Skin function improving agent, topical preparation for skin, cosmetic, and skin function improving agent composition

Abstract

Provided are: a novel and useful skin function improving agent; and a topical preparation for skin, a cosmetic, and a skin function improving agent composition each containing the skin function improving agent. A skin function improving agent according to the present disclosure contains an extract from red bayberry as an active ingredient. For example, the skin function improving agent promotes the formation of tight junctions or increases the expression of Claudin 1 gene. The present disclosure also provides a topical preparation for skin, a cosmetic, and a skin function improving agent composition, in each of which the skin function improving agent that contains an extract from red bayberry as an active ingredient is used.

Description

Skin function improving agent, skin topical preparation, cosmetic, and skin function improving agent composition

[0001] The present disclosure relates to a skin function improving agent, an external skin preparation, a cosmetic, and a skin function improving composition.

[0002] Skin has the function of mitigating external stimuli, such as dryness, ultraviolet rays, and other physical and chemical stimuli, and protecting against the loss of body components such as moisture. Various studies have been conducted to improve the skin's barrier function and moisturizing function. For example, Patent Document 1 proposes a claudin production promoter, an occludin production promoter, and a tight junction function enhancer containing Ishige as an active ingredient. It is claimed that the various promoters or function enhancers containing Ishige as an active ingredient proposed in Patent Document 1 can provide topical skin preparations effective for skin conditions such as dry skin, rough skin, atopic dermatitis, and various infectious diseases. Patent Document 2 also proposes a tight junction formation promoter containing mandarin orange extract as an active ingredient. Patent Document 3 also proposes a moisturizer containing, as an active ingredient, an inositol derivative in which three or more monosaccharide units are bound to one inositol molecule. The moisturizer proposed in Patent Document 3 is said to be able to improve the physiological moisturizing function of the epidermis by promoting the production of aquaporin-3, and to improve the skin's moisture retention function by promoting the production of ceramide and filaggrin.

[0003] Japanese Patent Application Laid-Open No. 2014-97959 Japanese Patent No. 6592715 Special Publication No. 2016-76310

[0004] A primary object of the present disclosure is to provide a novel and useful skin function improving agent, as well as an external skin preparation, cosmetic, and skin function improving agent composition containing this skin function improving agent.

[0005] A skin function improving agent according to one embodiment of the present disclosure contains a bayberry extract as an active ingredient. A skin function improving agent according to one embodiment of the present disclosure contains a bayberry extract as an active ingredient and promotes the formation of tight junctions. A skin function improving agent according to one embodiment of the present disclosure contains a bayberry extract as an active ingredient and increases the expression of the claudin-1 gene. A skin function improving agent according to one embodiment of the present disclosure contains a bayberry extract as an active ingredient and increases the expression of the aquaporin-3 gene and the filaggrin gene.

[0006] An external skin preparation according to an embodiment of the present disclosure contains a bayberry extract as an active ingredient.A cosmetic according to an embodiment of the present disclosure contains a bayberry extract as an active ingredient.A skin function improving agent composition according to an embodiment of the present disclosure contains a bayberry extract as an active ingredient.

[0007] The skin function improving agent of the present disclosure, as well as topical skin preparations, cosmetics, and skin function improving agent compositions containing this skin function improving agent, are novel and useful for improving skin function.

[0008] 1 shows the results of gene expression analysis of aquaporin 3, filaggrin, and claudin 1. Fluorescent immunostaining images of claudin 1 and ZO-1. A diagram showing the fluorescence intensity derived from claudin 1 normalized by cell number. A diagram showing changes in the fluorescence intensity value of ZO-1-derived signals. A diagram showing the quantification of the distribution of ZO-1-derived signals on a histogram sorted by the strength of pixel fluorescence intensity. A diagram showing the results of a human monitor test.

[0009] The skin function improving agent of the present disclosure, as well as topical skin preparations, cosmetics, and skin function improving composition containing the skin function improving agent, are specifically described below. Note that the embodiments described below do not limit the invention according to the claims, and not all of the elements and combinations thereof described in each embodiment are necessarily essential to the solution of the present disclosure.

[0010] <<Skin Function Improving Agent>> A skin function improving agent according to an embodiment of the present disclosure (hereinafter referred to as a skin function improving agent of one embodiment) contains a bayberry extract as an active ingredient. The terms "skin" and "skin function improving agent" used in this specification may be read as "skin," "epidermis," and "skin function improving agent," respectively. The skin function improving agent used in this specification includes skin function improving agents and epidermal function improving agents.

[0011] The skin function improving agent of one embodiment has the effect of promoting the formation of tight junctions. The skin function improving agent of one embodiment can be said to be a tight junction formation promoter containing a bayberry extract as an active ingredient. The skin function improving agent of one embodiment can promote the formation of tight junctions, and therefore, the skin barrier property (barrier function) can be enhanced by using the skin function improving agent of one embodiment.

[0012] A skin function improving agent of one embodiment has the effect of increasing the expression of the claudin-1 gene. The skin function improving agent of one embodiment can be said to be a claudin-1 gene production promoter containing a bayberry extract as an active ingredient. The skin function improving agent of one embodiment can promote the production of the claudin-1 gene, which is responsible for strand formation in tight junctions, and therefore, the skin barrier property can be improved by using the skin function improving agent of one embodiment.

[0013] The skin function improving agent of one embodiment has the effect of increasing the expression of the aquaporin 3 gene and the filaggrin gene. The skin function improving agent of one embodiment can be said to be a production promoter of the aquaporin 3 gene and the filaggrin gene, containing an extract of Bayberry as an active ingredient. The skin function improving agent of one embodiment can promote the production of the aquaporin 3 and the filaggrin gene, and therefore, the skin function improving agent of one embodiment can be used to increase the moisturizing property (moisturizing function) and water retention (water retention function) of the skin.

[0014] As used herein, "bayberry" refers to an evergreen tall tree belonging to the Myricaceae family. The variety of bayberry is not particularly limited, but examples include black peach, red peach, and white peach. Specific varieties include Zuikou (Kondo peach), Moriguchi, Koutou (Nishimura, Kobashi, etc.), Nakayama Wase, Kogyoku (Hiyama, Hinode), Gozen (Shirodango, Hakusawa), Awanishiki (Oni, Onidango), Kamezo, Ban'inyoubai, Tokai, Seitodo Daiyoubai, Tenga-sen, Yokawachi, Juroku, Taneyoubai, Chubaao, Dingxiangbai, and Daitanbai. Bayberry leaves, for example, are alternate, obovate-oblong or oblanceolate, tapered to a wedge-shaped base, leathery, with small oil spots on the underside, and usually entire. Young trees have sharp sawtooth. For example, the leaves of the Japanese bayberry have short petioles and are about 12 cm long.

[0015] As used herein, "bayberry extract" refers to an extract extracted from a bayberry extraction raw material (hereinafter referred to as the extraction raw material). Examples of extraction raw materials include bayberry leaves, bayberry fruits, bayberry trunks, bayberry branches, bayberry bark, and bayberry roots. Among these, bayberry leaves are suitable as an extraction raw material because they can be harvested regardless of the season and are available in large quantities. Either dried or fresh bayberry leaves may be used. When using bayberry leaves as an extraction raw material, it is preferable to use leaves that have been processed, such as by shredding or crushing. Using bayberry leaves that have been processed in this way can improve extraction efficiency.

[0016] There are no particular limitations on the extraction method for bayberry extract, and extraction can be performed by appropriately selecting a conventionally known extraction method using an extraction raw material and an extraction solvent, etc. For example, a bayberry extract can be obtained by mixing an extraction raw material (e.g., bayberry leaves) with an extraction solvent. The bayberry extract referred to in this specification includes not only the extract itself extracted using various extraction methods, diluted extracts, concentrated extracts, and diluted concentrates, but also dried and purified products thereof. There are no limitations on the form of the bayberry extract, and it can be in any form, such as liquid, paste, or solid.

[0017] (Extraction Solvent) Examples of extraction solvents include aqueous solvents, organic solvents, and mixtures thereof. Examples of aqueous solvents include purified water, hot water, ion-exchanged water, and other waters, as well as aqueous solutions typified by buffer solutions such as physiological saline, phosphate buffer, and phosphate-buffered physiological saline. Examples of organic solvents include lower alcohols or hydrous lower alcohols such as methanol, ethanol, propyl alcohol, isopropyl alcohol, butanol, and isobutanol; polyhydric alcohols or hydrous polyhydric alcohols such as 1,3-butylene glycol, 1,2-butylene glycol, 1,4-butylene glycol, 1,5-pentanediol, 1,2-pentanediol, 1,3-pentanediol, 1,4-pentanediol, 1,3,5-pentanetriol, glycerin, and polyethylene glycol; acetone, ethyl acetate, diethyl ether, dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, xylene, benzene, chloroform, carbon tetrachloride, phenol, and toluene.

[0018] The extraction solvent may be used alone or in combination of two or more. When two or more extraction solvents are used in combination, a mixed solvent of two or more extraction solvents may be used, or a combination of extractions using the extraction solvents may be used. Examples of combinations of extractions using extraction solvents include a combination of water extraction and organic solvent extraction, or a combination of one organic solvent extraction and another organic solvent extraction. As the extraction solvent, water, 1,3-butylene glycol, ethanol, ethyl acetate, and a mixed solvent (mixed solution) containing two or more of these can be suitably used.

[0019] (Extraction Conditions) There are no limitations on the extraction conditions, and they may be appropriately determined depending on the extraction solvent used. For example, an extract is obtained by adding 0.5 to 500 times the amount of the extraction solvent to the Bayberry extraction raw material (e.g., Bayberry leaves). For example, an extract is obtained by adding 100 to 250 times the amount of the extraction solvent to the Bayberry extraction raw material (e.g., Bayberry leaves).

[0020] In an example of extraction conditions, the temperature of the extraction solvent is 4 to 100°C. In an example of extraction conditions, extraction is performed under heated reflux. In an example of extraction conditions, extraction is performed at room temperature (25°C ± 2°C). In an example of extraction conditions, extraction time is 60 minutes to 2 days. In an example of extraction conditions, various treatments are performed to improve extraction efficiency when obtaining the extract. Examples of various treatments include stirring, pressurization, and ultrasonic treatment. In an example of extraction conditions, separation of the extract is performed. Examples of separation treatments include filtration and centrifugation. The filtrate obtained after filtering the extract may be used as a bayberry extract. In an example of extraction conditions, concentration of the extract (or filtrate) is performed. The concentrate obtained by concentration may be used as a bayberry extract. In an example of extraction conditions, dilution of the extract or filtrate is performed. The diluted solution obtained by dilution may be used as a bayberry extract. In an example of extraction conditions, purification is performed. Examples of purification processes include fractional extraction, partitioning between two solvents, fractional adsorption using an adsorbent, elution, and chromatography. An example of an extraction method involves liquid-liquid extraction to obtain a bayberry extract. An example of an extraction method involves liquid-liquid extraction. An example of an extraction method involves liquid-liquid extraction using ethyl acetate.

[0021] (Extraction Example) Next, an example of a specific method for extracting a bayberry extract using bayberry leaves (a method for producing a bayberry extract) will be described.

[0022] (Extraction Example 1) An extract is obtained by stirring 100 g of crushed dried bayberry leaves with 10 kg of 80% ethanol (8 kg of ethanol, 2 kg of distilled water) for 4 hours in an environment of 25°C ± 2°C. The extract is filtered through filter paper, and the filtrate is concentrated and then adjusted to 7 kg with distilled water, after which 3 kg of 1,3-butylene glycol is added to obtain a bayberry extract.

[0023] (Extraction Example 2) 10 kg of bayberry leaves were thinly sliced, and 10 kg of 30% w / w 1,3-butylene glycol prepared from 7 kg of distilled water and 3 kg of 1,3-butylene glycol was added thereto, and the mixture was heated to 70-80°C and maintained in this heated state for 4 hours to obtain an extract. The extract was filtered through filter paper, and distilled water was added to the filtrate to make a total volume of 10 kg, yielding a bayberry extract.

[0024] (Extraction Example 3) An extract is obtained by stirring 100 g of crushed dried bayberry leaves with 10 kg of 80% ethanol (8 kg of ethanol, 2 kg of distilled water) for 4 hours in an environment of 25°C ± 2°C. The extract is filtered through filter paper, and the filtrate is concentrated and then partitioned by adding ethyl acetate and distilled water. The ethyl acetate layer is concentrated and then dissolved in 10 kg of 30% w / w 1,3-butylene glycol to obtain a bayberry extract.

[0025] The skin function improving agent of one embodiment can be administered parenterally, for example, as an external preparation for skin. The external preparation for skin may be a cosmetic. One example of a method for applying the skin function improving agent of one embodiment is topical administration, preferably by direct application, sprinkling, or spraying onto the skin.

[0026] The types of topical skin preparations or cosmetics include hair cosmetics selected from shampoo, oil shampoo, cream shampoo, conditioning shampoo, anti-dandruff shampoo, hair color shampoo, rinse-in-one shampoo, rinse, treatment, hair pack, hair foam, hair mousse, hair spray, hair mist, hair wax, hair gel, water grease, setting lotion, color lotion, hair tonic, hair liquid, pomade, tic, hair cream, hair blow dryer, split end coat, hair oil, permanent wave agent, straight perm agent, oxidative hair dye, hair bleach, hair color pre-treatment, hair color after-treatment, perm pre-treatment, perm after-treatment, hair manicure, and hair growth agent;Facial cleanser, cleansing foam, washing powder, facial cleansing powder, cleansing cream, cleansing milk, cleansing lotion, cleansing gel, cleansing oil, cleansing mask, lotion, softening lotion, astringent lotion, cleansing lotion, multi-layered lotion, emulsion, emollient lotion, moisture lotion, milky lotion, nourishing lotion, nourishing milk, skin moisture, moisturizing emulsion, massage lotion, cleansing lotion, protective emulsion, sun protect, sun protector, UV care milk, sunscreen, makeup lotion, exfoliating smoother, elbow lotion, hand lotion, body lotion, cream, emollient cream, a basic cosmetic selected from nourishing cream, nourishing cream, vanishing cream, moisturizing cream, night cream, massage cream, cleansing cream, makeup cream, base cream, pre-makeup cream, sunscreen cream, suntan cream, hair removal cream, deodorant cream, shaving cream, exfoliating cream, gel, cleansing gel, moisturizing gel, soap, cosmetic soap, transparent soap, medicated soap, liquid soap, shaving soap, synthetic cosmetic soap, pack, mask, peel-off pack, powder pack, washing pack, oil pack, cleansing mask, essence, moisturizing essence, whitening essence, UV protection essence, liposome beauty serum, and liposome lotion; Makeup cosmetics selected from face powders, foundations, makeup bases, lipsticks, lip glosses, blushers, eyeliners, mascara, eye shadows, eyebrow pencils, nail enamel, enamel remover, and nail treatments; aromatic cosmetics selected from perfumes, parfums, eau de parfum, eau de toilette, eau de cologne, solid perfumes, aromatic powders, perfumed soaps, body lotions, and bath oils; body cosmetics selected from body shampoos, body washes, body powders, deodorant lotions, deodorant powders, deodorant sprays, deodorant sticks, deodorant cosmetics, bleaches, depilatories, bath additives, insect repellent sprays, and insect repellers;Examples include ointments, patches, lotions, liniments, and liquid applications.

[0027] Examples of dosage forms of topical skin preparations or cosmetics include emulsion types such as oil-in-water (O / W) type, water-in-oil (W / O) type, W / O / W type, and O / W / O type, emulsified polymer type, oil-based, solid, liquid, paste, stick-like, volatile oil type, powder, jelly, gel, paste, cream, sheet, film, mist, spray type, multilayer, foam, and flake-like forms.

[0028] <<Skin Function Improving Agent Composition>> A skin function improving agent composition according to an embodiment of the present disclosure (hereinafter referred to as a skin function improving agent composition of one embodiment) contains the skin function improving agent described above. The skin function improving agent composition of one embodiment contains the skin function improving agent of the above embodiment and a physiologically or pharmaceutically acceptable carrier. The skin function improving agent of one embodiment may be a skin topical agent or a cosmetic.

[0029] The skin function improving agent composition of one embodiment may contain raw materials described in existing raw material specifications or official compendia at a general concentration, for example, 100 ppm to 90 mass % relative to the total amount of the skin function improving agent of one embodiment. Examples of the above-mentioned raw materials include the 14th Revised Japanese Pharmacopoeia (edited by the Japan Pharmaceutical Association, published by Jiho Co., Ltd., April 2001), Commentary on the 2nd Edition of the Standards for Cosmetic Ingredients (edited by the Japan Pharmaceutical Association, published by Yakuji Nipposha, 1984), Standards for Non-Standard Ingredients in Cosmetic Ingredients (supervised by the Examination Division of the Pharmaceutical Affairs Bureau, Ministry of Health and Welfare, published by Yakuji Nipposha, 1993), Supplement to the Standards for Non-Standard Ingredients in Cosmetic Ingredients (supervised by the Examination Division of the Pharmaceutical Affairs Bureau, Ministry of Health and Welfare, published by Yakuji Nipposha, 1993), Approval Standards for Cosmetics by Type (supervised by the Examination Division of the Pharmaceutical Affairs Bureau, Ministry of Health and Welfare, published by Yakuji Nipposha, 1993), and International Cosmetic Ingredient Dictionary and Handbook 2002 Ninth Edition Vol. All raw materials listed in 1 to 4 by CTFA, the Dictionary of Cosmetic Raw Materials (published by Nikko Chemicals, 1991), etc. can be used.

