gene is KRT1. In some of these embodiments, the exosome inhibits colorectal cancer when administered to a patient having colorectal cancer. In additional embodiments, the at least one gene is CCL27. In some of these embodiments, the exosome inhibits skin cancer (e.g. melanoma) when administered to a patient having skin cancer. In other of these embodiments, the exosome inhibits endometriosis when administered to a patient having endometriosis. In further embodiments, the at least one gene is CRHR1. In some of these embodiments, the exosome inhibits breast cancer when administered to a patient having breast cancer. It is noted that expression of the genes IL1A and EDAR is reduced in bladder cancer (Table 7 above). Thus, increasing expression of those genes, using an exosome loaded with the mRNA of those genes, would be expected to be an effective treatment for bladder cancer. Thus, in some embodiments, provided is an exosome comprising at least one mRNA of a gene, wherein the gene is IL1A, EDAR or the combination thereof. In some of these embodiments, the exosome inhibits bladder cancer when administered to a patient having bladder cancer. Also provided is a method of treating bladder cancer, breast cancer, colorectal cancer, skin cancer (e.g., melanoma) or endometriosis in a patient. The method comprises administering the appropriate exosome described above to the patient to treat the cancer or endometriosis. Preferred embodiments are described in the following examples. Other embodiments within the scope of the claims herein will be apparent to one skilled in the art from consideration of the specification or practice of the invention as disclosed herein. It is intended that the specification, together with the examples, be considered exemplary only, with the scope and spirit of the invention being indicated by the claims, which follow the examples. EXAMPLES Example 1: Optimizing collection and analysis of buccal swabs for RNA collection Summary The use of the eNAT COPAN swabs for the sample collection of buccal cells and subsequent RNA isolation using the Maxwell RSC 48 (Promega), has been confirmed as a great combination of tools not only for the yield obtained, but also the quality and quality of the final nucleic acid product RNA Data isolation This study sought to determine the optimal swab type for the collection and analysis of mRNA. The sample collection was performed on healthy laboratory voluntary members aged ≥18 years able to perform their collection of buccal cells, by applying pressure against the buccal mucosa of both sides of the moth with movements up and down and around the different areas for at least 1 minute. Four swab types were tested: 30 Mawi, Puritan DNA / RNA Shield, Puritan PurSafe, and eNAT® system Copan. eNAT® swabs have the advantage of inactivating microbial agents and denaturing proteins, allowing sager sample handling in the laboratory. After the collection, the swabs were then immediately placed back inside the tube of the collection containing transport medium for the preservation and stabilization of nucleic acids compatible with numerous molecular assays and previously used for HPV molecular detection (Juliana et al.2020; Seyoum et al., 2023) RNA isolation After the collection, the samples were vortexed for at least 3 minutes and a volume of 300µl of the samples was pipette off. By using the Kingfisher platform with the MagMAX™ mirVana™ Total RNA Isolation Kit (ThermoFisher Scientific) using deep well plates where the samples were first lysate and banded with beads before starting the processing in the platform (Kingfisher -ThermoFisher Scientific) and diluting the sample in ~40ul of elution buffer. By using the Maxwell RSC 48 (Promega), with the kit Maxwell® RSC miRNA Plasma and Serum, with the same initial volume of 300µl, and after the preliminary vortex of the samples, an equal volume of Lysis Buffer was added to the 1.5ml Lobind tube where was previously pipetted the sample, plus 30µl of Proteinase K. This 630 µl were vortexed for about 10sec and incubates at 56C for 20 minutes before placed the total volume into the cartridge to start the automated process of insulation in the mentioned Promega platform. The final product was diluted in 40 µl of elution buffer and storage at -80C Negative control, consisting of a sterile microcentrifuge tube serving as a reagent blank, was included in each round of extraction and processed in the same manner as test samples. Quantification mRNA concentration was measured by the Invitrogen Qubit 4 Fluorometer (ThermoFisher Scientific) using (1ul per sample) with the Qubit RNA High Sensitivity (HS) Assay kit (ThermoFisher Scientific) that is highly selective for RNA over DNA, protein, and free nucleotides, allowing the comparison of yields across the different swabs to determine the concentrations, the total yield (in nanograms) of mRNA isolated from each swab, based on the final elution volume, averages, median, and standard deviations (SD) were calculated across each swab type using Excel Microsoft. Results The Copan swabs had the highest yield (~1198.67 ng and 998.93 ng) followed by the Mawi swabs (~915 ng) and both Puritan swabs (PurSafe and Shield) with lower values (~679.6 ng and 348.48 ng respectively). (Table 1 and 2; FIG. 1). The Copan swab used in this experiment was 1 FLOQ, and a tube with 1 mL eNAT transport and preservation medium (Cat# 608CS01R).

[0002] Table 1: Total RNA yield from each swab type tested (total volume of 40 ul); data amounts refer to total RNA yield of each sample tested, from specific individuals. The primary endpoint was the practical assessment of whether sufficient RNA was present for downstream molecular analysis, that is, did the total quantity exceed a predetermined threshold concentration. The ultimate goal was to obtain adequate buccal cell RNA for gene expression studies by quantitative RT‐PCR. Wet Lab experiment studying relationship of isolated mRNA extracted to importance of temperatures COPAN swabs and Temperature study Following the COPAN recommendations, we tested a total of 160 swabs that were collected and used for this RNA isolation study and storage at room temperature and ultra-low temperature (Table 2). Table 2: Samples used. Type N Bladder 34 Cancer Breast 27 Colorectal 24 Controls 75 TOTAL N=160 All three types of cancer samples (Bladder, Breast, and Colorectal) were manipulated following the COPAN commendations. All samples were stored at room temperature after arriving at the laboratory, with a range between 1 to 15 days for the bladder cancer samples; 1 to 32 days for the colorectal cancer samples, and 4 to 27 days for the breast cancer samples, before placing all of them inside the ultra-low freezer. All samples were stored at -80°C for extensive periods that varied between 4 to 144 days for the bladder cancer samples: 39 to 335 days for the breast cancer samples, and between 39 and 420 days for the colorectal cancer samples (Table 3). Table 3. Days stored at room temperature (RT) and at -80°C. at RT at -80°C Bladder 1 to 15 days 4 to 144 days Breast 4 to 27 days 39 to 335 days Colon 1 to 32 days 39 to 420 days Controls 0 to 630 days 25 to 593 days The control samples (N=75) followed a similar procedure. These samples were stored at room temperature after arriving at the lab between 0 and 630 days, before storing at -80°C (from 25 to 593 days). After being stored at -80°C, the samples were de-frozen, and the RNA was isolated using Maxwell RSC 48 (Promega). FIGS. 2, 3 and 4 show the concentration (ng / ul) of each cancer sample (i.e. Bladder, Breast, and Colorectal) respectively, after being stored in the ultra-low freezer. These plots show no significant differences based on the time the samples were stored at -80°C, confirming that the low temperature of storage doesn’t affect the quantity of RNA isolated. The control samples also were submitted to long periods of storage at room temperature and at - 80C. In this case, it’s possible to observe that long periods of storage at room temperature, before placing the buccal swabs inside the ultra-low freezer didn't affect the samples and the quantity of RNA isolated. (FIG.5) Example 2: Identifying genes differentially expressed in cancer Summary We have built a machine learning pipeline that takes in raw quantitative mRNA measurements from our custom chip, and classifies subjects based on their estimated presence or absence of certain cancers. For breast cancer, we observe success in identifying positive cancer patients using a support vector machine classifier leveraging an RBF kernel function and reasonable parameter settings (C=1.0, gamma=auto). Using these settings for k-fold stratified cross-validation experiments, we see an average 91.3% sensitivity (mean F1=0.736) when we use all biomarker information coming off the chip, and an average 97.1% sensitivity using only signal from CCL27 (mean F1=0.744). Materials and Methods Observational Protocol: Quantitative mRNA data underwent genetic analyses leveraging machine learning-derived embedding and clustering to identify markers of genetic expression involved in cancer. Study population and recruitment: Patients with personal cancer history were admitted into the study. Various cancer types accepted include but are not limited to breast cancer, colorectal cancer, bladder cancer, intestinal cancers, gynecologic cancer, skin cancer, lung cancer, and lymphatic system cancers. Physician consultation and / or genetic consultation were obtained for each individual enrollee, as needed. Genetic Testing: Genomic RNA was extracted from a buccal swab sample using a standard kit. The individual to be tested swabbed the right and left cheeks with a cotton swab and placed the swabs in envelopes or tubes labeled specifically for RNA analysis. We created a custom chip for reading candidate mRNA-based cytokine biomarkers, selected, based on association with inflammatory pathways and other systems of interest in development of cancers. Our final chip quantified expression levels of the following 48 mRNAs (“the 48 mRNAs”): ABCAI, ADAMTS4, CACNAIC, CASPI, CASP3, CASP9, CCL27, CRHRI, EDAR, EPO, FGFR2, FKBP5, GCKR, GHI, HAMP, HFE, HFE2, IGFI, IL-l(ILIA), IL-10, IL-18, IL-IB, IL-6, KRT1, KRT83, MMP13, MUCI, NFKBI, NFKB2, NLRP3, NLRPI, NR3Cl, PAX8, PDLI(CD274), PPARG, RGS2, SDKI, SIRTI, SKA2, SLC11A2, SLC22A4, SLC40Al, SLC6A3, SMAD3, STK11, TGFB1, TNF, VEGFA. See also PCT Patent Application PCT / US23 / 74690. The genes in this chip that are not further listed in Table 8 below did not individually show any significant differential expression between the studied cancers or between the cancer and no cancer. Wet Lab Methods Description: Sample collection of cheek cells was carried out with flocked swabs that were immediately placed in a screw cap tube containing 0.5 ml of molecular collection and preservation medium (eNAT®, Copan). A flocked swab is advantageous because the swab provides optimum sample collection and stabilizes and preserves nucleic acid for prolonged periods of time. Sample integrity was maintained at ambient temperature for transportation via regular post. The transport media and stabilizing liquid helped to keep the sample protected, minimizing the growth of bacteria until processing can take place. Samples were stored at a low temperature in the lab. Extraction was performed using a compact, automated nucleic acid purification platform that processes up to 48 samples simultaneously. This procedure uses paramagnetic particles to provide a mobile solid phase to optimize sample capture, washing, and purification of nucleic acid. As soon as the run was complete, samples were extracted and placed on ice. Samples were quantified using a benchtop fluorometer to measure the RNA concentration (ng / µL). Following the quantification, the RNA sample concentration was normalized all samples to the same final concentration. We used multiplexing to help maximize the use of the ever-increasing capacity of Next Generation Sequencing (NGS) technology, allowing us to run multiple libraries while minimizing costs. Before starting the library, RNA samples were subjected to a process via reverse transcription that produces complementary DNA (cDNA). For this process the reverse transcriptase (RTs) uses an RNA template and a short primer complementary to the 3' end of the RNA to direct the synthesis of the first strand cDNA. The construction of sequencing libraries started with the cDNA target amplification, where the specific panel designed for this study was incorporated into the samples and amplified. A partial digest of the amplicons was carried out, generating the specific amplicons needed. Ligation reaction included the addition of unique adapters or barcodes to each of the samples, followed by a purification of the library, where all the excess reagents added were removed. Following this, we normalized all libraries included in the same batch, in this way during the sequencing process all the libraries were treated equally, as they will be present in similar concentrations. After a final cleanup in which all the excess components not used were removed, the libraries were ready for the last final step, which included polling libraries followed by sequencing. The resulting library was sequenced on a commercially available next-generation sequencer using commercially available reagents and kits. Output files were transferred to a bioinformatics pipeline for further analysis. Results and Analysis: Data analysis was performed using Applied Biosystems' Transcriptome Analysis Console (TAC) Software, from which we obtained a list of differentially expressed biomarkers. P-values and conditional false discovery rate-corrected p-values (FDR) from F-tests were used to filter genes, where FDR is defined as the experiment-wise threshold for statistical significance. We report biomarkers as individually differentiable for the cancers in question when the respective FDR p-values are below the threshold of α=0.05; biomarkers achieving a p-value less than α without FDR correction were also considered significant. The following parameters were determined from the results: TP = true positive FP = false positive FN = false negative TN = true negative Precision: The proportion of positive predictions that were actually correct. precision = TP / (TP+FP) Recall (also, sensitivity): the proportion of true positives that were correctly identified. recall = TP / (TP+FN) F-measure (also, F1): the harmonic mean of precision and recall. F1 = (2 * precision * recall) / (precision + recall) Area Under the Curve (AUC): the ability of a classifier to distinguish between classes. The curve here is plotted in a space where the x-axis is the false positive rate, and the y-axis is the true positive rate. Subjects were excluded from the differential biomarker analysis if their cancer was labeled "metastatic", in an effort to decrease potential sources of noise. Following this, one additional breast cancer subject was removed because their quantified expression levels significantly differed from all other subjects. Tables 4-8 show our results comparing biomarker expression in various cancers. Importantly, all average log2 expression levels reported here are rounded to the hundredth place, so "0" does not necessarily indicate a true absence of expression levels. Tables 4-8. summarizing results on cancer-specific findings follow: Table 4: Differential expression of individual biomarkers for all cancer subtypes (Colorectal, Breast, and Bladder) versus non-cancer controls. Table 5: Differential expression of individual biomarkers for colorectal cancer versus non-cancer controls. KRT1 was significantly differentially expressed between cancer and non-cancer patients. Table 6: Differential expression of individual biomarkers for breast cancer versus non-cancer controls. CRHR1 was not significant at our false discovery rate, but we include the results here as we expect to see differences with additional data. Table 7: Differential expression of individual biomarkers for bladder cancer versus non-cancer controls. IL1A, KRT1, and EDAR were not significant at our false discovery rate, but we include the results here as we expect to see differences with additional data. In Table 4, we see differential expression of KRTl and CCL27 in breast, bladder and colorectal cancer using FDR p-values. We also saw differential expression of KRT1, CCL27, STK11, and PPARG in breast and colorectal cancer. We also observed differences in biomarker expression between bladder and colorectal cancer, particularly in IL1A and SMAD3. Finally, in bladder and colorectal cancers, we saw differential expressions of IL1A and CCL27 levels. We also performed a one-way ANOVA examining the relationship of cancer diagnosis to biomarker levels. Both FDR-corrected and uncorrected p-values are reported. Our results for this are shown in Table 8:

