Hair composition, methods and uses thereof

Abstract

The present disclosure provides a composition and a method thereof for removing metals or metal buildup accumulated in the hair. The composition described herein comprises a chelator composition comprising at least one chelating agent and at least one foaming agent, which can further assist in mitigating the effects of metal buildup accumulated in the hair. The composition described herein can be formulated in various formats such as a form, a powder, or an aerosol. Further, provided herein are methods for removing metals from hair by using the composition and formats described herein.

Description

Attorney Docket No.63230-732.601 HAIR COMPOSITION, METHODS AND USES THEREOF CROSS-REFERENCE

[0001] This application claims the benefit of U.S. Provisional Application No.63 / 570,603 filed on March 27, 2024, which is incorporated herein by references in its entirety. BACKGROUND

[0002] Water hardness comes from dissolved salts of various metals including calcium (Ca2+) and magnesium (Mg2+). Hard water may also include trace metals. When hard water evaporates, the solid calcium carbonate CaCO3, also known as scale, is formed. Water hardness levels vary significantly across the country and internationally as well. Water hardness has adverse effects on the hair and directly impacts hair texture. SUMMARY

[0003] There is an unmet need for a safe and effective composition for removing metals from hair.

[0004] In one aspect, the present disclosure provides a composition for removing a metal from hair, comprising: a chelator composition comprising at least one chelating agent comprising trisodium dicarboxymethyl alaninate (trisodium MGDA), sodium phytate, sodium gluconate, tetrasodium glutamate diacetate, tetrasodium glutamate diacetate (tetrasodium GLDA), pentasodium pentetate, trisodium ethylenediamine succinate, sodium thiosulfate, caprylhydroxamic acid, diiospropyl oxalate, oxalic acid, potassium citrate, sodium citrate, or sodium oxalate, or a combination of two or more thereof; and at least one foaming agent; wherein the composition removes one or more metals from solution or hair of a subject.

[0005] In some instances, the at least one chelating agent binds to a primary metal, a secondary metal, or a combination thereof. In some instances, the at least one chelating agent binds a metal comprising calcium (Ca), magnesium (Mg), copper (Cu), iron (Fe), chromium (Cr), nickel (Ni), aluminum (Al), lead (Pb), zinc (Zn), cadmium (Cd), mercury (Hg), arsenic (As), barium (Ba), cobalt (Co), manganese (Mn), tin (Sn), tungsten (W), antimony (Sb), beryllium (Be), boron (B), bismuth (Bi), cesium (Ce), lithium (Li), molybdenum (Mo), selenium (Se), strontium (Sr), thallium (Tl), titanium (Ti), vanadium (V), scandium (Sc), gallium (Ga), yttrium (Y), niobium (Nb), technetium (Tc), ruthenium (Ru), rhodium (Rh), palladium (Pd), indium (In), tellurium (Te),Attorney Docket No.63230-732.601 rhenium (Rh), osmium (Os), iridium (Ir), or a combination thereof. In some instances, the at least one chelating agent binds a metal selected from the group consisting of: calcium, magnesium, copper, iron, chromium, nickel, aluminum, lead, zinc, cadmium, mercury, arsenic, or a combination thereof. In some instances, the chelator composition comprises at least 3 chelating agents. In some instances, the chelator composition comprises at least 4 chelating agents. In some instances, the at least one chelating agent comprises trisodium dicarboxymethyl alaninate (trisodium MGDA), sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamate diacetate (tetrasodium GLDA), pentasodium pentetate, trisodium ethylenediamine succinate, sodium thiosulfate, caprylhydroxamic acid, diisopropyl oxalate, oxalic acid, potassium citrate, sodium citrate, or sodium oxalate, or a combination thereof. In some instances, the at least one chelating agent comprises trisodium MGDA, sodium phytate, sodium gluconate, tetrasodium GLDA, diisopropyl oxalate, oxalic acid, potassium citrate, or a combination thereof. In some instances, the chelator composition is substantially free of ethylenediaminetetraacetic acid (EDTA).

[0006] In some instances, the composition is formulated as a foam. In some instances, the foaming agent comprises a surfactant, a copolymer, or a combination thereof. In some instances, the surfactant is an anionic surfactant, an amphoteric surfactant, a nonionic surfactant, or a combination thereof. In some instances, the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium xylenesulfonate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium 2-sulfolaurate, sodium myreth sulfate, sodium xylenesulfonate, sodium C14-16olefin sulfonate, sodium C14-16alpha olefin sulfonate, disodium lauryl sulfosuccinate, sodium methyl cocoyl taurate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, lauroyl sarcosine, cocoyl sarcosine, myristoyl sarcosine, oleoyl sarcosine, myristoyl / stearoyl sarcosine, sodium lauroyl glutamate, sodium cocoyl glutamate, disodium cocoyl glutamate, cocoyl glutamic acid, lauroyl glutamic acid, potassium cocoyl glutamate, potassium lauroyl glutamate, potassium myristoyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, disodium stearoyl glutamate, sodium palmitoyl glutamate, sodium lauroyl lactylate, sodium astrocaryum murumuruate, sodium laurylglucoside hydroxypropylsulfonate, disodium laurylglucoside hydroxypropyl citrate, sodium hydroxypropylsulfonate laurylglucoside crosspolymer, dioctyl sodium sulfosuccinate, or a combination thereof. In some instances, the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauryl betaine, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine,Attorney Docket No.63230-732.601 sodium dilauramidoglutamide lysine, sodium cocoamphopropionate, lauroamphoacetate, or a combination thereof. In some instances, the nonionic surfactant is decyl glucoside, lauryl glucoside, coco-glucoside, cocoyl methyl glucamide, capryloyl / caproyl methyl glucamide, lauroyl / myristoyl methyl glucamide, cocamidopropylamine oxide, decylamine oxide, or a combination thereof.

[0007] In some instances, the total concentration of the surfactant in the composition is about 0.1% (w / w) to about 90% (w / w), about 0.1% (w / w) to about 80% (w / w), about 0.1% (w / w) to about 70% (w / w), about 0.1% (w / w) to about 60% (w / w), about 0.1% (w / w) to about 50% (w / w), about 0.1% (w / w) to about 40% (w / w), or about 0.1% (w / w) to about 30% (w / w) of a total weight of the composition. In some instances, the total concentration of the surfactant in the foam is about 1% (w / w) to about 30% (w / w) of the total weight of the composition.

[0008] In some instances, the total concentration of the surfactant in the composition is about 5% (w / w) to about 20% (w / w) of the total weight of the composition. In some instances, the anionic surfactant has a net negative charge at a pH of about 4 to about 9. In some instances, the cationic surfactant has a net positive charge at a pH of about 4 to about 9.

[0009] In some instances, the surfactant comprises benzethonium chloride, betaine, cocamide diethanolamine, cocamidopropyl betaine, cocamidopropyl betaine (CAPB), cocamidopropyl hydroxysultaine, cocamidopropylamine oxide, coco-glucoside, decyl glucoside, decylamine oxide, dimyristoyl phosphatidylcholine, dipalmitoyl phosphatidylcholine, disodium cocoamphodiacetate, distearoyl phosphatidylcholine, hydrogenated starch hydrolysate, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauroyl sarcosine, lauryl betaine, lauryl glucoside, lauryl hydroxysultaine, maltooligosyl glucoside, potassium cocoyl hydrolyzed oat protein, sodium C14-16alpha olefin sulfonate, sodium C14-16olefin sulfonate, sodium cocoyl isethionate, sodium lauroyl glutamate, sodium lauroyl isethionate, sodium lauroyl sarcosinate, sodium methyl cocoyl taurate, sucrose glucoside, caprylyl / capryl glucoside, Starmella bombicola / brassica oil ferment, Sapindus mukorossi peel extract, sophorolipid, coconut extract, palm kernel extract, or a combination thereof. In some instances, the surfactant comprises a sophorolipid, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium lauroyl sarcosinate, sodium lauroyl isethionate, sodium cocoyl isethionate, lauroyl sarcosine, sodium lauroyl glutamate, sodium methyl cocoyl taurate, disodium cocoamphodiacetate, sodium C14-16 olefin sulfonate, sodium C14-16 alpha olefin sulfonate, cocamide diethanolamine, cocamidopropyl betaine (CAPB), cocobetaine, betaine, lauryl betaine, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, cocamidopropyl hydroxysultaine, dipalmitoyl phosphatidylcholine, dimyristoyl phosphatidylcholine, distearoyl phosphatidylcholine, or a combination thereof. In some instances, the surfactant comprises a saccharide comprising decyl glucoside, lauryl glucoside, coco-glucoside, maltooligosyl glucoside,Attorney Docket No.63230-732.601 hydrogenated starch hydrolysate, or a combination thereof. In some instances, the surfactant is selected from the group of Sapindus mukorossi peel extract, potassium cocoyl hydrolyzed oat protein, Starmella bombicola / brassica oil ferment, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium lauroyl sarcosinate, sodium lauroyl isethionate, sodium cocoyl isethionate, lauroyl sarcosine, sodium lauroyl glutamate, sodium methyl cocoyl taurate, disodium cocoamphodiacetate, sodium C14-16olefin sulfonate, sodium C14-16alpha olefin sulfonate, benzethonium chloride, cocamidopropylamine oxide, decylamine oxide, decyl glucoside, lauryl glucoside, coco-glucoside, cocamidopropyl betaine, betaine, lauryl betaine, lauramidopropyl hydroxysultaine, cocamidopropyl hydroxysultaine, maltooligosyl glucoside, hydrogenated starch hydrolysate, or a combination thereof. In some instances, the surfactant comprises polysorbate 20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, or a combination thereof. In some instances, the surfactant is present at a concentration of about 0.5% (w / w) to about 20% (w / w) of a total weight of the composition.

[0010] In some instances, the composition comprises a first surfactant and a second surfactant. In some instances, the first surfactant comprises Starmella bombicola / brassica oil ferment, Sapindus mukorossi peel extract, sophorolipid, coconut extract, or palm kernel extract, or a combination thereof. In some instances, the second surfactant comprises benzethonium chloride, betaine, cocamide diethanolamine, cocamidopropyl betaine, cocamidopropyl betaine (CAPB), cocamidopropyl hydroxysultaine, cocamidopropylamine oxide, coco-glucoside, decyl glucoside, decylamine oxide, dimyristoyl phosphatidylcholine, dipalmitoyl phosphatidylcholine, disodium cocoamphodiacetate, distearoyl phosphatidylcholine, hydrogenated starch hydrolysate, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauroyl sarcosine, lauryl betaine, lauryl glucoside, lauryl hydroxysultaine, maltooligosyl glucoside, potassium cocoyl hydrolyzed oat protein, sodium C14-16alpha olefin sulfonate, sodium C14-16olefin sulfonate, sodium cocoyl isethionate, sodium lauroyl glutamate, sodium lauroyl isethionate, sodium lauroyl sarcosinate, sodium methyl cocoyl taurate, sucrose glucoside, or caprylyl / capryl glucoside, or a combination thereof.

[0011] In some instances, the first surfactant is present at a concentration of about 0.5% (w / w) to about 5% (w / w) of a total weight of the composition. In some instances, the second surfactant is present at a concentration of about 5% (w / w) to about 20% (w / w) of a total weight of the composition. In some instances, the first surfactant and the second surfactant are present in a mass ratio of about 1:1, about 1:2, about 1:3, about 1:4, about 1:5, about 1:10, about 1:15, about 1:20, about 1:25, about 1:30, about 1:35 or about 1:40.Attorney Docket No.63230-732.601

[0012] In some instances, the composition described herein comprises an anti-redeposition agent comprises an anionic functionalized biopolymer having sequestering capacity. In some instances, the anti-redeposition agent forms a layer adjacent to a hair. In some instances, the at least one anti- redeposition agent comprises a polymer, or a silicate, or a combination thereof, wherein the polymer comprises a polypeptide, a polyacrylamide, a polyacrylamide / acrylamidopropyltrimonium copolymer, a polyquaternium, a polysaccharide, or a combination thereof. In some instances, the polypeptide comprises polyaspartate, polyglutamate, polyalanine, polyserine, polyarginine, or polylysine, or a combination thereof. In some instances, the polyquaternium comprises polyquaternium-2, polyquaternium-4, polyquaternium-7, polyquaternium-10, polyquaternium-17, polyquaternium-18, polyquaternium-24, polyquaternium-27, polyquaternium-28, polyquaternium- 32, polyquaternium,-33, polyquaternium-37, polyquaternium-55, polyquaternium-60, or polyquaternium-113, or a combination thereof. In some instances, the polysaccharide comprises sodium carboxymethyl inulin, xanthan gum, hydroxyethylcellulose, hydroxymethylcellulose, cellulose, cellulose gum, microcrystalline cellulose, carboxymethylcellulose, pullulan, sclerotium gum, tetragonoloba (guar) gum, acacia senegal gum, hydroxypropyl starch phosphate, or a combination thereof. In some instances, the silicate comprises lithium magnesium sodium silicate, sodium magnesium fluorosilicate, magnesium aluminum silicate, or a combination thereof.

[0013] In some instances, the at least one anti-redeposition agent comprises a polyacrylamide / acrylamidopropyltrimonium copolymer, polyaspartate, polyglutamate, polyalanine, polyserine, polyarginine, polylysine, polyquaternium-2, polyquaternium-4, polyquaternium-7, polyquaternium-10, polyquaternium-17, polyquaternium-18, polyquaternium-24, polyquaternium- 27, polyquaternium-28, polyquaternium-32, polyquaternium,-33, polyquaternium-37, polyquaternium-55, polyquaternium-60, or polyquaternium-113, sodium carboxymethyl inulin, xanthan gum, hydroxyethylcellulose, hydroxymethylcellulose, cellulose, cellulose gum, microcrystalline cellulose, carboxymethylcellulose, pullulan, sclerotium gum, tetragonoloba (guar) gum, acacia senegal gum, hydroxypropyl starch phosphate, lithium magnesium sodium silicate, sodium magnesium fluorosilicate, or a combination thereof. In some instances, the anti- redeposition agent is present at a concentration of about 1% (w / w) to about 5% (w / w) of a total weight of the composition.

[0014] In some instances, the anti-redeposition agent and the chelator composition are present in a mass ratio of about 1:2, about 1:5, about 1:10, about 1.5:2, about 1.5: 2.1, about 1.5: 2.2, about 1.5:2.3, about 1.5:2.4, about 1.5:2.5, about 1.5:2.6, about 1.5:2.7, about 1.5:2.8, about 1.5: 2.9, about 2:2.1, about 2:2.2, about 2:2.3, about 2:2.4, about 2:2.5, about 2:2.6, about 2:2.7, about 2:2.8, about 2:2.9, about 2:3, or about 2:5.Attorney Docket No.63230-732.601

[0015] In some instances, the composition further comprises a toning dye. In some instances, the toning dye comprises a purple dye, a blue dye, a green dye, a red dye, a yellow dye, an orange dye, or a combination thereof. In some instances, the toning dye is present at a concentration of about 0.1% (w / w) to about 20% (w / w) of a total weight of the composition.

[0016] In some instances, the composition comprises an antioxidant. In some instances, the antioxidant comprises carnosine, valine-cysteine, di-proline, di-phenylalanine, tocopherol, ascorbate, or a combination thereof. In some instances, the at least one antioxidant comprises carnosine, ascorbic acid, tetrahexyldecyl ascorbate, bioflavonoids, lycopene, Daucus carota sativa root cell culture lysate, monoammonium glycyrrhizinate, alpha lipoic acid (thioctic acid), Leontopodium alpinum (edelweiss) extract, Rosmarinus officinalis (rosemary) leaf extract, Vitis vinifera (grape) seed extract, Camellia sinensis leaf extract, Quercus robur wood extract, hydrolyzed olive fruit, Olea europea (olive) leaf extract, oleuropein, Punica granatum bark / fruit extract, punicalagin, ellagic acid, polyphenols, epigallocatechin (EGCG), tannins, sulforaphane, resveratrol, nordihydroguaiaretic acid, thioctic acid, or a combination thereof. In some instances, the total concentration (%w / w) of the at least one antioxidant in the composition is about 0.1% (w / w) to about 10% (w / w) of a total weight of the composition.

[0017] In some instances, the composition has a pH of about 5 to about 9. In some instances, the composition has a pH of about 7 to about 8. In some instances, the composition has a pH of about 5 to about 6.

[0018] In some instances, the composition described herein further comprises at least one pH modifier. In some instances, the at least one pH modifier comprises lactic acid, citric acid, malic acid, gluconic acid, glucuronic acid, glycolic acid, tartaric acid, azelaic acid, acetic acid, triethanolamine, L-arginine, or a conjugate base thereof, or a combination thereof. In some instances, the at least one pH modifier further comprises potassium hydroxide, sodium hydroxide, or both. In some instances, the at least one pH modifier has a pKaof about 4.0 to about 10.0.

[0019] In some instances, the total concentration (%w / w) of the at least one pH modifier in the composition is about 0.1% (w / w) to about 1% (w / w) of a total weight of the composition.

[0020] In some instances, the composition described herein further comprises at least one solvent. In some instances, the at least one solvent comprises a polar aprotic solvent, a polar protic solvent, a halocarbon solvent, or a combination thereof. In some instances, the polar aprotic solvent is dimethyl isosorbide, 1-methyl-2-pyrrolidone, 1-ethylpyrrolidin-2-one, N,N-dimethylacetamide, N- N-dimethylformamide (DMF), or a combination thereof. In some instances, the polar protic solvent comprises water, alcohol, glycol, or a combination thereof.Attorney Docket No.63230-732.601

[0021] In some instances, the alcohol comprises methanol, ethanol, propanol, isopropanol, isobutanol, triethyl citrate, or pantothenyl alcohol.

[0022] In some instances, the glycol is ethylene glycol, propane-1,2-glycol, propane-1,3-glycol, or a combination thereof.

[0023] In some instances, the halocarbon solvent comprises chlorotrifluoropropene.

[0024] In some instances, the composition described herein further comprises at least one cosmetically or dermatologically acceptable excipient, wherein the at least one dermatologically acceptable excipient comprises a detoxifying agent, a suspending agent, a perfume, a preservative, or a combination thereof. In some instances, the detoxifying agent comprises a clay, an acid, or a combination thereof. In some instances, the detoxifying agent comprises charcoal, bentonite clay, diatomite clay, kaolin clay, salicylic acid, ascorbic acid, glycolic acid, or a combination thereof.

[0025] In some instances, the suspending agent comprises an anionic polymer, nonionic polymer, or a combination thereof. In some instances, the suspending agent comprises carbomer, methyl cellulose, ethyl cellulose, nitrocellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder, polyvinylpyrrolidone, polyvinyl alcohol, guar gum, hydroxypropyl guar gum, arabia gum, galactan, carob gum, pectin, agar, quince seed (Cydonia oblonga Mill), starch (rice, corn, potato, wheat), algae colloid (algae extract), dextran, succinoglucan, pulleran, carboxymethyl starch, methylhydroxypropyl starch, sodium alginate, alginic acid propylene glycol ester, sodium polyacrylate, polyethylacrylate, polyacrylamide, polyethyleneimine, bentonite, aluminum magnesium silicate, laponite, hectonite, anhydrous silicic acid, or a combination thereof.

[0026] In some instances, the detoxifying agent is present at a concentration (% w / w) of about 0.1% (w / w) to about 1% (w / w) of a total weight of the composition. In some instances, the suspending agent is present at a concentration (% w / w) of about 0.1% (w / w) to about 1% (w / w) of a total weight of the composition.

[0027] In some instances, the composition described herein comprises a thickening agent. In some instances, the thickening agent increases a viscosity of the composition when dispersed or dissolved in water or a water-soluble solvent. In some instances, the thickening agent comprises a carboxylic acid polymer, a crosslinked polyacrylate polymer, a polyacrylamide polymer, a polysaccharide, a gum, or a combination thereof. In some instances, the carboxylic acid polymer comprises a carbomer, acrylic acid, substituted acrylic acid, or a salt or ester thereof, each monomer of the carboxylic acid polymer is connected via a double bond.

[0028] In some instances, the polysaccharide comprises an alkyl-substituted cellulose comprising methylcellulose, a hydroxyethylcellulose, a carboxymethylcellulose, or an acylated derivative thereof, or a combination thereof.Attorney Docket No.63230-732.601

[0029] In some instances, the gum comprises acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hectorite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, biosaccharide gum, or a combination thereof.

[0030] In some instances, the thickening agent comprises xanthan gum, guar gum, biosaccharide gum, cellulose, gum acacia, sclerotium gum, agarose, pectin, gellan gum, hyaluronic acid, or a combination thereof. In some instances, the thickening agent comprises polymeric thickening agents selected from the group consisting of ammonium polyacryloyldimethyl taurate, ammonium acryloyldimethyltaurate / vinylpyrrolidone copolymer, sodium polyacrylate, acrylate copolymer, polyacrylamide, carbomer, acrylate / C10-30 alkyl acrylate crosspolymer, acrylamide / sodium acryloyldimethyltaurate copolymer, or a combination thereof.

[0031] In some instances, the preservative comprises gluconolactone, benzyl alcohol, calcium gluconate, sodium benzoate, phenoxyethanol, potassium sorbate, ethylhexylglycerin, caprylyl glycol, caprylhydroxamic acid, or a combination thereof. In some instances, the preservative comprises benzoic acid, butyl paraben, diazolidinyl urea, DMDM hydantoin, ethyl paraben, imidazolidinyl urea, iodopropynyl butylcarbamate, isobutyl paraben, methyl paraben, methylchloroisothiazolinone, methylisothiazolinone, phenoxyethanol, propyl paraben, sodium benzoate, potassium sorbate, ethylhexylglycerin, gluconolactone, or a combination thereof.

[0032] In some instances, the composition has a viscosity of about 1 centipoise (cP) to about 60 cP. In some instances, the composition has a lather volume of about 1 cm3to about 10 cm3.

[0033] In some instances, the composition is dispensed using a foam dispenser.

[0034] In another aspect, the present disclosure provides a method for removing metals from hair, the method comprising using the composition described herein.

[0035] In one aspect, the present disclosure provides a method of decreasing metal deposition onto hair, the method comprising: administering to hair a composition comprising: a chelator composition; a surfactant; and an anti-redeposition polymer, wherein the anti-redeposition polymer forms a coating adjacent to the hair, thereby decreasing metal deposition onto hair. In some instances, the anti-redeposition agent comprises one or more functional groups having a net negative charge at a pH of about 4 to about 9, wherein the one or more functional groups chelates to a metal. In some instances, the method comprises administering a cleanser to the hair. In some instances, (i) administering the cleanser to the hair is prior to (ii) administering to hair theAttorney Docket No.63230-732.601 composition comprising a chelator composition, a surfactant, and a redeposition polymer. In some instances, (i) administering the cleanser to the hair is simultaneous with (ii) administering to hair the composition comprising a chelator composition, a surfactant, and a redeposition polymer.

[0036] In another aspect, the present disclosure provides a method of treating hair, wherein the method comprises: administering to hair a composition comprising: a chelator composition; and a toning dye, wherein the hair is bleached, as determined by measuring a E. In some instances, the E of hair treated with the composition is lower when compared to a E of hair not treated with the composition. In some instances, the E is about 0 to about 30.