[0030] Examples of physiologically or pharmaceutically acceptable carriers that can be used include one or more selected from excipients, binders, disintegrants, lubricants, emulsifiers, stabilizers, diluents, oily bases, moisturizers, texture improvers, surfactants, polymers, thickeners / gelling agents, solvents, propellants, antioxidants, reducing agents, oxidizing agents, chelating agents, acids, alkalis, powders, inorganic salts, water, metal-containing compounds, unsaturated monomers, polyhydric alcohols, polymeric additives, adjuvants, wetting agents, thickeners, tackifiers, oily raw materials, liquid matrices, fat-soluble substances, and polymeric carboxylates.

[0031] In one embodiment, the skin function improving composition may further contain an antiseptic, an antibacterial agent, an ultraviolet absorber, a whitening agent, vitamins and derivatives thereof, an anti-inflammatory agent, a hair growth agent, a blood circulation promoter, a stimulant, hormones, an anti-wrinkle agent, an anti-aging agent, a tightening agent, a cooling agent, a warming agent, a wound healing promoter, an irritation soothing agent, an analgesic, a cell activator, a plant / animal / microbial extract, an antipruritic agent, a keratin exfoliating / dissolving agent, an antiperspirant, a cooling agent, an enzyme, The composition may contain one or more selected from nucleic acids, astringents, fragrances, dyes, colorants, dyes, pigments, anti-inflammatory and analgesic agents, antifungals, antihistamines, hypnotics and sedatives, tranquilizers, antihypertensive agents, hypotensive diuretics, antibiotics, anesthetics, antibacterial substances, antiepileptic agents, coronary vasodilators, herbal medicines, antipruritics, keratin softening and peeling agents, ultraviolet screening agents, antiseptic and disinfecting agents, antioxidants, pH adjusters, additives, and metal soaps.

[0032] Examples of excipients that can be used include organic excipients and inorganic excipients. Examples of organic excipients that can be used include sugar derivatives such as lactose and sucrose; starch derivatives such as corn starch and potato starch; cellulose derivatives such as crystalline cellulose; and gum arabic. Examples of inorganic excipients that can be used include one or more sulfates such as calcium sulfate.

[0033] As the binder, for example, one or more selected from the above-mentioned excipients, gelatin, polyvinylpyrrolidone, and polyethylene glycol can be used.

[0034] The disintegrant may be one or more selected from the above-mentioned excipients; starch or cellulose derivatives such as croscarmellose sodium and carboxymethyl starch sodium; and cross-linked polyvinylpyrrolidone.

[0035] As the lubricant, for example, one or more selected from talc; stearic acid; colloidal silica; waxes such as beeswax and lime; sulfates such as sodium sulfate; lauryl sulfates such as sodium lauryl sulfate; and starch derivatives among the above excipients can be used.

[0036] The emulsifier can be one or more selected from the group consisting of colloidal clays such as bentonite and Veegum; anionic surfactants such as sodium lauryl sulfate; cationic surfactants such as benzalkonium chloride; nonionic surfactants such as polyoxyethylene alkyl ether; and (poly)glyceryl fatty acid ester surfactants such as polyglyceryl-10 stearate, polyglyceryl-10 distearate, polyglyceryl-10 tristearate, and polyglyceryl-10 pentastearate.

[0037] As the stabilizer, for example, one or more selected from parahydroxybenzoic acid esters such as methylparaben and propylparaben; alcohols such as chlorobutanol; and phenols such as phenol and cresol can be used.

[0038] As the diluent, for example, one or more selected from water, ethanol, and propylene glycol can be used.

[0039] Examples of oily bases include higher alcohols such as cetanol, myristyl alcohol, oleyl alcohol, lauryl alcohol, cetostearyl alcohol, stearyl alcohol, arachyl alcohol, behenyl alcohol, jojoba alcohol, chimyl alcohol, selachyl alcohol, batyl alcohol, hexyldecanol, isostearyl alcohol, 2-octyldodecanol, and dimer diol; aralkyl alcohols and derivatives such as benzyl alcohol; lauric acid, myristic acid, palmitic acid, stearic acid, and isostearyl alcohol. higher fatty acids such as hydroxystearic acid, behenic acid, undecylenic acid, 12-hydroxystearic acid, palmitoleic acid, oleic acid, linoleic acid, linolenic acid, erucic acid, docosahexaenoic acid, eicosapentaenoic acid, isohexadecanoic acid, anteisohenicosanoic acid, long-chain branched fatty acids, dimer acids, hydrogenated dimer acids, and the like, and metal soaps such as aluminum salts, calcium salts, magnesium salts, zinc salts, and potassium salts thereof, and nitrogen-containing derivatives such as amides; liquid paraffin (mineral oil), heavy liquid isoparaffin, light liquid isoparaffin, α-olefins, Hydrocarbons such as polyisobutene oligomer, polyisobutene, hydrogenated polyisobutene, polybutene, squalane, olive-derived squalane, squalene, petrolatum, and solid paraffin; waxes such as candelilla wax, carnauba wax, rice wax, Japan wax, beeswax, montan wax, ozokerite, ceresin, paraffin wax, microcrystalline wax, petrolatum, Fischer-Tropsch wax, polyethylene wax, and ethylene-propylene copolymer; coconut oil, palm oil, palm kernel oil, safflower oil, olive oil, and castor oil. Vegetable oils and fats such as shiitake oil, avocado oil, sesame oil, tea oil, evening primrose oil, wheat germ oil, macadamia nut oil, hazelnut oil, kukui nut oil, rosehip oil, meadowfoam oil, persic oil, tea tree oil, peppermint oil, corn oil, rapeseed oil, sunflower oil, wheat germ oil, linseed oil, cottonseed oil, soybean oil, peanut oil, rice bran oil, cocoa butter, shea butter, hydrogenated coconut oil, hydrogenated castor oil, jojoba oil, and hydrogenated jojoba oil; animal oils and fats such as beef tallow, milk fat, horse fat, egg yolk oil, mink oil, and turtle oil; animal waxes such as whale wax, lanolin, and orange roughy oil;Lanolins such as liquid lanolin, reduced lanolin, adsorption-purified lanolin, acetated lanolin, acetated liquid lanolin, hydroxylanolin, polyoxyethylene lanolin, lanolin fatty acids, hard lanolin fatty acids, lanolin alcohol, acetated lanolin alcohol, and cetyl lanolyl acetate esters; lecithin, phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, phosphatidylglycerol, phosphatidylinositol, sphingophospholipids such as sphingomyelin, phosphatidic acid, and lysolecithin; phospholipid derivatives such as hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, and partially hydrogenated egg yolk phospholipid; sterols such as cholesterol, dihydrocholesterol, lanosterol, dihydrolanosterol, phytosterol, and cholic acid; sapogenins; saponins; cholesteryl acetate, cholesteryl nonanoate, and cholesteryl stearate. Acyl sarcosines such as cholesteryl isostearate, cholesteryl oleate, N-lauroyl-L-glutamic acid di(cholesteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(cholesteryl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / behenyl / octyldodecyl), N-lauroyl-L-glutamic acid di(phytosteryl / octyldodecyl), and N-lauroylsarcosinate isopropyl Sterol esters such as cocin alkyl ester, cholesteryl 12-hydroxystearate, cholesteryl macadamia nut oil fatty acid, phytosteryl macadamia nut oil fatty acid, phytosteryl isostearate, cholesteryl soft lanolin fatty acid, cholesteryl hard lanolin fatty acid, cholesteryl long-chain branched fatty acid, and cholesteryl long-chain α-hydroxy fatty acid; lipid complexes such as phospholipid-cholesterol complexes and phospholipid-phytosterol complexes;Octyldodecyl myristate, hexyldecyl myristate, octyldodecyl isostearate, cetyl palmitate, octyldodecyl palmitate, cetyl octanoate, hexyldecyl octanoate, isotridecyl isononanoate, isononyl isononanoate, octyl isononanoate, isotridecyl isononanoate, isodecyl neopentanoate, isotridecyl neopentanoate, isostearyl neopentanoate, octyldodecyl neodecanoate, oleyl oleate, octyldodecyl oleate, octyldodecyl ricinoleate, octyldodecyl lanolinate, hexyldecyl dimethyloctanoate Monoalcohol carboxylic acid esters such as octyldodecyl erucate, hydrogenated castor oil isostearate, ethyl oleate, avocado oil fatty acid ethyl, isopropyl myristate, isopropyl palmitate, octyl palmitate, isopropyl isostearate, isopropyl lanolin fatty acid, diethyl sebacate, diisopropyl sebacate, dioctyl sebacate, diisopropyl adipate, dibutyloctyl sebacate, diisobutyl adipate, dioctyl succinate, and triethyl citrate; oxyacid esters such as cetyl lactate, diisostearyl malate, and hydrogenated castor oil monoisostearate;Glyceryl trioctanoate, glyceryl trioleate, glyceryl triisostearate, glyceryl diisostearate, caprylic / capric triglyceride, caprylic / capric / myristic / stearic triglyceride, hydrogenated rosin triglyceride (hydrogenated ester gum), rosin triglyceride (ester gum), glyceryl behenate eicosandioate, trimethylolpropane trioctanoate, trimethylolpropane triisostearate, diisostearate Neopentyl glycol dioctanoate, neopentyl glycol dicaprate, 2-butyl-2-ethyl-1,3-propanediol dioctanoate, propylene glycol dioleate, pentaerythrityl tetraoctanoate, hydrogenated rosin pentaerythrityl, ditrimethylolpropane triethylhexanoate, ditrimethylolpropane isostearate / sebacic acid, pentaerythrityl triethylhexanoate, dipentaerythrityl hydroxystearic acid / stearic acid / rosin acid Polyhydric alcohol fatty acid esters such as taerythrityl, diglyceryl diisostearate, polyglyceryl tetraisostearate, polyglyceryl-10 nonaisostearate, deca(erucic acid / isostearate / ricinoleic acid)polyglyceryl-8, diglyceryl (hexyldecanoate / sebacic acid) oligoester, glycol distearate (ethylene glycol distearate); diisopropyl dimer dilinoleate, diisostearyl dimer dilinoleate, dimer dilinoleate; Derivatives of dimer acid or dimer diol such as di(isostearyl / phytosteryl) dimer dilinoleate, (phytosteryl / behenyl) dimer dilinoleate, (phytosteryl / isostearyl / cetyl / stearyl / behenyl) dimer dilinoleate, dimer dilinoleyl diisostearate, dimer dilinoleyl hydrogenated rosin condensate, dimer dilinoleic acid hydrogenated castor oil, and hydroxyalkyl dimer dilinoleyl ether;Fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); dimethicone (dimethylpolysiloxane), highly polymerized dimethicone (highly polymerized dimethylpolysiloxane), cyclomethicone (cyclic dimethylsiloxane, decamethylcyclopentasiloxane), phenyl trimethicone, diphenyl dimethicone, phenyl dimethicone, stearoxypropyl dimethylamine, (aminoethylaminopropylmethicone / dimethicone) copolymer, dimethicone One or more types selected from silicones such as dimethiconol, dimethiconol crosspolymer, silicone resin, silicone rubber, amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicone, polyether-modified silicones such as dimethicone copolyol, polyglycerin-modified silicone, sugar-modified silicone, carboxylic acid-modified silicone, phosphate-modified silicone, sulfate-modified silicone, alkyl-modified silicone, fatty acid-modified silicone, alkyl ether-modified silicone, amino acid-modified silicone, peptide-modified silicone, fluorine-modified silicone, cation-modified and polyether-modified silicone, amino-modified and polyether-modified silicone, alkyl-modified and polyether-modified silicone, polysiloxane-oxyalkylene copolymer, and fluorine-based oils such as perfluorodecane, perfluorooctane, and perfluoropolyether can be used.

[0040] Examples of moisturizing agents and feel improvers include polyhydric alcohols such as glycerin, propylene glycol, 1,3-butylene glycol, sorbitol, polyglycerin, polyethylene glycol, and dipropylene glycol; NMF components such as sodium lactate, water-soluble polymers such as hyaluronic acid, collagen, mucopolysaccharides, and chondroitin sulfate; polyols and polymers thereof such as glycerin, 1,3-butylene glycol, propylene glycol, 3-methyl-1,3-butanediol, 1,3-propanediol, 2-methyl-1,3-propanediol, trimethylolpropane, pentaerythritol, hexylene glycol, diglycerin, polyglycerin, diethylene glycol, polyethylene glycol, dipropylene glycol, polypropylene glycol, and ethylene glycol-propylene glycol copolymers; glycol alkyl ethers such as diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, and diethylene glycol dibutyl ether; sorbitol sugar alcohols such as maltitol, xylitol, erythritol, mannitol, and maltitol; glucose, fructose, galactose, mannose, threose, xylose, arabinose, fucose, ribose, deoxyribose, maltose, trehalose, lactose, raffinose, gluconic acid, glucuronic acid, cyclodextrins (α-, β-, γ-cyclodextrin, and modified cyclodextrins such as maltosylated and hydroxyalkylated), β-glucan, chitin, chitosan, heparin and derivatives, pectin, alginate, Sugars and derivatives thereof, such as labinogalactan β, dextrin, dextran, glycogen, ethyl glucoside, glucosyl ethyl methacrylate polymer or copolymer; hyaluronic acid, sodium hyaluronate; sodium chondroitin sulfate; mucoitin sulfate, charonin sulfate, keratosulfate, dermatan sulfate; Tremella fuciformis extract, Tremella fuciformis polysaccharide; fucoidan; tuberose polysaccharide, naturally occurring polysaccharide; organic acids and salts thereof, such as citric acid, tartaric acid, and lactic acid; urea; 2-pyrrolidone-5-carboxylic acid and its sodium salts, etc.Amino acids and salts thereof, such as betaine (trimethylglycine), proline, hydroxyproline, arginine, lysine, serine, glycine, alanine, phenylalanine, tyrosine, β-alanine, threonine, glutamic acid, glutamine, asparagine, aspartic acid, cysteine, cystine, methionine, leucine, isoleucine, valine, tryptophan, histidine, and taurine; collagen, fish-derived collagen, atelocollagen, gelatin, elastin, collagen degradation peptides, hydrolyzed collagen, hydroxypropylammonium chloride hydrolyzed collagen, elastin degradation peptides, keratin degradation peptides, hydrolyzed keratin, conchiolin degradation peptides, hydrolyzed conchiolin, silk proteolytic peptides, hydrolyzed silk, sodium lauroyl hydrolyzed silk, soybean proteolytic peptides, wheat proteolytic peptides, hydrolyzed wheat protein, and casein Protein peptides and their derivatives, such as hydrolyzed peptides and acylated peptides; acylated peptides, such as palmitoyl oligopeptide, palmitoyl pentapeptide, and palmitoyl tetrapeptide; silylated peptides; lactic acid bacteria culture liquid, yeast extract, eggshell membrane protein, bovine submandibular gland mucin, hypotaurine, sesame lignan glycoside, glutathione, albumin, whey; choline chloride, phosphorylcholine; placenta extract, elastin, collagen, aloe extract One or more species selected from animal and plant extracts such as dandelion, hamamelis water, loofah water, chamomilla extract, licorice extract, comfrey extract, silk extract, Rosa robur extract, yarrow extract, eucalyptus extract, and melilot extract, and ceramides such as natural ceramides (types 1, 2, 3, 4, 5, and 6), hydroxyceramides, pseudoceramides, glycosphingolipids, ceramides, and glycoceramide-containing extracts can be used;