[0003] Table 8: Results of one-way ANOVA comparing cancer diagnosis and non-cancer controls with biomarker expression levels. Both FDR-corrected and uncorrected p-values are reported. F-test was performed over averaged log2readings. In order to identify additional associations of combinations of gene mRNA levels with cancer, we used normalized mRNA values of the 48 mRNAs to train a linear support vector machine classifier. Performance metrics are reported as the mean over 5x2 stratified cross-validation. Using that method, we identified the combination of IL10, KRT1, MMP13, NFKB2, and STK11 for distinguishing (a) breast cancer vs. no cancer controls, and (b) all three cancers vs. no cancer controls. A model using these the data from these five genes provided the following metrics: BREAST CANCER v. CONTROLS: Average Sensitivity: 0.957 Average Specificity: 0.743 Average F1: 0.836 Average AUC: 0.843 Average Sensitivity: 1.0 Average Specificity: 0.815 Average F1: 0.898 Average AUC: 0.678 Using the same methods as immediately above, we also identified the combination of CCL27, KRT1, NR3C1, CASP3, and CRHR1 for distinguishing (a) breast cancer vs. no cancer controls, and (b) all three cancers pooled vs. cancer-free controls. A model using these the data from these five genes provided the following metrics: BREAST CANCER v. CONTROLS: Average Sensitivity: 0.841 Average Specificity: 0.699 Average F1: 0.763 Average AUC: 0.697 POOLED CANCERS v. CONTROLS: Average Sensitivity: 0.987 Average Specificity: 0.812 Average F1: 0.891 Average AUC: 0.750 Thus, expression of either of the above sets of five genes could differentiate between breast cancer vs. no cancer, and breast cancer vs. all three cancers. Since the three cancers represent a very diverse group of cancers, it is likely that quantifying the mRNA levels of these five genes could distinguish between cancer and no cancer. Using the same methods as immediately above, we also identified 240 combinations of 5 biomarkers that distinguished breast cancer vs. no cancer controls that gave us an F-score of greater than or equal to 0.85. Those combinations are listed in Table 9, in order of F-score statistical significance, with the most significant listed first. For each combination of 5 biomarkers (BM1, BM2, BM3, BM4 and BM5), Table 9 provides values for precision (P), recall (R), F1 and area under the curve (AUC), as those variables are known in the art. Table 9. Combinations of 5 biomarkers that distinguish breast cancer vs. no breast cancer BM1 BM2 BM3 BM4 BM5 P R F1 AUC IL1B IL6 RGS2 SLC40A1 STK11 0.886 0.885 0.883 0.899 IL10 MMP13 NLRP1 SLC11A2 STK11 0.872 0.886 0.878 0.88 MMP13 NLRP1 SDK1 SLC11A2 STK11 0.913 0.843 0.871 0.874 CASP9 HAMP IL10 NLRP1 STK11 0.824 0.929 0.871 0.855 FKBP5 NLRP1 RGS2 SIRT1 STK11 0.835 0.914 0.87 0.836 CASP9 IL10 MMP13 NLRP1 STK11 0.881 0.871 0.869 0.879 CASP9 HAMP IL10 SLC22A4 STK11 0.83 0.914 0.868 0.853 IL10 MMP13 NLRP1 PPARG STK11 0.822 0.929 0.868 0.862 IL6 RGS2 SIRT1 SLC40A1 TGFB1 0.844 0.899 0.867 0.843 CRHR1 GCKR IL10 NFKB1 STK11 0.818 0.927 0.867 0.848 ABCA1 IL10 IL1B MUC1 STK11 0.806 0.943 0.866 0.801 CASP9 IL10 NLRP1 PAX8 STK11 0.844 0.9 0.866 0.868 IL1B IL6 RGS2 SIRT1 SLC40A1 0.811 0.942 0.866 0.877 CASP9 SIRT1 SKA2 SLC11A2 STK11 0.815 0.927 0.865 0.795 CCL27 RGS2 SDK1 SLC40A1 STK11 0.814 0.927 0.864 0.866 ABCA1 CASP9 HAMP IL10 STK11 0.809 0.929 0.864 0.835 HAMP IL10 NFKB1 SLC11A2 STK11 0.821 0.913 0.863 0.849 CASP9 CCL27 HAMP IL10 STK11 0.809 0.929 0.863 0.845 CASP9 GH1 IL10 NLRP1 STK11 0.823 0.914 0.863 0.86 IL10 NR3C1 SIRT1 STK11 TGFB1 0.8 0.942 0.863 0.811 IL10 IL1B MUC1 NFKB1 STK11 0.82 0.912 0.862 0.866 NLRP1 RGS2 SIRT1 SKA2 STK11 0.865 0.87 0.862 0.832 CASP9 HFE IL10 NLRP1 STK11 0.83 0.9 0.862 0.865 GH1 MUC1 NR3C1 SLC40A1 TNF 0.79 0.957 0.862 0.698 HFE MMP13 NLRP1 SLC11A2 STK11 0.875 0.856 0.862 0.872 CASP3 CCL27 RGS2 SDK1 SLC40A1 0.767 0.986 0.861 0.809 FGFR2 HFE IL10 NFKB1 STK11 0.828 0.899 0.861 0.846 CACNA1C NR3C1 SIRT1 SLC11A2 SLC40A1 0.796 0.942 0.861 0.724 NLRP1 NR3C1 SIRT1 SLC11A2 SLC40A1 0.797 0.942 0.861 0.742 IL10 MUC1 NFKB1 SLC40A1 STK11 0.798 0.942 0.861 0.844 IL1B SLC11A2 SLC40A1 STK11 VEGFA 0.776 0.971 0.861 0.772 IL1A NR3C1 SIRT1 SLC11A2 SLC40A1 0.796 0.942 0.861 0.741 IL18 NR3C1 SIRT1 SLC40A1 SMAD3 0.777 0.97 0.861 0.724 CRHR1 FKBP5 IL10 NFKB1 STK11 0.827 0.898 0.861 0.858 NLRP1 RGS2 SLC40A1 SMAD3 STK11 0.809 0.926 0.86 0.823 CASP9 CCL27 RGS2 SLC40A1 STK11 0.807 0.927 0.86 0.857 IL10 IL1A NFKB1 STK11 TGFB1 0.842 0.885 0.86 0.857 CRHR1 IL10 IL1B NFKB1 STK11 0.802 0.927 0.86 0.837 ABCA1 IL10 IL1B STK11 TGFB1 0.804 0.927 0.86 0.799 FKBP5 MUC1 NLRP1 SIRT1 STK11 0.809 0.929 0.86 0.811 CASP9 IL10 NFKB1 NLRP1 STK11 0.804 0.927 0.86 0.861 IL6 NR3C1 SIRT1 SLC11A2 SLC40A1 0.805 0.927 0.86 0.773 FKBP5 IL10 NFKB1 NR3C1 STK11 0.805 0.927 0.86 0.833 IL10 IL18 MUC1 NFKB1 STK11 0.793 0.941 0.86 0.837 CASP9 IL10 NFKB1 SIRT1 STK11 0.853 0.869 0.86 0.873 HAMP HFE IL10 NFKB1 STK11 0.839 0.885 0.859 0.876 IL10 NR3C1 PAX8 STK11 TGFB1 0.803 0.926 0.859 0.813 HAMP IL10 STK11 TGFB1 TNF 0.82 0.913 0.859 0.834 CASP9 NLRP1 SIRT1 SLC11A2 STK11 0.836 0.886 0.859 0.876 CASP9 SLC11A2 SLC40A1 STK11 VEGFA 0.801 0.926 0.859 0.844 CRHR1 IL10 MUC1 NFKB1 STK11 0.801 0.926 0.859 0.854 PAX8 SLC11A2 SLC40A1 STK11 VEGFA 0.783 0.956 0.859 0.814 CASP9 IL10 NFKB2 NLRP1 STK11 0.828 0.9 0.859 0.856 ABCA1 IL10 NR3C1 STK11 TGFB1 0.816 0.912 0.859 0.82 IL10 NFKB1 RGS2 SIRT1 STK11 0.882 0.841 0.859 0.873 GCKR IL10 MMP13 NFKB1 STK11 0.859 0.87 0.858 0.875 FKBP5 IL10 MUC1 NFKB1 STK11 0.802 0.926 0.858 0.86 IL10 MUC1 NFKB1 PAX8 STK11 0.802 0.926 0.858 0.856 CASP1 IL10 MUC1 NFKB1 STK11 0.802 0.926 0.858 0.851 CRHR1 IL10 NFKB1 PAX8 STK11 0.81 0.913 0.858 0.858 HAMP IL10 SMAD3 STK11 TGFB1 0.815 0.913 0.858 0.823 FKBP5 HAMP IL10 STK11 TGFB1 0.815 0.913 0.858 0.817 EDAR IL10 NFKB1 PAX8 STK11 0.811 0.913 0.858 0.85 CASP1 HAMP IL10 SLC11A2 STK11 0.801 0.927 0.858 0.84 IL10 MUC1 NR3C1 SDK1 SLC40A1 0.779 0.956 0.858 0.761 IL1B MUC1 NFKB2 SLC40A1 STK11 0.78 0.956 0.857 0.771 IL10 IL1A NFKB1 SLC11A2 STK11 0.81 0.913 0.857 0.839 CACNA1C HAMP IL10 STK11 TGFB1 0.814 0.913 0.857 0.821 CASP9 IL1B NLRP1 SIRT1 STK11 0.792 0.943 0.857 0.813 GCKR HAMP IL10 NFKB1 STK11 0.823 0.899 0.857 0.845 CASP9 HAMP IL10 NFKB1 STK11 0.811 0.913 0.857 0.877 CASP9 RGS2 SDK1 SLC40A1 STK11 0.813 0.914 0.857 0.832 CCL27 MUC1 RGS2 SDK1 SLC40A1 0.762 0.986 0.857 0.807 IL10 MMP13 NLRP1 RGS2 STK11 0.88 0.843 0.857 0.89 IL10 MUC1 NFKB1 STK11 TGFB1 0.81 0.913 0.857 0.856 HAMP IL10 MUC1 NLRP1 STK11 0.811 0.914 0.857 0.846 ABCA1 IL10 NFKB1 PAX8 STK11 0.802 0.927 0.857 0.844 CASP9 IL10 SDK1 SLC22A4 STK11 0.822 0.9 0.856 0.858 NR3C1 SIRT1 SLC11A2 SLC40A1 SMAD3 0.789 0.942 0.856 0.712 ABCA1 CCL27 MUC1 NR3C1 SLC40A1 0.781 0.957 0.856 0.739 IL18 MUC1 NLRP1 SDK1 STK11 0.831 0.9 0.856 0.869 ABCA1 IL10 MUC1 STK11 TGFB1 0.809 0.913 0.856 0.831 NR3C1 PAX8 SIRT1 SLC40A1 TNF 0.77 0.97 0.856 0.735 CASP9 CD274 RGS2 SLC40A1 STK11 0.801 0.927 0.856 0.837 IL10 MMP13 NFKB1 NFKB2 STK11 0.867 0.856 0.856 0.87 NR3C1 PAX8 SIRT1 SLC11A2 SLC40A1 0.786 0.942 0.855 0.743 HFE IL10 NFKB1 NLRP1 STK11 0.818 0.899 0.855 0.856 CACNA1C NR3C1 SIRT1 SLC40A1 SMAD3 0.769 0.97 0.855 0.73 HFE NLRP1 SLC11A2 STK11 VEGFA 0.82 0.9 0.855 0.853 CRHR1 HAMP IL10 STK11 TGFB1 0.825 0.899 0.855 0.817 CCL27 IL18 MUC1 SDK1 SLC40A1 0.769 0.97 0.855 0.812 IL10 MMP13 MUC1 NFKB1 STK11 0.818 0.898 0.855 0.873 FKBP5 NLRP1 SIRT1 SLC11A2 STK11 0.815 0.9 0.855 0.856 FKBP5 IL10 NFKB1 SMAD3 STK11 0.817 0.898 0.855 0.856 IL18 MUC1 PAX8 SLC40A1 STK11 0.797 0.927 0.855 0.804 IL18 MUC1 NFKB1 SLC40A1 STK11 0.797 0.927 0.855 0.792 IL18 MUC1 NFKB2 SLC40A1 STK11 0.797 0.927 0.855 0.781 CASP9 HAMP IL10 NFKB2 STK11 0.817 0.899 0.855 0.843 IL6 MUC1 NFKB1 NR3C1 SLC40A1 0.789 0.943 0.855 0.705 IL6 MUC1 NR3C1 SLC22A4 SLC40A1 0.789 0.943 0.855 0.703 MUC1 NLRP1 NR3C1 SLC40A1 TNF 0.789 0.943 0.855 0.687 FKBP5 IL10 IL1B NFKB1 STK11 0.811 0.913 0.855 0.847 CASP9 IL10 SLC22A4 STK11 TGFB1 0.844 0.87 0.855 0.861 IL10 NFKB2 SIRT1 SLC11A2 STK11 0.821 0.9 0.855 0.847 CASP9 CCL27 SIRT1 SLC11A2 STK11 0.787 0.943 0.855 0.803 CRHR1 MUC1 RGS2 SDK1 SLC40A1 0.765 0.971 0.855 0.762 CASP9 IL10 NLRP1 STK11 TGFB1 0.861 0.856 0.855 0.874 MUC1 NR3C1 PAX8 SLC40A1 STK11 0.785 0.941 0.855 0.782 MUC1 NFKB1 NR3C1 SLC40A1 STK11 0.785 0.941 0.855 0.765 MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.785 0.941 0.855 0.764 MUC1 NFKB1 NR3C1 RGS2 STK11 0.785 0.941 0.855 0.748 EPO MMP13 NLRP1 RGS2 STK11 0.871 0.856 0.855 0.887 IL1B MMP13 RGS2 SIRT1 SLC40A1 0.824 0.898 0.855 0.897 ABCA1 IL10 MMP13 NFKB1 STK11 0.838 0.885 0.855 0.882 NR3C1 PAX8 SIRT1 SLC40A1 SMAD3 0.767 0.969 0.855 0.727 CASP9 MMP13 NLRP1 SLC22A4 STK11 0.862 0.856 0.855 0.882 GH1 IL6 RGS2 SDK1 SLC40A1 0.75 1 0.855 0.783 IL6 RGS2 SDK1 SLC40A1 TNF 0.75 1 0.855 0.707 NLRP1 NR3C1 RGS2 SDK1 SLC40A1 0.75 1 0.855 0.692 GCKR HAMP IL10 NLRP1 STK11 0.794 0.929 0.854 0.808 ADAMTS4 IL1B NLRP1 SLC11A2 STK11 0.797 0.929 0.854 0.779 NLRP1 SDK1 SIRT1 SLC11A2 STK11 0.87 0.842 0.854 0.846 MUC1 NR3C1 SLC40A1 STK11 TNF 0.797 0.927 0.854 0.802 EDAR HAMP IL10 NLRP1 STK11 0.793 0.929 0.854 0.794 CASP9 IL10 NFKB1 SLC40A1 STK11 0.795 0.927 0.854 0.863 IL10 NFKB1 NR3C1 SDK1 STK11 0.795 0.927 0.854 0.828 IL10 MUC1 NFKB2 SDK1 STK11 0.816 0.899 0.854 0.844 CCL27 NLRP1 RGS2 SDK1 SIRT1 0.821 0.899 0.854 0.845 CCL27 IGF1 MUC1 NR3C1 SLC40A1 0.787 0.942 0.854 0.755 CCL27 IL18 MUC1 NLRP1 STK11 0.82 0.914 0.854 0.85 IL1B MUC1 NLRP1 SLC6A3 STK11 0.798 0.927 0.854 0.808 HAMP HFE IL10 STK11 TGFB1 0.836 0.885 0.854 0.822 CRHR1 HAMP IL10 NFKB1 STK11 0.805 0.913 0.854 0.859 CASP9 CRHR1 IL10 NFKB1 STK11 0.815 0.899 0.854 0.866 ADAMTS4 IL1B SLC11A2 SLC40A1 STK11 0.773 0.957 0.854 0.747 CCL27 NR3C1 SIRT1 SLC11A2 SLC40A1 0.794 0.927 0.854 0.794 MMP13 NLRP1 RGS2 SLC22A4 STK11 0.853 0.87 0.854 0.877 HFE IL10 MUC1 NFKB1 STK11 0.818 0.898 0.853 0.856 IL18 MUC1 NLRP1 SLC6A3 STK11 0.801 0.929 0.853 0.829 CCL27 RGS2 SIRT1 SLC22A4 TGFB1 0.801 0.927 0.853 0.819 IL10 NR3C1 SDK1 STK11 TGFB1 0.804 0.912 0.853 0.821 CASP1 IL10 NFKB1 SLC40A1 STK11 0.825 0.885 0.853 0.859 MMP13 NLRP1 SLC11A2 SLC22A4 STK11 0.863 0.857 0.853 0.887 MUC1 NLRP1 RGS2 SIRT1 STK11 0.822 0.9 0.853 0.827 IL10 MUC1 NFKB1 SLC22A4 STK11 0.794 0.926 0.853 0.848 CRHR1 IL10 SLC6A3 STK11 TGFB1 0.793 0.927 0.853 0.821 CACNA1C CASP9 IL10 NLRP1 STK11 0.819 0.9 0.853 0.873 HAMP IL10 NFKB1 PPARG STK11 0.829 0.885 0.853 0.843 NLRP1 SDK1 SLC11A2 STK11 VEGFA 0.828 0.886 0.853 0.882 IL10 IL18 NR3C1 STK11 TGFB1 0.792 0.926 0.853 0.805 CASP9 EPO IGF1 IL10 STK11 0.823 0.899 0.853 0.805 CCL27 RGS2 SIRT1 SLC40A1 TGFB1 0.808 0.912 0.853 0.847 CASP9 CCL27 IL10 SIRT1 STK11 0.832 0.885 0.853 0.802 CRHR1 IL10 NFKB1 SMAD3 STK11 0.825 0.884 0.853 0.838 CACNA1C HAMP IL10 NLRP1 STK11 0.783 0.943 0.853 0.827 IL10 NFKB1 PAX8 STK11 VEGFA 0.802 0.913 0.853 0.854 IL10 NLRP1 SKA2 SLC11A2 STK11 0.825 0.886 0.853 0.834 SDK1 SLC11A2 SLC40A1 STK11 VEGFA 0.771 0.956 0.853 0.853 IL10 IL6 MMP13 NFKB1 STK11 0.851 0.87 0.853 0.867 CCL27 NLRP1 RGS2 SIRT1 TGFB1 0.828 0.9 0.853 0.831 IGF1 RGS2 SLC40A1 STK11 TNF 0.79 0.942 0.852 0.81 FKBP5 IL6 MUC1 NFKB1 SLC40A1 0.754 0.986 0.852 0.761 CASP9 IL1B NLRP1 STK11 TGFB1 0.786 0.943 0.852 0.786 IL10 IL1A MUC1 NFKB1 STK11 0.791 0.926 0.852 0.868 FGFR2 HAMP IL10 NLRP1 STK11 0.781 0.943 0.852 0.831 HAMP IL10 MUC1 NFKB1 STK11 0.825 0.884 0.852 0.887 CCL27 MUC1 NLRP1 SDK1 STK11 0.846 0.87 0.852 0.878 IL10 NFKB2 SLC11A2 STK11 VEGFA 0.824 0.886 0.852 0.845 HFE MMP13 SDK1 SLC40A1 STK11 0.828 0.884 0.852 0.85 ABCA1 IL10 PPARG STK11 TGFB1 0.845 0.87 0.852 0.818 NR3C1 PAX8 SIRT1 STK11 TNF 0.786 0.942 0.852 0.791 CCL27 HAMP IL10 NFKB1 STK11 0.814 0.899 0.852 0.848 CD274 HAMP IL10 NFKB1 STK11 0.814 0.899 0.852 0.845 HAMP IL10 SLC22A4 SMAD3 STK11 0.799 0.913 0.852 0.84 MMP13 NLRP1 RGS2 SIRT1 STK11 0.871 0.842 0.852 0.879 CASP9 HAMP IL10 SLC40A1 STK11 0.802 0.913 0.852 0.857 IL1A NR3C1 RGS2 SLC22A4 TGFB1 0.771 0.956 0.852 0.744 MMP13 MUC1 NLRP1 SDK1 STK11 0.881 0.842 0.852 0.891 ABCA1 IL10 MUC1 NFKB1 STK11 0.789 0.926 0.852 0.848 IL10 MUC1 NFKB2 SLC22A4 STK11 0.79 0.929 0.852 0.845 CASP9 EDAR IL10 NLRP1 STK11 0.829 0.886 0.852 0.866 FGFR2 IL10 MMP13 NFKB1 STK11 0.844 0.869 0.852 0.877 CASP1 IL10 MUC1 NR3C1 STK11 0.768 0.956 0.852 0.759 CCL27 IL10 RGS2 SLC40A1 TGFB1 0.776 0.957 0.852 0.796 HAMP IL10 IL18 STK11 TGFB1 0.802 0.913 0.851 0.808 CACNA1C IL10 NR3C1 STK11 TGFB1 0.801 0.912 0.851 0.826 FKBP5 IL10 NR3C1 STK11 TGFB1 0.801 0.912 0.851 0.823 IL10 NLRP3 NR3C1 STK11 TGFB1 0.801 0.912 0.851 0.821 CASP1 IL10 NR3C1 STK11 TGFB1 0.801 0.912 0.851 0.821 EDAR IL10 NR3C1 STK11 TGFB1 0.801 0.912 0.851 0.819 FKBP5 HAMP IL10 NFKB1 STK11 0.813 0.899 0.851 0.866 IL1B IL6 RGS2 SDK1 SLC40A1 0.769 0.956 0.851 0.833 HFE NLRP1 SIRT1 SLC11A2 STK11 0.837 0.87 0.851 0.838 CASP1 CASP9 HAMP IL10 STK11 0.802 0.913 0.851 0.859 RGS2 SIRT1 SLC22A4 SMAD3 STK11 0.832 0.884 0.851 0.814 GCKR HFE IL10 NFKB1 STK11 0.835 0.87 0.851 0.849 NLRP1 NR3C1 RGS2 STK11 TGFB1 0.803 0.912 0.851 0.822 HFE IL10 NFKB1 SLC6A3 STK11 0.812 0.899 0.851 0.868 ABCA1 EDAR IL10 MUC1 STK11 0.768 0.957 0.851 0.805 MUC1 NLRP1 SDK1 STK11 TGFB1 0.843 0.871 0.851 0.865 CASP9 IL10 NFKB1 PPARG STK11 0.799 0.913 0.851 0.839 HAMP IL10 MUC1 SLC22A4 STK11 0.799 0.914 0.851 0.846 IL10 NR3C1 PPARG STK11 TGFB1 0.814 0.898 0.851 0.797 CRHR1 IL1B MMP13 RGS2 SLC40A1 0.801 0.912 0.851 0.872 CCL27 IL1B SLC40A1 STK11 TGFB1 0.796 0.927 0.851 0.78 IL10 RGS2 SLC40A1 SLC6A3 STK11 0.8 0.913 0.851 0.852 FKBP5 HAMP MUC1 NLRP1 STK11 0.783 0.943 0.851 0.836 IL18 MUC1 NFKB1 NR3C1 STK11 0.769 0.955 0.851 0.753 CASP9 IL1B NLRP1 SDK1 STK11 0.794 0.929 0.851 0.805 IL10 MMP13 NFKB1 STK11 TNF 0.848 0.87 0.851 0.866 EPO NR3C1 PAX8 SIRT1 TGFB1 0.779 0.941 0.851 0.793 GH1 NR3C1 PAX8 SIRT1 TGFB1 0.779 0.941 0.851 0.783 CRHR1 NR3C1 PAX8 SIRT1 TGFB1 0.779 0.941 0.851 0.783 NR3C1 PAX8 SIRT1 SLC22A4 TGFB1 0.779 0.941 0.851 0.782 NR3C1 PAX8 SIRT1 SLC40A1 TGFB1 0.779 0.941 0.851 0.775 GH1 IL10 MUC1 NLRP1 STK11 0.802 0.914 0.851 0.856 IL6 MUC1 NFKB2 SLC40A1 STK11 0.803 0.913 0.851 0.82 CASP9 HAMP IL10 RGS2 STK11 0.825 0.885 0.851 0.829 HFE2 IL1B SLC11A2 SLC40A1 STK11 0.761 0.971 0.851 0.751 CD274 CRHR1 IL10 MMP13 MUC1 0.82 0.899 0.851 0.802 HFE IL10 MMP13 NFKB1 SIRT1 0.884 0.825 0.85 0.866 FKBP5 RGS2 SDK1 SLC40A1 STK11 0.8 0.912 0.85 0.845 CASP1 MUC1 NR3C1 SKA2 STK11 0.768 0.955 0.85 0.754 NLRP1 NR3C1 SIRT1 SLC40A1 SMAD3 0.762 0.97 0.85 0.736 FGFR2 NR3C1 SIRT1 SLC40A1 SMAD3 0.762 0.97 0.85 0.715 IL10 MUC1 NFKB1 SLC6A3 STK11 0.798 0.912 0.85 0.873 CASP9 MUC1 NLRP1 STK11 TGFB1 0.799 0.914 0.85 0.816 HAMP IL10 NFKB1 STK11 TGFB1 0.814 0.899 0.85 0.851 NLRP1 RGS2 SIRT1 SLC40A1 TGFB1 0.782 0.942 0.85 0.789 IL10 IL1A MUC1 NFKB2 STK11 0.81 0.899 0.85 0.826 HAMP IL10 NFKB1 NR3C1 STK11 0.811 0.898 0.85 0.835 CASP9 IL10 NFKB1 SKA2 STK11 0.85 0.856 0.85 0.85 IL10 IL1B NFKB1 PAX8 STK11 0.789 0.927 0.85 0.841 MUC1 NR3C1 SDK1 SLC40A1 STK11 0.78 0.942 0.85 0.799 IL6 PAX8 RGS2 SDK1 SLC40A1 0.744 1 0.85 0.771 GCKR IL10 NR3C1 SLC40A1 TNF 0.744 1 0.85 0.657 CACNA1C CRHR1 IL10 NFKB1 STK11 0.808 0.899 0.85 0.849 IL10 MUC1 RGS2 SDK1 SLC40A1 0.759 0.971 0.85 0.772 NR3C1 SIRT1 SLC11A2 SLC40A1 VEGFA 0.779 0.942 0.85 0.725 HAMP NR3C1 SIRT1 SLC11A2 SLC40A1 0.779 0.942 0.85 0.719 Thus, expression of any of the above sets of five genes could differentiate between breast cancer vs. no cancer. Using the same methods as immediately above, we also identified 3285 combinations of 6 biomarkers that distinguished breast cancer vs. no cancer controls that gave us an F-score of greater than or equal to 0.85. Those combinations are listed in Table 10, in order of F-score statistical significance, with the most significant listed first. For each combination of 6 biomarkers (BM1, BM2, BM3, BM4. BM5 and BM6), Table 9 provides values for precision (P), recall (R), F1 and area under the curve (AUC), as those variables are known in the art. Table 10. Combinations of 6 biomarkers that distinguish breast cancer vs. no breast cancer BM1 BM2 BM3 BM4 BM5 BM6 P R F1 AUC CASP9 IL1B IL6 RGS2 SLC40A1 STK11 0.892 0.913 0.9 0.897 HAMP IL10 RGS2 SLC22A4 STK11 TGFB1 0.888 0.902 0.892 0.849 CASP9 MMP13 NLRP1 SIRT1 SLC11A2 STK11 0.886 0.9 0.891 0.885 CASP9 IL10 MMP13 NLRP1 STK11 VEGFA 0.91 0.886 0.89 0.876 CASP9 MMP13 NLRP1 RGS2 SDK1 STK11 0.925 0.87 0.889 0.887 HFE IL10 MMP13 NFKB1 SIRT1 STK11 0.912 0.87 0.888 0.894 CASP9 HAMP IL10 NFKB1 SIRT1 STK11 0.863 0.915 0.888 0.883 CRHR1 IL10 MUC1 NFKB1 SLC40A1 STK11 0.827 0.956 0.885 0.856 CACNA1C HFE IL10 NFKB1 SLC6A3 STK11 0.874 0.9 0.885 0.874 CASP9 CCL27 IL10 RGS2 SLC40A1 STK11 0.847 0.928 0.884 0.851 HAMP IL10 NFKB2 SLC11A2 STK11 VEGFA 0.838 0.943 0.884 0.854 CRHR1 HAMP IL10 MUC1 NFKB1 STK11 0.846 0.929 0.884 0.884 CASP9 IL10 NFKB1 NLRP3 SIRT1 STK11 0.885 0.886 0.883 0.878 CASP9 FGFR2 IL10 NFKB1 SIRT1 STK11 0.886 0.886 0.883 0.869 CASP9 CD274 IL10 MMP13 NLRP1 STK11 0.897 0.888 0.883 0.876 CASP9 IL10 KRT1 NFKB1 STK11 TGFB1 0.847 0.929 0.883 0.86 HFE IL10 NFKB1 PAX8 SLC6A3 STK11 0.857 0.913 0.882 0.883 ADAMTS4 CASP9 IL10 MMP13 NLRP1 STK11 0.907 0.872 0.882 0.876 CASP9 IL10 MMP13 NLRP1 SDK1 STK11 0.908 0.872 0.882 0.863 CD274 IL10 MUC1 NFKB2 PAX8 STK11 0.809 0.971 0.882 0.841 CD274 HFE IL10 NFKB1 SLC6A3 STK11 0.857 0.914 0.881 0.883 HAMP HFE IL10 NFKB1 NLRP3 STK11 0.854 0.913 0.881 0.856 CASP9 MMP13 NLRP1 SLC11A2 SLC22A4 STK11 0.9 0.87 0.881 0.888 CASP9 IL1B MMP13 RGS2 SLC40A1 STK11 0.854 0.913 0.881 0.898 HAMP IL10 NFKB1 SLC11A2 SLC6A3 STK11 0.851 0.914 0.88 0.858 HFE IL10 IL6 NFKB1 SLC6A3 STK11 0.853 0.913 0.88 0.886 IL10 MMP13 NFKB1 NLRP3 STK11 TGFB1 0.88 0.885 0.88 0.861 CRHR1 IL10 IL1B MUC1 NFKB1 STK11 0.827 0.943 0.879 0.858 CASP9 CRHR1 IL10 NFKB1 SIRT1 STK11 0.863 0.902 0.879 0.876 CASP9 IL10 NFKB1 SIRT1 STK11 TGFB1 0.863 0.902 0.879 0.878 FKBP5 HAMP HFE IL10 NFKB1 STK11 0.862 0.898 0.879 0.873 CD274 HAMP IL10 MUC1 NFKB1 STK11 0.826 0.942 0.879 0.875 KRT1 MMP13 MUC1 NLRP1 SDK1 STK11 0.914 0.855 0.879 0.874 HAMP IL10 KRT1 NFKB1 SLC11A2 STK11 0.824 0.943 0.878 0.833 CRHR1 IL10 MUC1 NFKB1 STK11 VEGFA 0.826 0.942 0.878 0.865 IL10 NLRP1 NR3C1 SIRT1 STK11 TNF 0.804 0.971 0.878 0.829 CASP9 CCL27 RGS2 SLC22A4 SLC40A1 STK11 0.847 0.913 0.878 0.848 ABCA1 IL10 MUC1 NFKB2 STK11 TGFB1 0.824 0.943 0.878 0.835 CASP9 IL10 NFKB1 SIRT1 SLC40A1 STK11 0.872 0.888 0.877 0.88 CASP9 IL10 NFKB1 SIRT1 STK11 VEGFA 0.872 0.886 0.877 0.878 CASP9 HFE IL10 IL6 NFKB1 STK11 0.871 0.885 0.877 0.856 CACNA1C IL6 RGS2 SLC40A1 STK11 TGFB1 0.873 0.885 0.877 0.883 HAMP IL10 NFKB2 SIRT1 SLC11A2 STK11 0.84 0.931 0.877 0.83 IL10 IL6 NFKB1 NLRP1 SLC11A2 STK11 0.835 0.928 0.877 0.839 GCKR HAMP IL10 MUC1 NFKB1 STK11 0.835 0.927 0.877 0.869 CASP9 HAMP IL10 RGS2 SLC40A1 STK11 0.847 0.914 0.877 0.87 CASP9 IGF1 IL10 NFKB1 SIRT1 STK11 0.873 0.886 0.877 0.866 CASP9 IL10 KRT83 NFKB1 SIRT1 STK11 0.871 0.886 0.877 0.87 IL1B IL6 RGS2 SLC40A1 STK11 TGFB1 0.886 0.871 0.877 0.898 CD274 HAMP IL10 NFKB1 SLC11A2 STK11 0.834 0.928 0.877 0.84 ADAMTS4 CRHR1 IL10 MUC1 NFKB1 STK11 0.832 0.927 0.876 0.872 CASP9 IL10 MMP13 NLRP1 SMAD3 STK11 0.897 0.871 0.876 0.867 HAMP IL10 MUC1 NFKB1 PAX8 STK11 0.844 0.913 0.876 0.868 CASP9 FKBP5 RGS2 SLC40A1 SLC6A3 STK11 0.821 0.943 0.876 0.839 CASP9 CCL27 CD274 RGS2 SLC40A1 STK11 0.822 0.942 0.876 0.839 CASP9 MMP13 NLRP1 NLRP3 SLC11A2 STK11 0.873 0.886 0.876 0.864 CASP9 IL10 KRT1 MMP13 NLRP1 STK11 0.889 0.872 0.876 0.867 ADAMTS4 IL10 NFKB1 NLRP1 SLC11A2 STK11 0.843 0.914 0.875 0.838 CASP3 EPO IL10 NFKB1 SLC11A2 STK11 0.845 0.914 0.875 0.842 HAMP IL10 NFKB1 NFKB2 SLC11A2 STK11 0.845 0.914 0.875 0.839 CASP9 HAMP IL10 NFKB1 SLC6A3 STK11 0.842 0.914 0.875 0.876 CASP9 CD274 IL10 NFKB1 SIRT1 STK11 0.884 0.871 0.875 0.876 HFE IL10 IL6 MMP13 NFKB1 STK11 0.883 0.87 0.875 0.884 HAMP IL10 NLRP1 SLC11A2 STK11 TGFB1 0.831 0.929 0.875 0.863 CASP9 IL10 KRT83 MMP13 NLRP1 STK11 0.894 0.871 0.875 0.857 CASP9 IL10 MMP13 RGS2 SLC40A1 STK11 0.857 0.9 0.875 0.877 CCL27 IL6 RGS2 SLC40A1 STK11 TGFB1 0.905 0.857 0.875 0.895 CRHR1 IL10 MUC1 NFKB1 SKA2 STK11 0.842 0.913 0.875 0.873 FKBP5 HFE IL10 NFKB1 SLC6A3 STK11 0.856 0.899 0.875 0.887 CASP9 CCL27 HAMP IL10 RGS2 STK11 0.841 0.915 0.875 0.857 HAMP IL10 MUC1 NFKB1 SLC40A1 STK11 0.808 0.957 0.875 0.851 GH1 HFE IL10 NFKB1 SLC6A3 STK11 0.845 0.914 0.875 0.874 HAMP HFE IL10 NFKB1 SLC6A3 STK11 0.845 0.914 0.875 0.876 CASP9 HAMP IL10 MUC1 NFKB1 STK11 0.842 0.914 0.875 0.876 IL6 MMP13 RGS2 SLC40A1 STK11 TGFB1 0.899 0.857 0.875 0.889 EPO HAMP HFE IL10 NFKB1 STK11 0.842 0.913 0.875 0.854 CCL27 MMP13 MUC1 NLRP1 SDK1 STK11 0.89 0.869 0.874 0.876 CASP9 MMP13 NLRP1 SDK1 SLC11A2 STK11 0.9 0.856 0.874 0.882 ADAMTS4 HFE IL10 NFKB1 SLC6A3 STK11 0.856 0.9 0.874 0.864 HAMP HFE IL10 NFKB1 PAX8 STK11 0.854 0.899 0.874 0.871 EPO HFE IL10 NFKB1 SLC6A3 STK11 0.843 0.914 0.874 0.874 HFE IL10 NFKB1 SLC22A4 SLC6A3 STK11 0.845 0.914 0.874 0.853 IL10 KRT1 NFKB2 SLC11A2 STK11 TGFB1 0.855 0.902 0.874 0.827 ABCA1 GH1 IL10 MUC1 NFKB2 STK11 0.807 0.956 0.874 0.807 CACNA1C GCKR IL10 NFKB1 PAX8 STK11 0.845 0.913 0.873 0.853 FKBP5 HFE IL10 NFKB1 STK11 VEGFA 0.852 0.898 0.873 0.87 ABCA1 CASP9 HFE MMP13 SLC40A1 STK11 0.851 0.899 0.873 0.854 ABCA1 CASP9 CCL27 RGS2 SLC40A1 STK11 0.827 0.928 0.873 0.853 CASP9 CCL27 HAMP RGS2 SLC40A1 STK11 0.827 0.928 0.873 0.844 CCL27 HAMP IL10 MUC1 STK11 TGFB1 0.836 0.928 0.873 0.79 HFE KRT83 NLRP1 SIRT1 SLC11A2 STK11 0.853 0.899 0.873 0.834 CASP9 MMP13 NLRP1 SLC22A4 STK11 TGFB1 0.906 0.856 0.873 0.866 CASP9 HFE IL6 SLC6A3 STK11 TGFB1 0.839 0.915 0.873 0.843 HAMP IL10 MUC1 NFKB2 SLC40A1 STK11 0.816 0.943 0.873 0.831 FKBP5 IL10 MMP13 NFKB1 SIRT1 STK11 0.905 0.857 0.873 0.878 HAMP HFE IL10 MUC1 NFKB1 STK11 0.853 0.896 0.873 0.886 HAMP IL10 KRT1 NLRP1 SLC11A2 STK11 0.815 0.943 0.873 0.828 CASP1 HAMP IL10 MUC1 NFKB1 STK11 0.816 0.942 0.873 0.862 HFE IL10 MUC1 NFKB1 SLC6A3 STK11 0.849 0.898 0.872 0.887 CASP3 FGFR2 IL10 MUC1 NFKB1 STK11 0.815 0.942 0.872 0.864 ABCA1 CACNA1C IL10 MUC1 NFKB2 STK11 0.814 0.942 0.872 0.801 CASP9 HFE IL10 NFKB1 STK11 TGFB1 0.862 0.886 0.872 0.856 CASP9 HFE IL10 NFKB1 SMAD3 STK11 0.862 0.886 0.872 0.863 CASP9 EDAR IL10 NFKB1 SIRT1 STK11 0.861 0.886 0.872 0.872 HAMP HFE IL10 NFKB1 STK11 TNF 0.862 0.885 0.872 0.856 CACNA1C CASP9 HFE MMP13 SLC40A1 STK11 0.871 0.886 0.872 0.864 MMP13 NLRP1 RGS2 SDK1 SIRT1 TNF 0.852 0.898 0.872 0.869 CASP9 EPO NLRP1 RGS2 SDK1 STK11 0.842 0.914 0.872 0.869 CCL27 KRT83 RGS2 SIRT1 SLC40A1 TGFB1 0.815 0.941 0.872 0.846 HAMP HFE IL10 IL6 NFKB1 STK11 0.85 0.898 0.872 0.856 CASP9 HAMP IL10 NLRP1 SLC11A2 STK11 0.827 0.928 0.872 0.892 HFE IL6 NFKB1 PAX8 STK11 VEGFA 0.851 0.896 0.872 0.841 ADAMTS4 HAMP IL10 NFKB2 SLC11A2 STK11 0.825 0.929 0.872 0.854 HAMP IL10 IL1A NFKB1 SLC6A3 STK11 0.824 0.928 0.871 0.841 CASP9 IL18 MMP13 NLRP1 SLC22A4 STK11 0.865 0.886 0.871 0.846 MMP13 NLRP1 RGS2 SDK1 SMAD3 STK11 0.919 0.84 0.871 0.866 IL6 RGS2 SLC22A4 SLC40A1 STK11 TGFB1 0.876 0.871 0.871 0.878 HFE IL10 NFKB1 RGS2 SLC6A3 STK11 0.864 0.885 0.871 0.874 CASP9 IL10 KRT1 NFKB1 SIRT1 STK11 0.86 0.886 0.871 0.862 HAMP HFE IL10 NFKB1 SMAD3 STK11 0.861 0.884 0.871 0.85 HAMP IL10 PAX8 STK11 TGFB1 TNF 0.859 0.902 0.871 0.82 CASP9 CCL27 HFE MMP13 SLC40A1 STK11 0.861 0.886 0.871 0.838 IL10 MMP13 NLRP1 SLC11A2 SMAD3 STK11 0.864 0.885 0.871 0.873 ADAMTS4 HAMP HFE IL10 NFKB1 STK11 0.861 0.884 0.871 0.853 HAMP HFE IL10 NFKB1 STK11 VEGFA 0.861 0.884 0.871 0.86 ABCA1 GH1 IL10 MUC1 NFKB1 STK11 0.812 0.941 0.871 0.831 CD274 HAMP IL10 NFKB1 SLC6A3 STK11 0.824 0.928 0.871 0.854 IL10 NFKB1 SKA2 SLC11A2 STK11 TGFB1 0.883 0.872 0.871 0.856 CASP3 CRHR1 IL10 MUC1 NFKB1 STK11 0.812 0.942 0.871 0.871 CASP9 CCL27 PAX8 RGS2 SLC40A1 STK11 0.834 0.913 0.871 0.839 HAMP IL10 NLRP1 PAX8 SLC11A2 STK11 0.824 0.928 0.871 0.835 HFE RGS2 SDK1 SKA2 SLC40A1 VEGFA 0.776 1 0.871 0.786 CCL27 MUC1 NLRP1 SDK1 STK11 TGFB1 0.861 0.885 0.871 0.848 CASP9 IL10 MUC1 NFKB1 STK11 VEGFA 0.823 0.927 0.871 0.846 HFE IL10 IL6 NFKB1 STK11 VEGFA 0.859 0.884 0.871 0.864 IL10 NFKB1 NLRP1 NLRP3 SLC11A2 STK11 0.86 0.885 0.871 0.867 IL10 MMP13 NFKB1 SLC6A3 STK11 TNF 0.835 0.913 0.871 0.852 CASP1 FGFR2 IL10 MMP13 NFKB1 STK11 0.875 0.871 0.871 0.854 HAMP HFE2 IL10 NLRP1 SLC11A2 STK11 0.824 0.928 0.871 0.836 HAMP IL10 MUC1 NFKB1 STK11 TGFB1 0.823 0.929 0.871 0.876 HAMP IL10 NFKB1 NLRP3 PAX8 STK11 0.821 0.928 0.871 0.858 IL10 NFKB1 NLRP1 SLC11A2 STK11 VEGFA 0.823 0.928 0.87 0.859 CASP9 EDAR GH1 RGS2 SLC40A1 STK11 0.813 0.942 0.87 0.82 CASP9 EDAR RGS2 SLC22A4 SLC40A1 STK11 0.813 0.942 0.87 0.825 EPO HAMP IL10 NLRP1 SLC11A2 STK11 0.822 0.928 0.87 0.849 HAMP HFE IL10 MUC1 NFKB2 STK11 0.824 0.928 0.87 0.849 CRHR1 IL1B IL6 RGS2 SIRT1 SLC40A1 0.832 0.914 0.87 0.843 CD274 HAMP IL10 NLRP1 SLC11A2 STK11 0.824 0.928 0.87 0.849 ADAMTS4 CASP9 HFE MMP13 SLC40A1 STK11 0.859 0.886 0.87 0.852 ABCA1 IL10 MUC1 NFKB2 SIRT1 STK11 0.789 0.971 0.87 0.803 IL10 IL1B MUC1 NFKB1 SKA2 STK11 0.822 0.927 0.87 0.847 CASP9 HFE IL10 NFKB1 SIRT1 STK11 0.873 0.871 0.87 0.883 CCL27 HFE IL10 NFKB1 SLC6A3 STK11 0.87 0.871 0.87 0.869 CASP9 EPO GH1 RGS2 SLC40A1 STK11 0.812 0.942 0.87 0.836 CCL27 HFE IL6 SLC11A2 SLC40A1 STK11 0.835 0.914 0.87 0.861 CASP1 IL10 MUC1 NFKB1 SKA2 STK11 0.822 0.927 0.87 0.864 CASP9 CCL27 HAMP IL10 SLC11A2 STK11 0.822 0.931 0.87 0.853 GCKR IL10 IL1A MUC1 NFKB1 STK11 0.821 0.927 0.87 0.856 HFE IL6 RGS2 SLC40A1 STK11 TGFB1 0.894 0.859 0.87 0.888 CASP9 CCL27 EDAR SIRT1 SLC11A2 STK11 0.845 0.915 0.87 0.811 CASP9 IL10 MMP13 NLRP1 SLC22A4 STK11 0.884 0.871 0.87 0.881 CASP9 HAMP IL10 SLC11A2 SLC22A4 STK11 0.822 0.929 0.87 0.88 CACNA1C IL10 MUC1 NFKB2 PAX8 STK11 0.821 0.926 0.87 0.842 IL10 KRT83 MUC1 NFKB2 PAX8 STK11 0.821 0.926 0.87 0.814 CASP9 FGFR2 RGS2 SLC22A4 SLC40A1 STK11 0.811 0.942 0.87 0.83 ABCA1 HFE IL6 MMP13 MUC1 STK11 0.821 0.927 0.87 0.84 CASP9 IL10 MMP13 NLRP1 SLC11A2 STK11 0.863 0.886 0.87 0.881 MMP13 NLRP1 RGS2 SDK1 SLC11A2 STK11 0.917 0.84 0.87 0.889 CASP9 GCKR IL10 NFKB1 SIRT1 STK11 0.87 0.871 0.87 0.876 CASP9 IL10 NFKB1 SIRT1 SLC22A4 STK11 0.871 0.872 0.87 0.883 EPO HFE MMP13 NLRP1 SLC11A2 STK11 0.873 0.869 0.869 0.846 CASP3 CD274 HFE MMP13 NR3C1 STK11 0.833 0.913 0.869 0.802 FKBP5 HAMP IL10 NFKB1 SLC6A3 STK11 0.832 0.914 0.869 0.858 IL10 IL6 NFKB1 SLC11A2 SLC22A4 STK11 0.833 0.914 0.869 0.836 CASP3 CASP9 HAMP IL10 NFKB1 STK11 0.831 0.914 0.869 0.874 CASP9 MMP13 NLRP1 NLRP3 SLC22A4 STK11 0.868 0.886 0.869 0.863 CD274 HFE IL10 MUC1 NFKB1 STK11 0.832 0.913 0.869 0.869 CRHR1 IL10 NFKB1 SLC11A2 STK11 VEGFA 0.834 0.914 0.869 0.847 HFE IL10 NFKB1 NFKB2 SLC6A3 STK11 0.837 0.914 0.869 0.869 CRHR1 HAMP IL10 NFKB1 SLC11A2 STK11 0.832 0.913 0.869 0.835 CASP3 GCKR IL10 MUC1 NFKB1 STK11 0.798 0.957 0.869 0.858 HAMP IL10 MMP13 NFKB1 SLC6A3 STK11 0.843 0.899 0.869 0.87 IL10 MUC1 NFKB1 PAX8 SLC40A1 STK11 0.799 0.957 0.869 0.838 CCL27 IL6 NLRP1 RGS2 SIRT1 TNF 0.864 0.883 0.869 0.87 CCL27 RGS2 SIRT1 SLC40A1 TGFB1 TNF 0.798 0.956 0.869 0.843 CASP9 HAMP MMP13 NLRP1 SLC22A4 STK11 0.875 0.871 0.869 0.862 GCKR IL10 MMP13 NFKB1 RGS2 STK11 0.891 0.856 0.869 0.879 ABCA1 IL10 IL18 MUC1 NFKB1 STK11 0.799 0.957 0.869 0.824 IL10 MMP13 NFKB1 RGS2 STK11 VEGFA 0.885 0.856 0.869 0.879 CCL27 IL1B RGS2 SDK1 SLC40A1 TGFB1 0.8 0.957 0.869 0.843 EPO IL10 NFKB1 NLRP3 SLC11A2 STK11 0.833 0.914 0.869 0.824 HFE NLRP1 SIRT1 SLC11A2 STK11 VEGFA 0.832 0.913 0.869 0.85 CASP9 MUC1 NR3C1 SLC40A1 STK11 TNF 0.812 0.943 0.869 0.771 ADAMTS4 CASP9 IL10 NFKB1 SIRT1 STK11 0.871 0.872 0.869 0.864 CACNA1C CASP9 IL10 NFKB1 SIRT1 STK11 0.871 0.872 0.869 0.873 CASP9 FKBP5 IL10 NFKB1 SIRT1 STK11 0.871 0.872 0.869 0.876 HAMP HFE IL10 NLRP1 SLC11A2 STK11 0.832 0.913 0.869 0.854 GCKR IL10 MMP13 NFKB1 SKA2 STK11 0.885 0.857 0.869 0.853 CASP1 HFE IL10 NFKB1 SLC6A3 STK11 0.834 0.914 0.869 0.869 ABCA1 HFE IL10 MUC1 NFKB1 STK11 0.831 0.912 0.869 0.852 CCL27 HAMP IL10 MUC1 NFKB1 STK11 0.831 0.912 0.869 0.878 CASP9 HFE IL10 NFKB1 STK11 VEGFA 0.843 0.9 0.869 0.849 CD274 HAMP IL10 NFKB1 NLRP3 STK11 0.831 0.914 0.869 0.844 EPO HAMP IL10 NFKB1 NLRP3 STK11 0.831 0.914 0.869 0.845 CASP9 IL10 NFKB1 PAX8 SIRT1 STK11 0.874 0.872 0.869 0.873 CASP9 CCL27 IL6 RGS2 SLC40A1 STK11 0.85 0.899 0.869 0.847 HFE IL10 MMP13 NLRP1 SLC11A2 STK11 0.872 0.871 0.869 0.855 IL1B IL6 RGS2 SDK1 SLC40A1 SLC6A3 0.796 0.957 0.869 0.822 CACNA1C HAMP IL10 NFKB1 PAX8 STK11 0.841 0.899 0.869 0.849 HAMP IL10 MUC1 NFKB2 SIRT1 STK11 0.798 0.957 0.868 0.833 CCL27 FKBP5 MUC1 NLRP1 SDK1 STK11 0.878 0.869 0.868 0.848 IL10 MUC1 NFKB1 SLC40A1 STK11 VEGFA 0.798 0.956 0.868 0.842 CD274 FKBP5 GCKR IL10 NFKB1 STK11 0.837 0.913 0.868 0.858 CASP9 CCL27 NLRP1 SDK1 SLC11A2 STK11 0.846 0.899 0.868 0.853 HAMP IGF1 IL10 NLRP1 SLC11A2 STK11 0.831 0.913 0.868 0.841 CASP9 IL10 NFKB1 PPARG STK11 TGFB1 0.843 0.9 0.868 0.86 HAMP IL10 MUC1 NFKB2 SLC6A3 STK11 0.83 0.913 0.868 0.856 CCL27 IL18 RGS2 SIRT1 SLC40A1 TGFB1 0.798 0.955 0.868 0.832 HAMP IL10 MMP13 MUC1 NFKB1 STK11 0.843 0.899 0.868 0.883 HFE IL6 MMP13 NFKB1 STK11 TNF 0.875 0.867 0.868 0.865 CD274 IL10 NFKB1 PPARG STK11 TGFB1 0.843 0.902 0.868 0.835 CASP9 CCL27 FKBP5 HAMP IL10 STK11 0.83 0.915 0.868 0.853 CRHR1 IL10 MUC1 NFKB1 PAX8 STK11 0.831 0.913 0.868 0.869 CRHR1 IL10 MMP13 NFKB1 SIRT1 TNF 0.869 0.872 0.868 0.863 CCL27 IL10 MMP13 NFKB1 SLC6A3 STK11 0.841 0.899 0.868 0.87 ABCA1 CASP9 EDAR RGS2 SLC40A1 STK11 0.819 0.928 0.868 0.823 CASP9 CCL27 GH1 RGS2 SLC40A1 STK11 0.819 0.928 0.868 0.846 CASP9 NFKB2 RGS2 SLC22A4 SLC40A1 STK11 0.819 0.928 0.868 0.834 CRHR1 IL10 MMP13 NFKB1 SIRT1 SLC40A1 0.871 0.872 0.868 0.872 CCL27 HAMP IL10 MUC1 SLC22A4 STK11 0.829 0.913 0.868 0.84 CASP9 EPO RGS2 SLC11A2 SLC40A1 STK11 0.82 0.928 0.868 0.841 CASP9 EPO RGS2 SLC22A4 SLC40A1 STK11 0.82 0.928 0.868 0.844 HAMP IL10 MMP13 NFKB1 RGS2 STK11 0.855 0.884 0.868 0.863 CASP9 CD274 IL10 NFKB1 STK11 TGFB1 0.848 0.902 0.868 0.864 CASP9 FKBP5 MMP13 NLRP1 NLRP3 STK11 0.871 0.871 0.868 0.854 IL1B IL6 RGS2 SLC40A1 SMAD3 STK11 0.887 0.855 0.868 0.885 CASP9 HAMP IL10 NFKB1 STK11 TGFB1 0.84 0.9 0.868 0.879 CASP9 MMP13 NLRP1 SLC6A3 STK11 TGFB1 0.87 0.872 0.868 0.845 CASP1 IL10 NFKB1 NLRP1 SIRT1 STK11 0.808 0.942 0.868 0.843 HAMP IL10 NLRP1 SLC11A2 SMAD3 STK11 0.841 0.9 0.868 0.846 CCL27 IL10 MMP13 MUC1 NLRP1 STK11 0.877 0.87 0.868 0.873 CCL27 FKBP5 NLRP1 RGS2 SIRT1 TGFB1 0.831 0.912 0.868 0.812 GCKR HFE MMP13 MUC1 SDK1 SLC40A1 0.848 0.898 0.868 0.853 FKBP5 GCKR IL10 NFKB1 SMAD3 STK11 0.839 0.899 0.868 0.841 ABCA1 GH1 HAMP IL10 MUC1 STK11 0.795 0.956 0.868 0.806 CACNA1C FKBP5 GCKR IL10 NFKB1 STK11 0.831 0.914 0.868 0.857 IL10 MMP13 NLRP1 SDK1 SMAD3 STK11 0.892 0.856 0.868 0.864 CRHR1 IL10 MMP13 NFKB1 RGS2 STK11 0.88 0.856 0.868 0.88 ABCA1 FKBP5 IL10 IL1B MUC1 STK11 0.798 0.956 0.868 0.797 HFE IL10 NFKB1 SLC6A3 STK11 VEGFA 0.845 0.899 0.867 0.878 CASP9 IL10 IL18 NFKB1 SIRT1 STK11 0.867 0.871 0.867 0.896 ABCA1 IL10 MUC1 NFKB1 SDK1 STK11 0.83 0.91 0.867 0.861 FKBP5 MMP13 NLRP1 SIRT1 SLC11A2 STK11 0.885 0.857 0.867 0.863 CASP3 FKBP5 GCKR IL10 NFKB1 STK11 0.833 0.913 0.867 0.855 EDAR GCKR IL10 NFKB1 PAX8 STK11 0.833 0.913 0.867 0.823 CASP9 HFE2 IL10 NFKB1 STK11 TGFB1 0.846 0.9 0.867 0.863 CASP9 GCKR IL10 MMP13 NFKB1 STK11 0.899 0.843 0.867 0.856 MMP13 NLRP1 PAX8 RGS2 SLC11A2 STK11 0.908 0.841 0.867 0.866 HAMP IL10 IL1A MUC1 NFKB2 STK11 0.841 0.9 0.867 0.843 IL10 KRT1 MMP13 NLRP1 SMAD3 STK11 0.848 0.9 0.867 0.86 CCL27 FKBP5 IL10 NFKB1 SLC6A3 STK11 0.841 0.9 0.867 0.854 IL10 NFKB2 PAX8 SLC11A2 STK11 VEGFA 0.842 0.902 0.867 0.854 ABCA1 HFE IL6 MMP13 SIRT1 STK11 0.808 0.941 0.867 0.857 IL10 MUC1 NFKB1 SLC6A3 STK11 TGFB1 0.826 0.915 0.867 0.86 HAMP IL10 RGS2 SLC11A2 SLC22A4 STK11 0.804 0.943 0.867 0.851 CASP9 FGFR2 HFE2 IL10 NFKB1 STK11 0.842 0.9 0.867 0.865 CASP3 CASP9 GH1 IL10 NR3C1 STK11 0.813 0.943 0.867 0.809 GH1 HAMP IL10 MUC1 NFKB1 STK11 0.84 0.898 0.867 0.877 CASP9 EPO IL10 NFKB1 SKA2 STK11 0.856 0.886 0.867 0.851 CACNA1C CASP9 HFE2 RGS2 SLC40A1 STK11 0.829 0.914 0.867 0.83 HFE IL10 MMP13 NFKB1 STK11 TGFB1 0.884 0.856 0.867 0.875 CACNA1C IL10 NFKB2 SLC11A2 STK11 VEGFA 0.844 0.902 0.867 0.841 HFE2 IL10 NFKB2 SLC11A2 STK11 VEGFA 0.843 0.9 0.867 0.849 IL10 IL6 NFKB2 SLC11A2 STK11 VEGFA 0.844 0.902 0.867 0.846 CASP9 FKBP5 IL10 MMP13 NLRP1 STK11 0.888 0.856 0.867 0.856 CASP9 IL6 MMP13 NLRP1 SLC11A2 STK11 0.888 0.857 0.867 0.885 CASP3 CASP9 HFE MMP13 SLC40A1 STK11 0.882 0.857 0.867 0.841 GCKR IL10 MMP13 NFKB1 SLC11A2 STK11 0.902 0.843 0.867 0.861 IL10 IL6 MMP13 NLRP1 STK11 TGFB1 0.88 0.871 0.867 0.843 CASP3 HAMP IL10 MUC1 NFKB1 STK11 0.804 0.942 0.867 0.872 CASP9 IL10 NFKB1 SIRT1 SMAD3 STK11 0.857 0.886 0.867 0.865 ABCA1 MMP13 MUC1 NLRP1 SDK1 STK11 0.888 0.855 0.867 0.875 CASP1 IL10 MUC1 NFKB1 SMAD3 STK11 0.805 0.942 0.867 0.835 CASP3 GH1 IL10 MUC1 NFKB1 STK11 0.806 0.942 0.867 0.848 HAMP IL10 NLRP1 PPARG SLC11A2 STK11 0.804 0.943 0.867 0.842 CASP9 HAMP IL10 PAX8 SLC22A4 STK11 0.837 0.9 0.867 0.854 CASP9 GCKR HFE IL6 NFKB1 STK11 0.845 0.898 0.867 0.843 ADAMTS4 CASP3 IL10 MUC1 NFKB1 STK11 0.805 0.942 0.866 0.855 CASP3 IL10 KRT83 MUC1 NFKB1 STK11 0.805 0.942 0.866 0.846 CASP3 IL10 MUC1 NFKB1 NLRP3 STK11 0.805 0.942 0.866 0.855 CASP9 CCL27 EPO RGS2 SLC40A1 STK11 0.815 0.927 0.866 0.86 IL10 IL6 MMP13 NLRP1 SMAD3 STK11 0.85 0.9 0.866 0.863 FKBP5 IL10 MUC1 NFKB2 PAX8 STK11 0.84 0.898 0.866 0.847 CACNA1C CASP9 IL6 MMP13 NLRP1 STK11 0.888 0.857 0.866 0.871 CASP9 FGFR2 HFE IL10 NFKB1 STK11 0.853 0.885 0.866 0.851 CASP9 HFE IL10 NFKB1 PAX8 STK11 0.853 0.885 0.866 0.851 FKBP5 GCKR IL10 NFKB1 SLC11A2 STK11 0.853 0.885 0.866 0.846 ABCA1 IL10 MUC1 NFKB2 RGS2 STK11 0.805 0.942 0.866 0.796 GCKR IL10 MUC1 NFKB1 SLC40A1 STK11 0.804 0.941 0.866 0.84 FGFR2 HFE IL10 NFKB1 SLC6A3 STK11 0.854 0.885 0.866 0.869 FKBP5 GCKR HAMP IL10 NFKB1 STK11 0.827 0.914 0.866 0.844 HAMP IL10 NFKB1 NLRP3 SLC40A1 STK11 0.84 0.9 0.866 0.842 HAMP IL10 NFKB1 SLC11A2 STK11 VEGFA 0.842 0.898 0.866 0.856 CACNA1C IL10 NFKB1 NFKB2 PAX8 STK11 0.83 0.913 0.866 0.846 CD274 GCKR IL10 NFKB1 PAX8 STK11 0.83 0.913 0.866 0.839 CD274 HAMP IL10 NFKB1 PAX8 STK11 0.83 0.913 0.866 0.849 IL10 MMP13 NFKB1 RGS2 STK11 TGFB1 0.906 0.843 0.866 0.887 CRHR1 IL10 IL18 MMP13 NFKB1 SIRT1 0.881 0.857 0.866 0.865 IL6 RGS2 SDK1 SLC40A1 STK11 VEGFA 0.84 0.898 0.866 0.86 CASP9 CCL27 EDAR HAMP IL10 STK11 0.841 0.902 0.866 0.858 MMP13 NLRP1 SDK1 SIRT1 SLC11A2 STK11 0.88 0.855 0.866 0.865 CASP3 IL10 MUC1 NFKB1 SLC11A2 STK11 0.804 0.942 0.866 0.853 CCL27 IL1B MMP13 RGS2 SIRT1 SLC40A1 0.841 0.896 0.866 0.874 CASP9 HFE MMP13 NLRP1 RGS2 STK11 0.887 0.854 0.866 0.872 CD274 CRHR1 IL10 MUC1 NFKB1 STK11 0.804 0.942 0.866 0.869 IL10 MMP13 NLRP1 SDK1 SLC11A2 STK11 0.9 0.843 0.866 0.874 CASP9 MMP13 NFKB2 NLRP1 SLC22A4 STK11 0.889 0.856 0.866 0.862 CACNA1C CASP9 HFE IL10 NFKB1 STK11 0.851 0.886 0.866 0.833 CASP9 HAMP HFE IL10 NFKB1 STK11 0.849 0.886 0.866 0.862 CASP9 HFE IL10 NFKB1 