[0037] Additional aspects and advantages of the present disclosure may become readily apparent to those skilled in this art from the following detailed description, wherein only illustrative embodiments of the present disclosure are shown and described. As may be realized, the present disclosure is capable of other and different embodiments, and its several details are capable of modifications in various obvious respects, all without departing from the disclosure. Accordingly, the drawings and description are to be regarded as illustrative in nature, and not as restrictive. BRIEF DESCRIPTION OF THE DRAWINGS

[0038] The novel features of the present disclosure are set forth with particularity in the appended claims. A better understanding of the features and advantages of the present disclosure will be obtained by reference to the following detailed description that sets forth illustrative embodiments, in which the principles of the present disclosure are utilized, and the accompanying drawings which:

[0039] FIG.1 shows the CIELAB system for measuring color, according to some embodiments of the present disclosure.

[0040] FIG. 2 shows delta a ( a) of hair during a treatment process involving 5 pool treatmentcycles, application of a composition comprising a chelator composition as described herein, and subsequent treatment steps, according to some embodiments of the present disclosure.

[0041] FIG.3 shows color change of cells 1 and 2 after soaking in contaminated hard water soak and bleach treatment, according to some embodiments of the present disclosure.

[0042] FIG.4 shows color change of cells 3 and 4 after soaking in contaminated hard water soak and color treatment, according to some embodiments of the present disclosure.Attorney Docket No.63230-732.601 DETAILED DESCRIPTION

[0043] Hard water has adverse effects on the hair and directly impacts hair texture. At high concentrations, the various metal salts in hard water are difficult to wash out completely, causing mineral buildup in the hair. The various metals in hard water may react with chemicals in hair cleansing / treatment products, making the products less effective. In some instances, the metals interfere with uniformity of a bleach / lightener or color service, leading to undesirable and streaky results. The mineral deposit buildup produced by the metals in hard water may combine with hair cleansing / treatment products to form contaminants that stick to the hair. Frequent washing with hard water may cause these minerals to build up, causing hair to have a rough and dry texture. The effects of the mineral deposit buildup can be exacerbated during chemical processing with peroxides in lightener, color, or perm services. Additionally, this mineral build up may cause the hair to look dull, have no shine, or appear hazy. In one aspect, provided herein is a composition, e.g., a hair demineralizer, for removing metals from hair comprising a chelator composition comprising at least one chelating agent. In another aspect, provided herein is a composition for removing metals from hair, comprising a chelator composition, at least one antioxidant, and at least one anti-redeposition agent. The chelator composition may comprise at least one chelating agent. In some instances, to provide diverse options for consumers, the composition described herein can be formulated in various formats comprising a foam, a cleanser, a conditioner, an emulsion, a gel, a paste, an aerosol, or a powder. In various aspects, the present disclosure provides a composition for removing metals from hair, comprising a chelator composition comprising at least one chelating agent, at least one antioxidant, and at least one anti-redeposition agent, wherein the composition is formulated as a foam, a cleanser, a conditioner, an emulsion, a gel, a paste, an aerosol, or a powder. The composition described herein may restore hair conditions or improve hair treatments by removing minerals in hair.

[0044] Water hardness comes from dissolved salts of various metals including, but not limited to, calcium (Ca2+) and magnesium (Mg2+). Exemplary forms of these salts include, but are not limited to, bicarbonates (e.g., Ca(HCO3)2 or Mg(HCO3)2), sulfates (e.g., CaSO4 or MgSO4), and chlorides (e.g., CaCl2 or MgCl2). When hard water evaporates, solid calcium carbonate (CaCO3), also known as scale, is formed. Water hardness levels are usually reported in grains per gallon (gpg), parts per million (ppm), or milligrams per liter (mg / L). Table 1 shows the water hardness levels and their representative concentrations.Attorney Docket No.63230-732.601 Table 1. Water Hardness Levels

[0045] Water hardness levels vary significantly across the country and internationally. For example, Portugal has naturally soft water, while the UK has super hard water. Hardness exceeds 450 ppm (26 gpg) in certain regions of the Middle East.

[0046] In tap water (both hard and soft), trace metals are also present at lower levels. In some cases, the amount of trace metals is 10 to 100 times less than the amounts of Mg2+and Ca2+. A nonlimiting example of trace metals includes iron (Fe), copper (Cu), zinc (Zn), aluminum (Al), lead (Pb), nickel (Ni), cadmium (Cd), chromium (Cr), mercury (Hg), arsenic (As), barium (Ba), cobalt (Co), manganese (Mn), tin (Sn), tungsten (W), antimony (Sb), beryllium (Be), boron (B), bismuth (Bi), cesium (Cs), lithium (Li), molybdenum (Mo), selenium (Se), strontium (Sr), thallium (Tl), titanium (Ti), vanadium (V), scandium (Sc), gallium (Ga), yttrium (Y), niobium (Nb), technetium (Tc), ruthenium (Ru), rhodium (Rh), palladium (Pd), indium (In), tellurium (Te), rhenium (Re), osmium (Os), and iridium (Ir). The elements on the edges of the Periodic Table, particularly metals of groups IA and IIA, prefer specific charges (e.g., ionized Ca and Mg tend to carry a positive charge of 2+), while those in the middle, of groups IB-VIIB also known as the transition metals, can hold different charges (e.g., Fe2+, Fe3+, Fe4+, and Fe6+). As a result, these transition metals can be involved in various redox (oxidative-reductive) reactions.

[0047] Trace metals are found from sources other than water. Some of them play important biological roles as macro minerals. These metals include, but are not limited to, Ca, Mg, Fe, Cu, and Zn. Metals that are used or absorbed by the body may be removed in the hair formation process, where the metals end up inside hair fibers. Metal content in hair is an indicator of biological levels and, in some instances, hair is used in forensics to monitor environmental exposure to heavy metals. In some cases, metals are found in consumer products. Exemplary types of these metals include, but are not limited to, Cd, Ni, Pd, Fe, Cu, and Al. In some cases, metals are found in pollution. Exemplary of these metals include, but are not limited to, Hg, Pb, Cd, and Al from cigarette smoke.Attorney Docket No.63230-732.601

[0048] Hair proteins naturally carry a net negative charge. In some cases, alkaline conditions and oxidative damage increase negative charges on hair, resulting in the potential for increased metal buildup because positively charged metal ions in water are attracted to and bind with the negatively charged hair proteins. These metals include Ca2+, Mg2+, and trace metal ions, from hard and soft water. In some instances, sulfur-containing amino acids (e.g., cysteine, methionine) act as binding sites for metal ions. When disulfide bonds are cleaved by chemical treatments, for example, perm treatment, free thiols are formed which bind the metal ions. In some instances, cysteic acid, which is an indicator of the level of damage of hair, is formed by oxidative chemical treatments of hair by forming additional binding sites for metal ions. Alkaline conditions may be encountered easily, as the average pH for household tap water in the US ranges from 6.5-9.5 and the majority of chemical treatments are performed at pH greater than 10, in cases some exceeding 12.

[0049] Depending on water source and quality, several factors may influence the binding of metals to hair. In some embodiments, the factors comprise pH, size of metal ion, concentration of metal ion, other metal ions present, state of metal ions (e.g., complexed salt or free form), and the condition of the hair. A general trend of binding affinity of metals to hair is Zn2+> Fe2+> Hg2+> Cu2+> Pb2+> Cr3+> Cd2+> Ni2+>Al2+. Additionally, hair has an affinity for heavy metals, which can damage hair, and using hair as an alternative material for heavy metal decontamination of aqueous media has been proposed and studied.

[0050] The metal ions in hard water directly affect the texture of hair. For example, the metal ions create mineral buildup that interferes with hair cleansing and / or treatment and general manageability. As a result, the hair looks dull and has no shine, appears hazy and has a rough texture, or is dry and brittle. In some instances, metals interfere with uniformity of a bleach / lightener or color treatment, leading to undesirable and streaky results. In some instances, metal ions change the way various products sit on or interact with hair. In some cases, trace metal ions cause more significant damage. In some cases, trace metal ions catalyze oxidative reactions, further amplifying the incidental damage to hair by oxidative chemicals. In some cases, the effects of trace metal ions are exacerbated by sunlight (UV), atmospheric oxygen, pollution, or during chemical processing with peroxides in lightener, color, or perm services. In some instances, during the hair chemical treatment process, trace metal ions cause uneven and unpredictable color, smoking foils, or hair break-off. In some cases, metals alter or fade the color of hair. For example, a swimmer’s green hair is a two-fold problem. Contrary to popular belief, the problem is not due to chlorine itself but to the presence of Cu2+ions in the hair which impart the blue-green color. Chlorine, the active chemical in pool disinfectants, acts as a strong oxidizer which oxidizes the proteins in hair, increasing their ability to bind Cu2+ions. Further exposure to UV light, such as forAttorney Docket No.63230-732.601 example swimming outdoors, increases the damage and subsequently the number of negative charges in the hair, causing more Cu2+to bind to the hair intensifying the greenish color of the hair.

[0051] Accordingly, to meet the unmet need for a safe and effective composition for removing metals from hair, in one aspect, the present disclosure provides a composition for removing metals from hair. In some instances, the composition for removing a metal from hair comprises a chelator composition comprising at least one chelating agent, and at least one foaming agent, wherein the composition removes one or more metals from solution or hair of a subject. In some instances, the composition further comprises at least one antioxidant. In some embodiments, the composition further comprises at least one anti-redeposition agent. In some embodiments, the composition described herein can be formulated as a foam, a cleanser, a conditioner, an emulsion, a gel, a paste, an aerosol, or a powder. In some instances, the composition described herein can be used to remove metals from hair, which can effectively bind the various metal ions found in hard water including, but not limited to, calcium (Ca), magnesium (Mg), copper (Cu), iron (Fe), chromium (Cr), nickel (Ni), aluminum (Al), lead (Pb), zinc (Zn), cadmium (Cd), mercury (Hg), arsenic (As), barium (Ba), cobalt (Co), manganese (Mn), tin (Sn), tungsten (W), antimony (Sb), beryllium (Be), boron (B), bismuth (Bi), cesium (Cs), lithium (Li), molybdenum (Mo), selenium (Se), strontium (Sr), thallium (Tl), titanium (Ti), vanadium (V), scandium (Sc), gallium (Ga), yttrium (Y), niobium (Nb), technetium (Tc), ruthenium (Ru), rhodium (Rh), palladium (Pd), indium (In), tellurium (Te), rhenium (Re), osmium (Os), iridium (Ir), or a combination thereof. DEFINITIONS

[0052] Unless defined otherwise, all terms of art, notations, and other technical and scientific terms or terminology used herein are intended to have the same meaning as is commonly understood by one of ordinary skill in the art to which the claimed subject matter pertains. In some cases, terms with commonly understood meanings are defined herein for clarity and / or for ready reference, and the inclusion of such definitions herein should not necessarily be construed to represent a substantial difference over what is generally understood in the art.

[0053] Throughout this disclosure, various embodiments may be presented in a range format. It should be understood that the description in range format is merely for convenience and brevity and should not be construed as an inflexible limitation on the scope of the disclosure. Accordingly, the description of a range should be considered to have specifically disclosed all the possible subranges as well as individual numerical values within that range. For example, a description of a range such as from 1 to 6 should be considered to have specifically disclosed subranges such as from 1 to 3, from 1 to 4, from 1 to 5, from 2 to 4, from 2 to 6, from 3 to 6, etc., as well as individual numbersAttorney Docket No.63230-732.601 within that range, for example, 1, 2, 3, 4, 5, and 6. This applies regardless of the breadth of the range.

[0054] As used herein, the terms “composition”, “hair composition”, and “hair demineralizer composition” are used interchangeably.

[0055] As used herein, the singular forms “a”, “an” and “the” include plural references unless the context clearly dictates otherwise. For example, the term “a sample” includes a plurality of samples, including mixtures thereof.

[0056] As used herein, the terms “determining,” “measuring,” “evaluating,” “assessing,” “assaying,” and “analyzing” are often used interchangeably herein to refer to forms of measurement. The terms include determining if an element is present or not (for example, detection). These terms can include quantitative, qualitative or both quantitative and qualitative determinations. The term “assessing” can be relative or absolute. “Detecting the presence of” can include determining the amount of something present in addition to determining whether it is present or absent depending on the context.

[0057] As used herein, the term “about” or “approximately” when referring to a measurable value such as an amount or concentration and the like, is meant to encompass variations of 20%, 10%, 5%, 1%, 0.5%, or 0.1% of the specified amount. In some instances, the term “about” includes the value itself. For example, “about” can mean plus or minus 10%, per the practice in the art. Alternatively, “about” can mean a range of plus or minus (±) 20%, plus or minus 10%, plus or minus 5%, or plus or minus 1% of a given value. Alternatively, particularly with respect to biological systems or processes, the term can mean within an order of magnitude, up to 5-fold, or up to 2-fold, of a value. Where particular values can be described in the application and claims, unless otherwise stated the term “about” may be assumed to encompass the acceptable error range for the particular value. Also, where ranges, subranges, or both, of values can be provided, the ranges or subranges can include the endpoints of the ranges or subranges. Where values are described as ranges, it may be understood that such disclosure includes the disclosure of all possible sub-ranges within such ranges, as well as specific numerical values that fall within such ranges irrespective of whether a specific numerical value or specific sub-range is expressly stated.

[0058] As used herein, the terms “comprise,” “have,” and “include” are open-ended linking verbs. Any forms or tenses of one or more of these verbs, such as “comprises,” “comprising,” “has,” “having,” “includes,” and “including,” are also open-ended. For example, any method that “comprises,” “has,” or “includes” one or more steps is not limited to possessing only those one or more steps and also covers other unlisted steps.Attorney Docket No.63230-732.601

[0059] As used herein, the term “mixture” or “mixtures” is meant to include a simple combination of materials and any compounds that may result from their combination.

[0060] As used herein, the term “cosmetically acceptable” refers to those compounds, materials, compositions, and / or dosage forms that are, within the scope of sound medical judgment, suitable for use in contact with the tissues of human beings and animals without excessive toxicity, irritation, allergic response, or other problems or complications commensurate with a reasonable benefit / risk ratio.

[0061] As used herein, the term “cosmetically or dermatologically acceptable” refers to the compositions or components described that are suitable for use in contact with human skin tissue without undue toxicity, incompatibility, instability, allergic response, and the like.

[0062] As used herein, the terms “metal” and “metal ion” are used interchangeably to refer to an element of the Periodic Table of elements. Reference to a metal includes the different valences or oxidation state(s) of the metal. In some embodiments, for example, iron may refer to Fe, and may also refer to Fe+, Fe2+, Fe3+, Fe4+, or a mixture of Fe in its various oxidation states. For example, reference to Fe may include a mixture of Fe2+and Fe4+, a mixture of Fe2+and Fe3+, or a mixture of Fe2+, Fe3+, Fe4+, and so forth.

[0063] As used herein the term “substantially” refers to a given parameter, property, or condition means and includes to a degree that one of ordinary skill in the art would understand that the given parameter, property, or condition is met with a degree of variance, such as within acceptable manufacturing tolerances. By way of example, depending on the particular parameter, property, or condition that is substantially met, the parameter, property, or condition may be at least 90.0% met, at least 95.0% met, at least 99.0% met, or even at least 99.9% met.

[0064] The section headings used herein are for organizational purposes only and are not to be construed as limiting the subject matter described. COMPOSITION FOR REMOVING METALS FROM HAIR

[0065] In one aspect, provided herein is a composition for safely removing various metal ions found in water from the hair. In some instances, the composition for removing various metals or metal ions found in water from the hair refers to hair demineralizer or hair demineralizer composition, and these terms can be used interchangeably. In some instances, the composition for removing metals from hair as described herein comprises a chelator composition comprising at least one chelating agent. In some instances, the composition for removing metals from hair as described herein comprises a chelator composition comprising at least one chelating agent, at least one antioxidant, and at least one anti-redeposition agent. In some instances, the composition forAttorney Docket No.63230-732.601 removing metals from hair as described herein comprises a chelator composition comprising at least one chelating agent, at least one antioxidant, and at least one anti-redeposition agent, and the composition is formulated as a foam, a cleanser, a conditioner, an emulsion, a gel, a paste, an aerosol, or a powder.

[0066] In another aspect, provided herein is a composition for removing a metal from hair, and the composition comprises a chelator composition and at least one foaming agent. In some embodiments, provided herein is a composition for decreasing metal deposition onto hair, the composition comprising a chelator composition; a surfactant; and an anti-redeposition polymer. In various aspects, provided herein is a composition for treating hair, the composition comprising a chelator composition; and a toning dye.

[0067] In some embodiments, the composition for removing metals from hair as described herein comprises a chelator composition comprising at least one chelating agent, at least one antioxidant, and at least one anti-redeposition agent. In some embodiments, the composition for removing metals from hair as described herein comprises a chelator composition comprising at least one chelating agent, at least one antioxidant, at least one anti-redeposition agent, and at least one surfactant. In some embodiments, the composition for removing metals from hair as described herein comprises a chelator composition, at least one antioxidant, at least one anti-redeposition agent, and at least one pH modifier, wherein the chelator composition comprises at least one chelating agent. In some embodiments, the composition for removing metals from hair as described herein comprises a chelator composition, at least one antioxidant, at least one anti-redeposition agent, and at least one solvent, wherein the chelator composition comprises at least one chelating agent. In some embodiments, the composition for removing metals from hair as described herein comprises a chelator composition, at least one antioxidant, at least one anti-redeposition agent, at least one surfactant, and at least one pH modifier, wherein the chelator composition comprises at least one chelating agent. In some embodiments, the composition for removing metals from hair as described herein comprises a chelator composition, at least one antioxidant, at least one anti- redeposition agent, at least one surfactant, and at least one solvent, wherein the chelator composition comprises at least one chelating agent. In some embodiments, the composition for removing metals from hair as described herein comprises a chelator composition comprising, at least one antioxidant, at least one anti-redeposition agent, at least one pH modifier, and at least one solvent, wherein the chelator composition comprises at least one chelating agent. In some embodiments, the composition for removing metals from hair as described herein comprises a chelator composition, at least one antioxidant, at least one anti-redeposition agent, at least one surfactant, at least one pH modifier, and at least one solvent, wherein the chelator compositionAttorney Docket No.63230-732.601 comprises at least one chelating agent. In some embodiments, the composition for removing metals from hair as described herein comprises a chelator composition, at least one antioxidant, at least one anti-redeposition agent, at least one surfactant, at least one pH modifier, at least one solvent, and at least one cosmetically or dermatologically acceptable excipient, wherein the chelator composition comprises at least one chelating agent.

[0068] In some embodiments, the composition for removing metals from hair as described herein comprises a pH of about 6 to about 9. In some embodiments, the composition for removing metals from hair as described herein comprises a pH of about 6 to about 8. In some embodiments, the composition for removing metals from hair as described herein comprises a pH of about 7 to about 9. In some embodiments, the composition for removing metals from hair as described herein comprises a pH of about 7 to about 8. In some embodiments, the composition for removing metals from hair as described herein described herein comprises a pH of about 5, about 5.5, about 6, about 6.5, about 7, about 7.5, about 8, about 8.5, about 9, or about 9.5. In some embodiments, the composition for removing metals from hair as described herein comprises a pH of at least 5, at least 5.5, at least 6, at least 6.5, at least 7, at least 7.5, at least 8, at least 8.5, at least 9, or at least 9.5. In some embodiments, the composition for removing metals from hair as described herein comprises a pH of at most 5, at most 5.5, at most 6, at most 6.5, at most 7, at most 7.5, at most 8, at most 8.5, at most 9, or at most 9.5. In some embodiments, the composition for removing metals from hair as described herein has a pH of about 7 to about 8.

[0069] In some embodiments, the composition for removing metals from hair as described herein comprises a formulation selected from any one of Table 5, Table 6, Table 7, Table 8, Table 11, Table 12, Table 13, Table 14, Table 15, Table 16, Table 17, Table 18, Table 19, Table 20, Table 21, Table 22, Table 23, Table 24, Table 25, Table 26, Table 27, Table 28, Table 29, Table 30, Table 31, Table 32, Table 33, Table 34, Table 35, Table 36, Table 37, Table 38, Table 39, Table 40, or Table 41. Chelator Composition

[0070] In another aspect, provided herein is a composition for removing a metal from hair, and the composition comprises a chelator composition and at least one foaming agent. In some instances, the chelator composition comprises at least one chelating agent. In some instances, the at leaset one chelating agent comprising trisodium dicarboxymethyl alaninate (trisodium MGDA), sodium phytate, sodium gluconate, tetrasodium glutamate diacetate, tetrasodium glutamate diacetate (tetrasodium GLDA), ethylenediaminetetraacetic acid (EDTA), pentasodium pentetate, trisodium ethylenediamine succinate, sodium thiosulfate, caprylhydroxamic acid, diiospropyl oxalate, oxalic acid, potassium citrate, sodium citrate, or sodium oxalate, or a combination of two or more thereof.Attorney Docket No.63230-732.601 In some embodiments, the composition for removing metal from hair comprises a chelator composition comprising at least one chelating agent comprising trisodium dicarboxymethyl alaninate (trisodium MGDA), sodium phytate, sodium gluconate, tetrasodium glutamate diacetate, tetrasodium glutamate diacetate (tetrasodium GLDA), pentasodium pentetate, trisodium ethylenediamine succinate, sodium thiosulfate, caprylhydroxamic acid, diiospropyl oxalate, oxalic acid, potassium citrate, sodium citrate, or sodium oxalate, or a combination of two or more thereof; and at least one foaming agent; and wherein the composition removes one or more metals from solution or hair of a subject.

[0071] In some embodiments, a chelator composition comprises at least one chelating agent. In some instances, chelating agent refers to agents or substances that form a stable, water-soluble complex by binding tightly to metal ions. They are also known as chelants or chelators, and these terms are used interchangeably herein. In some instances, the at least one chelating agent can target and bind with the primary metals found in hard water. Primary metals directly impact the hair fiber texture, appearance, and structural integrity. Additionally, primary metals limit the ability of various molecules and compounds to penetrate the hair to resulting in the reduction of the efficacy of certain hair treatments. In some embodiments, the primary metals comprise calcium (Ca) and magnesium (Mg).

[0072] In some instances, the at least one chelating agent described herein can also target and bind with secondary metals (trace metals) found in hard water. These secondary metals increase oxidation reactions at the surface and interior of the hair which may alter chemical treatments and increase the potential for damage to the hair during chemical treatments. In some embodiments, the secondary metals comprise copper (Cu), iron (Fe), chromium (Cr), nickel (Ni), aluminum (Al), lead (Pb), zinc (Zn), cadmium (Cd), mercury (Hg), arsenic (As), barium (Ba), cobalt (Co), manganese (Mn), tin (Sn), tungsten (W), antimony (Sb), beryllium (Be), boron (B), bismuth (Bi), cesium (Cs), lithium (Li), molybdenum (Mo), selenium (Se), strontium (Sr), thallium (Tl), titanium (Ti), vanadium (V), scandium (Sc), gallium (Ga), yttrium (Y), niobium (Nb), technetium (Tc), ruthenium (Ru), rhodium (Rh), palladium (Pd), indium (In), tellurium (Te), rhenium (Re), osmium (Os), iridium (Ir), or a combination thereof. In some embodiments, the at least one chelating agent binds to a primary metal, a secondary metal, or a combination thereof.