[0041] Examples of surfactants include anionic surfactants such as lauryl sulfate, polyoxyethylene alkyl ether sulfate, alkylbenzene sulfonate, polyoxyethylene alkyl ether phosphate, polyoxyethylene alkylphenyl ether phosphate, N-acylamino acid salt, sodium stearate, potassium palmitate, sodium cetyl sulfate, sodium lauryl sulfate, triethanolamine palmitate, polyoxyethylene sodium lauryl phosphate, sodium acyl glutamate, and surfactin; cationic surfactants such as benzalkonium chloride, benzethonium chloride, stearyltrimethylammonium chloride, distearyldimethylammonium chloride, and stearyldimethylbenzylammonium chloride; and amphoteric surfactants such as alkyldiaminoethylglycine hydrochloride, 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine, lauryldimethylaminoacetate betaine, and lecithin. Nonionic surfactants such as polyol fatty acid esters, glycerol monostearate, lipophilic glycerol monooleate, ethylene glycol monostearate, propylene glycol monostearate, sorbitan fatty acid esters, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene fatty acid esters, polyoxyethylene alkyl ethers, polyoxyethylene alkylphenol ethers, polyoxyethylene sorbitol fatty acid esters, N-acylamino acid esters, sucrose fatty acid esters, fatty acid alkylolamides, polyoxyethylated sterols, polyoxyethylated lanolin, and polyoxyethylene hydrogenated castor oil; fatty acid salts such as potassium laurate and potassium myristate; alkyl sulfate ester salts such as sodium lauryl sulfate, triethanolamine lauryl sulfate, and ammonium lauryl sulfate; polyoxyethylene alkyl sulfates such as sodium laureth sulfate and triethanolamine laureth sulfate;Acyl N-methyl amino acid salts such as sodium cocoyl methyl taurate, potassium cocoyl methyl taurate, sodium lauroyl methyl taurate, sodium myristoyl methyl taurate, sodium lauroyl methyl alanine, sodium lauroyl sarcosine, triethanolamine lauroyl sarcosine, and sodium lauroyl glutamate methyl alanine; acyl amino acid salts such as sodium cocoyl glutamate, triethanolamine cocoyl glutamate, sodium lauroyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, ditriethanolamine palmitoyl aspartate, and triethanolamine cocoyl alanine; polyoxyethylene alkyl ether acetates such as sodium laureth acetate; succinic acid ester salts such as sodium lauroyl monoethanolamide succinate; fatty acid alkanolamide ether carboxylates; acyl lactates; polyoxyethylene fatty amine sulfates; fatty acid alkanolamide sulfates; fatty acid glyceride sulfates such as sodium hydrogenated coconut oil fatty acid glycerin sulfate; alkylbenzene poly Oxyethylene sulfates; olefin sulfonates such as sodium α-olefin sulfonate; alkyl sulfosuccinates such as disodium lauryl sulfosuccinate and dioctyl sodium sulfosuccinate; alkyl ether sulfosuccinates such as disodium laureth sulfosuccinate, sodium monolauroyl monoethanolamide polyoxyethylene sulfosuccinate, and sodium lauryl polypropylene glycol sulfosuccinate; alkyl benzene sulfonates such as sodium tetradecylbenzene sulfonate and triethanolamine tetradecylbenzene sulfonate; alkyl naphthalene sulfonates; alkanesulfonates; α-sulfofatty acid methyl ester salts; acyl isethionates; alkyl glycidyl ether sulfonates; alkyl sulfoacetates; alkyl ether phosphate ester salts such as sodium laureth phosphate, sodium dilaureth phosphate, sodium trilaureth phosphate, and sodium monoolethphosphate; alkyl phosphate ester salts such as potassium lauryl phosphate; sodium caseinate; alkyl aryl ether phosphates; fatty acid amide ether phosphates;Phospholipids such as phosphatidylglycerol, phosphatidylinositol, and phosphatidic acid; anionic surfactants such as silicone-based anionic surfactants such as carboxylic acid-modified silicone, phosphate-modified silicone, and sulfate-modified silicone; laureths (polyoxyethylene lauryl ethers), ceteths (polyoxyethylene cetyl ethers), steareths (polyoxyethylene stearyl ethers), beheneths (polyoxyethylene behenyl ethers), isosteareths (polyoxyethylene isostearyl ethers), octyldodeceths ( Polyoxyethylene alkyl ethers with various polyoxyethylene addition numbers, such as polyoxyethylene octyldodecyl ethers; polyoxyethylene alkylphenyl ethers; castor oil and hydrogenated castor oil derivatives such as polyoxyethylene hydrogenated castor oil, polyoxyethylene castor oil, polyoxyethylene hydrogenated castor oil monoisostearate, polyoxyethylene hydrogenated castor oil triisostearate, polyoxyethylene hydrogenated castor oil monopyroglutamic acid monoisostearate diester, and polyoxyethylene hydrogenated castor oil maleic acid; polyoxyethylene phytosterols; polyoxyethylene cholesterol; polyoxyethylene cholestanol; polyoxyethylene lanolin; polyoxyethylene reduced lanolin; polyoxyethylene-polyoxypropylene cetyl ether, polyoxyethylene-polyoxypropylene 2-decyltetradecyl ether, polyoxyethylene-polyoxypropylene monobutyl ether, polyoxyethylene-polyoxypropylene hydrogenated lanolin, and polyoxyethylene-polyoxypropylene glycerin ether. pyrene alkyl ethers; polyoxyethylene polyoxypropylene glycols; (poly)glycerin polyoxypropylene glycols such as PPG-9 diglyceryl; glycerin fatty acid partial esters such as glyceryl stearate, glyceryl isostearate, glyceryl palmitate, glyceryl myristate, glyceryl oleate, glyceryl coconut oil fatty acid, glycerin monocottonseed oil fatty acid, glycerin monoerucate, glycerin sesquioleate, glycerin α,α'-oleic acid pyroglutamate, and glycerin monostearate malate;Polyglyceryl stearate-2, 3, 4, 5, 6, 8, 10, polyglyceryl distearate-6, 10, polyglyceryl tristearate-2, polyglyceryl decastearate-10, polyglyceryl isostearate-2, 3, 4, 5, 6, 8, 10, polyglyceryl diisostearate-2 (diglyceryl diisostearate), 3, 10, polyglyceryl triisostearate-2, polyglyceryl tetraisostearate, polyglyceryl decaisostearate-10, polyglyceryl oleate-2, 3, 4, 5, 6, 8, 10, polyglyceryl dioleate-6, polyglyceryl trioleate, polyglyceryl decaoleate-10, and other polyglycerin fatty acid esters; ethylene glycol monostearate ethylene glycol mono-fatty acid esters such as ethylene glycol monostearate; propylene glycol mono-fatty acid esters such as propylene glycol monostearate; pentaerythritol partial fatty acid esters; sorbitol partial fatty acid esters; maltitol partial fatty acid esters; maltitol ether; sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate, sorbitan monostearate, sorbitan sesquioleate, sorbitan trioleate, diglycerol sorbitan penta-2-ethylhexylate, and diglycerol sorbitan tetra-2-ethylhexylate; sugar derivative partial esters such as sucrose fatty acid esters, methyl glucoside fatty acid esters, and trehalose undecylenate;

[0042] Other examples include alkyl glucosides such as caprylyl glucoside; alkyl polyglycosides; lanolin alcohol; reduced lanolin; polyoxyethylene fatty acid mono- and diesters such as polyoxyethylene distearate, polyethylene glycol diisostearate, polyoxyethylene monooleate, and polyoxyethylene dioleate; polyoxyethylene propylene glycol fatty acid esters; polyoxyethylene glycerin fatty acid esters such as polyoxyethylene monooleates such as polyoxyethylene glycerin monostearate, polyoxyethylene glycerin monoisostearate, and polyoxyethylene glycerin triisostearate; polyoxyethylene sorbitan monooleate, polyoxyethylene sorbitan monostearate, polyoxyethylene sorbitan monooleate, and polyoxyethylene sorbitan tetraoleate. isosorbitan fatty acid esters; polyoxyethylene sorbitol fatty acid esters such as polyoxyethylene sorbitol monolaurate, polyoxyethylene sorbitol monooleate, polyoxyethylene sorbitol pentaoleate, and polyoxyethylene sorbitol monostearate; polyoxyethylene methyl glucoside fatty acid esters; polyoxyethylene alkyl ether fatty acid esters; polyoxyethylene animal and vegetable oils and fats such as polyoxyethylene sorbitol beeswax; alkyl glyceryl ethers such as isostearyl glyceryl ether, chimyl alcohol, selachyl alcohol, and batyl alcohol; polyhydric alcohol alkyl ethers; polyoxyethylene alkylamines; tetrapolyoxyethylene-tetrapolyoxypropylene-ethylenediamine condensates; natural surfactants such as saponin and sophorolipid; polyoxyethylene fatty acid amides;Fatty acid alkanolamides such as coconut oil fatty acid monoethanolamide (cocamide MEA), coconut oil fatty acid diethanolamide (cocamide DEA), lauric acid monoethanolamide (lauramide MEA), lauric acid diethanolamide (lauramide DEA), lauric acid monoisopropanolamide (lauramide MIPA), palmitic acid monoethanolamide (palmitamide MEA), palmitic acid diethanolamide (palmitamide DEA), coconut oil fatty acid methylethanolamide (cocamide methyl MEA); lauramine oxide, Alkyl dimethylamine oxides such as cocamine oxide, stearamine oxide, and behenamine oxide; alkyl ethoxy dimethylamine oxide; polyoxyethylene alkyl mercaptan; nonionic surfactants such as silicone-based nonionic surfactants such as polyether-modified silicones such as dimethicone copolyol, polysiloxane-oxyalkylene copolymers, polyglycerin-modified silicones, and sugar-modified silicones; cationic surfactants such as behentrimonium chloride, steartrimonium chloride, and cetrimonium chloride; Alkyltrimethylammonium chlorides such as lauryltrimonium chloride; alkyltrimethylammonium bromides such as stearyltrimonium bromide; dialkyldimethylammonium chlorides such as distearyldimonium chloride and dicocodimonium chloride; fatty acid amidoamines and salts thereof such as stearamidopropyldimethylamine and stearamidoethyldiethylamine; alkyl ether amines and salts or quaternary salts thereof such as stearoxypropyldimethylamine; fatty acid amide quaternary ammonium salts such as ethyl sulfate long-chain branched fatty acid (12-31) aminopropylethyldimethylammonium and ethyl sulfate lanolin fatty acid aminopropylethyldimethylammonium; polyoxyethylene alkylamines and salts or quaternary salts thereof; alkylamine salts; fatty acid amide guanidinium salts; alkyl ether ammonium salts; alkyltrialkylene glycol ammonium salts; benzalkonium salts; benzethonium salts; pyridinium salts such as cetylpyridinium chloride; imidazolinium salts; alkylisoquinolinium salts; dialkylmorphonium salts; polyamine fatty acid derivatives;Silicone-based cationic surfactants such as amino-modified silicones such as aminopropyl dimethicone and amodimethicone, cation-modified silicones, cation-modified and polyether-modified silicones, and amino-modified and polyether-modified silicones; N-alkyl-N,N-dimethyl amino acid betaines such as lauryl betaine (lauryl dimethyl amino acetate betaine); fatty acid amidoalkyl-N,N-dimethyl amino acid betaines such as cocamidopropyl betaine and lauramidopropyl betaine; imidazoline-type betaines such as sodium cocoamphoacetate and sodium lauroamphoacetate; alkyl sulfobetaines such as alkyldimethyltaurine; alkyldimethylamino ethoxylates; sulfate-type betaines such as alkyldimethylaminoethanol sulfate esters; phosphate-type betaines such as alkyldimethylaminoethanol phosphate esters; sphingophospholipids such as phosphatidylcholine, phosphatidylethanolamine, phosphatidylserine, and sphingomyelin, phospholipids such as lysolecithin, hydrogenated soybean phospholipid, partially hydrogenated soybean phospholipid, hydrogenated egg yolk phospholipid, partially hydrogenated egg yolk phospholipid, and hydroxide lecithin; amphoteric surfactants such as silicone-based amphoteric surfactants; polyvinyl alcohol, sodium alginate, starch derivatives, tragacanth gum, acrylic acid / alkyl methacrylate copolymers; and polymeric surfactants such as various silicone-based surfactants.

[0043] As the surfactant, for example, one or more surfactants selected from those exemplified above can be used.

[0044] Examples of polymers, thickeners, and gelling agents include guar gum, locust bean gum, queen seed, carrageenan, galactan, gum arabic, tara gum, tamarind, furcellaran, karaya gum, aoi, caragam, tragacanth gum, pectin, pectinic acid and salts such as sodium salt, alginic acid and salts such as sodium salt, mannan; starch such as rice, corn, potato, and wheat; xanthan gum, dextran, succinoglucan, curdlan, hyaluronic acid and salts thereof, xanthan gum, pullulan, gellan gum, chitin cellulose, chitosan, agar, cassou extract, chondroitin sulfate, casein, collagen, gelatin, albumin; cellulose and its derivatives such as methyl cellulose, ethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose and its sodium salts, methylhydroxypropyl cellulose, sodium cellulose sulfate, dialkyldimethylammonium cellulose sulfate, crystalline cellulose, cellulose powder; soluble starch, carboxymethyl starch, methylhydroxypropyl starch, methyl starch-based polymers such as ethyl starch, starch derivatives such as hydroxypropyltrimonium starch chloride, corn starch aluminum octenylsuccinate, etc.; alginic acid derivatives such as sodium alginate and propylene glycol alginate; polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), vinylpyrrolidone-vinyl alcohol copolymer, polyvinyl methyl ether; polyethylene glycol, polypropylene glycol, polyoxyethylene-polyoxypropylene copolymer; amphoteric methacrylate ester copolymers such as (methacryloyloxyethyl carboxybetaine / alkyl methacrylate) copolymer, (acrylates / stearyl acrylate / ethylamine oxide methacrylate) copolymer; (dimethicone / vinyl dimethicone) crosspolymer, (alkyl acrylate / diacetone acrylamide) copolymer, (alkyl acrylate / diacetone acrylamide) copolymer AMP; partially saponified polyvinyl acetate, maleic acid copolymer; vinylpyrrolidone-dialkylaminoalkyl methacrylate copolymer; acrylic resin alkanolamine;Polyester, water-dispersible polyester; polyacrylamide; polyacrylic acid ester copolymers such as polyethyl acrylate, carboxyvinyl polymers, polyacrylic acid and its salts such as sodium salt, acrylic acid-methacrylic acid ester copolymers; acrylic acid-alkyl methacrylate copolymers; cationized cellulose such as Polyquaternium-10, diallyldimethylammonium chloride-acrylamide copolymers such as Polyquaternium-7, acrylic acid-diallyldimethylammonium chloride copolymers such as Polyquaternium-22, acrylic acid-diallyldimethylammonium chloride-acrylamide copolymers such as Polyquaternium-39, acrylic acid-cationized methacrylic acid ester copolymers, acrylic acid-cationized methacrylic acid amide copolymers, acrylic acid-methyl acrylate-methacrylamidopropyltrimethylammonium chloride copolymers such as Polyquaternium-47, methacrylic acid chloride choline ester polymers; cationized cellulose cationized polysaccharides such as oligosaccharides, cationized dextran, and guar hydroxypropyltrimonium chloride; polyethyleneimine; cationic polymers; 2-methacryloyloxyethyl phosphorylcholine polymers such as polyquaternium-51 and copolymers with butyl methacrylate copolymers and the like; polymer emulsions such as acrylic resin emulsions, polyethyl acrylate emulsions, polyacrylic alkyl ester emulsions, polyvinyl acetate resin emulsions, natural rubber latex, and synthetic latex; nitrocellulose; polyurethanes and various copolymers; various silicones; various silicone-based copolymers such as acrylic-silicone graft copolymers; various fluorine-based polymers; 12-hydroxystearic acid and its salts; dextrin fatty acid esters such as dextrin palmitate, dextrin stearate, and dextrin 2-ethylhexanoic acid palmitate; dextrin fatty acid esters such as dextrin myristate;One or more selected from anhydrous silicic acid, fumed silica (ultrafine particle anhydrous silicic acid), aluminum magnesium silicate, sodium magnesium silicate, metal soap, dialkyl phosphate metal salt, organically modified clay minerals such as bentonite, hectorite, dimethylbenzyldodecylammonium montmorillonite clay, and dimethyldioctadecylammonium montmorillonite clay, sucrose fatty acid esters such as sucrose palmitate and sucrose stearate, amino acid derivatives such as N-lauroyl-L-glutamic acid and α,γ-di-n-butylamine, benzylidene derivatives of sorbitol such as monobenzylidene sorbitol and dibenzylidene sorbitol, and fructooligosaccharide fatty acid esters can be used;

[0045] Examples of solvents and propellants include monohydric alcohols such as methanol, ethanol, propanol, benzyl alcohol, phenethyl alcohol, isopropyl alcohol, isobutyl alcohol, hexyl alcohol, 2-ethylhexanol, cyclohexanol, octyl alcohol, butanol, and pentanol; ketones such as acetone and methyl ethyl ketone; lower alcohols such as ethanol, 2-propanol (isopropyl alcohol), butanol, and isobutyl alcohol; glycols such as propylene glycol, 1,3-butylene glycol, diethylene glycol, dipropylene glycol, and isopentyl diol; diethylene glycol monoethyl ether (ethoxydiglycol), ethylene glycol monoethyl ether, ethylene glycol monobutyl ether, triethylene glycol monoethyl ether, and diethylene glycol monoethyl ether. One or more solvents selected from the group consisting of glycol ethers such as glycol diethyl ether, diethylene glycol dibutyl ether, propylene glycol monoethyl ether, and dipropylene glycol monoethyl ether; glycol ether esters such as ethylene glycol monoethyl ether acetate, diethylene glycol monoethyl ether acetate, and propylene glycol monoethyl ether acetate; glycol esters such as diethoxyethyl succinate and ethylene glycol disuccinate; benzyl alcohol, benzyloxyethanol, propylene carbonate, dialkyl carbonate, acetone, ethyl acetate, N-methylpyrrolidone; toluene; fluorocarbons, next-generation chlorofluorocarbons; LPG, dimethyl ether, carbon dioxide, cellosolve, dioxane, dimethylformamide, dimethyl sulfoxide, and crotamiton can be used.

[0046] Examples of antioxidants, reducing agents, and oxidizing agents include tocopherol (vitamin E), tocopherol derivatives such as tocopherol acetate, BHT, BHA, gallic acid derivatives such as propyl gallate, vitamin C (ascorbic acid) and / or derivatives thereof, erythorbic acid and derivatives thereof, sulfites such as sodium sulfite, bisulfites such as sodium bisulfite, thiosulfates such as sodium thiosulfate, metabisulfites, thiotaurine, hypotaurine, thioglycerol, thiourea, thioglycolic acid, cysteine ​​hydrochloride, thioglycolic acid, cysteine, cysteamine, hydrogen peroxide, ammonium persulfate, sodium bromate, percarbonate, nordihydroguaiaretic acid, guaiac oil, butylhydroxyanisole, dibutylhydroxytoluene (BHT), and 2,2'-methylenebis(4-methyl-6-t-butyl)phenol. One or more of these can be used.