NFKB2 STK11 0.851 0.886 0.866 0.849 FGFR2 IL10 NFKB1 SLC11A2 SLC6A3 STK11 0.837 0.9 0.866 0.844 HAMP IL10 MUC1 NFKB1 RGS2 STK11 0.815 0.927 0.866 0.86 ABCA1 IL10 KRT83 MUC1 NFKB2 STK11 0.803 0.941 0.866 0.812 IL10 IL1B MUC1 NFKB1 SLC6A3 STK11 0.815 0.928 0.866 0.854 FKBP5 IL10 MUC1 NFKB1 SLC40A1 STK11 0.803 0.941 0.866 0.856 CASP9 IL10 NFKB1 NFKB2 SIRT1 STK11 0.852 0.886 0.866 0.862 CCL27 CD274 IL10 NFKB1 SLC6A3 STK11 0.841 0.9 0.866 0.838 HFE IGF1 IL10 NFKB1 SLC6A3 STK11 0.84 0.899 0.866 0.868 CASP1 EPO IL10 NFKB1 NLRP3 STK11 0.816 0.928 0.866 0.813 IL10 NFKB1 RGS2 SDK1 SIRT1 SLC40A1 0.804 0.942 0.866 0.817 CASP9 IL10 NFKB1 NLRP3 STK11 TGFB1 0.854 0.886 0.866 0.849 HFE IL6 MMP13 NFKB1 SLC22A4 STK11 0.858 0.883 0.866 0.878 CCL27 IL1B MMP13 RGS2 SDK1 SLC40A1 0.816 0.927 0.866 0.862 CASP9 CCL27 HAMP IL10 IL6 STK11 0.839 0.902 0.866 0.858 FKBP5 GCKR IL10 NFKB1 PAX8 STK11 0.843 0.899 0.866 0.853 ABCA1 CASP9 EPO RGS2 SLC40A1 STK11 0.829 0.913 0.866 0.839 HAMP HFE IL10 NFKB1 NFKB2 STK11 0.852 0.884 0.866 0.865 CASP9 GCKR MMP13 NFKB1 SLC6A3 STK11 0.85 0.886 0.866 0.839 IL10 MMP13 NFKB1 NLRP1 NLRP3 STK11 0.856 0.885 0.866 0.866 HFE IL10 MMP13 NFKB1 RGS2 STK11 0.892 0.841 0.866 0.883 FGFR2 HAMP HFE IL10 NFKB1 STK11 0.851 0.884 0.865 0.853 ADAMTS4 CASP9 MMP13 NLRP1 RGS2 STK11 0.906 0.84 0.865 0.9 CASP9 FKBP5 MMP13 NLRP1 RGS2 STK11 0.906 0.84 0.865 0.875 CASP9 MMP13 NLRP1 RGS2 SLC11A2 STK11 0.906 0.84 0.865 0.893 IL10 RGS2 SDK1 SLC40A1 SLC6A3 STK11 0.815 0.929 0.865 0.863 HFE IL10 NFKB1 SLC6A3 SMAD3 STK11 0.84 0.899 0.865 0.859 HFE IL10 NFKB1 NR3C1 SIRT1 TGFB1 0.816 0.929 0.865 0.807 ABCA1 GCKR IL10 IL1B MUC1 STK11 0.804 0.941 0.865 0.783 HAMP IL10 NFKB1 NFKB2 SLC6A3 STK11 0.812 0.928 0.865 0.86 ABCA1 IL10 MUC1 NFKB1 PAX8 STK11 0.803 0.941 0.865 0.84 CCL27 IL6 RGS2 SIRT1 SLC40A1 TGFB1 0.806 0.941 0.865 0.879 CASP9 EPO IL10 NFKB1 SIRT1 STK11 0.848 0.886 0.865 0.878 FKBP5 IGF1 IL10 NFKB1 SLC6A3 STK11 0.849 0.885 0.865 0.856 CASP3 HAMP IL10 NFKB1 PAX8 STK11 0.824 0.914 0.865 0.842 IL10 IL18 MUC1 NFKB1 SLC22A4 STK11 0.818 0.927 0.865 0.814 MMP13 NLRP1 NLRP3 RGS2 SDK1 STK11 0.911 0.841 0.865 0.876 CASP1 IL10 IL1B MUC1 NFKB1 STK11 0.816 0.928 0.865 0.847 CASP9 IL10 NFKB1 SIRT1 SLC6A3 STK11 0.849 0.888 0.865 0.874 CASP9 EPO IL10 NFKB1 SLC11A2 STK11 0.83 0.914 0.865 0.851 FKBP5 GCKR IL10 NFKB1 STK11 VEGFA 0.861 0.883 0.865 0.842 CASP9 EPO RGS2 SLC40A1 SMAD3 STK11 0.826 0.912 0.865 0.849 IL1B MMP13 RGS2 SDK1 SLC40A1 VEGFA 0.816 0.927 0.865 0.853 FKBP5 HAMP NLRP1 SIRT1 SLC11A2 STK11 0.849 0.885 0.865 0.828 HAMP IL10 IL1A MUC1 NLRP1 STK11 0.837 0.899 0.865 0.837 FKBP5 IL10 NFKB1 SLC11A2 STK11 VEGFA 0.851 0.884 0.865 0.858 MMP13 NR3C1 RGS2 SLC40A1 STK11 TGFB1 0.865 0.872 0.865 0.858 CCL27 CRHR1 MMP13 NLRP1 SDK1 TGFB1 0.824 0.914 0.865 0.816 IL10 MMP13 MUC1 NLRP1 SDK1 STK11 0.887 0.856 0.865 0.873 ABCA1 CACNA1C IL10 NFKB1 NLRP3 STK11 0.815 0.928 0.865 0.832 ABCA1 GCKR IL10 MUC1 NFKB2 STK11 0.803 0.941 0.865 0.811 IL10 IL18 MUC1 NFKB1 SLC6A3 STK11 0.802 0.941 0.865 0.844 CASP9 CCL27 HAMP IL10 SLC22A4 STK11 0.829 0.915 0.865 0.875 CASP9 MMP13 NLRP1 SLC11A2 STK11 VEGFA 0.851 0.885 0.865 0.867 CD274 IL10 NFKB2 SKA2 SLC11A2 STK11 0.856 0.888 0.865 0.83 CASP1 CRHR1 IL10 MUC1 NFKB1 STK11 0.812 0.928 0.865 0.86 HAMP IL10 MUC1 NFKB2 SLC22A4 STK11 0.81 0.928 0.865 0.834 CCL27 HFE RGS2 SIRT1 SLC40A1 TGFB1 0.813 0.928 0.865 0.839 CCL27 MMP13 RGS2 SLC40A1 SLC6A3 STK11 0.85 0.883 0.865 0.879 CACNA1C HAMP IL10 NLRP1 SLC11A2 STK11 0.812 0.928 0.865 0.851 ABCA1 CASP9 IL10 MUC1 SDK1 STK11 0.811 0.928 0.865 0.82 HAMP IL10 MUC1 NFKB1 STK11 VEGFA 0.812 0.927 0.865 0.868 CRHR1 IL10 MMP13 NFKB1 SIRT1 SLC6A3 0.85 0.886 0.865 0.875 CASP9 IL10 NFKB2 SIRT1 SLC11A2 STK11 0.855 0.889 0.865 0.839 EDAR HFE IL10 MMP13 NFKB1 SIRT1 0.892 0.841 0.865 0.861 FGFR2 FKBP5 HFE IL10 NFKB1 STK11 0.85 0.883 0.865 0.858 GCKR HFE MMP13 SLC11A2 SLC6A3 STK11 0.854 0.886 0.865 0.834 IL10 MUC1 NFKB2 RGS2 STK11 VEGFA 0.814 0.928 0.865 0.823 ADAMTS4 IL10 MUC1 NFKB1 SMAD3 STK11 0.813 0.927 0.865 0.856 EPO HFE2 IL10 NFKB1 SLC11A2 STK11 0.827 0.913 0.865 0.84 CASP9 IL10 MMP13 NLRP1 PAX8 STK11 0.894 0.857 0.865 0.858 CASP9 IL10 NFKB1 NFKB2 NLRP1 STK11 0.824 0.914 0.865 0.869 CASP9 EPO GH1 IL10 NFKB1 STK11 0.826 0.914 0.865 0.853 GCKR IL10 MUC1 NFKB1 SLC6A3 STK11 0.811 0.927 0.865 0.869 CASP1 GCKR IL10 MUC1 NFKB1 STK11 0.813 0.927 0.865 0.849 HAMP HFE IL10 NFKB1 SLC11A2 STK11 0.849 0.886 0.865 0.844 CASP9 EPO IL10 NFKB1 STK11 VEGFA 0.829 0.914 0.865 0.861 ABCA1 CASP9 IL10 NFKB1 SIRT1 STK11 0.849 0.886 0.865 0.861 IL1A MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.795 0.956 0.865 0.755 IL6 MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.795 0.956 0.865 0.764 MUC1 NR3C1 PAX8 SKA2 SLC40A1 STK11 0.795 0.956 0.865 0.755 GCKR IL10 MMP13 NFKB1 NLRP3 STK11 0.911 0.828 0.865 0.858 NR3C1 RGS2 SLC40A1 SMAD3 STK11 TGFB1 0.825 0.913 0.865 0.804 ABCA1 IL10 IL18 MUC1 NFKB2 STK11 0.779 0.972 0.865 0.794 CASP9 MMP13 NLRP1 RGS2 SLC6A3 STK11 0.872 0.869 0.865 0.904 CCL27 KRT1 MMP13 RGS2 SDK1 SLC40A1 0.779 0.985 0.864 0.839 CCL27 IL10 NFKB1 NLRP3 PAX8 STK11 0.863 0.87 0.864 0.847 CASP9 HFE2 MMP13 NLRP1 SLC22A4 STK11 0.904 0.841 0.864 0.876 CASP9 CCL27 RGS2 SLC40A1 STK11 VEGFA 0.802 0.942 0.864 0.85 CASP3 HFE IL10 MUC1 NFKB1 STK11 0.812 0.927 0.864 0.862 GCKR IL10 MUC1 NFKB1 STK11 TGFB1 0.813 0.928 0.864 0.859 IL1B IL6 RGS2 SLC40A1 SLC6A3 STK11 0.867 0.87 0.864 0.879 CACNA1C CASP9 IL10 IL6 NFKB1 STK11 0.824 0.914 0.864 0.861 CASP1 IL10 NFKB1 PPARG STK11 TGFB1 0.835 0.902 0.864 0.828 HAMP IL10 IL6 NFKB1 PAX8 STK11 0.822 0.913 0.864 0.847 CASP9 CD274 IL10 RGS2 SLC40A1 STK11 0.837 0.9 0.864 0.842 IL1B MMP13 RGS2 SIRT1 SLC40A1 SMAD3 0.836 0.896 0.864 0.868 CASP9 CCL27 RGS2 SLC11A2 SLC40A1 STK11 0.802 0.942 0.864 0.851 CCL27 IL10 MUC1 NFKB1 SLC6A3 STK11 0.811 0.927 0.864 0.869 IL10 MUC1 NFKB1 SLC6A3 STK11 VEGFA 0.811 0.927 0.864 0.869 CASP3 CASP9 HFE IL10 NFKB1 STK11 0.861 0.871 0.864 0.851 IL6 RGS2 SIRT1 SLC40A1 STK11 TNF 0.86 0.87 0.864 0.88 IL10 MUC1 NFKB2 SIRT1 SLC11A2 STK11 0.827 0.915 0.864 0.819 ABCA1 IL10 MUC1 NFKB2 NLRP3 STK11 0.779 0.971 0.864 0.819 CASP9 CD274 FKBP5 RGS2 SLC40A1 STK11 0.801 0.943 0.864 0.834 CASP9 GH1 IL10 NFKB1 SKA2 STK11 0.864 0.871 0.864 0.853 HAMP IL10 MMP13 RGS2 SLC40A1 STK11 0.86 0.87 0.864 0.899 IL18 IL6 RGS2 SLC40A1 STK11 TGFB1 0.859 0.871 0.864 0.884 IL6 KRT1 RGS2 SLC40A1 STK11 TGFB1 0.859 0.871 0.864 0.863 IL10 IL6 MMP13 NFKB1 SLC6A3 STK11 0.822 0.913 0.864 0.858 CACNA1C HAMP IL10 STK11 TGFB1 TNF 0.845 0.902 0.864 0.839 IL10 NFKB1 NLRP1 NLRP3 RGS2 STK11 0.827 0.912 0.864 0.864 CCL27 HAMP IL10 MUC1 NLRP1 STK11 0.811 0.927 0.864 0.858 CASP9 CCL27 HFE2 IL10 SLC11A2 STK11 0.818 0.931 0.864 0.809 CASP3 CASP9 CD274 IL10 NR3C1 STK11 0.791 0.957 0.864 0.822 CASP9 CRHR1 EDAR RGS2 SLC40A1 STK11 0.801 0.942 0.864 0.802 CASP9 EPO IGF1 RGS2 SLC40A1 STK11 0.801 0.942 0.864 0.849 CASP1 HAMP HFE IL10 NFKB1 STK11 0.848 0.884 0.864 0.862 IL1B IL6 RGS2 SDK1 SIRT1 SLC40A1 0.813 0.927 0.864 0.847 ABCA1 IL10 IL1B MUC1 SIRT1 STK11 0.793 0.956 0.864 0.789 ABCA1 CCL27 MUC1 NLRP1 SDK1 STK11 0.858 0.883 0.864 0.864 EDAR IL10 MMP13 NLRP1 SMAD3 STK11 0.859 0.886 0.864 0.843 CASP3 CASP9 IL10 NFKB1 STK11 VEGFA 0.822 0.914 0.864 0.851 CCL27 MMP13 NLRP1 SDK1 SIRT1 SMAD3 0.847 0.883 0.864 0.832 CASP1 IL10 MMP13 NFKB1 STK11 TGFB1 0.876 0.857 0.864 0.863 CASP9 IL10 IL6 NFKB1 SIRT1 STK11 0.864 0.871 0.864 0.885 HFE RGS2 SDK1 SKA2 SLC40A1 TNF 0.762 1 0.864 0.774 NFKB2 RGS2 SDK1 SKA2 SLC40A1 TNF 0.762 1 0.864 0.77 CASP9 EDAR MUC1 NLRP1 NR3C1 STK11 0.791 0.957 0.864 0.811 CASP9 MUC1 NLRP1 NR3C1 PPARG STK11 0.791 0.957 0.864 0.787 MMP13 NLRP1 NLRP3 SDK1 SIRT1 TNF 0.828 0.913 0.864 0.855 ABCA1 FKBP5 IL10 MUC1 NFKB1 STK11 0.81 0.926 0.864 0.847 CACNA1C FKBP5 IL10 NFKB1 SLC40A1 STK11 0.822 0.914 0.864 0.849 ABCA1 CD274 IL10 MUC1 NFKB1 STK11 0.811 0.926 0.864 0.84 CASP1 FKBP5 IL10 NFKB1 SLC6A3 STK11 0.822 0.914 0.864 0.863 CASP9 IL10 MUC1 NFKB1 NLRP1 STK11 0.823 0.913 0.864 0.842 CD274 FKBP5 IL10 NFKB1 SLC6A3 STK11 0.822 0.914 0.864 0.863 CD274 IL10 NFKB1 PAX8 SLC6A3 STK11 0.822 0.914 0.864 0.849 CASP9 IL10 IL18 MMP13 NLRP1 STK11 0.875 0.872 0.864 0.86 HFE MMP13 NFKB1 NLRP1 SLC11A2 STK11 0.862 0.869 0.864 0.852 CCL27 GH1 MUC1 NLRP1 SDK1 STK11 0.867 0.869 0.863 0.843 CASP3 CASP9 CCL27 RGS2 SLC40A1 STK11 0.821 0.912 0.863 0.86 ABCA1 HFE2 IL10 MUC1 NFKB2 STK11 0.792 0.956 0.863 0.811 ADAMTS4 CASP9 IL10 NFKB1 STK11 TGFB1 0.862 0.872 0.863 0.853 CASP9 HAMP IL10 MMP13 NFKB1 STK11 0.86 0.871 0.863 0.858 ABCA1 IL10 MUC1 NFKB1 STK11 VEGFA 0.812 0.926 0.863 0.84 IL10 KRT1 MMP13 NFKB1 STK11 TGFB1 0.876 0.857 0.863 0.861 CASP3 CASP9 IL10 NFKB1 SIRT1 STK11 0.859 0.872 0.863 0.888 GCKR HAMP HFE IL10 NFKB1 STK11 0.859 0.87 0.863 0.855 HAMP HFE IL10 NFKB1 RGS2 STK11 0.859 0.87 0.863 0.856 CASP9 HFE KRT1 MMP13 SLC40A1 STK11 0.858 0.872 0.863 0.841 HAMP HFE IL10 NFKB2 SLC11A2 STK11 0.82 0.915 0.863 0.852 HAMP IL10 NFKB1 SLC11A2 STK11 TNF 0.823 0.914 0.863 0.833 IL10 IL18 RGS2 SLC40A1 SLC6A3 STK11 0.821 0.914 0.863 0.842 IL10 IL6 KRT1 NFKB1 SLC11A2 STK11 0.821 0.914 0.863 0.833 ADAMTS4 IL10 MUC1 NFKB1 SLC40A1 STK11 0.79 0.956 0.863 0.838 GH1 IL10 MUC1 NFKB1 SLC40A1 STK11 0.79 0.956 0.863 0.84 HFE IL10 NFKB1 SLC11A2 SLC6A3 STK11 0.849 0.886 0.863 0.849 CASP9 CCL27 HAMP IL10 NFKB1 STK11 0.82 0.914 0.863 0.856 CASP9 CCL27 HAMP IL10 NLRP1 STK11 0.838 0.9 0.863 0.872 CRHR1 IL10 MMP13 NFKB1 SIRT1 STK11 0.864 0.872 0.863 0.895 IL10 MMP13 MUC1 NFKB1 STK11 TGFB1 0.861 0.871 0.863 0.875 CASP9 FKBP5 HFE IL10 NFKB1 STK11 0.86 0.87 0.863 0.862 CASP9 IL10 NFKB1 NLRP3 PAX8 STK11 0.822 0.914 0.863 0.839 FKBP5 HAMP IL10 NFKB1 NLRP3 STK11 0.821 0.913 0.863 0.864 MUC1 NR3C1 PAX8 SLC40A1 STK11 TNF 0.801 0.942 0.863 0.77 CASP9 IL10 NFKB1 NLRP1 NR3C1 STK11 0.8 0.942 0.863 0.843 CCL27 IL10 IL1A NLRP1 SLC11A2 STK11 0.867 0.871 0.863 0.829 ABCA1 CASP9 HAMP IL10 STK11 TGFB1 0.823 0.914 0.863 0.856 GCKR IL10 MUC1 NFKB1 SIRT1 STK11 0.822 0.914 0.863 0.871 CD274 IL10 IL18 MMP13 NFKB1 STK11 0.878 0.857 0.863 0.848 CACNA1C FKBP5 IL10 MUC1 NFKB2 STK11 0.809 0.926 0.863 0.824 CASP9 HAMP MUC1 NLRP1 NR3C1 STK11 0.803 0.943 0.863 0.807 ABCA1 GCKR IL10 MUC1 NFKB1 STK11 0.81 0.926 0.863 0.854 HAMP IL10 NFKB1 NLRP3 SLC6A3 STK11 0.822 0.914 0.863 0.84 IL10 MMP13 NFKB1 NFKB2 RGS2 STK11 0.873 0.856 0.863 0.875 CASP9 FKBP5 MMP13 NLRP1 SLC22A4 STK11 0.86 0.871 0.863 0.864 ADAMTS4 HAMP IL10 MUC1 NFKB1 STK11 0.821 0.912 0.863 0.873 FGFR2 HAMP IL10 MUC1 NFKB1 STK11 0.821 0.912 0.863 0.871 HAMP IL10 KRT1 MUC1 NFKB1 STK11 0.821 0.912 0.863 0.855 HAMP IL10 KRT83 MUC1 NFKB1 STK11 0.821 0.912 0.863 0.857 HAMP IL10 MUC1 NFKB1 NFKB2 STK11 0.821 0.912 0.863 0.868 CCL27 MMP13 MUC1 RGS2 SDK1 SLC40A1 0.794 0.956 0.863 0.824 MUC1 NLRP1 NR3C1 SLC40A1 STK11 TNF 0.801 0.942 0.863 0.777 ABCA1 IL1B IL6 RGS2 SLC40A1 STK11 0.866 0.869 0.863 0.884 CD274 HFE IL10 MMP13 NFKB1 STK11 0.859 0.869 0.863 0.875 CASP9 HFE IL18 MMP13 SLC6A3 STK11 0.847 0.886 0.863 0.829 CASP9 MMP13 RGS2 SDK1 SLC40A1 STK11 0.821 0.913 0.863 0.852 EPO IL10 NFKB2 SLC11A2 STK11 VEGFA 0.825 0.915 0.863 0.851 IL10 MUC1 NFKB1 NLRP3 SLC40A1 STK11 0.788 0.956 0.863 0.842 FKBP5 MMP13 NLRP1 SDK1 SLC11A2 STK11 0.908 0.827 0.863 0.862 FKBP5 IL10 MUC1 NFKB1 STK11 VEGFA 0.823 0.913 0.863 0.865 IL10 MUC1 NFKB1 PAX8 STK11 VEGFA 0.823 0.913 0.863 0.86 MMP13 RGS2 SLC40A1 SLC6A3 STK11 TGFB1 0.858 0.871 0.863 0.89 CCL27 IL6 RGS2 SDK1 SLC40A1 STK11 0.823 0.913 0.863 0.872 IL10 MMP13 NFKB1 NFKB2 STK11 TGFB1 0.871 0.857 0.863 0.868 IL10 MMP13 NFKB1 STK11 TGFB1 VEGFA 0.871 0.857 0.863 0.865 ABCA1 CCL27 MMP13 RGS2 SIRT1 SLC40A1 0.854 0.881 0.863 0.862 FKBP5 HFE NLRP1 SIRT1 SLC11A2 STK11 0.86 0.871 0.863 0.845 CASP9 GH1 RGS2 SLC22A4 SLC40A1 STK11 0.81 0.928 0.863 0.827 IL10 KRT1 NFKB1 NLRP3 SLC11A2 STK11 0.82 0.914 0.863 0.817 CASP1 HFE IL10 IL6 NFKB1 STK11 0.858 0.87 0.863 0.855 EPO GCKR IL10 MMP13 NFKB1 STK11 0.874 0.857 0.863 0.851 CASP3 IL10 NFKB1 NLRP3 SLC11A2 STK11 0.822 0.914 0.863 0.812 FKBP5 IL10 NFKB1 SKA2 SLC6A3 STK11 0.821 0.914 0.863 0.851 CACNA1C GCKR HFE IL10 NFKB1 STK11 0.859 0.87 0.863 0.838 CASP9 IL10 NFKB1 SLC11A2 STK11 TGFB1 0.834 0.9 0.863 0.865 CRHR1 IL10 MMP13 NFKB1 SDK1 STK11 0.875 0.857 0.863 0.88 CCL27 GH1 MMP13 RGS2 SDK1 SLC40A1 0.785 0.971 0.863 0.824 CD274 IL10 NFKB1 NLRP3 SLC11A2 STK11 0.822 0.914 0.863 0.816 IL10 MUC1 NFKB2 NLRP1 SKA2 STK11 0.821 0.913 0.863 0.838 HFE2 IL10 NFKB1 SLC11A2 STK11 VEGFA 0.822 0.912 0.863 0.848 CASP3 CASP9 IL10 MMP13 NLRP1 STK11 0.907 0.842 0.863 0.874 IL10 KRT1 NFKB1 SLC11A2 STK11 TGFB1 0.841 0.902 0.863 0.854 CASP3 HFE IL10 NFKB1 SLC6A3 STK11 0.823 0.914 0.863 0.874 CASP1 HAMP IL10 NFKB1 SLC6A3 STK11 0.821 0.914 0.863 0.856 CCL27 IL10 IL1A NFKB1 SLC6A3 STK11 0.822 0.914 0.863 0.84 GCKR IL10 MUC1 NFKB1 PAX8 STK11 0.822 0.913 0.863 0.858 CASP9 CCL27 NFKB1 RGS2 SLC40A1 STK11 0.81 0.928 0.863 0.843 CASP9 HFE2 RGS2 SLC40A1 STK11 VEGFA 0.813 0.927 0.863 0.847 CASP9 CCL27 GCKR HAMP IL10 STK11 0.822 0.915 0.863 0.859 IL10 IL18 NFKB2 SIRT1 SLC11A2 STK11 0.833 0.902 0.863 0.821 CASP9 FGFR2 HFE MMP13 SLC40A1 STK11 0.86 0.872 0.863 0.839 CASP9 HFE MMP13 SLC22A4 SLC40A1 STK11 0.857 0.871 0.863 0.853 CASP9 HFE MMP13 SLC40A1 STK11 VEGFA 0.857 0.871 0.863 0.845 CRHR1 MMP13 NLRP1 SIRT1 SLC11A2 STK11 0.862 0.872 0.863 0.86 ABCA1 CCL27 MUC1 SDK1 STK11 TGFB1 0.818 0.913 0.862 0.835 ABCA1 HFE IL10 MMP13 NFKB1 SIRT1 0.837 0.899 0.862 0.869 HFE IL10 IL18 NFKB1 SLC6A3 STK11 0.849 0.886 0.862 0.867 CASP1 IL10 MUC1 NFKB1 SLC40A1 STK11 0.82 0.912 0.862 0.851 EPO IL10 MUC1 NFKB1 SKA2 STK11 0.82 0.912 0.862 0.86 IL10 MUC1 NFKB1 PAX8 SKA2 STK11 0.82 0.912 0.862 0.867 IL1B IL6 NFKB1 RGS2 SLC40A1 STK11 0.877 0.855 0.862 0.881 HAMP IL10 MMP13 NFKB1 STK11 TNF 0.844 0.885 0.862 0.854 ADAMTS4 CASP1 IL10 NFKB1 PAX8 STK11 0.833 0.899 0.862 0.818 HAMP IL10 MUC1 NFKB1 SLC22A4 STK11 0.82 0.913 0.862 0.858 IL10 IL18 NFKB2 SLC11A2 STK11 VEGFA 0.823 0.915 0.862 0.832 CD274 CRHR1 IL1B IL6 RGS2 SLC40A1 0.797 0.942 0.862 0.793 CRHR1 IL1B MMP13 RGS2 SDK1 SLC40A1 0.8 0.942 0.862 0.858 IL10 MMP13 NFKB1 NLRP1 RGS2 STK11 0.897 0.841 0.862 0.889 HAMP IL10 IL1A MUC1 NFKB1 STK11 0.818 0.913 0.862 0.876 CRHR1 FKBP5 HAMP IL10 NFKB1 STK11 0.829 0.899 0.862 0.853 CRHR1 FKBP5 IL10 NFKB1 SMAD3 STK11 0.829 0.899 0.862 0.85 CRHR1 GCKR IL10 NFKB1 PAX8 STK11 0.829 0.899 0.862 0.851 IL10 NFKB1 PAX8 RGS2 STK11 TGFB1 0.831 0.9 0.862 0.856 IL10 MMP13 NFKB1 NLRP3 SIRT1 STK11 0.872 0.856 0.862 0.89 ABCA1 IL10 MUC1 NFKB1 SKA2 STK11 0.819 0.912 0.862 0.858 ADAMTS4 IL10 MUC1 NFKB1 SKA2 STK11 0.819 0.912 0.862 0.862 CASP1 HAMP IL10 IL1A NFKB1 STK11 0.819 0.914 0.862 0.823 CASP9 CCL27 FGFR2 HAMP IL10 STK11 0.82 0.915 0.862 0.862 CASP9 CCL27 HAMP IL10 PAX8 STK11 0.82 0.915 0.862 0.837 FKBP5 IL10 MUC1 NFKB1 SKA2 STK11 0.819 0.912 0.862 0.862 GCKR IL10 MUC1 NFKB1 SKA2 STK11 0.819 0.912 0.862 0.872 HFE2 IL10 MUC1 NFKB1 SKA2 STK11 0.819 0.912 0.862 0.863 IL10 MUC1 NFKB1 SKA2 SLC11A2 STK11 0.819 0.912 0.862 0.864 CASP3 IL6 RGS2 SLC40A1 STK11 TGFB1 0.872 0.857 0.862 0.872 IL10 MMP13 NLRP1 SLC11A2 STK11 VEGFA 0.858 0.871 0.862 0.865 IL6 RGS2 SKA2 SLC40A1 STK11 TGFB1 0.872 0.857 0.862 0.886 NLRP1 SDK1 SIRT1 SLC11A2 STK11 VEGFA 0.857 0.87 0.862 0.861 ADAMTS4 CRHR1 IL10 NFKB1 SLC11A2 STK11 0.831 0.9 0.862 0.839 GCKR HFE2 IL10 NFKB1 SLC11A2 STK11 0.835 0.9 0.862 0.847 CASP9 IL10 MMP13 NLRP1 SLC40A1 STK11 0.869 0.872 0.862 0.852 CASP9 MMP13 MUC1 NLRP1 PAX8 STK11 0.83 0.9 0.862 0.859 CASP9 NLRP1 RGS2 SLC40A1 STK11 TGFB1 0.812 0.927 0.862 0.854 IL10 KRT1 MMP13 NFKB1 SKA2 STK11 0.873 0.856 0.862 0.847 CRHR1 GCKR IL10 MMP13 NFKB1 SIRT1 0.859 0.872 0.862 0.858 CRHR1 HFE IL10 MMP13 NFKB1 STK11 0.858 0.87 0.862 0.879 CASP9 HFE IL10 NFKB1 NLRP1 STK11 0.83 0.899 0.862 0.863 IL10 MUC1 NFKB2 PAX8 SIRT1 STK11 0.8 0.943 0.862 0.833 CASP9 CRHR1 IL10 MUC1 NFKB1 STK11 0.819 0.914 0.862 0.851 GCKR IL10 NFKB1 PAX8 SMAD3 STK11 0.832 0.898 0.862 0.848 CASP9 CCL27 FGFR2 RGS2 SLC40A1 STK11 0.808 0.928 0.862 0.848 CASP9 CCL27 IGF1 RGS2 SLC40A1 STK11 0.808 0.928 0.862 0.833 CASP9 CCL27 IL18 RGS2 SLC40A1 STK11 0.808 0.928 0.862 0.844 CASP9 KRT83 RGS2 SLC11A2 SLC40A1 STK11 0.808 0.928 0.862 0.842 CASP9 RGS2 SLC22A4 SLC40A1 STK11 VEGFA 0.808 0.928 0.862 0.837 CACNA1C CCL27 RGS2 SIRT1 SLC40A1 TGFB1 0.799 0.941 0.862 0.844 ABCA1 CRHR1 IL1B IL6 RGS2 SLC40A1 0.796 0.942 0.862 0.814 ABCA1 CASP1 CCL27 SIRT1 SLC11A2 SLC40A1 0.832 0.899 0.862 0.838 CCL27 NLRP1 RGS2 SIRT1 TGFB1 TNF 0.821 0.912 0.862 0.82 IL6 MMP13 NLRP1 RGS2 SDK1 STK11 0.919 0.826 0.862 0.884 CASP9 HAMP IL10 MMP13 NLRP1 STK11 0.874 0.857 0.862 0.869 CD274 CRHR1 IL10 MMP13 NFKB1 SIRT1 0.861 0.872 0.862 0.858 FKBP5 HFE IL6 NFKB1 STK11 VEGFA 0.819 0.912 0.862 0.859 CASP9 CCL27 FGFR2 IL10 IL6 STK11 0.824 0.915 0.862 0.796 HAMP IL10 MUC1 NFKB1 NR3C1 STK11 0.819 0.912 0.862 0.859 CASP1 IL10 IL6 MMP13 NFKB1 STK11 0.876 0.856 0.862 0.851 HFE2 IL10 NFKB1 NLRP3 PAX8 STK11 0.813 0.927 0.862 0.853 CASP3 CASP9 IL10 NFKB1 NLRP1 STK11 0.808 0.928 0.862 0.858 IL10 NFKB2 RGS2 SIRT1 SLC11A2 STK11 0.835 0.902 0.862 0.822 CRHR1 FKBP5 HFE2 IL10 NFKB1 STK11 0.829 0.899 0.862 0.842 HFE IL1B IL6 RGS2 SDK1 SLC40A1 0.766 0.986 0.862 0.836 IL1A MUC1 NLRP1 NR3C1 STK11 TNF 0.801 0.941 0.862 0.808 FKBP5 GCKR IL10 NFKB1 NR3C1 STK11 0.811 0.928 0.862 0.819 ADAMTS4 GCKR IL10 NFKB1 SLC11A2 STK11 0.831 0.9 0.862 0.831 ADAMTS4 IL10 NFKB1 NLRP3 SLC11A2 STK11 0.831 0.9 0.862 0.816 CD274 HAMP IL10 IL1A NFKB1 STK11 0.829 0.899 0.862 0.835 EPO GCKR IL10 NFKB1 SLC11A2 STK11 0.831 0.9 0.862 0.829 EPO GH1 IL10 NFKB1 SLC11A2 STK11 0.831 0.9 0.862 0.828 HAMP IL10 NFKB1 PAX8 SLC11A2 STK11 0.831 0.9 0.862 0.839 IL10 IL6 NFKB1 NLRP1 STK11 TGFB1 0.83 0.9 0.862 0.841 ADAMTS4 HFE NLRP1 SIRT1 SLC11A2 STK11 0.832 0.899 0.862 0.831 CASP9 CD274 HAMP IL10 NFKB1 STK11 0.83 0.9 0.862 0.86 CASP9 HAMP HFE2 IL10 NFKB1 STK11 0.83 0.9 0.862 0.851 ABCA1 IL10 MUC1 NFKB1 NFKB2 STK11 0.818 0.912 0.862 0.839 HAMP IGF1 IL10 MUC1 NLRP1 STK11 0.818 0.913 0.862 0.838 CASP9 EDAR FKBP5 RGS2 SLC40A1 STK11 0.807 0.928 0.862 0.839 CASP9 FKBP5 GH1 RGS2 SLC40A1 STK11 0.807 0.928 0.862 0.825 CASP9 FKBP5 HAMP RGS2 SLC40A1 STK11 0.807 0.928 0.862 0.83 GCKR HFE IL10 NFKB1 SLC6A3 STK11 0.833 0.9 0.862 0.872 CACNA1C HAMP IL10 NFKB1 NLRP3 STK11 0.829 0.9 0.862 0.844 CACNA1C IL10 IL6 NFKB2 SLC11A2 STK11 0.834 0.9 0.862 0.83 CASP3 HAMP IL10 NFKB1 NLRP3 STK11 0.829 0.9 0.862 0.849 CASP9 CRHR1 HFE IL10 NFKB1 STK11 0.83 0.9 0.862 0.869 GH1 HAMP IL10 NFKB1 NLRP3 STK11 0.829 0.9 0.862 0.844 CASP3 CCL27 NLRP1 RGS2 SIRT1 TNF 0.821 0.912 0.861 0.827 CASP9 KRT83 MMP13 NLRP1 STK11 TGFB1 0.864 0.871 0.861 0.835 CASP9 IL1A MUC1 NLRP1 RGS2 STK11 0.836 0.898 0.861 0.82 CASP9 HAMP IL10 IL6 NFKB1 STK11 0.83 0.9 0.861 0.871 CASP9 HAMP IL10 NFKB1 RGS2 STK11 0.83 0.9 0.861 0.876 CASP9 HAMP IL10 NFKB1 SLC11A2 STK11 0.83 0.9 0.861 0.865 HAMP IL10 MUC1 NFKB1 NLRP1 STK11 0.821 0.912 0.861 0.847 IL18 MMP13 NLRP1 SIRT1 SLC11A2 STK11 0.87 0.856 0.861 0.876 CRHR1 HAMP HFE IL10 NFKB1 STK11 0.831 0.899 0.861 0.869 EDAR FKBP5 GCKR IL10 NFKB1 STK11 0.843 0.884 0.861 0.828 FKBP5 IL10 NFKB1 RGS2 STK11 TGFB1 0.845 0.885 0.861 0.856 CCL27 HAMP IL10 NLRP1 SLC11A2 STK11 0.818 0.913 0.861 0.86 IL10 MUC1 NFKB1 NLRP3 STK11 TGFB1 0.819 0.913 0.861 0.856 HFE IL10 IL1B MUC1 NFKB1 STK11 0.832 0.899 0.861 0.861 CACNA1C IL10 MMP13 NFKB1 STK11 TGFB1 0.87 0.857 0.861 0.856 CACNA1C CASP9 HFE MMP13 SLC22A4 STK11 0.855 0.871 0.861 0.846 HFE2 IL10 KRT1 NFKB1 PAX8 STK11 0.808 0.927 0.861 0.844 HFE IL10 MMP13 MUC1 NFKB2 STK11 0.859 0.87 0.861 0.877 CASP9 MMP13 NLRP1 STK11 TGFB1 VEGFA 0.872 0.857 0.861 0.85 GH1 RGS2 SLC40A1 SMAD3 STK11 TNF 0.795 0.941 0.861 0.812 CRHR1 IL10 MUC1 NFKB1 SLC22A4 STK11 0.818 0.912 0.861 0.844 CASP9 CCL27 IL10 MMP13 NLRP1 STK11 0.878 0.857 0.861 0.854 IL10 KRT83 MUC1 NFKB2 SIRT1 STK11 0.801 0.942 0.861 0.796 GCKR IL10 MUC1 NFKB2 SIRT1 STK11 0.797 0.943 0.861 0.804 HAMP IL10 NFKB1 PAX8 RGS2 STK11 0.845 0.885 0.861 0.846 CCL27 HFE RGS2 SLC6A3 STK11 TGFB1 0.835 0.899 0.861 0.797 IL10 NFKB1 PAX8 SDK1 STK11 TGFB1 0.876 0.857 0.861 0.845 CASP9 EDAR MMP13 NLRP1 SLC22A4 STK11 0.876 0.856 0.861 0.854 CASP9 HFE MMP13 RGS2 SLC22A4 STK11 0.865 0.869 0.861 0.86 CRHR1 IL10 MMP13 NLRP1 SDK1 TNF 0.849 0.884 0.861 0.826 IGF1 IL10 MUC1 NFKB2 PAX8 STK11 0.797 0.941 0.861 0.833 FKBP5 HAMP IL10 NFKB1 SLC11A2 STK11 0.848 0.884 0.861 0.846 IL10 NFKB1 PAX8 SLC11A2 SMAD3 STK11 0.829 0.899 0.861 0.834 IL18 NLRP1 SIRT1 SLC11A2 STK11 VEGFA 0.857 0.869 0.861 0.843 HFE2 IL10 MMP13 NLRP1 SMAD3 STK11 0.87 0.872 0.861 0.867 ADAMTS4 CASP9 MMP13 NLRP1 SLC22A4 STK11 0.871 0.856 0.861 0.876 CASP9 IL10 IL1B RGS2 SLC40A1 STK11 0.845 0.886 0.861 0.867 IL10 MMP13 NLRP1 PPARG SMAD3 STK11 0.846 0.886 0.861 0.846 CASP1 IL10 NFKB1 PAX8 STK11 VEGFA 0.847 0.884 0.861 0.835 ABCA1 CCL27 RGS2 SIRT1 SLC40A1 TGFB1 0.797 0.941 0.861 0.844 CASP1 IL10 MMP13 NFKB1 SLC40A1 STK11 0.868 0.859 0.861 0.879 CACNA1C CASP9 CD274 MMP13 STK11 VEGFA 0.865 0.872 0.861 0.839 CASP3 HAMP IL10 NFKB1 SLC11A2 STK11 0.83 0.9 0.861 0.844 CASP9 CCL27 FKBP5 IL6 PAX8 STK11 0.864 0.874 0.861 0.814 ADAMTS4 CASP9 CCL27 HAMP IL10 STK11 0.828 0.902 0.861 0.839 CACNA1C FKBP5 IL10 NFKB1 SLC6A3 STK11 0.829 0.9 0.861 0.856 CASP9 HAMP IGF1 IL10 NFKB1 STK11 0.829 0.9 0.861 0.863 CCL27 IL10 NFKB1 PAX8 SLC6A3 STK11 0.829 0.9 0.861 0.863 FKBP5 HFE IL10 MUC1 NFKB1 STK11 0.828 0.898 0.861 0.876 FKBP5 IL10 NFKB2 RGS2 SLC11A2 STK11 0.832 0.902 0.861 0.843 HAMP IL10 SLC11A2 SLC40A1 SMAD3 STK11 0.831 0.899 0.861 0.843 FKBP5 HAMP IL10 MUC1 NFKB1 STK11 0.829 0.898 0.861 0.868 CASP9 HFE2 RGS2 SLC22A4 SLC40A1 STK11 0.822 0.913 0.861 0.832 CASP1 CRHR1 MMP13 RGS2 SDK1 SLC40A1 0.777 0.972 0.861 0.834 CCL27 EPO RGS2 SIRT1 SLC40A1 TGFB1 0.797 0.941 0.861 0.857 ABCA1 CRHR1 IL10 IL1B MUC1 STK11 0.8 0.942 0.861 0.781 CASP9 PAX8 RGS2 SLC22A4 SLC40A1 STK11 0.818 0.914 0.861 0.816 CACNA1C CCL27 MUC1 NLRP1 SDK1 STK11 0.845 0.884 0.861 0.857 CASP9 EPO HFE IL10 NFKB1 STK11 0.842 0.886 0.861 0.86 EPO HFE IL6 MMP13 NFKB1 STK11 0.887 0.84 0.861 0.859 GH1 IL10 MMP13 NFKB1 NFKB2 STK11 0.884 0.842 0.861 0.851 CASP9 HAMP HFE IL10 NFKB2 STK11 0.827 0.9 0.861 0.843 HFE IL10 MUC1 NFKB1 SIRT1 STK11 0.87 0.856 0.861 0.889 IL6 RGS2 SIRT1 SLC40A1 STK11 TGFB1 0.889 0.842 0.861 0.871 CASP1 HFE IL10 NFKB1 SLC40A1 STK11 0.828 0.9 0.861 0.867 CASP9 EDAR FGFR2 RGS2 SLC40A1 STK11 0.817 0.914 0.861 0.821 HFE IL10 NFKB1 SLC11A2 STK11 VEGFA 0.842 0.885 0.861 0.847 CASP9 IL10 IL6 NFKB1 RGS2 STK11 0.831 0.899 0.861 0.855 ABCA1 FKBP5 IL10 MUC1 NFKB2 STK11 0.796 0.942 0.861 0.812 ABCA1 HFE MUC1 SLC40A1 SLC6A3 STK11 0.796 0.942 0.861 0.823 CASP9 IL10 NFKB1 SIRT1 SKA2 STK11 0.873 0.859 0.861 0.869 ADAMTS4 CASP9 EPO RGS2 SLC40A1 STK11 0.817 0.914 0.861 0.834 CASP9 EPO FGFR2 RGS2 SLC40A1 STK11 0.817 0.914 0.861 0.834 CD274 IL10 NFKB2 SIRT1 SLC11A2 STK11 0.826 0.917 0.861 0.833 CASP9 CCL27 HFE NLRP1 SLC11A2 STK11 0.827 0.899 0.861 0.858 CASP9 MUC1 NLRP1 NR3C1 SLC6A3 STK11 0.807 0.928 0.861 0.806 CASP9 FKBP5 IL10 NFKB1 NLRP1 STK11 0.805 0.928 0.861 0.865 HFE IL10 NFKB1 SLC6A3 STK11 TGFB1 0.843 0.886 0.861 0.861 CASP9 MMP13 NLRP1 SDK1 SLC6A3 STK11 0.885 0.842 0.861 0.848 FKBP5 MMP13 MUC1 NLRP1 SLC22A4 STK11 0.829 0.899 0.861 0.861 ADAMTS4 IL10 NFKB2 SIRT1 SLC11A2 STK11 0.844 0.886 0.861 0.837 IL10 KRT83 NFKB1 SLC11A2 STK11 TGFB1 0.849 0.886 0.861 0.86 IL10 NFKB1 PAX8 SLC11A2 STK11 TGFB1 0.849 0.886 0.861 0.86 IL10 MMP13 NLRP1 RGS2 SLC11A2 STK11 0.911 0.827 0.861 0.88 CASP9 IL10 NFKB1 NR3C1 STK11 VEGFA 0.808 0.928 0.861 0.835 HFE IL10 KRT83 NFKB1 SLC6A3 STK11 0.859 0.87 0.861 0.862 CACNA1C IL10 MMP13 NLRP1 SMAD3 STK11 0.834 0.9 0.861 0.856 HFE IL10 NFKB1 SLC6A3 STK11 TNF 0.832 0.899 0.861 0.846 FGFR2 IL10 SLC11A2 SLC40A1 STK11 TNF 0.809 0.928 0.861 0.855 CASP9 IL10 NLRP1 NR3C1 PAX8 STK11 0.807 0.928 0.861 0.821 CASP9 IL10 NFKB1 SLC22A4 STK11 TGFB1 0.862 0.871 0.861 0.862 FKBP5 GCKR NLRP1 SIRT1 SLC11A2 STK11 0.845 0.886 0.861 0.839 CASP1 GCKR IL10 NFKB1 PAX8 STK11 0.836 0.899 0.861 0.836 FKBP5 GCKR IL10 NFKB1 NFKB2 STK11 0.836 0.899 0.861 0.853 ABCA1 CASP9 HFE IL10 MMP13 STK11 0.826 0.9 0.86 0.843 CCL27 MMP13 NLRP1 RGS2 SMAD3 STK11 0.918 0.823 0.86 0.855 IL10 MUC1 NFKB2 NLRP1 SIRT1 STK11 0.818 0.912 0.86 0.827 CASP1 IL10 NFKB1 SDK1 SLC40A1 STK11 0.828 0.9 0.86 0.869 CASP1 CASP3 IL10 MUC1 NFKB1 STK11 0.796 0.942 0.86 0.851 CASP3 IL10 MUC1 NFKB1 STK11 TNF 0.796 0.942 0.86 0.84 IL10 MMP13 NFKB1 SIRT1 SLC11A2 STK11 0.892 0.842 0.86 0.888 CASP9 FGFR2 IL10 MUC1 NFKB1 STK11 0.827 0.898 0.86 0.847 CASP9 FKBP5 NLRP1 RGS2 SLC40A1 STK11 0.825 0.912 0.86 0.876 IL10 NFKB1 NFKB2 RGS2 SLC11A2 STK11 0.842 0.886 0.86 0.818 CASP9 CCL27 PAX8 SIRT1 SLC11A2 STK11 0.824 0.915 0.86 0.792 CASP3 EPO IL10 MUC1 NFKB1 STK11 0.795 0.942 0.86 0.855 CASP3 IL10 MUC1 NFKB2 NLRP1 STK11 0.794 0.943 0.86 0.839 CCL27 HAMP IL10 NFKB1 NLRP3 STK11 0.827 0.899 0.86 0.853 CD274 IL10 NFKB1 SDK1 SLC6A3 STK11 0.829 0.899 0.86 0.852 ABCA1 HAMP HFE IL10 NFKB1 STK11 0.809 0.928 0.86 0.843 CCL27 HFE RGS2 SDK1 SLC40A1 TNF 0.759 1 0.86 0.797 HAMP IL10 IL18 NFKB2 SLC11A2 STK11 0.835 0.903 0.86 0.818 CASP3 FGFR2 IL10 NFKB1 SLC11A2 STK11 0.842 0.885 0.86 0.847 CASP9 HFE IL10 NFKB1 SLC22A4 STK11 0.84 0.885 0.86 0.854 CASP9 IL6 MMP13 NLRP1 NLRP3 STK11 0.878 0.859 0.86 0.852 EPO HAMP IL10 MMP13 NFKB1 STK11 0.84 0.885 0.86 0.863 CASP3 IL10 MUC1 NFKB1 NR3C1 STK11 0.794 0.942 0.86 0.818 CASP3 IL10 MUC1 NFKB1 RGS2 STK11 0.794 0.942 0.86 0.844 CASP3 IL10 MUC1 NFKB1 STK11 VEGFA 0.794 0.942 0.86 0.862 CD274 IL10 MMP13 NLRP1 SMAD3 STK11 0.835 0.9 0.86 0.873 FGFR2 IL10 MUC1 NFKB1 PAX8 STK11 0.829 0.898 0.86 0.851 ABCA1 IL10 MMP13 MUC1 NFKB1 STK11 0.826 0.898 0.86 0.862 FGFR2 IL10 NFKB1 NLRP1 SLC11A2 STK11 0.829 0.898 0.86 0.85 CASP3 HAMP HFE IL10 NFKB1 STK11 0.843 0.884 0.86 0.858 GH1 HAMP HFE IL10 NFKB1 STK11 0.843 0.884 0.86 0.865 HFE IL10 NFKB1 STK11 TNF VEGFA 0.843 0.884 0.86 0.851 CASP9 IL10 MUC1 NFKB1 SLC40A1 STK11 0.804 0.928 0.86 0.855 ABCA1 IGF1 IL10 MUC1 NFKB2 STK11 0.794 0.941 0.86 0.788 CASP9 HFE MMP13 PAX8 SLC40A1 STK11 0.856 0.872 0.86 0.834 CASP9 CRHR1 IL10 KRT1 NFKB1 STK11 0.83 0.9 0.86 0.861 EPO IL10 MUC1 NFKB2 NR3C1 STK11 0.798 0.941 0.86 0.826 CASP3 IL10 NFKB1 NLRP3 PAX8 STK11 0.819 0.913 0.86 0.844 MMP13 NLRP1 SDK1 SLC11A2 SLC6A3 STK11 0.87 0.856 0.86 0.864 KRT1 MUC1 NR3C1 SLC40A1 STK11 TNF 0.805 0.927 0.86 0.767 MUC1 NFKB1 NR3C1 SLC40A1 STK11 TNF 0.805 0.927 0.86 0.765 MUC1 NR3C1 SLC40A1 SMAD3 STK11 TNF 0.805 0.927 0.86 0.753 EPO GCKR IL10 NFKB1 PAX8 STK11 0.818 0.914 0.86 0.846 CRHR1 FKBP5 HAMP IL10 STK11 TGFB1 0.811 0.929 0.86 0.808 EPO HAMP IL10 NFKB1 PAX8 STK11 0.816 0.914 0.86 0.844 FKBP5 HAMP IL10 NFKB1 NFKB2 STK11 0.816 0.914 0.86 0.853 GCKR HAMP IL10 NFKB1 PAX8 STK11 0.816 0.914 0.86 0.837 IL10 MMP13 NFKB1 NLRP3 STK11 VEGFA 0.884 0.842 0.86 0.851 HFE IL1B MMP13 RGS2 SDK1 SLC40A1 0.794 0.942 0.86 0.85 CASP9 IL10 IL1B NFKB1 SIRT1 STK11 0.839 0.886 0.86 0.857 CRHR1 FKBP5 HFE IL10 NFKB1 STK11 0.841 0.884 0.86 0.872 CACNA1C IL10 KRT1 NFKB1 PAX8 STK11 0.818 0.913 0.86 0.837 CACNA1C IL10 NFKB1 PAX8 STK11 VEGFA 0.818 0.913 0.86 0.848 CASP3 FKBP5 IL10 KRT1 NFKB1 STK11 0.818 0.913 0.86 0.834 CASP3 GCKR IL10 NFKB1 PAX8 STK11 0.818 0.913 0.86 0.834 CD274 IL10 KRT1 NFKB1 PAX8 STK11 0.818 0.913 0.86 0.832 CD274 IL10 NFKB1 PAX8 STK11 VEGFA 0.818 0.913 0.86 0.844 EDAR IL10 NFKB1 NFKB2 PAX8 STK11 0.818 0.913 0.86 0.823 EDAR IL10 NFKB1 PAX8 STK11 VEGFA 0.818 0.913 0.86 0.826 EPO IL10 KRT1 NFKB1 PAX8 STK11 0.818 0.913 0.86 0.828 GCKR GH1 IL10 NFKB1 PAX8 STK11 0.818 0.913 0.86 0.839 IL10 KRT1 NFKB1 NFKB2 PAX8 STK11 0.818 0.913 0.86 0.825 IL10 NFKB1 NFKB2 PAX8 STK11 VEGFA 0.818 0.913 0.86 0.844 FKBP5 IL10 MUC1 NFKB2 SIRT1 STK11 0.806 0.929 0.86 0.815 CASP1 HAMP IL10 SLC11A2 SLC22A4 STK11 0.809 0.929 0.86 0.846 CASP9 GH1 IL10 NFKB1 STK11 TGFB1 0.845 0.886 0.86 0.858 ADAMTS4 CASP1 IL10 MUC1 NFKB1 STK11 0.795 0.941 0.86 0.841 CASP1 GH1 IL10 MUC1 NFKB1 STK11 0.795 0.941 0.86 0.832 CASP1 IL10 KRT83 MUC1 NFKB1 STK11 0.795 0.941 0.86 0.835 CASP9 HFE MMP13 NLRP1 SLC6A3 STK11 0.867 0.857 0.86 0.883 CRHR1 IL10 KRT1 MMP13 NFKB1 SIRT1 0.869 0.857 0.86 0.881 CRHR1 IL10 MMP13 NFKB1 SIRT1 SKA2 0.872 0.859 0.86 0.86 CASP9 IL10 MMP13 NFKB1 SLC6A3 STK11 0.829 0.9 0.86 0.87 CASP9 CCL27 GH1 SIRT1 SLC11A2 STK11 0.807 0.931 0.86 0.776 CASP1 IL10 IL1B NFKB1 NLRP1 STK11 0.809 0.927 0.86 0.813 CCL27 NLRP1 SDK1 SLC11A2 SMAD3 STK11 0.884 0.841 0.86 0.848 CCL27 IL6 NLRP1 SDK1 SIRT1 TNF 0.843 0.885 0.86 0.853 FKBP5 IGF1 IL10 NFKB1 STK11 VEGFA 0.842 0.884 0.86 0.838 FKBP5 IL10 MMP13 NFKB1 SLC6A3 STK11 0.854 0.87 0.86 0.874 CCL27 EPO MMP13 RGS2 SIRT1 SLC40A1 0.842 0.883 0.86 0.855 CD274 IL10 NFKB1 SLC6A3 STK11 TGFB1 0.845 0.886 0.86 0.845 HFE2 IL10 NFKB1 PAX8 PPARG STK11 0.817 0.913 0.86 0.817 CRHR1 MMP13 NLRP1 SLC11A2 SLC22A4 STK11 0.867 0.857 0.86 0.877 FKBP5 IL1B IL6 RGS2 SLC40A1 STK11 0.873 0.856 0.86 0.9 CCL27 HFE RGS2 SDK1 SLC40A1 VEGFA 0.758 1 0.86 0.79 CASP9 CCL27 NLRP1 RGS2 SLC40A1 STK11 0.824 0.912 0.86 0.846 IL6 RGS2 SDK1 SLC40A1 SLC6A3 STK11 0.831 0.899 0.86 0.861 ABCA1 CASP1 RGS2 SDK1 SLC40A1 STK11 0.842 0.884 0.86 0.871 ADAMTS4 CASP9 CCL27 RGS2 SLC40A1 STK11 0.814 0.914 0.86 0.841 CACNA1C CASP9 CCL27 RGS2 SLC40A1 STK11 0.814 0.914 0.86 0.834 CASP3 IL10 MUC1 NFKB1 SLC22A4 STK11 0.794 0.942 0.86 0.862 CRHR1 FKBP5 IL10 NFKB1 SLC11A2 STK11 0.838 0.885 0.86 0.853 FKBP5 IL10 NFKB1 NR3C1 STK11 VEGFA 0.818 0.913 0.86 0.824 ABCA1 IL10 IL1B MUC1 STK11 VEGFA 0.793 0.942 0.86 0.783 CASP9 NLRP1 RGS2 SDK1 SIRT1 STK11 0.841 0.885 0.86 0.856 CCL27 IL10 KRT1 NLRP1 SLC11A2 STK11 0.842 0.885 0.86 0.861 CCL27 IL1B IL6 MUC1 RGS2 SLC40A1 0.83 0.896 0.86 0.86 ABCA1 IL10 IL1B KRT83 MUC1 STK11 0.795 0.941 0.86 0.794 GCKR IL10 IL1A NFKB1 STK11 VEGFA 0.803 0.928 0.86 0.816 HAMP HFE IL10 SLC11A2 SLC22A4 STK11 0.807 0.928 0.86 0.838 CASP3 CASP9 FKBP5 IL10 NR3C1 STK11 0.811 0.929 0.86 0.809 CASP3 CASP9 IL10 NR3C1 RGS2 STK11 0.811 0.929 0.86 0.829 CACNA1C CASP9 FGFR2 RGS2 SLC40A1 STK11 0.815 0.913 0.86 0.823 ADAMTS4 IL10 NFKB1 NFKB2 SLC11A2 STK11 0.843 0.886 0.86 0.83 CACNA1C EPO IL10 NFKB1 SLC11A2 STK11 0.843 0.886 0.86 0.849 CASP9 FGFR2 IL10 NFKB1 STK11 TGFB1 0.841 0.886 0.86 0.856 CASP9 IL10 NFKB1 PAX8 STK11 TGFB1 0.841 0.886 0.86 0.853 IL10 NFKB2 SDK1 SLC11A2 STK11 VEGFA 0.839 0.886 0.86 0.85 EPO HAMP IL10 IL1A NFKB1 STK11 0.805 0.928 0.86 0.823 IL1B IL6 KRT83 RGS2 SDK1 SLC40A1 0.773 0.971 0.86 0.819 CASP9 HAMP HFE IL10 NLRP3 STK11 0.829 0.902 0.86 0.847 ADAMTS4 EPO IL10 NFKB1 PAX8 STK11 0.818 0.914 0.86 0.839 ADAMTS4 IL10 NFKB1 PAX8 STK11 VEGFA 0.817 0.913 0.86 0.837 CD274 IGF1 IL10 NFKB1 PAX8 STK11 0.817 0.913 0.86 0.84 EPO IGF1 IL10 NFKB1 PAX8 STK11 0.817 0.913 0.86 0.84 CD274 IL10 MMP13 NLRP1 PPARG STK11 0.804 0.929 0.86 0.845 CASP9 GCKR IL10 IL6 NFKB1 STK11 0.849 0.886 0.86 0.856 ABCA1 CACNA1C CASP9 RGS2 SLC40A1 STK11 0.815 0.914 0.86 0.825 CACNA1C CASP9 EDAR RGS2 SLC40A1 STK11 0.815 0.914 0.86 0.825 CACNA1C CASP9 KRT83 RGS2 SLC40A1 STK11 0.815 0.914 0.86 0.837 CACNA1C CASP9 RGS2 SLC22A4 SLC40A1 STK11 0.815 0.914 0.86 0.825 CASP9 EDAR KRT83 RGS2 SLC40A1 STK11 0.815 0.914 0.86 0.832 GCKR GH1 IL10 MUC1 NFKB2 STK11 0.804 0.928 0.86 0.828 CASP3 CASP9 EPO RGS2 SLC40A1 STK11 0.816 0.913 0.86 0.843 CCL27 HFE MMP13 NLRP1 SLC11A2 STK11 0.869 0.855 0.86 0.859 HAMP IL10 NLRP1 SLC11A2 SLC22A4 STK11 0.805 0.928 0.86 0.849 CASP9 EPO MMP13 NLRP1 SLC22A4 STK11 0.871 0.856 0.86 0.871 CASP9 MMP13 NLRP1 SLC22A4 STK11 VEGFA 0.871 0.856 0.86 0.86 CASP9 CCL27 RGS2 SDK1 SLC40A1 STK11 0.823 0.913 0.86 0.869 CASP9 MUC1 NLRP1 NR3C1 STK11 TNF 0.809 0.927 0.86 0.794 CRHR1 HFE IL10 MMP13 NFKB1 SIRT1 0.869 0.857 0.86 0.868 CASP9 HFE2 IL10 NFKB1 SIRT1 STK11 0.843 0.886 0.86 0.881 IL10 MMP13 NFKB1 SLC40A1 STK11 VEGFA 0.839 0.885 0.86 0.851 GCKR IL10 NFKB1 RGS2 SDK1 STK11 0.856 0.87 0.86 0.851 HFE IL10 NFKB2 SLC11A2 STK11 VEGFA 0.833 0.902 0.86 0.847 IL1B MMP13 RGS2 SDK1 SLC40A1 SMAD3 0.807 0.927 0.86 0.86 IL6 MMP13 NLRP1 PPARG SMAD3 STK11 0.89 0.841 0.86 0.829 CASP9 CRHR1 IL10 NFKB1 STK11 TGFB1 0.846 0.886 0.86 0.867 FGFR2 IL10 NFKB1 NFKB2 SLC11A2 STK11 0.843 0.885 0.86 0.856 ABCA1 HFE MMP13 MUC1 SLC22A4 STK11 0.803 0.927 0.86 0.843 HFE IL6 MMP13 NFKB1 SLC6A3 STK11 0.868 0.854 0.86 0.865 CASP9 CRHR1 HFE MMP13 SLC40A1 STK11 0.841 0.886 0.859 0.841 HFE IL10 MUC1 RGS2 SDK1 SLC40A1 0.775 0.971 0.859 0.799 CRHR1 MMP13 MUC1 NLRP1 SDK1 SIRT1 0.83 0.899 0.859 0.849 CCL27 RGS2 SDK1 SIRT1 SLC40A1 TNF 0.794 0.941 0.859 0.843 CD274 GH1 IL10 NFKB1 STK11 TGFB1 0.82 0.915 0.859 0.838 IL6 MMP13 MUC1 NLRP1 SDK1 STK11 0.875 0.855 0.859 0.872 CASP3 CCL27 IL10 MUC1 NFKB1 STK11 0.803 0.928 0.859 0.865 EDAR HAMP HFE IL10 NFKB1 STK11 0.84 0.884 0.859 0.826 IL1B MMP13 PAX8 RGS2 SDK1 SLC40A1 0.821 0.914 0.859 0.857 FGFR2 HFE2 IL10 NFKB1 PAX8 STK11 0.821 0.913 0.859 0.851 CASP3 IL10 IL6 MUC1 NFKB1 STK11 0.804 0.928 0.859 0.871 CASP3 IL10 KRT1 MUC1 NFKB1 STK11 0.804 0.928 0.859 0.849 HFE IL10 MMP13 NFKB2 RGS2 STK11 0.883 0.842 0.859 0.872 CASP9 EPO KRT83 RGS2 SLC40A1 STK11 0.815 0.913 0.859 0.844 HAMP IL10 NFKB1 SDK1 STK11 TGFB1 0.837 0.886 0.859 0.833 CASP9 CD274 HFE IL10 NFKB1 STK11 0.814 0.914 0.859 0.867 IL10 IL1A MUC1 NFKB2 NR3C1 STK11 0.803 0.927 0.859 0.816 GCKR HAMP IL10 NFKB1 SLC6A3 STK11 0.8 0.928 0.859 0.853 CASP9 GCKR IL10 NFKB1 STK11 TGFB1 0.838 0.886 0.859 0.865 CACNA1C MMP13 MUC1 NLRP1 SDK1 STK11 0.873 0.855 0.859 0.878 GH1 HAMP IL10 STK11 TGFB1 TNF 0.82 0.915 0.859 0.819 CASP3 IL10 MUC1 NFKB1 SMAD3 STK11 0.806 0.929 0.859 0.854 HAMP IL10 MMP13 RGS2 SLC22A4 STK11 0.842 0.885 0.859 0.861 CASP9 FKBP5 IL10 IL6 NFKB1 STK11 0.839 0.885 0.859 0.851 FGFR2 MMP13 NLRP1 RGS2 SLC11A2 STK11 0.888 0.84 0.859 0.863 CCL27 HFE IL1B RGS2 SDK1 SLC40A1 0.772 0.971 0.859 0.826 IL10 KRT1 NFKB1 NLRP3 STK11 TGFB1 0.85 0.886 0.859 0.845 CD274 IL10 NFKB1 NLRP1 PAX8 STK11 0.814 0.913 0.859 0.855 HAMP IL10 PAX8 SLC11A2 SLC22A4 STK11 0.805 0.929 0.859 0.821 CASP9 HFE IL6 NLRP1 SLC11A2 STK11 0.826 0.899 0.859 0.874 CCL27 HAMP IL10 NFKB1 PAX8 STK11 0.855 0.869 0.859 0.847 GCKR IL10 NFKB2 SDK1 SLC11A2 STK11 0.842 0.888 0.859 0.85 CCL27 RGS2 SDK1 SLC40A1 SMAD3 STK11 0.821 0.912 0.859 0.883 CASP9 FKBP5 HFE2 IL10 NFKB1 STK11 0.855 0.871 0.859 0.856 CASP3 CASP9 CCL27 HAMP IL10 STK11 0.826 0.902 0.859 0.855 CACNA1C CASP9 RGS2 SLC11A2 SLC40A1 STK11 0.826 0.9 0.859 0.823 CASP3 CASP9 IL10 NFKB1 SKA2 STK11 0.856 0.871 0.859 0.842 CASP9 HFE2 IL6 MMP13 SLC40A1 STK11 0.891 0.845 0.859 0.852 FKBP5 NLRP1 PPARG SIRT1 SLC11A2 STK11 0.837 0.886 0.859 0.85 HAMP IL10 KRT1 NFKB2 SLC11A2 STK11 0.803 0.931 0.859 0.817 CASP9 MMP13 NLRP1 PAX8 SLC22A4 STK11 0.884 0.842 0.859 0.864 ADAMTS4 HFE IL10 MUC1 NFKB1 STK11 0.826 0.896 0.859 0.862 GH1 HFE IL10 MUC1 NFKB1 STK11 0.826 0.896 0.859 0.85 CASP9 HFE IL10 MMP13 NFKB1 STK11 0.879 0.841 0.859 0.877 FKBP5 HFE IGF1 IL10 NFKB1 STK11 0.838 0.884 0.859 0.852 CCL27 HFE IL10 MUC1 NLRP1 STK11 0.827 0.899 0.859 