[0073] In some embodiments, the at least one chelating agent binds to a primary metal, a secondary metal, or a combination thereof. In some embodiments, the at least one chelating agent binds a metal comprising calcium (Ca), magnesium (Mg), copper (Cu), iron (Fe), chromium (Cr), nickel (Ni), aluminum (Al), lead (Pb), zinc (Zn), cadmium (Cd), mercury (Hg), arsenic (As), barium (Ba), cobalt (Co), manganese (Mn), tin (Sn), tungsten (W), antimony (Sb), beryllium (Be), boron (B),Attorney Docket No.63230-732.601 bismuth (Bi), cesium (Ce), lithium (Li), molybdenum (Mo), selenium (Se), strontium (Sr), thallium (Tl), titanium (Ti), vanadium (V), scandium (Sc), gallium (Ga), yttrium (Y), niobium (Nb), technetium (Tc), ruthenium (Ru), rhodium (Rh), palladium (Pd), indium (In), tellurium (Te), rhenium (Rh), osmium (Os), iridium (Ir), or a combination thereof. In some embodiments, the at least one chelating agent binds a metal selected from the group consisting of: calcium, magnesium, copper, iron, chromium, nickel, aluminum, lead, zinc, cadmium, mercury, arsenic, or a combination thereof.

[0074] In some embodiments, the at least one chelating agent bind metal ions by forming a molecular cage around the metal ions. In some embodiments, the at least one chelating agent forms at least two bonds with the metal or metal ion. In some embodiments, the at least one chelating agent coordinates to at least two sites on a metal or metal ion.

[0075] In some embodiments, the at least one chelating agent comprises a sequestrant. In some embodiments, the sequestrant forms at least one bond with the metal or metal ion. In some embodiments, the sequestrant coordinates to at least one site on a metal or metal ion. In some embodiments, the at least one chelating agent comprises a chelator, a sequestrant, or a combination thereof. In some embodiments, the at least one chelating agent is a chelator or sequestrant.

[0076] In some embodiments, the at least one chelating agent bind irreversibly with metal ions. In some embodiments, the at least one chelating agent binds to a metal ion that is described by an affinity constant, such as the dissociation constant (KD). The dissociation constant is defined as the ratio of the product of the unbound chelator and unbound metal ion to the complex chelator and metal ion, and is expressed in units of concentration, such as mols / liter (L). In some embodiments, the at least one chelating agent binds to a metal ion irreversibly, and the KDof the reaction may be less than about 1×10-7M. In some instances, the at least one chelating agent binds to the metal ion with a KDof about 10×10-9M, about 9×10-9M, about 8×10-9M, about 7×10-9M, about 6×10-9M, about 5×10-9M, about 4×10-9M, about 3×10-9M, about 2×10-9M, about 1×10-9M, 10×10-8M, about 9×10-8M, about 8×10-8M, about 7×10-8M, about 6×10-8M, about 5×10-8M, about 4×10-8M, about 3×10-8M, about 2×10-8M, about 1×10-8M, 10×10-7M, about 9×10-7M, about 8×10-7M, about 7×10-7M, about 6×10-7M, about 5×10-7M, about 4×10-7M, about 3×10-7M, about 2×10-7M, about 1×10-7M, 10×10-6M, about 9×10-6M, about 8×10-6M, about 7×10-6M, about 6×10-6M, about 5×10-6M, about 4×10-6M, about 3×10-6M, about 2×10-6M, about 1×10-6M, 10×10-5M, about 9×10-5M, about 8×10-5M, about 7×10-5M, about 6×10-5M, about 5×10-5M, about 4×10-5M, about 3×10-5M, about 2×10-5M, or about 1×10-5M.

[0077] In some embodiments, the chelator composition comprises at least one chelating agent. In some embodiments, the chelator composition comprises at least two chelating agents. In someAttorney Docket No.63230-732.601 embodiments, the chelator composition comprises at least three chelating agents. In some embodiments, the chelator composition comprises at least four chelating agents. In some embodiments, the chelator composition comprises at least five chelating agents. In some embodiments, the chelator composition comprises at least six chelating agents. In some embodiments, the chelator composition comprises at least seven chelating agents. In some embodiments, the chelator composition comprises at least eight chelating agents. In some embodiments, the chelator composition comprises at least nine chelating agents. In some embodiments, the chelator composition described herein comprises a plurality of chelating agents that work synergistically to prevent and remove mineral buildup accumulated in the hair.

[0078] In some instances, the at least one chelating agent comprises one chelating agent, two chelating agents, three chelating agents, four chelating agents, five chelating agents, six chelating agents, seven chelating agents, eight chelating agents, nine chelating agents, ten chelating agents, eleven chelating agents, or twelve chelating agents. In some instances, the at least one chelating agent comprises at least one chelating agent, at least two chelating agents, at least three chelating agents, at least four chelating agents, at least five chelating agents, at least six chelating agents, at least seven chelating agents, at least eight chelating agents, at least nine chelating agents, at least ten chelating agents, at least eleven chelating agents, or at least twelve chelating agents. In some instances, the at least one chelating agent comprises at least two chelating agents.

[0079] In some embodiments, the at least one chelating agent comprises ethylenediaminetetraacetic acid (EDTA) or salt thereof. In some instances, the at least one chelating agent comprises ethylenediaminetetraacetic acid (EDTA) or tetrasodium ethylenediaminetetraacetic acid (tetrasodium EDTA). In some embodiments, the at least one chelating agent comprises ethylenediaminetetraacetic acid (EDTA), tetrasodium ethylenediaminetetraacetic acid (tetrasodium EDTA), sodium phytate, phytic acid, or a combination thereof. In some embodiments, the at least one chelating agent comprises ethylenediaminetetraacetic acid (EDTA), tetrasodium ethylenediaminetetraacetic acid (tetrasodium EDTA), sodium phytate, phytic acid, sodium gluconate, or a combination thereof. In some embodiments, the at least one chelating agent comprises ethylenediaminetetraacetic acid (EDTA), tetrasodium ethylenediaminetetraacetic acid (tetrasodium EDTA), trisodium dicarboxymethyl alaninate (trisodium MGDA), tetrasodium glutamate diacetate (tetrasodium GLDA), or a combination thereof. In some embodiments, the at least one chelating agent comprises tetrasodium EDTA, sodium phytate, phytic acid, sodium gluconate, trisodium dicarboxymethyl alaninate (trisodium MGDA), or a combination thereof. In some embodiments, the at least one chelating agent comprises sodium phytate, sodium gluconate, trisodium dicarboxymethyl alaninate (trisodium MGDA), or a combination thereof. In someAttorney Docket No.63230-732.601 embodiments, the at least one chelating agent comprises tetrasodium EDTA, sodium gluconate, trisodium dicarboxymethyl alaninate (trisodium MGDA), tetrasodium GLDA, or a combination thereof. In some embodiments, the at least one chelating agent comprises tetrasodium EDTA, sodium phytate, sodium gluconate, trisodium dicarboxymethyl alaninate (trisodium MGDA), tetrasodium GLDA, or a combination thereof. In some embodiments, the at least one chelating agent comprises tetrasodium EDTA, sodium phytate, phytic acid, sodium gluconate, trisodium dicarboxymethyl alaninate (trisodium MGDA), tetrasodium GLDA, or a combination thereof. In some embodiments, the at least one chelating agent comprises tetrasodium EDTA, sodium phytate, phytic acid, sodium gluconate, trisodium dicarboxymethyl alaninate (trisodium MGDA), tetrasodium GLDA, or a combination thereof. Non-limiting examples of the chelating agents include, but are not limited to, trisodium dicarboxymethyl alaninate (trisodium MGDA), sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamate diacetate (tetrasodium GLDA), tetrasodium ethylenediaminetetraacetic acid (tetrasodium EDTA), ethylenediaminetetraacetic acid (EDTA), trisodium EDTA, disodium EDTA, pentasodium pentetate, trisodium ethylenediamine succinate, sodium thiosulfate, caprylhydroxamic acid, diisopropyl oxalate, disodium EDTA-copper, hydroxyethylethylenediaminetriacetic acid (HEDTA), oxalic acid, potassium citrate, sodium citrate, sodium oxalate, tris(2-hydroxyethyl)ammonium trihydrogen ethylenediaminetetraacetate (TEA- EDTA), trisodium HEDTA, or a combination thereof. In some embodiments, the at least one chelating agent comprises trisodium dicarboxymethyl alaninate (trisodium MGDA), sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamate diacetate (tetrasodium GLDA), tetrasodium ethylenediaminetetraacetic acid (tetrasodium EDTA), trisodium EDTA, disodium EDTA, pentasodium pentetate, trisodium ethylenediamine succinate, sodium thiosulfate, caprylhydroxamic acid, diiospropyl oxalate, disodium EDTA-copper, hydroxyethylethylenediaminetriacetic acid (HEDTA), oxalic acid, potassium citrate, sodium citrate, sodium oxalate, tris(2-hydroxyethyl)ammonium trihydrogen ethylenediaminetetraacetate (TEA- EDTA), trisodium HEDTA, or a combination thereof. In some embodiments, the at least one chelating agent comprises trisodium MGDA, sodium phytate, sodium gluconate, tetrasodium GLDA, tetrasodium EDTA, or a combination thereof.

[0080] In some embodiments, the at least one chelating agent comprises at least two chelating agents. In some embodiments, the at least two chelating agents comprise ethylenediaminetetraacetic acid (EDTA) or salt thereof. In some instances, the at least two chelating agents comprise ethylenediaminetetraacetic acid (EDTA) or tetrasodium ethylenediaminetetraacetic acid (tetrasodium EDTA). In some embodiments, the at least two chelating agents comprise trisodium dicarboxymethyl alaninate (trisodium MGDA), sodiumAttorney Docket No.63230-732.601 phytate, phytic acid, sodium gluconate, tetrasodium glutamate diacetate (tetrasodium GLDA), tetrasodium ethylenediaminetetraacetic acid (tetrasodium EDTA), trisodium EDTA, disodium EDTA, pentasodium pentetate, trisodium ethylenediamine succinate, sodium thiosulfate, caprylhydroxamic acid, diiospropyl oxalate, disodium EDTA-copper, Hydroxyethylethylenediaminetriacetic acid (HEDTA), oxalic acid, potassium citrate, sodium citrate, sodium oxalate, tris(2-hydroxyethyl)ammonium trihydrogen ethylenediaminetetraacetate (TEA-EDTA), trisodium HEDTA, or a combination thereof. In some embodiments, the at least two chelating agents comprise trisodium MGDA and sodium phytate. In some embodiments, the at least two chelating agents comprise trisodium MGDA and phytic acid. In some embodiments, the at least two chelating agents comprise trisodium MGDA and sodium gluconate. In some embodiments, the at least two chelating agents comprise trisodium MGDA and tetrasodium GLDA. In some embodiments, the at least two chelating agents comprise trisodium MGDA and one of tetrasodium GLDA, tetrasodium EDTA, trisodium EDTA, or disodium EDTA. In some embodiments, the at least two chelating agents comprise trisodium MGDA and tetrasodium EDTA. In some embodiments, the at least two chelating agents comprise trisodium MGDA and pentasodium pentetate. In some embodiments, the at least two chelating agents comprise tetrasodium EDTA and tetrasodium GLDA. In some embodiments, the at least two chelating agents comprise disodium EDTA and tetrasodium EDTA. In some embodiments, the at least two chelating agents comprise disodium EDTA and trisodium ethylenediamine succinate. In some embodiments, the at least two chelating agents comprise trisodium MGDA and sodium thiosulfate. In some embodiments, the at least two chelating agents comprise trisodium MGDA and caprylhydroxamic acid. In some embodiments, the at least two chelating agents comprise trisodium MGDA, sodium phytate, sodium gluconate, tetrasodium GLDA, tetrasodium EDTA, or a combination thereof.

[0081] In some embodiments, the at least one chelating agent comprises at least three chelating agents. In some embodiments, the at least three chelating agents comprise ethylenediaminetetraacetic acid (EDTA) or salt thereof. In some instances, the at least three chelating agents comprise ethylenediaminetetraacetic acid (EDTA) or tetrasodium ethylenediaminetetraacetic acid (tetrasodium EDTA). In some embodiments, the at least three chelating agents comprise trisodium MGDA and at least two chelators comprising sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamate diacetate (tetrasodium GLDA), tetrasodium ethylenediaminetetraacetic acid (EDTA), trisodium EDTA, disodium EDTA, trisodium ethylenediamine succinate, sodium thiosulfate, caprylhydroxamic acid, diiospropyl oxalate, disodium EDTA-copper, pentasodium pentetate, hydroxyethylethylenediaminetriacetic acid (HEDTA), oxalic acid, potassium citrate, sodium citrate, sodium oxalate, tris(2-Attorney Docket No.63230-732.601 hydroxyethyl)ammonium trihydrogen ethylenediaminetetraacetate (TEA-EDTA), or trisodium HEDTA, or a combination thereof. In some embodiments, the at least three chelating agents comprise pentasodium pentetate, trisodium MGDA, and sodium phytate. In some embodiments, the at least three chelating agents comprise tetrasodium GLDA, tetrasodium EDTA, or oxalic acid. In some embodiments, the at least three chelating agents comprise trisodium MGDA, sodium phytate, and sodium gluconate. In some embodiments, the at least three chelating agents comprise sodium phytate, sodium gluconate, and tetrasodium GLDA. In some embodiments, the at least three chelating agents comprise sodium gluconate, tetrasodium GLDA, and tetrasodium EDTA. In some embodiments, the at least three chelating agents comprise sodium gluconate, tetrasodium GLDA, and tetrasodium EDTA. In some embodiments, the at least three chelating agents comprise trisodium MGDA, tetrasodium GLDA, and tetrasodium EDTA. In some embodiments, the at least three chelating agents comprise trisodium MGDA, sodium gluconate, and tetrasodium EDTA. In some embodiments, the at least three chelating agents comprise trisodium MGDA, sodium gluconate, and tetrasodium GLDA. In some embodiments, the at least three chelating agents comprise trisodium MGDA, sodium gluconate, and potassium citrate. In some embodiments, the at least three chelating agents comprise sodium thiosulfate, sodium gluconate, and potassium citrate. In some embodiments, the at least three chelating agents comprise caprylhydroxamic acid, sodium gluconate, and potassium citrate. In some embodiments, the at least three chelating agents comprise sodium citrate, sodium gluconate, and potassium citrate. In some embodiments, the at least three chelating agents comprise trisodium HEDTA, sodium gluconate, and potassium citrate. In some embodiments, the at least three chelating agents comprise sodium thiosulfate, caprylhydroxamic acid, and diiospropyl oxalate. In some embodiments, the at least three chelating agents comprise trisodium dicarboxymethyl alaninate (trisodium MGDA), sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamate diacetate (tetrasodium GLDA), tetrasodium ethylenediaminetetraacetic acid (tetrasodium EDTA), trisodium EDTA, disodium EDTA, pentasodium pentetate, trisodium ethylenediamine succinate, sodium thiosulfate, caprylhydroxamic acid, diiospropyl oxalate, disodium EDTA-copper, hydroxyethylethylenediaminetriacetic acid (HEDTA), oxalic acid, potassium citrate, sodium citrate, sodium oxalate, tris(2- hydroxyethyl)ammonium trihydrogen ethylenediaminetetraacetate (TEA-EDTA), trisodium HEDTA, or a combination thereof. In some embodiments, the at least three chelating agents comprise trisodium MGDA, sodium phytate, sodium gluconate, tetrasodium GLDA, tetrasodium EDTA, or a combination thereof.

[0082] In some embodiments, the at least one chelating agent comprises at least four chelating agents. In some embodiments, the at least four chelating agents compriseAttorney Docket No.63230-732.601 ethylenediaminetetraacetic acid (EDTA) or salt thereof. In some instances, the at least four chelating agents comprise ethylenediaminetetraacetic acid (EDTA) or tetrasodium ethylenediaminetetraacetic acid (tetrasodium EDTA). In some embodiments, the at least four chelating agents comprise trisodium MGDA, sodium phytate, phytic acid, and sodium gluconate. In some embodiments, the at least four chelating agents comprise trisodium MGDA, sodium phytate, sodium gluconate, and tetrasodium GLDA. In some embodiments, the at least four chelating agents comprise trisodium MGDA, sodium gluconate, tetrasodium GLDA, and tetrasodium EDTA. In some embodiments, the at least four chelating agents comprise sodium phytate, sodium gluconate, tetrasodium GLDA, and tetrasodium EDTA. In some embodiments, the at least four chelating agents comprise sodium phytate, sodium phytate, tetrasodium GLDA, and tetrasodium EDTA. In some embodiments, the at least four chelating agents comprise sodium phytate, sodium phytate, tetrasodium GLDA, and tetrasodium EDTA. In some embodiments, the at least four chelating agents comprise tetrasodium EDTA, trisodium EDTA, disodium EDTA, and sodium gluconate. In some embodiments, the at least four chelating agents comprise pentasodium pentetate, tetrasodium GLDA, trisodium MGDA, and sodium phytate. In some embodiments, the at least four chelating agents comprise trisodium ethylenediamine succinate, sodium thiosulfate, and diisopropyl oxalate. In some embodiments, the at least four chelating agents comprise disodium EDTA-copper, oxalic acid, trisodium HEDTA, and sodium citrate. In some embodiments, the at least four chelating agents comprise oxalic acid, trisodium HEDTA, sodium citrate, and caprylhydroxamic acid. In some embodiments, the at least four chelating agents comprise oxalic acid, trisodium HEDTA, sodium citrate, and diisopropyl oxalate. In some embodiments, the at least four chelating agents comprise trisodium dicarboxymethyl alaninate (trisodium MGDA), sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamate diacetate (tetrasodium GLDA), tetrasodium ethylenediaminetetraacetic acid (tetrasodium EDTA), trisodium EDTA, disodium EDTA, pentasodium pentetate, trisodium ethylenediamine succinate, sodium thiosulfate, caprylhydroxamic acid, diiospropyl oxalate, disodium EDTA-copper, Hydroxyethylethylenediaminetriacetic acid (HEDTA), oxalic acid, potassium citrate, sodium citrate, sodium oxalate, tris(2- hydroxyethyl)ammonium trihydrogen ethylenediaminetetraacetate (TEA-EDTA), trisodium HEDTA, or a combination thereof. In some embodiments, the at least four chelating agents comprise trisodium MGDA, sodium phytate, sodium gluconate, tetrasodium GLDA, tetrasodium EDTA, or a combination thereof.

[0083] In some embodiments, at least one of the at least one chelating agent comprises ethylenediaminetetraacetic acid (EDTA) or salt thereof. In some instances, at least one of the at least one chelating agent comprises ethylenediaminetetraacetic acid (EDTA) or tetrasodiumAttorney Docket No.63230-732.601 ethylenediaminetetraacetic acid (tetrasodium EDTA). In some instances, at least one of the at least one chelating agent comprises tetrasodium EDTA.

[0084] In some instances, the at least one chelating agent comprises trisodium dicarboxymethyl alaninate (trisodium MGDA), sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamate diacetate (tetrasodium GLDA), pentasodium pentetate, trisodium ethylenediamine succinate, sodium thiosulfate, caprylhydroxamic acid, diisopropyl oxalate, oxalic acid, potassium citrate, sodium citrate, or sodium oxalate, or a combination thereof. In some instances, at least one chelating agent comprises trisodium MGDA, sodium phytate, sodium gluconate, tetrasodium GLDA, diisopropyl oxalate, oxalic acid, potassium citrate, or a combination thereof.

[0085] In some embodiments, the chelator composition is substantially free of ethylenediaminetetraacetic acid (EDTA).

[0086] In some embodiments, the at least one chelating agent binds to metal ions in the hair or water. In some embodiments, the at least one chelating agent binds to a metal ion in the hair that has been exposed to hard water.

[0087] In some embodiments, the at least one chelating agent is chosen based on the ability of the at least one chelating agent to complex with a metal. In some embodiments, the at least one chelating agent is chosen based on the ability of the at least one chelating agent to complex with a primary metal, a secondary metal, or a combination thereof. In some embodiments, the at least one chelating agent is selected based on the ability to complex with a primary metal. In some embodiments, the at least one chelating agent complexes with Ca, Mg, or a combination thereof. In some embodiments, the at least one chelating agent is selected based on the ability to complex with a secondary metal. In some embodiments, the at least one chelating agent complexes with Cu, Fe, Cr, Ni, Al, Pb, Zn, Cd, Hg, As, Ba, Co, Mn, Sn, W, Sb, Be, B, Bi, Cs, Li, Mo, Se, Sr, Tl, Ti, V, Sc, Ga, Y, Nb, Tc, Ru, Rh, Pd, In, Te, Re, Os, Ir, or a combination thereof. In some embodiments, the at least one chelating agent complexes with Ca, Mg, Cu, Fe, Cr, Ni, Al, Pb, Zn, Cd, Hg, As, Ba, Co, Mn, Sn, W, Sb, Be, B, Bi, Cs, Li, Mo, Se, Sr, Tl, Ti, V, Sc, Ga, Y, Nb, Tc, Ru, Rh, Pd, In, Te, Re, Os, Ir, or a combination thereof. In some embodiments, the at least one chelating agent complexes with Ca, Mg, Cu, Fe, Cr, Ni, Al, Pb, Zn, Cd, Hg, As, Ba, Co, Mn, Sn, W, Sb, Be, B, Bi, Cs, Li, Mo, Se, Sr, Tl, Ti, V, Sc, Ga, Y, Nb, Tc, Ru, Rh, Pd, In, Te, Re, Os, Ir, or a combination thereof. In some embodiments, the at least one chelating agent complexes with Ca, Mg, Cu, Cr, Fe, Al, Zn, Ni, Cd, Pb, Hg, or a combination thereof. In some embodiments, the at least one chelating agent complexes with Ca, Mg, Cu, Cr, Fe, Al, Zn, Ni, Cd, or Pb, or a combination thereof. In some embodiments, the at least one chelating agent complexes with Ca, Mg, Cu, Fe, Mn, Zn, or a combination thereof. In some embodiments, the at least one chelating agent complexes with Ca,Attorney Docket No.63230-732.601 Mg, Cu, Fe, Mn, or a combination thereof. In some embodiments, the at least one chelating agent complexes with Ca, Mg, Fe, Zn, or a combination thereof. In some embodiments, the at least one chelating agent complexes with Ca, Fe, Co, Zn, or a combination thereof. In some embodiments, the at least one chelating agent complexes with Na, Cu, Li, or a combination thereof.