[0047] Examples of preservatives, antibacterial agents, and chelating agents include hydroxybenzoic acids and salts or esters thereof, such as methylparaben, ethylparaben, propylparaben, and butylparaben; salicylic acid; sodium benzoate; phenoxyethanol; 1,2-diols, such as 1,2-pentanediol and 1,2-hexanediol; isothiazolinone derivatives, such as methylchloroisothiazolinone and methylisothiazolinone; imidazolinium urea; dehydroacetic acid and its salts; phenols; halogenated bisphenols, such as triclosan, acid amides, and quaternary ammonium salts; trichlorocarbanilide, zinc pyrithione, benzalkonium chloride, benzethonium chloride, sorbic acid, chlorhexidine, chlorhexidine gluconate, halocarban, hexachlorophene, hinokitiol; phenol, isopropylphenol, cresol, thymo hydroxyethylethylenediaminetriacetate such as EDTA 3Na; pentetate (diethylenetriaminepentaacetate); phytic acid; phosphonic acids such as etidronic acid and salts thereof such as sodium salts; sodium oxalate; polyamino acids such as polyaspartic acid and polyglutamic acid; sodium polyphosphate, sodium metaphosphate, phosphoric acid; sodium citrate, citric acid, alanine, dihydroxyethylglycine, gluconic acid, ascorbic acid, succinic acid, tartaric acid, pyrophosphate, and hexametaphosphate.

[0048] Examples of pH adjusters, acids, and alkalis include alkali metal hydroxides, alkaline earth metal hydroxides, primary, secondary, or secondary alkali metal hydroxides such as sodium hydroxide, potassium hydroxide, calcium hydroxide, magnesium hydroxide, 2-amino-2-methyl-1,3-propanediol, 2-amino-2-hydroxymethyl-1,3-propanediol, arginine, guanidine carbonate, ammonium carbonate, ammonia, aqueous ammonia, triethanolamine, dimethylamine, diethylamine, trimethylamine, triethylamine, triisopropanolamine, trisodium phosphate, disodium hydrogen phosphate, dipotassium hydrogen phosphate, monoethanolamine, diethanolamine, isopropanolamine, diisopropanolamine, and polyethanolamine. One or more selected from alkalis such as tertiary alkylamines or primary, secondary or tertiary alkanolamines, acids such as citric acid, tartaric acid, lactic acid, glycolic acid, hydrochloric acid, nitric acid, citric acid, sodium citrate, sodium lactate, succinic acid, acetic acid, sodium acetate, fumaric acid, sulfuric acid, malic acid and phosphoric acid, and polymers exhibiting acidic or alkaline properties such as alginic acid, polyglutamic acid, polyaspartic acid, starch-acrylic acid graft polymers, polyacrylic acid, polyvinyl acetate-crotonic acid copolymers, vinyl acetate-(meth)acrylic acid copolymers, vinyl acetate-crotonic acid copolymers, polyvinyl sulfonic acid, polyitaconic acid, styrene-maleic anhydride copolymers and acrylamide-acrylic acid copolymers can be used.

[0049] Examples of powders and inorganic salts include mica, talc, kaolin, sericite, montmorillonite, kaolinite, mica, muscovite, phlogopite, synthetic mica, lepidolite, biotite, vermiculite, magnesium carbonate, calcium carbonate, aluminum silicate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, tungstate metal salts, magnesium, zeolite, barium sulfate, calcined calcium sulfate, calcium phosphate, fluorapatite, hydroxyapatite, ceramic powder, bentonite, smectite, Inorganic powders of various sizes and shapes, such as tungsten, clay, mud, metal soaps (for example, zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, iron blue, carbon black, titanium oxide, fine and ultrafine titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silicic anhydride), titanium mica, fish scale foil, boron nitride, photochromic pigments, synthetic fluorine phlogopite, fine composite powder, gold, aluminum, etc., and inorganic powders of various sizes and shapes, such as tungsten, clay, mud, metal soaps (for example, zinc myristate, calcium palmitate, aluminum stearate), calcium carbonate, red iron oxide, yellow iron oxide, black iron oxide, ultramarine, iron blue, carbon black, titanium oxide, fine and ultrafine titanium oxide, zinc oxide, fine and ultrafine zinc oxide, alumina, silica, fumed silica (ultrafine silicic anhydride), titanium mica, fish scale foil, boron nitride, photochromic pigments, synthetic fluorine phlogopite, fine composite powder, gold, aluminum, etc., and those which are hydrogenated Inorganic powders such as powders that have been hydrophobized or hydrophilized by treatment with various surface treatment agents such as silicones such as silanes or cyclic hydrogen silicones, or other silanes or titanium coupling agents; organic powders and surface-treated powders of various sizes and shapes, such as starch, cellulose, nylon powder, polyethylene powder, polymethyl methacrylate powder, polystyrene powder, styrene-acrylic acid copolymer resin powder, polyester powder, benzoguanamine resin powder, polyethylene terephthalate-polymethyl methacrylate laminated powder, polyethylene terephthalate-aluminum-epoxy laminated powder, urethane powder, silicone powder, Teflon (registered trademark) powder, etc.; sodium chloride-containing salts such as table salt, ordinary salt, rock salt, sea salt, and natural salt; potassium chloride, aluminum chloride, calcium chloride, magnesium chloride, bittern, zinc chloride, ammonium chloride; sodium sulfate, aluminum sulfate, aluminum-potassium sulfate (alum), aluminum-ammonium sulfate, barium sulfate, calcium sulfate, potassium sulfate, magnesium sulfate, zinc sulfate, iron sulfate, and copper sulfate;Sodium phosphates such as monosodium, disodium, and trisodium phosphate, potassium phosphates, calcium phosphates, magnesium phosphates, magnesium oxide, lithia mica, silicic acid, aluminum magnesium silicate, vermiculite, higilite, ceramic powder, dicalcium phosphate, aluminum hydroxide, boron nitride, and the like; organic powders such as polyamide powder, polyester powder, polyethylene powder, polypropylene powder, polystyrene powder, polyurethane, benzoguanamine powder, polymethylbenzoguanamine powder, tetrafluoroethylene powder, polymethyl methacrylate powder, silk powder, nylon powder, nylon 12, nylon 6, styrene-acrylic acid copolymer, divinylbenzene-styrene copolymer, vinyl resin, urea resin, phenolic resin, fluororesin, silicon resin, acrylic resin, melamine resin, epoxy resin, polycarbonate resin, microcrystalline fiber powder, lauroyl lysine, and the like; colored pigments such as inorganic red pigments of iron oxide, iron hydroxide, and iron titanate, inorganic brown pigments such as gamma-iron oxide, inorganic yellow pigments such as yellow iron oxide and yellow ochre, black iron oxide, and kaolin. inorganic black pigments such as carbon black, inorganic purple pigments such as manganese violet and cobalt violet, inorganic green pigments such as chromium hydroxide, chromium oxide, cobalt oxide and cobalt titanate, inorganic blue pigments such as Prussian blue and ultramarine, lakes of tar-based pigments, lakes of natural pigments, and composite powders of these powders; pearl pigments such as titanium oxide-coated mica, titanium oxide-coated mica, bismuth oxychloride, titanium oxide-coated bismuth oxychloride, titanium oxide-coated talc, fish scale foil, and titanium oxide-coated colored mica; aluminum powder, copper powder, metal powder pigments such as black tar and stainless steel powder; tar dyes such as Red No. 3, Red No. 104, Red No. 106, Red No. 201, Red No. 202, Red No. 204, Red No. 205, Red No. 220, Red No. 226, Red No. 227, Red No. 228, Red No. 230, Red No. 401, Red No. 505, Yellow No. 4, Yellow No. 5, Yellow No. 202, Yellow No. 203, Yellow No. 204, Yellow No. 401, Blue No. 1, Blue No. 2, Blue 201, Blue No. 404, Green No. 3, Green 201, Green No. 204, Green No. 205, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 206, and Orange No. 207;One or more of the following may be used: powders selected from natural pigments such as carminic acid, laccaic acid, carthamine, brazilian, and crocin, which are composites of these powders or have been surface-treated with oils, silicones, or fluorine compounds; montmorillonite, silicic anhydride, gypsum, diatomaceous earth, calcium carbonate, hydrotalcite, talc, glass, kaolin, metal soap, aerosil, bismuth oxychloride, fish scale foil, zinc oxide, and titanium dioxide;

[0050] As the water, for example, one or more types selected from tap water, purified water, hard water, soft water, natural water, deep sea water, electrolytic alkaline ionized water, electrolytic acidic ionized water, ionized water, and cluster water can be used.

[0051] Examples of metal-containing compounds include lithium oxide, butyl lithium, ethyl lithium, lithium bromide, lithium carbide, lithium iodide, lithium nitrate, lithium nitride, lithium sulfide, methyl lithium, lithium sulfate, lithium chloride, lithium hydride, propyl lithium, lithium carbonate, lithium fluoride, lithium niobate, lithium peroxide, lithium hydroxide, lithium molybdate, lithium perchlorate, lithium acetate, lithium formate, lithium tungstate, lithium hypochlorite, lithium acetate dihydrate, lithium iodide dihydrate, and lithium hydrogen sulfate. Lithium compounds such as lithium acetate dihydrate, lithium bromide monohydrate, lithium sulfate monohydrate, dilithium carbonate, dilithium oxalate, dilithium sulfate, lithium chromate dihydrate, lithium hydroxide monohydrate, lithium citrate tetrahydrate, lithium perchlorate trihydrate, and lithium hexafluorophosphate, sodium amide, sodium oxide, sodium azide, sodium acetate, sodium acetylide, sodium bromide, sodium formate, sodium iodide, sodium lactate, sodium methoxide, sodium nitrate, sodium sulfate, sodium sulfide, and boric acid Sodium, metallic sodium, sodium bromate, sodium chloride, sodium hydride, sodium nitrite, sodium sulfite, sodium iodate, sodium phosphate, ecabet sodium, sodium butyrate, sodium heparin, sodium chlorate, sodium citrate, sodium cyanate, sodium cyanide, sodium fluoride, sodium oleate, sodium oxalate, sodium peroxide, sodium silicate, sodium stannate, sodium-t-butoxide, sodium carbonate, suramin sodium, sodium benzoate, sodium chlorite, sodium chromate, sodium hydroxide, sodium selenate, sodium selenide, sodium laurate, disodium inosinate (hereinafter abbreviated as IMP), sodium alginate, sodium perborate, sodium persulfate, sodium phosphite, sodium rhodanide, disodium arsenate, sodium selenite, amfenac sodium, tolmetin sodium, sodium pyruvate, saccharin sodium, sodium aluminate, sodium gluconate, sodium polysulfide, sodium stearate, sodium valproate,Iopodate sodium, sodium bicarbonate, disodium carbonate, sodium periodate, reviparin sodium, porfimer sodium, carumonam sodium, cefminox sodium, flomoxef sodium, cephalothin sodium, cefazolin sodium, latamoxef sodium, sodium glutamate, sodium molybdate, sodium percarbonate, sodium perchlorate, sodium salicylate, sodium thiosulfate, thiamylal sodium, triclofos sodium, sodium bicarbonate, sodium dichromate, sodium dichromate Thorium, sodium fluoroborate, sodium acid sulfide, disodium phosphate, beraprost sodium, cefotetan sodium, ceftezole sodium, faropenem sodium, trisodium citrate, cephapirin sodium, ampicillin sodium, cefoxitin sodium, cefsulodin sodium, cefuroxime sodium, dantrolene sodium, sodium antimonate, sodium dithionite, sodium propionate, sodium tungstate, sodium metabisulfite, trisodium phosphate, sodium triphosphate, dal Teparin sodium, Parnaparin sodium, Danaparoid sodium, Cefodizime sodium, Carmellose sodium, Iothalamate sodium, Foscarnet sodium, Sodium metabisulfite, Cefotaxime sodium, Cefpiramide sodium, Cyclamate sodium, Diclofenac sodium, Sodium borohydride, Sodium hypochlorite, Sodium thiocyanate, Thiopental sodium, Ticarcillin sodium, Fosfomycin sodium, Sodium arsenate, Dibasic sodium hypophosphinate, Sodium hyaluronate , imitrodast sodium, bucladesine sodium, sodium boron hydroxide, sodium glucuronate, sodium aluminum sulfate, cefmetazole sodium, ceftizoxime sodium, cloxacillin sodium, sodium cyclamate, fluorescein sodium, liothyronine sodium, loxoprofen sodium, piperacillin sodium, sodium hydrosulfite, sodium hypophosphite, sodium naphthionate, sodium permanganate, sodium pyrophosphate, fluvastatin sodium, pravastatin sodium,Rabeprazole sodium, sodium methacrylate, 5'-IMP disodium, amobarbital sodium, cefamandole sodium, cefoperazone sodium, sodium ferrocyanide, sodium hydrogen sulfide, sodium metavanadate, sodium silicofluoride, sodium xanthogenate, sodium fluoroacetate, sodium lauryl sulfate, sodium cromoglycate, sodium picosulfate, sodium fluoroacetate, sodium metabisulfite, sodium taurocholate, cerivastatin sodium, sodium acetate trihydrate, ceftriaxone sodium sodium, carbenicillin sodium, cefbuperazone sodium, monosodium fumarate, levothyroxine sodium, sodium dehydroacetate, sodium bisulfite, sulbenicillin sodium, sodium borate decahydrate, sodium metavanadate, sodium metaperiodate, sodium cholate hydrate, sodium sulfate decahydrate, sodium dodecyl sulfate, secobarbital sodium, lobenzarit disodium, sodium deoxycholate, sodium nitroprusside, dicloxacillin sodium, sodium phthalocyanine, sodium thioglycolate, Disodium sulfate, sodium dihydronaphthalenidyl, sodium gold thiomalate, 2-biphenylol sodium, sodium cholate n-hydrate, sodium stannate trihydrate, sodium sulfide nonahydrate, calcium disodium edetate, epoprostenol sodium, sodium ferrous citrate, anhydrous sodium carbonate, sodium sulfite heptahydrate, sodium silicoaluminate, sodium caffeine benzoate, disodium hydrogen arsenate, sodium saccharin dihydrate, dibasic sodium phosphate, sodium trichloroacetate um, sodium tripolyphosphate, sodium peroxodisulfate, bromfenac sodium hydrate, sodium molybdate dihydrate, basic sodium phosphate, tribasic sodium phosphate, sodium trifluoroacetate, tetrasodium pyrophosphate, sodium chromate tetrahydrate, sodium succinate hexahydrate, sodium dihydrogen citrate, sodium stearyl fumarate, antimony sodium tartrate, sodium cyanoborohydride, sodium dihydrogen phosphate, prasterone sodium sulfate, sodium selenite pentahydrate,Dipicrylamine sodium, sodium hexametaphosphate, sodium perborate tetrahydrate, sodium tetrahydroborate, sodium acyl-β-alanine, disodium hydrogen phosphate, sodium perchlorate monohydrate, (+)-sodium pantothenate, sodium metasilicate (anhydrous), sodium tetrafluoroborate, sodium sulfanilate dihydrate, sodium cellulose sulfate, pantoprazole sodium hydrate, sodium chondroitin sulfate, disodium methylarsonate, sodium hexafluorosilicate, riboflavin phosphate Sodium thorium, dextran sulfate sodium sulfur, trisodium phosphate dodecahydrate, 5'-guanylate disodium, 5'-inosinate disodium, dextran sulfate sodium sulfur-18, sulfobromophthalein sodium, 5'-cytidylate disodium, lauryl sulfonate sodium salt, betamethasone sodium phosphate, sodium polystyrene sulfonate, prednisolone sodium phosphate, pentachlorophenol sodium salt, dichloroisocyanuric acid sodium salt, dexamethasone sodium phosphate, estramustine sodium phosphate , prednisolone sodium succinate, sodium hydrogen fumarate, sodium hexacyanoferrate(II), sodium 1-dodecanesulfonate, sodium dihydrogen phosphate dihydrate, carbazochrome sodium sulfonate, hydrocortisone sodium phosphate, sodium 2-hydroxypropanoate, sodium pyrophosphate decahydrate, disodium dihydrogen pyrophosphate, sodium triacetoxyborohydride, hydrocortisone sodium succinate, dibasic sodium phosphate dodecahydrate, colistin sodium methanesulfonate, dodecylbenzenesulfonate sodium benzoate, chloramphenicol sodium succinate, sodium 2-hydroxypropionate, sodium (Z)-9-octadecenoate, disodium 2-hydroxysuccinate, sodium cyclohexylsulfamate, sodium flavin adenine dinucleotide, uridine-5'-diphosphate disodium, sodium diphenylamine-4-sulfonate, methylprednisolone sodium succinate, inosine 5'-monophosphate sodium salt, inosine-5'-phosphate disodium, sodium N-cyclohexylsulfamate,Cytidine 5'-phosphate disodium, guanosine 5'-phosphate disodium, (E)-2-butenedioic acid monosodium salt, dexamethasone sodium metasulfobenzoate, 2,4-dichlorophenoxyacetic acid sodium salt, (2,4-dichlorophenoxy) sodium acetate, 1,5-naphthalenedisulfonic acid disodium, pentachlorophenol, sodium salt (technical grade), sodium 4-(2,4-dichloro-m-toluoyl)-1,3-dimethylpyrazol-5-olate, 2-methyl-4-chlorophenoxyacetic acid sodium, (4-chloro-2-methylphenoxy) acetate sodium, [(4-chloro-2-methylphenyl)oxy] acetate sodium, hydrogenated coconut oil fatty acid glycerin sodium sulfate, sodium 5-ethyl-5,8-dihydro-8-oxofuro[3,2-b][1,8]naphthyridine-7-carboxylate, 2-hydroxy-1,2,3-propanetricarboxylic acid trisodium salt, Disodium 1-phenylazo-2-naphthol-4',6-disulfonate, sodium 1-(p-sodiosulfophenylazo)-2-hydroxynaphthalene-6-sulfonate, disodium 6-hydroxy-5-[(4-sulfophenyl)azo]-2-naphthalenesulfonate, trisodium 2-hydroxy(1,1'-azobisnaphthalene)-3,4',6-trisulfonate, (+)-N-[(R)-2,4-dihydroxy-3,3-dimethylbutyric acid sodium compounds such as sodium [(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)amino]methanesulfonate, sodium (+)-3-[[(R)-2,4-dihydroxy-3,3-dimethylbutyryl]amino]propionate, and sodium [methyl(2,3-dihydro-1,5-dimethyl-3-oxo-2-phenyl-1H-pyrazol-4-yl)amino]methanesulfonate.