0.855 EPO HAMP IL10 MUC1 NLRP1 STK11 0.827 0.899 0.859 0.844 CASP1 IL10 NFKB1 SDK1 SIRT1 SLC40A1 0.802 0.928 0.859 0.829 CRHR1 NLRP3 RGS2 SDK1 SKA2 SLC40A1 0.756 1 0.859 0.822 CASP9 HFE MMP13 MUC1 SLC22A4 STK11 0.813 0.913 0.859 0.845 CASP3 IL10 NFKB2 SLC11A2 STK11 VEGFA 0.844 0.888 0.859 0.862 FKBP5 HFE IL10 NFKB1 STK11 TGFB1 0.84 0.885 0.859 0.863 CASP9 CCL27 PPARG RGS2 SLC40A1 STK11 0.794 0.942 0.859 0.83 CACNA1C FKBP5 HFE2 IL10 NFKB1 STK11 0.84 0.883 0.859 0.861 CASP9 EDAR MMP13 MUC1 NLRP1 STK11 0.838 0.885 0.859 0.846 ABCA1 CASP9 HFE2 RGS2 SLC40A1 STK11 0.829 0.899 0.859 0.83 CD274 CRHR1 IL10 NFKB1 PAX8 STK11 0.813 0.913 0.859 0.842 CASP9 IL10 NLRP1 NR3C1 SMAD3 STK11 0.816 0.914 0.859 0.822 CACNA1C GH1 IL10 MMP13 NFKB1 STK11 0.852 0.87 0.859 0.861 ABCA1 HFE IL6 NR3C1 STK11 TGFB1 0.804 0.927 0.859 0.798 CASP1 NLRP1 SIRT1 SLC11A2 SLC40A1 STK11 0.838 0.885 0.859 0.846 FKBP5 NLRP1 SIRT1 SLC11A2 STK11 VEGFA 0.841 0.885 0.859 0.857 EPO IL10 MMP13 NFKB1 NLRP1 STK11 0.853 0.871 0.859 0.854 FGFR2 IL10 NFKB1 NLRP3 SLC11A2 STK11 0.842 0.884 0.859 0.829 CASP1 HFE2 IL10 NFKB1 PAX8 STK11 0.818 0.912 0.859 0.836 CASP9 FKBP5 RGS2 SLC22A4 SLC40A1 STK11 0.793 0.942 0.859 0.844 CASP9 IL10 NLRP1 NR3C1 STK11 TGFB1 0.818 0.914 0.859 0.87 CASP9 CD274 GCKR IL10 MMP13 STK11 0.845 0.888 0.859 0.864 GCKR IL10 IL1A KRT1 NFKB1 STK11 0.8 0.928 0.859 0.816 CCL27 MUC1 RGS2 SDK1 SLC40A1 TNF 0.778 0.97 0.859 0.78 EPO HFE IL10 IL6 NFKB1 STK11 0.84 0.885 0.859 0.855 CCL27 GCKR MUC1 NLRP1 STK11 TGFB1 0.815 0.913 0.859 0.811 CCL27 RGS2 SDK1 SIRT1 SLC11A2 SLC40A1 0.806 0.927 0.859 0.847 CASP1 IL10 NFKB1 NLRP1 SLC6A3 STK11 0.816 0.913 0.859 0.836 ABCA1 CASP9 HFE IL10 NFKB1 STK11 0.8 0.928 0.859 0.85 CD274 IL10 NFKB2 PAX8 SLC11A2 STK11 0.802 0.929 0.859 0.845 HFE IL6 MMP13 NFKB1 STK11 VEGFA 0.872 0.852 0.859 0.879 IL10 IL1B MUC1 NFKB1 SLC40A1 STK11 0.804 0.928 0.859 0.853 CASP1 HAMP IL10 MUC1 NFKB2 STK11 0.799 0.928 0.859 0.831 CASP9 CCL27 NFKB2 RGS2 SLC40A1 STK11 0.812 0.913 0.859 0.836 CASP9 IL10 NFKB1 STK11 TGFB1 TNF 0.816 0.914 0.859 0.836 FKBP5 HAMP IL10 MUC1 NFKB2 STK11 0.799 0.928 0.859 0.854 CASP9 IL10 NFKB1 NLRP1 STK11 TGFB1 0.857 0.871 0.859 0.862 CASP9 RGS2 SLC11A2 SLC22A4 SLC40A1 STK11 0.792 0.942 0.859 0.829 CASP9 IL10 KRT1 NFKB1 SLC11A2 STK11 0.813 0.914 0.859 0.842 CASP1 MMP13 MUC1 NLRP1 SDK1 STK11 0.918 0.826 0.859 0.876 CASP9 FKBP5 RGS2 SDK1 SLC40A1 STK11 0.816 0.914 0.859 0.832 EDAR IL10 MUC1 NFKB2 STK11 VEGFA 0.802 0.928 0.859 0.797 HAMP IL10 NLRP1 SKA2 SLC11A2 STK11 0.802 0.928 0.859 0.838 IL10 MUC1 NFKB1 SKA2 SLC40A1 STK11 0.803 0.927 0.859 0.844 IL10 MUC1 NFKB1 NR3C1 SIRT1 TGFB1 0.772 0.971 0.859 0.767 HFE NFKB2 SIRT1 SLC11A2 STK11 VEGFA 0.802 0.928 0.859 0.834 CASP3 HAMP IL10 NLRP1 SLC11A2 STK11 0.801 0.928 0.859 0.845 HAMP IL10 NFKB1 NR3C1 PPARG STK11 0.813 0.914 0.859 0.803 CASP3 CASP9 MMP13 NLRP1 SLC22A4 STK11 0.892 0.841 0.859 0.856 IL10 NFKB2 SKA2 SLC11A2 STK11 TGFB1 0.863 0.872 0.859 0.855 EPO IL10 MMP13 NFKB1 SIRT1 STK11 0.884 0.842 0.859 0.872 IL18 MUC1 NLRP1 PAX8 SLC6A3 STK11 0.804 0.927 0.859 0.795 ABCA1 HAMP IL10 MUC1 NLRP1 STK11 0.826 0.898 0.859 0.821 HAMP IL10 MUC1 NLRP1 PAX8 STK11 0.826 0.898 0.859 0.833 RGS2 SDK1 SIRT1 SKA2 SLC22A4 SLC40A1 0.806 0.927 0.859 0.829 CASP1 IL10 KRT1 MUC1 NFKB1 STK11 0.802 0.927 0.859 0.839 CASP9 CD274 IL10 NFKB1 SKA2 STK11 0.852 0.872 0.859 0.86 FKBP5 IL10 NFKB1 NLRP3 SLC40A1 STK11 0.805 0.927 0.859 0.857 IL10 RGS2 SKA2 SLC40A1 STK11 VEGFA 0.802 0.926 0.859 0.873 CASP1 IL10 IL1A NFKB1 SLC40A1 STK11 0.839 0.886 0.859 0.866 CASP1 IL10 MMP13 NFKB1 SLC6A3 STK11 0.836 0.885 0.859 0.877 CD274 IL10 IL1A NFKB1 SLC6A3 STK11 0.839 0.886 0.859 0.843 CRHR1 IL10 IL18 MUC1 NFKB1 STK11 0.801 0.928 0.859 0.832 CASP9 CCL27 MUC1 NLRP1 SDK1 STK11 0.847 0.884 0.859 0.848 EPO IL10 MMP13 NFKB1 STK11 VEGFA 0.851 0.871 0.859 0.849 GH1 HAMP IL10 NFKB1 SDK1 STK11 0.85 0.87 0.859 0.852 CASP1 FKBP5 IL10 NFKB1 SLC40A1 STK11 0.811 0.914 0.859 0.867 CRHR1 IGF1 IL10 MUC1 NFKB1 STK11 0.803 0.927 0.859 0.845 GCKR IL10 IL18 MUC1 NFKB2 STK11 0.814 0.914 0.859 0.835 IL10 MMP13 NFKB1 NFKB2 SIRT1 STK11 0.885 0.843 0.859 0.866 IL10 IL1A MUC1 NFKB1 SLC6A3 STK11 0.801 0.927 0.859 0.879 CCL27 IL10 IL18 NFKB1 PAX8 STK11 0.823 0.9 0.859 0.825 ABCA1 CASP9 FKBP5 MMP13 MUC1 STK11 0.812 0.914 0.859 0.801 HAMP IL10 MUC1 NFKB2 NLRP1 STK11 0.826 0.898 0.859 0.825 ABCA1 IL10 IL1B MUC1 SLC6A3 STK11 0.805 0.928 0.859 0.8 IL10 NFKB1 RGS2 SIRT1 SKA2 SLC40A1 0.803 0.928 0.859 0.854 IL1B NLRP1 SLC11A2 SLC6A3 STK11 VEGFA 0.784 0.957 0.859 0.771 EPO IL10 MMP13 NFKB1 SLC22A4 STK11 0.85 0.871 0.859 0.856 CASP3 HFE IL10 NFKB1 SLC11A2 STK11 0.85 0.871 0.859 0.839 CASP9 CCL27 HFE2 RGS2 SLC40A1 STK11 0.815 0.912 0.859 0.851 CACNA1C CASP9 IL6 MMP13 SLC40A1 STK11 0.867 0.874 0.859 0.858 HAMP IL10 NFKB1 NLRP1 SLC11A2 STK11 0.815 0.914 0.859 0.837 GCKR IL1A MUC1 NLRP1 NLRP3 STK11 0.803 0.927 0.859 0.79 CCL27 FGFR2 RGS2 SLC40A1 STK11 VEGFA 0.827 0.898 0.858 0.816 CASP9 HAMP IL10 NFKB2 STK11 TGFB1 0.813 0.915 0.858 0.854 IL6 NFKB2 RGS2 SLC40A1 STK11 TGFB1 0.85 0.871 0.858 0.872 CASP1 EPO IL10 NFKB1 PAX8 STK11 0.815 0.914 0.858 0.843 HFE2 IL10 NFKB1 PAX8 SMAD3 STK11 0.815 0.912 0.858 0.846 EPO IL10 NFKB1 NLRP1 NR3C1 STK11 0.783 0.956 0.858 0.779 HAMP IL10 IL1A NLRP1 SLC11A2 STK11 0.841 0.885 0.858 0.845 CASP3 CCL27 HFE RGS2 SDK1 SLC40A1 0.798 0.943 0.858 0.828 ABCA1 SDK1 SIRT1 SLC11A2 STK11 VEGFA 0.803 0.928 0.858 0.85 CASP1 HAMP IL10 NFKB1 PAX8 STK11 0.826 0.899 0.858 0.849 HAMP IL10 NFKB1 PAX8 STK11 VEGFA 0.826 0.899 0.858 0.847 ABCA1 GH1 IL10 IL1B MUC1 STK11 0.793 0.941 0.858 0.797 CASP9 EPO RGS2 SLC40A1 SLC6A3 STK11 0.792 0.942 0.858 0.839 FGFR2 HFE IL10 MUC1 NFKB1 STK11 0.838 0.883 0.858 0.851 CCL27 HFE MMP13 RGS2 SDK1 SLC40A1 0.799 0.942 0.858 0.84 FKBP5 MMP13 NFKB1 RGS2 SIRT1 SLC40A1 0.804 0.927 0.858 0.825 ADAMTS4 CASP9 FGFR2 IL10 NFKB1 STK11 0.828 0.9 0.858 0.844 CCL27 HAMP MUC1 NLRP1 SDK1 STK11 0.847 0.883 0.858 0.843 CASP1 HAMP IL10 RGS2 STK11 TGFB1 0.82 0.917 0.858 0.841 CCL27 IGF1 IL10 NFKB1 SLC6A3 STK11 0.844 0.885 0.858 0.861 CASP9 IL10 IL1B MMP13 NLRP1 STK11 0.888 0.842 0.858 0.869 CASP9 HAMP IL10 NLRP1 RGS2 STK11 0.818 0.913 0.858 0.883 HFE2 IL10 MUC1 NFKB1 STK11 TGFB1 0.809 0.928 0.858 0.852 CCL27 MMP13 MUC1 NLRP1 RGS2 STK11 0.895 0.838 0.858 0.874 GCKR IL10 MMP13 NLRP1 SLC11A2 STK11 0.839 0.885 0.858 0.872 HFE NLRP3 RGS2 SDK1 SKA2 SLC40A1 0.768 0.985 0.858 0.794 IL10 MUC1 NFKB2 NLRP1 STK11 VEGFA 0.802 0.927 0.858 0.821 CASP1 IL10 IL6 MUC1 NFKB1 STK11 0.801 0.927 0.858 0.835 CASP9 EPO IL10 NFKB1 STK11 TNF 0.814 0.914 0.858 0.828 CD274 IL10 MUC1 NFKB1 STK11 TGFB1 0.802 0.928 0.858 0.862 HAMP IL10 NFKB1 SKA2 SLC6A3 STK11 0.811 0.914 0.858 0.849 IL10 MMP13 NFKB1 NFKB2 PAX8 STK11 0.897 0.828 0.858 0.842 CRHR1 HFE2 IL10 MMP13 NFKB1 SIRT1 0.842 0.886 0.858 0.856 CCL27 RGS2 SDK1 SLC11A2 SLC40A1 STK11 0.831 0.899 0.858 0.853 HAMP IL10 MUC1 NLRP1 RGS2 STK11 0.826 0.898 0.858 0.847 CASP3 CASP9 IL10 NFKB1 NR3C1 STK11 0.819 0.914 0.858 0.833 HFE2 IL10 MUC1 NFKB1 SLC40A1 STK11 0.802 0.926 0.858 0.849 CASP9 FKBP5 IL6 RGS2 SLC40A1 STK11 0.827 0.899 0.858 0.868 HFE IL10 NFKB1 NFKB2 SLC11A2 STK11 0.848 0.871 0.858 0.835 CACNA1C GH1 IL10 MUC1 NFKB2 STK11 0.801 0.927 0.858 0.814 CACNA1C IL10 KRT83 MUC1 NFKB2 STK11 0.801 0.927 0.858 0.805 CD274 IL10 IL6 NFKB2 SLC11A2 STK11 0.816 0.915 0.858 0.826 ABCA1 CASP9 HFE MMP13 MUC1 STK11 0.811 0.913 0.858 0.836 ABCA1 IL10 KRT83 MUC1 NFKB1 STK11 0.801 0.926 0.858 0.835 GCKR IL10 MUC1 NLRP1 RGS2 STK11 0.826 0.898 0.858 0.827 IL1B IL6 RGS2 SIRT1 SLC40A1 STK11 0.882 0.84 0.858 0.866 IL10 MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.783 0.957 0.858 0.791 IL18 IL6 MUC1 NFKB1 NLRP1 STK11 0.816 0.913 0.858 0.808 FGFR2 IL10 MMP13 NFKB1 SMAD3 STK11 0.85 0.87 0.858 0.864 CASP9 EPO HFE2 RGS2 SLC40A1 STK11 0.827 0.899 0.858 0.837 ADAMTS4 IL10 MUC1 NFKB1 SLC6A3 STK11 0.8 0.927 0.858 0.866 CASP1 IL10 MUC1 NFKB1 SLC6A3 STK11 0.8 0.927 0.858 0.855 FGFR2 IL10 MUC1 NFKB1 SLC6A3 STK11 0.8 0.927 0.858 0.86 IL10 MUC1 NFKB1 NFKB2 SLC6A3 STK11 0.8 0.927 0.858 0.862 IL10 MUC1 NFKB1 RGS2 SLC6A3 STK11 0.8 0.927 0.858 0.86 ADAMTS4 MMP13 NLRP1 RGS2 SLC11A2 STK11 0.903 0.827 0.858 0.854 CASP9 HFE MMP13 NLRP1 SLC40A1 STK11 0.881 0.841 0.858 0.862 ABCA1 IL10 NFKB1 NLRP3 SKA2 STK11 0.813 0.914 0.858 0.828 ABCA1 CASP1 IL10 MMP13 NFKB1 STK11 0.811 0.913 0.858 0.857 CCL27 CRHR1 IL1B MMP13 RGS2 SLC40A1 0.811 0.913 0.858 0.856 CRHR1 GCKR IL1B MMP13 RGS2 SLC40A1 0.811 0.913 0.858 0.874 CCL27 HFE MUC1 NR3C1 SLC22A4 SLC40A1 0.788 0.955 0.858 0.764 CD274 IL10 NFKB1 PAX8 STK11 TGFB1 0.855 0.872 0.858 0.849 ADAMTS4 IL10 MMP13 NLRP1 SMAD3 STK11 0.848 0.886 0.858 0.86 CCL27 FGFR2 RGS2 SDK1 SLC40A1 STK11 0.816 0.912 0.858 0.84 CASP9 GCKR HAMP IL10 SLC22A4 STK11 0.814 0.915 0.858 0.861 CCL27 GCKR MUC1 NLRP1 SDK1 STK11 0.857 0.869 0.858 0.853 ADAMTS4 CCL27 IL10 NFKB1 PAX8 STK11 0.851 0.871 0.858 0.837 IL10 NFKB2 RGS2 SLC11A2 STK11 VEGFA 0.852 0.872 0.858 0.843 IL10 RGS2 SKA2 SLC40A1 STK11 TGFB1 0.888 0.843 0.858 0.876 CASP3 IL10 IL6 NFKB1 SLC11A2 STK11 0.813 0.913 0.858 0.842 HAMP IL10 NFKB1 RGS2 SLC11A2 STK11 0.81 0.914 0.858 0.848 CD274 HFE IL10 NFKB1 PAX8 STK11 0.849 0.87 0.858 0.841 CACNA1C IL10 NFKB2 SIRT1 SLC11A2 STK11 0.828 0.902 0.858 0.835 ABCA1 IL10 MUC1 NFKB1 STK11 TNF 0.8 0.926 0.858 0.818 IL10 MUC1 NFKB1 SLC22A4 STK11 TGFB1 0.8 0.928 0.858 0.854 CASP1 FKBP5 IL10 NFKB1 SLC11A2 STK11 0.853 0.87 0.858 0.841 FKBP5 IGF1 IL10 NFKB1 SLC11A2 STK11 0.853 0.87 0.858 0.821 MUC1 NLRP3 NR3C1 RGS2 STK11 TNF 0.78 0.956 0.858 0.706 CASP9 GH1 IL10 MMP13 NLRP1 STK11 0.876 0.857 0.858 0.845 CASP1 IL10 MMP13 NFKB1 NLRP1 STK11 0.832 0.898 0.858 0.851 ABCA1 IL10 IL6 MUC1 NFKB1 STK11 0.799 0.926 0.858 0.851 CASP9 IL10 IL6 NFKB1 PPARG STK11 0.812 0.914 0.858 0.843 EPO IL10 MMP13 NFKB2 STK11 TGFB1 0.853 0.872 0.858 0.843 CCL27 IL10 MUC1 NFKB1 SMAD3 STK11 0.811 0.913 0.858 0.851 CRHR1 IL10 IL1A KRT1 NFKB1 STK11 0.812 0.915 0.858 0.836 EPO IL10 KRT1 NFKB1 SLC11A2 STK11 0.813 0.914 0.858 0.819 CCL27 MMP13 NLRP1 RGS2 SDK1 STK11 0.895 0.84 0.858 0.875 ABCA1 ADAMTS4 IL10 MUC1 NFKB1 STK11 0.8 0.926 0.858 0.84 CD274 IL10 MUC1 NFKB2 SLC22A4 STK11 0.801 0.927 0.858 0.826 CCL27 RGS2 SIRT1 SLC40A1 SLC6A3 TGFB1 0.812 0.913 0.858 0.839 EPO MUC1 NR3C1 SLC40A1 STK11 TNF 0.792 0.942 0.858 0.767 CASP3 IL10 MUC1 NFKB1 NFKB2 STK11 0.801 0.928 0.858 0.844 CRHR1 EPO IL1B MMP13 RGS2 SLC40A1 0.816 0.913 0.858 0.846 IL10 IL6 NFKB2 PAX8 SLC11A2 STK11 0.816 0.915 0.858 0.845 CCL27 MUC1 NLRP1 SLC22A4 STK11 TGFB1 0.813 0.913 0.858 0.819 CRHR1 IL10 MUC1 SDK1 SLC22A4 SLC6A3 0.778 0.957 0.858 0.805 FGFR2 HFE IL1B MMP13 RGS2 SLC40A1 0.78 0.956 0.858 0.838 IGF1 IL10 MUC1 NFKB2 SIRT1 STK11 0.781 0.957 0.858 0.776 CASP1 FKBP5 IL10 NFKB1 STK11 VEGFA 0.858 0.869 0.858 0.842 IL10 MMP13 NFKB1 NLRP1 SMAD3 STK11 0.855 0.87 0.857 0.869 CRHR1 IL10 MMP13 NFKB1 STK11 TGFB1 0.847 0.872 0.857 0.87 CCL27 IL18 IL6 SLC11A2 SLC40A1 STK11 0.84 0.885 0.857 0.834 ADAMTS4 CCL27 MMP13 RGS2 SDK1 SLC40A1 0.778 0.971 0.857 0.825 CCL27 FGFR2 MMP13 RGS2 SDK1 SLC40A1 0.778 0.971 0.857 0.814 CCL27 IL1A MMP13 RGS2 SDK1 SLC40A1 0.778 0.971 0.857 0.816 CCL27 MMP13 NFKB1 RGS2 SDK1 SLC40A1 0.778 0.971 0.857 0.817 ABCA1 IL6 RGS2 SLC40A1 STK11 TGFB1 0.847 0.871 0.857 0.87 CD274 IL6 RGS2 SLC40A1 STK11 TGFB1 0.847 0.871 0.857 0.879 CRHR1 IL10 MMP13 NFKB1 NLRP1 STK11 0.861 0.857 0.857 0.857 EDAR IL6 RGS2 SLC40A1 STK11 TGFB1 0.847 0.871 0.857 0.872 FKBP5 IL6 RGS2 SLC40A1 STK11 TGFB1 0.847 0.871 0.857 0.879 GH1 IL6 RGS2 SLC40A1 STK11 TGFB1 0.847 0.871 0.857 0.875 HFE2 IL6 RGS2 SLC40A1 STK11 TGFB1 0.847 0.871 0.857 0.876 IL6 KRT83 RGS2 SLC40A1 STK11 TGFB1 0.847 0.871 0.857 0.867 IL6 RGS2 SLC11A2 SLC40A1 STK11 TGFB1 0.847 0.871 0.857 0.884 IL6 RGS2 SLC40A1 STK11 TGFB1 VEGFA 0.847 0.871 0.857 0.878 CASP9 IL10 NFKB1 RGS2 SLC40A1 STK11 0.824 0.899 0.857 0.857 EDAR HAMP IL10 NFKB1 PAX8 STK11 0.822 0.899 0.857 0.833 CCL27 MMP13 RGS2 SDK1 SLC40A1 TNF 0.766 0.985 0.857 0.814 HAMP IL10 SIRT1 STK11 TGFB1 TNF 0.829 0.902 0.857 0.819 HFE IL10 KRT1 NFKB1 SLC6A3 STK11 0.809 0.914 0.857 0.847 CACNA1C GCKR MUC1 NFKB2 NR3C1 STK11 0.782 0.955 0.857 0.764 FKBP5 GCKR MUC1 NFKB2 NR3C1 STK11 0.782 0.955 0.857 0.757 GCKR HAMP MUC1 NFKB1 NR3C1 STK11 0.782 0.955 0.857 0.734 GCKR MUC1 NFKB1 NFKB2 NR3C1 STK11 0.782 0.955 0.857 0.729 NLRP1 PPARG SIRT1 SLC11A2 STK11 TGFB1 0.836 0.884 0.857 0.841 CASP9 KRT1 MMP13 NLRP1 RGS2 STK11 0.9 0.826 0.857 0.889 CACNA1C HFE IL6 MMP13 NFKB1 STK11 0.884 0.838 0.857 0.886 CCL27 IL10 RGS2 SIRT1 SKA2 SLC40A1 0.851 0.869 0.857 0.862 CACNA1C IL10 NFKB1 NR3C1 PAX8 STK11 0.793 0.942 0.857 0.819 CASP1 IL10 NFKB1 NR3C1 PAX8 STK11 0.793 0.942 0.857 0.803 CASP9 CCL27 FKBP5 SIRT1 SLC11A2 STK11 0.834 0.9 0.857 0.813 CCL27 HAMP IL10 MUC1 NLRP1 SLC11A2 0.779 0.956 0.857 0.831 HFE IL6 RGS2 SDK1 SKA2 SLC40A1 0.765 0.985 0.857 0.755 CD274 IL10 MUC1 NFKB2 STK11 TNF 0.779 0.957 0.857 0.82 ABCA1 CASP9 FKBP5 HFE MMP13 STK11 0.836 0.884 0.857 0.827 IL10 NFKB1 SLC11A2 SMAD3 STK11 TGFB1 0.828 0.902 0.857 0.851 IL10 IL1A NFKB1 SIRT1 SLC6A3 STK11 0.815 0.914 0.857 0.839 ABCA1 HFE IL1B MMP13 RGS2 SLC40A1 0.779 0.956 0.857 0.835 FGFR2 NLRP1 RGS2 SLC11A2 SLC40A1 STK11 0.789 0.942 0.857 0.833 IL10 NLRP1 NR3C1 SMAD3 STK11 TGFB1 0.791 0.943 0.857 0.821 CASP9 FKBP5 IL10 NFKB1 STK11 TGFB1 0.85 0.872 0.857 0.865 CASP9 IGF1 IL6 SLC6A3 STK11 TGFB1 0.851 0.871 0.857 0.829 IL10 IL6 NFKB2 SLC11A2 STK11 TGFB1 0.852 0.872 0.857 0.844 CACNA1C CASP9 CD274 MMP13 SLC11A2 STK11 0.836 0.888 0.857 0.839 CRHR1 GH1 HFE IL10 NFKB1 STK11 0.85 0.87 0.857 0.865 IL10 NFKB2 PAX8 SKA2 SLC11A2 STK11 0.854 0.872 0.857 0.841 CCL27 KRT83 RGS2 SIRT1 SLC22A4 TGFB1 0.8 0.927 0.857 0.803 CRHR1 IL10 MUC1 NFKB1 STK11 TGFB1 0.811 0.914 0.857 0.863 CACNA1C HAMP IL10 NLRP1 SKA2 STK11 0.777 0.957 0.857 0.792 IL10 IL6 NFKB1 NR3C1 PAX8 STK11 0.796 0.941 0.857 0.814 ADAMTS4 GCKR IL10 MMP13 NFKB1 STK11 0.863 0.857 0.857 0.858 CCL27 GCKR IL10 MMP13 NFKB1 STK11 0.863 0.857 0.857 0.858 GCKR IL10 MMP13 NFKB1 SLC22A4 STK11 0.863 0.857 0.857 0.856 GH1 IL10 MMP13 NFKB1 SIRT1 STK11 0.901 0.828 0.857 0.877 CASP9 CD274 IL10 NFKB1 NLRP1 STK11 0.809 0.913 0.857 0.868 GH1 IL10 NFKB1 NLRP3 SLC11A2 STK11 0.813 0.914 0.857 0.81 HAMP IL10 NFKB2 NLRP1 SLC11A2 STK11 0.808 0.914 0.857 0.837 CCL27 EPO MMP13 RGS2 SDK1 SLC40A1 0.776 0.971 0.857 0.814 EPO IL10 NFKB1 NLRP3 PAX8 STK11 0.827 0.898 0.857 0.84 CASP1 IL10 MUC1 NFKB1 NLRP1 STK11 0.839 0.883 0.857 0.854 NFKB1 NLRP3 RGS2 SDK1 SKA2 SLC40A1 0.762 0.986 0.857 0.782 NFKB2 NLRP3 RGS2 SDK1 SKA2 SLC40A1 0.762 0.986 0.857 0.794 CACNA1C MMP13 NLRP1 RGS2 SMAD3 STK11 0.904 0.824 0.857 0.862 HFE IL10 NFKB1 NLRP1 RGS2 STK11 0.834 0.898 0.857 0.878 CASP1 HAMP IL10 NFKB1 NLRP3 STK11 0.811 0.914 0.857 0.844 CASP3 CASP9 EPO IL10 NFKB1 STK11 0.811 0.914 0.857 0.858 HAMP IL10 MUC1 NFKB2 NLRP3 STK11 0.807 0.914 0.857 0.833 HAMP IL10 MUC1 NFKB2 PAX8 STK11 0.807 0.914 0.857 0.862 HAMP IL10 NFKB1 NLRP3 STK11 VEGFA 0.811 0.914 0.857 0.853 IL10 MUC1 NFKB1 SMAD3 STK11 VEGFA 0.81 0.913 0.857 0.853 ADAMTS4 HFE IL10 IL6 NFKB1 STK11 0.848 0.87 0.857 0.857 CASP1 IL10 NFKB1 SKA2 SLC40A1 STK11 0.849 0.871 0.857 0.857 CASP3 HFE IL10 IL6 NFKB1 STK11 0.848 0.87 0.857 0.855 HFE IL10 IL6 NFKB1 NLRP3 STK11 0.848 0.87 0.857 0.853 HFE IL10 IL6 NFKB1 PAX8 STK11 0.848 0.87 0.857 0.859 IL10 MMP13 NLRP1 SLC11A2 STK11 TNF 0.829 0.9 0.857 0.876 IL1B IL6 MMP13 RGS2 SDK1 SLC40A1 0.78 0.956 0.857 0.869 CASP9 EPO IL10 NFKB1 RGS2 STK11 0.823 0.9 0.857 0.837 CASP9 GH1 HAMP IL10 NFKB2 STK11 0.81 0.915 0.857 0.85 CASP9 HFE IL6 SLC40A1 STK11 TGFB1 0.825 0.9 0.857 0.85 EPO IL10 NFKB2 PAX8 SLC11A2 STK11 0.811 0.915 0.857 0.852 HAMP IL10 MUC1 NFKB1 SMAD3 STK11 0.81 0.913 0.857 0.864 CCL27 KRT83 PAX8 RGS2 SIRT1 TGFB1 0.79 0.944 0.857 0.722 MUC1 NR3C1 SDK1 SLC40A1 STK11 TNF 0.79 0.942 0.857 0.78 ADAMTS4 HFE IL10 NFKB1 STK11 VEGFA 0.848 0.869 0.857 0.86 CASP1 HFE IL10 NFKB1 STK11 VEGFA 0.848 0.869 0.857 0.851 HFE IL10 NFKB1 PAX8 STK11 VEGFA 0.848 0.869 0.857 0.853 EDAR IL10 MMP13 NLRP1 PPARG STK11 0.824 0.902 0.857 0.826 HAMP IL10 IL6 NFKB1 NLRP3 STK11 0.811 0.914 0.857 0.847 HAMP IL10 MUC1 NFKB1 NLRP3 STK11 0.811 0.912 0.857 0.862 CCL27 MUC1 NR3C1 SLC40A1 STK11 TNF 0.791 0.941 0.857 0.786 CASP9 KRT83 NLRP1 SIRT1 SLC11A2 STK11 0.835 0.884 0.857 0.841 CASP9 IL10 NFKB1 NR3C1 PAX8 STK11 0.828 0.9 0.857 0.826 CASP1 HFE IL10 NFKB1 NLRP1 STK11 0.817 0.912 0.857 0.833 GCKR MUC1 NFKB1 NR3C1 RGS2 STK11 0.78 0.955 0.857 0.735 KRT83 MUC1 NFKB1 NR3C1 STK11 VEGFA 0.78 0.955 0.857 0.74 ADAMTS4 FKBP5 HFE IL10 NFKB1 STK11 0.849 0.869 0.857 0.851 CASP1 FKBP5 HFE IL10 NFKB1 STK11 0.849 0.869 0.857 0.854 CD274 FKBP5 HFE IL10 NFKB1 STK11 0.849 0.869 0.857 0.852 FKBP5 GH1 HFE IL10 NFKB1 STK11 0.849 0.869 0.857 0.862 FKBP5 HFE IL10 NFKB1 PAX8 STK11 0.849 0.869 0.857 0.852 FKBP5 HFE IL10 NFKB1 SMAD3 STK11 0.849 0.869 0.857 0.853 EPO IL10 IL6 NFKB1 PAX8 STK11 0.821 0.899 0.857 0.836 FKBP5 IL10 NFKB1 SLC40A1 STK11 VEGFA 0.822 0.9 0.857 0.848 IL10 IL1A IL6 NFKB1 SLC6A3 STK11 0.812 0.914 0.857 0.839 CCL27 IL18 MUC1 NLRP1 SIRT1 STK11 0.814 0.912 0.857 0.839 MUC1 NFKB2 NR3C1 RGS2 SLC40A1 STK11 0.792 0.942 0.857 0.759 CACNA1C MMP13 NLRP1 NLRP3 SLC11A2 STK11 0.853 0.871 0.857 0.855 CACNA1C IL18 MMP13 MUC1 NLRP1 STK11 0.812 0.913 0.857 0.846 ADAMTS4 FKBP5 GCKR IL10 NFKB1 STK11 0.843 0.884 0.857 0.848 FKBP5 HFE2 IL10 NFKB1 SMAD3 STK11 0.83 0.896 0.857 0.858 FGFR2 HAMP IL10 NFKB1 PAX8 STK11 0.841 0.884 0.857 0.833 IL10 KRT83 MMP13 NLRP1 SMAD3 STK11 0.85 0.886 0.857 0.858 NR3C1 SLC11A2 SLC40A1 STK11 TNF VEGFA 0.794 0.941 0.857 0.767 CASP9 MMP13 NLRP1 RGS2 SMAD3 STK11 0.903 0.824 0.857 0.872 CCL27 RGS2 SIRT1 SLC40A1 SMAD3 TGFB1 0.779 0.955 0.857 0.856 CASP9 CCL27 EDAR RGS2 SLC40A1 STK11 0.824 0.898 0.857 0.842 CASP1 FGFR2 HFE IL10 NFKB1 STK11 0.85 0.869 0.857 0.842 CCL27 MUC1 SDK1 SLC22A4 STK11 TGFB1 0.85 0.871 0.857 0.846 CRHR1 IL10 MMP13 NFKB1 SDK1 SIRT1 0.879 0.843 0.857 0.858 ABCA1 IL10 IL1B MUC1 RGS2 STK11 0.8 0.926 0.857 0.783 ADAMTS4 IL10 IL1B MUC1 NFKB1 STK11 0.813 0.914 0.857 0.847 CD274 IL10 IL1B MUC1 NFKB1 STK11 0.813 0.914 0.857 0.844 IL10 IL1B MUC1 NFKB1 NLRP3 STK11 0.813 0.914 0.857 0.852 CASP1 FKBP5 IL10 MUC1 NFKB1 STK11 0.81 0.912 0.857 0.851 CASP1 IL10 MUC1 NFKB1 PAX8 STK11 0.81 0.912 0.857 0.851 IL10 MUC1 NFKB1 PAX8 RGS2 STK11 0.81 0.912 0.857 0.849 CRHR1 FGFR2 HFE MMP13 SDK1 SLC40A1 0.788 0.942 0.857 0.837 EPO IL10 NFKB2 SIRT1 SLC11A2 STK11 0.829 0.903 0.857 0.855 FKBP5 IL10 MMP13 NFKB1 STK11 TGFB1 0.861 0.857 0.857 0.87 HAMP IL10 SMAD3 STK11 TGFB1 TNF 0.828 0.902 0.857 0.819 CASP9 FGFR2 RGS2 SLC40A1 STK11 VEGFA 0.799 0.928 0.857 0.832 ADAMTS4 FKBP5 IL10 MUC1 NFKB2 STK11 0.848 0.871 0.857 0.832 CD274 HAMP HFE IL10 NFKB1 STK11 0.847 0.87 0.857 0.862 HAMP HFE IL10 IL18 NFKB1 STK11 0.847 0.87 0.857 0.851 FKBP5 RGS2 SKA2 SLC40A1 SLC6A3 STK11 0.802 0.926 0.857 0.863 CCL27 FKBP5 IL1B MMP13 RGS2 SLC40A1 0.815 0.912 0.857 0.85 ABCA1 CASP9 NLRP1 RGS2 SLC40A1 STK11 0.804 0.927 0.857 0.846 IL10 MMP13 NFKB1 NLRP3 SDK1 STK11 0.868 0.856 0.857 0.867 CD274 FKBP5 HAMP IL10 NFKB1 STK11 0.839 0.884 0.857 0.851 CASP9 GH1 RGS2 SLC11A2 SLC40A1 STK11 0.787 0.942 0.857 0.827 CCL27 CRHR1 IL1B IL6 RGS2 SLC40A1 0.787 0.942 0.857 0.844 IL1B IL6 RGS2 SKA2 SLC40A1 STK11 0.898 0.826 0.857 0.891 CASP9 HFE MMP13 MUC1 NLRP1 STK11 0.847 0.869 0.857 0.863 HFE IL10 IL6 KRT1 NFKB1 STK11 0.846 0.87 0.857 0.85 CD274 EPO IL10 NFKB1 PAX8 STK11 0.823 0.899 0.857 0.846 CACNA1C CASP9 CCL27 MMP13 PPARG STK11 0.834 0.886 0.857 0.818 IL10 NFKB1 NLRP1 NR3C1 STK11 TNF 0.788 0.942 0.857 0.785 CASP9 CCL27 GH1 IL10 NLRP1 STK11 0.847 0.871 0.857 0.855 CCL27 HAMP HFE IL10 NFKB1 STK11 0.846 0.87 0.857 0.86 IL10 MMP13 MUC1 NFKB1 SIRT1 STK11 0.849 0.87 0.857 0.907 ABCA1 IL10 SDK1 SIRT1 SLC11A2 STK11 0.824 0.9 0.857 0.82 IL10 NFKB1 RGS2 SDK1 SLC40A1 STK11 0.821 0.899 0.857 0.869 IL18 IL1B IL6 RGS2 SLC40A1 STK11 0.898 0.827 0.857 0.87 FKBP5 MUC1 NR3C1 SLC40A1 STK11 TNF 0.788 0.942 0.857 0.765 MUC1 NR3C1 SLC11A2 SLC40A1 STK11 TNF 0.788 0.942 0.857 0.754 HFE MMP13 MUC1 NFKB2 SLC22A4 STK11 0.823 0.899 0.857 0.852 HAMP IL10 MUC1 NFKB1 STK11 TNF 0.809 0.912 0.857 0.869 CASP9 MUC1 NLRP1 NR3C1 SLC40A1 STK11 0.79 0.943 0.857 0.795 RGS2 SDK1 SLC40A1 SLC6A3 SMAD3 STK11 0.787 0.942 0.857 0.854 GCKR IL10 MUC1 NFKB2 STK11 VEGFA 0.808 0.913 0.857 0.821 FGFR2 IL10 MMP13 NFKB1 SLC22A4 STK11 0.862 0.856 0.857 0.847 CASP1 FGFR2 IL10 NFKB1 SLC11A2 STK11 0.811 0.914 0.857 0.835 CCL27 HAMP IL10 IL18 NLRP1 STK11 0.808 0.914 0.857 0.796 CD274 CRHR1 IL10 NFKB1 SLC6A3 STK11 0.81 0.914 0.857 0.865 CRHR1 HAMP IL10 NFKB1 SLC6A3 STK11 0.81 0.914 0.857 0.856 IL10 MUC1 NFKB1 SKA2 STK11 TNF 0.81 0.912 0.857 0.863 EPO HAMP IL10 NFKB2 SLC11A2 STK11 0.809 0.915 0.857 0.849 CASP9 HFE2 IL10 MMP13 NFKB2 STK11 0.897 0.83 0.857 0.87 CASP9 CCL27 IL18 SIRT1 SLC11A2 STK11 0.791 0.944 0.857 0.794 CASP9 CCL27 HFE2 IL10 NLRP1 STK11 0.887 0.843 0.857 0.863 ABCA1 IL10 MUC1 NFKB1 SLC11A2 STK11 0.808 0.912 0.857 0.835 HAMP IGF1 IL10 MUC1 NFKB1 STK11 0.808 0.912 0.857 0.865 CASP9 CCL27 IL10 SIRT1 SLC11A2 STK11 0.818 0.915 0.856 0.794 HFE IL10 NFKB1 NLRP3 SLC6A3 STK11 0.813 0.914 0.856 0.86 GH1 IL10 MUC1 NFKB2 PAX8 STK11 0.813 0.912 0.856 0.842 GCKR IL10 NFKB1 SLC11A2 STK11 TNF 0.827 0.9 0.856 0.825 EPO HFE MUC1 RGS2 SDK1 SLC40A1 0.759 0.986 0.856 0.735 ABCA1 CACNA1C IL10 MUC1 NFKB1 STK11 0.809 0.912 0.856 0.838 CASP1 HAMP IL10 NFKB1 SLC40A1 STK11 0.82 0.899 0.856 0.864 CASP9 CCL27 HAMP IL10 KRT83 STK11 0.811 0.915 0.856 0.838 CCL27 IL10 MUC1 NFKB1 PAX8 STK11 0.809 0.912 0.856 0.856 CCL27 IL10 MUC1 NFKB1 SLC11A2 STK11 0.809 0.912 0.856 0.844 CD274 FKBP5 IL10 MUC1 NFKB1 STK11 0.809 0.912 0.856 0.854 FKBP5 GH1 IL10 MUC1 NFKB1 STK11 0.809 0.912 0.856 0.853 HAMP IL10 NFKB1 NFKB2 PAX8 STK11 0.82 0.899 0.856 0.835 HFE2 IL10 MUC1 NFKB1 PAX8 STK11 0.809 0.912 0.856 0.852 IL10 MUC1 NFKB2 SLC11A2 STK11 VEGFA 0.808 0.913 0.856 0.825 CASP9 HAMP HFE MMP13 SLC40A1 STK11 0.847 0.872 0.856 0.843 CASP9 CCL27 SDK1 SIRT1 SLC11A2 STK11 0.831 0.9 0.856 0.81 IL10 MMP13 NFKB1 SIRT1 SKA2 STK11 0.901 0.828 0.856 0.863 CASP3 CCL27 IL10 NLRP1 RGS2 SLC40A1 0.772 0.971 0.856 0.809 CASP3 CCL27 RGS2 SIRT1 SLC11A2 SLC40A1 0.823 0.899 0.856 0.831 FKBP5 GCKR IL10 NFKB1 PPARG STK11 0.834 0.885 0.856 0.839 CACNA1C CASP9 MMP13 MUC1 NLRP1 STK11 0.82 0.9 0.856 0.884 ABCA1 MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.739 ABCA1 MUC1 NR3C1 PAX8 SLC40A1 STK11 0.791 0.941 0.856 0.754 ADAMTS4 MUC1 NR3C1 PAX8 SLC40A1 STK11 0.791 0.941 0.856 0.759 CACNA1C MUC1 NFKB1 NR3C1 RGS2 STK11 0.791 0.941 0.856 0.732 CACNA1C MUC1 NFKB1 NR3C1 SLC22A4 STK11 0.791 0.941 0.856 0.733 CACNA1C MUC1 NFKB1 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.745 CACNA1C MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.738 CACNA1C MUC1 NFKB2 NR3C1 SLC22A4 STK11 0.791 0.941 0.856 0.737 CASP1 FGFR2 MUC1 NFKB1 NR3C1 STK11 0.791 0.941 0.856 0.729 CASP1 HFE MUC1 NFKB1 NR3C1 STK11 0.791 0.941 0.856 0.741 CASP1 KRT1 MUC1 NFKB1 NR3C1 STK11 0.791 0.941 0.856 0.743 CASP1 MUC1 NFKB1 NR3C1 RGS2 STK11 0.791 0.941 0.856 0.737 CCL27 HFE MUC1 NR3C1 SLC40A1 SLC6A3 0.791 0.941 0.856 0.776 CD274 IL6 MUC1 NFKB2 NR3C1 STK11 0.791 0.941 0.856 0.754 CD274 MUC1 NFKB1 NR3C1 RGS2 STK11 0.791 0.941 0.856 0.737 EDAR HFE MUC1 NFKB2 NR3C1 STK11 0.791 0.941 0.856 0.775 EPO MUC1 NFKB1 NR3C1 RGS2 STK11 0.791 0.941 0.856 0.735 EPO MUC1 NFKB1 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.733 EPO MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.739 EPO MUC1 NR3C1 PAX8 SLC40A1 STK11 0.791 0.941 0.856 0.748 FGFR2 MUC1 NFKB1 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.752 FGFR2 MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.745 FGFR2 MUC1 NR3C1 PAX8 SLC40A1 STK11 0.791 0.941 0.856 0.756 FKBP5 MUC1 NFKB1 NR3C1 RGS2 STK11 0.791 0.941 0.856 0.741 FKBP5 MUC1 NR3C1 PAX8 SLC40A1 STK11 0.791 0.941 0.856 0.77 GCKR MUC1 NFKB1 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.733 GCKR MUC1 NFKB2 NR3C1 SKA2 STK11 0.791 0.941 0.856 0.772 GCKR MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.732 GCKR MUC1 NR3C1 PAX8 SLC40A1 STK11 0.791 0.941 0.856 0.756 GH1 MUC1 NFKB1 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.747 GH1 MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.743 GH1 MUC1 NR3C1 PAX8 SLC40A1 STK11 0.791 0.941 0.856 0.755 HAMP MUC1 NFKB1 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.733 HAMP MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.736 HAMP MUC1 NR3C1 PAX8 SLC40A1 STK11 0.791 0.941 0.856 0.747 HFE MUC1 NFKB2 NR3C1 RGS2 STK11 0.791 0.941 0.856 0.746 HFE MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.78 HFE2 MUC1 NFKB1 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.743 HFE2 MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.75 HFE2 MUC1 NR3C1 PAX8 SLC40A1 STK11 0.791 0.941 0.856 0.762 IL1A MUC1 NFKB1 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.75 IL1A MUC1 NR3C1 PAX8 SLC40A1 STK11 0.791 0.941 0.856 0.757 KRT1 MUC1 NFKB1 NR3C1 RGS2 STK11 0.791 0.941 0.856 0.739 KRT1 MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.75 KRT1 MUC1 NR3C1 PAX8 SLC40A1 STK11 0.791 0.941 0.856 0.755 KRT83 MUC1 NFKB1 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.75 KRT83 MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.737 KRT83 MUC1 NR3C1 PAX8 SLC40A1 STK11 0.791 0.941 0.856 0.759 MMP13 MUC1 NR3C1 PAX8 SLC40A1 STK11 0.791 0.941 0.856 0.775 MUC1 NFKB1 NFKB2 NR3C1 SLC40A1 STK11 0.791 0.941 0.856 0.748 MUC1 NFKB1 NR3C1 PAX8 SLC40A1 STK11 0.791 0.941 0.856 0.765 MUC1 NFKB1 NR3C1 SLC22A4 SLC40A1 STK11 0.791 0.941 0.856 0.75 MUC1 NFKB1 NR3C1 SLC40A1 STK11 VEGFA 0.791 0.941 0.856 0.747 MUC1 NFKB2 NR3C1 PAX8 SKA2 STK11 0.791 0.941 0.856 0.765 MUC1 NFKB2 NR3C1 PAX8 SLC40A1 STK11 0.791 0.941 0.856 0.752 MUC1 NFKB2 NR3C1 SKA2 SLC40A1 STK11 0.791 0.941 0.856 0.758 MUC1 NFKB2 NR3C1 SLC22A4 SLC40A1 STK11 0.791 0.941 0.856 0.743 MUC1 NR3C1 PAX8 SLC22A4 SLC40A1 STK11 0.791 0.941 0.856 0.761 MUC1 NR3C1 PAX8 SLC40A1 STK11 VEGFA 0.791 0.941 0.856 0.759 ABCA1 CD274 FKBP5 IL10 MUC1 STK11 0.777 0.956 0.856 0.791 ABCA1 CD274 GH1 IL10 MUC1 STK11 0.777 0.956 0.856 0.791 ABCA1 CRHR1 IGF1 IL10 MUC1 STK11 0.777 0.956 0.856 0.797 GH1 IL10 MMP13 NFKB1 NLRP1 STK11 0.863 0.856 0.856 0.847 CCL27 IL10 MUC1 NFKB1 SKA2 STK11 0.81 0.912 0.856 0.864 CD274 IL10 MUC1 NFKB1 SKA2 STK11 0.81 0.912 0.856 0.869 IL10 KRT83 MUC1 NFKB1 SKA2 STK11 0.81 0.912 0.856 0.855 IL10 MUC1 NFKB1 NLRP3 SKA2 STK11 0.81 0.912 0.856 0.851 CD274 IL10 MMP13 NFKB1 SLC6A3 STK11 0.819 0.899 0.856 0.875 GCKR IL10 MUC1 NFKB2 STK11 TNF 0.808 0.912 0.856 0.81 IGF1 IL10 MMP13 NFKB1 SLC6A3 STK11 0.819 0.899 0.856 0.872 CASP9 FGFR2 IL6 SLC6A3 STK11 TGFB1 0.815 0.915 0.856 0.83 MMP13 MUC1 NLRP1 SKA2 SLC11A2 STK11 0.823 0.899 0.856 0.866 CACNA1C CASP9 CCL27 IL10 STK11 VEGFA 0.812 0.917 0.856 0.801 CCL27 HAMP IL10 PAX8 STK11 TNF 0.825 0.9 0.856 0.825 ABCA1 CASP1 MMP13 RGS2 SIRT1 SLC40A1 0.825 0.898 0.856 0.835 CCL27 FKBP5 MUC1 NLRP1 SIRT1 STK11 0.811 0.912 0.856 0.815 CD274 IL10 MUC1 NFKB1 SLC6A3 STK11 0.808 0.912 0.856 0.864 FKBP5 IL10 MUC1 NFKB1 SLC6A3 STK11 0.808 0.912 0.856 0.876 IL10 KRT83 MUC1 NFKB1 SLC6A3 STK11 0.808 0.912 0.856 0.85 IL10 MUC1 NFKB1 PAX8 SLC6A3 STK11 0.808 0.912 0.856 0.869 IL6 MMP13 NFKB1 NLRP1 NLRP3 STK11 0.864 0.855 0.856 0.866 ADAMTS4 GCKR IL10 MUC1 NFKB1 STK11 0.81 0.912 0.856 0.851 GCKR IL10 MUC1 NFKB1 SLC22A4 STK11 0.81 0.912 0.856 0.849 CRHR1 EPO IL10 MMP13 NFKB1 STK11 0.857 0.857 0.856 0.863 CRHR1 IL10 MMP13 NFKB1 PPARG STK11 0.857 0.857 0.856 0.861 IL10 NFKB1 NLRP3 SLC11A2 SLC40A1 STK11 0.814 0.914 0.856 0.846 CASP9 CRHR1 RGS2 SLC22A4 SLC40A1 STK11 0.798 0.928 0.856 0.818 CASP9 EDAR EPO RGS2 SLC40A1 STK11 0.8 0.928 0.856 0.83 IL18 MUC1 SDK1 SLC22A4 SLC40A1 STK11 0.8 0.928 0.856 0.818 CCL27 HFE IL6 RGS2 SLC40A1 STK11 0.868 0.856 0.856 0.872 ABCA1 IL10 MMP13 NFKB1 RGS2 STK11 0.859 0.856 0.856 0.868 CCL27 IL1A RGS2 SDK1 SLC40A1 TNF 0.76 0.985 0.856 0.771 CASP9 EPO IL10 NFKB1 NLRP3 STK11 0.824 0.9 0.856 0.856 ADAMTS4 CASP9 MUC1 NLRP1 NR3C1 STK11 0.788 0.942 0.856 0.798 IL10 MUC1 NFKB1 PPARG SLC40A1 STK11 0.788 0.942 0.856 0.815 HAMP IL10 IL6 NLRP1 SLC11A2 STK11 0.811 0.913 0.856 0.858 CASP3 IL10 MUC1 NFKB1 STK11 TGFB1 0.814 0.913 0.856 0.854 IL10 NFKB1 NLRP3 SLC40A1 SLC6A3 STK11 0.813 0.914 0.856 0.837 ADAMTS4 IL6 RGS2 SLC40A1 STK11 TGFB1 0.858 0.857 0.856 0.864 CASP9 HFE2 IL10 NFKB1 SKA2 STK11 0.862 0.857 0.856 0.853 CCL27 EPO FKBP5 IL10 NFKB1 STK11 0.845 0.869 0.856 0.83 IL10 NFKB1 SDK1 SLC6A3 STK11 TGFB1 0.859 0.859 0.856 0.829 IL10 MMP13 NFKB1 RGS2 SIRT1 STK11 0.892 0.827 0.856 0.89 IL10 IL6 MMP13 NFKB1 PAX8 STK11 0.866 0.856 0.856 0.843 CACNA1C CASP9 IL10 IL18 MMP13 STK11 0.852 0.872 0.856 0.825 EPO MUC1 NLRP1 SLC11A2 SLC6A3 STK11 0.787 0.942 0.856 0.838 ABCA1 CRHR1 IL10 MUC1 NFKB1 STK11 0.808 0.913 0.856 0.86 ABCA1 IL10 KRT1 MUC1 NFKB1 STK11 0.808 0.912 0.856 0.824 CCL27 HAMP MUC1 NLRP1 NLRP3 STK11 0.809 0.913 0.856 0.837 FKBP5 HAMP IL1A MUC1 NLRP1 STK11 0.809 0.913 0.856 0.815 HFE IL6 NLRP1 SLC11A2 STK11 TNF 0.848 0.87 0.856 0.851 EPO IL10 MMP13 NFKB1 PAX8 STK11 0.862 0.856 0.856 0.853 ABCA1 CASP9 IL10 MMP13 MUC1 STK11 0.814 0.914 0.856 0.824 ABCA1 FGFR2 IL10 MUC1 NFKB1 STK11 0.808 0.912 0.856 0.84 CASP9 CCL27 HAMP IL10 STK11 VEGFA 0.807 0.915 0.856 0.851 CRHR1 HFE2 IL10 MUC1 NFKB1 STK11 0.809 0.913 0.856 0.869 IGF1 IL10 MUC1 NFKB1 SKA2 STK11 0.808 0.912 0.856 0.856 CACNA1C CASP9 MMP13 NLRP1 RGS2 STK11 0.904 0.826 0.856 0.898 IL10 IL6 MMP13 NLRP1 SLC11A2 STK11 0.847 0.871 0.856 0.856 HFE IL10 KRT1 MMP13 NFKB1 SIRT1 0.879 0.841 0.856 0.868 FKBP5 HFE IL10 IL6 NFKB1 STK11 0.847 0.869 0.856 0.88 CASP9 IL10 NFKB1 PAX8 SMAD3 STK11 0.821 0.9 0.856 0.839 CCL27 HAMP IL10 NFKB1 SLC6A3 STK11 0.819 0.9 0.856 0.858 CASP3 CRHR1 FKBP5 IL10 NFKB1 STK11 0.817 0.899 0.856 0.852 HFE IL10 MUC1 NFKB1 NFKB2 STK11 0.833 0.883 0.856 0.863 FKBP5 IL10 MUC1 NFKB1 NLRP1 STK11 0.807 0.912 0.856 0.854 IL10 MUC1 NFKB1 RGS2 SKA2 STK11 0.807 0.912 0.856 0.862 CASP9 CRHR1 IL10 NFKB1 SKA2 STK11 0.864 0.859 0.856 0.842 GH1 IL10 MMP13 NFKB2 SLC11A2 STK11 0.859 0.857 0.856 0.846 HFE IL10 NFKB1 SLC11A2 STK11 TGFB1 0.864 0.859 0.856 0.847 CCL27 IL10 RGS2 SLC22A4 SLC40A1 STK11 0.833 0.885 0.856 0.863 HAMP IL10 SLC11A2 SLC22A4 SMAD3 STK11 0.809 0.914 0.856 0.839 HFE2 IL10 MMP13 NLRP1 SLC11A2 STK11 0.848 0.871 0.856 0.872 CASP9 CCL27 HAMP IL10 SLC40A1 STK11 0.819 0.9 0.856 0.872 ABCA1 GCKR IL10 MUC1 STK11 TGFB1 0.81 0.914 0.856 0.816 HFE MMP13 SDK1 SIRT1 SLC40A1 TNF 0.81 0.913 0.856 0.861 CCL27 RGS2 SDK1 SLC40A1 STK11 VEGFA 0.823 0.898 0.856 0.86 CASP3 FKBP5 HAMP IL10 NFKB1 STK11 0.837 0.884 0.856 0.849 GH1 HAMP IL10 NFKB1 PAX8 STK11 0.839 0.884 0.856 0.842 CASP9 FKBP5 PPARG RGS2 SLC40A1 STK11 0.798 0.928 0.856 0.834 HFE MMP13 RGS2 SLC40A1 SLC6A3 STK11 0.848 0.871 0.856 0.882 ADAMTS4 IL10 MUC1 NFKB2 SIRT1 STK11 0.789 0.943 0.856 0.799 GH1 IL10 MUC1 NFKB2 SIRT1 STK11 0.789 0.943 0.856 0.808 IL10 MUC1 NFKB2 SIRT1 STK11 VEGFA 0.789 0.943 0.856 0.797 GCKR HAMP IL10 NFKB1 SLC11A2 STK11 0.825 0.9 0.856 0.849 GCKR IL10 IL1A MUC1 NFKB2 STK11 0.822 0.9 0.856 0.827 HFE IL10 RGS2 SLC40A1 SLC6A3 STK11 0.822 0.902 0.856 0.876 ADAMTS4 IL10 MUC1 NFKB1 STK11 TGFB1 0.81 0.913 0.856 0.856 IL10 MUC1 NFKB1 NLRP1 SIRT1 STK11 0.81 0.913 0.856 0.844 FKBP5 IL10 NFKB1 NLRP1 SMAD3 STK11 0.82 0.898 0.856 0.848 ADAMTS4 CASP9 IL10 IL6 NFKB1 STK11 0.822 0.9 0.856 0.849 ABCA1 CCL27 IL10 IL18 NLRP1 SIRT1 0.792 0.942 0.856 0.81 CCL27 FKBP5 IL10 NFKB1 STK11 VEGFA 0.862 0.855 0.856 0.842 CASP9 GH1 IL10 IL6 NFKB1 STK11 0.821 0.9 0.856 0.847 CASP9 IL10 IL6 NFKB1 SLC11A2 STK11 0.821 0.9 0.856 0.854 HAMP IGF1 IL10 NFKB1 SLC6A3 STK11 0.82 0.899 0.856 0.857 CASP9 IL6 RGS2 SLC22A4 SLC40A1 STK11 0.839 0.884 0.856 0.855 FKBP5 HFE NFKB2 SLC11A2 STK11 VEGFA 0.786 0.942 0.856 0.811 HFE NFKB2 PAX8 SLC11A2 STK11 VEGFA 0.786 0.942 0.856 0.795 CASP9 EPO MMP13 NLRP1 RGS2 STK11 0.906 0.824 0.856 0.885 CASP9 MMP13 NFKB2 NLRP1 RGS2 STK11 0.906 0.824 0.856 0.876 ABCA1 CASP1 MUC1 NLRP1 STK11 TGFB1 0.833 0.885 0.856 0.823 CCL27 NFKB1 RGS2 SIRT1 SLC40A1 TGFB1 0.788 0.941 0.856 0.836 CASP9 HFE2 IL10 NLRP1 RGS2 STK11 0.889 0.856 0.856 0.877 ABCA1 IL10 NFKB1 NLRP3 SMAD3 STK11 0.812 0.912 0.856 0.808 IL10 MMP13 NLRP1 SLC22A4 SMAD3 STK11 0.855 0.871 0.856 0.867 ABCA1 CD274 IL10 IL1B MUC1 STK11 0.776 0.956 0.856 0.766 CASP9 CCL27 IL10 SMAD3 STK11 VEGFA 0.811 0.915 0.856 0.802 IL10 MUC1 NFKB2 SIRT1 SMAD3 STK11 0.787 0.943 0.856 0.824 CASP9 CRHR1 HAMP IL10 NFKB1 STK11 0.821 0.9 0.856 0.875 HFE IL18 IL1B RGS2 SKA2 SLC40A1 0.769 0.97 0.856 0.803 HAMP IL10 IL1B MUC1 NFKB1 STK11 0.823 0.9 0.856 0.842 CASP9 HFE IL10 NFKB1 NLRP3 STK11 0.834 0.886 0.856 0.853 CASP9 HFE NLRP1 SLC11A2 STK11 VEGFA 0.809 0.914 0.856 0.85 CCL27 RGS2 SIRT1 SLC40A1 TGFB1 VEGFA 0.788 0.941 0.856 0.846 IL10 MMP13 NFKB1 NLRP1 SLC22A4 STK11 0.842 0.885 0.856 0.856 CACNA1C HAMP IL10 NLRP1 PAX8 STK11 0.784 0.943 0.856 0.789 ABCA1 IL10 IL1B MUC1 PAX8 STK11 0.776 0.956 0.856 0.771 HFE MMP13 MUC1 NFKB2 SLC40A1 STK11 0.821 0.899 0.856 0.854 IL18 MMP13 MUC1 NLRP1 SDK1 STK11 0.851 0.87 0.856 0.876 HAMP HFE MMP13 NLRP1 SLC11A2 STK11 0.86 0.855 0.856 0.851 HFE MMP13 NFKB2 NLRP1 SLC11A2 STK11 0.86 0.855 0.856 0.848 CASP9 MMP13 MUC1 NFKB2 SKA2 STK11 0.829 0.885 0.856 0.828 IL10 NFKB1 NLRP3 SKA2 STK11 TGFB1 0.876 0.859 0.856 0.852 CCL27 HAMP MMP13 RGS2 SDK1 SLC40A1 0.782 0.957 0.856 0.796 ADAMTS4 CASP9 CCL27 FGFR2 IL10 STK11 0.813 0.915 0.856 0.808 MMP13 NLRP1 RGS2 SDK1 SIRT1 STK11 0.866 0.855 0.856 0.868 MMP13 NFKB1 NLRP1 SDK1 SLC11A2 STK11 0.892 0.826 0.856 0.853 IL10 MMP13 NFKB1 PAX8 STK11 TGFB1 0.896 0.83 0.856 0.863 IL10 MUC1 NFKB1 SLC22A4 SLC40A1 STK11 0.787 0.941 0.856 0.833 IL10 MMP13 MUC1 NLRP1 SLC22A4 STK11 0.839 0.885 0.856 0.862 CASP1 CASP3 CASP9 IL10 NR3C1 STK11 0.788 0.943 0.856 0.829 IL10 MMP13 NFKB1 SLC22A4 STK11 TGFB1 0.856 0.857 0.856 0.865 CACNA1C IL18 MUC1 NFKB2 SLC40A1 STK11 0.797 0.928 0.856 0.778 HAMP MUC1 NR3C1 SLC40A1 STK11 TNF 0.797 0.928 0.856 0.763 IL18 KRT1 MUC1 NFKB1 SLC40A1 STK11 0.797 0.928 0.856 0.775 IL18 KRT1 MUC1 NFKB2 SLC40A1 STK11 0.797 0.928 0.856 0.776 IL18 KRT83 MUC1 NFKB1 SLC40A1 STK11 0.797 0.928 0.856 0.777 IL18 MUC1 NFKB1 NFKB2 SLC40A1 STK11 0.797 0.928 0.856 0.772 IL18 MUC1 NFKB2 PAX8 SLC40A1 STK11 0.797 0.928 0.856 0.776 IL18 MUC1 NFKB2 SLC11A2 SLC40A1 STK11 0.797 0.928 0.856 0.774 CCL27 IL10 NFKB1 NLRP1 NR3C1 STK11 0.803 0.928 0.856 0.786 HFE RGS2 SKA2 SLC40A1 SLC6A3 STK11 0.81 0.913 0.856 0.875 HAMP HFE IL10 NFKB1 NR3C1 STK11 0.822 0.899 0.856 0.826 CD274 IL10 IL6 NFKB1 PPARG STK11 0.789 0.943 0.856 0.831 CASP9 CCL27 HAMP IL10 SDK1 STK11 0.81 0.917 0.856 0.849 FGFR2 IL6 MUC1 SDK1 STK11 TGFB1 0.8 0.929 0.856 0.762 HFE IL6 MUC1 SDK1 STK11 TGFB1 0.8 0.929 0.856 0.78 CASP3 CASP9 CCL27 KRT1 RGS2 SLC40A1 0.768 0.97 0.856 0.776 CASP9 CCL27 IL10 NLRP1 PAX8 