[0088] In some embodiments, the at least one chelating agent comprises trisodium MGDA, which complexes with polyvalent metal ions. In some instances, trisodium MGDA complexes with Ca2+, Cu2+, Fe3+, Mg2+, Mn2+, or a combination thereof. In some embodiments, the at least one chelating agent comprises sodium phytate. In some instances, sodium phytate complexes with Ca2+, Mg2+, Fe3+, Zn2+, or a combination thereof. In some embodiments, the at least one chelating agent comprises sodium gluconate. In some instances, sodium gluconate coordinates or chelates to a monovalent ion. In some instances, the monovalent ion may be Na+, Cu+, or a combination thereof. In some embodiments, the at least one chelating agent comprises tetrasodium glutamate diacetate. In some instances, tetrasodium glutamate diacetate complexes with Ca2+, Cu2+, Fe3+, Mg2+, Mn2+, Zn2+, or a combination thereof. In some embodiments, the at least one chelating agent comprises tetrasodium EDTA. In some instances, tetrasodium EDTA complexes with Fe3+, Co2+, Zn2+, Ca2+, or a combination thereof. In some embodiments, the at least one chelating agent comprises sodium citrate or potassium citrate. In some instances, potassium citrate or sodium citrate complexes with Fe2+, Fe3+, Mn2+, Co2+, Al3+, or a combination thereof. In some embodiments, the at least one chelating agent comprises pentasodium pentetate. In some instances, pentasodium pentetate binds to Tc4+, Zn2+, Mg2+, Mn2+, or a combination thereof.

[0089] In some embodiments, the at least one chelating agent may carry a net negative charge. In some embodiments, the at least one chelating agent may carry a total net negative charge corresponding to a sum of a net negative charge of each of the at least one chelating agent. In some embodiments, the at least one chelating agent may carry a net negative charge over a pH of about pH 6 to about pH 9, about pH 7 to about pH 8, about pH 7 to about pH 9, or of about pH 6 to about pH 8. In some embodiments, the net negative charge of each of the at least one chelating agent over the pH range is -1, -2, -3, -4, or -5.

[0090] In some embodiments, the total concentration (%w / w by total weight) of the chelator composition comprising at least one chelating agent is about 0.005% to about 25%, about 0.01% to about 25%, about 0.025% to about 25%, about 0.1% to about 25%, about 0.5% to about 25%, about 1% to about 25%, about 2% to about 25%, about 3% to about 25%, about 4% to about 25%, about 5% to about 25%, about 6% to about 25%, about 7% to about 25%, about 8% to about 25%, about 9% to about 25%, about 10% to about 25%, about 11% to about 25%, about 12% to about 25%, about 13% to about 25%, about 14% to about 25%, about 15% to about 25%, about 16% to aboutAttorney Docket No.63230-732.601 25%, about 17% to about 25%, about 18% to about 25%, about 19% to about 25%, about 20% to about 25%, about 21% to about 25%, about 22% to about 25%, about 23% to about 25%, or about 24% to about 25%. In some embodiments, the total concentration (%w / w by total weight) of the chelator composition comprising at least one chelating agent is about 0.005% to about 15%, about 0.01% to about 15%, about 0.05% to about 15%, about 0.1% to about 15%, about 0.5% to about 15%, about 1% to about 15%, about 2% to about 15%, about 3% to about 15%, about 4% to about 15%, about 5% to about 15%, about 6% to about 15%, about 7% to about 15%, about 8% to about 15%, or about 9% to about 15%. In some embodiments, the concentration (%w / w) of the chelator composition is about 0.005%, about 0.01%, about 0.025%, about 0.05%, about 0.1%, about 0.5%, about 1%, about 2%, about 3%, about 4%, about 5%, about 6%, about 7%, about 8%, about 9%, about 10%, about 11%, about 12%, about 13%, about 14%, about 15%, about 16%, about 17%, about 18%, about 19%, about 20%, about 21%, about 22%, about 23%, about 24%, about 25%, or any values therebetween. In some embodiments, the concentration (%w / w) of the chelator composition is at least about 0.005%, at least about 0.01%, at least about 0.025%, at least about 0.05%, at least about 0.1%, at least about 0.5%, at least about 1%, at least about 2%, at least about 3%, at least about 4%, at least about 5%, at least about 6%, at least about 7%, at least about 8%, at least about 9%, at least about 10%, at least about 11%, at least about 12%, at least about 13%, at least about 14%, at least about 15%, at least about 16%, at least about 17%, at least about 18%, at least about 19%, at least about 20%, at least about 21%, at least about 22%, at least about 23%, at least about 24%, at least about 25%, or any values therebetween. In some embodiments, the concentration (%w / w) of the chelator composition is at most about 0.005%, at most about 0.01%, at most about 0.025%, at most about 0.05%, at most about 0.1%, at most about 0.5%, at most about 1%, at most about 2%, at most about 3%, at most about 4%, at most about 5%, at most about 6%, at most about 7%, at most about 8%, at most about 9%, at most about 10%, at most about 11%, at most about 12%, at most about 13%, at most about 14%, at most about 15%, at most about 16%, at most about 17%, at most about 18%, at most about 19%, at most about 20%, at most about 21%, at most about 22%, at most about 23%, at most about 24%, at most about 25%, or any values therebetween. In some embodiments, the total concentration (%w / w) of the chelator composition is about 0.005% to about 15%, about 0.01% to about 15%, about 0.2% to about 14%, about 0.4% to about 13%, about 0.6% to about 12%, about 0.8% to about 11%, about 1% to about 10%, about 1.2% to about 9%, about 1.4% to about 8%, about 1.6% to about 7%, about 1.8% and about 6%, about 2% to about 5%, or about 3% to about 4%.

[0091] In some embodiments, the concentration (%w / w) of each of the at least one chelating agent in the composition is about 0.005%, about 0.01%, about 0.05%, about 0.1%, about 0.2%, aboutAttorney Docket No.63230-732.601 0.4%, about 0.6%, about 0.8%, about 1%, about 1.2%, about 1.4%, about 1.6%, about 1.8%, about 2%, about 3%, about 4%, about 5%, about 6%, about 7%, about 8%, about 9%, about 10%, about 11%, about 12%, about 13%, about 14%, about 15%, or any values therebetween. In some embodiments, the concentration (%w / w) of each of the at least one chelating agent in the composition is at least about 0.005%, at least about 0.01%, at least about 0.05%, at least about 0.1%, at least about 0.2%, at least about 0.4%, at least about 0.6%, at least about 0.8%, at least about 1%, at least about 1.2%, at least about 1.4%, at least about 1.6%, at least about 1.8%, at least about 2%, at least about 3%, at least about 4%, at least about 5%, at least about 6%, at least about 7%, at least about 8%, at least about 9%, at least about 10%, at least about 11%, at least about 12%, at least about 13%, at least about 14%, at least about 15%, or any values therebetween. In some embodiments, the concentration (%w / w) of each of the at least one chelating agent in the composition is at most about 0.005%, at most about 0.01%, at most about 0.05%, at most about 0.1%, at most about 0.2%, at most about 0.4%, at most about 0.6%, at most about 0.8%, at most about 1%, at most about 1.2%, at most about 1.4%, at most about 1.6%, at most about 1.8%, at most about 2%, at most about 3%, at most about 4%, at most about 5%, at most about 6%, at most about 7%, at most about 8%, at most about 9%, at most about 10%, at most about 11%, at most about 12%, at most about 13%, at most about 14%, at most about 15%, or any values therebetween. In some embodiments, the total concentration (%w / w) of the at least one chelating agent in the composition is about 0.005% to about 15%, about 0.01% to about 15%, about 0.05% to about 15%, about 0.1% to about 15%, about 0.2% to about 14%, about 0.4% to about 13%, about 0.6% to about 12%, about 0.8% to about 11%, about 1% to about 10%, about 1.2% to about 9%, about 1.4% to about 8%, about 1.6% to about 7%, about 1.8% and about 6%, about 2% to about 5%, or about 3% to about 4%.

[0092] In some embodiments, when two or more chelating agents are present, the concentration of each chelating agent may be the same. In some embodiments, when two or more chelating agents are present, the concentration of each chelating agent may be different.

[0093] In some embodiments, the at least one chelating agent comprises trisodium MGDA, wherein the trisodium MGDA is present in the composition at about 0.005% to about 5% by weight, about 0.1% to about 2% by weight, about 0.5% to about 2% by weight, about 0.6% to about 2% by weight, about 0.7% to about 2% by weight, about 0.8% to about 2% by weight, about 0.9% to about 2% by weight, about 1% to about 2% by weight, about 1% to about 2% by weight, about 1.1% to about 2% by weight, about 1.2% to about 2% by weight, about 1.3% to about 2% by weight, about 1.4% to about 2% by weight, about 1.5% to about 2% by weight, 0.5% to about 1% by weight, about 0.6% to about 1% by weight, about 0.7% to about 1% by weight, about 0.8% toAttorney Docket No.63230-732.601 about 1% by weight, or about 0.9% to about 1% by weight. In some instances, the trisodium MGDA is present in the composition at about 0.005%, about 0.05%, about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.8%, about 1.9%, about 2%, or about 5% by weight of the composition. In some instances, the trisodium MGDA is present in the composition at least about 0.005%, at least about 0.05%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.1%, at least about 1.2%, at least about 1.3%, at least about 1.4%, at least about 1.5%, at least about 1.6%, at least about 1.8%, at least about 1.9%, at least about 2%, or at least about 5% by weight of the composition. In some instances, the trisodium MGDA is present in the composition at most about 0.005%, at most about 0.05%, at most about 0.1%, at most about 0.2%, at most about 0.3%, at most about 0.4%, at most about 0.5%, at most about 0.6%, at most about 0.7%, at most about 0.8%, at most about 0.9%, at most about 1%, at most about 1.1%, at most about 1.2%, at most about 1.3%, at most about 1.4%, at most about 1.5%, at most about 1.6%, at most about 1.8%, at most about 1.9%, at most about 2%, or at most about 5% by weight of the composition.

[0094] In some embodiments, the at least one chelating agent comprises sodium phytate, wherein the sodium phytate is present in the composition at about 0.005% to about 5% by weight, about 0.1% to about 2% by weight, about 0.5% to about 2% by weight, about 0.6% to about 2% by weight, about 0.7% to about 2% by weight, about 0.8% to about 2% by weight, about 0.9% to about 2% by weight, about 1% to about 2% by weight, about 1% to about 2% by weight, about 1.1% to about 2% by weight, about 1.2% to about 2% by weight, about 1.3% to about 2% by weight, about 1.4% to about 2% by weight, about 1.5% to about 2% by weight, 0.5% to about 1% by weight, about 0.6% to about 1% by weight, about 0.7% to about 1% by weight, about 0.8% to about 1% by weight, or about 0.9% to about 1% by weight. In some instances, the sodium phytate is present in the composition at about 0.005%, about 0.05%, about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.8%, about 1.9%, about 2%, or about 5% by weight of the composition. In some instances, the sodium phytate is present in the composition at least about 0.005%, at least about 0.05%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.1%, at least about 1.2%, at least about 1.3%, at least about 1.4%, at least about 1.5%, at least about 1.6%, at least about 1.8%, at least about 1.9%, at least about 2%, or at least about 5% by weight of the composition. In someAttorney Docket No.63230-732.601 instances, the sodium phytate is present in the composition at most about 0.005%, at most about 0.05%, at most about 0.1%, at most about 0.2%, at most about 0.3%, at most about 0.4%, at most about 0.5%, at most about 0.6%, at most about 0.7%, at most about 0.8%, at most about 0.9%, at most about 1%, at most about 1.1%, at most about 1.2%, at most about 1.3%, at most about 1.4%, at most about 1.5%, at most about 1.6%, at most about 1.8%, at most about 1.9%, at most about 2%, or at most about 5% by weight of the composition.

[0095] In some embodiments, the at least one chelating agent comprises sodium gluconate, wherein the sodium gluconate is present in the composition at about 0.005% to about 5% by weight, about 0.1% to about 2% by weight, about 0.5% to about 2% by weight, about 0.6% to about 2% by weight, about 0.7% to about 2% by weight, about 0.8% to about 2% by weight, about 0.9% to about 2% by weight, about 1% to about 2% by weight, about 1% to about 2% by weight, about 1.1% to about 2% by weight, about 1.2% to about 2% by weight, about 1.3% to about 2% by weight, about 1.4% to about 2% by weight, about 1.5% to about 2% by weight, 0.5% to about 1% by weight, about 0.6% to about 1% by weight, about 0.7% to about 1% by weight, about 0.8% to about 1% by weight, or about 0.9% to about 1% by weight. In some instances, the sodium gluconate is present in the composition at about 0.005%, about 0.05%, about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.8%, about 1.9%, about 2%, or about 5% by weight of the composition. In some instances, the sodium gluconate is present in the composition at least about 0.005%, at least about 0.05%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.1%, at least about 1.2%, at least about 1.3%, at least about 1.4%, at least about 1.5%, at least about 1.6%, at least about 1.8%, at least about 1.9%, at least about 2%, or at least about 5% by weight of the composition. In some instances, the sodium gluconate is present in the composition at most about 0.005%, at most about 0.05%, at most about 0.1%, at most about 0.2%, at most about 0.3%, at most about 0.4%, at most about 0.5%, at most about 0.6%, at most about 0.7%, at most about 0.8%, at most about 0.9%, at most about 1%, at most about 1.1%, at most about 1.2%, at most about 1.3%, at most about 1.4%, at most about 1.5%, at most about 1.6%, at most about 1.8%, at most about 1.9%, at most about 2%, or at most about 5% by weight of the composition.

[0096] In some embodiments, the at least one chelating agent comprises tetrasodium glutamate diacetate, wherein the tetrasodium glutamate diacetate is present in the composition at about 0.005% to about 5% by weight, about 0.1% to about 2% by weight, about 0.5% to about 2% by weight, about 0.6% to about 2% by weight, about 0.7% to about 2% by weight, about 0.8% to aboutAttorney Docket No.63230-732.601 2% by weight, about 0.9% to about 2% by weight, about 1% to about 2% by weight, about 1% to about 2% by weight, about 1.1% to about 2% by weight, about 1.2% to about 2% by weight, about 1.3% to about 2% by weight, about 1.4% to about 2% by weight, about 1.5% to about 2% by weight, 0.5% to about 1% by weight, about 0.6% to about 1% by weight, about 0.7% to about 1% by weight, about 0.8% to about 1% by weight, or about 0.9% to about 1% by weight. In some instances, the tetrasodium glutamate diacetate is present in the composition at about 0.005%, about 0.05%, about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.8%, about 1.9%, about 2%, or about 5% by weight of the composition. In some instances, the tetrasodium glutamate diacetate is present in the composition at least about 0.005%, at least about 0.05%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.1%, at least about 1.2%, at least about 1.3%, at least about 1.4%, at least about 1.5%, at least about 1.6%, at least about 1.8%, at least about 1.9%, at least about 2%, or at least about 5% by weight of the composition. In some instances, the tetrasodium glutamate diacetate is present in the composition at most about 0.005%, at most about 0.05%, at most about 0.1%, at most about 0.2%, at most about 0.3%, at most about 0.4%, at most about 0.5%, at most about 0.6%, at most about 0.7%, at most about 0.8%, at most about 0.9%, at most about 1%, at most about 1.1%, at most about 1.2%, at most about 1.3%, at most about 1.4%, at most about 1.5%, at most about 1.6%, at most about 1.8%, at most about 1.9%, at most about 2%, or at most about 5% by weight of the composition.

[0097] In some embodiments, the at least one chelating agent comprises tetrasodium EDTA, wherein the tetrasodium EDTA is present in the composition at about 0.005% to about 5% by weight, about 0.1% to about 2% by weight, about 0.5% to about 2% by weight, about 0.6% to about 2% by weight, about 0.7% to about 2% by weight, about 0.8% to about 2% by weight, about 0.9% to about 2% by weight, about 1% to about 2% by weight, about 1% to about 2% by weight, about 1.1% to about 2% by weight, about 1.2% to about 2% by weight, about 1.3% to about 2% by weight, about 1.4% to about 2% by weight, about 1.5% to about 2% by weight, 0.5% to about 1% by weight, about 0.6% to about 1% by weight, about 0.7% to about 1% by weight, about 0.8% to about 1% by weight, or about 0.9% to about 1% by weight. In some instances, the tetrasodium EDTA is present in the composition at about 0.005%, about 0.05%, about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.8%, about 1.9%, about 2%, or about 5% by weight of the composition. In some instances, the tetrasodium EDTA isAttorney Docket No.63230-732.601 present in the composition at least about 0.005%, at least about 0.05%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.1%, at least about 1.2%, at least about 1.3%, at least about 1.4%, at least about 1.5%, at least about 1.6%, at least about 1.8%, at least about 1.9%, at least about 2%, or at least about 5% by weight of the composition. In some instances, the tetrasodium EDTA is present in the composition at most about 0.005%, at most about 0.05%, at most about 0.1%, at most about 0.2%, at most about 0.3%, at most about 0.4%, at most about 0.5%, at most about 0.6%, at most about 0.7%, at most about 0.8%, at most about 0.9%, at most about 1%, at most about 1.1%, at most about 1.2%, at most about 1.3%, at most about 1.4%, at most about 1.5%, at most about 1.6%, at most about 1.8%, at most about 1.9%, at most about 2%, or at most about 5% by weight of the composition.

[0098] In some embodiments, the at least one chelating agent and the at least one antioxidant work together to address the negative effects associated with metal build up in the hair. Foaming Agent

[0099] In some embodiments, the composition described herein is formulated as a foam. In some instances, the composition described herein comprises a foaming gent. In some instances, the foaming agent comprises a surfactant, a copolymer, or a combination thereof. Surfactant

[0100] In some instances, the composition for removing metals from hair further comprises at least one surfactant. In some instances, as described herein, a surfactant refers to an agent that reduces surface tension and increases spreading or wetting properties of composition. In some instances, a surfactant refers to an agent or a molecule that has hydrophobic and hydrophilic regions.

[0101] In some embodiments, the surfactant is an anionic surfactant, an amphoteric surfactant, a nonionic surfactant, or a combination thereof. In some embodiments, the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium xylenesulfonate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium 2-sulfolaurate, sodium myreth sulfate, sodium xylenesulfonate, sodium C14-16 olefin sulfonate, sodium C14-16 alpha olefin sulfonate, disodium lauryl sulfosuccinate, sodium methyl cocoyl taurate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, lauroyl sarcosine, cocoyl sarcosine, myristoyl sarcosine, oleoyl sarcosine, myristoyl / stearoyl sarcosine, sodium lauroyl glutamate, sodium cocoyl glutamate, disodium cocoyl glutamate, cocoyl glutamic acid, lauroyl glutamic acid, potassium cocoyl glutamate, potassium lauroyl glutamate, potassium myristoyl glutamate, sodium myristoyl glutamate, sodium stearoylAttorney Docket No.63230-732.601 glutamate, disodium stearoyl glutamate, sodium palmitoyl glutamate, sodium lauroyl lactylate, sodium astrocaryum murumuruate, sodium laurylglucoside hydroxypropylsulfonate, disodium laurylglucoside hydroxypropyl citrate, sodium hydroxypropylsulfonate laurylglucoside crosspolymer, dioctyl sodium sulfosuccinate, or a combination thereof.

[0102] In some embodiments, the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauryl betaine, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium dilauramidoglutamide lysine, sodium cocoamphopropionate, lauroamphoacetate, or a combination thereof.

[0103] In some embodiments, the nonionic surfactant is decyl glucoside, lauryl glucoside, coco- glucoside, cocoyl methyl glucamide, capryloyl / caproyl methyl glucamide, lauroyl / myristoyl methyl glucamide, cocamidopropylamine oxide, decylamine oxide, or a combination thereof.

[0104] In some embodiments, the at least one surfactant is a solubilizer. In some instances, as described herein, a solubilizer refers to an agent that are water soluble with little oil solubility. In some instances, a solubilizer can be utilized to better dissolve a hydrophobic agent, such as oil or other insoluble liquid, in water or hydrophilic solution. In some embodiments, the solubilizer comprises polysorbate 20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, or sodium surfactin, or a combination thereof.

[0105] In some embodiments, the at least one surfactant comprises a liquid, a saccharide, or a combination thereof. In some embodiments, the lipid comprises a rhamnolipid, a glycolipid (e.g., a sophorolipid), lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium lauroyl sarcosinate, sodium lauroyl isethionate, sodium cocoyl isethionate, lauroyl sarcosine, sodium lauroyl glutamate, sodium methyl cocoyl taurate, disodium cocoamphodiacetate, sodium C14-16olefin sulfonate, sodium C14-16 alpha olefin sulfonate, cocamidopropyl betaine (CAPB), betaine, lauryl betaine, lauramidopropyl hydroxysultaine, cocamidopropyl hydroxysultaine, or a combination thereof. In some embodiments, the saccharide comprises decyl glucoside, lauryl glucoside, coco-glucoside, maltooligosyl glucoside, hydrogenated starch hydrolysate, or a combination thereof.

[0106] In some instances, the at least one surfactant is a natural surfactant. In some embodiments, the at least one surfactant comprises a cleanser. In some instances, as used herein, a cleanser refers to an agent that helps removes impurities, such as dirt or oils, from hair. In some instances, the cleanser is added into the composition for removing metals from hair for gentle cleansing to helpAttorney Docket No.63230-732.601 washout or rinse the chelator composition. In some embodiments, the cleanser comprises Sapindus mukorossi (soapnut) peel extract, potassium cocoyl hydrolyzed oat protein, Starmella bombicola / brassica oil ferment, sophorolipids, canola sophorolipids, rhamnolipids, glycolipids, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium lauroyl sarcosinate, sodium lauroyl isethionate, sodium cocoyl isethionate, lauroyl sarcosine, sodium lauroyl glutamate, sodium methyl cocoyl taurate, disodium cocoamphodiacetate, sodium C14-16olefin sulfonate, sodium C14-16alpha olefin sulfonate, benzethonium chloride, cocamidopropylamine oxide, decylamine oxide, decyl glucoside, lauryl glucoside, coco-glucoside, cocamidopropyl betaine, betaine, lauryl betaine, lauramidopropyl hydroxysultaine, cocamidopropyl hydroxysultaine, maltooligosyl glucoside, hydrogenated starch hydrolysate, or a combination thereof.

[0107] In some embodiments, the composition comprises biosurfactant from soapnut. In some embodiments, the composition comprises Sapindus mukaorossi (soapnut) extract. The soapnut extract is a source of saponins that are biodegradable, making them natural surfactant molecules with high environmental compatibility and lower toxicity. In some instances, the soapnut extract is effective in hard water due to its chelating ability and good foaming ability.