[0052] Other examples include potassium alum, potassium oxide, potassium bromide, potassium iodide, potassium nitrate, potassium sulfate, potassium sulfide, potassium acetate, potassium bromate, potassium chloride, potassium nitrite, potassium sulfite, potassium arsenate, potassium iodate, potassium hydride, potassium t-butoxide, potassium carbonate, potassium chlorate, potassium cyanate, potassium cyanide, potassium fluoride, potassium oxalate, potassium silicate, potassium arsenite, potassium stannate, potassium chromate, potassium hydroxide, potassium phosphate, potassium sorbate, and potassium bisulfate. , potassium selenate, potassium persulfate, potassium rhodanide, losartan potassium, potassium selenite, potassium tellurite, warfarin potassium, potassium periodate, potassium gluconate, potassium canrenoate, potassium perchlorate, potassium thiosulfate, potassium dichromate, potassium fluoroborate, potassium dichromate, potassium molybdate, potassium pyrosulfite, potassium aspartate, pemirolast potassium, potassium hypochlorite, potassium thiocyanate, potassium clavulanate, potassium aluminum sulfate, potassium cyanide, hydroxide Potassium borate, potassium hypophosphite, potassium metaphosphate, potassium permanganate, potassium pyrophosphate, potassium ferricyanide, potassium ferrocyanide, potassium silicofluoride, potassium hydrogen sulfate, potassium metavanadate, potassium xanthate, potassium hydrogen oxalate, dipotassium clorazepate, potassium selenocyanate, dipotassium oxalate, potassium fluorosilicate, potassium stannate trihydrate, potassium bicarbonate, potassium peroxodisulfate, potassium aluminum sulfate, tetrapotassium pyrophosphate, potassium benzylpenicillin, potassium Potassium compounds such as (methylsulfinyl)methanide, potassium dihydrogen phosphate, dipotassium hydrogen phosphate, dipotassium glycyrrhizinate, potassium tetrafluoroborate, potassium guaiacolsulfonate, potassium hexafluorosilicate, potassium aluminum sulfate dodecahydrate, potassium o-ethyl dithiocarbonate, potassium hexacyanoferrate(III), potassium phenoxymethylpenicillin, and potassium (2E,4E)-2,4-hexadienoate, rubidium oxide, rubidium bromide, rubidium iodide, rubidium sulfate, rubidium chloride, and rubidium fluoride,Rubidium compounds such as rubidium acetate, rubidium hydrogen sulfate, and rubidium carbonate; cesium compounds such as cesium cyanide, cesium oxide, cesium bromide, cesium iodide, cesium nitrate, cesium sulfate, cesium chloride, cesium carbonate, cesium fluoride, dicesium carbonate, dicesium oxalate, dicesium sulfate, dicesium L-tartrate, cesium hydroxide monohydrate, cesium trifluoroacetate, 1-cesium 2,3-dihydroxybutanedioate, and 1-cesium hydrogen 2,3-dihydroxybutanedioate; beryllium oxide, beryllium bromide, beryllium carbide, and beryllium iodide. Beryllium compounds such as beryllium, beryllium nitrate, beryllium nitride, beryllium sulfide, beryllium chloride, beryllium fluoride, beryllium silicate, beryllium distearate, beryllium sulfate tetrahydrate, and acetylacetonate beryllium salts, magnesium oxide, magnesium orotate, aryl magnesium, magnesium acetate, magnesium boride, magnesium bromide, magnesium carbide, magnesium iodide, magnesium nitrate, magnesium nitride, magnesium sulfate, magnesium sulfide, magnesium (powder), magnesium chloride, magnesium carbonate, and chlorine. magnesium compounds such as magnesium hydroxide, magnesium citrate, magnesium fluoride, magnesium silicate, magnesium silicide, magnesium hydroxide, magnesium phosphide, magnesium orotate, magnesium (II) nitrate, magnesium stearate, magnesium perchlorate, magnesium myristate, magnesium oxalate, magnesium bicarbonate, magnesium silicofluoride, magnesium fluorosilicate, phenylmagnesium bromide, magnesium nitrate hexahydrate, magnesium phthalocyanine, magnesium acetate tetrahydrate, magnesium benzoate trihydrate, calcium magnesium carbonate, magnesium chromate pentahydrate, magnesium hexafluorosilicate, magnesium aluminometasilicate, magnesium aluminosilicate bismuth, and aluminum magnesium hydroxide carbonate hydrate; calcium carbide, calcium oxide, calcium bromide, calcium carbide, calcium cyanamide, calcium iodide, calcium lactate, calcium nitrate, calcium nitride, calcium sulfate, calcium sulfide, calcium acetate, calcium chloride, calcium nitrite, calcium sulfite, and calcium arsenate;Calcium hydride, calcium arsenate, calcium iodate, calcium carbonate, calcium chlorate, calcium fluoride, calcium oxalate, calcium peroxide, calcium silicate, calcium silicate, calcium cyanide, calcium arsenite, calcium heparin, calcium chlorite, calcium chromate, calcium hydroxide, calcium phosphate, calcium phosphite, calcium folinate, calcium gluconate, calcium stearate, calcium aspartate, calcium hypochlorite, fosfomycin calcium, calcium metasilicate, calcium thiocyanate, calcium hypophosphite, calcium pantothenate, calcium permanganate, fenoprofen calcium, calcium chloride dihydrate, calcium magnesium carbonate, calcium polycarbophil, mupirocin calcium hydrate, calcium hydrogen phosphate, calcium glycerophosphate, calcium diiodostearate, precipitated calcium carbonate, calcium edetate disodium, atorvastatin calcium hydrate, (+)-calcium pantothenate, calcium para-aminosalicylate, calcium tocopheryl succinate calcium compounds such as calcium carbonate, calcium polystyrene sulfonate, (+)-pantothenic acid calcium salt (2:1), calcium alumino-para-aminosalicylate, 3-hydroxy-4-[(4-methyl-2-sulfophenyl)azo]-2-naphthalenecarboxylic acid calcium salt, barium oxide, barium azide, barium acetate, barium bromide, barium iodide, barium nitrate, barium nitride, barium sulfate, barium sulfide, barium formate, barium lactate, barium chloride, barium sulfite, barium carbonate, barium chlorate, barium fluoride, barium peroxide, Barium cyanide, barium chromate, barium hydroxide, barium titanate, barium selenate, barium phosphate, barium(II) nitrate, barium selenite, barium manganate, barium oxalate, barium stearate, barium perchlorate, barium thiosulfate, barium hypochlorite, barium permanganate, barium chloranilate, barium chloride dihydrate, barium diacetate, barium bromide dihydrate, barium dipropionate, barium chlorate monohydrate, barium hydroxide octahydrate, barium thiocyanate dihydrate, barium thiosulfate monohydrate,Examples of barium compounds include barium acetylacetonate dihydrate.

[0053] As the metal-containing compound, one or more compounds selected from the compounds described above can be used.

[0054] Examples of the unsaturated monomer include acrylic acid polymers, maleic acid, maleic anhydride, fumaric acid, crotonic acid, itaconic acid, vinyl sulfonic acid, styrene sulfonic acid, 2-(meth)acrylamide-2-methylpropanesulfonic acid, 2-(meth)acryloylethanesulfonic acid, and 2-(meth)acryloylpropanesulfonic acid, as well as acid group-containing hydrophilic unsaturated monomers and salts thereof; N-vinylacetamide, N-methyl-N-vinylacetamide, acrylamide, methacrylamide, N-ethyl(meth)acrylamide, N-n-propyl(meth)acrylamide, N-isopropyl(meth)acrylamide, N,N-dimethyl(meth)acrylamide, 2-hydroxyethyl(meth)acrylate, 2-hydroxypropyl(meth)acrylamide, and the like. One or more compounds selected from the group consisting of nonionic hydrophilic unsaturated monomers such as N,N-dimethylaminoethyl (meth)acrylate, methoxypolyethylene glycol (meth)acrylate, polyethylene glycol mono(meth)acrylate, vinylpyridine, N-vinylpyrrolidone, N-acryloylpiperidine, and N-acryloylpyrrolidine; cationic hydrophilic unsaturated monomers such as N,N-dimethylaminoethyl (meth)acrylate, N,N-diethylaminoethyl (meth)acrylate, N,N-dimethylaminopropyl (meth)acrylate, and N,N-dimethylaminopropyl (meth)acrylamide and quaternary salts thereof, styrene, vinyl chloride, butadiene, isobutene, ethylene, propylene, stearyl (meth)acrylate, and lauryl (meth)acrylate can be used.

[0055] Examples of polyhydric alcohols that can be used include ethylene glycol, propylene glycol, 1,3-butylene glycol, ethylene glycol monobutyl ether, diethylene glycol, triethylene glycol, 1,4-butylene glycol (dihydric alcohol), glycerin, trioxyisobutane (trihydric alcohol), erythritol, pentaerythritol (tetrahydric alcohol), xylitol, adonite (pentahydric alcohol), allodulcite, sorbitol, sorbitol liquid, mannitol (hexahydric alcohol), polyglycerin, and one or more selected from dipropylene glycol.

[0056] Examples of the polymer additive that can be used include one or more selected from polyvinylpyrrolidone, carboxyvinyl polymers which are crosslinked polyacrylic acids, vinylpyrrolidone-ethyl acrylate copolymers, N-vinylacetamide copolymers such as N-vinylacetamide-sodium acrylate copolymers, N-vinylacetamide homopolymers, polyvinylsulfonic acid, N-vinylacetamide crosslinked products, polyitaconic acid, hydroxypropyl cellulose, and hydroxypropyl methylcellulose.

[0057] Examples of adjuvants include keratin softeners such as ethyl alcohol, isopropyl alcohol, butanol, 1,3-butanediol, propylene glycol, polyethylene glycol #400, glycerin, crotamiton, benzyl alcohol, phenylethyl alcohol, propylene carbonate, hexyldodecanol, propanol, salicylic acid, allantoin, dimethyl sulfoxide, dimethylacetamide, dimethylformamide, diisopropyl adipate, diethyl sebacate, ethyl laurate, lanolin, Azone, 1-geranylazacyloheptan-2-one (GACH), fatty acid dialkylolamide, salicylic acid, salicylic acid derivatives, urea, and sulfur; moisturizers such as pyrrolidone carboxylic acid; surfactants such as propylene glycol monooleate, polyoxyethylene sorbitan monostearate, sorbitan monostearate, and glycerin monostearate; esters such as isopropyl myristate and diethyl sebacate; oleyl alcohol, stearyl alcohol, and lauric acid. higher alcohols such as ethyl alcohol, fatty acids such as stearic acid, hexanoic acid, nonanoic acid, decanoic acid, dodecanoic acid, tetradecanoic acid, hexadecanoic acid, octadecanoic acid, oleic acid, and linoleic acid, terpene compounds and surfactants such as menthol, menthone, limonene, pinene, piperitone, terpinene, terpinolene, terpinolol, and carveol, allantoin, dimethyl sulfoxide, dimethylacetamide, dimethylformamide, diisopropyl adipate, and diethyl sebacate, One or more additives selected from the group consisting of auxiliaries such as ethyl laurate, lanolin, and Azone, and, if necessary, refreshing agents such as menthol and camphor, oil components such as almond oil, olive oil, camellia oil, persic oil, peppermint oil, sesame oil, soybean oil, mink oil, cottonseed oil, corn oil, safflower oil, coconut oil, eucalyptus oil, castor oil, liquid paraffin, petrolatum, squalene, squalane, and lanolin, gelling agents such as carboxyvinyl polymers, and neutralizing agents such as diisopropanolamine can be used.

[0058] As the humectant, for example, one or more selected from glycerin, propylene glycol, sorbitol, 1,3-butylene glycol, dl-pyrrolidonecarboxylic acid, and sodium lactate can be used.

[0059] Examples of thickeners include gum arabic, tragacanth gum, locust bean gum, guar gum, echo gum, karaya gum, agar, starch, carrageenan, alginic acid, alginates (e.g., sodium alginate), propylene glycol alginate, dextran, dextrin, amylose, gelatin, collagen, pullulan, pectin, amylopectin, starch, amylopectin sodium semiglycolate, chitin, albumin, and natural polymers such as casein, polyglutamic acid, polyaspartic acid, methylcellulose, ethylcellulose, propylcellulose, ethylmethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose, carboxymethyl starch, alkali metal carboxymethylcellulose, alkali metal cellulose sulfate, cellulose graft polymers, and crosslinked gels. One or more polymers selected from the group consisting of semi-synthetic polymers such as cellulose acetate phthalate, starch-acrylic acid graft polymerization, phthalic anhydride-modified gelatin, and succinic acid-modified gelatin, polyvinyl alcohol, polyvinylpyrrolidone, polyvinyl methyl ether, carboxyvinyl polymers, vinylpyrrolidone-ethyl acrylate copolymer, vinylpyrrolidone-styrene copolymer, vinylpyrrolidone-vinyl acetate copolymer, vinyl acetate-(meth)acrylic acid copolymer, polyvinyl acetate-crotonic acid copolymer, N-vinylacetamide copolymers such as N-vinylacetamide-sodium acrylate copolymer, polyvinyl sulfonic acid, N-vinylacetamide crosslinked products, polyitaconic acid, polyhydroxyethyl acrylate, polyacrylamide, styrene-maleic anhydride copolymer, and acrylamide-acrylic acid copolymer can be used.

[0060] As the tackifier, for example, one or more selected from silicone rubber, polyisoprene rubber, styrene-block copolymer rubber, acrylic rubber, and natural rubber can be used.

[0061] Examples of oily raw materials include almond oil, olive oil, hardened oil, camellia oil, castor oil, Japan wax oil, coconut oil, beeswax, spermaceti, lanolin, carnauba wax, candelilla wax, liquid paraffin, petrolatum, microcrystalline wax, ceresin, squalene, lauric acid, myristic acid, palmitic acid, stearic acid, isostearic acid, oleic acid, lauryl alcohol, cetanol, stearyl alcohol, oleyl alcohol, octyldodecanol, cholesterol, hexyldecanol, hydroxypropyl methylcellulose ... One or more selected from white sterol, cetyl lactate, isopropyl myristate, hexyl laurate, myristyl myristate, isopropyl palmitate, octyldodecanol myristate, butyl stearate, cacao oil, Japan wax, jojoba oil, grapeseed oil, avocado oil, mink oil, egg yolk oil, ceresin wax, paraffin wax, behenic acid, isopropyl adipate, octyldodecyl myristate, octyldodecyl oleate, and cholesterol oleate can be used.

[0062] Examples of the liquid matrix include glycerin, polyhydric alcohols, ethanol, propanol, isopropanol, gelling agents, glycerin, methyl laurate, lauryl alcohol, glycerol monolaurate, oleic acid, oleyl alcohol, glycerol monooleate, glycerol dioleate, and glycerol trioleate, nicotinic acid, 2-pyrazinecarboxylic acid, sinapic acid (3,5-dimethoxy-4-hydroxycinnamic acid), 2,5-dihydroxybenzoic acid, 5-methoxysalicylic acid, α-cyano-4-hydroxycinnamic acid, 3-hydroxypiperidinol, 2-pyrazinecarboxylic acid ... One or more selected from choline acid, diaminonaphthalene, 2-(4-hydroxyphenylazo)benzoic acid, dithranol, succinic acid, 5-(trifluoromethyl)uracil, propylene glycol, dipropylene glycol, polypropylene glycol, glycerin, diglycerin, polyglycerin, ethylene glycol, diethylene glycol, polyethylene glycol, 1,3-butanediol, sorbitol, maltitol, erythritol, pentaerythritol, glucose, sucrose, maltose, xylose, and trehalose can be used.