STK11 0.848 0.871 0.856 0.862 CACNA1C HFE MMP13 NLRP1 SLC11A2 STK11 0.865 0.856 0.856 0.883 CASP9 FGFR2 MUC1 NR3C1 SLC40A1 STK11 0.8 0.928 0.856 0.779 CASP9 KRT83 MUC1 NR3C1 SLC40A1 STK11 0.8 0.928 0.856 0.783 CASP9 MUC1 NFKB1 NR3C1 SLC40A1 STK11 0.8 0.928 0.856 0.78 CASP9 MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.8 0.928 0.856 0.79 CASP9 MUC1 NR3C1 PAX8 SLC40A1 STK11 0.8 0.928 0.856 0.773 CASP9 MUC1 NR3C1 PPARG SLC40A1 STK11 0.8 0.928 0.856 0.747 CASP9 MUC1 NR3C1 RGS2 SLC40A1 STK11 0.8 0.928 0.856 0.785 FGFR2 IL6 RGS2 SLC40A1 STK11 TGFB1 0.857 0.857 0.856 0.867 ADAMTS4 CASP9 IL10 NFKB1 RGS2 STK11 0.819 0.9 0.856 0.832 ADAMTS4 EPO IL10 NFKB1 SLC11A2 STK11 0.82 0.899 0.856 0.828 IL10 NFKB1 NFKB2 SLC11A2 STK11 VEGFA 0.82 0.899 0.856 0.856 ABCA1 CASP1 HAMP MUC1 NLRP1 STK11 0.813 0.912 0.856 0.793 HFE NFKB2 NLRP3 SLC11A2 STK11 VEGFA 0.785 0.942 0.856 0.803 CASP9 IL10 IL6 NFKB1 NFKB2 STK11 0.818 0.9 0.856 0.851 HAMP HFE NLRP1 SIRT1 SLC11A2 STK11 0.821 0.899 0.856 0.816 ADAMTS4 FGFR2 IL10 MMP13 NFKB1 STK11 0.864 0.855 0.856 0.854 CD274 FGFR2 IL10 MMP13 NFKB1 STK11 0.864 0.855 0.856 0.849 HFE IL10 MUC1 NLRP1 STK11 TGFB1 0.839 0.885 0.856 0.85 GH1 HFE IL6 MMP13 NFKB1 STK11 0.852 0.866 0.856 0.87 ADAMTS4 CASP9 HFE IL10 NFKB1 STK11 0.858 0.856 0.856 0.837 CASP9 GH1 IL10 NFKB1 SIRT1 STK11 0.859 0.857 0.856 0.876 CASP9 HFE IL10 NFKB1 RGS2 STK11 0.858 0.856 0.856 0.858 GH1 IL10 NFKB1 SDK1 SLC6A3 STK11 0.858 0.856 0.856 0.845 MMP13 PPARG RGS2 SLC40A1 STK11 TGFB1 0.86 0.856 0.856 0.868 IL10 IL1A NFKB1 RGS2 SIRT1 SLC40A1 0.824 0.9 0.855 0.81 ABCA1 IL10 MUC1 SDK1 STK11 TGFB1 0.82 0.9 0.855 0.823 CACNA1C IL10 NFKB1 NLRP3 SLC11A2 STK11 0.821 0.9 0.855 0.814 CRHR1 FKBP5 IGF1 IL10 NFKB1 STK11 0.817 0.899 0.855 0.833 CRHR1 FKBP5 IL10 KRT83 NFKB1 STK11 0.817 0.899 0.855 0.839 EPO IL10 MMP13 NFKB1 SLC6A3 STK11 0.817 0.899 0.855 0.865 GCKR IL10 NFKB1 SLC11A2 STK11 VEGFA 0.819 0.899 0.855 0.849 IL18 MUC1 SDK1 SLC40A1 STK11 TNF 0.797 0.928 0.855 0.831 CRHR1 IL10 MMP13 NFKB2 SIRT1 TNF 0.813 0.917 0.855 0.847 HAMP IL6 MUC1 NLRP1 NLRP3 STK11 0.838 0.885 0.855 0.826 CASP9 NLRP1 PAX8 RGS2 SLC11A2 STK11 0.826 0.896 0.855 0.821 CCL27 EPO MUC1 NLRP1 STK11 TGFB1 0.821 0.899 0.855 0.818 CCL27 HFE2 MUC1 NLRP1 STK11 TGFB1 0.821 0.899 0.855 0.812 CCL27 MUC1 NLRP1 PAX8 STK11 TGFB1 0.821 0.899 0.855 0.811 ADAMTS4 HFE2 IL10 MUC1 NFKB1 STK11 0.807 0.91 0.855 0.843 FGFR2 HFE2 IL10 MUC1 NFKB1 STK11 0.807 0.91 0.855 0.838 FKBP5 MMP13 NLRP1 RGS2 SDK1 STK11 0.91 0.824 0.855 0.863 CASP9 CD274 EPO IL10 MMP13 STK11 0.857 0.874 0.855 0.855 ABCA1 IL10 MUC1 NLRP1 RGS2 STK11 0.798 0.926 0.855 0.846 HFE MMP13 MUC1 NLRP1 STK11 TGFB1 0.847 0.87 0.855 0.86 CASP3 IL10 MMP13 NFKB1 SDK1 STK11 0.872 0.842 0.855 0.858 CCL27 IL10 KRT1 MMP13 NFKB1 SIRT1 0.89 0.827 0.855 0.859 FKBP5 IL10 NFKB1 SDK1 STK11 TGFB1 0.861 0.857 0.855 0.84 HFE IL10 MMP13 NFKB1 SLC6A3 STK11 0.89 0.827 0.855 0.902 CASP9 GH1 HFE IL10 NFKB1 STK11 0.859 0.856 0.855 0.849 CCL27 EPO IL6 MUC1 NLRP1 STK11 0.809 0.912 0.855 0.807 CASP9 GH1 HAMP IL10 NFKB1 STK11 0.819 0.9 0.855 0.869 CASP9 HAMP IL10 IL6 NFKB2 STK11 0.817 0.9 0.855 0.846 CASP9 HAMP IL10 NFKB1 NLRP3 STK11 0.819 0.9 0.855 0.86 CCL27 HFE IL10 KRT1 NFKB1 STK11 0.843 0.87 0.855 0.836 EDAR HFE IL10 NFKB1 SLC6A3 STK11 0.82 0.899 0.855 0.849 CASP3 CASP9 HFE2 IL10 NFKB1 STK11 0.821 0.899 0.855 0.859 CASP9 HFE2 IL10 NFKB1 STK11 TNF 0.821 0.899 0.855 0.828 CASP9 IL10 NFKB1 PPARG SKA2 STK11 0.82 0.899 0.855 0.849 HFE2 IL10 NFKB1 NLRP3 SLC11A2 STK11 0.821 0.899 0.855 0.833 IL10 NFKB1 NFKB2 PAX8 SLC11A2 STK11 0.822 0.9 0.855 0.836 FKBP5 IL18 NLRP1 RGS2 SDK1 SLC40A1 0.751 1 0.855 0.695 CASP9 CCL27 HAMP HFE IL10 STK11 0.807 0.917 0.855 0.842 IL10 MUC1 NFKB1 SLC40A1 SLC6A3 STK11 0.785 0.943 0.855 0.847 HFE IL1B IL6 RGS2 SLC40A1 TNF 0.767 0.971 0.855 0.832 CASP9 IGF1 IL10 MMP13 NLRP1 STK11 0.851 0.871 0.855 0.848 EPO FKBP5 HAMP IL10 NFKB1 STK11 0.831 0.884 0.855 0.846 IL10 NFKB1 NLRP1 NLRP3 SKA2 STK11 0.854 0.87 0.855 0.86 CRHR1 IL10 KRT83 NFKB1 SMAD3 STK11 0.819 0.899 0.855 0.832 CASP9 CCL27 MMP13 RGS2 SLC40A1 STK11 0.834 0.883 0.855 0.865 CASP9 MUC1 NLRP1 SLC11A2 SLC6A3 STK11 0.784 0.943 0.855 0.838 MUC1 NLRP1 SLC11A2 SLC6A3 STK11 TNF 0.785 0.942 0.855 0.804 EPO HFE IL1B IL6 RGS2 SLC40A1 0.767 0.971 0.855 0.823 HAMP HFE IL1B IL6 RGS2 SLC40A1 0.766 0.971 0.855 0.83 ABCA1 IL10 MMP13 NLRP1 SMAD3 STK11 0.825 0.899 0.855 0.859 CASP9 IL10 IL1A NFKB1 STK11 TGFB1 0.865 0.857 0.855 0.855 CASP9 CCL27 HFE IL6 SLC6A3 STK11 0.818 0.902 0.855 0.844 EPO IL1B MUC1 NFKB2 NR3C1 STK11 0.788 0.941 0.855 0.745 CASP9 GH1 HFE MMP13 SLC40A1 STK11 0.843 0.871 0.855 0.841 EPO IL10 IL18 MUC1 NLRP1 STK11 0.784 0.942 0.855 0.825 FKBP5 IL1A MUC1 NLRP1 SLC6A3 STK11 0.784 0.942 0.855 0.826 HFE IL10 MMP13 NFKB2 SIRT1 SLC6A3 0.784 0.943 0.855 0.862 CASP3 IL10 MUC1 NFKB2 SLC11A2 STK11 0.801 0.929 0.855 0.822 CRHR1 IL1B IL6 RGS2 SLC40A1 TNF 0.795 0.928 0.855 0.798 IL10 MMP13 NFKB1 NFKB2 PPARG STK11 0.876 0.843 0.855 0.835 HAMP IGF1 IL10 MMP13 NFKB1 STK11 0.829 0.885 0.855 0.838 CASP9 HFE KRT83 MMP13 SLC40A1 STK11 0.844 0.871 0.855 0.845 CASP9 HFE MMP13 NFKB2 SLC40A1 STK11 0.844 0.871 0.855 0.846 IL10 SDK1 SKA2 SLC11A2 SLC22A4 STK11 0.825 0.902 0.855 0.816 HAMP HFE IL1B RGS2 SKA2 SLC40A1 0.767 0.97 0.855 0.788 ABCA1 IL10 NLRP1 SKA2 SLC11A2 STK11 0.808 0.913 0.855 0.825 ABCA1 CD274 IL10 MUC1 NFKB2 STK11 0.786 0.941 0.855 0.81 CASP9 GH1 MMP13 NFKB2 PAX8 STK11 0.845 0.872 0.855 0.802 CRHR1 MMP13 NLRP1 SLC11A2 STK11 TGFB1 0.863 0.856 0.855 0.854 HFE IL6 NFKB1 NLRP3 SLC22A4 STK11 0.821 0.898 0.855 0.849 GH1 IL10 MUC1 NFKB1 SLC22A4 STK11 0.807 0.91 0.855 0.821 EPO FKBP5 HFE2 IL10 NFKB1 STK11 0.824 0.896 0.855 0.852 CACNA1C FKBP5 IL10 NFKB1 NFKB2 STK11 0.83 0.885 0.855 0.858 ABCA1 IL10 MUC1 NFKB2 PAX8 STK11 0.785 0.942 0.855 0.81 CD274 IL10 MUC1 NFKB1 SLC40A1 STK11 0.786 0.941 0.855 0.854 IL10 KRT83 MUC1 NFKB1 SLC40A1 STK11 0.786 0.941 0.855 0.838 IL1B IL6 NLRP1 RGS2 SDK1 SLC40A1 0.766 0.971 0.855 0.794 HAMP HFE IL10 NR3C1 STK11 TNF 0.796 0.928 0.855 0.81 CCL27 IL10 NLRP1 PPARG SLC11A2 STK11 0.821 0.899 0.855 0.832 CASP1 IL10 NFKB1 RGS2 SIRT1 SLC40A1 0.818 0.914 0.855 0.82 CCL27 FGFR2 RGS2 SDK1 SLC40A1 TNF 0.751 1 0.855 0.757 CCL27 FKBP5 RGS2 SDK1 SLC40A1 TNF 0.751 1 0.855 0.755 CCL27 HFE2 RGS2 SDK1 SLC40A1 TNF 0.751 1 0.855 0.752 CCL27 IL10 MUC1 NLRP1 STK11 TGFB1 0.847 0.871 0.855 0.856 CASP9 CCL27 IL18 MUC1 SLC40A1 STK11 0.797 0.927 0.855 0.824 HFE MUC1 NR3C1 SLC40A1 STK11 TNF 0.798 0.928 0.855 0.799 IL10 MMP13 NFKB1 NFKB2 SDK1 STK11 0.876 0.842 0.855 0.858 ADAMTS4 IL10 NFKB2 SLC11A2 STK11 VEGFA 0.823 0.902 0.855 0.85 HAMP MMP13 MUC1 NLRP1 SKA2 STK11 0.818 0.899 0.855 0.848 CASP3 CCL27 RGS2 SIRT1 SLC40A1 TNF 0.785 0.941 0.855 0.829 CACNA1C RGS2 SDK1 SLC40A1 SMAD3 STK11 0.822 0.898 0.855 0.84 MMP13 NLRP1 RGS2 SIRT1 SLC11A2 STK11 0.89 0.824 0.855 0.886 CCL27 CD274 MMP13 RGS2 SDK1 SLC40A1 0.782 0.956 0.855 0.823 CACNA1C HAMP IL10 MMP13 NFKB1 STK11 0.847 0.871 0.855 0.856 CASP9 EPO IL10 NFKB1 NR3C1 STK11 0.797 0.928 0.855 0.842 CCL27 CRHR1 MUC1 NLRP1 SDK1 STK11 0.866 0.855 0.855 0.854 CASP3 CASP9 HFE NR3C1 SLC22A4 STK11 0.798 0.927 0.855 0.79 IL1A KRT1 MUC1 NLRP1 NR3C1 STK11 0.788 0.941 0.855 0.779 IL1B IL6 NR3C1 RGS2 SLC40A1 TGFB1 0.796 0.927 0.855 0.785 EPO HFE RGS2 SDK1 SLC40A1 VEGFA 0.751 1 0.855 0.764 HFE IL6 RGS2 SDK1 SLC40A1 TGFB1 0.751 1 0.855 0.779 CASP1 IL1A MUC1 NR3C1 STK11 TNF 0.797 0.927 0.855 0.75 FGFR2 MUC1 NR3C1 SLC40A1 STK11 TNF 0.797 0.927 0.855 0.77 MUC1 NFKB2 NR3C1 SLC40A1 STK11 TNF 0.797 0.927 0.855 0.763 MUC1 NR3C1 SLC22A4 SLC40A1 STK11 TNF 0.797 0.927 0.855 0.772 CASP9 HFE MMP13 SLC11A2 SLC40A1 STK11 0.816 0.9 0.855 0.872 CASP9 IL10 MMP13 NLRP1 SKA2 STK11 0.872 0.857 0.855 0.874 FGFR2 IL1B NR3C1 SIRT1 SLC40A1 TNF 0.765 0.971 0.855 0.693 ABCA1 IL10 NFKB1 NLRP3 PAX8 STK11 0.784 0.942 0.855 0.84 CCL27 EPO RGS2 SDK1 SLC40A1 STK11 0.819 0.898 0.855 0.853 CRHR1 IL10 IL1A NFKB1 SLC6A3 STK11 0.828 0.902 0.855 0.846 EPO HFE MUC1 NLRP1 SDK1 STK11 0.845 0.867 0.855 0.851 IL10 IL1B MUC1 NFKB1 STK11 TGFB1 0.825 0.9 0.855 0.84 CRHR1 HFE2 IL10 NFKB1 SDK1 STK11 0.832 0.885 0.855 0.829 CASP3 CASP9 HAMP IL10 NFKB2 STK11 0.816 0.9 0.855 0.843 CACNA1C CASP9 CCL27 SIRT1 SLC11A2 STK11 0.806 0.931 0.855 0.81 CACNA1C IL10 MUC1 NFKB1 SKA2 STK11 0.817 0.898 0.855 0.865 CRHR1 FGFR2 IL10 MUC1 NFKB1 STK11 0.817 0.898 0.855 0.849 CRHR1 IL10 MUC1 NFKB1 RGS2 STK11 0.816 0.899 0.855 0.853 FKBP5 IL10 NFKB2 SLC11A2 STK11 VEGFA 0.819 0.902 0.855 0.845 IL10 MUC1 NFKB2 PAX8 RGS2 STK11 0.816 0.899 0.855 0.83 CACNA1C CASP9 CCL27 HAMP IL10 STK11 0.818 0.902 0.855 0.839 FKBP5 IL10 NFKB1 SDK1 SLC6A3 STK11 0.819 0.9 0.855 0.847 CACNA1C HAMP HFE IL10 NFKB1 STK11 0.856 0.855 0.855 0.865 CASP9 HFE MMP13 SLC40A1 STK11 TGFB1 0.857 0.856 0.855 0.839 EPO IL6 RGS2 SLC40A1 STK11 TGFB1 0.858 0.857 0.855 0.858 FKBP5 HFE IL10 NFKB1 RGS2 STK11 0.857 0.856 0.855 0.86 HFE MMP13 MUC1 NFKB2 NR3C1 STK11 0.823 0.896 0.855 0.85 EPO HAMP IL10 NFKB1 SLC11A2 STK11 0.82 0.9 0.855 0.855 GH1 HAMP IL10 NFKB1 SLC11A2 STK11 0.818 0.9 0.855 0.839 EPO FKBP5 IGF1 IL10 NFKB1 STK11 0.833 0.884 0.855 0.835 EDAR HAMP IL10 SMAD3 STK11 TGFB1 0.841 0.888 0.855 0.808 EPO HAMP IL10 SMAD3 STK11 TGFB1 0.841 0.888 0.855 0.817 FKBP5 HAMP HFE IL10 STK11 TGFB1 0.841 0.888 0.855 0.814 GH1 HAMP HFE IL10 STK11 TGFB1 0.841 0.888 0.855 0.823 CASP9 GCKR HAMP IL10 SMAD3 STK11 0.823 0.902 0.855 0.85 IL10 MUC1 NLRP1 PAX8 SLC11A2 STK11 0.808 0.912 0.855 0.835 HAMP HFE HFE2 IL10 NFKB1 STK11 0.82 0.898 0.855 0.841 IL10 IL6 MUC1 NFKB1 PAX8 STK11 0.816 0.898 0.855 0.853 EPO HAMP MUC1 NR3C1 PAX8 SLC40A1 0.798 0.927 0.855 0.64 EPO IL18 MUC1 NR3C1 PAX8 SLC40A1 0.798 0.927 0.855 0.638 ADAMTS4 HFE IL10 KRT83 NFKB1 STK11 0.857 0.855 0.855 0.828 ADAMTS4 HFE IL10 NFKB1 STK11 TGFB1 0.857 0.857 0.855 0.84 CASP3 MMP13 RGS2 SLC40A1 STK11 TGFB1 0.86 0.857 0.855 0.873 CASP1 CRHR1 IL10 NFKB1 STK11 VEGFA 0.829 0.886 0.855 0.834 GCKR IL10 NFKB1 SLC11A2 STK11 TGFB1 0.833 0.886 0.855 0.855 CCL27 MMP13 NLRP1 RGS2 SIRT1 SLC40A1 0.851 0.867 0.855 0.857 IGF1 IL10 RGS2 SKA2 SLC40A1 STK11 0.785 0.941 0.855 0.863 CASP9 CRHR1 EPO IL10 NFKB1 STK11 0.818 0.9 0.855 0.874 CASP9 CRHR1 IL10 NFKB1 NLRP3 STK11 0.818 0.9 0.855 0.87 CASP9 CRHR1 IL10 NFKB1 NR3C1 STK11 0.818 0.899 0.855 0.835 HAMP IL10 NFKB1 NR3C1 SLC11A2 STK11 0.82 0.899 0.855 0.82 CASP3 IL10 NFKB1 RGS2 SIRT1 SLC40A1 0.787 0.942 0.855 0.787 ABCA1 CASP1 HFE IL6 MUC1 STK11 0.784 0.942 0.855 0.768 CASP9 FGFR2 IL10 MMP13 NLRP1 STK11 0.866 0.857 0.855 0.876 CASP3 FKBP5 IL10 MUC1 NFKB1 STK11 0.784 0.942 0.855 0.844 IL10 MUC1 NFKB2 NR3C1 PAX8 STK11 0.788 0.941 0.855 0.814 CASP1 FKBP5 GCKR IL10 NFKB1 STK11 0.822 0.899 0.855 0.851 IL10 MUC1 NFKB1 SLC40A1 STK11 TGFB1 0.786 0.943 0.855 0.843 EPO HFE MMP13 SLC40A1 STK11 TGFB1 0.858 0.855 0.855 0.834 IL10 NFKB1 NLRP1 NLRP3 PAX8 STK11 0.819 0.899 0.855 0.862 CASP1 EPO IL10 MUC1 NFKB1 STK11 0.784 0.941 0.855 0.839 CASP3 IL10 MUC1 NFKB1 SLC40A1 STK11 0.786 0.942 0.855 0.858 HFE IL10 MMP13 SLC22A4 SLC6A3 STK11 0.823 0.914 0.855 0.861 IL1B MMP13 RGS2 SDK1 SLC40A1 TNF 0.784 0.941 0.855 0.86 GCKR IL10 MMP13 NFKB1 NFKB2 STK11 0.876 0.843 0.855 0.84 IL10 IL6 MMP13 NFKB1 NFKB2 STK11 0.876 0.843 0.855 0.845 CD274 EPO IL10 NFKB1 NLRP1 STK11 0.795 0.928 0.855 0.829 CD274 GH1 IL10 NFKB1 NLRP3 STK11 0.797 0.928 0.855 0.825 CASP9 HFE MMP13 SKA2 SLC40A1 STK11 0.855 0.857 0.855 0.839 HAMP IL10 NLRP1 SDK1 SLC11A2 STK11 0.819 0.9 0.855 0.843 ABCA1 CASP9 RGS2 SLC11A2 SLC40A1 STK11 0.794 0.928 0.855 0.827 CASP9 HAMP RGS2 SLC22A4 SLC40A1 STK11 0.794 0.928 0.855 0.805 CASP9 NLRP3 RGS2 SDK1 SLC40A1 STK11 0.796 0.929 0.855 0.838 EPO NLRP1 NLRP3 SDK1 SLC11A2 STK11 0.862 0.856 0.855 0.826 CASP3 CASP9 IL10 NFKB1 NLRP3 STK11 0.82 0.9 0.855 0.858 ADAMTS4 CASP9 CCL27 IL10 STK11 VEGFA 0.814 0.917 0.855 0.82 CASP9 IL10 NFKB1 NR3C1 SLC40A1 STK11 0.796 0.927 0.855 0.838 GCKR IL10 KRT1 MUC1 NFKB1 STK11 0.818 0.898 0.855 0.851 EPO IL10 NFKB1 NFKB2 SLC11A2 STK11 0.835 0.886 0.855 0.828 FGFR2 GCKR IL10 NFKB1 SLC11A2 STK11 0.834 0.885 0.855 0.861 IL10 MUC1 NFKB2 PAX8 SLC11A2 STK11 0.816 0.898 0.855 0.834 FKBP5 IL10 NFKB1 SIRT1 STK11 VEGFA 0.859 0.857 0.855 0.843 CASP9 MMP13 SDK1 SLC40A1 STK11 TGFB1 0.864 0.859 0.855 0.824 FKBP5 HFE2 IL10 MUC1 NFKB1 STK11 0.806 0.91 0.855 0.863 CASP9 EDAR NLRP1 RGS2 SLC40A1 STK11 0.816 0.912 0.855 0.848 CACNA1C HAMP IL10 IL1A NFKB1 STK11 0.796 0.928 0.855 0.827 GH1 HAMP IL10 IL1A NFKB1 STK11 0.794 0.928 0.855 0.839 CASP9 IL6 MUC1 RGS2 SLC40A1 STK11 0.81 0.913 0.855 0.848 CRHR1 IL1B IL6 MMP13 RGS2 SLC40A1 0.797 0.927 0.855 0.862 MMP13 MUC1 NLRP1 SLC11A2 STK11 VEGFA 0.831 0.884 0.855 0.862 ADAMTS4 EPO IL10 NFKB2 SLC11A2 STK11 0.823 0.902 0.855 0.843 CCL27 EPO RGS2 SLC6A3 STK11 TGFB1 0.82 0.899 0.855 0.782 CASP9 EPO IL18 RGS2 SLC40A1 STK11 0.806 0.914 0.855 0.811 CASP9 HFE2 RGS2 SLC11A2 SLC40A1 STK11 0.806 0.914 0.855 0.835 IL1B IL6 RGS2 SDK1 SKA2 SLC40A1 0.784 0.941 0.855 0.826 IL1B MMP13 NFKB2 RGS2 SDK1 SLC40A1 0.785 0.942 0.855 0.87 CRHR1 IL10 KRT83 MUC1 NFKB1 STK11 0.818 0.898 0.855 0.832 IL10 IL6 NLRP1 SKA2 SLC11A2 STK11 0.819 0.9 0.855 0.838 CRHR1 IGF1 IL10 NFKB1 SLC6A3 STK11 0.825 0.9 0.855 0.852 ABCA1 CCL27 IL10 MUC1 NLRP1 STK11 0.808 0.913 0.855 0.834 CCL27 MUC1 NLRP1 RGS2 SMAD3 STK11 0.836 0.883 0.855 0.837 ADAMTS4 HFE IL6 MMP13 NFKB1 STK11 0.906 0.811 0.855 0.866 CACNA1C CASP1 CASP9 HFE MMP13 STK11 0.847 0.871 0.855 0.807 CASP9 CCL27 MMP13 PAX8 STK11 VEGFA 0.848 0.874 0.855 0.835 CASP9 CD274 HFE IL6 STK11 TGFB1 0.846 0.871 0.855 0.827 IL10 NFKB1 NFKB2 NLRP1 PAX8 STK11 0.809 0.913 0.855 0.843 CASP3 CASP9 GCKR IL10 NR3C1 STK11 0.798 0.929 0.855 0.828 CCL27 IL10 MUC1 NFKB2 NLRP1 SIRT1 0.818 0.899 0.855 0.833 IL18 MUC1 NFKB2 SKA2 SLC40A1 STK11 0.796 0.927 0.855 0.795 CASP3 IL10 KRT1 NFKB1 PAX8 STK11 0.808 0.913 0.855 0.826 GCKR IL10 KRT1 NFKB1 PAX8 STK11 0.808 0.913 0.855 0.835 GH1 IL10 KRT1 NFKB1 PAX8 STK11 0.808 0.913 0.855 0.828 CASP9 CD274 RGS2 SLC40A1 SLC6A3 STK11 0.809 0.914 0.855 0.839 IL10 NFKB1 PAX8 RGS2 SLC6A3 STK11 0.792 0.928 0.855 0.842 IL10 MUC1 NFKB1 SDK1 SLC6A3 STK11 0.806 0.91 0.855 0.872 EPO IL10 MMP13 NLRP1 SMAD3 STK11 0.855 0.87 0.855 0.86 CASP3 MUC1 NR3C1 SLC40A1 STK11 TNF 0.796 0.927 0.855 0.771 IL10 IL1A NFKB1 NLRP1 NLRP3 STK11 0.847 0.871 0.855 0.861 FKBP5 IL10 IL1B MUC1 NLRP1 STK11 0.81 0.912 0.854 0.823 FKBP5 IL6 SLC11A2 SLC40A1 SLC6A3 STK11 0.796 0.929 0.854 0.84 ABCA1 CASP9 MMP13 RGS2 SLC11A2 STK11 0.819 0.899 0.854 0.833 IL6 MMP13 NLRP1 SDK1 SMAD3 STK11 0.913 0.811 0.854 0.832 MMP13 NLRP1 SLC11A2 SLC22A4 STK11 TGFB1 0.907 0.813 0.854 0.875 CASP1 HAMP IL10 PAX8 STK11 TNF 0.81 0.914 0.854 0.815 CASP3 CASP9 NR3C1 PAX8 SLC40A1 STK11 0.801 0.927 0.854 0.764 CASP9 IL18 NR3C1 SLC40A1 SMAD3 STK11 0.801 0.927 0.854 0.758 CACNA1C HFE2 IL10 NFKB1 NLRP3 STK11 0.8 0.927 0.854 0.826 FGFR2 HFE2 IL10 NFKB1 NLRP3 STK11 0.8 0.927 0.854 0.837 CASP9 GCKR IL10 NFKB1 RGS2 STK11 0.848 0.872 0.854 0.837 CASP9 NLRP1 NR3C1 RGS2 STK11 TGFB1 0.814 0.913 0.854 0.841 ABCA1 HFE MMP13 MUC1 NLRP1 STK11 0.819 0.898 0.854 0.865 HAMP MMP13 MUC1 NLRP1 SDK1 STK11 0.861 0.855 0.854 0.864 CASP9 IL10 NLRP1 PPARG STK11 TGFB1 0.822 0.9 0.854 0.843 CASP3 CCL27 RGS2 SIRT1 SLC40A1 VEGFA 0.819 0.898 0.854 0.817 ABCA1 IL10 IL1B IL6 MUC1 STK11 0.789 0.942 0.854 0.8 CASP9 HAMP MMP13 NFKB2 NLRP1 STK11 0.846 0.871 0.854 0.83 ABCA1 CACNA1C CASP9 HFE MMP13 STK11 0.844 0.869 0.854 0.836 ABCA1 HAMP IL10 MUC1 NFKB1 STK11 0.816 0.898 0.854 0.854 CASP9 HFE IL10 MUC1 NFKB1 STK11 0.816 0.898 0.854 0.844 GH1 IL10 MMP13 NLRP1 SMAD3 STK11 0.853 0.87 0.854 0.87 HFE IL10 MUC1 NFKB2 STK11 VEGFA 0.822 0.898 0.854 0.822 FKBP5 IL6 NFKB1 RGS2 SLC40A1 STK11 0.836 0.884 0.854 0.872 ADAMTS4 CASP9 HAMP IL10 NFKB1 STK11 0.829 0.886 0.854 0.853 CASP9 FKBP5 HAMP IL10 NFKB1 STK11 0.829 0.886 0.854 0.86 CASP9 HAMP IL10 NFKB1 PAX8 STK11 0.829 0.886 0.854 0.839 CD274 HAMP IL10 NFKB1 RGS2 STK11 0.829 0.886 0.854 0.848 GCKR IL10 NFKB1 RGS2 SLC11A2 STK11 0.829 0.886 0.854 0.828 GCKR IL10 MMP13 NFKB1 SLC6A3 STK11 0.83 0.885 0.854 0.853 CASP3 CASP9 HFE MMP13 SLC6A3 STK11 0.836 0.886 0.854 0.824 CASP9 CCL27 FKBP5 RGS2 SLC40A1 STK11 0.809 0.912 0.854 0.841 ABCA1 HAMP IL10 MUC1 STK11 TGFB1 0.815 0.9 0.854 0.808 FKBP5 IGF1 IL10 MUC1 NFKB2 STK11 0.817 0.898 0.854 0.829 FKBP5 IL10 IL1A NFKB1 SLC6A3 STK11 0.818 0.899 0.854 0.83 CASP9 CRHR1 NLRP1 SIRT1 SLC11A2 STK11 0.817 0.899 0.854 0.823 IGF1 IL10 RGS2 SLC40A1 SLC6A3 STK11 0.817 0.9 0.854 0.849 ABCA1 MUC1 SDK1 SLC11A2 STK11 VEGFA 0.786 0.942 0.854 0.833 EPO IL10 KRT83 NFKB1 SLC11A2 STK11 0.832 0.885 0.854 0.841 CCL27 FKBP5 HAMP IL10 STK11 TNF 0.811 0.914 0.854 0.822 CD274 IL10 NFKB1 RGS2 SLC11A2 STK11 0.829 0.885 0.854 0.818 CACNA1C GH1 IL10 NFKB1 STK11 TGFB1 0.836 0.888 0.854 0.837 IL10 IL1B RGS2 SDK1 SLC40A1 SLC6A3 0.764 0.971 0.854 0.855 CASP9 HAMP IL10 NFKB1 SMAD3 STK11 0.828 0.886 0.854 0.864 CRHR1 IL10 NFKB1 PAX8 SMAD3 STK11 0.828 0.885 0.854 0.841 FKBP5 HFE IL10 NFKB1 NFKB2 STK11 0.83 0.884 0.854 0.845 CACNA1C CASP9 EPO RGS2 SLC40A1 STK11 0.807 0.914 0.854 0.841 CASP3 CD274 IL10 MUC1 NFKB1 STK11 0.785 0.942 0.854 0.86 CASP3 IGF1 IL10 MUC1 NFKB1 STK11 0.785 0.942 0.854 0.851 FKBP5 IL10 MMP13 NFKB1 NLRP3 STK11 0.873 0.842 0.854 0.863 IL10 KRT1 MMP13 NFKB1 NLRP3 STK11 0.873 0.842 0.854 0.851 CRHR1 IL10 MUC1 NFKB1 NLRP1 STK11 0.816 0.898 0.854 0.844 CCL27 IL10 NFKB1 SLC11A2 SLC6A3 STK11 0.816 0.9 0.854 0.849 IL10 KRT1 MUC1 NFKB1 STK11 TGFB1 0.817 0.899 0.854 0.858 IL10 NFKB1 RGS2 SLC11A2 SLC6A3 STK11 0.816 0.9 0.854 0.833 CASP1 FKBP5 IL6 NFKB1 SLC40A1 STK11 0.831 0.885 0.854 0.861 CASP9 MMP13 SLC22A4 SLC6A3 STK11 TGFB1 0.855 0.859 0.854 0.845 IL18 NLRP1 SDK1 SIRT1 SLC11A2 STK11 0.857 0.857 0.854 0.851 CASP9 EPO IL10 NLRP1 SDK1 STK11 0.862 0.874 0.854 0.841 GH1 IGF1 IL10 MUC1 NLRP1 STK11 0.806 0.912 0.854 0.821 ABCA1 ADAMTS4 IL10 IL1B MUC1 STK11 0.783 0.942 0.854 0.783 CCL27 IL10 NFKB1 PAX8 SMAD3 STK11 0.828 0.884 0.854 0.839 CRHR1 FKBP5 IL10 NFKB1 STK11 VEGFA 0.828 0.884 0.854 0.849 IL10 MUC1 NFKB1 SIRT1 SKA2 STK11 0.831 0.884 0.854 0.887 IL6 MUC1 RGS2 SLC40A1 STK11 TGFB1 0.828 0.885 0.854 0.865 CRHR1 FKBP5 IL10 MMP13 NFKB1 STK11 0.872 0.843 0.854 0.873 CRHR1 HAMP IL10 MMP13 NFKB1 STK11 0.872 0.843 0.854 0.861 CRHR1 IL10 MMP13 NFKB1 PAX8 STK11 0.872 0.843 0.854 0.869 CASP9 IL10 NFKB1 RGS2 SLC6A3 STK11 0.817 0.9 0.854 0.862 EDAR IL10 MUC1 NFKB1 STK11 TGFB1 0.818 0.899 0.854 0.847 HAMP IL10 NFKB1 NLRP3 SDK1 STK11 0.817 0.898 0.854 0.828 HAMP IL10 NFKB1 NLRP3 SLC11A2 STK11 0.819 0.9 0.854 0.827 IL10 IL6 MUC1 NFKB2 SDK1 STK11 0.816 0.898 0.854 0.831 IL10 MUC1 NFKB1 PAX8 STK11 TGFB1 0.818 0.899 0.854 0.86 IL10 MUC1 NFKB1 SLC40A1 STK11 TNF 0.766 0.971 0.854 0.829 CASP3 IL10 IL1B MUC1 NFKB1 STK11 0.795 0.928 0.854 0.837 HFE2 IL10 MUC1 NFKB2 PAX8 STK11 0.799 0.927 0.854 0.845 CRHR1 HFE MMP13 RGS2 SDK1 SLC40A1 0.775 0.958 0.854 0.824 CASP3 CASP9 EDAR IL10 NR3C1 STK11 0.802 0.929 0.854 0.803 CACNA1C HFE IL10 IL6 NFKB1 STK11 0.857 0.856 0.854 0.848 CASP9 HFE MMP13 SDK1 SLC40A1 STK11 0.854 0.856 0.854 0.846 CCL27 HFE IL10 IL6 NFKB1 STK11 0.856 0.855 0.854 0.855 HFE IL18 NLRP1 SIRT1 SLC11A2 STK11 0.859 0.857 0.854 0.84 IL10 IL1A MMP13 NFKB1 NLRP3 STK11 0.857 0.856 0.854 0.857 CCL27 IL10 NFKB1 PAX8 STK11 VEGFA 0.848 0.87 0.854 0.849 HAMP IL10 KRT83 SMAD3 STK11 TGFB1 0.84 0.886 0.854 0.793 FGFR2 HAMP IL10 SLC22A4 SMAD3 STK11 0.794 0.928 0.854 0.81 IL10 IL18 MUC1 NFKB1 SLC40A1 STK11 0.794 0.928 0.854 0.816 GCKR HFE IL10 IL1B NFKB1 STK11 0.831 0.884 0.854 0.829 CRHR1 IL10 MUC1 NFKB1 NLRP3 STK11 0.818 0.898 0.854 0.862 GH1 HAMP IL10 MUC1 SLC22A4 STK11 0.816 0.899 0.854 0.84 HAMP IL10 MUC1 NLRP1 SLC40A1 STK11 0.816 0.898 0.854 0.834 IL10 NFKB1 PAX8 SLC6A3 SMAD3 STK11 0.817 0.899 0.854 0.848 CCL27 HAMP IL10 NLRP1 STK11 VEGFA 0.793 0.929 0.854 0.813 CD274 EDAR IL10 NFKB1 PAX8 STK11 0.807 0.913 0.854 0.812 CD274 GH1 IL10 NFKB1 PAX8 STK11 0.807 0.913 0.854 0.841 EPO FKBP5 IL10 KRT1 NFKB1 STK11 0.807 0.913 0.854 0.839 FKBP5 GCKR IL10 KRT1 NFKB1 STK11 0.807 0.913 0.854 0.842 FKBP5 IL10 KRT1 NFKB1 PAX8 STK11 0.807 0.913 0.854 0.823 IL10 KRT1 NFKB1 NLRP3 PAX8 STK11 0.807 0.913 0.854 0.828 CASP1 GH1 IL10 MUC1 NFKB2 STK11 0.785 0.942 0.854 0.818 IL10 IL1B MUC1 NFKB1 PAX8 STK11 0.818 0.899 0.854 0.849 IL10 NFKB1 SIRT1 SLC11A2 STK11 VEGFA 0.86 0.857 0.854 0.877 CASP9 IL10 NFKB1 SMAD3 STK11 TGFB1 0.833 0.886 0.854 0.858 CRHR1 IL10 IL6 NFKB1 STK11 TGFB1 0.833 0.886 0.854 0.843 HAMP IL10 NLRP1 RGS2 SDK1 STK11 0.83 0.885 0.854 0.864 ABCA1 CASP9 MMP13 MUC1 RGS2 STK11 0.792 0.928 0.854 0.803 IL10 IL6 MMP13 NFKB1 SLC11A2 STK11 0.873 0.842 0.854 0.847 CRHR1 HFE IL6 MUC1 SDK1 SLC40A1 0.774 0.958 0.854 0.787 FKBP5 IL10 MMP13 NLRP1 SLC11A2 STK11 0.861 0.856 0.854 0.847 IL10 IL1A MMP13 NLRP1 SLC11A2 STK11 0.861 0.856 0.854 0.838 CCL27 IL1A NLRP1 RGS2 SIRT1 TNF 0.819 0.898 0.854 0.851 IL1A MUC1 NLRP1 RGS2 SKA2 STK11 0.862 0.854 0.854 0.821 CASP9 CD274 MUC1 NFKB1 NR3C1 STK11 0.794 0.927 0.854 0.762 CASP9 EDAR MUC1 NFKB1 NR3C1 STK11 0.794 0.927 0.854 0.77 CASP9 EDAR MUC1 NFKB2 NR3C1 STK11 0.794 0.927 0.854 0.781 CASP9 MUC1 NFKB2 NR3C1 RGS2 STK11 0.794 0.927 0.854 0.763 CACNA1C HFE MMP13 MUC1 NLRP1 STK11 0.821 0.896 0.854 0.874 CRHR1 HFE IL10 IL1B NFKB1 STK11 0.829 0.884 0.854 0.835 CASP3 FKBP5 IL10 NFKB1 NLRP1 STK11 0.806 0.913 0.854 0.851 HAMP IL10 IL1A NFKB1 NFKB2 STK11 0.794 0.928 0.854 0.822 IL1B IL6 RGS2 SIRT1 SLC40A1 TNF 0.796 0.927 0.854 0.864 IL18 MUC1 NLRP1 SDK1 SIRT1 STK11 0.82 0.898 0.854 0.815 FKBP5 HFE IL10 IL1B NFKB1 STK11 0.858 0.855 0.854 0.84 HFE KRT83 MMP13 NLRP1 SLC11A2 STK11 0.857 0.854 0.854 0.847 HFE IL10 NFKB1 SIRT1 SLC11A2 STK11 0.875 0.842 0.854 0.867 ADAMTS4 IL10 MUC1 NFKB2 PAX8 STK11 0.816 0.898 0.854 0.835 IL10 MUC1 NFKB2 PAX8 STK11 VEGFA 0.818 0.898 0.854 0.846 HFE NR3C1 SIRT1 SLC11A2 SLC40A1 SMAD3 0.778 0.956 0.854 0.677 FKBP5 IL10 IL6 MUC1 NFKB1 STK11 0.816 0.896 0.854 0.862 CACNA1C CASP9 CCL27 MMP13 PAX8 STK11 0.859 0.859 0.854 0.832 ABCA1 IGF1 IL10 IL1B MUC1 STK11 0.788 0.942 0.854 0.772 CASP9 CD274 CRHR1 RGS2 SLC40A1 STK11 0.809 0.913 0.854 0.807 FKBP5 IL10 MUC1 NFKB2 NR3C1 STK11 0.784 0.941 0.854 0.822 CASP1 HAMP IL10 MMP13 NFKB1 STK11 0.843 0.87 0.854 0.858 CACNA1C MMP13 NLRP1 SDK1 SLC11A2 STK11 0.862 0.856 0.854 0.866 IL10 NFKB1 NLRP3 SDK1 SLC40A1 STK11 0.82 0.9 0.854 0.835 FKBP5 GCKR IL10 MUC1 NLRP1 STK11 0.805 0.912 0.854 0.825 FGFR2 FKBP5 IL10 MUC1 NFKB1 STK11 0.817 0.896 0.854 0.856 FKBP5 NLRP1 SIRT1 SLC11A2 STK11 TNF 0.832 0.885 0.854 0.839 IL10 NFKB1 PAX8 SMAD3 STK11 TGFB1 0.846 0.872 0.854 0.846 CRHR1 IL10 MMP13 NFKB1 NLRP1 SIRT1 0.86 0.857 0.854 0.865 CCL27 IGF1 MMP13 RGS2 SDK1 SLC40A1 0.785 0.956 0.854 0.817 CACNA1C IL10 IL1B MUC1 NFKB1 STK11 0.819 0.899 0.854 0.845 CD274 MUC1 NLRP1 NR3C1 STK11 TNF 0.797 0.927 0.854 0.794 CASP9 GH1 HFE MMP13 SLC6A3 STK11 0.827 0.885 0.854 0.83 CASP9 MMP13 NLRP1 RGS2 STK11 TGFB1 0.896 0.824 0.854 0.893 HFE2 IL10 NLRP1 SKA2 SLC11A2 STK11 0.837 0.885 0.854 0.843 CD274 HFE IL6 NR3C1 STK11 TGFB1 0.796 0.927 0.854 0.794 CASP1 HAMP HFE2 IL10 SLC11A2 STK11 0.8 0.929 0.854 0.815 IL18 MUC1 NLRP1 SLC11A2 SLC6A3 STK11 0.82 0.898 0.854 0.822 IL10 MUC1 NFKB1 PAX8 SLC22A4 STK11 0.818 0.896 0.854 0.84 HFE IL10 KRT83 MUC1 NFKB1 STK11 0.818 0.896 0.854 0.844 CRHR1 HAMP IL10 NLRP1 SLC11A2 STK11 0.796 0.928 0.854 0.824 IL10 IL1B MMP13 RGS2 SLC40A1 TNF 0.809 0.913 0.854 0.869 IL6 MUC1 NFKB1 NLRP1 NR3C1 STK11 0.799 0.926 0.854 0.768 CASP9 MMP13 NLRP1 RGS2 SIRT1 STK11 0.861 0.855 0.854 0.9 EDAR IL10 MUC1 NFKB2 NLRP1 STK11 0.806 0.912 0.854 0.819 IL10 MUC1 NFKB1 SIRT1 SLC40A1 STK11 0.794 0.928 0.854 0.855 IL10 MUC1 NFKB1 SIRT1 SLC22A4 STK11 0.794 0.928 0.854 0.874 IL10 IL6 NFKB1 NLRP3 SLC22A4 STK11 0.828 0.885 0.854 0.834 CASP9 GCKR HAMP IL10 NFKB2 STK11 0.825 0.886 0.854 0.859 CASP9 HAMP IL10 NFKB2 STK11 VEGFA 0.825 0.886 0.854 0.845 CRHR1 MMP13 MUC1 NLRP1 SDK1 STK11 0.898 0.826 0.854 0.865 CASP9 IL6 NLRP1 RGS2 SLC40A1 STK11 0.843 0.884 0.854 0.849 ABCA1 CASP9 FKBP5 RGS2 SLC40A1 STK11 0.804 0.913 0.854 0.837 CASP9 FGFR2 FKBP5 RGS2 SLC40A1 STK11 0.804 0.913 0.854 0.832 CASP9 FKBP5 RGS2 SLC11A2 SLC40A1 STK11 0.804 0.913 0.854 0.837 CASP9 PAX8 RGS2 SLC40A1 SLC6A3 STK11 0.804 0.913 0.854 0.816 EPO HAMP IL10 NFKB1 SLC6A3 STK11 0.792 0.928 0.854 0.851 CASP3 CASP9 IL10 NFKB1 STK11 TGFB1 0.827 0.885 0.854 0.856 CRHR1 GCKR IL10 KRT83 NFKB1 STK11 0.828 0.885 0.854 0.843 IL10 IL1A NFKB1 SLC11A2 STK11 VEGFA 0.829 0.885 0.854 0.837 IL10 IL6 NFKB2 SIRT1 SLC11A2 STK11 0.83 0.886 0.854 0.845 IL10 NFKB1 PAX8 SLC11A2 STK11 TNF 0.831 0.885 0.854 0.814 IL10 NFKB2 SKA2 SLC11A2 STK11 VEGFA 0.829 0.885 0.854 0.855 IL6 RGS2 SDK1 SLC40A1 STK11 TGFB1 0.828 0.886 0.854 0.886 ADAMTS4 CD274 IL10 NFKB1 SLC11A2 STK11 0.829 0.885 0.854 0.834 ADAMTS4 IL10 IL6 NFKB1 SLC11A2 STK11 0.829 0.885 0.854 0.837 ADAMTS4 IL10 NFKB1 SLC11A2 STK11 TNF 0.829 0.885 0.854 0.835 CASP3 IL10 NFKB1 PAX8 SLC11A2 STK11 0.829 0.885 0.854 0.834 CASP9 HAMP IL10 NFKB1 STK11 TNF 0.828 0.886 0.854 0.85 FKBP5 IL10 NFKB1 NFKB2 SLC11A2 STK11 0.829 0.885 0.854 0.839 IL10 KRT1 NFKB1 NFKB2 SLC11A2 STK11 0.83 0.886 0.854 0.812 CASP9 IL18 MMP13 NLRP1 SLC11A2 STK11 0.826 0.888 0.854 0.869 EDAR HAMP IL10 MUC1 NFKB1 STK11 0.828 0.884 0.854 0.856 HAMP IL10 MUC1 NFKB1 SKA2 STK11 0.828 0.884 0.854 0.872 FGFR2 MUC1 NLRP1 NR3C1 SLC6A3 STK11 0.796 0.926 0.854 0.758 CASP9 HAMP IL10 MUC1 NFKB2 STK11 0.816 0.9 0.854 0.842 ABCA1 GH1 IL10 MUC1 STK11 TGFB1 0.817 0.899 0.854 0.816 GCKR IL10 MMP13 NFKB1 NLRP1 STK11 0.844 0.871 0.854 0.856 IL10 MMP13 NFKB1 NLRP1 SLC6A3 STK11 0.844 0.871 0.854 0.856 IL10 MMP13 NFKB1 SLC22A4 SLC6A3 STK11 0.844 0.871 0.854 0.861 EPO HAMP IL10 MUC1 NFKB1 STK11 0.815 0.896 0.854 0.866 IL1B IL6 MMP13 RGS2 SLC40A1 STK11 0.912 0.811 0.854 0.896 CASP9 CRHR1 MMP13 NLRP1 RGS2 STK11 0.884 0.84 0.854 0.896 CASP9 CRHR1 GH1 MMP13 NLRP1 STK11 0.828 0.886 0.854 0.851 GH1 IL10 NFKB2 SIRT1 SLC11A2 STK11 0.835 0.888 0.854 0.835 HFE IL10 NLRP1 SLC11A2 STK11 TNF 0.835 0.885 0.854 0.855 IL10 IL18 NLRP3 NR3C1 STK11 TGFB1 0.795 0.927 0.854 0.789 CASP9 CCL27 IL10 KRT1 NLRP1 STK11 0.862 0.857 0.854 0.862 CASP9 IL10 NFKB1 NFKB2 STK11 TGFB1 0.829 0.886 0.854 0.858 CASP9 IL10 NFKB1 STK11 TGFB1 VEGFA 0.829 0.886 0.854 0.865 CCL27 FKBP5 IL10 NFKB1 SLC40A1 STK11 0.828 0.885 0.854 0.842 FGFR2 IL10 MMP13 NFKB1 SKA2 STK11 0.87 0.842 0.854 0.849 CASP9 FKBP5 MMP13 NLRP1 SLC11A2 STK11 0.826 0.886 0.854 0.879 ABCA1 CCL27 IL10 IL18 SIRT1 TNF 0.785 0.943 0.854 0.798 CACNA1C IGF1 IL10 NFKB1 PAX8 STK11 0.806 0.913 0.854 0.831 CACNA1C IL10 NFKB1 NLRP1 PAX8 STK11 0.806 0.913 0.854 0.844 CD274 FGFR2 IL10 NFKB1 PAX8 STK11 0.835 0.883 0.854 0.838 EPO GH1 IL10 NFKB1 NLRP1 STK11 0.807 0.914 0.854 0.842 GCKR IL10 NFKB1 SDK1 SLC11A2 STK11 0.843 0.871 0.854 0.846 IGF1 IL10 NFKB1 NFKB2 PAX8 STK11 0.806 0.913 0.854 0.837 ADAMTS4 IL10 IL6 MUC1 NFKB1 STK11 0.816 0.896 0.854 0.842 CCL27 IL10 KRT1 NFKB1 SLC6A3 STK11 0.816 0.9 0.854 0.845 FGFR2 IL10 MUC1 NFKB1 SKA2 STK11 0.816 0.896 0.854 0.863 HFE2 IL10 MUC1 NFKB1 SLC11A2 STK11 0.816 0.896 0.854 0.836 ADAMTS4 CRHR1 IL10 MMP13 NFKB1 STK11 0.869 0.843 0.854 0.86 IL10 IL1B MMP13 RGS2 SLC40A1 STK11 0.87 0.841 0.854 0.901 HFE2 MMP13 RGS2 SLC40A1 STK11 TGFB1 0.871 0.842 0.854 0.865 ABCA1 CASP9 KRT83 RGS2 SLC40A1 STK11 0.805 0.914 0.854 0.834 ABCA1 GCKR IL10 IL6 MUC1 STK11 0.782 0.941 0.854 0.789 ABCA1 HAMP IL10 MUC1 SDK1 STK11 0.793 0.928 0.854 0.811 CASP9 KRT83 RGS2 SLC22A4 SLC40A1 STK11 0.805 0.914 0.854 0.837 HFE IL6 MMP13 MUC1 NFKB1 STK11 0.857 0.854 0.854 0.849 MUC1 RGS2 SKA2 SLC40A1 STK11 TGFB1 0.827 0.884 0.854 0.851 CD274 NLRP1 RGS2 SDK1 SLC40A1 SLC6A3 0.746 1 0.854 0.72 HFE IL6 RGS2 SDK1 SLC40A1 SLC6A3 0.746 1 0.854 0.777 IL10 IL1A NFKB1 SLC6A3 STK11 TGFB1 0.835 0.886 0.854 0.85 ADAMTS4 IL10 MMP13 NFKB1 STK11 TGFB1 0.868 0.843 0.854 0.863 CD274 HFE IL6 MUC1 NR3C1 SLC40A1 0.791 0.943 0.854 0.694 CASP9 FKBP5 HFE RGS2 SLC40A1 STK11 0.807 0.913 0.854 0.839 ABCA1 CASP9 MMP13 SLC6A3 STK11 TGFB1 0.855 0.857 0.854 0.821 GH1 IL6 RGS2 SDK1 SLC40A1 STK11 0.816 0.898 0.854 0.854 CASP3 IL10 NFKB1 NFKB2 PAX8 STK11 0.805 0.913 0.854 0.835 EDAR IL10 NFKB1 NLRP1 PAX8 STK11 0.805 0.913 0.854 0.828 GH1 IL10 NFKB1 NFKB2 PAX8 STK11 0.805 0.913 0.854 0.839 IL10 MMP13 NFKB1 SDK1 STK11 TGFB1 0.842 0.871 0.854 0.874 IL10 NFKB1 NLRP1 PAX8 STK11 VEGFA 0.805 0.913 0.854 0.853 CCL27 IL10 NFKB1 NLRP3 PPARG STK11 0.793 0.928 0.854 0.809 FKBP5 IL10 KRT1 NFKB1 NLRP1 STK11 0.805 0.913 0.854 0.839 FKBP5 HFE2 MUC1 NLRP1 RGS2 STK11 0.819 0.896 0.854 0.815 FKBP5 GH1 MMP13 RGS2 SLC40A1 STK11 0.829 0.883 0.854 0.868 ABCA1 CRHR1 IL10 MMP13 MUC1 STK11 0.795 0.929 0.854 0.834 CASP9 PAX8 RGS2 SLC40A1 STK11 VEGFA 0.818 0.9 0.854 0.824 CACNA1C CCL27 MUC1 RGS2 SDK1 SLC40A1 0.77 0.97 0.854 0.786 CASP9 CCL27 MUC1 RGS2 SDK1 SLC40A1 0.77 0.97 0.854 0.772 CCL27 HAMP MUC1 RGS2 SDK1 SLC40A1 0.77 0.97 0.854 0.763 CCL27 HFE2 MUC1 RGS2 SDK1 SLC40A1 0.77 0.97 0.854 0.791 CD274 GCKR IL10 MUC1 NFKB1 STK11 0.794 0.927 0.854 0.858 IL1B MMP13 RGS2 SDK1 SKA2 SLC40A1 0.794 0.928 0.854 0.853 CCL27 IL10 NFKB1 NLRP3 SLC6A3 STK11 0.819 0.9 0.854 0.829 IL10 IL1B IL6 MUC1 NFKB1 STK11 0.834 0.884 0.854 0.848 CASP9 IL1A RGS2 SDK1 SLC40A1 STK11 0.799 0.928 0.854 0.821 IL10 IL18 MMP13 NFKB1 NLRP1 STK11 0.863 0.857 0.854 0.838 CASP9 IL10 IL6 NFKB1 STK11 TGFB1 0.868 0.859 0.854 0.865 CCL27 IL10 NFKB1 RGS2 SIRT1 SLC40A1 0.822 0.899 0.853 0.839 ABCA1 EPO IL6 RGS2 SIRT1 SLC40A1 0.783 0.955 0.853 0.82 IL10 IL6 RGS2 SDK1 SIRT1 SLC40A1 0.764 0.971 0.853 0.81 CASP1 FKBP5 HAMP IL10 SLC11A2 STK11 0.799 0.929 0.853 0.824 CASP9 CD274 IL10 MUC1 NFKB1 STK11 0.796 0.929 0.853 0.855 CASP9 IL10 KRT1 MUC1 NFKB2 STK11 0.794 0.929 0.853 0.8 CRHR1 IGF1 IL10 MMP13 NFKB1 SIRT1 0.857 0.857 0.853 0.852 IL10 IL1A MUC1 NFKB2 NLRP1 STK11 0.817 0.899 0.853 0.829 CCL27 IL10 MMP13 RGS2 SIRT1 SLC40A1 0.833 0.885 0.853 0.856 CASP9 CCL27 HAMP HFE2 IL10 STK11 0.818 0.902 0.853 0.838 HAMP IL10 NLRP1 RGS2 SLC11A2 STK11 0.818 0.899 0.853 0.862 CASP1 NLRP1 SDK1 SIRT1 SLC11A2 STK11 0.867 0.841 0.853 0.838 ABCA1 CASP3 FKBP5 IL6 RGS2 SLC40A1 0.758 0.985 0.853 0.69 ABCA1 CASP3 IL6 NLRP1 RGS2 SLC40A1 0.758 0.985 0.853 0.688 CASP9 HFE2 MMP13 MUC1 NLRP1 STK11 0.829 0.885 0.853 0.871 CD274 FGFR2 IL10 NFKB1 SLC11A2 STK11 0.83 0.884 0.853 0.831 FGFR2 IL10 KRT1 NFKB1 SLC11A2 STK11 0.83 0.884 0.853 0.848 FKBP5 HFE2 IL10 KRT83 NFKB1 STK11 0.831 0.883 0.853 0.851 CCL27 IL18 MMP13 NLRP1 SDK1 TGFB1 0.827 0.885 0.853 0.806 CCL27 MMP13 NLRP1 SDK1 SKA2 TGFB1 0.827 0.885 0.853 0.809 EPO GH1 MUC1 NR3C1 PAX8 SLC40A1 0.798 0.926 0.853 0.668 CASP3 CRHR1 HFE IL10 NFKB1 STK11 0.829 0.885 0.853 0.867 CCL27 HFE MMP13 SLC11A2 SLC40A1 STK11 0.829 0.886 0.853 0.827 IL1B IL6 PPARG RGS2 SLC40A1 STK11 0.874 0.841 0.853 0.87 FKBP5 IL1A MUC1 NLRP1 PAX8 STK11 0.817 0.899 0.853 0.81 CASP9 IL10 NLRP1 SDK1 STK11 TGFB1 0.882 0.845 0.853 0.864 FKBP5 IL18 NLRP1 SIRT1 SLC11A2 STK11 0.857 0.857 0.853 0.841 FGFR2 HAMP IL10 NLRP1 PAX8 STK11 0.793 0.928 0.853 0.797 HFE IL10 IL6 NFKB1 NFKB2 STK11 0.83 0.884 0.853 0.845 CASP9 CD274 HFE MMP13 SLC40A1 STK11 0.828 0.886 0.853 0.834 CCL27 IL1B MUC1 NLRP1 SDK1 STK11 0.84 0.883 0.853 0.823 EPO FKBP5 IL10 NLRP1 SLC11A2 STK11 0.835 0.886 0.853 0.847 GH1 IL10 NFKB2 RGS2 SLC11A2 STK11 0.838 0.888 0.853 0.825 CACNA1C FKBP5 IL1B IL6 RGS2 SLC40A1 0.774 0.956 0.853 0.8 EDAR FKBP5 IL1B IL6 RGS2 SLC40A1 0.774 0.956 0.853 0.804 FKBP5 GCKR IL1B IL6 RGS2 SLC40A1 0.774 0.956 0.853 0.797 FKBP5 HAMP IL1B IL6 RGS2 SLC40A1 0.774 0.956 0.853 0.791 FKBP5 HFE2 IL1B IL6 RGS2 SLC40A1 0.774 0.956 0.853 0.802 FKBP5 IL1B IL6 NFKB1 RGS2 SLC40A1 0.774 0.956 0.853 0.798 FKBP5 IL1B IL6 NFKB2 RGS2 SLC40A1 0.774 0.956 0.853 0.804 FKBP5 IL1B IL6 RGS2 SLC40A1 VEGFA 0.774 0.956 0.853 0.795 CASP9 IL10 NLRP1 RGS2 SLC40A1 STK11 0.842 0.871 0.853 0.849 CASP9 IL10 RGS2 SLC22A4 SLC40A1 STK11 0.842 0.871 0.853 0.853 CASP9 CRHR1 NLRP1 RGS2 SLC40A1 STK11 0.812 0.912 0.853 0.837 CASP9 IGF1 NLRP1 RGS2 SLC40A1 STK11 0.812 0.912 0.853 0.835 CASP9 KRT83 NLRP1 RGS2 SLC40A1 STK11 0.812 0.912 0.853 0.848 CASP9 NLRP1 RGS2 SLC22A4 SLC40A1 STK11 0.812 0.912 0.853 0.844 HFE IL10 MUC1 NFKB1 RGS2 STK11 0.817 0.896 0.853 0.849 CD274 IL10 MMP13 NFKB1 NLRP1 STK11 0.85 0.87 0.853 0.839 CCL27 IL18 RGS2 SIRT1 SLC22A4 TGFB1 0.782 0.941 0.853 0.773 ABCA1 HAMP HFE IL10 MUC1 STK11 0.791 0.928 0.853 0.809 CASP9 IL10 MUC1 NFKB1 NR3C1 STK11 0.794 0.927 0.853 0.823 CASP9 EPO IL10 MMP13 NLRP1 STK11 0.881 0.842 0.853 0.862 FKBP5 IL10 NFKB1 SLC6A3 STK11 TGFB1 0.827 0.886 0.853 0.849 MMP13 NLRP1 NLRP3 SLC11A2 STK11 VEGFA 0.858 0.857 0.853 0.851 ABCA1 CACNA1C HAMP IL10 MUC1 STK11 0.791 0.928 0.853 0.797 ABCA1 HAMP IL10 MUC1 SLC40A1 STK11 0.792 0.927 0.853 0.83 ABCA1 IL10 MUC1 NFKB1 SIRT1 STK11 0.793 0.928 0.853 0.863 IL10 NFKB2 NLRP3 PAX8 SLC11A2 STK11 0.793 0.929 0.853 0.829 ABCA1 CASP3 CASP9 IL10 NFKB1 STK11 0.79 0.928 0.853 0.849 GH1 IL10 MUC1 NFKB1 SMAD3 STK11 0.793 0.927 0.853 0.849 IL10 MUC1 NFKB1 SMAD3 STK11 TNF 0.793 0.927 0.853 0.859 CASP1 FGFR2 IL10 NFKB1 PAX8 STK11 0.849 0.867 0.853 0.827 CASP9 EDAR IL10 MMP13 NLRP1 STK11 0.872 0.859 0.853 0.854 CASP9 CCL27 IL6 PAX8 SLC11A2 STK11 0.862 0.859 0.853 0.81 CRHR1 GCKR IL10 KRT1 NFKB1 STK11 0.827 0.885 0.853 0.855 CRHR1 HFE IL10 MUC1 NFKB1 STK11 0.827 0.885 0.853 0.869 FKBP5 IL10 NFKB1 NFKB2 STK11 VEGFA 0.845 0.87 0.853 0.851 HFE2 IL10 NFKB1 PAX8 SLC11A2 STK11 0.828 0.884 0.853 0.852 ADAMTS4 NFKB2 SIRT1 SLC11A2 STK11 VEGFA 0.792 0.928 0.853 0.798 IL10 IL18 MUC1 NFKB1 STK11 TGFB1 0.792 0.929 0.853 0.842 CASP3 CRHR1 MMP13 MUC1 NLRP1 SDK1 0.839 0.885 0.853 0.849 GCKR IL10 RGS2 SKA2 SLC40A1 STK11 0.793 0.927 0.853 0.872 IL10 MMP13 NLRP1 NLRP3 SIRT1 STK11 0.83 0.902 0.853 0.842 CACNA1C CASP1 CASP9 MMP13 SKA2 STK11 0.864 0.859 0.853 0.811 CACNA1C HAMP IL10 NFKB1 SLC11A2 STK11 0.829 0.886 0.853 0.849 CASP3 CRHR1 IL10 NFKB1 SLC11A2 STK11 0.827 0.886 0.853 0.846 CASP9 IL10 IL6 NFKB1 SKA2 STK11 0.864 0.859 0.853 0.853 CCL27 HFE IL1A IL6 NFKB1 STK11 0.856 0.854 0.853 0.86 CRHR1 GCKR IL10 NFKB1 SLC11A2 STK11 0.827 0.886 0.853 0.846 FKBP5 IL10 NFKB1 NLRP1 SLC11A2 STK11 0.827 0.884 0.853 0.845 FKBP5 HAMP IL10 NFKB1 STK11 TGFB1 0.818 0.9 0.853 0.853 IL10 RGS2 SKA2 SLC40A1 STK11 TNF 0.793 0.927 0.853 0.87 CCL27 HFE RGS2 SDK1 SLC40A1 STK11 0.839 0.884 0.853 0.878 IL10 MUC1 NFKB2 NLRP1 SLC22A4 STK11 0.805 0.91 0.853 0.833 CACNA1C CASP9 EPO IL10 NLRP1 STK11 0.849 0.872 0.853 0.855 CASP1 IL10 IL6 NR3C1 SLC11A2 STK11 0.775 0.957 0.853 0.768 CASP1 IL10 NR3C1 RGS2 SLC11A2 STK11 0.775 0.957 0.853 0.78 CASP9 IL10 NLRP1 SLC11A2 STK11 TGFB1 0.86 0.857 0.853 0.874 FKBP5 IL1B SDK1 SLC11A2 SLC40A1 STK11 0.772 0.958 0.853 0.727 HFE HFE2 IL10 MUC1 NFKB1 STK11 0.815 0.896 0.853 0.849 IL10 KRT83 MUC1 NFKB1 STK11 TGFB1 0.816 0.898 0.853 0.851 CACNA1C HFE IL10 NFKB1 SLC11A2 STK11 0.868 0.842 0.853 0.837 FGFR2 HAMP HFE IL10 RGS2 STK11 0.818 0.915 0.853 0.794 CACNA1C CASP9 IL10 IL1B NFKB1 STK11 