[0108] In some instances, the surfactant comprises benzethonium chloride, betaine, cocamide diethanolamine, cocamidopropyl betaine, cocamidopropyl betaine (CAPB), cocamidopropyl hydroxysultaine, cocamidopropylamine oxide, coco-glucoside, decyl glucoside, decylamine oxide, dimyristoyl phosphatidylcholine, dipalmitoyl phosphatidylcholine, disodium cocoamphodiacetate, distearoyl phosphatidylcholine, hydrogenated starch hydrolysate, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauroyl sarcosine, lauryl betaine, lauryl glucoside, lauryl hydroxysultaine, maltooligosyl glucoside, potassium cocoyl hydrolyzed oat protein, sodium C14-16 alpha olefin sulfonate, sodium C14-16 olefin sulfonate, sodium cocoyl isethionate, sodium lauroyl glutamate, sodium lauroyl isethionate, sodium lauroyl sarcosinate, sodium methyl cocoyl taurate, sucrose glucoside, caprylyl / capryl glucoside, Starmella bombicola / brassica oil ferment, Sapindus mukorossi peel extract, sophorolipid, coconut extract, palm kernel extract, or a combination thereof. In some instances, the surfactant comprises a sophorolipid, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium lauroyl sarcosinate, sodium lauroyl isethionate, sodium cocoyl isethionate, lauroyl sarcosine, sodium lauroyl glutamate, sodium methyl cocoyl taurate, disodium cocoamphodiacetate, sodium C14-16 olefin sulfonate, sodium C14-16 alpha olefin sulfonate, cocamide diethanolamine, cocamidopropyl betaine (CAPB), cocobetaine, betaine, lauryl betaine, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, cocamidopropyl hydroxysultaine, dipalmitoyl phosphatidylcholine, dimyristoyl phosphatidylcholine, distearoyl phosphatidylcholine, or a combination thereof. In some instances, the surfactant comprises aAttorney Docket No.63230-732.601 saccharide comprising decyl glucoside, lauryl glucoside, coco-glucoside, maltooligosyl glucoside, hydrogenated starch hydrolysate, or a combination thereof. In some instances, the surfactant is selected from the group of Sapindus mukorossi peel extract, potassium cocoyl hydrolyzed oat protein, Starmella bombicola / brassica oil ferment, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium lauroyl sarcosinate, sodium lauroyl isethionate, sodium cocoyl isethionate, lauroyl sarcosine, sodium lauroyl glutamate, sodium methyl cocoyl taurate, disodium cocoamphodiacetate, sodium C14-16 olefin sulfonate, sodium C14-16 alpha olefin sulfonate, benzethonium chloride, cocamidopropylamine oxide, decylamine oxide, decyl glucoside, lauryl glucoside, coco-glucoside, cocamidopropyl betaine, betaine, lauryl betaine, lauramidopropyl hydroxysultaine, cocamidopropyl hydroxysultaine, maltooligosyl glucoside, hydrogenated starch hydrolysate, or a combination thereof.

[0109] In some instances, the surfactant comprises polysorbate 20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, or a combination thereof.

[0110] In some instances, the composition comprises a first surfactant and a second surfactant. In some instances, the first surfactant comprises Starmella bombicola / brassica oil ferment, Sapindus mukorossi peel extract, sophorolipid, coconut extract, or palm kernel extract, or a combination thereof. In some instances, the second surfactant comprises benzethonium chloride, betaine, cocamide diethanolamine, cocamidopropyl betaine, cocamidopropyl betaine (CAPB), cocamidopropyl hydroxysultaine, cocamidopropylamine oxide, coco-glucoside, decyl glucoside, decylamine oxide, dimyristoyl phosphatidylcholine, dipalmitoyl phosphatidylcholine, disodium cocoamphodiacetate, distearoyl phosphatidylcholine, hydrogenated starch hydrolysate, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauroyl sarcosine, lauryl betaine, lauryl glucoside, lauryl hydroxysultaine, maltooligosyl glucoside, potassium cocoyl hydrolyzed oat protein, sodium C14-16 alpha olefin sulfonate, sodium C14-16 olefin sulfonate, sodium cocoyl isethionate, sodium lauroyl glutamate, sodium lauroyl isethionate, sodium lauroyl sarcosinate, sodium methyl cocoyl taurate, sucrose glucoside, or caprylyl / capryl glucoside, or a combination thereof.

[0111] In some embodiments, the total concentration (%w / w) of the surfactant in the composition for removing metals from hair is about 0.05% to about 90%, about 0.1% to about 90%, about 0.5% to about 90%, about 1% to about 90%, about 5% to about 90%, about 10% to about 90%, about 15% to about 90%, about 20% to about 90%, or about 25% to about 90%. In some embodiments, the total concentration (%w / w) of the surfactant in the composition for removing metals from hair is about 0.05% to about 30%, about 0.1% to about 30%, about 0.5% to about 30%, about 1% toAttorney Docket No.63230-732.601 about 30%, about 5% to about 30%, about 10% to about 30%, about 15% to about 30%, about 20% to about 30%, or about 25% to about 30%. In some embodiments, the total concentration (%w / w) of the surfactant in the composition is about 0.05%, about 0.1%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, about 12%, about 14%, about 16%, about 18%, about 20%, about 22%, about 24%, about 26%, about 28%, about 30%, or any values therebetween. In some embodiments, the total concentration (%w / w) of the surfactant in the composition is at least about 0.05%, at least about 0.1%, at least about 0.5%, at least about 1%, at least about 1.5%, at least about 2%, at least about 2.5%, at least about 3%, at least about 3.5%, at least about 4%, at least about 4.5%, at least about 5%, at least about 5.5%, at least about 6%, at least about 6.5%, at least about 7%, at least about 7.5%, at least about 8%, at least about 8.5%, at least about 9%, at least about 9.5%, at least about 10%, at least about 12%, at least about 14%, at least about 16%, at least about 18%, at least about 20%, at least about 22%, at least about 24%, at least about 26%, at least about 28%, or at least about 30%. In some embodiments, the total concentration (%w / w) of the surfactant in the composition is at most about 0.05%, at most about 0.1%, at most about 0.5%, at most about 1%, at most about 1.5%, at most about 2%, at most about 2.5%, at most about 3%, at most about 3.5%, at most about 4%, at most about 4.5%, at most about 5%, at most about 5.5%, at most about 6%, at most about 6.5%, at most about 7%, at most about 7.5%, at most about 8%, at most about 8.5%, at most about 9%, at most about 9.5%, at most about 10%, at most about 12%, at most about 14%, at most about 16%, at most about 18%, at most about 20%, at most about 22%, at most about 24%, at most about 26%, at most about 28%, or at most about 30%.

[0112] In some instances, the total concentration of the surfactant in the composition is about 0.1% (w / w) to about 90% (w / w), about 0.1% (w / w) to about 80% (w / w), about 0.1% (w / w) to about 70% (w / w), about 0.1% (w / w) to about 60% (w / w), about 0.1% (w / w) to about 50% (w / w), about 0.1% (w / w) to about 40% (w / w), or about 0.1% (w / w) to about 30% (w / w) of a total weight of the composition.

[0113] In some embodiments, the total concentration of the surfactant in the foam is about 1% (w / w) to about 30% (w / w) of the total weight of the composition.

[0114] In some embodiments, the total concentration of the surfactant in the composition is about 5% (w / w) to about 20% (w / w) of the total weight of the composition.

[0115] In some embodiments, the concentration (%w / w) of each of the at least one surfactant in the composition is about 0.05%, about 0.1%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%,Attorney Docket No.63230-732.601 about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, about 12%, about 14%, about 16%, about 18%, about 20%, about 22%, about 24%, about 26%, about 28%, about 30%, or any values therebetween. In some embodiments, the concentration (%w / w) of each of the at least one surfactant in the composition is at least about 0.05%, at least about 0.1%, at least about 0.5%, at least about 1%, at least about 1.5%, at least about 2%, at least about 2.5%, at least about 3%, at least about 3.5%, at least about 4%, at least about 4.5%, at least about 5%, at least about 5.5%, at least about 6%, at least about 6.5%, at least about 7%, at least about 7.5%, at least about 8%, at least about 8.5%, at least about 9%, at least about 9.5%, at least about 10%, at least about 12%, at least about 14%, at least about 16%, at least about 18%, at least about 20%, at least about 22%, at least about 24%, at least about 26%, at least about 28%, or at least about 30%. In some embodiments, the concentration (%w / w) of each of the at least one surfactant in the composition is at most about 0.05%, at most about 0.1%, at most about 0.5%, at most about 1%, at most about 1.5%, at most about 2%, at most about 2.5%, at most about 3%, at most about 3.5%, at most about 4%, at most about 4.5%, at most about 5%, at most about 5.5%, at most about 6%, at most about 6.5%, at most about 7%, at most about 7.5%, at most about 8%, at most about 8.5%, at most about 9%, at most about 9.5%, at most about 10%, at most about 12%, at most about 14%, at most about 16%, at most about 18%, at most about 20%, at most about 22%, at most about 24%, at most about 26%, at most about 28%, or at most about 30%. In some embodiments, the concentration (%w / w) of each of the at least one surfactant in the composition is about 0.05% to about 30%, about 0.1% to about 28%, about 0.5% to about 26%, about 1% to about 24%, about 1.5% to about 22%, about 2% to about 20%, about 2.5% to about 18%, about 3% to about 16%, about 3.5% to about 14%, about 4% to about 12%, about 4.5% to about 10%, about 5% to about 9.5%, about 5.5% to about 9%, about 6% to about 8.5%, about 6.5% to about 8%, or about 7% to about 7.5%.

[0116] In some embodiments, the composition comprises polysorbate 20 at about 0% to about 5% by weight, about 0.1% to about 5% by weight, about 0.5% to about 5% by weight, about 1% to about 5% by weight, about 2% to about 5% by weight, about 1% to about 2% by weight. In some instances, the polysorbate 20 is present in the composition at about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.8%, about 1.9%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, or about 5% by weight of the composition. In some embodiments, the concentration (%w / w) of polysorbate 20 in the composition is about 0.05%, about 0.1%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, about 12%, aboutAttorney Docket No.63230-732.601 14%, about 16%, about 18%, about 20%, about 22%, about 24%, about 26%, about 28%, about 30%, or any values therebetween. In some embodiments, the concentration (%w / w) of polysorbate 20 in the composition is at least about 0.05%, at least about 0.1%, at least about 0.5%, at least about 1%, at least about 1.5%, at least about 2%, at least about 2.5%, at least about 3%, at least about 3.5%, at least about 4%, at least about 4.5%, at least about 5%, at least about 5.5%, at least about 6%, at least about 6.5%, at least about 7%, at least about 7.5%, at least about 8%, at least about 8.5%, at least about 9%, at least about 9.5%, at least about 10%, at least about 12%, at least about 14%, at least about 16%, at least about 18%, at least about 20%, at least about 22%, at least about 24%, at least about 26%, at least about 28%, or at least about 30%. In some embodiments, the concentration (%w / w) of polysorbate 20 in the composition is at most about 0.05%, at most about 0.1%, at most about 0.5%, at most about 1%, at most about 1.5%, at most about 2%, at most about 2.5%, at most about 3%, at most about 3.5%, at most about 4%, at most about 4.5%, at most about 5%, at most about 5.5%, at most about 6%, at most about 6.5%, at most about 7%, at most about 7.5%, at most about 8%, at most about 8.5%, at most about 9%, at most about 9.5%, at most about 10%, at most about 12%, at most about 14%, at most about 16%, at most about 18%, at most about 20%, at most about 22%, at most about 24%, at most about 26%, at most about 28%, or at most about 30%.

[0117] In some embodiments, the composition comprises Sapindus mukorossi peel extract at about 0% to about 5% by weight, about 0.1% to about 5% by weight, about 0.5% to about 5% by weight, about 1% to about 5% by weight, about 2% to about 5% by weight, about 1% to about 2% by weight. In some instances, the Sapindus mukorossi peel extract is present in the composition at about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.8%, about 1.9%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, or about 5% by weight of the composition. In some embodiments, the concentration (%w / w) of Sapindus mukorossi peel extract in the composition is about 0.05%, about 0.1%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, about 12%, about 14%, about 16%, about 18%, about 20%, about 22%, about 24%, about 26%, about 28%, about 30%, or any values therebetween. In some embodiments, the concentration (%w / w) of Sapindus mukorossi peel extract in the composition is at least about 0.05%, at least about 0.1%, at least about 0.5%, at least about 1%, at least about 1.5%, at least about 2%, at least about 2.5%, at least about 3%, at least about 3.5%, at least about 4%, at least about 4.5%, at least about 5%, at least about 5.5%, at least about 6%, at least about 6.5%, at leastAttorney Docket No.63230-732.601 about 7%, at least about 7.5%, at least about 8%, at least about 8.5%, at least about 9%, at least about 9.5%, at least about 10%, at least about 12%, at least about 14%, at least about 16%, at least about 18%, at least about 20%, at least about 22%, at least about 24%, at least about 26%, at least about 28%, or at least about 30%. In some embodiments, the concentration (%w / w) of Sapindus mukorossi peel extract in the composition is at most about 0.05%, at most about 0.1%, at most about 0.5%, at most about 1%, at most about 1.5%, at most about 2%, at most about 2.5%, at most about 3%, at most about 3.5%, at most about 4%, at most about 4.5%, at most about 5%, at most about 5.5%, at most about 6%, at most about 6.5%, at most about 7%, at most about 7.5%, at most about 8%, at most about 8.5%, at most about 9%, at most about 9.5%, at most about 10%, at most about 12%, at most about 14%, at most about 16%, at most about 18%, at most about 20%, at most about 22%, at most about 24%, at most about 26%, at most about 28%, or at most about 30%.

[0118] In some instances, the anionic surfactant has a net negative charge at a pH of about 4 to about 9. In some instances, the anionic surfactant has a net negative charge at a pH of about 4 to about 8, about 4 to about 7, about 4 to about 6, about 4 to about 5, about 5 to about 9, about 5 to about 8, about 5 to about 7, about 5 to about 6, about 6 to about 9, about 6 to about 8, about 6 to about 7, about 7 to about 9, about 7 to about 8, orabout 8 to about 9.

[0119] In some instances, the cationic surfactant has a net positive charge at a pH of about 4 to about 9. In some instances, the cationic surfactant has a net positive charge at a pH of about 4 to about 8, about 4 to about 7, about 4 to about 6, about 4 to about 5, about 5 to about 9, about 5 to about 8, about 5 to about 7, about 5 to about 6, about 6 to about 9, about 6 to about 8, about 6 to about 7, about 7 to about 9, about 7 to about 8, orabout 8 to about 9.

[0120] In some instances, the surfactant is present at a concentration of about 0.5% (w / w) to about 20% (w / w) of a total weight of the composition. In some embodiments, the surfactant is present at a concentration of about 0.5% (w / w) to about 20% (w / w), about 0.5% (w / w) to about 19% (w / w), about 0.5% (w / w) to about 18% (w / w), about 0.5% (w / w) to about 17% (w / w), about 0.5% (w / w) to about 16% (w / w), about 0.5% (w / w) to about 15% (w / w), about 0.5% (w / w) to about 14% (w / w), about 0.5% (w / w) to about 13% (w / w), about 0.5% (w / w) to about 12% (w / w), about 0.5% (w / w) to about 11% (w / w), about 0.5% (w / w) to about 10% (w / w), about 0.5% (w / w) to about 9% (w / w), about 0.5% (w / w) to about 8% (w / w), about 0.5% (w / w) to about 7% (w / w), about 0.5% (w / w) to about 6% (w / w), about 0.5% (w / w) to about 5% (w / w), about 0.5% (w / w) to about 4% (w / w), about 0.5% (w / w) to about 3% (w / w), about 0.5% (w / w) to about 2% (w / w), about 0.5% (w / w) to about 1% (w / w), about 1% (w / w) to about 20% (w / w), about 1% (w / w) to about 19% (w / w), about 1% (w / w) to about 18% (w / w), about 1% (w / w) to about 17% (w / w), about 1% (w / w) to about 16% (w / w), about 1% (w / w) to about 15% (w / w), about 1% (w / w) to about 14% (w / w),Attorney Docket No.63230-732.601 about 1% (w / w) to about 13% (w / w), about 1% (w / w) to about 12% (w / w), about 1% (w / w) to about 11% (w / w), about 1% (w / w) to about 10% (w / w), about 1% (w / w) to about 9% (w / w), about 1% (w / w) to about 8% (w / w), about 1% (w / w) to about 7% (w / w), about 1% (w / w) to about 6% (w / w), about 1% (w / w) to about 5% (w / w), about 1% (w / w) to about 4% (w / w), about 1% (w / w) to about 3% (w / w), about 1% (w / w) to about 2% (w / w), about 2% (w / w) to about 20% (w / w), about 2% (w / w) to about 19% (w / w), about 2% (w / w) to about 18% (w / w), about 2% (w / w) to about 17% (w / w), about 2% (w / w) to about 16% (w / w), about 2% (w / w) to about 15% (w / w), about 2% (w / w) to about 14% (w / w), about 2% (w / w) to about 13% (w / w), about 2% (w / w) to about 12% (w / w), about 2% (w / w) to about 11% (w / w), about 2% (w / w) to about 10% (w / w), about 2% (w / w) to about 9% (w / w), about 2% (w / w) to about 8% (w / w), about 2% (w / w) to about 7% (w / w), about 2% (w / w) to about 6% (w / w), about 2% (w / w) to about 5% (w / w), about 2% (w / w) to about 4% (w / w), about 2% (w / w) to about 3% (w / w), about 3% (w / w) to about 20% (w / w), about 3% (w / w) to about 19% (w / w), about 3% (w / w) to about 18% (w / w), about 3% (w / w) to about 17% (w / w), about 3% (w / w) to about 16% (w / w), about 3% (w / w) to about 15% (w / w), about 3% (w / w) to about 14% (w / w), about 3% (w / w) to about 13% (w / w), about 3% (w / w) to about 12% (w / w), about 3% (w / w) to about 11% (w / w), about 3% (w / w) to about 10% (w / w), about 3% (w / w) to about 9% (w / w), about 3% (w / w) to about 8% (w / w), about 3% (w / w) to about 7% (w / w), about 3% (w / w) to about 6% (w / w), about 3% (w / w) to about 5% (w / w), about 3% (w / w) to about 4% (w / w), about 4% (w / w) to about 20% (w / w), about 4% (w / w) to about 19% (w / w), about 4% (w / w) to about 18% (w / w), about 4% (w / w) to about 17% (w / w), about 4% (w / w) to about 16% (w / w), about 4% (w / w) to about 15% (w / w), about 4% (w / w) to about 14% (w / w), about 4% (w / w) to about 13% (w / w), about 4% (w / w) to about 12% (w / w), about 4% (w / w) to about 11% (w / w), about 4% (w / w) to about 10% (w / w), about 4% (w / w) to about 9% (w / w), about 4% (w / w) to about 8% (w / w), about 4% (w / w) to about 7% (w / w), about 4% (w / w) to about 6% (w / w), about 4% (w / w) to about 5% (w / w), about 5% (w / w) to about 20% (w / w), about 5% (w / w) to about 19% (w / w), about 5% (w / w) to about 18% (w / w), about 5% (w / w) to about 17% (w / w), about 5% (w / w) to about 16% (w / w), about 5% (w / w) to about 15% (w / w), about 5% (w / w) to about 14% (w / w), about 5% (w / w) to about 13% (w / w), about 5% (w / w) to about 12% (w / w), about 5% (w / w) to about 11% (w / w), about 5% (w / w) to about 10% (w / w), about 5% (w / w) to about 9% (w / w), about 5% (w / w) to about 8% (w / w), about 5% (w / w) to about 7% (w / w), about 5% (w / w) to about 6% (w / w), about 6% (w / w) to about 20% (w / w), about 6% (w / w) to about 19% (w / w), about 6% (w / w) to about 18% (w / w), about 6% (w / w) to about 17% (w / w), about 6% (w / w) to about 16% (w / w), about 6% (w / w) to about 15% (w / w), about 6% (w / w) to about 14% (w / w), about 6% (w / w) to about 13% (w / w), about 6% (w / w) to about 12% (w / w), about 6% (w / w) to about 11% (w / w), about 6% (w / w) to about 10% (w / w),Attorney Docket No.63230-732.601 about 6% (w / w) to about 9% (w / w), about 6% (w / w) to about 8% (w / w), about 6% (w / w) to about 7% (w / w), about 7% (w / w) to about 20% (w / w), about 7% (w / w) to about 19% (w / w), about 7% (w / w) to about 18% (w / w), about 7% (w / w) to about 17% (w / w), about 7% (w / w) to about 16% (w / w), about 7% (w / w) to about 15% (w / w), about 7% (w / w) to about 14% (w / w), about 7% (w / w) to about 13% (w / w), about 7% (w / w) to about 12% (w / w), about 7% (w / w) to about 11% (w / w), about 7% (w / w) to about 10% (w / w), about 7% (w / w) to about 9% (w / w), about 7% (w / w) to about 8% (w / w), about 8% (w / w) to about 20% (w / w), about 8% (w / w) to about 19% (w / w), about 8% (w / w) to about 18% (w / w), about 8% (w / w) to about 17% (w / w), about 8% (w / w) to about 16% (w / w), about 8% (w / w) to about 15% (w / w), about 8% (w / w) to about 14% (w / w), about 8% (w / w) to about 13% (w / w), about 8% (w / w) to about 12% (w / w), about 8% (w / w) to about 11% (w / w), about 8% (w / w) to about 10% (w / w), about 8% (w / w) to about 9% (w / w), about 9% (w / w) to about 20% (w / w), about 9% (w / w) to about 19% (w / w), about 9% (w / w) to about 18% (w / w), about 9% (w / w) to about 17% (w / w), about 9% (w / w) to about 16% (w / w), about 9% (w / w) to about 15% (w / w), about 9% (w / w) to about 14% (w / w), about 9% (w / w) to about 13% (w / w), about 9% (w / w) to about 12% (w / w), about 9% (w / w) to about 11% (w / w), about 9% (w / w) to about 10% (w / w), about 10% (w / w) to about 20% (w / w), about 10% (w / w) to about 19% (w / w), about 10% (w / w) to about 18% (w / w), about 10% (w / w) to about 17% (w / w), about 10% (w / w) to about 16% (w / w), about 10% (w / w) to about 15% (w / w), about 10% (w / w) to about 14% (w / w), about 10% (w / w) to about 13% (w / w), about 10% (w / w) to about 12% (w / w), about 10% (w / w) to about 11% (w / w), about 11% (w / w) to about 20% (w / w), about 11% (w / w) to about 19% (w / w), about 11% (w / w) to about 18% (w / w), about 11% (w / w) to about 17% (w / w), about 11% (w / w) to about 16% (w / w), about 11% (w / w) to about 15% (w / w), about 11% (w / w) to about 14% (w / w), about 11% (w / w) to about 13% (w / w), about 11% (w / w) to about 12% (w / w), about 12% (w / w) to about 20% (w / w), about 12% (w / w) to about 19% (w / w), about 12% (w / w) to about 18% (w / w), about 12% (w / w) to about 17% (w / w), about 12% (w / w) to about 16% (w / w), about 12% (w / w) to about 15% (w / w), about 12% (w / w) to about 14% (w / w), about 12% (w / w) to about 13% (w / w), about 13% (w / w) to about 20% (w / w), about 13% (w / w) to about 19% (w / w), about 13% (w / w) to about 18% (w / w), about 13% (w / w) to about 17% (w / w), about 13% (w / w) to about 16% (w / w), about 13% (w / w) to about 15% (w / w), about 13% (w / w) to about 14% (w / w), about 14% (w / w) to about 20% (w / w), about 14% (w / w) to about 19% (w / w), about 14% (w / w) to about 18% (w / w), about 14% (w / w) to about 17% (w / w), about 14% (w / w) to about 16% (w / w), about 14% (w / w) to about 15% (w / w), about 15% (w / w) to about 20% (w / w), about 15% (w / w) to about 19% (w / w), about 15% (w / w) to about 18% (w / w), about 15% (w / w) to about 17% (w / w), about 15% (w / w) to about 16% (w / w), about 16% (w / w) to about 20% (w / w), about 16% (w / w) to about 19% (w / w), about 16% (w / w) toAttorney Docket No.63230-732.601 about 18% (w / w), about 16% (w / w) to about 17% (w / w), about 17% (w / w) to about 20% (w / w), about 17% (w / w) to about 19% (w / w), about 17% (w / w) to about 18% (w / w), about 18% (w / w) to about 20% (w / w), about 18% (w / w) to about 19% (w / w), or about 19% (w / w) to about 20% (w / w) of a total weight of the composition.