[0063] Examples of fat-soluble substances include ascorbic acid isopalmitic acid, ascorbic acid-2-phosphate-6-palmitate, ascorbic acid-2-phosphate-6-isopalmitate, ascorbic acid tetrahexyldecanoic acid, ascorbic acid-6-palmitate, ascorbic acid-2,6-dipalmitate, ascorbic acid-6-stearate, retinol, retinoic acid, retinol palmitate, tocopheryl retinoate, retinoic acid palmitate, retinoic acid isopalmitate, retinoic acid stearate, retinol stearate, and astaxanthin. Ingredients: lutein, lycopene, beta-carotene, alpha-carotene, alpha-tocopherol, beta-tocopherol, gamma-tocopherol, dimethylglycine tocopherol, ubiquinone, coenzyme A, tocotrienol, mineral oil, liquid paraffin, squalane, isopropyl palmitate, isopropyl myristate, isooctyl myristate, isotridecyl myristate, octadecyl myristate, octyldodecyl myristate, isostearyl cholesteryl ester, 2-ethylhexanoic acid triglyceride, cetyl 2-ethylhexanoate, sunflower oil, olive oil Corn oil, jojoba oil, camellia oil, grapeseed oil, avocado oil, macadamia nut oil, almond oil, rice germ oil, clove oil, orange oil, spruce oil, pycnogenol, coenzyme A, iris extract oil, angelica extract oil, tsubaki extract oil, asparagus extract oil, avocado extract oil, amacha extract oil, almond extract oil, althea extract oil, arnica extract oil, aloe extract oil, apricot extract oil, apricot kernel extract oil, ginkgo extract oil, chinko extract oil, fennel extract oil, turmeric extract oil, oolong tea Extract oil, Uva-ursi extract oil, Star anise extract oil, Echinacea leaf extract oil, Enmeiso extract oil, Scutellaria root extract oil, Phellodendron bark extract oil, Coptis japonica extract oil, Barley extract oil, Panax ginseng extract oil, St. John's wort extract oil, Dead nettle extract oil, Ononis extract oil, Watercress extract oil, Orange extract oil, Dried seawater, Seaweed extract oil, Persimmon leaf extract oil, Kakyō extract oil, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk, Pueraria root extract oil, Chamomilla extract oil, Carrot extract oilArtemisia capillaris extract oil, oat extract oil, karkade extract oil, licorice extract oil, oil-soluble licorice extract oil, kiwi extract oil, bellflower extract oil, wood ear extract oil, cinchona extract oil, cucumber extract oil, paulownia leaf extract oil, guanosine, guava extract oil, kudzu extract oil, gardenia extract oil, kumazasa extract oil, sophora flavescens extract oil, walnut extract oil, chestnut extract oil, grapefruit extract oil, clematis extract oil, black rice extract oil, fat-soluble brown sugar extract, fat-soluble black vinegar extract, chlorella extract oil, Wa extract oil, gentian extract oil, geranium extract oil, black tea extract oil, yeast extract oil, magnolia bark extract oil, coffee extract oil, burdock extract oil, rice extract oil, fermented rice extract oil, fermented rice bran extract oil, rice germ oil, comfrey extract oil, collagen, bilberry extract oil, Chinese cabbage extract oil, Bupleurum extract oil, umbilical cord extract, saffron extract oil, salvia extract oil, soapwort extract oil, bamboo extract oil, hawthorn extract oil, sanshou extract oil, Japanese pepper extract oil, shiitake mushroom extract oil, geo Coriander extract oil, Lithospermum root extract oil, Perilla extract oil, Linden extract oil, Meadowsweet extract oil, Jatoba extract oil, Peony extract oil, Angelica root extract oil, Calamus root extract oil, Birch extract oil, White wood ear extract oil, Horsetail extract oil, Stevia extract oil, Stevia fermented product, Nishikawa willow extract oil, Ivy extract oil, Hawthorn extract oil, Elderberry extract oil, Yarrow extract oil, Peppermint extract oil, Sage extract oil, Mallow extract oil, Cnidium extract oil, Swertia japonica extract oil, Sophora japonica extract oil, Rhubarb extract oil, Soybean extract oil, Chinese laurel extract oil, Thyme extract oil, Dandelion extract oil, Lichen extract oil, Tea extract oil, Clove extract oil, Imperata corymb extract oil, Citrus tangerine extract oil, Tea tree oil, Sweet tea extract oil, Chili pepper extract oil, Angelica acutiloba extract oil, Calendula extract oil, Peach kernel extract oil, Spruce extract oil, Houttuynia cordata extract oil, Tomato extract oil, Natto extract oil, Carrot extract oil, Garlic extract oil, Wild rose extract oil, Hibiscus extract oil,Bakumondo oil extract, lotus oil extract, parsley oil extract, birch oil extract, honey, witch hazel oil extract, parietaria oil extract, sedge oil extract, bisabolol, cypress oil extract, bifidobacteria oil extract, loquat oil extract, coltsfoot oil extract, butterbur oil extract, poria extract, butcher's broom oil extract, grape oil extract, grape seed oil extract, propolis, loofah oil extract, safflower oil extract, peppermint oil extract, linden oil extract, peony oil extract, hop oil extract, squid extract, pine oil extract, horse chestnut oil extract, Asian skunk cabbage oil extract, soapberry oil extract, melissa oil extract, mozuku seaweed extract, peach oil extract, cornflower oil extract, eucalyptus oil extract, saxifrage oil extract, yuzu oil extract, lily oil extract, coix seed oil extract, yolk extract, One or more selected from among mokki extract oil, lavender extract oil, green tea extract oil, eggshell membrane extract oil, apple extract oil, rooibos tea extract oil, lychee extract oil, lettuce extract oil, lemon extract oil, forsythia extract oil, astragalus extract oil, rose extract oil, rosemary extract oil, Roman chamomile extract oil, royal jelly extract oil, burnet extract oil, dimethyl silicone oils such as octamethyltrisiloxane, decamethyltetrasiloxane, methylpolysiloxane, and highly polymerized methylpolysiloxane; cyclic silicone oils such as octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, methylcyclopolysiloxane, and methylpolycyclosiloxane; polyether-modified silicone oils; and methylphenyl silicone oils such as methylphenylpolysiloxane.

[0064] Examples of the polymeric carboxylate salt include acrylic resins such as polyacrylic acid, acrylic acid-acrylonitrile copolymer, potassium acrylate-acrylonitrile copolymer, vinyl acetate-acrylic acid ester copolymer, and acrylic acid-acrylic acid alkyl ester copolymer; styrene-acrylic resins such as styrene-acrylic acid copolymer, styrene-methacrylic acid copolymer, styrene-methacrylic acid-acrylic acid alkyl ester copolymer, styrene-α-methylstyrene-acrylic acid copolymer, and styrene-α-methylstyrene-acrylic acid-acrylic acid alkyl ester copolymer; styrene-maleic acid copolymer, styrene-maleic anhydride copolymer; vinyl acetate resins such as vinylnaphthalene-acrylic acid copolymer, vinyl acetate-ethylene copolymer, vinyl acetate-fatty acid vinylethylene copolymer, vinyl acetate-maleic acid ester copolymer, vinyl acetate-crotonic acid copolymer, and vinyl acetate-acrylic acid copolymer; and salts of any polyester or cellulose polymer.

[0065] Examples of the ultraviolet absorber include benzoic acid-based ultraviolet absorbers such as para-aminobenzoic acid, para-aminobenzoic acid monoglycerin ester, N,N-dipropoxypara-aminobenzoic acid ethyl ester, N,N-diethoxypara-aminobenzoic acid ethyl ester, N,N-dimethylpara-aminobenzoic acid ethyl ester, N,N-dimethylpara-aminobenzoic acid butyl ester, and N,N-dimethylpara-aminobenzoic acid ethyl ester; anthranilic acid-based ultraviolet absorbers such as homomenthyl-N-acetylanthranilate; salicylic acid-based ultraviolet absorbers such as salicylic acid and its sodium salt, amyl salicylate, menthyl salicylate, homomenthyl salicylate, octyl salicylate, phenyl salicylate, benzyl salicylate, and p-isopropanolphenyl salicylate; and octyl cinnamete. cinnamic acid-based ultraviolet absorbers such as ethyl-4-isopropyl cinnamate, methyl-2,5-diisopropyl cinnamate, ethyl-2,4-diisopropyl cinnamate, methyl-2,4-diisopropyl cinnamate, propyl-p-methoxycinnamate, isopropyl-p-methoxycinnamate, isoamyl-p-methoxycinnamate, 2-ethylhexyl-p-methoxycinnamate (octyl para-methoxycinnamate), 2-ethoxyethyl-p-methoxycinnamate (cinoxate), cyclohexyl-p-methoxycinnamate, ethyl-α-cyano-β-phenylcinnamate, 2-ethylhexyl-α-cyano-β-phenylcinnamate (octocurine), glyceryl mono-2-ethylhexanoyl-di-para-methoxycinnamate, ferulic acid and its derivatives;2,4-dihydroxybenzophenone, 2,2'-dihydroxy-4-methoxybenzophenone, 2,2'-dihydroxy-4,4'-dimethoxybenzophenone, 2,2',4,4'-tetrahydroxybenzophenone, 2-hydroxy-4- Benzophenone-based ultraviolet absorbers such as methoxybenzophenone (oxybenzone-3), 2-hydroxy-4-methoxy-4'-methylbenzophenone, 2-hydroxy-4-methoxybenzophenone-5-sulfonate, 4-phenylbenzophenone, 2-ethylhexyl-4'-phenyl-benzophenone-2-carboxylate, 2-hydroxy-4-n-octoxybenzophenone, and 4-hydroxy-3-carboxybenzophenone; 3-(4'-methylbenzylidene)-d,l-camphor, 3-benzylidene-d,l-camphor; 2-phenyl-5-methylbenzoxazole; 2,2'-hydroxy-5-methylphenylbenzotriazole; 2-(2'-hydroxy-5'-t-octylphenyl)benzotriazole; 2-(2'-hydroxy-5'-methylphenylbenzotriazole One or more compounds selected from the group consisting of dibenzalazine, dianisoylmethane, 5-(3,3-dimethyl-2-norbornylidene)-3-pentan-2-one, dibenzoylmethane derivatives such as 4-t-butylmethoxydibenzoylmethane, octyl triazone, urocanic acid derivatives such as urocanic acid and ethyl urocanate, hydantoin derivatives such as 2-(2'-hydroxy-5'-methylphenyl)benzotriazole, 1-(3,4-dimethoxyphenyl)-4,4-dimethyl-1,3-pentanedione, and 2-ethylhexyl dimethoxybenzylidene dioxoimidazolidinepropionate, phenylbenzimidazole sulfonic acid, terephthalylidene dicamphorsulfonic acid, drometrizole trisiloxane, methyl anthranilate, rutin and derivatives thereof, and oryzanol and derivatives thereof can be used.

[0066] Examples of whitening agents include hydroquinone glycosides such as arbutin and α-arbutin and their esters; ascorbic acid, ascorbic acid phosphate salts such as sodium ascorbic acid phosphate and magnesium ascorbic acid phosphate; ascorbic acid fatty acid esters such as ascorbic acid tetraisopalmitate; ascorbic acid alkyl ethers such as ascorbic acid ethyl ether; ascorbic acid glucosides and their fatty acid esters such as ascorbic acid-2-glucoside; ascorbic acid sulfate; tocopheryl acetate; Ascorbic acid derivatives such as lyl ascorbyl; kojic acid, ellagic acid, tranexamic acid and its derivatives, ferulic acid and its derivatives, placenta extract, glutathione, oryzanol, butylresorcinol, oil-soluble chamomilla extract, oil-soluble licorice extract, Nishikawa willow extract, saxifrage extract, glabridin, glabrene, liquiritin, isoliquiritin and licorice extracts containing these, placenta extract, carotenoids and animal and plant extracts containing these, neoagarobiose, agarose oligosaccharide, asparagus extract, Ibukitoranoi Extracts, pea extract, angelica tree extract, scutellaria root extract, ononis extract, seaweed extract, raspberry extract, lily extract, lily of the valley extract, kaempferia root extract, gokahi extract, vegetable oil containing linoleic acid, Chinese radish extract, hawthorn extract, sunflower extract, white lily extract, peony extract, sedge extract, mulberry extract, soybean extract, tea extract, angelica tree extract, molasses extract, white angelica tree extract, beech extract, grape seed extract, flordemanita extract, hop extract, squid extract, mocca extract, saxifrage extract, coix seed extract Extracts of monk fruit and monk fruit extract, asparagus, madder root, red grape, Mallotus japonicus, Akebia, hemp, morning glory, adzuki bean, Acacia, amacha, Gynostemma pentaphyllum, Japanese knotweed, fig, ginkgo, ylang-ylang, pitcher plant, plum, Uva-ursi, Satsuma mandarin, Eleuthero, Siberian laurel, Japanese sophora, pea, plantain, okra, Eulerian, Walnut, Ominaeshi, Dutch strawberry, persimmon, Japanese quince, cashew, valerian, trifoliate gourd, Chinese quince, guarana, platycodon, chrysanthemum, catalpa, dock, Gymnema sylvestre, agrimony, guava,Goji berry, kudzu, camphor tree, chestnut, cinnamon tree, bay laurel, cinnamon bark, strawberry, pepper, coffee, scrophulariaceae, colombo, camellia, Japanese pepper, saffron, cherry blossom, pomegranate, sanzu kon, sanpenzu, ash, calamus, watermelon, stevia, plum, ivy, pear, yarrow, juniper, horseradish, Japanese parsley, water dropwort, senega, senna, rhubarb, bitter orange, tamarind, elm, dandelion, chicory, clove, siberian laurel, Chinese laurel, evening jasmine, centella, dayflower, vine, Japanese walnut, wax gourd, eucommia, taro, shepherd's purse, summer tangerine, nandina, bitter orange, yarrow, pineapple One or more plant extracts selected from the group consisting of: Puru, hibiscus, papaya, basil, lotus, naked barley, Belamcanda chinensis, peanut, Japanese knotweed, water chestnut, pistachio, hiba, matsutake mushroom, angelica tree, loquat, coltsfoot, balsam, Fujibakama, blueberry, Saghurt, ground cherry, magnolia, Japanese quince, Chinese quince, ephedra, mango, Ganoderma lucidum, Bupleurum falcatum, Lythrum salicaria, mitsuba, mimosa, melilot, melon, magnolia, Momordica grosvenorii, mulukhiyah, bean sprout, Yakuchi, yakumozu, knapweed, palm, palm tree, mistletoe, willow polygonum, pokeweed, Japanese laurel, mugwort, rye, orchid, longan, apple, lychee, and forsythia can be used.

[0067] Examples of vitamins and derivatives thereof include vitamin A such as retinol, retinol acetate, and retinol palmitate; vitamin B such as thiamine hydrochloride, thiamine sulfate, riboflavin, riboflavin acetate, riboflavin butyrate, pyridoxine hydrochloride, pyridoxine dioctanoate, pyridoxine dipalmitate, flavin adenine dinucleotide, cyanocobalamin, folic acids, nicotinic acids such as nicotinamide and benzyl nicotinate, and cholines; vitamin C such as ascorbic acid and its sodium salts; vitamin D; vitamin E such as α-, β-, γ-, and δ-tocopherol; other vitamins such as pantothenic acid and biotin; ascorbic acid phosphate sodium salt and ascorbic acid phosphate ester One or more compounds selected from ascorbic acid phosphate salts such as ascorbic acid phosphate magnesium salt, ascorbic acid fatty acid esters such as ascorbic acid tetraisopalmitate, ascorbyl stearate, ascorbyl palmitate, and ascorbyl dipalmitate, ascorbic acid alkyl ethers such as ascorbic acid ethyl ether, ascorbic acid glucoside and its fatty acid esters such as ascorbic acid-2-glucoside, ascorbic acid derivatives such as tocopheryl ascorbyl phosphate; vitamin derivatives such as tocopherol nicotinate, tocopherol acetate, tocopherol linoleate, tocopherol ferulate, and tocopherol phosphate, and tocotrienols can be used.