0.803 0.914 0.853 0.825 HAMP HFE2 IL10 MUC1 NLRP1 STK11 0.816 0.898 0.853 0.836 CCL27 IL18 MUC1 NLRP1 SLC6A3 STK11 0.793 0.927 0.853 0.818 CASP9 CCL27 MMP13 NLRP1 RGS2 STK11 0.881 0.84 0.853 0.876 CASP9 FKBP5 IL10 NLRP1 RGS2 STK11 0.865 0.856 0.853 0.873 GH1 IL10 MUC1 NFKB1 STK11 VEGFA 0.792 0.927 0.853 0.842 CASP3 CASP9 CRHR1 IL10 NFKB1 STK11 0.828 0.886 0.853 0.86 CASP9 IL10 IL6 NFKB1 PAX8 STK11 0.828 0.886 0.853 0.849 CASP9 IL10 NFKB1 SLC6A3 STK11 TGFB1 0.828 0.886 0.853 0.863 CRHR1 FKBP5 GCKR IL10 NFKB1 STK11 0.825 0.884 0.853 0.853 CASP9 HFE2 IL10 NFKB1 RGS2 STK11 0.828 0.884 0.853 0.849 GH1 IL1B MMP13 RGS2 SLC40A1 TNF 0.793 0.927 0.853 0.825 IL10 MUC1 NFKB2 PAX8 SLC40A1 STK11 0.793 0.928 0.853 0.817 CACNA1C CASP9 MMP13 NLRP1 SLC11A2 STK11 0.826 0.885 0.853 0.89 CASP9 CCL27 GCKR RGS2 STK11 TGFB1 0.81 0.914 0.853 0.766 CCL27 HFE2 IL10 SLC11A2 SLC22A4 STK11 0.813 0.914 0.853 0.82 CCL27 GH1 IL10 MUC1 NLRP1 STK11 0.816 0.899 0.853 0.852 ABCA1 HFE MMP13 MUC1 STK11 VEGFA 0.791 0.927 0.853 0.822 ABCA1 IL10 KRT1 MUC1 NFKB2 STK11 0.791 0.928 0.853 0.812 FKBP5 IL10 IL18 NFKB1 NLRP1 STK11 0.803 0.914 0.853 0.844 CASP9 IL10 NFKB1 RGS2 SIRT1 STK11 0.865 0.842 0.853 0.876 CACNA1C GCKR IL10 NFKB1 SLC11A2 STK11 0.83 0.886 0.853 0.84 CASP9 NLRP1 SIRT1 SKA2 SLC11A2 STK11 0.83 0.886 0.853 0.854 HAMP IL10 NFKB1 SDK1 SLC6A3 STK11 0.825 0.885 0.853 0.847 IL6 PPARG RGS2 SLC40A1 STK11 TGFB1 0.839 0.871 0.853 0.869 ABCA1 KRT1 MUC1 NLRP1 SDK1 STK11 0.833 0.883 0.853 0.845 ADAMTS4 MUC1 NR3C1 SLC40A1 STK11 TNF 0.804 0.913 0.853 0.751 CASP9 GH1 MUC1 NR3C1 SLC40A1 STK11 0.804 0.913 0.853 0.768 HFE HFE2 IL10 NLRP1 SLC11A2 STK11 0.832 0.885 0.853 0.846 CASP9 IL10 IL1B NR3C1 PAX8 STK11 0.806 0.913 0.853 0.8 CD274 IL10 KRT1 MUC1 NFKB1 STK11 0.792 0.927 0.853 0.842 CCL27 KRT1 RGS2 SDK1 SLC40A1 VEGFA 0.784 0.955 0.853 0.783 CASP9 CCL27 IL10 NFKB1 SIRT1 STK11 0.868 0.843 0.853 0.889 IL10 MMP13 NFKB2 SLC11A2 STK11 VEGFA 0.87 0.843 0.853 0.855 ABCA1 CD274 IL10 NFKB1 SDK1 SIRT1 0.813 0.898 0.853 0.84 CACNA1C CRHR1 GCKR IL10 NFKB1 STK11 0.825 0.884 0.853 0.848 CCL27 HAMP IL10 SLC11A2 SLC22A4 STK11 0.793 0.929 0.853 0.86 EPO HAMP IL10 NLRP1 SMAD3 STK11 0.791 0.928 0.853 0.819 MUC1 NLRP1 RGS2 SLC40A1 STK11 TGFB1 0.804 0.913 0.853 0.842 MUC1 NR3C1 RGS2 SLC40A1 STK11 TNF 0.804 0.913 0.853 0.793 CRHR1 IL10 NFKB1 PAX8 SKA2 STK11 0.842 0.872 0.853 0.848 IL18 IL1B MMP13 NLRP1 SLC11A2 STK11 0.839 0.872 0.853 0.85 CCL27 HAMP IL10 NFKB1 SLC11A2 STK11 0.83 0.885 0.853 0.845 GCKR IL10 MMP13 MUC1 NFKB1 STK11 0.83 0.885 0.853 0.888 HFE IL10 MUC1 NFKB1 STK11 VEGFA 0.827 0.884 0.853 0.872 FKBP5 IL18 MUC1 NLRP1 SLC6A3 STK11 0.791 0.927 0.853 0.823 ABCA1 IL6 MUC1 NR3C1 SLC40A1 TGFB1 0.775 0.956 0.853 0.683 CRHR1 IL10 KRT1 NFKB1 NLRP3 STK11 0.83 0.885 0.853 0.839 EPO HFE MMP13 MUC1 NLRP1 STK11 0.827 0.884 0.853 0.879 CASP9 CCL27 MMP13 SLC11A2 STK11 VEGFA 0.822 0.902 0.853 0.822 CASP9 IL10 NFKB1 NLRP1 SLC11A2 STK11 0.803 0.914 0.853 0.874 HAMP IL10 IL18 IL1A NFKB1 STK11 0.856 0.857 0.853 0.832 CASP9 CCL27 HFE RGS2 SDK1 SLC40A1 0.755 0.986 0.853 0.791 ADAMTS4 IL1B MMP13 RGS2 SDK1 SLC40A1 0.794 0.927 0.853 0.851 CACNA1C IGF1 IL10 MUC1 NFKB2 STK11 0.793 0.927 0.853 0.81 CASP1 IL10 MUC1 NFKB1 RGS2 STK11 0.794 0.927 0.853 0.844 NLRP1 RGS2 SDK1 SLC40A1 SMAD3 STK11 0.827 0.896 0.853 0.867 ABCA1 HFE MUC1 NLRP1 SDK1 STK11 0.828 0.896 0.853 0.857 CASP3 IL10 MMP13 NFKB1 SIRT1 STK11 0.869 0.842 0.853 0.863 HFE IL10 NFKB1 SMAD3 STK11 VEGFA 0.843 0.869 0.853 0.846 CASP9 GCKR HFE2 IL10 NFKB1 STK11 0.829 0.886 0.853 0.877 CASP3 CASP9 EDAR RGS2 SLC40A1 STK11 0.817 0.899 0.853 0.833 IL10 NFKB2 SIRT1 SLC11A2 SMAD3 STK11 0.824 0.902 0.853 0.838 GCKR IL10 MUC1 NFKB1 SDK1 STK11 0.828 0.884 0.853 0.878 HFE IL10 SKA2 SLC6A3 STK11 TGFB1 0.854 0.872 0.853 0.855 HAMP HFE IL10 MUC1 SLC22A4 STK11 0.814 0.898 0.853 0.847 CASP9 IL6 KRT83 NFKB2 STK11 TGFB1 0.831 0.886 0.853 0.816 EDAR IL10 KRT1 NFKB2 SLC11A2 STK11 0.831 0.886 0.853 0.811 CACNA1C CCL27 RGS2 SIRT1 TGFB1 TNF 0.785 0.943 0.853 0.774 CACNA1C IL10 NFKB1 SLC11A2 STK11 TGFB1 0.846 0.872 0.853 0.855 CASP3 IL10 NFKB1 SLC11A2 STK11 TGFB1 0.846 0.872 0.853 0.847 CACNA1C MMP13 RGS2 SLC40A1 SLC6A3 STK11 0.831 0.884 0.853 0.869 CASP1 MMP13 MUC1 NLRP1 STK11 TGFB1 0.851 0.87 0.853 0.833 HFE KRT1 MMP13 NLRP1 SLC11A2 STK11 0.868 0.841 0.853 0.853 CASP9 IL10 NFKB1 NR3C1 SLC22A4 STK11 0.805 0.913 0.853 0.824 CASP9 IL10 NR3C1 SLC22A4 STK11 TGFB1 0.805 0.913 0.853 0.847 HFE IL1B RGS2 SKA2 SLC40A1 SLC6A3 0.772 0.956 0.853 0.823 EPO MUC1 NLRP1 NR3C1 STK11 TNF 0.807 0.912 0.853 0.786 MUC1 NLRP1 NR3C1 PAX8 STK11 TNF 0.807 0.912 0.853 0.771 HFE2 IL10 NFKB1 SLC11A2 STK11 TGFB1 0.819 0.9 0.853 0.858 FKBP5 IL1A MUC1 NLRP1 RGS2 STK11 0.825 0.884 0.853 0.837 HAMP IL10 NLRP1 SKA2 SMAD3 STK11 0.83 0.885 0.853 0.804 FKBP5 IL10 NFKB1 NFKB2 SLC40A1 STK11 0.804 0.914 0.853 0.837 FKBP5 IL10 NFKB1 NLRP1 SLC40A1 STK11 0.804 0.914 0.853 0.84 IL1B IL6 MMP13 PPARG RGS2 SLC40A1 0.803 0.913 0.853 0.835 ABCA1 HFE IL6 MMP13 SLC11A2 STK11 0.827 0.883 0.853 0.839 HAMP IL10 IL6 MUC1 NFKB1 STK11 0.827 0.883 0.853 0.874 CCL27 IL18 RGS2 SLC40A1 STK11 VEGFA 0.818 0.898 0.853 0.832 CACNA1C CASP9 IL10 NLRP1 NR3C1 STK11 0.805 0.914 0.853 0.83 CASP9 IL10 NLRP1 NR3C1 SLC11A2 STK11 0.805 0.914 0.853 0.845 CASP9 IL10 NLRP1 NR3C1 SLC22A4 STK11 0.805 0.914 0.853 0.828 ABCA1 CCL27 CD274 IL10 SIRT1 TNF 0.793 0.928 0.853 0.783 CASP9 GH1 MMP13 NLRP1 STK11 TGFB1 0.867 0.842 0.853 0.844 CASP9 IL1B NLRP1 SLC11A2 STK11 TGFB1 0.788 0.943 0.853 0.76 CCL27 MMP13 RGS2 SDK1 SLC40A1 VEGFA 0.787 0.942 0.853 0.825 MMP13 NLRP1 SIRT1 SLC11A2 STK11 TGFB1 0.872 0.841 0.853 0.856 CASP1 RGS2 SDK1 SLC40A1 STK11 TGFB1 0.84 0.871 0.853 0.881 HAMP HFE IL10 MMP13 NFKB2 STK11 0.843 0.871 0.853 0.851 FGFR2 GH1 MUC1 NR3C1 PAX8 SLC40A1 0.798 0.924 0.853 0.682 GCKR GH1 MUC1 NR3C1 PAX8 SLC40A1 0.798 0.924 0.853 0.694 GH1 MUC1 NR3C1 PAX8 SLC22A4 SLC40A1 0.798 0.924 0.853 0.682 GH1 MUC1 NR3C1 PAX8 SLC40A1 TNF 0.798 0.924 0.853 0.677 GH1 MUC1 NR3C1 PAX8 SLC40A1 VEGFA 0.798 0.924 0.853 0.676 ADAMTS4 HFE MMP13 NLRP1 SLC11A2 STK11 0.868 0.84 0.853 0.851 IL18 IL1A MUC1 NLRP1 SLC6A3 STK11 0.792 0.927 0.853 0.813 CASP3 CASP9 MMP13 MUC1 NLRP1 STK11 0.828 0.885 0.853 0.863 CASP9 IL6 NLRP1 SDK1 SLC11A2 STK11 0.83 0.885 0.853 0.855 ABCA1 HAMP IL10 MUC1 PAX8 STK11 0.79 0.928 0.853 0.813 IL1A NLRP1 NLRP3 SIRT1 SLC11A2 STK11 0.844 0.871 0.853 0.822 IL10 MMP13 NLRP1 NLRP3 SLC11A2 STK11 0.856 0.857 0.853 0.858 CASP9 GH1 IL10 NLRP1 NR3C1 STK11 0.805 0.913 0.853 0.825 CASP1 CRHR1 NLRP1 RGS2 SIRT1 SLC40A1 0.783 0.942 0.853 0.783 FKBP5 HAMP IL10 IL6 NFKB1 STK11 0.826 0.883 0.853 0.844 CCL27 FKBP5 IL10 NFKB1 STK11 TNF 0.845 0.87 0.853 0.837 FGFR2 FKBP5 MMP13 NLRP1 RGS2 STK11 0.875 0.838 0.853 0.855 CASP1 HAMP IL10 SLC11A2 SMAD3 STK11 0.792 0.928 0.853 0.834 FGFR2 IL10 MMP13 NFKB1 SLC6A3 STK11 0.84 0.871 0.853 0.867 HFE IL10 NFKB1 PPARG STK11 VEGFA 0.839 0.87 0.853 0.821 IL10 MMP13 NFKB1 SKA2 SLC6A3 STK11 0.84 0.871 0.853 0.851 HFE MMP13 NLRP1 PAX8 SLC11A2 STK11 0.869 0.84 0.853 0.844 CACNA1C IL1B IL6 RGS2 SIRT1 SLC40A1 0.796 0.926 0.853 0.851 CCL27 MMP13 NLRP1 SDK1 SLC11A2 STK11 0.889 0.826 0.853 0.862 CASP9 IGF1 IL10 NFKB1 STK11 TGFB1 0.825 0.886 0.853 0.847 HAMP IL10 KRT83 NFKB1 SLC11A2 STK11 0.827 0.885 0.853 0.838 CASP1 IL10 MMP13 NLRP1 STK11 TGFB1 0.833 0.885 0.853 0.829 ABCA1 CASP1 HAMP IL10 MUC1 STK11 0.79 0.927 0.853 0.782 ABCA1 CASP9 IL10 MUC1 NFKB2 STK11 0.793 0.929 0.853 0.83 ABCA1 CD274 HAMP IL10 MUC1 STK11 0.791 0.928 0.853 0.808 ABCA1 HAMP IL10 MUC1 SLC11A2 STK11 0.791 0.928 0.853 0.801 CASP3 CASP9 GH1 IL10 NFKB1 STK11 0.802 0.914 0.853 0.847 CCL27 CRHR1 MMP13 RGS2 SDK1 SLC40A1 0.786 0.942 0.853 0.859 IL18 NFKB2 SIRT1 SLC11A2 STK11 VEGFA 0.791 0.928 0.853 0.81 GH1 IL6 NR3C1 RGS2 SKA2 SLC40A1 0.756 0.985 0.853 0.699 GH1 IL6 RGS2 SKA2 SLC22A4 SLC40A1 0.756 0.985 0.853 0.74 IL6 NFKB2 NR3C1 RGS2 SKA2 SLC40A1 0.756 0.985 0.853 0.716 IL6 PAX8 RGS2 SKA2 SLC22A4 SLC40A1 0.756 0.985 0.853 0.719 CCL27 FGFR2 FKBP5 RGS2 SLC40A1 STK11 0.819 0.898 0.853 0.823 HFE MMP13 SDK1 SKA2 SLC40A1 STK11 0.829 0.883 0.853 0.848 ABCA1 IL10 IL6 MUC1 NFKB2 STK11 0.791 0.927 0.853 0.819 CASP9 GH1 RGS2 SDK1 SLC40A1 STK11 0.804 0.914 0.853 0.812 CACNA1C CASP9 IL10 NR3C1 SLC40A1 STK11 0.804 0.914 0.853 0.812 EPO GCKR IL10 NFKB1 NLRP1 STK11 0.772 0.956 0.853 0.831 IL10 IL1B NR3C1 PAX8 SLC11A2 STK11 0.773 0.956 0.853 0.778 ABCA1 ADAMTS4 IL10 NFKB1 NLRP3 STK11 0.793 0.927 0.853 0.825 EPO IL10 MUC1 NFKB2 NLRP1 STK11 0.791 0.927 0.853 0.83 GCKR IL10 MUC1 NFKB1 NLRP1 STK11 0.791 0.927 0.853 0.831 IL10 MUC1 NFKB1 NLRP3 SMAD3 STK11 0.791 0.927 0.853 0.835 CASP9 NLRP1 RGS2 SDK1 SLC40A1 STK11 0.8 0.927 0.853 0.847 IL1B IL6 RGS2 SDK1 SLC40A1 TNF 0.771 0.957 0.853 0.813 ABCA1 IL6 MUC1 SDK1 STK11 TGFB1 0.824 0.885 0.853 0.839 CRHR1 IL10 KRT1 MUC1 NFKB1 STK11 0.825 0.885 0.853 0.856 FKBP5 HFE2 IL10 NFKB1 SLC6A3 STK11 0.827 0.885 0.853 0.85 CASP9 GH1 IL10 KRT1 NFKB1 STK11 0.802 0.914 0.853 0.833 HAMP IL10 NFKB1 PAX8 SLC6A3 STK11 0.802 0.914 0.853 0.849 CASP1 IL10 MMP13 NFKB1 NFKB2 STK11 0.887 0.828 0.853 0.845 CASP9 HAMP IL10 MMP13 SLC11A2 STK11 0.846 0.874 0.853 0.839 CASP3 IL6 NLRP1 RGS2 SLC40A1 SLC6A3 0.755 0.985 0.853 0.702 EDAR IL6 NLRP1 RGS2 SLC40A1 SLC6A3 0.755 0.985 0.853 0.705 FGFR2 IL6 NLRP1 RGS2 SLC40A1 SLC6A3 0.755 0.985 0.853 0.686 GCKR IL6 NLRP1 RGS2 SLC40A1 SLC6A3 0.755 0.985 0.853 0.682 HFE IL6 NLRP1 RGS2 SLC40A1 SLC6A3 0.755 0.985 0.853 0.744 HFE2 IL6 NLRP1 RGS2 SLC40A1 SLC6A3 0.755 0.985 0.853 0.702 CCL27 IL10 MUC1 NFKB2 SIRT1 STK11 0.803 0.914 0.853 0.813 FKBP5 IL10 MMP13 NFKB1 SLC40A1 STK11 0.848 0.871 0.853 0.858 ADAMTS4 FGFR2 RGS2 SLC40A1 STK11 VEGFA 0.783 0.942 0.853 0.803 IL18 MUC1 NFKB1 SKA2 SLC40A1 STK11 0.803 0.913 0.853 0.786 MUC1 PAX8 SDK1 SLC22A4 STK11 TGFB1 0.802 0.914 0.853 0.83 MUC1 SDK1 SLC11A2 SLC22A4 STK11 TGFB1 0.802 0.914 0.853 0.852 CASP9 CCL27 FKBP5 HFE IL10 STK11 0.82 0.902 0.853 0.809 CASP9 CCL27 HFE IL10 RGS2 STK11 0.82 0.902 0.853 0.801 CASP9 CCL27 IL10 PAX8 STK11 VEGFA 0.82 0.902 0.853 0.801 GH1 HAMP IL10 MUC1 NLRP1 STK11 0.816 0.898 0.853 0.826 HAMP IL10 MUC1 NLRP1 SLC22A4 STK11 0.816 0.898 0.853 0.835 HFE IL10 NFKB1 PAX8 SMAD3 STK11 0.841 0.87 0.853 0.84 CASP3 CASP9 IL10 NR3C1 PAX8 STK11 0.806 0.913 0.853 0.817 ADAMTS4 CASP9 NR3C1 SMAD3 STK11 TGFB1 0.805 0.913 0.853 0.798 CASP3 HFE IL10 NFKB1 NR3C1 STK11 0.805 0.913 0.853 0.795 CASP3 CASP9 IL10 IL6 NFKB1 STK11 0.828 0.885 0.853 0.858 CASP9 IL10 IL6 KRT1 NFKB1 STK11 0.827 0.886 0.853 0.844 CCL27 EPO HAMP RGS2 STK11 TGFB1 0.785 0.943 0.853 0.744 FKBP5 HAMP IL10 NFKB1 RGS2 STK11 0.845 0.87 0.852 0.848 RGS2 SDK1 SKA2 SLC40A1 TNF VEGFA 0.744 1 0.852 0.778 FKBP5 NFKB1 RGS2 SLC40A1 SMAD3 STK11 0.802 0.913 0.852 0.832 ABCA1 IL10 MUC1 NLRP1 STK11 TGFB1 0.851 0.87 0.852 0.839 IL10 IL1B IL6 MUC1 NLRP1 STK11 0.816 0.898 0.852 0.825 IL10 IL1B MUC1 NLRP1 SLC22A4 STK11 0.816 0.898 0.852 0.825 ABCA1 CACNA1C IL10 IL1B MUC1 STK11 0.794 0.928 0.852 0.785 ABCA1 CACNA1C IL10 MMP13 MUC1 STK11 0.794 0.928 0.852 0.822 ADAMTS4 CASP9 KRT83 RGS2 SLC40A1 STK11 0.814 0.9 0.852 0.827 IL10 RGS2 SDK1 SLC11A2 SLC40A1 STK11 0.805 0.914 0.852 0.838 MUC1 NFKB2 SIRT1 SLC11A2 STK11 VEGFA 0.791 0.927 0.852 0.792 CASP1 HAMP IL10 NFKB2 SLC11A2 STK11 0.792 0.931 0.852 0.824 CASP9 IL10 NFKB1 PPARG SIRT1 STK11 0.839 0.871 0.852 0.879 CD274 HFE IL10 NFKB1 SLC11A2 STK11 0.841 0.871 0.852 0.84 CASP9 CRHR1 IL10 IL6 NFKB1 STK11 0.835 0.886 0.852 0.853 CASP9 IL10 NFKB1 SKA2 SLC6A3 STK11 0.835 0.886 0.852 0.863 CASP9 CD274 HFE IL6 NFKB1 STK11 0.827 0.884 0.852 0.833 ABCA1 IL10 IL6 NFKB1 SLC11A2 STK11 0.806 0.914 0.852 0.834 ABCA1 GCKR MMP13 MUC1 SDK1 STK11 0.828 0.883 0.852 0.843 CRHR1 IL10 KRT83 MMP13 NFKB1 SIRT1 0.859 0.859 0.852 0.869 CCL27 IL1B MUC1 NLRP1 RGS2 STK11 0.836 0.881 0.852 0.827 CASP9 IL10 PAX8 SLC11A2 SLC22A4 STK11 0.822 0.902 0.852 0.835 CCL27 IL1A IL6 RGS2 SLC40A1 TNF 0.755 0.985 0.852 0.768 ADAMTS4 CD274 IL10 MUC1 NFKB1 STK11 0.791 0.926 0.852 0.851 CASP1 HFE2 IL10 MUC1 NFKB1 STK11 0.791 0.926 0.852 0.845 CASP1 IL10 IL18 MUC1 NFKB1 STK11 0.792 0.928 0.852 0.817 CD274 FGFR2 IL10 MUC1 NFKB1 STK11 0.791 0.926 0.852 0.84 CD274 GH1 IL10 MUC1 NFKB1 STK11 0.791 0.926 0.852 0.839 CD274 IL10 IL18 MUC1 NFKB1 STK11 0.792 0.928 0.852 0.823 CD274 IL10 KRT83 MUC1 NFKB1 STK11 0.791 0.926 0.852 0.834 CD274 IL10 MUC1 NFKB1 NLRP3 STK11 0.791 0.926 0.852 0.837 CRHR1 IL10 MUC1 NFKB1 STK11 TNF 0.791 0.927 0.852 0.841 GH1 IL10 KRT83 MUC1 NFKB1 STK11 0.791 0.926 0.852 0.826 HFE2 IL10 MUC1 NFKB1 NLRP3 STK11 0.791 0.926 0.852 0.843 IL10 MMP13 RGS2 SLC11A2 SLC22A4 STK11 0.865 0.857 0.852 0.85 CASP3 CD274 HFE IL10 NFKB1 STK11 0.841 0.87 0.852 0.849 HFE IL10 IL1B NFKB1 NFKB2 STK11 0.839 0.87 0.852 0.845 IL1A MUC1 NLRP1 RGS2 STK11 TGFB1 0.827 0.884 0.852 0.854 HFE2 MMP13 NLRP1 SDK1 SLC11A2 STK11 0.906 0.812 0.852 0.858 IL10 IL6 NFKB1 NR3C1 SIRT1 TGFB1 0.785 0.943 0.852 0.762 CASP1 HFE IL10 MUC1 NFKB1 STK11 0.825 0.883 0.852 0.858 CD274 IGF1 IL10 NFKB1 SLC6A3 STK11 0.827 0.885 0.852 0.851 EPO HFE NLRP1 SIRT1 SLC11A2 STK11 0.829 0.885 0.852 0.823 GCKR IL10 NFKB2 SLC11A2 STK11 VEGFA 0.831 0.888 0.852 0.85 HFE IL10 MUC1 NFKB1 PAX8 STK11 0.825 0.883 0.852 0.867 IL10 IL6 MUC1 NLRP1 SLC11A2 STK11 0.791 0.927 0.852 0.838 CACNA1C HAMP IL10 SLC22A4 SMAD3 STK11 0.804 0.914 0.852 0.804 CRHR1 IL1B IL6 NFKB2 RGS2 SLC40A1 0.783 0.942 0.852 0.826 ADAMTS4 CACNA1C IL10 NFKB1 PAX8 STK11 0.816 0.899 0.852 0.834 ADAMTS4 EDAR IL10 NFKB1 PAX8 STK11 0.816 0.899 0.852 0.814 ADAMTS4 HFE2 IL10 NFKB1 PAX8 STK11 0.818 0.899 0.852 0.833 CACNA1C EDAR IL10 NFKB1 PAX8 STK11 0.816 0.899 0.852 0.816 CASP1 EDAR IL10 NFKB1 PAX8 STK11 0.816 0.899 0.852 0.809 HFE2 IL10 NFKB1 PAX8 STK11 VEGFA 0.818 0.899 0.852 0.836 CASP9 EPO HFE IL6 SLC40A1 STK11 0.826 0.885 0.852 0.841 CACNA1C CCL27 HFE IL10 NFKB1 STK11 0.865 0.841 0.852 0.833 CCL27 IL10 NLRP1 SIRT1 SLC11A2 STK11 0.869 0.843 0.852 0.871 CCL27 SDK1 SIRT1 SLC11A2 SLC22A4 STK11 0.867 0.841 0.852 0.828 CD274 IL1B IL6 RGS2 SDK1 SLC40A1 0.771 0.957 0.852 0.797 CASP9 EPO KRT1 RGS2 SLC40A1 STK11 0.816 0.899 0.852 0.832 CASP9 HFE2 IGF1 RGS2 SLC40A1 STK11 0.816 0.899 0.852 0.827 CASP1 IL6 RGS2 SLC40A1 STK11 TGFB1 0.837 0.871 0.852 0.874 FKBP5 MUC1 NLRP1 SIRT1 SLC6A3 STK11 0.79 0.927 0.852 0.811 IL10 MUC1 NLRP1 RGS2 SLC11A2 STK11 0.814 0.898 0.852 0.843 ADAMTS4 GCKR IL10 NFKB1 PAX8 STK11 0.817 0.899 0.852 0.83 CASP1 FKBP5 IL10 KRT1 NFKB1 STK11 0.817 0.899 0.852 0.834 CASP1 GH1 IL10 NFKB1 PAX8 STK11 0.817 0.899 0.852 0.832 CASP1 IL10 KRT1 NFKB1 PAX8 STK11 0.817 0.899 0.852 0.828 CASP3 IL10 NFKB1 PAX8 STK11 VEGFA 0.817 0.899 0.852 0.841 CD274 IL10 NFKB1 NFKB2 PAX8 STK11 0.817 0.899 0.852 0.841 CRHR1 EPO IL10 IL1B NR3C1 SLC11A2 0.808 0.912 0.852 0.774 CCL27 FKBP5 IL1A SIRT1 SLC6A3 TNF 0.783 0.943 0.852 0.78 CASP1 IL6 RGS2 SDK1 SLC40A1 STK11 0.828 0.884 0.852 0.871 FKBP5 IL6 RGS2 SDK1 SLC40A1 STK11 0.828 0.884 0.852 0.861 IL6 RGS2 SDK1 SLC11A2 SLC40A1 STK11 0.828 0.884 0.852 0.865 CASP1 IL10 NFKB1 NLRP1 PAX8 STK11 0.807 0.912 0.852 0.812 NLRP1 SDK1 SIRT1 SLC11A2 SMAD3 STK11 0.867 0.84 0.852 0.83 IL10 MUC1 NFKB1 SKA2 STK11 TGFB1 0.831 0.885 0.852 0.876 GCKR HAMP IL10 STK11 TGFB1 TNF 0.822 0.902 0.852 0.834 CRHR1 IL1B IL6 RGS2 SLC22A4 SLC40A1 0.781 0.942 0.852 0.811 ADAMTS4 GH1 IL10 MUC1 NLRP1 STK11 0.815 0.898 0.852 0.825 ADAMTS4 IL10 IL6 MUC1 NLRP1 STK11 0.815 0.898 0.852 0.816 CACNA1C GH1 IL10 MUC1 NLRP1 STK11 0.815 0.898 0.852 0.82 GH1 IL10 MUC1 NLRP1 STK11 VEGFA 0.815 0.898 0.852 0.824 HAMP MMP13 NLRP1 SDK1 SLC11A2 STK11 0.907 0.811 0.852 0.857 HFE IL10 KRT1 MMP13 NFKB1 STK11 0.866 0.841 0.852 0.873 CASP9 GCKR HAMP IL10 SLC11A2 STK11 0.831 0.888 0.852 0.859 HFE IL10 NLRP1 SLC11A2 STK11 VEGFA 0.831 0.885 0.852 0.854 ABCA1 CCL27 RGS2 SIRT1 SLC11A2 SLC40A1 0.82 0.899 0.852 0.824 CCL27 GH1 RGS2 SIRT1 SLC11A2 SLC40A1 0.82 0.899 0.852 0.823 CCL27 RGS2 SIRT1 SLC11A2 SLC40A1 VEGFA 0.82 0.899 0.852 0.81 CCL27 IL1B IL6 RGS2 SIRT1 SLC40A1 0.828 0.883 0.852 0.86 CACNA1C CASP9 CD274 MMP13 SLC6A3 STK11 0.824 0.886 0.852 0.85 HFE MMP13 MUC1 NLRP1 STK11 VEGFA 0.827 0.884 0.852 0.851 NR3C1 SLC11A2 STK11 TGFB1 TNF VEGFA 0.807 0.913 0.852 0.786 IL10 NFKB1 NLRP3 SLC11A2 STK11 TGFB1 0.851 0.872 0.852 0.833 CCL27 FKBP5 MMP13 RGS2 SDK1 SLC40A1 0.769 0.971 0.852 0.821 CASP9 IL10 KRT1 NLRP1 SLC11A2 STK11 0.833 0.885 0.852 0.865 CACNA1C IL10 MUC1 NFKB2 NR3C1 STK11 0.793 0.927 0.852 0.808 CASP3 IL10 MMP13 NFKB1 NFKB2 STK11 0.884 0.828 0.852 0.849 CCL27 IL10 MMP13 NFKB1 NFKB2 STK11 0.884 0.828 0.852 0.851 FKBP5 IL10 MMP13 NFKB1 NFKB2 STK11 0.884 0.828 0.852 0.858 IL10 MMP13 NFKB1 NFKB2 NLRP1 STK11 0.884 0.828 0.852 0.844 ABCA1 HFE IL10 NFKB1 NR3C1 STK11 0.817 0.9 0.852 0.821 CRHR1 EDAR IL10 MMP13 NFKB1 SIRT1 0.868 0.842 0.852 0.849 HFE IL10 MMP13 NFKB1 NLRP3 STK11 0.867 0.841 0.852 0.875 HFE IL10 MMP13 NFKB1 STK11 VEGFA 0.867 0.841 0.852 0.877 CASP9 IL10 MMP13 MUC1 NLRP1 STK11 0.826 0.885 0.852 0.868 GH1 IL10 NLRP1 RGS2 SIRT1 TGFB1 0.835 0.885 0.852 0.798 IL10 MMP13 NFKB1 PPARG STK11 TGFB1 0.868 0.843 0.852 0.852 CCL27 MMP13 RGS2 SIRT1 SLC22A4 SLC40A1 0.831 0.883 0.852 0.848 CACNA1C IL10 SLC6A3 SMAD3 STK11 TGFB1 0.814 0.915 0.852 0.819 CD274 IL10 NFKB1 NLRP1 SLC6A3 STK11 0.808 0.914 0.852 0.841 ADAMTS4 FKBP5 IGF1 IL10 NFKB1 STK11 0.84 0.87 0.852 0.826 CASP1 FKBP5 IGF1 IL10 NFKB1 STK11 0.84 0.87 0.852 0.828 CASP1 HAMP IL10 MUC1 NR3C1 STK11 0.771 0.956 0.852 0.772 CASP9 GH1 IL10 NFKB1 NR3C1 STK11 0.805 0.914 0.852 0.798 CASP9 IL10 IL18 NFKB1 NR3C1 STK11 0.805 0.914 0.852 0.808 CASP9 IL10 NFKB2 NR3C1 PAX8 STK11 0.805 0.914 0.852 0.824 IL6 RGS2 SLC40A1 STK11 TGFB1 TNF 0.839 0.87 0.852 0.873 ABCA1 CASP3 IL10 MUC1 NFKB1 STK11 0.791 0.927 0.852 0.858 ABCA1 IL10 MUC1 NFKB1 NLRP3 STK11 0.79 0.926 0.852 0.835 CASP9 FKBP5 PAX8 RGS2 SLC40A1 STK11 0.813 0.9 0.852 0.832 CCL27 HFE IL10 SLC11A2 SLC22A4 STK11 0.804 0.913 0.852 0.811 CCL27 MUC1 RGS2 SDK1 SLC40A1 SLC6A3 0.776 0.956 0.852 0.796 CCL27 KRT83 NFKB2 RGS2 SIRT1 TGFB1 0.784 0.943 0.852 0.723 CACNA1C IL1B IL6 RGS2 SDK1 SLC40A1 0.77 0.956 0.852 0.813 CASP3 IL1B IL6 RGS2 SDK1 SLC40A1 0.77 0.956 0.852 0.817 CASP9 IL1B IL6 RGS2 SDK1 SLC40A1 0.77 0.956 0.852 0.809 CRHR1 IL1B IL6 RGS2 SDK1 SLC40A1 0.77 0.956 0.852 0.829 EDAR IL1B IL6 RGS2 SDK1 SLC40A1 0.77 0.956 0.852 0.799 EPO IL1B IL6 RGS2 SDK1 SLC40A1 0.77 0.956 0.852 0.815 FGFR2 IL1B IL6 RGS2 SDK1 SLC40A1 0.77 0.956 0.852 0.811 FKBP5 IL1B IL6 RGS2 SDK1 SLC40A1 0.77 0.956 0.852 0.82 GCKR IL1B IL6 RGS2 SDK1 SLC40A1 0.77 0.956 0.852 0.804 IL18 IL1B IL6 RGS2 SDK1 SLC40A1 0.77 0.956 0.852 0.811 IL1A IL1B IL6 RGS2 SDK1 SLC40A1 0.77 0.956 0.852 0.818 IL1B IL6 NFKB2 RGS2 SDK1 SLC40A1 0.77 0.956 0.852 0.804 IL1B IL6 RGS2 SDK1 SLC40A1 VEGFA 0.77 0.956 0.852 0.823 IL1B IL6 RGS2 SDK1 SLC40A1 SMAD3 0.77 0.956 0.852 0.801 CCL27 IL10 NFKB1 NLRP1 NLRP3 STK11 0.829 0.885 0.852 0.857 ADAMTS4 IGF1 IL10 MUC1 NFKB1 STK11 0.79 0.926 0.852 0.822 CASP9 IL10 NFKB1 PPARG SMAD3 STK11 0.803 0.914 0.852 0.841 HAMP IL10 RGS2 SDK1 SLC40A1 STK11 0.801 0.914 0.852 0.857 GCKR HAMP HFE IL10 STK11 TGFB1 0.854 0.874 0.852 0.821 IL10 IL1B MUC1 NFKB1 NFKB2 STK11 0.828 0.885 0.852 0.843 ADAMTS4 RGS2 SKA2 SLC40A1 STK11 TGFB1 0.84 0.869 0.852 0.851 CCL27 HFE IL6 MMP13 NFKB1 STK11 0.865 0.851 0.852 0.874 CCL27 FKBP5 HFE RGS2 SDK1 SLC40A1 0.757 0.985 0.852 0.789 CCL27 HFE NLRP3 RGS2 SDK1 SLC40A1 0.757 0.985 0.852 0.8 CCL27 HFE RGS2 SDK1 SLC40A1 SMAD3 0.757 0.985 0.852 0.809 CASP9 HFE IL10 KRT1 NFKB1 STK11 0.835 0.872 0.852 0.829 HFE NLRP1 SIRT1 SLC11A2 SLC22A4 STK11 0.838 0.87 0.852 0.822 CASP3 CASP9 EPO IL10 NR3C1 STK11 0.809 0.915 0.852 0.827 HFE IL6 NR3C1 SLC22A4 STK11 TGFB1 0.805 0.912 0.852 0.823 CASP3 IL10 NFKB1 NLRP3 PPARG STK11 0.803 0.914 0.852 0.8 CASP9 IL10 IL6 NFKB1 NLRP1 STK11 0.802 0.914 0.852 0.867 CASP9 IL10 IL6 NFKB1 SLC22A4 STK11 0.802 0.914 0.852 0.86 CASP9 IL10 NFKB1 NLRP3 STK11 TNF 0.804 0.914 0.852 0.825 HAMP IL10 IL6 NFKB1 SLC6A3 STK11 0.803 0.914 0.852 0.856 HAMP IL10 KRT83 NLRP1 SLC11A2 STK11 0.801 0.913 0.852 0.842 CASP1 HAMP IL10 RGS2 SLC40A1 STK11 0.843 0.872 0.852 0.88 EDAR IL10 MUC1 NFKB2 NR3C1 STK11 0.771 0.956 0.852 0.813 FGFR2 GCKR IL10 NFKB1 PAX8 STK11 0.806 0.912 0.852 0.828 CCL27 NLRP1 RGS2 SIRT1 SLC40A1 TGFB1 0.804 0.913 0.852 0.849 ADAMTS4 IL10 NFKB2 SDK1 SLC11A2 STK11 0.836 0.872 0.852 0.831 IL6 NLRP1 RGS2 SLC40A1 STK11 TGFB1 0.835 0.871 0.852 0.888 IL6 RGS2 SLC40A1 SLC6A3 STK11 TGFB1 0.835 0.871 0.852 0.878 IL1A MUC1 NLRP1 RGS2 SMAD3 STK11 0.828 0.883 0.852 0.836 IGF1 IL10 MUC1 NFKB2 STK11 VEGFA 0.791 0.927 0.852 0.804 IL18 MUC1 NR3C1 SLC40A1 STK11 TNF 0.806 0.914 0.852 0.766 ADAMTS4 HFE IL1B MMP13 RGS2 SLC40A1 0.771 0.956 0.852 0.84 HAMP HFE IL1B MMP13 RGS2 SLC40A1 0.771 0.956 0.852 0.848 HFE IL1B MMP13 RGS2 SLC22A4 SLC40A1 0.771 0.956 0.852 0.839 ABCA1 ADAMTS4 CASP9 MMP13 MUC1 STK11 0.8 0.914 0.852 0.803 ABCA1 CASP9 MMP13 MUC1 PAX8 STK11 0.8 0.914 0.852 0.803 CASP1 IL10 MUC1 NFKB1 STK11 TGFB1 0.791 0.928 0.852 0.858 CASP9 GCKR HFE IL6 STK11 TGFB1 0.804 0.913 0.852 0.813 FKBP5 HAMP IL10 IL1A NFKB1 STK11 0.802 0.913 0.852 0.829 CACNA1C CCL27 HAMP IL10 KRT1 NLRP1 0.768 0.957 0.852 0.756 CASP9 IL10 IL6 MMP13 NLRP1 STK11 0.869 0.857 0.852 0.872 CASP9 CCL27 FKBP5 IL10 IL6 STK11 0.82 0.902 0.852 0.811 IL10 MUC1 NFKB2 NLRP1 SLC11A2 STK11 0.814 0.896 0.852 0.826 CACNA1C CRHR1 IL10 MMP13 NFKB1 SIRT1 0.858 0.859 0.852 0.869 CRHR1 IL10 IL1B MMP13 NFKB1 SIRT1 0.859 0.859 0.852 0.854 CASP9 EPO IL10 NFKB1 STK11 TGFB1 0.839 0.872 0.852 0.863 FKBP5 KRT1 NLRP1 SIRT1 SLC11A2 STK11 0.839 0.871 0.852 0.846 HFE IL10 NFKB1 SLC11A2 STK11 TNF 0.837 0.871 0.852 0.82 IL10 MMP13 NFKB1 PPARG SLC6A3 STK11 0.836 0.871 0.852 0.854 IL10 MMP13 NLRP1 PAX8 SMAD3 STK11 0.834 0.886 0.852 0.865 IL10 MUC1 NFKB2 PAX8 SDK1 STK11 0.823 0.884 0.852 0.842 CACNA1C HAMP IL10 SLC11A2 SLC22A4 STK11 0.803 0.915 0.852 0.846 HAMP IL10 NLRP3 SLC11A2 SLC22A4 STK11 0.804 0.915 0.852 0.847 HAMP IL10 SLC11A2 SLC22A4 STK11 TGFB1 0.803 0.915 0.852 0.853 CD274 HFE2 IL10 NFKB1 PAX8 STK11 0.815 0.898 0.852 0.847 FKBP5 GCKR HFE2 IL10 NFKB1 STK11 0.815 0.898 0.852 0.842 HFE2 IL10 NFKB1 NFKB2 PAX8 STK11 0.815 0.898 0.852 0.835 IL10 NFKB1 PAX8 SMAD3 STK11 VEGFA 0.815 0.898 0.852 0.843 GCKR IL10 MUC1 NFKB2 SDK1 STK11 0.825 0.884 0.852 0.845 CACNA1C CD274 HAMP IL10 NLRP1 STK11 0.768 0.957 0.852 0.796 EPO GH1 HAMP IL10 NLRP1 STK11 0.768 0.957 0.852 0.791 GH1 HAMP IL10 NLRP1 SKA2 STK11 0.768 0.957 0.852 0.785 CACNA1C IL10 IL1A NFKB1 STK11 VEGFA 0.802 0.914 0.852 0.837 CASP1 IL10 NFKB1 PAX8 SLC6A3 STK11 0.802 0.914 0.852 0.851 FKBP5 IL10 KRT1 NFKB1 SLC40A1 STK11 0.802 0.914 0.852 0.862 HAMP IL10 NFKB1 NLRP3 STK11 TNF 0.804 0.914 0.852 0.84 CD274 IL10 NFKB1 SLC11A2 STK11 TGFB1 0.85 0.874 0.852 0.858 ADAMTS4 HAMP IL10 NFKB1 SLC11A2 STK11 0.839 0.871 0.852 0.837 CASP9 HFE2 IL10 NFKB1 PAX8 STK11 0.839 0.871 0.852 0.844 CCL27 RGS2 SKA2 SLC40A1 STK11 TGFB1 0.835 0.87 0.852 0.855 IL6 NFKB1 RGS2 SLC40A1 STK11 TGFB1 0.837 0.871 0.852 0.872 EPO IL10 IL6 MMP13 NFKB1 STK11 0.856 0.856 0.852 0.858 GCKR IL1B MMP13 RGS2 SLC40A1 SLC6A3 0.802 0.912 0.852 0.86 CACNA1C MUC1 NLRP1 NR3C1 STK11 TNF 0.808 0.912 0.852 0.786 FGFR2 MUC1 NLRP1 NR3C1 STK11 TNF 0.808 0.912 0.852 0.791 GH1 MUC1 NLRP1 NR3C1 STK11 TNF 0.808 0.912 0.852 0.791 HFE2 MUC1 NLRP1 NR3C1 STK11 TNF 0.808 0.912 0.852 0.788 MUC1 NLRP1 NR3C1 SMAD3 STK11 TNF 0.808 0.912 0.852 0.796 HAMP IL10 MUC1 SLC22A4 SMAD3 STK11 0.824 0.885 0.852 0.828 CACNA1C CD274 IL10 NFKB1 PAX8 STK11 0.816 0.899 0.852 0.851 CASP1 IGF1 IL10 NFKB1 PAX8 STK11 0.816 0.899 0.852 0.833 CD274 IL10 NFKB1 PAX8 SLC40A1 STK11 0.816 0.899 0.852 0.845 EDAR FGFR2 HAMP IL10 STK11 TGFB1 0.819 0.902 0.852 0.797 EPO GH1 IL10 NFKB1 SLC22A4 STK11 0.816 0.899 0.852 0.821 EPO IL10 NFKB1 NFKB2 PAX8 STK11 0.816 0.899 0.852 0.85 EPO IL10 NFKB1 PAX8 STK11 VEGFA 0.816 0.899 0.852 0.846 CASP9 KRT1 MMP13 NLRP1 SLC22A4 STK11 0.868 0.842 0.852 0.867 EDAR FKBP5 IL10 MMP13 NFKB1 SIRT1 0.87 0.842 0.852 0.844 CASP1 NLRP1 SDK1 SIRT1 SLC40A1 TNF 0.769 0.957 0.852 0.784 IL10 NLRP1 PPARG SIRT1 SLC11A2 STK11 0.829 0.885 0.852 0.855 FKBP5 HFE2 NLRP1 SIRT1 SLC11A2 STK11 0.837 0.871 0.852 0.833 FKBP5 IGF1 IL10 KRT83 NFKB1 STK11 0.838 0.869 0.852 0.821 CCL27 GH1 MMP13 RGS2 SLC40A1 STK11 0.84 0.869 0.852 0.856 CASP3 HFE IL10 NFKB1 STK11 VEGFA 0.839 0.869 0.852 0.856 GCKR HFE IL10 NFKB1 STK11 VEGFA 0.839 0.869 0.852 0.851 IL10 MMP13 NFKB1 SLC6A3 STK11 VEGFA 0.84 0.87 0.852 0.863 HFE IL1B NLRP1 SIRT1 SLC11A2 STK11 0.804 0.913 0.852 0.803 HFE IL10 MUC1 NFKB2 NLRP1 STK11 0.814 0.898 0.852 0.835 CCL27 FGFR2 IL10 RGS2 SLC40A1 STK11 0.813 0.899 0.852 0.847 CASP3 IL10 MUC1 NFKB1 SKA2 STK11 0.828 0.884 0.852 0.858 CASP9 EPO NLRP1 SIRT1 SLC11A2 STK11 0.826 0.885 0.852 0.835 CASP9 MMP13 MUC1 NLRP1 SLC22A4 STK11 0.824 0.885 0.852 0.878 CACNA1C CASP9 RGS2 SLC40A1 SLC6A3 STK11 0.792 0.928 0.852 0.821 EDAR GCKR MUC1 NLRP1 SLC40A1 STK11 0.771 0.956 0.852 0.766 MUC1 NLRP1 NR3C1 SLC22A4 SLC40A1 STK11 0.771 0.956 0.852 0.753 CASP9 HFE2 RGS2 SLC40A1 STK11 TGFB1 0.813 0.899 0.852 0.851 CCL27 IL10 RGS2 SIRT1 SLC11A2 SLC40A1 0.819 0.899 0.852 0.816 CASP9 FGFR2 HFE2 RGS2 SLC40A1 STK11 0.827 0.885 0.852 0.823 EDAR FKBP5 NLRP1 SIRT1 SLC11A2 STK11 0.841 0.871 0.852 0.825 HFE IL10 IL18 NFKB1 STK11 VEGFA 0.836 0.87 0.852 0.832 CCL27 IL18 SDK1 SLC11A2 SLC40A1 STK11 0.797 0.928 0.852 0.815 CACNA1C CASP3 CASP9 IL10 NR3C1 STK11 0.807 0.914 0.852 0.824 FKBP5 RGS2 SLC22A4 SLC40A1 SMAD3 STK11 0.813 0.898 0.852 0.842 FGFR2 IL10 MMP13 NFKB1 RGS2 STK11 0.879 0.827 0.852 0.874 CASP9 HFE MMP13 SLC22A4 SLC6A3 STK11 0.834 0.871 0.852 0.858 CASP9 IGF1 RGS2 SLC11A2 SLC40A1 STK11 0.78 0.942 0.852 0.816 FKBP5 IL10 NFKB1 NLRP3 SLC22A4 STK11 0.839 0.87 0.852 0.85 FKBP5 GCKR HFE IL10 NFKB1 STK11 0.84 0.869 0.852 0.861 HFE IL6 KRT83 NLRP1 SLC11A2 STK11 0.828 0.884 0.852 0.835 MMP13 NLRP1 SIRT1 SLC11A2 SLC22A4 STK11 0.867 0.842 0.852 0.876 CACNA1C IL10 MMP13 NFKB1 SLC40A1 STK11 0.837 0.871 0.852 0.84 HAMP HFE IL10 IL1B NFKB1 STK11 0.837 0.871 0.852 0.851 IL10 KRT1 NFKB1 SKA2 SMAD3 STK11 0.841 0.871 0.852 0.819 IL10 SLC11A2 SLC40A1 STK11 TNF VEGFA 0.816 0.899 0.852 0.855 CCL27 GCKR HFE MUC1 NR3C1 SLC40A1 0.777 0.955 0.852 0.753 HFE MUC1 NR3C1 PAX8 SLC40A1 STK11 0.784 0.942 0.852 0.768 CCL27 HFE MUC1 NLRP1 SDK1 STK11 0.835 0.87 0.852 0.857 CACNA1C IL10 MMP13 NFKB1 SLC6A3 STK11 0.838 0.871 0.852 0.868 CASP9 EPO FGFR2 IL10 NFKB1 STK11 0.816 0.9 0.852 0.851 CASP3 GH1 IL10 MUC1 NFKB2 STK11 0.773 0.957 0.852 0.813 EDAR IL10 KRT83 NFKB1 PAX8 STK11 0.814 0.898 0.852 0.807 ABCA1 MMP13 MUC1 NLRP1 SLC22A4 STK11 0.826 0.884 0.852 0.858 EDAR HFE IL6 MMP13 NFKB1 STK11 0.869 0.838 0.852 0.862 ADAMTS4 IL10 NFKB1 PAX8 SLC11A2 STK11 0.84 0.87 0.852 0.834 CCL27 FGFR2 IL10 NFKB1 SLC11A2 STK11 0.84 0.87 0.852 0.844 IL10 IL1B MUC1 NLRP1 STK11 TNF 0.829 0.884 0.852 0.817 CASP3 HAMP IL10 SMAD3 STK11 TGFB1 0.816 0.9 0.852 0.801 ABCA1 IL1B IL6 RGS2 SDK1 SLC40A1 0.77 0.957 0.852 0.801 CASP3 IL10 IL1A MUC1 NFKB1 STK11 0.802 0.913 0.852 0.86 FKBP5 HFE IL10 NFKB1 STK11 TNF 0.842 0.87 0.852 0.86 GCKR HFE IL10 NFKB1 PAX8 STK11 0.841 0.869 0.852 0.847 FGFR2 IL10 IL18 MMP13 NFKB1 STK11 0.854 0.857 0.852 0.846 CASP9 IL10 MUC1 NFKB1 SIRT1 STK11 0.84 0.872 0.852 0.874 CD274 EDAR HFE IL10 NFKB1 STK11 0.837 0.87 0.852 0.824 CRHR1 HFE IL10 NFKB1 NFKB2 STK11 0.84 0.87 0.852 0.844 FKBP5 NLRP1 SIRT1 SLC11A2 SLC22A4 STK11 0.839 0.871 0.852 0.837 CCL27 IL1B MUC1 RGS2 SDK1 SLC40A1 0.791 0.927 0.852 0.836 IL10 IL6 MUC1 NFKB1 SMAD3 STK11 0.8 0.913 0.852 0.84 CASP9 HFE IL18 MMP13 SLC40A1 STK11 0.835 0.871 0.852 0.829 ADAMTS4 CASP3 CCL27 RGS2 SIRT1 SLC40A1 0.827 0.884 0.852 0.805 CASP3 CASP9 IL10 NFKB1 STK11 TNF 0.801 0.914 0.852 0.825 CASP3 HFE MMP13 NFKB2 NR3C1 STK11 0.832 0.883 0.852 0.831 IL10 KRT1 MUC1 NFKB1 SMAD3 STK11 0.8 0.913 0.852 0.838 IL10 RGS2 SKA2 SLC40A1 SLC6A3 STK11 0.8 0.913 0.852 0.875 CASP9 MUC1 NFKB1 NR3C1 RGS2 STK11 0.804 0.912 0.852 0.737 IL10 NFKB1 NR3C1 PAX8 STK11 VEGFA 0.792 0.928 0.852 0.811 CACNA1C CCL27 FGFR2 HAMP IL10 NLRP1 0.768 0.957 0.852 0.74 CCL27 FGFR2 HAMP IL10 NLRP1 SKA2 0.768 0.957 0.852 0.763 GCKR HAMP IL10 IL1A NFKB1 STK11 0.8 0.914 0.852 0.83 CCL27 NFKB2 RGS2 SIRT1 SLC22A4 TGFB1 0.79 0.927 0.852 0.789 CCL27 HFE MUC1 RGS2 SLC40A1 SLC6A3 0.768 0.956 0.852 0.812 ABCA1 CASP9 IL10 IL6 NFKB1 STK11 0.8 0.914 0.852 0.861 EPO IL10 RGS2 SLC40A1 SLC6A3 STK11 0.802 0.914 0.852 0.849 GH1 HAMP IL10 NFKB1 SLC6A3 STK11 0.799 0.914 0.852 0.851 HFE2 IL10 RGS2 SLC40A1 STK11 VEGFA 0.802 0.914 0.852 0.827 FKBP5 RGS2 SKA2 SLC40A1 STK11 VEGFA 0.806 0.91 0.852 0.842 CASP9 NLRP1 SIRT1 SLC11A2 STK11 VEGFA 0.828 0.884 0.852 0.865 FKBP5 MMP13 RGS2 SLC40A1 SLC6A3 STK11 0.837 0.869 0.852 0.88 IL18 MUC1 NFKB2 NLRP1 SDK1 STK11 0.837 0.883 0.852 0.834 FKBP5 HFE MMP13 NLRP1 SLC11A2 STK11 0.869 0.84 0.852 0.862 ABCA1 CCL27 NR3C1 SIRT1 SLC11A2 SLC40A1 0.782 0.941 0.852 0.764 CCL27 GCKR NR3C1 SIRT1 SLC11A2 SLC40A1 0.782 0.941 0.852 0.77 CCL27 GH1 HAMP RGS2 STK11 TGFB1 0.781 0.942 0.852 0.743 CCL27 KRT83 NR3C1 SIRT1 SLC11A2 SLC40A1 0.782 0.941 0.852 0.765 CCL27 NFKB2 NR3C1 SIRT1 SLC11A2 SLC40A1 0.782 0.941 0.852 0.776 GH1 NR3C1 SIRT1 SLC11A2 SLC40A1 SMAD3 0.782 0.941 0.852 0.681 ADAMTS4 MMP13 MUC1 NLRP1 SKA2 STK11 0.837 0.871 0.852 0.844 HFE IL6 MMP13 SDK1 SLC40A1 STK11 0.84 0.869 0.852 0.875 EPO GH1 IL10 NFKB1 PAX8 STK11 0.816 0.898 0.852 0.846 CASP9 HAMP IL10 KRT1 NFKB1 STK11 0.799 0.914 0.852 0.833 ADAMTS4 MMP13 NLRP1 NLRP3 SLC11A2 STK11 0.867 0.843 0.852 0.86 IL10 NLRP1 NR3C1 SLC11A2 SMAD3 STK11 0.8 0.912 0.852 0.832 CASP9 GH1 RGS2 SLC40A1 SLC6A3 STK11 0.779 0.942 0.851 0.828 CASP9 IL18 SLC11A2 SLC40A1 STK11 VEGFA 0.782 0.943 0.851 0.804 CASP9 RGS2 SLC11A2 SLC40A1 SLC6A3 STK11 0.779 0.942 0.851 0.835 CASP9 HFE IL6 NFKB1 SLC22A4 STK11 0.803 0.913 0.851 0.85 HFE MUC1 NLRP1 SDK1 SLC40A1 STK11 0.806 0.913 0.851 0.857 EDAR NLRP3 RGS2 SDK1 SKA2 SLC40A1 0.752 0.986 0.851 0.774 FKBP5 NFKB2 RGS2 SDK1 SKA2 SLC40A1 0.752 0.986 0.851 0.775 CASP3 IL10 MUC1 NFKB1 PAX8 STK11 0.801 0.913 0.851 0.853 FKBP5 HAMP IL10 NFKB1 NR3C1 STK11 0.812 0.899 0.851 0.822 HAMP IL10 KRT83 NFKB1 PAX8 STK11 0.812 0.899 0.851 0.832 HAMP IL10 NFKB1 NR3C1 PAX8 STK11 0.812 0.899 0.851 0.812 ABCA1 CASP9 MMP13 RGS2 SLC40A1 STK11 0.815 0.899 0.851 0.856 ADAMTS4 CASP9 MMP13 RGS2 SLC40A1 STK11 0.815 0.899 0.851 0.861 CASP9 GH1 MMP13 RGS2 SLC40A1 STK11 0.815 0.899 0.851 0.859 CASP9 HAMP MMP13 RGS2 SLC40A1 STK11 0.815 0.899 0.851 0.844 CCL27 RGS2 SIRT1 SLC22A4 SMAD3 TGFB1 0.79 0.926 0.851 0.782 IL10 IL6 MMP13 NFKB1 SIRT1 STK11 0.869 0.842 0.851 0.87 CASP9 GCKR IL1B MMP13 RGS2 SLC40A1 0.801 0.912 0.851 0.86 CASP9 GH1 IL6 RGS2 SLC40A1 STK11 0.819 0.898 0.851 0.84 CACNA1C CASP9 MMP13 NFKB1 SLC6A3 STK11 0.834 0.872 0.851 0.845 CASP9 HFE HFE2 MMP13 SLC40A1 STK11 0.852 0.857 0.851 0.842 CASP9 HFE IGF1 IL10 NFKB1 STK11 0.837 0.871 0.851 0.843 CASP9 HFE IL10 NFKB1 SKA2 STK11 0.835 0.871 0.851 0.84 GCKR IL10 NFKB1 PAX8 STK11 TGFB1 0.814 0.9 0.851 0.853 ADAMTS4 HAMP IL10 MMP13 NFKB1 STK11 0.852 0.856 0.851 0.849 CCL27 IL1B MUC1 NLRP1 STK11 TGFB1 0.803 0.913 0.851 0.809 HFE2 IL6 MUC1 NFKB1 NLRP1 STK11 0.805 0.912 0.851 0.823 HFE NLRP1 RGS2 SIRT1 STK11 TNF 0.826 0.883 0.851 0.81 HAMP IL10 MUC1 NLRP1 SKA2 STK11 0.825 0.884 0.851 0.833 CASP9 HFE IL10 NFKB1 SLC6A3 STK11 0.824 0.886 0.851 0.881 ABCA1 CASP9 IL10 KRT1 MUC1 STK11 0.802 0.915 0.851 0.802 CACNA1C IL10 MUC1 NFKB2 SIRT1 STK11 0.801 0.913 0.851 0.806 IL10 NFKB1 NLRP3 PAX8 SLC6A3 STK11 0.801 0.914 0.851 0.84 CASP1 GH1 KRT1 NLRP1 SDK1 SLC40A1 0.75 0.986 0.851 0.761 CACNA1C MMP13 NLRP1 RGS2 SLC11A2 STK11 0.887 0.827 0.851 0.877 CASP9 IL10 SDK1 SLC11A2 SLC40A1 STK11 0.803 0.915 0.851 0.837 CASP9 CRHR1 IL1B IL6 RGS2 SLC40A1 0.779 0.942 0.851 0.807 CRHR1 EDAR IL1B IL6 RGS2 SLC40A1 0.779 0.942 0.851 0.807 CRHR1 GCKR IL1B IL6 RGS2 SLC40A1 0.779 0.942 0.851 0.816 CRHR1 HFE2 IL1B IL6 RGS2 SLC40A1 0.779 0.942 0.851 0.822 CRHR1 IL18 IL1B IL6 RGS2 SLC40A1 0.779 0.942 0.851 0.805 CRHR1 IL1A IL1B IL6 RGS2 SLC40A1 0.779 0.942 0.851 0.809 CRHR1 IL1B IL6 KRT83 RGS2 SLC40A1 0.779 0.942 0.851 0.814 CRHR1 IL1B IL6 NFKB1 RGS2 SLC40A1 0.779 0.942 0.851 0.809 CRHR1 IL1B IL6 RGS2 SLC40A1 SMAD3 0.779 0.942 0.851 0.819 CRHR1 IL1B IL6 RGS2 SLC40A1 VEGFA 0.779 0.942 0.851 0.807 CCL27 CRHR1 HFE MMP13 SDK1 SLC40A1 0.778 0.942 0.851 0.859 EPO IL10 MMP13 NFKB1 STK11 TNF 0.836 0.871 0.851 0.854 IGF1 IL6 RGS2 SLC40A1 STK11 TGFB1 0.836 0.871 0.851 0.859 CD274 IL10 IL1A MUC1 NFKB2 STK11 0.802 0.913 0.851 0.846 HFE IL6 MMP13 MUC1 SLC40A1 STK11 0.839 0.87 0.851 0.865 CACNA1C CASP9 CCL27 IL18 MMP13 STK11 0.868 0.843 0.851 0.809 CASP9 MMP13 NFKB2 PAX8 STK11 VEGFA 0.867 0.845 0.851 0.799 CCL27 HAMP IL10 STK11 TGFB1 TNF 0.817 0.902 0.851 0.823 FGFR2 IL10 NFKB1 NLRP3 PAX8 STK11 0.814 0.899 0.851 0.827 IL10 NFKB2 SDK1 SIRT1 SLC11A2 STK11 0.817 0.902 0.851 0.821 CD274 CRHR1 FKBP5 IL10 NFKB1 STK11 0.81 0.899 0.851 0.839 ABCA1 ADAMTS4 CASP9 HFE MMP13 STK11 0.824 0.884 0.851 0.831 ABCA1 CASP9 HFE MMP13 SLC11A2 STK11 0.824 0.884 0.851 0.836 CD274 IL10 NFKB1 SLC11A2 SLC6A3 STK11 0.825 0.886 0.851 0.847 GH1 MUC1 NR3C1 SLC40A1 STK11 TNF 0.801 0.912 0.851 0.761 KRT83 MUC1 NR3C1 SLC40A1 STK11 TNF 0.801 0.912 0.851 0.756 MUC1 NR3C1 PPARG SLC40A1 STK11 TNF 0.801 0.912 0.851 0.756 KRT83 NLRP1 PPARG SIRT1 SLC11A2 STK11 0.825 0.884 0.851 0.848 FKBP5 MMP13 RGS2 SLC40A1 STK11 VEGFA 0.838 0.869 0.851 0.87 IL10 IL1A MUC1 NFKB1 STK11 VEGFA 0.803 0.913 0.851 0.861 EPO HAMP IL10 SLC22A4 SMAD3 STK11 0.801 0.913 0.851 0.823 CASP9 IL10 NFKB1 NFKB2 SKA2 STK11 0.838 0.872 0.851 0.839 CCL27 KRT83 MUC1 NLRP1 RGS2 STK11 0.845 0.867 0.851 0.843 CRHR1 IL18 IL1A MUC1 NLRP1 STK11 0.789 0.927 0.851 0.789 EPO FKBP5 IL10 NFKB1 SLC22A4 STK11 0.811 0.899 0.851 0.844 ADAMTS4 MMP13 MUC1 NLRP1 SDK1 STK11 0.871 0.841 0.851 0.872 CASP9 PAX8 RGS2 SLC40A1 STK11 TGFB1 0.826 0.885 0.851 0.835 FKBP5 HAMP IL10 RGS2 STK11 TGFB1 0.82 0.902 0.851 0.796 IL18 MMP13 MUC1 NLRP1 SLC6A3 STK11 0.803 0.913 0.851 0.834 FKBP5 MMP13 NFKB1 NLRP1 RGS2 STK11 0.89 0.824 0.851 0.846 ABCA1 CASP9 RGS2 SLC40A1 STK11 VEGFA 0.79 0.928 0.851 0.83 CASP9 CCL27 RGS2 SLC40A1 STK11 TNF 0.791 0.928 0.851 0.833 CASP9 EPO GCKR RGS2 SLC40A1 STK11 0.79 0.928 0.851 0.829 CASP9 FGFR2 PPARG RGS2 SLC40A1 STK11 0.791 0.928 0.851 0.802 CASP9 NFKB1 RGS2 SLC40A1 STK11 VEGFA 0.79 0.928 0.851 0.82 CASP9 RGS2 SLC40A1 SLC6A3 STK11 VEGFA 0.79 0.928 0.851 0.835 HAMP IL10 NLRP1 RGS2 SMAD3 STK11 0.825 0.883 0.851 0.836 HAMP IL10 RGS2 SIRT1 SLC22A4 STK11 0.83 0.885 0.851 0.816 IL10 NR3C1 SIRT1 STK11 TGFB1 TNF 0.806 0.914 0.851 0.823 CASP9 HAMP HFE IL10 PPARG STK11 0.82 0.903 0.851 0.833 GCKR IL10 KRT83 NFKB1 STK11 TGFB1 0.816 0.902 0.851 0.846 GCKR GH1 IL10 MMP13 NFKB1 STK11 0.848 0.857 0.851 0.858 IL10 MMP13 NFKB1 NFKB2 SKA2 STK11 0.848 0.857 0.851 0.854 ADAMTS4 HFE2 IL10 NFKB2 SLC11A2 STK11 0.805 0.915 0.851 0.825 CCL27 FGFR2 MUC1 NLRP1 SDK1 STK11 0.845 0.869 0.851 0.848 CCL27 KRT1 