[0121] In some instances, the first surfactant is present at a concentration of about 0.5% (w / w) to about 5% (w / w) of a total weight of the composition. In some instances, the first surfactant is present at a concentration of about 0.5% (w / w) to about 5% (w / w), about 0.5% (w / w) to about 4.5% (w / w), about 0.5% (w / w) to about 4% (w / w), about 0.5% (w / w) to about 3.5% (w / w), about 0.5% (w / w) to about 3% (w / w), about 0.5% (w / w) to about 2.5% (w / w), about 0.5% (w / w) to about 2% (w / w), about 0.5% (w / w) to about 1.5% (w / w), about 0.5% (w / w) to about 1% (w / w), about 1% (w / w) to about 5% (w / w), about 1% (w / w) to about 4.5% (w / w), about 1% (w / w) to about 4% (w / w), about 1% (w / w) to about 3.5% (w / w), about 1% (w / w) to about 3% (w / w), about 1% (w / w) to about 2.5% (w / w), about 1% (w / w) to about 2% (w / w), about 1% (w / w) to about 1.5% (w / w), about 1.5% (w / w) to about 5% (w / w), about 1.5% (w / w) to about 4.5% (w / w), about 1.5% (w / w) to about 4% (w / w), about 1.5% (w / w) to about 3.5% (w / w), about 1.5% (w / w) to about 3% (w / w), about 1.5% (w / w) to about 2.5% (w / w), about 1.5% (w / w) to about 2% (w / w), about 2% (w / w) to about 5% (w / w), about 2% (w / w) to about 4.5% (w / w), about 2% (w / w) to about 4% (w / w), about 2% (w / w) to about 3.5% (w / w), about 2% (w / w) to about 3% (w / w), about 2% (w / w) to about 2.5% (w / w), about 2.5% (w / w) to about 5% (w / w), about 2.5% (w / w) to about 4.5% (w / w), about 2.5% (w / w) to about 4% (w / w), about 2.5% (w / w) to about 3.5% (w / w), about 2.5% (w / w) to about 3% (w / w), about 3% (w / w) to about 5% (w / w), about 3% (w / w) to about 4.5% (w / w), about 3% (w / w) to about 4% (w / w), about 3% (w / w) to about 3.5% (w / w), about 3.5% (w / w) to about 5% (w / w), about 3.5% (w / w) to about 4.5% (w / w), about 3.5% (w / w) to about 4% (w / w), about 4% (w / w) to about 5% (w / w), about 4% (w / w) to about 4.5% (w / w), or about 4.5% (w / w) to about 5% (w / w) of a total weight of the composition.

[0122] In some instances, the second surfactant is present at a concentration of about 5% (w / w) to about 20% (w / w) of a total weight of the composition. In some instances, the second surfactant is present at a concentration of about 5% (w / w) to about 20% (w / w), about 5% (w / w) to about 19% (w / w), about 5% (w / w) to about 18% (w / w), about 5% (w / w) to about 17% (w / w), about 5% (w / w) to about 16% (w / w), about 5% (w / w) to about 15% (w / w), about 5% (w / w) to about 14% (w / w), about 5% (w / w) to about 13% (w / w), about 5% (w / w) to about 12% (w / w), about 5% (w / w) to about 11% (w / w), about 5% (w / w) to about 10% (w / w), about 5% (w / w) to about 9% (w / w), about 5% (w / w) to about 8% (w / w), about 5% (w / w) to about 7% (w / w), about 5% (w / w) to about 6% (w / w), about 6% (w / w) to about 20% (w / w), about 6% (w / w) to about 19% (w / w), about 6% (w / w)Attorney Docket No.63230-732.601 to about 18% (w / w), about 6% (w / w) to about 17% (w / w), about 6% (w / w) to about 16% (w / w), about 6% (w / w) to about 15% (w / w), about 6% (w / w) to about 14% (w / w), about 6% (w / w) to about 13% (w / w), about 6% (w / w) to about 12% (w / w), about 6% (w / w) to about 11% (w / w), about 6% (w / w) to about 10% (w / w), about 6% (w / w) to about 9% (w / w), about 6% (w / w) to about 8% (w / w), about 6% (w / w) to about 7% (w / w), about 7% (w / w) to about 20% (w / w), about 7% (w / w) to about 19% (w / w), about 7% (w / w) to about 18% (w / w), about 7% (w / w) to about 17% (w / w), about 7% (w / w) to about 16% (w / w), about 7% (w / w) to about 15% (w / w), about 7% (w / w) to about 14% (w / w), about 7% (w / w) to about 13% (w / w), about 7% (w / w) to about 12% (w / w), about 7% (w / w) to about 11% (w / w), about 7% (w / w) to about 10% (w / w), about 7% (w / w) to about 9% (w / w), about 7% (w / w) to about 8% (w / w), about 8% (w / w) to about 20% (w / w), about 8% (w / w) to about 19% (w / w), about 8% (w / w) to about 18% (w / w), about 8% (w / w) to about 17% (w / w), about 8% (w / w) to about 16% (w / w), about 8% (w / w) to about 15% (w / w), about 8% (w / w) to about 14% (w / w), about 8% (w / w) to about 13% (w / w), about 8% (w / w) to about 12% (w / w), about 8% (w / w) to about 11% (w / w), about 8% (w / w) to about 10% (w / w), about 8% (w / w) to about 9% (w / w), about 9% (w / w) to about 20% (w / w), about 9% (w / w) to about 19% (w / w), about 9% (w / w) to about 18% (w / w), about 9% (w / w) to about 17% (w / w), about 9% (w / w) to about 16% (w / w), about 9% (w / w) to about 15% (w / w), about 9% (w / w) to about 14% (w / w), about 9% (w / w) to about 13% (w / w), about 9% (w / w) to about 12% (w / w), about 9% (w / w) to about 11% (w / w), about 9% (w / w) to about 10% (w / w), about 10% (w / w) to about 20% (w / w), about 10% (w / w) to about 19% (w / w), about 10% (w / w) to about 18% (w / w), about 10% (w / w) to about 17% (w / w), about 10% (w / w) to about 16% (w / w), about 10% (w / w) to about 15% (w / w), about 10% (w / w) to about 14% (w / w), about 10% (w / w) to about 13% (w / w), about 10% (w / w) to about 12% (w / w), about 10% (w / w) to about 11% (w / w), about 11% (w / w) to about 20% (w / w), about 11% (w / w) to about 19% (w / w), about 11% (w / w) to about 18% (w / w), about 11% (w / w) to about 17% (w / w), about 11% (w / w) to about 16% (w / w), about 11% (w / w) to about 15% (w / w), about 11% (w / w) to about 14% (w / w), about 11% (w / w) to about 13% (w / w), about 11% (w / w) to about 12% (w / w), about 12% (w / w) to about 20% (w / w), about 12% (w / w) to about 19% (w / w), about 12% (w / w) to about 18% (w / w), about 12% (w / w) to about 17% (w / w), about 12% (w / w) to about 16% (w / w), about 12% (w / w) to about 15% (w / w), about 12% (w / w) to about 14% (w / w), about 12% (w / w) to about 13% (w / w), about 13% (w / w) to about 20% (w / w), about 13% (w / w) to about 19% (w / w), about 13% (w / w) to about 18% (w / w), about 13% (w / w) to about 17% (w / w), about 13% (w / w) to about 16% (w / w), about 13% (w / w) to about 15% (w / w), about 13% (w / w) to about 14% (w / w), about 14% (w / w) to about 20% (w / w), about 14% (w / w) to about 19% (w / w), about 14% (w / w) to about 18% (w / w), about 14% (w / w) to about 17% (w / w), about 14% (w / w) to about 16% (w / w), aboutAttorney Docket No.63230-732.601 14% (w / w) to about 15% (w / w), about 15% (w / w) to about 20% (w / w), about 15% (w / w) to about 19% (w / w), about 15% (w / w) to about 18% (w / w), about 15% (w / w) to about 17% (w / w), about 15% (w / w) to about 16% (w / w), about 16% (w / w) to about 20% (w / w), about 16% (w / w) to about 19% (w / w), about 16% (w / w) to about 18% (w / w), about 16% (w / w) to about 17% (w / w), about 17% (w / w) to about 20% (w / w), about 17% (w / w) to about 19% (w / w), about 17% (w / w) to about 18% (w / w), about 18% (w / w) to about 20% (w / w), about 18% (w / w) to about 19% (w / w), or about 19% (w / w) to about 20% (w / w) of a total weight of the composition.

[0123] In some instances, the first surfactant and the second surfactant are present in a mass ratio of about 1:1, about 1:2, about 1:3, about 1:4, about 1:5, about 1:10, about 1:15, about 1:20, about 1:25, about 1:30, about 1:35 or about 1:40. In some instances, the first surfactant and the second surfactant are present in a mass ratio of about 1:1, about 1:1.5, about 1:2, about 1:2.5, about 1:3, about 1:3.5, about 1:4, about 1:4.5, about 1:5, about 1:5.5, about 1:6, about 1:6.5, about 1:7, about 1:7.5, about 1:8, about 1:8.5, about 1:9, about 1:9.5, about 1:10, about 1:10.5, about 1:11, about 1:11.5, about 1:12, about 1:12.5, about 1:13, about 1:13.5, about 1:14, about 1:14.5, about 1:15, about 1:15.5, about 1:16, about 1:16.5, about 1:17, about 1:17.5, about 1:18, about 1:18.5, about 1:19, about 1:19.5, about 1:20, about 1:21, about 1:22, about 1:23, about 1:24, about 1:25, about 1:26, about 1:27, about 1:28, about 1:29, about 1:30, about 1:31, about 1:32, about 1:33, about 1:34, about 1:35, about 1:36, about 1:37, about 1:38, about 1:39, or about 1:40. Anti-Redeposition Agent

[0124] In some embodiments, the composition for removing metals from hair as described herein comprises at least one anti-redeposition agent or anti-redeposition polymer. In some instances, the terms “anti-redeopisition agent” and “anti-redeposition polymer” are used interchanglebly. In some instances, as described herein, the anti-redeposition agent prevents metals or metal ions from redepositing on hair. In some instances, the anti-redeposition agent may interact with a metal ion or a metal ion complexed with the at least one chelating agent. In some embodiments, the at least one anti-redeposition agent prevents precipitation of the metal ion or of the metal ion complexed with the at least one chelating agent. In some embodiments, the at least one anti-redeposition agent comprises a plurality of negative charges. In some instances, the plurality of negative charges interacts with the metal ion or the metal ion complexed with the at least one chelating agent. at least one chelating agent. In some instances, the anti-redeposition polymer forms a coating adjacent to the hair, thereby decreasing metal deposition onto hair.

[0125] In some embodiments, the at least one anti-redeposition agent play a role in demineralizing or chelating capacity of the composition for removing metals from hair. In some embodiments, the at least one anti-redeposition agent inhibit calcium carbonate (CaCO3) precipitation. In someAttorney Docket No.63230-732.601 embodiments, the at least one anti-redeposition agent keep metal ions dispersed in water, so the metal ions do not re-deposit on hair. In some embodiments, the at least one anti-redeposition agent prevents metal ions, metal / chelator complexes, or a combination thereof. In some embodiments, the at least one anti-redeposition agent comprises a plurality of negatively charged groups. In some embodiments, the plurality of negatively charged groups coordinates to a metal or metal ion. In some embodiments, each of the plurality of negatively charged groups coordinates to one metal or metal ion. In some embodiments, at least two negatively charged groups coordinates to one metal or metal ion. In some embodiments, each of the plurality of negatively charged groups coordinates to at least one metal or metal ion. In some instances, the anti-redeposition agent comprises one or more functional groups having a net negative charge at a pH of about 4 to about 9, wherein the one or more functional groups chelates to a metal.

[0126] In some instances, the composition for removing metals from hair as described herein comprises at least one anti-redeposition agent. In some embodiments, the at least one anti- redeposition agent disclosed herein comprise a rheology modifier, e.g., thickener, a biodegradable functionalized biopolymer, or an anionic functionalized biopolymer. In some instances, the at least one anti-redeposition agent comprises an anionic functionalized biopolymer having sequestering capacity.

[0127] In some embodiments, the composition described herein comprises an anti-redeposition agent comprises an anionic functionalized biopolymer having sequestering capacity. In some instances, anti-redeposition agent forms a layer adjacent to a hair.

[0128] In some instances, the at least one anti-redeposition agent comprises a polymer, or a silicate, or a combination thereof. In some instances, the polymer comprises a polypeptide, a polyacrylamide, a polyacrylamide / acrylamidopropyltrimonium copolymer, a polyquaternium, a polysaccharide, or a combination thereof. In some instances, the at least one anti-redeposition agent comprises a polymer, or a silicate, or a combination thereof, wherein the polymer comprises a polypeptide, a polyacrylamide, a polyacrylamide / acrylamidopropyltrimonium copolymer, a polyquaternium, a polysaccharide, or a combination thereof.

[0129] In some instances, polypeptide comprises polyaspartate, polyglutamate, polyalanine, polyserine, polyarginine, or polylysine, or a combination thereof.

[0130] In some instances, the polyquaternium comprises polyquaternium-2, polyquaternium-4, polyquaternium-7, polyquaternium-10, polyquaternium-17, polyquaternium-18, polyquaternium- 24, polyquaternium-27, polyquaternium-28, polyquaternium-32, polyquaternium,-33, polyquaternium-37, polyquaternium-55, polyquaternium-60, or polyquaternium-113, or a combination thereof.Attorney Docket No.63230-732.601

[0131] In some instances, the polysaccharide comprises sodium carboxymethyl inulin, xanthan gum, hydroxyethylcellulose, hydroxymethylcellulose, cellulose, cellulose gum, microcrystalline cellulose, carboxymethylcellulose, pullulan, sclerotium gum, tetragonoloba (guar) gum, acacia senegal gum, hydroxypropyl starch phosphate, or a combination thereof.

[0132] In some instances, the silicate comprises lithium magnesium sodium silicate, sodium magnesium fluorosilicate, magnesium aluminum silicate, or a combination thereof.

[0133] In some instances, the at least one anti-redeposition agent comprises a polyacrylamide / acrylamidopropyltrimonium copolymer, polyaspartate, polyglutamate, polyalanine, polyserine, polyarginine, polylysine, polyquaternium-2, polyquaternium-4, polyquaternium-7, polyquaternium-10, polyquaternium-17, polyquaternium-18, polyquaternium-24, polyquaternium- 27, polyquaternium-28, polyquaternium-32, polyquaternium,-33, polyquaternium-37, polyquaternium-55, polyquaternium-60, or polyquaternium-113, sodium carboxymethyl inulin, xanthan gum, hydroxyethylcellulose, hydroxymethylcellulose, cellulose, cellulose gum, microcrystalline cellulose, carboxymethylcellulose, pullulan, sclerotium gum, tetragonoloba (guar) gum, acacia senegal gum, hydroxypropyl starch phosphate, lithium magnesium sodium silicate, sodium magnesium fluorosilicate, or a combination thereof.

[0134] In some embodiments, the at least one anti-redeposition agent comprises a thickener. In some instances, the thickener comprises lauryl lactate, hydroxypropyl starch phosphate, acrylates copolymer, ammonium acryloyldimethyltaurate, sodium acryloyldimethyltaurate / VP copolymer, sodium acrylate / sodium acryloyldimethyl taurate copolymer, sodium polyacrylate, polyacrylate crosspolymer-11, carbomer, acrylates / C10-30 alkyl acrylate crosspolymer, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, lithium magnesium sodium silicate, sodium magnesium fluorosilicate, glycol distearate, hydrogenated castor oil, hydrogenated castor oil hydroxystearate, hydrogenated castor oil isostearate, hydrogenated castor oil stearate, hydrogenated castor PEG-8 esters, or a combination thereof.

[0135] In some embodiments, the at least one anti-redeposition agent comprises a polysaccharide, a silicate, or a combination thereof. In some embodiments, the polysaccharide comprises sodium carboxymethyl inulin, xanthan gum, hydroxyethylcellulose, hydroxymethylcellulose, cellulose, cellulose gum, microcrystalline cellulose, carboxymethylcellulose, pullulan, sclerotium gum, tetragonoloba (guar) gum, acacia senegal gum, hydroxypropyl starch phosphate, or a combination thereof. In some embodiments, the silicate comprises lithium magnesium sodium silicate, sodium magnesium fluorosilicate, magnesium aluminum silicate, or a combination thereof.

[0136] In some embodiments, the at least one anti-redeposition agent comprising sodium carboxymethyl inulin, xanthan gum, hydroxyethylcellulose, hydroxymethylcellulose, cellulose,Attorney Docket No.63230-732.601 cellulose gum, microcrystalline cellulose, carboxymethylcellulose, pullulan, sclerotium gum, tetragonoloba (guar) gum, acacia senegal gum, hydroxypropyl starch phosphate, lithium magnesium sodium silicate, sodium magnesium fluorosilicate, or a combination thereof. In some embodiments, the anti-redeposition agents comprise sodium carboxymethyl inulin.

[0137] In some embodiments, the total concentration (%w / w) of the at least one anti-redeposition agent in the composition for removing metals from hair is about 0.005% to about 10%, about 0.01% to about 10%, about 0.05% to about 10%, about 0.1% to about 10%, about 0.2% to about 10%, about 0.3% to about 10%, about 0.4% to about 10%, about 0.5% to about 10%, about 0.6% to about 10%, about 0.7% to about 10%, about 0.8% to about 10%, about 0.9% to about 10%, about 1% to about 10%, about 1.5% to about 10%, about 2% to about 10%, about 2.5% to about 10%, about 3% to about 10%, about 3.5% to about 10%, about 4% to about 10%, or about 4.5% to about 10%. In some embodiments, the total concentration (%w / w) of the at least one anti-redeposition agent in the composition for removing metals from hair is about 0.005% to about 5%, about 0.01% to about 5%, about 0.05% to about 5%, about 0.1% to about 5%, about 0.2% to about 5%, about 0.3% to about 5%, about 0.4% to about 5%, about 0.5% to about 5%, about 0.6% to about 5%, about 0.7% to about 5%, about 0.8% to about 5%, about 0.9% to about 5%, about 1% to about 5%, about 1.5% to about 5%, about 2% to about 5%, about 2.5% to about 5%, about 3% to about 5%, about 3.5% to about 5%, about 4% to about 5%, or about 4.5% to about 5%. In some embodiments, the concentration (%w / w) of each of the at least one anti-redeposition agent in the composition for removing metals from hair is about 0.005%, about 0.01%, about 0.05%, about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, about 10%, or any values therebetween. In some embodiments, the total concentration (%w / w) of the at least one anti-redeposition agent in the composition for removing metals from hair is at least about 0.005%, at least about 0.01%, at least about 0.05%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.5%, at least about 2%, at least about 2.5%, at least about 3%, at least about 3.5%, at least about 4%, at least about 4.5%, at least about 5%, at least about 5.5%, at least about 6%, at least about 6.5%, at least about 7%, at least about 7.5%, at least about 8%, at least about 8.5%, at least about 9%, at least about 9.5%, or at least about 10%. In some embodiments, the total concentration (%w / w) of the at least one anti-redeposition agent in the composition for removing metals from hair is at most about 0.005%, at most about 0.01%, at most about 0.05%, at most about 0.1%, at most about 0.2%, atAttorney Docket No.63230-732.601 most about 0.3%, at most about 0.4%, at most about 0.5%, at most about 0.6%, at most about 0.7%, at most about 0.8%, at most about 0.9%, at most about 1%, at most about 1.5%, at most about 2%, at most about 2.5%, at most about 3%, at most about 3.5%, at most about 4%, at most about 4.5%, at most about 5%, at most about 5.5%, at most about 6%, at most about 6.5%, at most about 7%, at most about 7.5%, at most about 8%, at most about 8.5%, at most about 9%, at most about 9.5%, or at most about 10%. In some embodiments, the concentration (%w / w) of the at least one anti- redeposition agent in the composition for removing metals from hair is about 0.01% to about 10%, about 0.05% to about 9.5%, about 0.1% to about 9%, about 0.2% to about 8.5%, about 0.3% to about 8%, about 0.4% to about 7.5%, about 0.5% to about 7%, about 0.6% to about 6.5%, about 0.7% to about 6%, about 0.8% to about 5.5%, about 0.9% to about 5%, about 1% to about 4.5%, about 1.5% to about 4%, about 2% to about 3.5%, or about 2.5% to about 3%.

[0138] In some embodiments, the concentration (%w / w) of sodium carboxymethyl inulin present in the composition for removing metals from hair is at about 0.005% to about 5% by weight, about 0.1% to about 2% by weight, about 0.5% to about 2% by weight, about 0.6% to about 2% by weight, about 0.7% to about 2% by weight, about 0.8% to about 2% by weight, about 0.9% to about 2% by weight, about 1% to about 2% by weight, about 1% to about 2% by weight, about 1.1% to about 2% by weight, about 1.2% to about 2% by weight, about 1.3% to about 2% by weight, about 1.4% to about 2% by weight, about 1.5% to about 2% by weight, 0.5% to about 1% by weight, about 0.6% to about 1% by weight, about 0.7% to about 1% by weight, about 0.8% to about 1% by weight, or about 0.9% to about 1% by weight. In some instances, the concentration (%w / w) of sodium carboxymethyl inulin is at about 0.005%, about 0.01%, about 0.05%, about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, about 5.5%, about 6%, about 6.5%, about 7%, about 7.5%, about 8%, about 8.5%, about 9%, about 9.5%, or about 10%, by weight of the composition for removing metals from hair. In some instances, the concentration (%w / w) of sodium carboxymethyl inulin is at least about 0.005%, at least about 0.01%, at least about 0.05%, at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.5%, at least about 2%, at least about 2.5%, at least about 3%, at least about 3.5%, at least about 4%, at least about 4.5%, at least about 5%, at least about 5.5%, at least about 6%, at least about 6.5%, at least about 7%, at least about 7.5%, at least about 8%, at least about 8.5%, at least about 9%, at least about 9.5%, or at least about 10%. In some instances, the concentration (%w / w) of sodium carboxymethyl inulin is at most about 0.005%, at most about 0.01%, at most about 0.05%, at most about 0.1%, at most about 0.2%,Attorney Docket No.63230-732.601 at most about 0.3%, at most about 0.4%, at most about 0.5%, at most about 0.6%, at most about 0.7%, at most about 0.8%, at most about 0.9%, at most about 1%, at most about 1.5%, at most about 2%, at most about 2.5%, at most about 3%, at most about 3.5%, at most about 4%, at most about 4.5%, at most about 5%, at most about 5.5%, at most about 6%, at most about 6.5%, at most about 7%, at most about 7.5%, at most about 8%, at most about 8.5%, at most about 9%, at most about 9.5%, or at most about 10%.