[0068] Examples of anti-inflammatory agents, anti-inflammatory agents, hair growth agents, blood circulation promoters, stimulants, hormones, anti-wrinkle agents, anti-aging agents, firming agents, cooling agents, warming agents, wound healing promoters, irritation relievers, analgesics, and cell activators include glycyrrhizinic acid and its derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, guaiazulene, allantoin, indomethacin, zinc oxide, hydrocortisone acetate, prednisone, diphedramine hydrochloride, and chlorpheniramine maleate; plant extracts such as peach leaf extract and mugwort leaf extract; Swertia japonica extract, capsicum tincture, and ginger tincture , ginger extract, cantharides tincture and other plant extracts and tinctures; capsaicin, nonylic acid valenylamide, zingerone, ichthammol, tannic acid, borneol, cyclandelate, cinnarizine, tolazoline, acetylcholine, verapamil, cepharanthine, γ-oryzanol, cepharanthine, vitamin E and derivatives such as tocopherol nicotinate and tocopherol acetate, γ-oryzanol, nicotinic acid and derivatives such as nicotinamide, nicotinic acid benzyl ester, inositol hexanicotinate, nicotine alcohol, allantoin , Photosensitizer 301, Photosensitizer 401, Capronium chloride, Pentadecanoic acid monoglyceride, Flavanonol derivatives, Stigmasterol or Stigmastanol and its glycosides, Minoxidil; Estradiol, Estrone, Ethinylestradiol, Cortisone, Hydrocortisone, Prednisone; Retinols, Retinoic acids, Tocopheryl retinoate; Lactic acid, Glycolic acid, Gluconic acid, Fruit acid, Salicylic acid and its glycosides, esters, etc., Hydroxycapric acid, Long-chain α-hydroxy fatty acids, Long-chain α-hydroxy fatty acid co α- or β-hydroxy acids such as esteril and their derivatives; γ-aminobutyric acid, γ-amino-β-hydroxybutyric acid; carnitine; creatine; ceramides, sphingosines; caffeine, xanthine, etc. and their derivatives; antioxidants / active oxygen scavengers such as coenzyme Q10, carotene, lycopene, astaxanthin, etc.; catechins; flavones such as quercetin; isoflavones; gallic acid and ester sugar derivatives; polyphenols such as tannin, sesamin, protoanthocyanidin, chlorogenic acid, apple polyphenol, etc.; rutin and glycoside derivatives, etc.One or more substances selected from the group consisting of hesperidin and derivatives thereof such as glycosides; lignan glycosides; licorice extract-related substances such as glabridin, glabrene, liquiritin, and isoliquiritin; lactoferrin; shogaol, gingerol; fragrance substances and derivatives thereof such as menthol, camphor, and cedrol; capsaicin, vanillin, and derivatives thereof; insect repellents such as diethyltoluamide; and complexes of physiologically active substances and cyclodextrins can be used.

[0069] Examples of plant, animal, and microbial extracts include iris extract, angelica extract, douglas fir extract, asparagus extract, avocado extract, hydrangea extract, almond extract, althaea extract, arnica extract, aloe extract, apricot extract, apricot kernel extract, ginkgo extract, chinko extract, fennel extract, turmeric extract, oolong tea extract, uva-ursi extract, angelica tree extract, echinacea leaf extract, emmeiso extract, scutellaria root extract, phellodendron bark extract, coptis japonica extract, barley extract, ginseng extract, and St. John's wort extract , Lamium extract, Ononis extract, Watercress extract, Orange extract, Dried seawater, Seaweed extract, Oyster leaf extract, Kakyoku extract, Hydrolyzed elastin, Hydrolyzed wheat powder, Hydrolyzed silk, Pueraria root extract, Chamomilla extract, Oil-soluble Chamomilla extract, Carrot extract, Artemisia capillaris extract, Oat extract, Karkade extract, Licorice extract, Oil-soluble Licorice extract, Kiwi extract, Angelica root extract, Wood ear extract, Cinchona extract, Cucumber extract, Paulownia leaf extract, Guanosine, Guava extract, Sophora root extract, Gardenia extract, Ku Sasa extract, Sophora flavescens extract, Walnut extract, Chestnut extract, Grapefruit extract, Clematis extract, Black rice extract, Brown sugar extract, Black vinegar, Chlorella extract, Mulberry extract, Gentian extract, Geranium extract, Black tea extract, Yeast extract, Magnolia bark extract, Coffee extract, Burdock extract, Rice extract, Fermented rice extract, Fermented rice bran extract, Rice germ oil, Comfrey extract, Collagen, Cowberry extract, Chinese radish extract, Bupleurum extract, Umbilical cord extract, Saffron extract, Salvia extract, Soapwort extract, Bamboo shoot extract, Hawthorn extract , Sandalwood extract, Zanthoxylum pepper extract, Shiitake mushroom extract, Rehmannia root extract, Lithospermum root extract, Perilla extract, Tilia extract, Meadowsweet extract, Jatoba extract, Peony extract, Angelica root extract, Calamus root extract, Birch extract, White wood ear extract, Horsetail extract, Stevia extract, Stevia fermented product, Nishikawa willow extract, Ivy extract, Hawthorn extract, Elderberry extract, Yarrow extract, Peppermint extract, Sage extract, Mallow extract, Cnidium extract, Swertia japonica extract, Sophora japonica extract,Rhubarb extract, soybean extract, ginseng extract, thyme extract, dandelion extract, lichen extract, tea extract, clove extract, Imperata cylindrica extract, tangerine extract, tea tree oil, sweet tea extract, chili pepper extract, angelica extract, calendula extract, peach kernel extract, spruce extract, houttuynia cordata extract, tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, burdock extract, lotus extract, parsley extract, birch extract, honey, witch hazel extract, parietaria extract, jasmine extract, bisabolol, cypress extract, bifidobacteria extract, loquat extract, coltsfoot extract, butterbur extract, poria coccinellifera extract, butcher's broom extract, grape extract, bud One or more selected from the group consisting of cork seed extract, propolis, loofah extract, safflower extract, peppermint extract, linden extract, peony extract, hop extract, squid extract, pine extract, horse chestnut extract, skunk cabbage extract, soapberry extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, coix seed extract, mugwort extract, lavender extract, green tea extract, eggshell membrane extract, apple extract, rooibos tea extract, lychee extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract, rosemary extract, Roman chamomile extract, royal jelly extract, and burnet extract can be used.

[0070] Examples of the antipruritic agent, exfoliant / dissolver, antiperspirant, freshener, enzyme, and nucleic acid that can be used include one or more selected from diphenhydramine hydrochloride, chlorpheniramine maleate, camphor, and substance P inhibitors; salicylic acid, sulfur, resorcinol, selenium sulfide, and pyridoxine; aluminum chlorohydrate, aluminum chloride, zinc oxide, and zinc paraphenolsulfonate; menthol and methyl salicylate; citric acid, tartaric acid, lactic acid, aluminum potassium sulfate, and tannic acid; superoxide dismutase, catalase, lysozyme chloride, lipase, papain, pancreatin, and protease; ribonucleic acid and salts thereof, deoxyribonucleic acid and salts thereof, and adenosine triphosphate disodium.

[0071] As the astringent, for example, one or more selected from citric acid, tartaric acid, lactic acid, aluminum chloride, aluminum sulfate, aluminum allantoin chlorohydroxyaluminum, aluminum allantoin dihydroxyaluminum, aluminum phenolsulfonate, zinc paraphenolsulfonate, zinc sulfate, and aluminum chlorohydroxide can be used.

[0072] Examples of fragrances include plant-based fragrances such as mustard oil, orange oil, pepper oil, jasmine oil, cedar oil, calamus oil, terpine oil, orange blossom oil, rose oil, eucalyptus oil, lime oil, lemon oil, Japanese peppermint oil, and rosemary oil; animal-based fragrances such as musk, leopard print, silkworm cocoon, and agave; hydrocarbon-based fragrances such as bromostyrol, pinene, and limonene; alcohol-based fragrances such as benzyl alcohol and 1-menthol; ester-based fragrances such as ethyl acetate and methyl salicylate; aldehyde-based fragrances such as benzaldehyde and salicylic aldehyde; ketone-based fragrances such as camphor, muscone, musk ketone, and 1-menthone; ether-based fragrances such as safrole; phenol-based fragrances such as thymol; lactone-based fragrances; acid-based fragrances such as phenylacetic acid; and nitrogen compound-based fragrances such as indole.Acetyl cedrene, amyl cinnamaldehyde, allyl amyl glycolate, β-ionone, ISOE Super, isobutylquinoline, iris oil, iron, ylang-ylang oil, undecanal, undecenal, γ-undecalactone, estragole, oakmoss, opoponax resinoid, eugenol, aurantiol, galacsolid, carvacrol, L-carvone, canon, carrot seed oil, clove oil, methyl cinnamate, geraniol, geranyl nitrile, isobornyl acetate, geranyl acetate, dimethicone acetate Benzyl carbinyl, styrallyl acetate, cedryl acetate, terpinel acetate, p-t-butylcyclohexyl acetate, vetiveryl acetate, benzyl acetate, linalyl acetate, isopentyl salicylate, benzyl salicylate, sandalwood oil, santalol, cyclamen aldehyde, cyclopentadecanolide, methyl dihydrojasmonate, dihydromyrcenol, jasmine absolute, jasmine lactone, cis-jasmone, citral, citronenol, citronellal, cinnamon bark oil, 1,8-cineole, cinnamamia Aldehyde, styrax resinoid, cedarwood oil, cedrene, cedrol, celery seed oil, thyme oil, damascone, damascenone, tuberose absolute, decanal, decalactone, terpineol, gamma-terpinene, triplal, nerol, nonanal, 2,6-nonadienol, nonalactone, patchouli alcohol, vanilla absolute, vanillin, basil oil, patchouli oil, hydroxycitronellal, alpha-pinene, piperitone, phenethyl alcohol, phenylacetaldehyde, petitgrain oil, hexyl One or more selected from synthetic fragrances and natural fragrances, such as lucinnamaldehyde, cis-3-hexenol, balsam of Peru, vetiver oil, vetiverol, peppermint oil, pepper oil, heliotropin, bergamot oil, benzyl benzoate, borneol, myrresinoid, methylnonylacetaldehyde, γ-methylionone, menthol, β-ionone, lavender oil, D-limonene, linalool, lyral, lilial, rose absolute, rose oxide, rose oil, and various essential oils, as well as various blended fragrances, can be used.

[0073] Examples of dyes, colorants, dyes, and pigments include Brown No. 201, Black No. 401, Purple No. 201, Purple No. 401, Blue No. 1, Blue No. 2, Blue No. 201, Blue No. 202, Blue No. 203, Blue No. 204, Blue No. 205, Blue No. 403, Blue No. 404, Green No. 201, Green No. 202, Green No. 204, Green No. 205, Green No. 3, Green No. 401, and Green No. 402. No., Red No. 102, Red No. 104-1, Red No. 105-1, Red No. 106, Red No. 2, Red No. 201, Red No. 202, Red No. 203, Red No. 204, Red No. 205, Red No. 206, Red No. 207, Red No. 208, Red No. 213, Red No. 214, Red No. 215, Red No. 218, Red No. 219, Red No. 220, Red No. 221, Red No. 223, Red No. 225, Red No. 226, Red No. 227, Red No. 228, Red No. 230-1, Red No. 230-2, Red No. 231, Red No. 232, Red No. 3, Red No. 401, Red No. 404 , Red No. 405, Red No. 501, Red No. 502, Red No. 503, Red No. 504, Red No. 505, Red No. 506, Orange No. 201, Orange No. 203, Orange No. 204, Orange No. 205 , Orange No. 206, Orange No. 207, Orange No. 401, Orange No. 402, Orange No. 403, Yellow No. 201, Yellow No. 202-1, Yellow No. 202-2, Yellow No. 203, Yellow No. 204, Yellow No. 205, Yellow No. 4, Yellow No. 401, Yellow 402, Yellow No. 403-1, Yellow 404, Yellow 405, Yellow 406, Yellow 407, Yellow No. 5 and other legal dyes; Acid Other acid dyes such as Arianor Red 14; basic dyes such as Arianor Sienna Brown, Arianor Madder Red, Arianor Steel Blue, and Arianor Straw Yellow; HC Yellow 2, HC Yellow 5, HC Red 3, 4-hydroxypropylamino-3-nitrophenol, N,N'-bis(2-hydroxyethyl)-2-nitro-p-phenylenediamine, HC Blue 2, and Basic Blue 26 and other nitro dyes; disperse dyes; inorganic white pigments such as titanium dioxide and zinc oxide; inorganic red pigments such as iron oxide (red iron oxide) and iron titanate; inorganic brown pigments such as γ-iron oxide; inorganic yellow pigments such as yellow iron oxide and ochre; inorganic black pigments such as black iron oxide and low-order titanium oxide; inorganic purple pigments such as mango violet and cobalt violet;Inorganic green pigments such as chromium oxide, chromium hydroxide, and cobalt titanate; inorganic blue pigments such as ultramarine and Prussian blue; pearl pigments such as titanium dioxide-coated mica, titanium dioxide-coated bismuth oxychloride, titanium dioxide-coated talc, colored titanium dioxide-coated mica, bismuth oxychloride, and fish scale foil; metal powder pigments such as aluminum powder, copper powder, and gold; surface-treated inorganic and metal powder pigments; Red No. 201 Zirconium, such as Red 202, Red 204, Red 205, Red 220, Red 226, Red 228, Red 405, Orange 203, Orange 204, Yellow 205, Yellow 401, Blue 404, Red 3, Red 104, Red 106, Red 227, Red 230, Red 401, Red 505, Orange 205, Yellow 4, Yellow 5, Yellow 202, Yellow 203, Green 3, Blue 1, etc. One or more types selected from the group consisting of organic pigments such as aluminum or aluminum lake; surface-treated organic pigments; natural pigments and dyes such as anthraquinones such as astaxanthin and alizarin, anthocyanidin, β-carotene, catenal, capsanthin, chalcone, carthamine, quercetin, crocin, chlorophyll, curcumin, naphthoquinones such as cochineal and shikonin, bixin, flavones, betacyanidin, henna, hemoglobin, lycopene, riboflavin, and rutin; oxidation dye intermediates and couplers such as p-phenylenediamine, toluene-2,5-diamine, o-, m-, or p-aminophenol, m-phenylenediamine, 5-amino-2-methylphenol, resorcinol, 1-naphthol, 2,6-diaminopyridine, and salts thereof; autoxidation dyes such as indoline; and dihydroxyacetone can be used.

[0074] Examples of anti-inflammatory analgesics include salicylic acid, glycol salicylate, methyl salicylate, 1-menthol, camphor, sulindac, trimethine sodium, naproxen, fenbufen, piroxicam, triamcinolone, hydrocortisone acetate, indomethacin, ketoprofen, acetaminophen, mefenamic acid, flufenamic acid, ibufenac, loxoprofen, tiaprofen, pranoprofen, fenbufen, diclofenac, and diclofenac. One or more compounds selected from the group consisting of phenac sodium, alclofenac, lornoxicam, pranoprofen, oxyphenbutazone, ibuprofen, felbinac, ketorolac, bermoprofen, nabumetone, naproxen, flurbiprofen, fluocinonide, clobetasol propionate, and COX-2 inhibitors (celecoxib, rofecoxib, valecoxib, parecoxib, valedecoxib, etodrug, nimesulide, and meloxicam) can be used.

[0075] Examples of antifungal agents that can be used include one or more selected from clotrimazole, econazole nitrate, omoconazole nitrate, tioconazole nitrate, ketoconazole nitrate, miconazole nitrate, isoconazole nitrate, tolnaftate, sulconazole nitrate, pyrrolnitrin, pimafucin, undecylenic acid, salicylic acid, siccanin, nystatin, nornaftate, exalamide, phenyliodoundecinoate, thianthol, ciclopirox olamine, haloprogin, trichomycin, variotin, pentamycin, and amphotericin B.

[0076] As the antihistamine, for example, one or more selected from antibiotics such as tetracycline hydrochloride, diphenhydramine hydrochloride, chlorpheniramine, diphenylimidazole, and chloramphenicol, diphenhydramine, chlorpheniramine maleate, diphenhydramine hydrochloride, chlorpheniramine, and diphenylimidazole can be used.

[0077] As the hypnotic sedative, for example, one or more selected from phenobarbital, amobarbital, cyclobarbital, lorazepam, and haloperidol can be used.

[0078] As the tranquilizer, for example, one or more selected from fluphenazine, thioridazine, diazepam, flunitrazepam, and chlorpromazine can be used.

[0079] As the antihypertensive agent, for example, one or more selected from clonidine, clinidine hydrochloride, pindolol, propranolol, propranolol hydrochloride, bufuranol, indenolol, bucumolol, and nifedipine can be used.

[0080] As the hypotensive diuretic, for example, one or more selected from hydrothiazide and cyclopenthiazide can be used.

[0081] As the antibiotic, for example, one or more selected from penicillin, tetracycline, oxytetracycline, fradiomycin sulfate, erythromycin, and chloramphenicol can be used.

[0082] As the anesthetic, for example, one or more selected from lidocaine, benzocaine, ethyl aminobenzoate, and dibucaine can be used.

[0083] As the antibacterial substance, for example, one or more selected from benzalkonium chloride, nitrofurazone, nystatin, acetosulfamine, and clotrimazole can be used.

[0084] As the antiepileptic drug, for example, one or more selected from nitrazepam, meprobamate, and clonazepam can be used.

[0085] As the coronary vasodilator, for example, one or more selected from nitroglycerin, nitroglycerin, isosorbidin nitrate, erythritol tetranitrate, pentaerythritol tetranitrate, and propatyl nitrate can be used.

[0086] As the herbal medicine, for example, one or more selected from Phellodendron bark, Phellodendron hibachi, Onji, Zedoary, Chamomile, Calonin, Licorice, Platycodon grandiflorum, Apricot kernel, Bezoar, Gomoku, Sakka, Bupleurum chinense, Saishin, Shazenshi, Cimicifuga, Senega, Atractylodes rhizome, Sophora rhizome, Clove, Tangerine peel, Ipecac, Nandina fruit, Fritillaria rosa, Bakumondo, Pinellia japonica, Atractylodes rhizome, Henneyus, Saghurt, and Ephedra can be used.

[0087] As the antipruritic agent, for example, one or more selected from camphor, thymol, menthol, polyoxyethylene lauryl ether, antihistamines, and ethyl aminobenzoate can be used.