MUC1 NLRP1 SDK1 STK11 0.845 0.869 0.851 0.852 CCL27 MUC1 NFKB2 NLRP1 SDK1 STK11 0.845 0.869 0.851 0.852 CCL27 MUC1 NLRP1 PPARG SDK1 STK11 0.845 0.869 0.851 0.818 CD274 FGFR2 RGS2 SLC40A1 STK11 VEGFA 0.791 0.928 0.851 0.804 ADAMTS4 CASP1 IL10 NFKB1 SLC40A1 STK11 0.838 0.872 0.851 0.849 CASP1 IL10 NFKB1 PAX8 SLC40A1 STK11 0.838 0.872 0.851 0.856 CASP9 HFE IL10 NFKB1 STK11 TNF 0.839 0.872 0.851 0.829 IL10 IL1A NFKB1 NFKB2 SLC11A2 STK11 0.84 0.871 0.851 0.813 CACNA1C MMP13 RGS2 SLC40A1 STK11 TGFB1 0.84 0.871 0.851 0.885 CCL27 IL1B RGS2 SIRT1 SLC11A2 SLC40A1 0.839 0.87 0.851 0.841 EPO FGFR2 IL10 MMP13 NFKB1 STK11 0.838 0.871 0.851 0.844 CD274 MUC1 NFKB1 NR3C1 SKA2 STK11 0.782 0.941 0.851 0.746 FGFR2 HFE MUC1 NR3C1 SLC40A1 STK11 0.783 0.941 0.851 0.762 FKBP5 MUC1 NFKB2 NR3C1 SLC40A1 STK11 0.782 0.941 0.851 0.745 HAMP MUC1 NR3C1 SLC40A1 STK11 TGFB1 0.782 0.941 0.851 0.747 HFE IL1B IL6 RGS2 SIRT1 SLC40A1 0.782 0.942 0.851 0.867 HFE MUC1 NFKB1 NR3C1 PAX8 STK11 0.782 0.941 0.851 0.75 HFE MUC1 NFKB1 NR3C1 SLC40A1 STK11 0.783 0.941 0.851 0.772 IGF1 MUC1 NR3C1 PAX8 SLC40A1 STK11 0.783 0.941 0.851 0.75 IL18 MUC1 NFKB2 NR3C1 STK11 TGFB1 0.782 0.941 0.851 0.763 MUC1 NFKB2 NR3C1 SKA2 STK11 TGFB1 0.782 0.941 0.851 0.774 MUC1 NFKB2 NR3C1 SLC40A1 STK11 TGFB1 0.782 0.941 0.851 0.761 MUC1 NR3C1 PAX8 SLC40A1 STK11 TGFB1 0.782 0.941 0.851 0.763 CRHR1 IL10 MUC1 NFKB1 NFKB2 STK11 0.825 0.884 0.851 0.847 CASP9 HFE2 MMP13 SLC11A2 STK11 VEGFA 0.834 0.886 0.851 0.829 FKBP5 MMP13 MUC1 NLRP1 RGS2 STK11 0.876 0.838 0.851 0.874 CRHR1 HFE MUC1 RGS2 SDK1 SLC40A1 0.751 0.986 0.851 0.754 ABCA1 CASP9 GH1 RGS2 SLC40A1 STK11 0.79 0.928 0.851 0.82 ABCA1 CD274 IL10 MUC1 NLRP3 STK11 0.769 0.956 0.851 0.778 ADAMTS4 IL10 MMP13 NFKB1 NLRP1 STK11 0.854 0.856 0.851 0.853 HFE2 MMP13 NLRP1 SLC11A2 SLC22A4 STK11 0.855 0.855 0.851 0.878 CCL27 MMP13 NLRP1 RGS2 SIRT1 SMAD3 0.868 0.84 0.851 0.853 CCL27 IL6 NFKB1 RGS2 SIRT1 SLC40A1 0.807 0.912 0.851 0.827 CASP9 IL10 MUC1 NFKB2 SIRT1 STK11 0.804 0.915 0.851 0.833 ABCA1 MMP13 NLRP1 RGS2 SDK1 STK11 0.879 0.84 0.851 0.883 CASP9 HAMP IL10 SLC11A2 SLC40A1 STK11 0.802 0.914 0.851 0.877 FKBP5 MMP13 MUC1 NLRP1 SDK1 STK11 0.909 0.811 0.851 0.874 HFE IL6 NFKB1 NR3C1 STK11 TGFB1 0.802 0.913 0.851 0.821 HFE IL6 NR3C1 SLC40A1 STK11 TGFB1 0.803 0.913 0.851 0.821 HAMP HFE IL10 IL6 NFKB2 STK11 0.779 0.943 0.851 0.803 CCL27 IL1A MUC1 RGS2 SDK1 SLC40A1 0.775 0.955 0.851 0.793 GCKR HFE IL10 MUC1 NFKB1 STK11 0.838 0.87 0.851 0.865 IL10 MUC1 NFKB2 SKA2 STK11 TGFB1 0.839 0.871 0.851 0.854 IL10 MMP13 NFKB1 SLC11A2 SLC6A3 STK11 0.824 0.886 0.851 0.86 CASP9 EPO RGS2 SLC40A1 STK11 TNF 0.792 0.928 0.851 0.826 CASP9 NFKB2 RGS2 SLC40A1 STK11 VEGFA 0.789 0.928 0.851 0.832 CASP1 HAMP IL1A MUC1 NLRP1 STK11 0.828 0.884 0.851 0.828 CASP9 HFE IL6 MMP13 SLC40A1 STK11 0.852 0.857 0.851 0.873 CD274 IL10 NFKB1 PAX8 SLC22A4 STK11 0.814 0.898 0.851 0.849 FGFR2 FKBP5 HAMP IL10 STK11 TGFB1 0.819 0.902 0.851 0.806 IL10 IL18 MMP13 NFKB1 SLC22A4 STK11 0.852 0.857 0.851 0.84 IL10 MUC1 SIRT1 STK11 TGFB1 TNF 0.822 0.902 0.851 0.802 CASP9 HFE NLRP1 RGS2 SIRT1 STK11 0.839 0.869 0.851 0.857 CCL27 IL1A PAX8 RGS2 SDK1 SLC40A1 0.751 0.986 0.851 0.777 CRHR1 MUC1 RGS2 SDK1 SKA2 SLC40A1 0.75 0.986 0.851 0.764 HFE IL10 KRT1 NFKB1 STK11 VEGFA 0.836 0.87 0.851 0.829 IL10 MUC1 NFKB1 SKA2 STK11 VEGFA 0.801 0.912 0.851 0.862 ABCA1 EPO IL10 MUC1 NFKB1 STK11 0.799 0.912 0.851 0.844 CRHR1 GCKR IL10 MUC1 NFKB1 STK11 0.799 0.914 0.851 0.857 HAMP IL10 IL6 SLC22A4 STK11 TNF 0.799 0.913 0.851 0.822 FKBP5 NLRP1 NR3C1 SIRT1 STK11 TNF 0.78 0.941 0.851 0.75 IL10 NFKB1 NLRP1 NLRP3 STK11 TGFB1 0.831 0.885 0.851 0.859 CASP9 CCL27 MMP13 SIRT1 SLC11A2 STK11 0.842 0.888 0.851 0.827 CASP9 EPO MMP13 SIRT1 SLC11A2 STK11 0.842 0.888 0.851 0.815 ABCA1 HFE IL10 NFKB1 SLC6A3 STK11 0.802 0.914 0.851 0.845 CASP9 IL10 KRT1 NFKB1 PPARG STK11 0.798 0.914 0.851 0.838 CD274 HAMP IL10 MUC1 NFKB2 STK11 0.797 0.914 0.851 0.835 CD274 IL10 MUC1 NFKB1 SMAD3 STK11 0.799 0.913 0.851 0.835 GCKR HAMP IL10 MUC1 NFKB2 STK11 0.797 0.914 0.851 0.838 HAMP IL10 MUC1 NFKB2 STK11 TNF 0.798 0.914 0.851 0.829 HAMP IL10 NFKB1 NFKB2 NLRP3 STK11 0.798 0.914 0.851 0.821 CASP1 IL10 NFKB1 NLRP3 SLC40A1 STK11 0.838 0.871 0.851 0.841 CCL27 IL10 IL1A MUC1 NFKB2 STK11 0.837 0.87 0.851 0.829 FGFR2 HFE IL10 IL6 NFKB1 STK11 0.837 0.87 0.851 0.843 GCKR HFE IL10 IL6 NFKB1 STK11 0.837 0.87 0.851 0.857 GH1 HFE IL10 IL6 NFKB1 STK11 0.835 0.87 0.851 0.857 EPO GCKR HAMP IL10 STK11 TNF 0.819 0.9 0.851 0.802 IL10 MUC1 NFKB1 STK11 TGFB1 TNF 0.807 0.914 0.851 0.828 CASP9 RGS2 SDK1 SLC40A1 STK11 VEGFA 0.808 0.913 0.851 0.837 ABCA1 IL10 MUC1 NLRP1 PAX8 STK11 0.813 0.898 0.851 0.812 HFE2 IL10 IL6 MUC1 NLRP1 STK11 0.813 0.898 0.851 0.841 IL10 IL6 MUC1 NLRP1 RGS2 STK11 0.813 0.898 0.851 0.835 CASP9 EPO MMP13 NLRP1 SLC11A2 STK11 0.835 0.87 0.851 0.874 IL10 MMP13 NLRP1 PPARG SLC22A4 STK11 0.811 0.9 0.851 0.832 CASP9 CCL27 HFE IL10 NLRP1 STK11 0.836 0.871 0.851 0.863 IL10 NFKB1 NFKB2 PPARG STK11 TGFB1 0.842 0.874 0.851 0.844 CACNA1C IL10 NFKB2 PAX8 SLC11A2 STK11 0.8 0.915 0.851 0.838 CD274 FKBP5 IL10 NFKB2 SLC11A2 STK11 0.799 0.915 0.851 0.82 HAMP IL10 IL6 SLC11A2 SLC22A4 STK11 0.801 0.914 0.851 0.847 CASP3 CASP9 MMP13 RGS2 SLC40A1 STK11 0.822 0.885 0.851 0.878 CCL27 HAMP IL18 MUC1 NLRP1 STK11 0.804 0.912 0.851 0.841 CCL27 HFE MMP13 RGS2 SLC40A1 SLC6A3 0.751 0.985 0.851 0.832 IL10 MUC1 NFKB2 NR3C1 SIRT1 STK11 0.769 0.955 0.851 0.818 ABCA1 CASP9 EPO IL10 NFKB1 STK11 0.798 0.913 0.851 0.861 CASP9 IL6 RGS2 SLC6A3 STK11 TGFB1 0.801 0.914 0.851 0.816 CASP1 IL10 IL1A MUC1 NFKB1 TNF 0.769 0.957 0.851 0.7 IL10 IL6 MUC1 NFKB1 NLRP1 STK11 0.802 0.912 0.851 0.847 ABCA1 HFE MMP13 MUC1 SKA2 STK11 0.802 0.912 0.851 0.827 FGFR2 FKBP5 RGS2 SLC40A1 SMAD3 STK11 0.81 0.899 0.851 0.837 GH1 IL10 KRT1 MUC1 NFKB1 STK11 0.799 0.912 0.851 0.823 MMP13 RGS2 SLC40A1 SLC6A3 SMAD3 STK11 0.801 0.912 0.851 0.868 KRT1 MMP13 NLRP1 RGS2 SLC11A2 STK11 0.885 0.827 0.851 0.863 HAMP NR3C1 PAX8 SIRT1 STK11 TGFB1 0.779 0.941 0.851 0.739 CASP9 EDAR HFE MMP13 SLC40A1 STK11 0.836 0.871 0.851 0.837 FGFR2 HFE MMP13 SDK1 SLC40A1 STK11 0.836 0.869 0.851 0.855 IL10 IL1B MMP13 MUC1 NFKB1 STK11 0.841 0.871 0.851 0.853 CASP9 GH1 IL10 NFKB1 PAX8 STK11 0.811 0.9 0.851 0.839 FKBP5 IL10 NR3C1 RGS2 SLC40A1 TGFB1 0.751 0.985 0.851 0.675 IL10 IL6 NR3C1 RGS2 SLC40A1 TGFB1 0.751 0.985 0.851 0.675 IL10 KRT83 NR3C1 RGS2 SLC40A1 TGFB1 0.751 0.985 0.851 0.672 IL10 NFKB1 NR3C1 RGS2 SLC40A1 TGFB1 0.751 0.985 0.851 0.678 IL10 NR3C1 RGS2 SLC22A4 SLC40A1 TGFB1 0.751 0.985 0.851 0.674 IL10 NR3C1 RGS2 SLC40A1 SMAD3 TGFB1 0.751 0.985 0.851 0.672 HAMP HFE IL10 MMP13 NFKB1 STK11 0.878 0.827 0.851 0.888 EDAR FKBP5 HFE IL10 NFKB1 STK11 0.837 0.869 0.851 0.831 HFE MMP13 NLRP1 SLC11A2 SLC40A1 STK11 0.837 0.87 0.851 0.849 ABCA1 FKBP5 IL10 NFKB1 SLC11A2 STK11 0.812 0.9 0.851 0.84 ADAMTS4 CASP9 EPO IL10 NFKB1 STK11 0.813 0.9 0.851 0.853 CACNA1C CASP9 EPO IL10 NFKB1 STK11 0.813 0.9 0.851 0.854 CASP9 EPO IL10 NFKB1 PAX8 STK11 0.813 0.9 0.851 0.851 EPO IL10 NFKB1 SLC11A2 SLC22A4 STK11 0.813 0.899 0.851 0.83 FKBP5 MMP13 NLRP1 SIRT1 SMAD3 STK11 0.872 0.842 0.851 0.823 IL10 MMP13 NFKB1 NLRP1 SIRT1 STK11 0.867 0.843 0.851 0.854 GCKR IGF1 IL10 MUC1 NFKB2 STK11 0.8 0.914 0.851 0.813 CASP9 CCL27 FGFR2 SIRT1 SLC11A2 STK11 0.783 0.944 0.851 0.812 CASP9 CCL27 IGF1 SIRT1 SLC11A2 STK11 0.783 0.944 0.851 0.804 MUC1 NLRP1 PAX8 PPARG SLC40A1 STK11 0.78 0.942 0.851 0.76 HFE MMP13 PAX8 SDK1 SLC40A1 STK11 0.84 0.869 0.851 0.84 GH1 IL10 NFKB1 NLRP3 PAX8 STK11 0.833 0.884 0.851 0.835 CASP9 IL10 NFKB1 PAX8 STK11 VEGFA 0.814 0.9 0.851 0.842 HFE IL10 MUC1 NFKB2 SLC11A2 STK11 0.811 0.899 0.851 0.812 HAMP IL10 PAX8 SLC11A2 SLC40A1 STK11 0.802 0.914 0.851 0.826 CACNA1C NR3C1 PAX8 SIRT1 SLC40A1 TGFB1 0.78 0.941 0.851 0.737 CRHR1 EPO NR3C1 PAX8 SIRT1 TGFB1 0.78 0.941 0.851 0.778 CRHR1 NR3C1 PAX8 SIRT1 STK11 TGFB1 0.78 0.941 0.851 0.763 EPO NR3C1 PAX8 SIRT1 SLC22A4 TGFB1 0.78 0.941 0.851 0.735 EPO NR3C1 PAX8 SIRT1 STK11 TGFB1 0.78 0.941 0.851 0.751 HFE IL6 NFKB1 SLC11A2 STK11 VEGFA 0.825 0.884 0.851 0.842 ADAMTS4 FKBP5 IL10 NFKB1 SLC40A1 STK11 0.816 0.9 0.851 0.841 ABCA1 CACNA1C HFE MMP13 MUC1 STK11 0.799 0.913 0.851 0.821 ADAMTS4 EDAR IL10 MUC1 NFKB2 STK11 0.799 0.913 0.851 0.808 CRHR1 HAMP IL10 NFKB1 NLRP3 STK11 0.8 0.914 0.851 0.86 IL10 IL1A MUC1 NFKB1 SLC40A1 STK11 0.801 0.913 0.851 0.843 ABCA1 HAMP IL10 RGS2 STK11 TGFB1 0.835 0.872 0.851 0.799 FGFR2 HFE NLRP1 SIRT1 SLC11A2 STK11 0.836 0.869 0.851 0.845 HAMP IL10 NFKB1 RGS2 SLC6A3 STK11 0.834 0.871 0.851 0.857 CASP3 IL6 NR3C1 RGS2 SLC40A1 TGFB1 0.761 0.97 0.851 0.677 FKBP5 HFE IL10 KRT1 NFKB1 STK11 0.837 0.869 0.851 0.85 ABCA1 CRHR1 MMP13 MUC1 NLRP1 SDK1 0.829 0.884 0.851 0.857 FKBP5 IL10 NFKB1 PAX8 SLC22A4 STK11 0.81 0.899 0.851 0.828 FKBP5 IL10 NFKB1 SLC22A4 STK11 VEGFA 0.81 0.899 0.851 0.842 CCL27 MUC1 NLRP1 SKA2 STK11 TGFB1 0.812 0.899 0.851 0.814 CCL27 MUC1 NLRP1 STK11 TGFB1 VEGFA 0.812 0.899 0.851 0.816 CASP9 EDAR IL10 KRT1 NFKB1 STK11 0.812 0.9 0.851 0.833 CCL27 MUC1 NLRP1 SIRT1 STK11 TNF 0.804 0.912 0.851 0.823 CASP9 HFE MMP13 NLRP3 SLC40A1 STK11 0.828 0.886 0.851 0.824 HFE IL10 NLRP1 NLRP3 SLC11A2 STK11 0.829 0.884 0.851 0.85 CCL27 IL10 MMP13 NFKB1 SIRT1 STK11 0.882 0.828 0.851 0.881 IL10 MMP13 NFKB1 PAX8 SIRT1 STK11 0.882 0.828 0.851 0.865 ABCA1 IL10 IL1B KRT1 MUC1 STK11 0.791 0.928 0.851 0.785 ABCA1 IL10 MUC1 NFKB2 SLC11A2 STK11 0.799 0.914 0.851 0.813 CD274 HAMP IL10 NFKB2 SLC11A2 STK11 0.8 0.917 0.851 0.841 GH1 HAMP IL10 NFKB2 SLC11A2 STK11 0.8 0.917 0.851 0.843 HAMP HFE IL10 MUC1 NLRP1 SDK1 0.8 0.913 0.851 0.825 CASP9 GH1 IL10 RGS2 SLC40A1 STK11 0.84 0.872 0.851 0.848 CCL27 GCKR IL6 RGS2 SLC40A1 STK11 0.855 0.855 0.851 0.856 ADAMTS4 MUC1 NFKB1 NR3C1 STK11 VEGFA 0.769 0.955 0.851 0.768 CASP1 GCKR MUC1 NFKB1 NR3C1 STK11 0.769 0.955 0.851 0.732 EPO MUC1 NFKB1 NR3C1 STK11 VEGFA 0.769 0.955 0.851 0.742 FGFR2 GCKR MUC1 NFKB1 NR3C1 STK11 0.769 0.955 0.851 0.73 GCKR GH1 MUC1 NFKB1 NR3C1 STK11 0.769 0.955 0.851 0.728 GCKR KRT1 MUC1 NFKB1 NR3C1 STK11 0.769 0.955 0.851 0.746 GCKR KRT83 MUC1 NFKB1 NR3C1 STK11 0.769 0.955 0.851 0.737 GCKR MUC1 NFKB1 NR3C1 STK11 VEGFA 0.769 0.955 0.851 0.74 HAMP MUC1 NFKB1 NR3C1 STK11 VEGFA 0.769 0.955 0.851 0.737 KRT1 MUC1 NFKB1 NR3C1 STK11 VEGFA 0.769 0.955 0.851 0.747 FGFR2 MUC1 NLRP1 RGS2 STK11 TGFB1 0.839 0.869 0.851 0.832 CACNA1C CASP9 MMP13 SLC6A3 STK11 TGFB1 0.867 0.845 0.851 0.846 CASP9 KRT1 MMP13 SLC6A3 STK11 TGFB1 0.867 0.845 0.851 0.823 ADAMTS4 CCL27 RGS2 SIRT1 SLC40A1 TGFB1 0.803 0.912 0.851 0.83 CRHR1 IL10 IL1B MMP13 MUC1 NLRP1 0.843 0.871 0.851 0.82 CASP3 HAMP MUC1 NLRP1 NR3C1 STK11 0.78 0.941 0.851 0.761 CACNA1C CASP9 NR3C1 SLC40A1 STK11 TNF 0.784 0.941 0.851 0.752 CASP9 NR3C1 SLC40A1 SMAD3 STK11 TNF 0.784 0.941 0.851 0.749 CD274 HFE IL10 IL6 NFKB1 STK11 0.836 0.87 0.851 0.831 CRHR1 HFE IL10 NFKB1 SDK1 STK11 0.835 0.871 0.851 0.84 HFE MMP13 NR3C1 SIRT1 STK11 TGFB1 0.838 0.87 0.851 0.818 RGS2 SIRT1 SKA2 SLC40A1 STK11 TGFB1 0.834 0.87 0.851 0.857 ADAMTS4 IL10 IL18 MUC1 NFKB1 STK11 0.8 0.912 0.851 0.819 CASP1 FGFR2 IL10 MUC1 NFKB1 STK11 0.801 0.913 0.851 0.84 CASP3 CASP9 HAMP IL10 SLC22A4 STK11 0.799 0.915 0.851 0.873 FKBP5 IL10 KRT83 MUC1 NFKB1 STK11 0.8 0.912 0.851 0.841 FKBP5 IL10 MUC1 NFKB1 NLRP3 STK11 0.8 0.912 0.851 0.851 FKBP5 IL10 MUC1 NFKB1 RGS2 STK11 0.8 0.912 0.851 0.851 GH1 IL10 MUC1 NFKB1 PAX8 STK11 0.8 0.912 0.851 0.844 IL10 KRT83 MUC1 NFKB1 PAX8 STK11 0.8 0.912 0.851 0.837 IL10 MMP13 RGS2 SLC40A1 SLC6A3 STK11 0.835 0.87 0.851 0.886 MUC1 RGS2 SDK1 SKA2 SLC40A1 VEGFA 0.752 0.985 0.851 0.782 CD274 EPO IL10 MMP13 NFKB1 STK11 0.848 0.857 0.851 0.86 FKBP5 IL6 RGS2 SLC11A2 SLC40A1 STK11 0.851 0.856 0.851 0.851 IL10 KRT1 MMP13 NFKB1 SMAD3 STK11 0.851 0.856 0.851 0.853 CASP9 HFE2 KRT1 RGS2 SLC40A1 STK11 0.825 0.884 0.851 0.83 CASP9 CCL27 MMP13 NLRP1 SLC22A4 STK11 0.879 0.827 0.851 0.867 MUC1 NLRP1 PAX8 SDK1 STK11 TGFB1 0.824 0.884 0.851 0.83 ABCA1 FKBP5 IL10 NFKB1 SMAD3 STK11 0.809 0.899 0.851 0.837 IL10 IL6 MUC1 NFKB1 SLC6A3 STK11 0.799 0.912 0.851 0.865 CASP3 HFE IL10 RGS2 SDK1 SLC40A1 0.751 0.986 0.851 0.775 HAMP HFE IGF1 IL10 NFKB1 STK11 0.836 0.87 0.851 0.847 HAMP IL10 NFKB1 SLC11A2 SMAD3 STK11 0.839 0.871 0.851 0.841 CRHR1 HAMP HFE IL10 MUC1 NLRP1 0.801 0.913 0.851 0.803 IGF1 IL10 MUC1 NLRP1 SLC22A4 STK11 0.789 0.926 0.851 0.828 SIRT1 SLC11A2 SLC40A1 SMAD3 STK11 VEGFA 0.78 0.943 0.851 0.81 CRHR1 IL10 MMP13 NFKB1 SIRT1 VEGFA 0.867 0.843 0.851 0.855 CASP3 CRHR1 IL10 MMP13 NFKB1 STK11 0.847 0.857 0.851 0.855 CASP9 CCL27 HFE2 IL10 STK11 VEGFA 0.804 0.915 0.851 0.796 FKBP5 MMP13 RGS2 SLC40A1 STK11 TGFB1 0.835 0.871 0.851 0.876 HFE2 IL10 MMP13 NFKB1 STK11 TNF 0.835 0.87 0.851 0.839 IL10 IL18 NFKB1 SIRT1 SLC40A1 STK11 0.839 0.872 0.851 0.822 CASP9 CD274 IL6 RGS2 SLC40A1 STK11 0.819 0.899 0.851 0.835 ABCA1 CD274 IL10 MUC1 PAX8 STK11 0.767 0.956 0.851 0.788 ABCA1 CD274 IL10 MUC1 RGS2 STK11 0.767 0.956 0.851 0.782 CASP9 CRHR1 FGFR2 RGS2 SLC40A1 STK11 0.789 0.928 0.851 0.813 GCKR NR3C1 SLC11A2 STK11 TNF VEGFA 0.784 0.941 0.851 0.742 HFE KRT1 MMP13 RGS2 SDK1 SLC40A1 0.763 0.972 0.851 0.808 CASP9 HAMP IL10 NLRP1 SMAD3 STK11 0.799 0.914 0.851 0.862 IL1B MMP13 RGS2 SDK1 SLC40A1 TGFB1 0.801 0.913 0.851 0.837 CCL27 MMP13 NLRP1 SIRT1 SLC11A2 STK11 0.884 0.827 0.851 0.856 CASP3 IL10 NFKB2 SIRT1 SLC11A2 STK11 0.817 0.902 0.851 0.844 CRHR1 HAMP IL10 SIRT1 STK11 TGFB1 0.817 0.902 0.851 0.786 CRHR1 HAMP IL10 SMAD3 STK11 TGFB1 0.817 0.902 0.851 0.803 FGFR2 GCKR HAMP IL10 STK11 TGFB1 0.818 0.902 0.851 0.794 KRT83 MUC1 NLRP1 NR3C1 STK11 TGFB1 0.779 0.941 0.851 0.789 CASP1 HFE IGF1 IL10 NFKB1 STK11 0.837 0.87 0.851 0.847 CCL27 NLRP1 RGS2 SDK1 SIRT1 STK11 0.833 0.87 0.851 0.836 CACNA1C IL10 NFKB1 NLRP3 PPARG STK11 0.814 0.9 0.851 0.803 IL10 NFKB1 NFKB2 NLRP3 SKA2 STK11 0.813 0.899 0.851 0.828 CASP3 CCL27 IL10 SLC11A2 SLC22A4 STK11 0.818 0.9 0.851 0.832 CD274 IL10 NFKB1 NLRP1 NR3C1 STK11 0.781 0.942 0.851 0.783 CASP9 IL1B NLRP1 PAX8 STK11 TGFB1 0.794 0.928 0.851 0.751 CASP9 IL10 MMP13 NLRP1 STK11 TGFB1 0.898 0.83 0.851 0.874 HAMP HFE IL10 IL1A NLRP1 SLC11A2 0.778 0.942 0.851 0.772 CASP1 IL10 SDK1 SLC40A1 SLC6A3 STK11 0.778 0.943 0.851 0.847 ADAMTS4 CASP9 MMP13 NFKB2 STK11 VEGFA 0.843 0.872 0.851 0.806 ADAMTS4 CASP9 IL10 NFKB1 SKA2 STK11 0.853 0.857 0.851 0.858 CASP9 EDAR IL10 NFKB1 SKA2 STK11 0.851 0.857 0.851 0.838 CASP9 IL10 MMP13 NFKB2 RGS2 STK11 0.884 0.83 0.851 0.857 CASP9 IL10 NFKB1 NLRP3 SKA2 STK11 0.853 0.857 0.851 0.854 CASP9 IL10 NFKB1 SKA2 SLC11A2 STK11 0.853 0.857 0.851 0.851 CASP9 IL10 NFKB1 SKA2 STK11 TNF 0.853 0.857 0.851 0.86 CCL27 FKBP5 IL6 NFKB1 STK11 TGFB1 0.878 0.827 0.851 0.852 CASP9 IGF1 RGS2 SKA2 SLC40A1 STK11 0.813 0.896 0.851 0.852 CASP9 RGS2 SKA2 SLC40A1 SLC6A3 STK11 0.813 0.896 0.851 0.855 IL10 RGS2 SDK1 SKA2 SLC40A1 TNF 0.75 0.985 0.851 0.804 CCL27 NLRP1 RGS2 SDK1 SMAD3 STK11 0.872 0.838 0.851 0.841 EDAR IL10 NFKB1 PAX8 SLC22A4 STK11 0.812 0.899 0.851 0.823 CD274 IL10 NFKB1 PAX8 SKA2 STK11 0.83 0.885 0.851 0.847 IL10 MMP13 MUC1 NLRP1 PPARG STK11 0.812 0.899 0.851 0.845 CCL27 FKBP5 HFE IL6 MMP13 SLC40A1 0.791 0.928 0.851 0.837 CCL27 MUC1 NR3C1 PAX8 SLC40A1 STK11 0.782 0.939 0.851 0.766 CASP1 MMP13 RGS2 SDK1 SLC40A1 STK11 0.836 0.869 0.851 0.885 CRHR1 IL10 IL18 NFKB1 PAX8 STK11 0.849 0.857 0.851 0.836 GCKR IL10 NFKB1 PAX8 SLC11A2 STK11 0.838 0.872 0.851 0.846 ADAMTS4 HAMP IL10 NFKB1 PAX8 STK11 0.825 0.885 0.851 0.835 ABCA1 CCL27 IL10 IL1B MUC1 STK11 0.792 0.927 0.851 0.792 HAMP HFE HFE2 MUC1 NLRP1 STK11 0.788 0.926 0.851 0.817 MMP13 MUC1 NFKB1 NLRP1 SLC6A3 STK11 0.801 0.912 0.851 0.84 ABCA1 HFE IL1B IL6 RGS2 SLC40A1 0.759 0.971 0.851 0.821 HFE IL6 RGS2 SKA2 SLC40A1 SLC6A3 0.76 0.971 0.851 0.783 FGFR2 HFE2 IL10 MMP13 NFKB1 STK11 0.851 0.856 0.851 0.852 CCL27 IL10 IL6 MUC1 NLRP1 STK11 0.824 0.884 0.851 0.854 CASP9 EDAR PAX8 RGS2 SLC40A1 STK11 0.825 0.885 0.851 0.82 GH1 PPARG RGS2 SLC40A1 STK11 TGFB1 0.825 0.885 0.851 0.8 CCL27 HFE IL10 NFKB1 STK11 TNF 0.837 0.87 0.851 0.838 HAMP IL10 MMP13 NFKB1 NLRP1 STK11 0.854 0.857 0.851 0.844 ABCA1 IL10 NFKB1 NLRP3 SLC11A2 STK11 0.797 0.914 0.851 0.818 CASP3 HFE2 IL10 MUC1 NFKB1 STK11 0.799 0.912 0.851 0.854 EPO IL10 NFKB1 RGS2 SLC6A3 STK11 0.797 0.914 0.851 0.84 IL10 MUC1 NFKB2 SDK1 SLC40A1 STK11 0.798 0.913 0.851 0.831 IGF1 IL10 MMP13 NLRP1 SLC11A2 STK11 0.838 0.871 0.851 0.832 CACNA1C NR3C1 SDK1 SIRT1 SLC11A2 SLC40A1 0.779 0.942 0.85 0.714 NR3C1 SDK1 SIRT1 SLC11A2 SLC40A1 TNF 0.779 0.942 0.85 0.714 CASP9 NFKB2 NLRP1 RGS2 SLC40A1 STK11 0.827 0.885 0.85 0.858 HAMP IL10 MUC1 NFKB2 STK11 TGFB1 0.813 0.9 0.85 0.827 CASP9 FKBP5 MMP13 SLC11A2 STK11 VEGFA 0.831 0.886 0.85 0.834 EPO IL10 IL18 MMP13 NLRP1 STK11 0.827 0.885 0.85 0.825 CASP9 FGFR2 PAX8 RGS2 SLC40A1 STK11 0.821 0.885 0.85 0.814 CRHR1 GCKR IL10 NFKB1 NR3C1 STK11 0.811 0.899 0.85 0.807 IL10 MMP13 NFKB1 NLRP1 STK11 VEGFA 0.849 0.856 0.85 0.851 IL10 MMP13 NFKB1 SLC22A4 SMAD3 STK11 0.849 0.856 0.85 0.867 CASP1 HFE IL10 MUC1 SDK1 SLC40A1 0.778 0.942 0.85 0.805 CASP9 GCKR MUC1 NLRP1 NR3C1 STK11 0.779 0.943 0.85 0.778 CASP3 CCL27 IL6 NLRP1 RGS2 SLC40A1 0.777 0.956 0.85 0.769 CASP9 EPO FKBP5 RGS2 SLC40A1 STK11 0.792 0.928 0.85 0.848 CASP3 CCL27 HFE2 RGS2 SLC40A1 VEGFA 0.761 0.97 0.85 0.777 CACNA1C IL10 NLRP1 SKA2 SLC11A2 STK11 0.821 0.9 0.85 0.848 KRT1 KRT83 NR3C1 PAX8 SIRT1 TGFB1 0.779 0.941 0.85 0.758 HFE IL10 MMP13 NFKB1 SDK1 STK11 0.877 0.827 0.85 0.865 IL10 MMP13 NFKB1 SLC6A3 STK11 TGFB1 0.878 0.831 0.85 0.87 CCL27 IL10 NFKB1 SLC6A3 STK11 TGFB1 0.84 0.874 0.85 0.856 HFE IGF1 IL10 NFKB1 STK11 VEGFA 0.835 0.869 0.85 0.836 CD274 IL10 NFKB1 NLRP3 SLC6A3 STK11 0.802 0.914 0.85 0.84 HAMP IL6 MMP13 NFKB1 SLC40A1 STK11 0.891 0.826 0.85 0.837 CASP9 HFE IL10 IL1B NFKB1 STK11 0.809 0.9 0.85 0.831 FKBP5 HFE IL6 NFKB1 SLC6A3 STK11 0.8 0.913 0.85 0.867 HFE IL6 MUC1 NLRP3 SLC40A1 STK11 0.803 0.914 0.85 0.853 GH1 HFE2 IL6 RGS2 SKA2 SLC40A1 0.76 0.97 0.85 0.75 ABCA1 EPO HFE SIRT1 SLC11A2 STK11 0.798 0.913 0.85 0.751 ABCA1 CASP9 IL10 MUC1 STK11 TGFB1 0.799 0.914 0.85 0.827 CACNA1C CRHR1 IL10 NFKB1 SDK1 STK11 0.821 0.885 0.85 0.825 CRHR1 GH1 IL10 NFKB1 SLC6A3 STK11 0.799 0.914 0.85 0.854 FGFR2 HFE IL6 SLC11A2 SLC40A1 STK11 0.811 0.9 0.85 0.852 HFE2 IL10 NFKB1 PAX8 SLC6A3 STK11 0.808 0.9 0.85 0.847 HFE2 IL10 RGS2 SLC40A1 SLC6A3 STK11 0.811 0.9 0.85 0.831 CASP9 HFE2 IL10 MMP13 NLRP1 STK11 0.884 0.842 0.85 0.886 CCL27 HFE IL1B MMP13 RGS2 SLC40A1 0.777 0.942 0.85 0.86 ABCA1 HFE MUC1 PAX8 SLC40A1 STK11 0.78 0.942 0.85 0.805 HFE MUC1 NFKB1 RGS2 SLC40A1 STK11 0.78 0.942 0.85 0.82 CASP9 GCKR IL10 NFKB2 NR3C1 STK11 0.816 0.9 0.85 0.819 ABCA1 CCL27 IL6 RGS2 SLC40A1 STK11 0.854 0.855 0.85 0.859 CCL27 FKBP5 IL10 NFKB1 PAX8 STK11 0.852 0.855 0.85 0.832 FGFR2 NFKB2 RGS2 SLC40A1 STK11 TNF 0.777 0.941 0.85 0.811 FGFR2 HFE IL6 MMP13 NFKB1 STK11 0.868 0.838 0.85 0.864 MMP13 NR3C1 RGS2 SLC40A1 SMAD3 STK11 0.811 0.899 0.85 0.819 IL10 KRT83 NFKB1 PAX8 SMAD3 STK11 0.811 0.898 0.85 0.837 CACNA1C FKBP5 IL10 NFKB1 PAX8 STK11 0.83 0.883 0.85 0.841 NR3C1 SLC11A2 SLC22A4 STK11 TNF VEGFA 0.78 0.941 0.85 0.744 GH1 HAMP IL1A NR3C1 PAX8 TGFB1 0.789 0.927 0.85 0.669 HAMP IL1A KRT1 NR3C1 PAX8 TGFB1 0.789 0.927 0.85 0.703 IL1A MMP13 NLRP1 RGS2 SLC11A2 STK11 0.886 0.826 0.85 0.848 FKBP5 IL10 KRT1 NFKB1 NFKB2 STK11 0.822 0.885 0.85 0.835 CACNA1C GCKR IL10 MMP13 NFKB1 STK11 0.851 0.857 0.85 0.854 ABCA1 CASP9 IL10 NFKB1 NLRP3 STK11 0.798 0.914 0.85 0.838 ABCA1 MUC1 NLRP1 SDK1 SLC6A3 STK11 0.816 0.898 0.85 0.861 CACNA1C IL10 MUC1 NFKB2 NLRP1 STK11 0.799 0.912 0.85 0.83 IL10 IL1B MUC1 NFKB1 NR3C1 STK11 0.798 0.913 0.85 0.825 KRT1 MUC1 NLRP1 SDK1 SLC6A3 STK11 0.816 0.898 0.85 0.85 CASP1 HFE IL10 MMP13 NFKB1 STK11 0.881 0.827 0.85 0.868 CASP9 IL18 IL1B NLRP1 SLC6A3 STK11 0.77 0.958 0.85 0.766 ABCA1 CASP9 PAX8 RGS2 SLC40A1 STK11 0.822 0.886 0.85 0.818 ABCA1 IL10 SLC11A2 STK11 TGFB1 VEGFA 0.813 0.9 0.85 0.822 CASP9 CCL27 IL10 NFKB1 PAX8 STK11 0.81 0.9 0.85 0.835 CASP9 GH1 IL10 NFKB1 STK11 TNF 0.813 0.9 0.85 0.832 CD274 EPO IL10 NFKB1 SLC11A2 STK11 0.813 0.9 0.85 0.842 HAMP IL10 MUC1 NFKB1 SLC6A3 STK11 0.798 0.913 0.85 0.864 IL10 IL1B PPARG RGS2 SLC40A1 STK11 0.813 0.9 0.85 0.849 IL10 MUC1 NFKB1 NLRP1 SLC6A3 STK11 0.797 0.913 0.85 0.838 ABCA1 HAMP MUC1 NLRP1 NR3C1 STK11 0.779 0.941 0.85 0.751 CASP3 IGF1 MUC1 NLRP1 NR3C1 STK11 0.779 0.941 0.85 0.757 CASP9 CCL27 SIRT1 SLC11A2 STK11 TGFB1 0.821 0.9 0.85 0.801 IL10 NFKB1 NFKB2 NR3C1 SLC40A1 STK11 0.779 0.941 0.85 0.791 MUC1 NLRP1 NR3C1 SKA2 STK11 VEGFA 0.779 0.941 0.85 0.76 KRT1 MMP13 NLRP1 NLRP3 SLC11A2 STK11 0.838 0.871 0.85 0.851 ABCA1 HFE IL10 MMP13 NFKB1 STK11 0.838 0.869 0.85 0.892 IL10 NFKB2 SLC11A2 SMAD3 STK11 TGFB1 0.846 0.874 0.85 0.838 ADAMTS4 IL10 NFKB1 NLRP3 SLC40A1 STK11 0.804 0.913 0.85 0.834 CD274 NLRP1 NR3C1 SIRT1 STK11 TNF 0.78 0.941 0.85 0.764 CCL27 MMP13 NLRP1 RGS2 STK11 TGFB1 0.868 0.84 0.85 0.878 FKBP5 IL10 NFKB1 SLC11A2 SLC40A1 STK11 0.81 0.9 0.85 0.861 HAMP IL18 MMP13 NLRP1 SLC11A2 STK11 0.811 0.902 0.85 0.847 CCL27 MMP13 NFKB2 RGS2 SDK1 SLC40A1 0.775 0.957 0.85 0.825 CCL27 MMP13 PAX8 RGS2 SDK1 SLC40A1 0.775 0.957 0.85 0.847 CCL27 MMP13 RGS2 SDK1 SLC22A4 SLC40A1 0.775 0.957 0.85 0.823 IL6 MMP13 NLRP1 SIRT1 SLC11A2 STK11 0.882 0.827 0.85 0.866 CCL27 IL18 RGS2 SLC11A2 SLC40A1 STK11 0.825 0.884 0.85 0.813 CASP9 IL1A MMP13 MUC1 NLRP1 STK11 0.836 0.87 0.85 0.862 CASP9 IL10 MUC1 NFKB1 SLC6A3 STK11 0.798 0.914 0.85 0.867 CASP9 IL10 PPARG RGS2 SLC40A1 STK11 0.812 0.9 0.85 0.84 ADAMTS4 IL10 MUC1 NFKB2 NLRP1 STK11 0.8 0.913 0.85 0.821 CASP1 FGFR2 HAMP IL10 STK11 TNF 0.793 0.929 0.85 0.807 GH1 IL10 IL18 MUC1 NFKB1 STK11 0.798 0.912 0.85 0.821 IL10 IL18 KRT83 MUC1 NFKB1 STK11 0.798 0.912 0.85 0.805 IL10 IL18 MUC1 NFKB1 STK11 VEGFA 0.798 0.913 0.85 0.835 IL10 MUC1 NFKB1 NLRP1 SLC22A4 STK11 0.798 0.912 0.85 0.833 GCKR MUC1 NLRP1 NR3C1 SLC11A2 STK11 0.778 0.942 0.85 0.766 CCL27 RGS2 SLC11A2 SLC40A1 SMAD3 STK11 0.809 0.898 0.85 0.839 CRHR1 MUC1 NLRP1 SDK1 SLC40A1 STK11 0.817 0.898 0.85 0.829 CACNA1C IL10 NFKB1 PAX8 SLC6A3 STK11 0.81 0.9 0.85 0.853 EPO HAMP IL10 RGS2 SLC40A1 STK11 0.81 0.899 0.85 0.865 GH1 IL10 NFKB1 NLRP3 PPARG STK11 0.811 0.899 0.85 0.799 HAMP IL10 MUC1 NFKB1 SLC11A2 STK11 0.812 0.898 0.85 0.866 FKBP5 IL10 MUC1 NLRP1 RGS2 STK11 0.824 0.883 0.85 0.839 CRHR1 MMP13 NLRP1 SIRT1 SLC11A2 SLC40A1 0.84 0.872 0.85 0.852 HAMP IL10 MMP13 NLRP1 SMAD3 STK11 0.839 0.871 0.85 0.836 CCL27 HFE HFE2 MUC1 NR3C1 SLC40A1 0.784 0.939 0.85 0.761 CCL27 HFE MUC1 NFKB2 NR3C1 SLC40A1 0.784 0.939 0.85 0.758 CCL27 HFE MUC1 NR3C1 SLC40A1 VEGFA 0.784 0.939 0.85 0.753 CASP9 EPO NLRP1 RGS2 SLC40A1 STK11 0.825 0.896 0.85 0.854 CASP9 KRT1 NLRP1 RGS2 SLC40A1 STK11 0.825 0.896 0.85 0.844 ABCA1 GCKR MUC1 NFKB1 NR3C1 STK11 0.78 0.941 0.85 0.721 ABCA1 GCKR MUC1 NFKB2 NR3C1 STK11 0.78 0.941 0.85 0.739 ABCA1 MUC1 NFKB1 NR3C1 SKA2 STK11 0.78 0.941 0.85 0.73 ABCA1 MUC1 NFKB2 NR3C1 SKA2 STK11 0.78 0.941 0.85 0.767 CACNA1C CASP1 MUC1 NFKB1 NR3C1 STK11 0.78 0.941 0.85 0.729 CACNA1C CASP3 MUC1 NFKB2 NR3C1 STK11 0.78 0.941 0.85 0.732 CACNA1C EDAR MUC1 NFKB2 NR3C1 STK11 0.78 0.941 0.85 0.764 CACNA1C IGF1 MUC1 NFKB2 NR3C1 STK11 0.78 0.941 0.85 0.754 CACNA1C IL1B MUC1 NFKB2 NR3C1 STK11 0.78 0.941 0.85 0.748 CACNA1C MUC1 NFKB1 NR3C1 SKA2 STK11 0.78 0.941 0.85 0.739 CACNA1C MUC1 NFKB2 NR3C1 RGS2 STK11 0.78 0.941 0.85 0.731 CACNA1C MUC1 NFKB2 NR3C1 SKA2 STK11 0.78 0.941 0.85 0.778 CASP1 EPO MUC1 NFKB1 NR3C1 STK11 0.78 0.941 0.85 0.725 CASP1 FKBP5 MUC1 NFKB1 NR3C1 STK11 0.78 0.941 0.85 0.729 CASP1 GH1 MUC1 NFKB1 NR3C1 STK11 0.78 0.941 0.85 0.72 CASP1 HAMP MUC1 NFKB1 NR3C1 STK11 0.78 0.941 0.85 0.722 CASP1 IL1A MUC1 NFKB1 NR3C1 STK11 0.78 0.941 0.85 0.728 CASP1 KRT83 MUC1 NFKB1 NR3C1 STK11 0.78 0.941 0.85 0.73 CASP1 MUC1 NFKB1 NR3C1 SKA2 STK11 0.78 0.941 0.85 0.734 CASP3 FKBP5 MUC1 NFKB2 NR3C1 STK11 0.78 0.941 0.85 0.749 CASP3 GH1 MUC1 NFKB2 NR3C1 STK11 0.78 0.941 0.85 0.739 CASP3 HAMP MUC1 NR3C1 SLC40A1 STK11 0.78 0.941 0.85 0.754 CASP3 KRT83 MUC1 NFKB2 NR3C1 STK11 0.78 0.941 0.85 0.742 CASP3 MUC1 NFKB1 NFKB2 NR3C1 STK11 0.78 0.941 0.85 0.734 CASP3 MUC1 NFKB2 NR3C1 RGS2 STK11 0.78 0.941 0.85 0.728 CASP3 MUC1 NFKB2 NR3C1 SLC11A2 STK11 0.78 0.941 0.85 0.735 CASP3 MUC1 NR3C1 PAX8 SLC40A1 STK11 0.78 0.941 0.85 0.758 CD274 KRT83 MUC1 NFKB1 NR3C1 STK11 0.78 0.941 0.85 0.741 CD274 MUC1 NFKB1 NR3C1 SLC40A1 STK11 0.78 0.941 0.85 0.756 CRHR1 HFE MUC1 NFKB1 NR3C1 STK11 0.78 0.941 0.85 0.751 CRHR1 MUC1 NFKB1 NR3C1 SLC22A4 STK11 0.78 0.941 0.85 0.734 CRHR1 MUC1 NFKB2 NR3C1 SKA2 STK11 0.78 0.941 0.85 0.767 EDAR GCKR MUC1 NFKB2 NR3C1 STK11 0.78 0.941 0.85 0.753 EDAR HAMP MUC1 NFKB2 NR3C1 STK11 0.78 0.941 0.85 0.741 EDAR HFE MUC1 NFKB1 NR3C1 STK11 0.78 0.941 0.85 0.749 EDAR MUC1 NFKB2 NR3C1 SLC11A2 STK11 0.78 0.941 0.85 0.748 EPO KRT1 MUC1 NFKB1 NR3C1 STK11 0.78 0.941 0.85 0.735 EPO MUC1 NFKB2 NR3C1 RGS2 STK11 0.78 0.941 0.85 0.741 FGFR2 MUC1 NFKB2 NR3C1 SLC11A2 STK11 0.78 0.941 0.85 0.746 FKBP5 MUC1 NFKB2 NR3C1 RGS2 STK11 0.78 0.941 0.85 0.745 GCKR GH1 MUC1 NFKB2 NR3C1 STK11 0.78 0.941 0.85 0.739 GCKR HAMP MUC1 NFKB2 NR3C1 STK11 0.78 0.941 0.85 0.734 GCKR KRT83 MUC1 NFKB2 NR3C1 STK11 0.78 0.941 0.85 0.746 GCKR MUC1 NFKB2 NR3C1 RGS2 STK11 0.78 0.941 0.85 0.728 GH1 MUC1 NFKB1 NR3C1 RGS2 STK11 0.78 0.941 0.85 0.727 GH1 MUC1 NFKB2 NR3C1 RGS2 STK11 0.78 0.941 0.85 0.734 GH1 MUC1 NFKB2 NR3C1 SKA2 STK11 0.78 0.941 0.85 0.764 HAMP IL1B MUC1 NFKB2 NR3C1 STK11 0.78 0.941 0.85 0.731 HAMP MUC1 NFKB1 NR3C1 RGS2 STK11 0.78 0.941 0.85 0.71 HFE2 MUC1 NFKB2 NR3C1 RGS2 STK11 0.78 0.941 0.85 0.721 IL18 MUC1 NFKB2 NR3C1 SKA2 STK11 0.78 0.941 0.85 0.769 IL1B KRT83 MUC1 NFKB2 NR3C1 STK11 0.78 0.941 0.85 0.739 KRT1 MUC1 NFKB1 NR3C1 SKA2 STK11 0.78 0.941 0.85 0.744 KRT83 MUC1 NFKB1 NR3C1 RGS2 STK11 0.78 0.941 0.85 0.725 KRT83 MUC1 NFKB2 NR3C1 RGS2 STK11 0.78 0.941 0.85 0.734 MUC1 NFKB1 NFKB2 NR3C1 RGS2 STK11 0.78 0.941 0.85 0.733 MUC1 NFKB1 NFKB2 NR3C1 SKA2 STK11 0.78 0.941 0.85 0.763 MUC1 NFKB1 NR3C1 RGS2 STK11 VEGFA 0.78 0.941 0.85 0.744 MUC1 NFKB2 NR3C1 PAX8 RGS2 STK11 0.78 0.941 0.85 0.738 MUC1 NFKB2 NR3C1 RGS2 SKA2 STK11 0.78 0.941 0.85 0.757 MUC1 NFKB2 NR3C1 RGS2 SMAD3 STK11 0.78 0.941 0.85 0.714 MUC1 NR3C1 PAX8 SDK1 SLC40A1 STK11 0.78 0.941 0.85 0.78 IL10 MUC1 NFKB1 SLC6A3 STK11 TNF 0.797 0.912 0.85 0.852 IL10 MUC1 NFKB1 SLC6A3 SMAD3 STK11 0.797 0.912 0.85 0.862 ABCA1 CD274 IL10 MUC1 NLRP1 STK11 0.788 0.926 0.85 0.815 CASP1 HFE IL10 NR3C1 SLC11A2 STK11 0.778 0.942 0.85 0.752 HFE NLRP3 RGS2 SDK1 SIRT1 SLC40A1 0.778 0.942 0.85 0.773 CASP1 IL10 NFKB1 PAX8 SLC22A4 STK11 0.812 0.898 0.85 0.775 FKBP5 MUC1 NLRP1 NR3C1 SLC6A3 STK11 0.778 0.941 0.85 0.775 GCKR IL10 MUC1 NFKB1 NLRP3 STK11 0.799 0.912 0.85 0.844 IL18 IL1A MUC1 NLRP1 PAX8 STK11 0.798 0.913 0.85 0.817 CCL27 FGFR2 IL10 RGS2 SIRT1 SLC40A1 0.822 0.899 0.85 0.814 CASP3 CCL27 IL10 RGS2 SLC40A1 TNF 0.75 0.985 0.85 0.795 ABCA1 HFE IL10 MUC1 SDK1 STK11 0.798 0.912 0.85 0.825 ABCA1 IL10 MUC1 NFKB1 SLC6A3 STK11 0.797 0.913 0.85 0.858 EDAR HAMP IL10 NLRP1 SLC11A2 STK11 0.798 0.913 0.85 0.854 IL10 KRT1 MUC1 NFKB1 SLC6A3 STK11 0.797 0.913 0.85 0.855 IL10 MUC1 NFKB1 SLC11A2 SLC6A3 STK11 0.797 0.913 0.85 0.86 CASP9 CCL27 HAMP IL10 IL18 STK11 0.81 0.902 0.85 0.827 HFE MMP13 MUC1 NFKB2 SLC6A3 STK11 0.809 0.899 0.85 0.841 CASP1 FKBP5 HFE2 IL10 NFKB1 STK11 0.817 0.896 0.85 0.849 CACNA1C CCL27 MMP13 RGS2 SDK1 SLC40A1 0.763 0.971 0.85 0.821 CCL27 HFE2 MMP13 RGS2 SDK1 SLC40A1 0.763 0.971 0.85 0.82 CCL27 MMP13 RGS2 SDK1 SLC40A1 SMAD3 0.763 0.971 0.85 0.823 CASP3 FKBP5 NLRP1 SIRT1 SLC11A2 STK11 0.836 0.871 0.85 0.834 GCKR IL10 NFKB1 NLRP3 STK11 TGFB1 0.841 0.872 0.85 0.829 IL10 NFKB1 NLRP3 PAX8 STK11 TGFB1 0.841 0.872 0.85 0.84 IL10 IL6 MMP13 NFKB1 NLRP3 STK11 0.854 0.855 0.85 0.867 CASP1 FKBP5 HAMP IL10 NFKB1 STK11 0.822 0.884 0.85 0.849 EPO GH1 HAMP IL10 IL6 STK11 0.826 0.902 0.85 0.785 CCL27 IL10 IL1A MMP13 NFKB1 SIRT1 0.865 0.841 0.85 0.855 CRHR1 HFE IL10 IL1A NFKB1 SIRT1 0.867 0.843 0.85 0.825 CCL27 IL18 MUC1 NLRP1 STK11 VEGFA 0.801 0.912 0.85 0.825 CASP3 FKBP5 IL10 NFKB1 NLRP3 STK11 0.823 0.896 0.85 0.835 CASP9 FGFR2 IL10 NFKB1 NR3C1 STK11 0.811 0.899 0.85 0.835 CASP9 CCL27 IL10 NFKB1 SKA2 STK11 0.847 0.857 0.85 0.846 CCL27 CRHR1 IL10 MMP13 NFKB1 STK11 0.847 0.857 0.85 0.864 CRHR1 IL10 MMP13 NFKB1 SLC40A1 STK11 0.847 0.857 0.85 0.851 CRHR1 IL10 MMP13 NFKB1 STK11 VEGFA 0.847 0.857 0.85 0.86 CASP9 HFE IL6 RGS2 SDK1 SLC40A1 0.744 1 0.85 0.735 CCL27 EDAR RGS2 SDK1 SLC40A1 TNF 0.744 1 0.85 0.755 CCL27 HAMP RGS2 SDK1 SLC40A1 TNF 0.744 1 0.85 0.731 EDAR HFE IL6 RGS2 SDK1 SLC40A1 0.744 1 0.85 0.728 EPO GH1 HFE RGS2 SDK1 SLC40A1 0.744 1 0.85 0.769 EPO HFE IL1A RGS2 SDK1 SLC40A1 0.744 1 0.85 0.748 EPO HFE IL6 RGS2 SDK1 SLC40A1 0.744 1 0.85 0.742 FGFR2 HFE IL6 RGS2 SDK1 SLC40A1 0.744 1 0.85 0.735 FKBP5 HFE IL6 RGS2 SDK1 SLC40A1 0.744 1 0.85 0.737 FKBP5 HFE RGS2 SDK1 SLC22A4 SLC40A1 0.744 1 0.85 0.721 GH1 HFE IL1B NLRP1 SDK1 SLC40A1 0.744 1 0.85 0.667 GH1 HFE IL6 RGS2 SDK1 SLC40A1 0.744 1 0.85 0.762 GH1 HFE NLRP3 RGS2 SDK1 SLC40A1 0.744 1 0.85 0.768 GH1 HFE PAX8 RGS2 SDK1 SLC40A1 0.744 1 0.85 0.782 GH1 HFE RGS2 SDK1 SLC40A1 VEGFA 0.744 1 0.85 0.771 HFE IL1A IL6 RGS2 SDK1 SLC40A1 0.744 1 0.85 0.757 HFE IL1A NLRP3 RGS2 SDK1 SLC40A1 0.744 1 0.85 0.744 HFE IL6 NFKB2 RGS2 SDK1 SLC40A1 0.744 1 0.85 0.735 HFE IL6 NLRP3 RGS2 SDK1 SLC40A1 0.744 1 0.85 0.738 HFE IL6 PAX8 RGS2 SDK1 SLC40A1 0.744 1 0.85 0.751 HFE IL6 RGS2 SDK1 SLC40A1 TNF 0.744 1 0.85 0.714 HFE IL6 RGS2 SDK1 SLC40A1 VEGFA 0.744 1 0.85 0.741 HFE IL6 RGS2 SDK1 SLC40A1 SMAD3 0.744 1 0.85 0.754 IL18 MMP13 NLRP1 RGS2 SDK1 STK11 0.88 0.84 0.85 0.876 IL10 IL6 KRT1 MMP13 NFKB1 STK11 0.853 0.856 0.85 0.849 FKBP5 IL1A IL6 MUC1 NLRP1 STK11 0.797 0.913 0.85 0.813 CASP9 MMP13 NLRP1 RGS2 SLC22A4 STK11 0.895 0.826 0.85 0.89 EPO IL10 NFKB1 PAX8 SMAD3 STK11 0.811 0.899 0.85 0.836 IL10 IL1A MMP13 NFKB1 SLC6A3 STK11 0.809 0.899 0.85 0.843 CASP1 IL10 IL6 MUC1 SLC11A2 STK11 0.777 0.942 0.85 0.79 IL10 KRT1 MUC1 NFKB1 SLC40A1 STK11 0.777 0.942 0.85 0.831 IL10 MUC1 NFKB1 SLC11A2 SLC40A1 STK11 0.777 0.942 0.85 0.824 NFKB2 NLRP1 NR3C1 SIRT1 STK11 TNF 0.778 0.941 0.85 0.745 CASP1 HAMP IL10 MUC1 RGS2 STK11 0.778 0.943 0.85 0.792 EDAR FGFR2 NR3C1 STK11 TGFB1 TNF 0.793 0.927 0.85 0.753 EPO IL10 MMP13 MUC1 NLRP1 STK11 0.823 0.883 0.85 0.871 EDAR IL10 MUC1 NFKB1 SLC6A3 STK11 0.797 0.912 0.85 0.847 GH1 IL10 MUC1 NFKB1 SLC6A3 STK11 0.797 0.912 0.85 0.864 HFE2 IL10 MUC1 NFKB1 SLC6A3 STK11 0.797 0.912 0.85 0.854 IGF1 IL10 MUC1 NFKB1 SLC6A3 STK11 0.797 0.912 0.85 0.86 IL10 MUC1 NFKB1 NLRP3 SLC6A3 STK11 0.797 0.912 0.85 0.858 IL1B MMP13 PPARG RGS2 SIRT1 SLC40A1 0.797 0.912 0.85 0.856 CCL27 IL10 IL1B MMP13 RGS2 SLC40A1 0.814 0.899 0.85 0.881 CASP9 KRT1 NLRP1 SIRT1 SLC11A2 STK11 0.836 0.871 0.85 0.839 IL10 IL1A NFKB1 SLC11A2 SMAD3 STK11 0.835 0.87 0.85 0.813 FKBP5 GCKR IGF1 IL10 NFKB1 STK11 0.825 0.884 0.85 0.84 CCL27 IL18 MUC1 NLRP1 SKA2 STK11 0.801 0.912 0.85 0.839 ADAMTS4 GCKR IL10 IL1A NFKB1 STK11 0.809 0.899 0.85 0.814 CASP9 CCL27 FGFR2 IL10 STK11 VEGFA 0.802 0.915 0.85 0.806 CASP9 IL10 RGS2 SKA2 SLC22A4 STK11 0.838 0.886 0.85 0.841 IL10 NFKB2 PPARG SLC11A2 STK11 VEGFA 0.811 0.902 0.85 0.832 NR3C1 RGS2 SDK1 SLC40A1 SMAD3 STK11 0.811 0.899 0.85 0.805 CACNA1C CCL27 IL6 RGS2 SIRT1 SLC40A1 0.808 0.912 0.85 0.829 CD274 NR3C1 PAX8 SIRT1 STK11 TGFB1 0.777 0.941 0.85 0.758 EPO FGFR2 HAMP IL10 STK11 TNF 0.817 0.9 0.85 0.814 EPO HAMP IL10 STK11 TNF VEGFA 0.817 0.9 0.85 0.827 ABCA1 CCL27 IGF1 MUC1 NR3C1 SLC40A1 0.784 0.939 0.85 0.704 ABCA1 CCL27 IL1A MUC1 NR3C1 SLC40A1 0.784 0.939 0.85 0.726 ABCA1 CCL27 MUC1 NFKB2 NR3C1 SLC40A1 0.784 0.939 0.85 0.728 CCL27 IL10 NFKB1 SIRT1 SLC11A2 STK11 0.882 0.828 0.85 0.861 CACNA1C CASP9 IL6 MMP13 NFKB2 STK11 0.879 0.828 0.85 0.845 CASP9 CD274 HAMP IL10 STK11 TGFB1 0.83 0.886 0.85 0.864 GH1 IL10 IL6 MMP13 NFKB1 STK11 0.853 0.855 0.85 0.863 IL1B MMP13 RGS2 SIRT1 SLC40A1 SLC6A3 0.797 0.912 0.85 0.858 IL10 MMP13 NFKB1 NLRP3 SMAD3 STK11 0.849 0.856 0.85 0.859 IL10 MMP13 NFKB1 SMAD3 STK11 VEGFA 0.849 0.856 0.85 0.853 IL10 MMP13 NFKB1 RGS2 SLC40A1 STK11 0.848 0.855 0.85 0.895 CACNA1C HAMP IL10 NLRP1 STK11 VEGFA 0.774 0.943 0.85 0.794 HFE2 MUC1 NLRP1 SLC11A2 SLC6A3 STK11 0.776 0.942 0.85 0.829 CACNA1C HFE IL1B IL6 RGS2 SLC40A1 0.759 0.971 0.85 0.833 CASP1 HFE IL1B IL6 RGS2 SLC40A1 0.759 0.971 0.85 0.791 CASP3 HFE IL1B IL6 RGS2 SLC40A1 0.759 0.971 0.85 0.827 CASP9 HFE IL1B IL6 RGS2 SLC40A1 0.759 0.971 0.85 0.816 CCL27 IL1A PAX8 RGS2 SLC40A1 TNF 0.759 0.97 0.85 0.744 CCL27 IL1A RGS2 SKA2 SLC40A1 TNF 0.759 0.97 0.85 0.765 CCL27 NFKB1 RGS2 SLC40A1 TGFB1 TNF 0.759 0.971 0.85 0.799 EDAR HFE IL1B IL6 RGS2 SLC40A1 0.759 0.971 0.85 0.823 FGFR2 HFE IL1B IL6 RGS2 SLC40A1 0.759 0.971 0.85 0.813 FKBP5 HFE IL1B IL6 RGS2 SLC40A1 0.759 0.971 0.85 0.827 GCKR HFE IL1B IL6 RGS2 SLC40A1 0.759 0.971 0.85 0.811 HFE HFE2 IL1B IL6 RGS2 SLC40A1 0.759 0.971 0.85 0.828 HFE IL1B IL6 NFKB2 RGS2 SLC40A1 0.759 0.971 0.85 0.827 HFE IL1B IL6 NLRP1 RGS2 SLC40A1 0.759 0.971 0.85 0.828 HFE IL1B IL6 RGS2 SLC11A2 SLC40A1 0.759 0.971 0.85 0.815 HFE IL1B IL6 RGS2 SLC22A4 SLC40A1 0.759 0.971 0.85 0.83 HFE IL1B IL6 RGS2 SLC40A1 VEGFA 0.759 0.971 0.85 0.806 HFE IL1B IL6 RGS2 SLC40A1 TGFB1 0.759 0.971 0.85 0.82 HFE IL1B IL6 RGS2 SLC40A1 SMAD3 0.759 0.971 0.85 0.823 ABCA1 CASP1 IL10 IL1B MUC1 STK11 0.767 0.956 0.85 0.763 ABCA1 CASP3 IL10 MUC1 NR3C1 STK11 0.779 0.942 0.85 0.785 EPO IL10 MUC1 NFKB1 SLC40A1 STK11 0.779 0.942 0.85 0.829 CASP9 IL10 MMP13 NFKB1 RGS2 STK11 0.849 0.857 0.85 0.858 HFE IL10 IL18 NFKB1 PAX8 STK11 0.847 0.856 0.85 0.835 HFE IL10 NFKB1 PAX8 SLC11A2 STK11 0.847 0.856 0.85 0.833 ABCA1 HFE IL1B RGS2 SKA2 SLC40A1 0.759 0.97 0.85 0.801 CCL27 EPO HAMP IL10 STK11 TNF 0.815 0.9 0.85 0.814 CACNA1C CCL27 RGS2 SLC40A1 STK11 VEGFA 0.824 0.883 0.85 0.823 CASP9 HAMP IL10 IL6 STK11 TGFB1 0.852 0.874 0.85 0.82 CCL27 RGS2 SLC22A4 SLC40A1 STK11 VEGFA 0.824 0.883 0.85 0.853 HFE IL6 NLRP1 RGS2 STK11 TNF 0.841 0.869 0.85 0.854 CASP1 NLRP1 PAX8 SDK1 SIRT1 SLC40A1 0.756 0.972 0.85 0.793 IL1A NLRP3 RGS2 SDK1 SKA2 SLC40A1 0.76 0.972 0.85 0.774 ADAMTS4 IL10 NFKB1 SLC11A2 STK11 VEGFA 0.809 0.899 0.85 0.845 CASP3 CASP9 IL10 KRT1 NFKB1 STK11 0.808 0.9 0.85 0.831 CASP9 IL10 KRT1 NFKB1 STK11 TNF 0.808 0.9 0.85 0.814 Thus, expression of any of the above sets of six genes could differentiate between breast cancer vs. no cancer. References Angelo LS, Kurzrock R. 2007. Vascular endothelial growth factor and its relationship to inflammatory mediators. ClinCancer Res 13(10):2825–2830. Baird J.W., Nibbs R.J., Komai-Koma M., Connolly J.A., Ottersbach K., Clark-Lewis I., Liew F.Y., Graham G.J. ESkine, a novel beta-chemokine, is differentially spliced to produce secretable and nuclear targeted isoforms. J. Biol. Chem.1999;274:33496–33503. doi: 10.1074 / jbc.274.47.33496. Bell J.2004. Predicting disease using genomics. Nature.429:453-6. Babjuk M, Burger M, Comperat EM, Gontero P, Mostafid AH, Palou J, ...