[0139] In some instances, the anti-redeposition agent is present at a concentration of about 1% (w / w) to about 5% (w / w) of a total weight of the composition. In some instances, the anti- redeposition agent is present at a concentration of about 1% (w / w) to about 5% (w / w), about 1% (w / w) to about 4.5% (w / w), about 1% (w / w) to about 4% (w / w), about 1% (w / w) to about 3.5% (w / w), about 1% (w / w) to about 3% (w / w), about 1% (w / w) to about 2.5% (w / w), about 1% (w / w) to about 2% (w / w), about 1% (w / w) to about 1.5% (w / w), about 1.5% (w / w) to about 5% (w / w), about 1.5% (w / w) to about 4.5% (w / w), about 1.5% (w / w) to about 4% (w / w), about 1.5% (w / w) to about 3.5% (w / w), about 1.5% (w / w) to about 3% (w / w), about 1.5% (w / w) to about 2.5% (w / w), about 1.5% (w / w) to about 2% (w / w), about 2% (w / w) to about 5% (w / w), about 2% (w / w) to about 4.5% (w / w), about 2% (w / w) to about 4% (w / w), about 2% (w / w) to about 3.5% (w / w), about 2% (w / w) to about 3% (w / w), about 2% (w / w) to about 2.5% (w / w), about 2.5% (w / w) to about 5% (w / w), about 2.5% (w / w) to about 4.5% (w / w), about 2.5% (w / w) to about 4% (w / w), about 2.5% (w / w) to about 3.5% (w / w), about 2.5% (w / w) to about 3% (w / w), about 3% (w / w) to about 5% (w / w), about 3% (w / w) to about 4.5% (w / w), about 3% (w / w) to about 4% (w / w), about 3% (w / w) to about 3.5% (w / w), about 3.5% (w / w) to about 5% (w / w), about 3.5% (w / w) to about 4.5% (w / w), about 3.5% (w / w) to about 4% (w / w), about 4% (w / w) to about 5% (w / w), about 4% (w / w) to about 4.5% (w / w), or about 4.5% (w / w) to about 5% (w / w) of a total weight of the composition.In some instances, the anti-redeposition agent and the chelator composition are present in a mass ratio of about 1:2, about 1:5, about 1:10, about 1.5:2, about 1.5: 2.1, about 1.5: 2.2, about 1.5:2.3, about 1.5:2.4, about 1.5:2.5, about 1.5:2.6, about 1.5:2.7, about 1.5:2.8, about 1.5: 2.9, about 2:2.1, about 2:2.2, about 2:2.3, about 2:2.4, about 2:2.5, about 2:2.6, about 2:2.7, about 2:2.8, about 2:2.9, about 2:3, or about 2:5. In some instances, the about 1:2, about 1:2.1, about 1:2.2, about 1:2.3, about 1:2.4, about 1:2.5, about 1:2.6, about 1:2.7, about 1:2.8, about 1:2.9, about 1:3, about 1:3.1, about 1:3.2, about 1:3.3, about 1:3.4, about 1:3.5, about 1:3.6, about 1:3.7, about 1:3.8, about 1:3.9, about 1:4, about 1:4.1, about 1:4.2, about 1:4.3, about 1:4.4, about 1:4.5, about 1:4.6, about 1:4.7, about 1:4.8, about 1:4.9, about 1:5, about 1:5.1, about 1:5.2, about 1:5.3, about 1:5.4, about 1:5.5, about 1:5.6, about 1:5.7, about 1:5.8, about 1:5.9, about 1:6, about 1:6.1, about 1:6.2, about 1:6.3, about 1:6.4, about 1:6.5, about 1:6.6, about 1:6.7, about 1:6.8, about 1:6.9, about 1:7,Attorney Docket No.63230-732.601 about 1.5:2, about 1.5:2.1, about 1.5:2.2, about 1.5:2.3, about 1.5:2.4, about 1.5:2.5, about 1.5:2.6, about 1.5:2.7, about 1.5:2.8, about 1.5:2.9, about 1.5:3, about 1.5:3.1, about 1.5:3.2, about 1.5:3.3, about 1.5:3.4, about 1.5:3.5, about 1.5:3.6, about 1.5:3.7, about 1.5:3.8, about 1.5:3.9, about 1.5:4, about 1.5:4.1, about 1.5:4.2, about 1.5:4.3, about 1.5:4.4, about 1.5:4.5, about 1.5:4.6, about 1.5:4.7, about 1.5:4.8, about 1.5:4.9, about 1.5:5, about 1.5:5.1, about 1.5:5.2, about 1.5:5.3, about 1.5:5.4, about 1.5:5.5, about 1.5:5.6, about 1.5:5.7, about 1.5:5.8, about 1.5:5.9, about 1.5:6.1, about 1.5:6.2, about 1.5:6.3, about 1.5:6.4, about 1.5:6.5, about 1.5:6.6, about 1.5:6.7, about 1.5:6.8, about 1.5:6.9, about 1.5:7.0, about 2:2.1, about 2:2.2, about 2:2.3, about 2:2.4, about 2:2.5, about 2:2.6, about 2:2.7, about 2:2.8, about 2:2.9, about 2:3, about 2:3.1, about 2:3.2, about 2:3.3, about 2:3.4, about 2:3.5, about 2:3.6, about 2:3.7, about 2:3.8, about 2:3.9, about 2:4.1, about 2:4.2, about 2:4.3, about 2:4.4, about 2:4.5, about 2:4.6, about 2:4.7, about 2:4.8, about 2:4.9, about 2:5, about 2:5.1, about 2:5.2, about 2:5.3, about 2:5.4, about 2:5.5, about 2:5.6, about 2:5.7, about 2:5.8, about 2:5.9, about 2:6.1, about 2:6.2, about 2:6.3, about 2:6.4, about 2:6.5, about 2:6.6, about 2:6.7, about 2:6.8, about 2:6.9, or about 2:7. Toning Dye

[0140] In some instances, the composition described herein further comprises a toning dye. In some instances, the toning dye comprises a purple dye, a blue dye, a green dye, a red dye, a yellow dye, an orange dye, or a combination thereof. In some instances, the toning dye is present at a concentration of about 0.1% (w / w) to about 20% (w / w) of a total weight of the composition. In some instances, the toning dye is present at a concentration of about 0.1% (w / w) to about 20% (w / w), about 0.1% (w / w) to about 19% (w / w), about 0.1% (w / w) to about 18% (w / w), about 0.1% (w / w) to about 17% (w / w), about 0.1% (w / w) to about 16% (w / w), about 0.1% (w / w) to about 15% (w / w), about 0.1% (w / w) to about 14% (w / w), about 0.1% (w / w) to about 13% (w / w), about 0.1% (w / w) to about 12% (w / w), about 0.1% (w / w) to about 11% (w / w), about 0.1% (w / w) to about 10% (w / w), about 0.1% (w / w) to about 9% (w / w), about 0.1% (w / w) to about 8% (w / w), about 0.1% (w / w) to about 7% (w / w), about 0.1% (w / w) to about 6% (w / w), about 0.1% (w / w) to about 5% (w / w), about 0.1% (w / w) to about 4% (w / w), about 0.1% (w / w) to about 3% (w / w), about 0.1% (w / w) to about 2% (w / w), about 0.1% (w / w) to about 1% (w / w), about 0.2% (w / w) to about 20% (w / w), about 0.2% (w / w) to about 19% (w / w), about 0.2% (w / w) to about 18% (w / w), about 0.2% (w / w) to about 17% (w / w), about 0.2% (w / w) to about 16% (w / w), about 0.2% (w / w) to about 15% (w / w), about 0.2% (w / w) to about 14% (w / w), about 0.2% (w / w) to about 13% (w / w), about 0.2% (w / w) to about 12% (w / w), about 0.2% (w / w) to about 11% (w / w), about 0.2% (w / w) to about 10% (w / w), about 0.2% (w / w) to about 9% (w / w), about 0.2% (w / w) to about 8% (w / w), about 0.2% (w / w) to about 7% (w / w), about 0.2%Attorney Docket No.63230-732.601 (w / w) to about 6% (w / w), about 0.2% (w / w) to about 5% (w / w), about 0.2% (w / w) to about 4% (w / w), about 0.2% (w / w) to about 3% (w / w), about 0.2% (w / w) to about 2% (w / w), about 0.2% (w / w) to about 1% (w / w), about 0.5% (w / w) to about 20% (w / w), about 0.5% (w / w) to about 19% (w / w), about 0.5% (w / w) to about 18% (w / w), about 0.5% (w / w) to about 17% (w / w), about 0.5% (w / w) to about 16% (w / w), about 0.5% (w / w) to about 15% (w / w), about 0.5% (w / w) to about 14% (w / w), about 0.5% (w / w) to about 13% (w / w), about 0.5% (w / w) to about 12% (w / w), about 0.5% (w / w) to about 11% (w / w), about 0.5% (w / w) to about 10% (w / w), about 0.5% (w / w) to about 9% (w / w), about 0.5% (w / w) to about 8% (w / w), about 0.5% (w / w) to about 7% (w / w), about 0.5% (w / w) to about 6% (w / w), about 0.5% (w / w) to about 5% (w / w), about 0.5% (w / w) to about 4% (w / w), about 0.5% (w / w) to about 3% (w / w), about 0.5% (w / w) to about 2% (w / w), about 0.5% (w / w) to about 1% (w / w), about 1% (w / w) to about 20% (w / w), about 1% (w / w) to about 19% (w / w), about 1% (w / w) to about 18% (w / w), about 1% (w / w) to about 17% (w / w), about 1% (w / w) to about 16% (w / w), about 1% (w / w) to about 15% (w / w), about 1% (w / w) to about 14% (w / w), about 1% (w / w) to about 13% (w / w), about 1% (w / w) to about 12% (w / w), about 1% (w / w) to about 11% (w / w), about 1% (w / w) to about 10% (w / w), about 1% (w / w) to about 9% (w / w), about 1% (w / w) to about 8% (w / w), about 1% (w / w) to about 7% (w / w), about 1% (w / w) to about 6% (w / w), about 1% (w / w) to about 5% (w / w), about 1% (w / w) to about 4% (w / w), about 1% (w / w) to about 3% (w / w), about 1% (w / w) to about 2% (w / w), about 2% (w / w) to about 20% (w / w), about 2% (w / w) to about 19% (w / w), about 2% (w / w) to about 18% (w / w), about 2% (w / w) to about 17% (w / w), about 2% (w / w) to about 16% (w / w), about 2% (w / w) to about 15% (w / w), about 2% (w / w) to about 14% (w / w), about 2% (w / w) to about 13% (w / w), about 2% (w / w) to about 12% (w / w), about 2% (w / w) to about 11% (w / w), about 2% (w / w) to about 10% (w / w), about 2% (w / w) to about 9% (w / w), about 2% (w / w) to about 8% (w / w), about 2% (w / w) to about 7% (w / w), about 2% (w / w) to about 6% (w / w), about 2% (w / w) to about 5% (w / w), about 2% (w / w) to about 4% (w / w), about 2% (w / w) to about 3% (w / w), about 3% (w / w) to about 20% (w / w), about 3% (w / w) to about 19% (w / w), about 3% (w / w) to about 18% (w / w), about 3% (w / w) to about 17% (w / w), about 3% (w / w) to about 16% (w / w), about 3% (w / w) to about 15% (w / w), about 3% (w / w) to about 14% (w / w), about 3% (w / w) to about 13% (w / w), about 3% (w / w) to about 12% (w / w), about 3% (w / w) to about 11% (w / w), about 3% (w / w) to about 10% (w / w), about 3% (w / w) to about 9% (w / w), about 3% (w / w) to about 8% (w / w), about 3% (w / w) to about 7% (w / w), about 3% (w / w) to about 6% (w / w), about 3% (w / w) to about 5% (w / w), about 3% (w / w) to about 4% (w / w), about 4% (w / w) to about 20% (w / w), about 4% (w / w) to about 19% (w / w), about 4% (w / w) to about 18% (w / w), about 4% (w / w) to about 17% (w / w), about 4% (w / w) to about 16% (w / w), about 4% (w / w) to about 15% (w / w), about 4% (w / w) to about 14% (w / w), about 4% (w / w) to about 13% (w / w),Attorney Docket No.63230-732.601 about 4% (w / w) to about 12% (w / w), about 4% (w / w) to about 11% (w / w), about 4% (w / w) to about 10% (w / w), about 4% (w / w) to about 9% (w / w), about 4% (w / w) to about 8% (w / w), about 4% (w / w) to about 7% (w / w), about 4% (w / w) to about 6% (w / w), about 4% (w / w) to about 5% (w / w), about 5% (w / w) to about 20% (w / w), about 5% (w / w) to about 19% (w / w), about 5% (w / w) to about 18% (w / w), about 5% (w / w) to about 17% (w / w), about 5% (w / w) to about 16% (w / w), about 5% (w / w) to about 15% (w / w), about 5% (w / w) to about 14% (w / w), about 5% (w / w) to about 13% (w / w), about 5% (w / w) to about 12% (w / w), about 5% (w / w) to about 11% (w / w), about 5% (w / w) to about 10% (w / w), about 5% (w / w) to about 9% (w / w), about 5% (w / w) to about 8% (w / w), about 5% (w / w) to about 7% (w / w), about 5% (w / w) to about 6% (w / w), about 6% (w / w) to about 20% (w / w), about 6% (w / w) to about 19% (w / w), about 6% (w / w) to about 18% (w / w), about 6% (w / w) to about 17% (w / w), about 6% (w / w) to about 16% (w / w), about 6% (w / w) to about 15% (w / w), about 6% (w / w) to about 14% (w / w), about 6% (w / w) to about 13% (w / w), about 6% (w / w) to about 12% (w / w), about 6% (w / w) to about 11% (w / w), about 6% (w / w) to about 10% (w / w), about 6% (w / w) to about 9% (w / w), about 6% (w / w) to about 8% (w / w), about 6% (w / w) to about 7% (w / w), about 7% (w / w) to about 20% (w / w), about 7% (w / w) to about 19% (w / w), about 7% (w / w) to about 18% (w / w), about 7% (w / w) to about 17% (w / w), about 7% (w / w) to about 16% (w / w), about 7% (w / w) to about 15% (w / w), about 7% (w / w) to about 14% (w / w), about 7% (w / w) to about 13% (w / w), about 7% (w / w) to about 12% (w / w), about 7% (w / w) to about 11% (w / w), about 7% (w / w) to about 10% (w / w), about 7% (w / w) to about 9% (w / w), about 7% (w / w) to about 8% (w / w), about 8% (w / w) to about 20% (w / w), about 8% (w / w) to about 19% (w / w), about 8% (w / w) to about 18% (w / w), about 8% (w / w) to about 17% (w / w), about 8% (w / w) to about 16% (w / w), about 8% (w / w) to about 15% (w / w), about 8% (w / w) to about 14% (w / w), about 8% (w / w) to about 13% (w / w), about 8% (w / w) to about 12% (w / w), about 8% (w / w) to about 11% (w / w), about 8% (w / w) to about 10% (w / w), about 8% (w / w) to about 9% (w / w), about 9% (w / w) to about 20% (w / w), about 9% (w / w) to about 19% (w / w), about 9% (w / w) to about 18% (w / w), about 9% (w / w) to about 17% (w / w), about 9% (w / w) to about 16% (w / w), about 9% (w / w) to about 15% (w / w), about 9% (w / w) to about 14% (w / w), about 9% (w / w) to about 13% (w / w), about 9% (w / w) to about 12% (w / w), about 9% (w / w) to about 11% (w / w), about 9% (w / w) to about 10% (w / w), about 10% (w / w) to about 20% (w / w), about 10% (w / w) to about 19% (w / w), about 10% (w / w) to about 18% (w / w), about 10% (w / w) to about 17% (w / w), about 10% (w / w) to about 16% (w / w), about 10% (w / w) to about 15% (w / w), about 10% (w / w) to about 14% (w / w), about 10% (w / w) to about 13% (w / w), about 10% (w / w) to about 12% (w / w), about 10% (w / w) to about 11% (w / w), about 11% (w / w) to about 20% (w / w), about 11% (w / w) to about 19% (w / w), about 11% (w / w) to about 18% (w / w), about 11% (w / w) to about 17% (w / w), about 11% (w / w) to about 16% (w / w),Attorney Docket No.63230-732.601 about 11% (w / w) to about 15% (w / w), about 11% (w / w) to about 14% (w / w), about 11% (w / w) to about 13% (w / w), about 11% (w / w) to about 12% (w / w), about 12% (w / w) to about 20% (w / w), about 12% (w / w) to about 19% (w / w), about 12% (w / w) to about 18% (w / w), about 12% (w / w) to about 17% (w / w), about 12% (w / w) to about 16% (w / w), about 12% (w / w) to about 15% (w / w), about 12% (w / w) to about 14% (w / w), about 12% (w / w) to about 13% (w / w), about 13% (w / w) to about 20% (w / w), about 13% (w / w) to about 19% (w / w), about 13% (w / w) to about 18% (w / w), about 13% (w / w) to about 17% (w / w), about 13% (w / w) to about 16% (w / w), about 13% (w / w) to about 15% (w / w), about 13% (w / w) to about 14% (w / w), about 14% (w / w) to about 20% (w / w), about 14% (w / w) to about 19% (w / w), about 14% (w / w) to about 18% (w / w), about 14% (w / w) to about 17% (w / w), about 14% (w / w) to about 16% (w / w), about 14% (w / w) to about 15% (w / w), about 15% (w / w) to about 20% (w / w), about 15% (w / w) to about 19% (w / w), about 15% (w / w) to about 18% (w / w), about 15% (w / w) to about 17% (w / w), about 15% (w / w) to about 16% (w / w), about 16% (w / w) to about 20% (w / w), about 16% (w / w) to about 19% (w / w), about 16% (w / w) to about 18% (w / w), about 16% (w / w) to about 17% (w / w), about 17% (w / w) to about 20% (w / w), about 17% (w / w) to about 19% (w / w), about 17% (w / w) to about 18% (w / w), about 18% (w / w) to about 20% (w / w), about 18% (w / w) to about 19% (w / w), or about 19% (w / w) to about 20% (w / w) of a total weight of the composition. Antioxidant

[0141] In some instances, the compositions described herein comprises an antioxidant. Antioxidants are synthetic or naturally occurring molecules that inhibit oxidation reactions by neutralizing unpaired electrons of free radicals through a resonance-stabilized bonding network. They act as reactive oxygen species (ROS) scavengers to reduce oxidative damage. Some non- limiting examples of antioxidants include, but are not limited to, vitamin C (ascorbic acid) and vitamin E (alpha-tocopherol). In some embodiments, the at least one antioxidant reduces oxidation reactions on hair that are caused by secondary (trace) metals, which may remain after removal by the at least one chelating agent. In some embodiments, the at least one antioxidant is effective to reduce oxidation reactions under acidic conditions. In various embodiments, the at least one antioxidant works effectively under alkaline conditions to match an optimal activity of the at least one chelating agent. In some embodiments, the at least one antioxidant of the composition described herein may be effective at neutral or alkaline pH ranges. In some embodiments, the at least one antioxidant of the composition for removing metals from hair as described herein may be effective at pH of about 6 to about 9, for example, at pH of about 7 to about 8.

[0142] In some embodiments, the composition comprises at least one antioxidant. In some embodiments, the at least one antioxidant comprises a peptide-derived antioxidant. In someAttorney Docket No.63230-732.601 embodiments, the peptide-derived antioxidant comprises phenylalanine, valine, cysteine, alanine, histidine, or a combination thereof. In some embodiments, the at least one antioxidant comprises dipeptides of alanine and histidine. In some embodiments, the peptide-derived antioxidant comprises carnosine, valine-cysteine, di-proline, di-phenylalanine, or a combination thereof. In some embodiments, the peptide-derived antioxidant comprises carnosine. In some embodiments, the at least one antioxidant is a peptide-derived antioxidant. In some embodiments, the peptide- derived antioxidant is carnosine, valine-cysteine, di-proline, di-phenylalanine, or a combination thereof.

[0143] In some embodiments, the at least one antioxidant comprises carnosine, ascorbic acid, tetrahexyldecyl ascorbate, bioflavonoids, lycopene, Daucus carota sativa root cell culture lysate, monoammonium glycyrrhizinate, alpha lipoic acid (thioctic acid), Leontopodium alpinum (edelweiss) extract, Rosmarinus officinalis (rosemary) leaf extract, Vitis vinifera (grape) seed extract, Camellia sinensis leaf extract, Quercus robur wood extract, hydrolyzed olive fruit, Olea europea (olive) leaf extract, oleuropein, Punica granatum bark / fruit extract, punicalagin, ellagic acid, polyphenols, epigallocatechin (EGCG), tannins, sulforaphane, resveratrol, nordihydroguaiaretic acid, thioctic acid, or a combination thereof. In some instances, the antioxidant comprises carnosine, valine-cysteine, di-proline, di-phenylalanine, tocopherol, ascorbate, or a combination thereof.

[0144] In some embodiments, the composition for removing metals from hair as described herein comprises a chelator composition comprising at least one chelating agent, wherein the at least one chelating agent comprises trisodium MGDA, sodium gluconate, or tetrasodium EDTA, and at least one antioxidant comprising carnosine. In some embodiments, the composition for removing metals from hair as described herein comprises trisodium MGDA, sodium gluconate, tetrasodium EDTA, or carnosine.

[0145] In some embodiments, the total concentration (%w / w) of the at least one antioxidant in the composition for removing metals from hair as described herein is about 0.001% to about 5%, about 0.005% to about 5%, about 0.01% to about 5%, about 0.025% to about 5%, about 0.1% to about 5%, about 0.5% to about 5%, about 1% to about 5%, about 2% to about 5%, about 3% to about 5%, or about 4% to about 5%.