[0088] As the keratin softening and exfoliating agent, for example, one or more selected from sulfur, thioxolone, selenium sulfide, salicylic acid, and resorcinol can be used.

[0089] Examples of the ultraviolet blocking agent that can be used include benzophenone-based agents such as ASL-24, Cyasorb UV-9, and Uvinul M-40; benzoic acid-based agents such as Salol; azole-based agents such as Tinuvin P; nitrile-based agents such as Uvinul N-35; urea-based agents such as Ancour UA; para-amino acid-based agents such as Neo Heliopan Give tan F, 2-hydroxy-4-methoxybenzophenone, octyl dimethyl para-aminobenzoate, and ethylhexyl para-methoxycyanamate; salicylic acid-based agents; benzofuran-based agents; coumarin-based agents; and azole-based agents.

[0090] Examples of antiseptic disinfectants include acids and salts thereof such as benzoic acid, salicylic acid, dehydroacetic acid, sorbic acid, and boric acid; phenols such as phenol, chlorocresol, chloroxylenol, isopropylmethylphenol, resorcinol, orthophenylphenol, parahydroxybenzoic acid esters, phenoxyethanol, thymol, hinokitiol, and thioxolone; halogenated bisphenols such as hexachlorophene and 2,4,4'-trichloro-2'-hydroxydiphenyl ether; and trichlorocarbanilides. and the like; amide compounds such as amide, halocarban, and udecylenic acid monoethanolamide; quaternary ammonium compounds such as benzalkonium chloride, alkylisoquinolinium bromide, benzethonium chloride, and cetylpyridinium chloride; amphoteric surfactants such as lauryldi(aminoethyl)glycine; 2-pyridinethiol-1-oxide zinc salt, gluconic acid, chlorhexidine, thiram, N-trichloromethylthio-4-cyclohexene-1,2-dicarboximide; and chlorobutanol.

[0091] Examples of antioxidants include methyl L-ascorbate, ethyl L-ascorbate, propyl L-ascorbate, butyl L-ascorbate, pentyl L-ascorbate, L-ascorbic acid-2-palmitate, 2-isopalmitate L-ascorbic acid-2-stearate, 2-isostearate L-ascorbic acid-6-palmitate, 6-isopalmitate L-ascorbic acid-6-stearate, 6-isostearate L-ascorbic acid-2,6-dipalmitate, 2,6-diisopalmitate L-ascorbic acid, 2,6-distearate L-ascorbic acid,6-diisostearate, L-ascorbic acid 2-glucoside 6-palmitate, L-ascorbic acid 2-glucoside 6-isopalmitate, L-ascorbic acid 2-glucoside 6-stearate, L-ascorbic acid 2-glucoside 6-isostearate, L-ascorbic acid 2-glucoside 6-tocopheryl, L-ascorbic acid 2-sulfate 6-palmitate, L-ascorbic acid 2-sulfate 6-isopalmitate , L-ascorbic acid 2-sulfate-6-stearate, L-ascorbic acid 2-sulfate-6-isostearate, L-ascorbic acid 2-sulfate-6-tocopheryl, L-ascorbic acid 2-maleic acid-6-palmitate, L-ascorbic acid 2-maleic acid-6-isopalmitate, L-ascorbic acid 2-maleic acid-6-stearate, L-ascorbic acid 2-maleic acid-6-isostearate, L-ascorbic acid 2-maleic acid-6-isostearate Leic acid-6-tocopheryl, L-ascorbic acid-2-phosphate-6-palmitate, L-ascorbic acid-2-phosphate-6-isopalmitate, L-ascorbic acid-2-phosphate-6-stearate, L-ascorbic acid-2-phosphate-6-isostearate, L-ascorbic acid-2-phosphate-6-tocopheryl, palmitoyl 2-0-L-ascorbic acid, isopalmitoyl 2-0-L-ascorbic acid phosphate, stearyl 2-0-L-ascorbic acid One or more compounds selected from the group consisting of scorbic acid phosphate, isostearyl 2-0-L-ascorbic acid phosphate, tocopheryl 2-0-L-ascorbic acid phosphate, retinoyl 2-0-L-ascorbic acid phosphate, tocopheryl phosphate, tocotrienol phosphate, tocopheryl glucoside, tocopheryl sulfate, tocopheryl dimethylglycine, retinoyl phosphate, retinoyl glucoside, retinoyl sulfate, and retinoyl dimethylglycine can be used.

[0092] Examples of additives include hydrocarbons such as hydrocarbons, waxes, fatty acids, higher alcohols, ester oils, silicone oils, fluorine-based oils, ozokerite, squalane, squalene, ceresin, paraffin, paraffin wax, liquid paraffin, pristane, polyisobutylene, microcrystalline wax, and petrolatum; waxes such as beeswax, carnauba wax, candelilla wax, and whale wax; animal oils such as beef tallow, beef leg fat, beef bone fat, hardened beef tallow, hardened oil, turtle oil, lard, horse fat, mink oil, liver oil, and egg yolk oil; lanolin, liquid lanolin, and reduced lanolin; Lanolin derivatives such as lanolin alcohol, hard lanolin, lanolin acetate, lanolin fatty acid isopropyl, phospholipids, phosphatidylcholine, POE lanolin alcohol ether, POE lanolin alcohol acetate, lanolin fatty acid polyethylene glycol, and POE hydrogenated lanolin alcohol ether, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid, oleic acid, linoleic acid, arachidonic acid, eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), isostearic acid, 12-hydroxystearyl alcohol, hydroxypropyl methylcellulose ... fatty acids such as carboxylic acid, lauryl alcohol, myristyl alcohol, palmityl alcohol, stearyl alcohol, behenyl alcohol, hexadecyl alcohol, oleyl alcohol, isostearyl alcohol, hexyldodecanol, octyldodecanol, cetostearyl alcohol-2-decyltetradecynol, cholesterol, phytosterol, sitosterol, lanosterol, POE cholesterol ether, monostearyl glycerin ether (batyl alcohol), and other higher alcohols, diisobutyl adipate, adipic acid 2-hexyldecyl, di-2-heptylundecyl adipate, N-alkyl glycol monoisostearate, isocetyl isostearate, trimethylolpropane triisostearate, ethylene glycol di-2-ethylhexanoate, cetyl 2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, pentaerythritol tetra-2-ethylhexanoate, cetyl octanoate, octyldodecyl gum ester, oleyl oleate, octyldodecyl oleate, decyl oleate, neopentyl glycol dicaprate,Ester oils such as triethyl citrate, 2-ethylhexyl succinate, amyl acetate, ethyl acetate, butyl acetate, isocetyl stearate, butyl stearate, diisopropyl sebacate, di-2-ethylhexyl sebacate, cetyl lactate, myristyl lactate, isopropyl palmitate, 2-ethylhexyl palmitate, 2-hexyldecyl palmitate, 2-heptylundecyl palmitate, cholesteryl 12-hydroxystearate, dipentaerythritol fatty acid esters, isopropyl myristate, octyldodecyl myristate, 2-hexyldecyl myristate, myristyl myristate, hexyldecyl dimethyloctanoate, ethyl laurate, hexyl laurate, 2-octyldodecyl N-lauroyl-L-glutamate, and diisostearyl malate, acetoglyceride, and triisooctanoic acid glyceride One or more selected from the group consisting of glyceride oils such as triisostearate glyceride, triisopalmitate glyceride, tri-2-ethylhexanoate glyceride, monostearate glyceride, di-2-heptylundecanoate glyceride, and trimyristate glyceride, higher alkoxy-modified silicones such as dimethylpolysiloxane, methylphenylpolysiloxane, methylhydrogenpolysiloxane, octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethylcyclohexasiloxane, tetramethyltetrahydrogencyclotetrasiloxane, and stearoxysilicone, higher fatty acid-modified silicones, silicone resins, silicone rubbers, and silicone resins, and fluorine-based oils such as perfluoropolyether, perfluorodecalin, and perfluorooctane can be used.

[0093] As the metal soap, for example, one or more selected from 12-hydroxyaluminum stearate, zinc stearate, aluminum stearate, calcium stearate, magnesium stearate, zinc myristate, magnesium myristate, zinc cetyl phosphate, calcium cetyl phosphate, sodium zinc cetyl phosphate, zinc laurate, and zinc undecylenate can be used.

[0094] Next, the present disclosure will be described more specifically with reference to examples and comparative examples.

[0095] (Production of Bayberry Extract (Bayberry Leaf Extract)) 10 kg of a 30% w / w 1,3-butylene glycol solution prepared from 7 kg of distilled water and 3 kg of 1,3-butylene glycol was heated to 70-80°C, and 100 g of crushed dried Bayberry leaves was added to this solution, followed by stirring for 2 hours while maintaining the heated state at 70-80°C, to obtain an extract. The extract was filtered through 5B filter paper (manufactured by ADVANTEC), and distilled water was added to the filtrate to readjust the volume to 10 kg, to obtain a Bayberry extract (Bayberry Leaf Extract).

[0096] (Evaluation of Gene Expression) NHEK cells (normal human epidermal keratinocytes) were seeded in a 96-well plate, and treatment with bayberry extract (bayberry leaf extract treatment) began the day after seeding. KG2 (Kurabo Industries, Ltd.) medium was used for seeding, and KB2 (Kurabo Industries, Ltd.) was used as the test medium for dissolving the test substance. Filter-sterilized bayberry extract (bayberry leaf extract) prepared as described above was mixed with the medium at 1%, and test media with different concentrations were prepared in a 3-fold dilution series. 30% 1,3-butylene glycol was added to the control and diluted concentration treatment groups to a final concentration of 1%. qPCR was performed to examine gene changes 24 hours after the addition of the test medium.

[0097] To prepare the reverse transcription product for qPCR, a SuperPrep® II Cell Lysis & RT Kit for qPCR (Toyobo Co., Ltd.) was used, and reverse transcription reaction was performed according to the protocol provided by the manufacturer. Using the resulting reverse transcription product as a template and THUNDERBIRD® SYBR qPCR Mix (Toyobo Co., Ltd.) as a qPCR reagent, gene expression analysis of each gene (aquaporin 3, filaggrin, and claudin 1 genes) was performed. The results of the gene expression analysis are shown in Figure 1. Figure 1(A) shows the results of expression analysis of the aquaporin 3 gene, Figure 1(B) shows the results of expression analysis of the filaggrin gene, and Figure 1(C) shows the results of expression analysis of the claudin 1 gene.

[0098] The following primer set was used to amplify the target gene. Hereinafter, Forward Primer is abbreviated as "FP" and Reverse Primer is abbreviated as "RP."・Aquaporin 3 (AQP3) Primer Set "FP" 5'-GCCTTTGGCTTTGCTGTCACTC-3' "RP" 5'-AGCTGGTTGTCGGCGAAGTG-3' ・Filaggrin (FLG) Primer Set "FP" 5'-TCGGCAATCCTGAAGAATCC-3' "RP" 5'-CTGTGCTTTCTGTGCTTGTGTC-3' ・Claudin 1 (CLDN1) Primer Set "FP" 5'-GACGATGAGGTGCAGAAGATGAG-3' "RP" 5'-AGCCAGTGAAGAGAGCCTGAC-3' ・PPIA Primer Set "FP" 5'-TCATCTGCACTGCCAAGACTG-3' "RP" 5'-TGGTGATCTTCTTGCTGGTCTTG-3' The PPIA gene was used as a housekeeping gene for correcting gene expression.

[0099] As shown in Figure 1, it was confirmed that the Bayberry extract increased the expression of the aquaporin 3 gene, filaggrin gene, and claudin 1 gene, which contribute to improving skin function. This demonstrated that the Bayberry extract has the function of improving skin function.

[0100] (Evaluation of Promotion of Tight Junction Formation) Normal human epidermal keratinocytes were seeded onto Lab-Tek II chamber slides (Nunc) using KG2 medium (Kurabo Industries, Ltd.). The following day, the test medium was replaced with KB2 medium (Kurabo Industries, Ltd.) supplemented with the test substance at the designated concentration, and the evaluation was initiated. 24 hours after the test medium was replaced, the cells were fixed using PBS(-) containing 4% formalin and permeabilized with PBS(-) containing 0.1% Triton X-100. Subsequently, the cells were blocked with PBS(-) containing 1% BSA, followed by fluorescent immunostaining. Figure 2 shows fluorescent immunostaining images of claudin-1 and ZO-1.

[0101] For fluorescent immunostaining, mouse anti-CLDN1 (A-9, Santa Cruz) and rabbit anti-ZO-1 (Proteintech) were used as primary antibodies, and Alexa Fluor 488-AffiniPure Goat Anti-Mouse IgG (H + L) and Rhodamine Red-x-AffiniPure Donkey Anti-Rabbit IgG (H + L) (both Jackson ImmunoResearch Laboratories) were used as secondary antibodies. After antibody staining, nuclear staining was performed using VECTASHIELD PLUS Antifade Mounting Medium with DAPI (Vector Laboratories) as a mounting medium. Image data were acquired using a ZOE Fluorescent Cell Imager (Bio-Rad). To eliminate bias, random multiple fields of view were photographed under the same conditions with a fixed exposure time to obtain data suitable for quantitative analysis. Image analysis was performed using ImageJ, an open-source, public-domain image processing software.

[0102] (Evaluation of Claudin 1 Expression Levels) Quantitative comparison was performed using a value obtained by dividing the sum of signal intensities derived from claudin 1 (CLDN1) in the image data representatively shown in Figure 2 by the cell number count using DAPI. Figure 3 shows the fluorescence intensity derived from claudin 1. The fluorescence intensity signal is related to the expression level of the claudin 1 gene, and as shown in Figure 3, it was revealed that the extract of Bayberry can increase the expression of the claudin 1 gene, which contributes to the improvement of skin function. These results also clearly show that the extract of Bayberry has the function of improving skin function.

[0103] (Fluorescence Intensity Values ​​of ZO-1-Derived Signals) The distribution of ZO-1-derived signals on a histogram of the representative image data shown in Figure 2 was divided and quantified by pixel fluorescence intensity. For arbitrary divisions, the histogram values ​​of the control ZO-1 image were used, and the fluorescence intensity values ​​including the bottom 50% and bottom 75% of pixels were used as delimiters. The number of pixels in the low (Low: ∼50%), medium (Mid: 50-75%), and high (High: 75% and above) ranges were divided by the total number of pixels, and the percentage of pixels in each range was quantified. Figure 4 shows the histogram of ZO-1-derived fluorescent signals, and Figure 5 shows the distribution of pixel fluorescence intensity values. Figure 4 confirms that the bayberry extract shifted the ZO-1-derived fluorescent signal histogram to the right. Furthermore, Figure 5 suggests that the bayberry extract locally accumulated ZO-1 expression levels, biasing the fluorescence intensity distribution. This local accumulation of ZO-1 expression is thought to indicate the formation of tight junctions. These results demonstrate that Bayberry extract can promote the formation of tight junctions. These results also demonstrate that Bayberry extract has the function of improving skin function.

[0104] (Evaluation of Skin Function Improvement Function in Human Monitor Test) A human monitor test on skin function improvement function was conducted on 13 healthy Japanese women (aged 29 to 51 years, average age 42.2 years) who gave their consent to the following test.

[0105] (Test conditions) <Sample> Bayberry leaf extract (a compound liquid prepared by diluting the Bayberry leaf extract prepared in the above "(Preparation of Bayberry Extract (Bayberry Leaf Extract))" with pure water (the compound liquid contains 1% of the prepared Bayberry leaf extract and 0.3% of 1,3-butylene glycol at a final concentration) Control (placebo): a compound liquid prepared by diluting 1,3-butylene glycol with pure water (the compound liquid contains 0.3% of 1,3-butylene glycol at a final concentration) <Test site> Designated areas on both left and right arms (inside of upper arms) <Sample application method> Twice a day (morning and night), take one drop of the sample and apply it directly to the test site (designated area) by rubbing it in with your finger

[0106] A comparative test was conducted on test sites before and after single use of the sample and four consecutive weeks of use to evaluate the stratum corneum moisture content. Measurement of stratum corneum moisture content was performed using a Corneometer (Courage+Khazaka electronic GmbH). For single use, stratum corneum moisture content was measured before application and 20 minutes after application. For four consecutive weeks of use, stratum corneum moisture content was measured before the first application (first day) and the day after the end of four weeks of application, at the same time as the measurement before the first application. Measurements were taken three times for each test site on the subject's upper arm, and the average value was used as the stratum corneum moisture content. Figure 6 shows the results of the human monitor test. Bayberry leaf extract demonstrated superior results in terms of stratum corneum moisture content compared to the control (placebo) in both single use and four consecutive weeks of use. This also clearly shows that bayberry extract can increase the skin's moisture retention ability and enhance the skin's moisturizing effect, in other words, it has the function of improving skin function.

Claims

1. A skin function improver containing bayberry extract as the active ingredient.

2. The skin function improving agent according to claim 1, which promotes the formation of tight junctions.

3. The skin function improving agent according to claim 1, which increases the expression of the claudin 1 gene.

4. The skin function improving agent according to claim 1, which increases the expression of the aquaporin 3 gene and the filaggrin gene.

5. A skin external preparation comprising the skin function improving agent according to any one of claims 1 to 4.

6. A cosmetic comprising the skin function improving agent according to any one of claims 1 to 4.

7. A skin function improving composition comprising the skin function improving agent according to any one of claims 1 to 4.

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