Claims

What is claimed is:

1. A method of determining whether a patient has a cancer, the method comprising a) measuring an mRNA level of at least one gene in a tissue of the patient, wherein the at least one gene is CCL27, KRT1, NR3C1, CASP3, STK11, GCKR, SLC6A3, NFKB1, EDAR, GH1, IL1A, SIRT1, PPARG, CRHR1 or any combination thereof; and b) comparing the mRNA level determined in a) with the mRNA level of the at least one gene from a negative tissue from a subject not diagnosed with cancer; wherein the patient has cancer if the mRNA level determined in a) is greater than the mRNA level from the negative tissue.

2. The method of claim 1, further comprising b)i) comparing the mRNA level determined in a) with the mRNA level of the at least one gene from a positive tissue from a subject diagnosed with cancer; wherein the patient has cancer if the patient mRNA level in a) is greater than the mRNA level from the negative tissue and the patient mRNA level in a) is similar to the mRNA level from the positive tissue.

3. The method of claim 1, wherein the at least one gene is CCL27 and KRT1.

4. The method of claim 1, further comprising if the patient has cancer, determine a cancer type of the cancer and treat the patient treatment for the cancer or if the patient does not have cancer, recommend no cancer treatment.

5. The method of claim 1, wherein the cancer is bladder cancer, colon cancer, or breast cancer.

6. The method of claim 5, wherein the at least one gene is CCL27, KRT1, NR3C1, CASP3, STK11, GCKR, SLC6A3, NFKB1, EDAR, GH1, IL1A, SIRT1, PPARG, CRHR1 or any combination thereof. .

7. The method of claim 5, wherein the at least one gene is CCL27, KRT1, NR3C1, CASP3 or any combination thereof.

8. The method of claim 1, wherein the at least one gene is KRT1 and the method determines whether the patient has colorectal cancer.

9. The method of claim 1, further comprising recommending treatment for colorectal cancer if the patient has colorectal cancer and recommending no treatment for colorectal cancer if the patient does not have colorectal cancer.

10. The method of claim 1, further comprising treating the patient for colorectal cancer if the patient has colorectal cancer and treating the patient for another disease or disorder if the patient does not have colorectal cancer.

11. The method of claim 1, wherein the at least one gene is CRHR1 and the method determines whether the patient has breast cancer.

12. The method of claim 11, further comprising recommending treatment for breast cancer if the patient has breast cancer and recommending no treatment for breast cancer if the patient does not have breast cancer.

13. The method of claim 11, further comprising treating the patient for breast cancer if the patient has breast cancer and treating the patient for another disease or disorder if the patient does not have breast cancer.

14. The method of claim 1, wherein the at least one gene is CCL27, IL1A, KRT1, EDAR or any combination thereof, and the method determines whether the patient has bladder cancer.

15. The method of claim 14, further comprising recommending treatment for bladder cancer if the patient has bladder cancer and recommending no treatment for bladder cancer if the patient does not have bladder cancer.

16. The method of claim 14, further comprising treating the patient for bladder cancer if the patient has bladder cancer and treating the patient for another disease or disorder if the patient does not have bladder cancer.

17. The method of claim 1, wherein the at least one gene is CCL27, KRT1 or the combination thereof, and the method determines whether the patient has bladder, breast or colorectal cancer.

18. The method of claim 17, further comprising further testing the patient for cancer type if the method determines that the patient has bladder, breast or colorectal cancer.

19. A method of treating a cancer in a patient, the method comprising determining whether the patient has a cancer by the method of any one of claims 1-8, 11, 14, 17 or 18, then treating the cancer in the patient only if the method of any one of claims 1-8, 11, 14, 17 or 18 indicates that the patient has the cancer.

20. A method of determining whether a patient has a cancer, the method comprising a) measuring mRNA levels of (i) IL10, KRT1, MMP13, NFKB2, and STK11, and / or (ii) CCL27, KRT1, NR3C1, CASP3, and CRHR1 in a tissue of the patient; and b) comparing the mRNA levels determined in a) with (A) the mRNA levels of (i) and / or (ii) from a tissue from a subject not diagnosed with cancer and b) and (B) the mRNA levels of (i) and / or (ii) from tissue from a subject diagnosed with cancer; wherein the patient has cancer if the mRNA levels determined in a) is different than the mRNA levels determined in (A) and not different from the mRNA levels determined in (B), and the patient does not have cancer if the mRNA levels determined in a) is not different than the mRNA levels determined in (A) and different from the mRNA levels determined in (B).

21. The method of claim 20, further comprising if the patient has cancer, determine a cancer type of the cancer and treat the patient for the cancer or if the patient does not have cancer, recommend no cancer treatment.

22. The method of claim 20, wherein the cancer is breast cancer.

23. A method of treating a cancer in a patient, the method comprising determining whether the patient has a cancer by the method claim 20, then treating the cancer in the patient only if the method of claim 20 indicates that the patient has the cancer.

24. A method of determining whether a patient has breast cancer, the method comprisinga) measuring mRNA levels of any combination of (i) 5 genes listed in Table 9, or (ii) 6 genes listed in Table 10, in a tissue of the patient; and b) comparing the mRNA levels determined in a) with (A) the mRNA levels of the combination of 5 or 6 genes from a tissue from a subject not diagnosed with breast cancer and (B) the mRNA levels of the combination of 5 or 6 genes from tissue from a subject diagnosed with breast cancer; wherein the patient has breast cancer if the mRNA levels determined in a) is different than the mRNA levels determined in (A) and not different from the mRNA levels determined in (B), and the patient does not have breast cancer if the mRNA levels determined in a) is not different than the mRNA levels determined in (A) and different from the mRNA levels determined in (B).

25. The method of claim 24, wherein the combination of 5 genes or 6 genes are (i) IL1B, IL6, RGS2, SLC40A1 and STK11; (ii) IL10, MMP13, NLRP1, SLC11A2 and STK11; (iii) MMP13, NLRP1, SDK1, SLC11A2 and STK11; (iv) CASP9, IL1B, IL6, RGS2, SLC40A1 and STK11; (v) HAMP, IL10, RGS2, SLC22A4, STK11, andTGFB1; or (f) CASP9, MMP13, NLRP1, SIRT1, SLC11A2, and STK11.

26. A method of treating a cancer in a patient, the method comprising determining whether the patient has a cancer by the method claim 24, then treating the cancer in the patient only if the method of claim 24 indicates that the patient has the cancer.

27. A method of determining effectiveness of a treatment of a patient for cancer, the method comprising measuring a first mRNA level of at least one gene in a tissue of the patient before the treatment, wherein the at least one gene is CCL27, KRT1, NR3C1, CASP3, STK11, GCKR, SLC6A3, NFKB1, EDAR, GH1, IL1A, SIRT1, PPARG, CRHR1 or the combination thereof; treating the patient with the treatment; measuring a second mRNA level of the at least one gene in the tissue of the patient after the treatment; and comparing the first mRNA level with the second mRNA level, wherein if the first mRNA level is lower than the second mRNA level with any of the genes except IL1A and / or EDAR, and / or if the first mRNA level of IL1A and / or EDAR is greater than the second mRNA level, then the treatment is effective, andif the first mRNA level is not lower than the second mRNA level with any of the genes except IL1A and / or EDAR, and / or if the first mRNA level of IL1A and / or EDAR is not greater than the second mRNA level, then the treatment is not effective.

28. The method of claim 27, wherein the at least one gene is CCL27 and KRT1.

29. The method of claim 27, wherein the cancer is bladder, breast or colorectal cancer.

30. The method of claim 27, wherein the at least one gene is CCL27, KRT1, NR3C1, CASP3 or any combination thereof.

31. The method of claim 27, wherein the at least one gene is CCL27, KRT1 or the combination thereof.

32. The method of claim 27, wherein the at least one gene is KRT1 and the method determines whether the a treatment for colorectal cancer is effective.

33. The method of any one of claims 27 or 32, further comprising recommending continuing the treatment for colorectal cancer if the treatment for colorectal cancer is effective and recommending changing the treatment for colorectal cancer if treatment for colorectal cancer is not effective.

34. The method of any one of claims 27 or 33, further comprising continuing the treatment for colorectal cancer if the treatment for colorectal cancer is effective and changing the treatment for colorectal cancer if treatment for colorectal cancer is not effective.

35. The method of claim 27, wherein the at least one gene is CRHR1 and the method determines whether the treatment for breast cancer is effective.

36. The method of claim 27 or 35, further comprising recommending continuing the treatment for breast cancer if the treatment is effective and recommending changing the treatment for breast cancer if the treatment is not effective.

37. The method of any one of claim 27 or 35, further comprising continuing the treatment for breast cancer if the treatment is effective and changing the treatment for breast cancer if the treatment is not effective.

38. The method of claim 27, wherein the at least one gene is CCL27, IL1A, KRT1, EDAR or any combination thereof, and the method determines whether the treatment for bladder cancer is effective.

39. The method of claim 27 or 37, further comprising recommending continuing the treatment for bladder cancer if the treatment is effective and recommending changing the treatment for bladder cancer if treatment is not effective.

40. The method of any one of claims 27 or 38, further comprising continuing the treatment for bladder cancer if the treatment is effective and changing the treatment for bladder cancer if treatment is not effective.

41. A method of determining effectiveness of a treatment of a patient for cancer, the method comprising measuring first mRNA levels of (i) IL10, KRT1, MMP13, NFKB2, and STK11 and / or (ii) CCL27, KRT1, NR3C1, CASP3, and CRHR1 in a tissue of the patient before the treatment; treating the patient with the treatment; and measuring second mRNA levels of (i) and / or (ii) in the tissue of the patient after the treatment; comparing the first mRNA levels with the second mRNA levels, wherein if the second mRNA levels are more similar to mRNA levels of (i) and / or (ii) in the tissue of an individual without cancer than the mRNA levels before treatment, then the treatment is effective, or if the second mRNA level are not more similar to mRNA levels of (i) and / or (ii) in the tissue of an individual without cancer than the mRNA levels before treatment, then the treatment is not effective.

42. The method of claim 41, wherein the cancer is breast cancer.

43. A method of determining effectiveness of a treatment of a patient for breast cancer, the method comprising measuring first mRNA levels of any combination of (a) 5 genes listed in Table 9 or (b) 6 genes listed in Table 10, in a tissue of the patient before the treatment; treating the patient with the treatment;measuring second mRNA levels in the tissue of the patient after the treatment; and comparing the first mRNA levels with the second mRNA levels, wherein if the second mRNA levels are more similar to mRNA levels of the 5 or 6 genes in the tissue of an individual without breast cancer than the mRNA levels before treatment, then the treatment is effective, or if the second mRNA levels are not more similar to mRNA levels in the tissue of the individual without cancer than the mRNA levels before treatment, then the treatment is not effective.

44. The method of claim 39, wherein the combination of 5 genes or 6 genes are (i) IL1B, IL6, RGS2, SLC40A1 and STK11; (ii) IL10, MMP13, NLRP1, SLC11A2 and STK11; (iii) MMP13, NLRP1, SDK1, SLC11A2 and STK11; (iv) CASP9, IL1B, IL6, RGS2, SLC40A1 and STK11; (v) HAMP, IL10, RGS2, SLC22A4, STK11, andTGFB1; or (vi) CASP9, MMP13, NLRP1, SIRT1, SLC11A2, and STK11.

45. The method of any one of claims 41-43, further comprising recommending continuing the treatment if the treatment is effective and recommending changing the treatment if the treatment is not effective.

46. The method of any one of claims 41-43, further comprising continuing the treatment if the treatment is effective and changing the treatment if the treatment is not effective.

47. The method of any one of claims 1-46, wherein the mRNA source is a tumor.

48. The method of any one of claims 1-46, wherein the mRNA source is a bodily fluid.

49. The method of claim 48, wherein the bodily fluid is blood.

50. The method of claim 48, wherein the bodily fluid is saliva.

51. The method of claim 50, wherein the saliva is from a buccal swab.

52. The method of claim 51, wherein the buccal swab is stored for up to one year at any temperature between room temperature and -80 C inclusive.

53. The method of claim 49, wherein the buccal swab is stored for up to two years at any temperature between room temperature and -80 C inclusive.

54. A method for isolating RNA from a swab sample, the method comprising obtaining the swab sample, storing the swab sample for more than two weeks and up to two years at any temperature between room temperature and -80 C inclusive, then isolating the RNA from the swab sample.

55. The method of claim 54, wherein the yield of the RNA from the swab sample is similar to the yield obtained for the swab sample stored two weeks or less before the RNA is isolated.

56. The method of claim 54 or 55, wherein the swab sample is a buccal swab sample.

57. The method of any one of claims 54-56, wherein the swab sample is stored at room temperature.

58. The method of any one of claims 54-56, wherein the swab sample is stored below room temperature.

59. The method of any one of claims 54-56, wherein the swab sample is stored below 0°C.

60. The method of any one of claims 54-56, wherein the swab sample is stored at -80°C.

61. The method of any one of claims 54-60, wherein the swab sample is stored for more than one month.

62. The method of any one of claims 54-60, wherein the swab sample is stored for more than two months.

63. The method of any one of claims 54-60, wherein the swab sample is stored for more than six months.

64. The method of any one of claims 54-60, wherein the swab sample is stored for more than one year.

65. The method of any one of claims 54-60, wherein the swab sample is stored for up to 630 days.

66. The method of any one of claims 54-65, wherein the swabs inactivate microbial agents and denature proteins.

67. The method of any one of claims 54-66, wherein the swabs are Copan, Mawi, or Puritan swabs.

68. The method of claim 65, wherein the swabs are Copan swabs.

69. The method of claim 66, wherein the Copan swabs are Copan eNAT® swabs.

70. The method of any one of claims 52-67, wherein the swabs are flocked swabs.

71. An exosome comprising at least one siRNA targeting a gene, wherein the gene is CCL27, KRT1, NR3C1, CASP3, STK11, GCKR, SLC6A3, NFKB1, EDAR, GH1, IL1A, SIRT1, PPARG, CRHR1 or any combination thereof.

72. The exosome of claim 71, wherein the at least one gene is CCL27, KRT1, NR3C1, CASP3 or any combination thereof.

73. The exosome of claim 72, wherein the exosome inhibits breast, bladder or colorectal cancer when administered to a patient having breast, bladder or colorectal cancer.

74. The exosome of claim 71, wherein the at least one gene is KRT1.

75. The exosome of claim 74, wherein the exosome inhibits colorectal cancer when administered to a patient having colorectal cancer.

76. The exosome of claim 71, wherein the at least one gene is CCL27.

77. The exosome of claim 70 or 76 wherein the exosome inhibits skin cancer when administered to a patient having skin cancer.

78. The exosome of claim 77, wherein the skin cancer is melanoma.

79. The exosome of claim 76, wherein the exosome inhibits endometriosis when administered to a patient having endometriosis.

80. The exosome of claim 71, wherein the at least one gene is CRHR1.

81. The exosome of claim 73, wherein the exosome inhibits breast cancer when administered to a patient having breast cancer.

82. An exosome comprising at least one siRNA targeting a gene, wherein the gene is IL1A, EDAR or the combination thereof.

83. The exosome of claim 82, wherein the exosome inhibits bladder cancer when administered to a patient having bladder cancer.

84. An exosome comprising at least five siRNAs each targeting a gene, wherein the targeted genes are any combination of (a) 5 genes listed in Table 9 or (b) 6 genes listed in Table 10.

85. The exosome of claim 82, wherein the combination of 5 genes or 6 genes are (i) IL1B, IL6, RGS2, SLC40A1 and STK11; (ii) IL10, MMP13, NLRP1, SLC11A2 and STK11; (iii) MMP13, NLRP1, SDK1, SLC11A2 and STK11; (iv) CASP9, IL1B, IL6, RGS2, SLC40A1 and STK11; (v) HAMP, IL10, RGS2, SLC22A4, STK11, andTGFB1; or (vi) CASP9, MMP13, NLRP1, SIRT1, SLC11A2, and STK11.

86. A method of treating bladder cancer in a patient, the method comprising administering the exosome of claim 72 or 83 to the patient.

87. A method of treating colorectal cancer in a patient, the method comprising administering the exosome of claim 73 or 75 to the patient.

88. A method of treating breast cancer in a patient, the method comprising administering the exosome of claim 73, 81 or 84 to the patient.

89. A method of treating endometriosis in a patient, the method comprising administering the exosome of claim 79 to the patient.

90. A method of treating skin cancer in a patient, the method comprising administering the exosome of claim 77 to the patient.

91. The method of claim 90, wherein the skin cancer is melanoma.

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