[0146] In some instances, the total concentration (%w / w) of the at least one antioxidant in the composition is about 0.1% (w / w) to about 10% (w / w) of a total weight of the composition. In some instances, the total concentration (%w / w) of the at least one antioxidant in the composition is about 0.1% (w / w) to about 10% (w / w), about 0.1% (w / w) to about 9% (w / w), about 0.1% (w / w) to about 8% (w / w), about 0.1% (w / w) to about 7% (w / w), about 0.1% (w / w) to about 6% (w / w),Attorney Docket No.63230-732.601 about 0.1% (w / w) to about 5% (w / w), about 0.1% (w / w) to about 4% (w / w), about 0.1% (w / w) to about 3% (w / w), about 0.1% (w / w) to about 2% (w / w), about 0.1% (w / w) to about 1% (w / w), about 0.2% (w / w) to about 10% (w / w), about 0.2% (w / w) to about 9% (w / w), about 0.2% (w / w) to about 8% (w / w), about 0.2% (w / w) to about 7% (w / w), about 0.2% (w / w) to about 6% (w / w), about 0.2% (w / w) to about 5% (w / w), about 0.2% (w / w) to about 4% (w / w), about 0.2% (w / w) to about 3% (w / w), about 0.2% (w / w) to about 2% (w / w), about 0.2% (w / w) to about 1% (w / w), about 0.5% (w / w) to about 10% (w / w), about 0.5% (w / w) to about 9% (w / w), about 0.5% (w / w) to about 8% (w / w), about 0.5% (w / w) to about 7% (w / w), about 0.5% (w / w) to about 6% (w / w), about 0.5% (w / w) to about 5% (w / w), about 0.5% (w / w) to about 4% (w / w), about 0.5% (w / w) to about 3% (w / w), about 0.5% (w / w) to about 2% (w / w), about 0.5% (w / w) to about 1% (w / w), about 1% (w / w) to about 10% (w / w), about 1% (w / w) to about 9% (w / w), about 1% (w / w) to about 8% (w / w), about 1% (w / w) to about 7% (w / w), about 1% (w / w) to about 6% (w / w), about 1% (w / w) to about 5% (w / w), about 1% (w / w) to about 4% (w / w), about 1% (w / w) to about 3% (w / w), about 1% (w / w) to about 2% (w / w), about 2% (w / w) to about 10% (w / w), about 2% (w / w) to about 9% (w / w), about 2% (w / w) to about 8% (w / w), about 2% (w / w) to about 7% (w / w), about 2% (w / w) to about 6% (w / w), about 2% (w / w) to about 5% (w / w), about 2% (w / w) to about 4% (w / w), about 2% (w / w) to about 3% (w / w), about 3% (w / w) to about 10% (w / w), about 3% (w / w) to about 9% (w / w), about 3% (w / w) to about 8% (w / w), about 3% (w / w) to about 7% (w / w), about 3% (w / w) to about 6% (w / w), about 3% (w / w) to about 5% (w / w), about 3% (w / w) to about 4% (w / w), about 4% (w / w) to about 10% (w / w), about 4% (w / w) to about 9% (w / w), about 4% (w / w) to about 8% (w / w), about 4% (w / w) to about 7% (w / w), about 4% (w / w) to about 6% (w / w), about 4% (w / w) to about 5% (w / w), about 5% (w / w) to about 10% (w / w), about 5% (w / w) to about 9% (w / w), about 5% (w / w) to about 8% (w / w), about 5% (w / w) to about 7% (w / w), or about 5% (w / w) to about 6% (w / w) of a total weight of the composition.

[0147] In some embodiments, the concentration (%w / w) of each of the at least one antioxidant in the composition is about 0.001%, about 0.005%, about 0.01%, about 0.02%, about 0.04%, about 0.06%, about 0.08%, about 0.1%, about 0.5%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, or any values therebetween. In some embodiments, the concentration (%w / w) of each of the at least one antioxidant in the composition is about 0.01% to about 5%, about 0.02% to about 4.5%, about 0.04%% to about 4%, about 0.06% to about 3.5%, about 0.08% to about 3%, about 0.1% to about 2.5%, about 0.5% to about 2%, or about 1% to about 5%.

[0148] In some embodiments, the composition comprises carnosine at about 0.005% to about 5% by weight, about 0.1% to about 5% by weight, about 0.5% to about 5% by weight, about 1% toAttorney Docket No.63230-732.601 about 5% by weight, about 2% to about 5% by weight, about 1% to about 2% by weight. In some instances, the carnosine is present in the composition at about 0.005%, about 0.05%, about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.8%, about 1.9%, about 2%, or about 5% by weight of the composition. pH Modifier

[0149] In one aspect, the composition for removing metals from hair as described herein further comprises at least one pH modifier. In some instances, as described herein, pH modifier, or pH adjuster, refers to an agent or a molecule that helps adjusting the pH of the composition. In some instances, the pH modifier can maintain stability of the composition or act as a preservative. In some instances, primary and secondary metals are more soluble in acidic solutions. Therefore, in some instances, the at least one chelating agent is provided in compositions having an acidic pH. However, in some instances, the at least one chelating agent disclosed herein is more effective under alkaline conditions. Accordingly, the present disclosure provides a hair demineralizer composition that is effective at alkaline pH conditions. In some embodiments, the hair demineralizer composition comprises at least one pH modifier to provide optimized pH conditions. In some embodiments, the hair demineralizer composition is effective under mild alkaline conditions, at pH from about 6 to about 9, or about 7 to about 8.

[0150] In some instances, the composition has a pH of about 5 to about 9. In some embodiments, the composition has a pH of about 7 to about 8. In some instances, the composition has a pH of about 5 to about 6.

[0151] In some embodiments, the composition described herein further comprises at least one pH modifier. In some embodiments, the at least one pH modifier may be present to modulate the pH of the composition. In some embodiments, the at least one pH modifier may have a pKa. In some instances, the at least one pH modifier may comprise a pKa of about 3.0 to about 10.0, about 3.0 to about 9.0, about 3.0 to about 8.0, about 3.0 to about 7.0, about 3.0 to about 6.0, about 3.0 to about 5.0, about 4.0 to about 9.0, about 4.0 to about 8.0, about 4.0 to about 7.0, about 4.0 to about 6.0, about 5.0 to about 9.0, about 5.0 to about 8.0, about 5.0 to about 7.0, about 6.0 to about 9.0, about 6.0 to about 8.0, about 6.0 to about 7.0, about 7.0 to about 9.0, about 7.0 to about 8.0, or about 8.0 to about 9.0. In some embodiments, the at least one pH modifier has a pKa of about 4.0 to about 10.0, about 4.0 to about 9.0, about 4.0 to about 8.0, about 4.0 to about 7.0, or about 4.0 to about 6.0.

[0152] In some embodiments, the at least one pH modifier does not react with the at least one chelating agent. In some embodiments, the at least one pH modifier comprises lactic acid, citricAttorney Docket No.63230-732.601 acid, malic acid, gluconic acid, glucuronic acid, glycolic acid, tartaric acid, azelaic acid, acetic acid, sodium hydroxide, triethanolamine, L-arginine, or a combination thereof. In some embodiments, the at least one pH modifier further comprises potassium hydroxide, sodium hydroxide, or both.

[0153] In some embodiments, the total concentration (%w / w) of the at least one pH modifier in the composition is about 0.01% to about 5%, about 0.05% to about 5%, about 0.1% to about 5%, about 0.5% to about 5%, about 1% to about 5%, about 2% to about 5%, about 3% to about 5%, or about 4% to about 5%. In some embodiments, the total concentration (%w / w) of the at least one pH modifier in the composition is about 0.01%, about 0.05%, about 0.1%, about 0.15%, about 0.2%, about 0.25%, about 0.3%, about 0.35%, about 0.4%, about 0.45%, about 0.5%, about 0.55%, about 0.6%, about 0.65%, about 0.7%, about 0.75%, about 0.8%, about 0.85%, about 0.9%, about 0.95%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, or any values therebetween. In some embodiments, the total concentration (%w / w) of the at least one pH modifier in the composition is at least about 0.01%, at least about 0.05%, at least about 0.1%, at least about 0.5%, at least about 1%, at least about 2%, at least about 3%, at least about 4%, or at least about 5%. In some embodiments, the total concentration (%w / w) of the at least one pH modifiers in the composition is at most about 0.01%, at most about 0.05%, at most about 0.1%, at most about 0.5%, at most about 1%, at most about 2%, at most about 3%, at most about 4%, or at most about 5%.

[0154] In some embodiments, the total concentration (%w / w) of the at least one pH modifier in the composition is about 0.1% (w / w) to about 1% (w / w) of a total weight of the composition.

[0155] In some embodiments, the concentration (%w / w) of each of the at least one pH modifier in the composition is about 0.01%, about 0.05%, about 0.1%, about 0.15%, about 0.2%, about 0.25%, about 0.3%, about 0.35%, about 0.4%, about 0.45%, about 0.5%, about 0.55%, about 0.6%, about 0.65%, about 0.7%, about 0.75%, about 0.8%, about 0.85%, about 0.9%, about 0.95%, about 1%, about 1.5%, about 2%, about 2.5%, about 3%, about 3.5%, about 4%, about 4.5%, about 5%, or any values therebetween. In some embodiments, the concentration (%w / w) of each of the at least one pH modifier in the composition is about 0.01% to about 5%, about 0.05% to about 4.5%, about 0.1% to about 4%, about 0.15% to about 3.5%, about 0.2% to about 3%, about 0.25% to about 2.5%, about 0.3% to about 2%, about 0.35% to about 1.5%, about 0.4% to about 1%, about 0.45% to about 0.95%, about 0.5% to about 0.9%, about 0.55% to about 0.85%, about 0.6% to about 0.8%, about 0.6% to about 0.75%, or about 0.65% to about 0.7%. In some embodiments, the concentration (%w / w) of each of the at least one pH modifier in the composition is at least about 0.01%, at least about 0.05%, at least about 0.1%, at least about 0.15%, at least about 0.2%, at least about 0.25%, at least about 0.3%, at least about 0.35%, at least about 0.4%, at least about 0.45%, atAttorney Docket No.63230-732.601 least about 0.5%, at least about 0.55%, at least about 0.6%, at least about 0.65%, at least about 0.7%, at least about 0.75%, at least about 0.8%, at least about 0.85%, at least about 0.9%, at least about 0.95%, at least about 1%, at least about 1.5%, at least about 2%, at least about 2.5%, at least about 3%, at least about 3.5%, at least about 4%, at least about 4.5%, or at least about 5%. In some embodiments, the concentration (%w / w) of each of the at least one pH modifiers in the composition is at most about 0.01%, at most about 0.05%, at most about 0.1%, at most about 0.15%, at most about 0.2%, at most about 0.25%, at most about 0.3%, at most about 0.35%, at most about 0.4%, at most about 0.45%, at most about 0.5%, at most about 0.55%, at most about 0.6%, at most about 0.65%, at most about 0.7%, at most about 0.75%, at most about 0.8%, at most about 0.85%, at most about 0.9%, at most about 0.95%, at most about 1%, at most about 1.5%, at most about 2%, at most about 2.5%, at most about 3%, at most about 3.5%, at most about 4%, at most about 4.5%, or at most about 5%.

[0156] In some instances, the at least one pH modifier comprises lactic acid. In some embodiments, the composition comprises lactic acid present in the composition at about 0% to about 2% by weight, about 0.1% to about 2% by weight, about 0.5% to about 2% by weight, about 1% to about 2% by weight, about 0.05% to about 1% by weight, about 0.1% to about 1% by weight, or about 0.5% to about 1% by weight. In some instances, the lactic acid is present in the composition at about 0.1%, about 0.2%, about 0.3%, about 0.4%, about 0.5%, about 0.6%, about 0.7%, about 0.8%, about 0.9%, about 1%, about 1.1%, about 1.2%, about 1.3%, about 1.4%, about 1.5%, about 1.6%, about 1.8%, about 1.9%, about 2%, or about 5% by weight of the composition. In some instances, the lactic acid is present in the composition at least about 0.1%, at least about 0.2%, at least about 0.3%, at least about 0.4%, at least about 0.5%, at least about 0.6%, at least about 0.7%, at least about 0.8%, at least about 0.9%, at least about 1%, at least about 1.1%, at least about 1.2%, at least about 1.3%, at least about 1.4%, at least about 1.5%, at least about 1.6%, at least about 1.8%, at least about 1.9%, at least about 2%, or at least about 5% by weight of the composition. In some instances, the lactic acid is present in the composition at most about 0.1%, at most about 0.2%, at most about 0.3%, at most about 0.4%, at most about 0.5%, at most about 0.6%, at most about 0.7%, at most about 0.8%, at most about 0.9%, at most about 1%, at most about 1.1%, at most about 1.2%, at most about 1.3%, at most about 1.4%, at most about 1.5%, at most about 1.6%, at most about 1.8%, at most about 1.9%, at most about 2%, or at most about 5% by weight of the composition. Solvent

[0157] In some embodiments, the composition for removing metals from hair as described herein further comprises at least one solvent. In some instances, as described herein, solvent refers to anAttorney Docket No.63230-732.601 agent or a molecule that dissolves a solute in a solution. In some instances, the at least one solvent comprises a polar aprotic solvent, a polar protic solvent, a halocarbon solvent, or a combination thereof. In some embodiments, the at least one solvent comprises an aqueous solvent. In some embodiments, the at least one solvent comprises a polar solvent, a nonpolar solvent, or a combination thereof. In some embodiments, the at least one solvent comprises water, alcohol, glycol, ester, ether, ketone, organic acid, halogenated solvent, or a combination thereof. In some embodiments, the at least one solvent comprises water, dimethyl isosorbide, triethyl citrate, phenethyl benzoate, dicaprylyl maleate, dilinoleic acid / propanediol copolymer, lower alcohols containing from 1 to 6 carbon atoms, such as ethanol; polyols such as glycerin, glycols such as butylene glycol, isoprene glycol, propylene glycol, dipropylene glycol, propanediol, isopentyldiol, polyethylene glycols such as PEG-8, sorbitol, sugars such as glucose, fructose, maltose, lactose, sucrose, or a combination thereof.

[0158] In some instances, the polar aprotic solvent comprises dimethyl isosorbide, 1-methyl-2- pyrrolidone, 1-ethylpyrrolidin-2-one, N,N-dimethylacetamide, N-N-dimethylformamide (DMF), or a combination thereof. In some instances, the polar protic solvent comprises water, alcohol, glycol, or a combination thereof.

[0159] In some embodiments, the alcohol comprises methanol, ethanol, propanol, isopropanol, 1- butanol, 2-butanol, isobutanol, 1,4-butanediol, benzyl alcohol, or a combination thereof. In some instances, the alcohol comprises methanol, ethanol, propanol, isopropanol, isobutanol, triethyl citrate, or pantothenyl alcohol. In some embodiments, the alcohol comprises methanol, ethanol, propanol, isopropanol, isobutanol, triethyl citrate, or pantothenyl alcohol.

[0160] In some instances, the glycol comprises ethylene glycol, propane-1,2-glycol, propane-1,3- glycol, glycerol, or a combination thereof. In some instances, the glycol comprises ethylene glycol, propane-1,2-glycol, propane-1,3-glycol, or a combination thereof. In some embodiments, the glycol comprises glycerol, ethylene glycol, or a combination thereof.

[0161] In some embodiments, the ester comprises t-butyl acetate, butyl acetate, ethylene carbonate, propyl acetate, dimethyl carbonate, ethyl acetate, ethyl propionate, methyl acetate, ethyl format, or a combination thereof. In some embodiments, the ether comprises diethylene glycol, anisole, diphenyl ether, dibutyl ether, t-butyl ethyl ether, t-amyl methyl ether, dimethyl isosorbide, ethoxybenzene, or a combination thereof. In some embodiments, the ketone comprises acetone, methylethyl ketone, cyclohexanone, cyclopentanone, or a combination thereof. In some embodiments, the organic acid comprises propionic acid, acetic anhydride, acetic acid, trimethyl citrate, triethyl citrate, or a combination thereof. In some embodiments, the halogenated solventAttorney Docket No.63230-732.601 comprises chlorobenzene, trichloroacetonitrile, chloroacetic acid, chlorotrifluoropropene, or a combination thereof. In some instances, the halocarbon solvent comprises chlorotrifluoropropene.

[0162] In some embodiments, the at least one solvent comprises water and an alcohol. In some instances, the at least one solvent comprises water, methanol, or a combination thereof. In some instances, the at least one solvent comprises water, ethanol, or a combination thereof. In some embodiments, the at least one solvent comprises water, an alcohol, an ether, or a combination thereof. In some embodiments, the at least one solvent comprises water, an alcohol, an ether, an organic acid, or a combination thereof. In some embodiments, the at least one solvent comprises water, an alcohol, an ether, an organic acid, a halogenated solvent, or a combination thereof. In some embodiments, the at least one solvent comprises water, alcohols, dimethyl isosorbide, chlorotrifluoropropene, glycols, triethyl citrate, or a combination thereof. In some embodiments, the at least one solvent comprises water, alcohol, glycol, or a combination thereof.

[0163] In some embodiments, the total concentration (%w / w) of the at least one solvent in the composition is about 5% to about 90%, about 10% to about 90%, about 15% to about 90%, about 20% to about 90%, about 25% to about 90%, about 30% to about 90%, about 35% to about 90%, about 40% to about 90%, about 45% to about 90%, about 50% to about 90%, about 55% to about 90%, about 60% to about 90%, about 65% to about 90%, about 70% to about 90%, or about 75% to about 90%. In some embodiments, the concentration of each of the at least one solvent in the composition is about 5%, about 10%, about 15%, about 20%, about 25%, about 30%, about 35%, about 40%, about 45%, about 50%, about 55%, about 60%, about 65%, about 70%, about 75%, about 80%, about 85%, about 90%, or any values therebetween. In some embodiments, the concentration of each of the at least one solvent in the composition is at least about 5%, at least about 10%, at least about 15%, at least about 20%, at least about 25%, at least about 30%, at least about 35%, at least about 40%, at least about 45%, at least about 50%, at least about 55%, at least about 60%, at least about 65%, at least about 70%, at least about 75%, at least about 80%, at least about 85%, or at least about 90%. In some embodiments, the concentration of each of the at least one solvent in the composition is at most about 5%, at most about 10%, at most about 15%, at most about 20%, at most about 25%, at most about 30%, at most about 35%, at most about 40%, at most about 45%, at most about 50%, at most about 55%, at most about 60%, at most about 65%, at most about 70%, at most about 75%, at most about 80%, at most about 85%, or at most about 90%. In some embodiments, the concentration of the at least one solvent in the composition is about 5% and about 90%, about 10% and about 85%, about 15% and about 80%, about 20% and about 75%, about 25% and about 70%, about 20% and about 65%, about 25% and about 60%, about 30% and about 55%, about 35% and about 50%, or about 40% and about 45%.Attorney Docket No.63230-732.601

[0164] In some instances, the at least one solvent comprises water. In some embodiments, the composition comprises water present in the composition at about 80% to about 95% by weight, about 80% to about 85%, about 85% to about 95% by weight, about 90% to about 95% by weight, or about 85% to about 90% by weight. In some instances, the water is present in the composition at about 80%, about 81%, about 82%, about 83%, about 84%, about 85%, about 86%, about 87%, about 88%, about 89%, about 90%, about 91%, about 92%, about 93%, about 94%, or about 95% by weight of the composition. In some instances, the water is present in the composition at least about 80%, at least about 81%, at least about 82%, at least about 83%, at least about 84%, at least about 85%, at least about 86%, at least about 87%, at least about 88%, at least about 89%, at least about 90%, at least about 91%, at least about 92%, at least about 93%, at least about 94%, or at least about 95% by weight of the composition. In some instances, the water is present in the composition at most about 80%, at most about 81%, at most about 82%, at most about 83%, at most about 84%, at most about 85%, at most about 86%, at most about 87%, at most about 88%, at most about 89%, at most about 90%, at most about 91%, at most about 92%, at most about 93%, at most about 94%, or at most about 95% by weight of the composition. Excipient

[0165] In some instances, the composition for removing metals hair as described herein further comprises at least one excipient. In some instances, the composition for removing metals hair as described herein further comprises at least one cosmetically or dermatologically acceptable excipient. In some embodiments, the at least one dermatologically acceptable excipient comprises a detoxifying agent, a suspending agent, a perfume, a preservative, or a combination thereof. In some embodiments, the at least one cosmetically or dermatologically acceptable excipient comprises a perfume, a preservative, or a combination thereof. Non-limiting example of the cosmetically or dermatologically acceptable excipient includes, but is not limited to, preservatives, co-solvents, sunscreen agents, vitamins, dyes, hair coloring agents, proteins, amino acids, organic polymers, natural extracts such as plant extracts, humectants, fragrances, perfumes, oils, emollients, lubricants, butters, penetrants, viscosity modifiers, polymers, e.g., naturally derived polymer, resins, hair fixatives, silicones, film formers, detergents, opacifying agents, volatiles, liquid vehicles, carriers, salts, pH adjusting agents, e.g., buffers, neutralizing agents, hair conditioning agents, anti-static agents, anti-frizz agents, anti-dandruff agents, aliphatic alcohol, or a combination thereof.

[0166] In some instances, the detoxifying agent comprises a clay, an acid, or a combination thereof. In some embodiments, the detoxifying agent comprises charcoal, bentonite clay, diatomite clay, kaolin clay, salicylic acid, ascorbic acid, glycolic acid, or a combination thereof.Attorney Docket No.63230-732.601

[0167] In some instances, the detoxifying agent is present at a concentration (% w / w) of about 0.1% (w / w) to about 1% (w / w) of a total weight of the composition. In some instances, the detoxifying agent is present at a concentration (% w / w) of about 0.1% (w / w) to about 1% (w / w), about 0.1% (w / w) to about 0.9% (w / w), about 0.1% (w / w) to about 0.8% (w / w), about 0.1% (w / w) to about 0.7% (w / w), about 0.1% (w / w) to about 0.6% (w / w), about 0.1% (w / w) to about 0.5% (w / w), about 0.1% (w / w) to about 0.4% (w / w), about 0.1% (w / w) to about 0.3% (w / w), about 0.1% (w / w) to about 0.2% (w / w), about 0.2% (w / w) to about 1% (w / w), about 0.2% (w / w) to about 0.9% (w / w), about 0.2% (w / w) to about 0.8% (w / w), about 0.2% (w / w) to about 0.7% (w / w), about 0.2% (w / w) to about 0.6% (w / w), about 0.2% (w / w) to about 0.5% (w / w), about 0.2% (w / w) to about 0.4% (w / w), about 0.2% (w / w) to about 0.3% (w / w), about 0.3% (w / w) to about 1% (w / w), about 0.3% (w / w) to about 0.9% (w / w), about 0.3% (w / w) to about 0.8% (w / w), about 0.3% (w / w) to about 0.7% (w / w), about 0.3% (w / w) to about 0.6% (w / w), about 0.3% (w / w) to about 0.5% (w / w), about 0.3% (w / w) to about 0.4% (w / w), about 0.4% (w / w) to about 1% (w / w), about 0.4% (w / w) to about 0.9% (w / w), about 0.4% (w / w) to about 0.8% (w / w), about 0.4% (w / w) to about 0.7% (w / w), about 0.4% (w / w) to about 0.6% (w / w), about 0.4% (w / w) to about 0.5% (w / w), about 0.5% (w / w) to about 1% (w / w), about 0.5% (w / w) to about 0.9% (w / w), about 0.5% (w / w) to about 0.8% (w / w), about 0.5% (w / w) to about 0.7% (w / w), about 0.5% (w / w) to about 0.6% (w / w), about 0.6% (w / w) to about 1% (w / w), about 0.6% (w / w) to about 0.9% (w / w), about 0.6% (w / w) to about 0.8% (w / w), or about 0.6% (w / w) to about 0.7% (w / w) of a total weight of the composition.

[0168] In some instances, the suspending agent comprises an anionic polymer, nonionic polymer, or a combination thereof. In some instances, the suspending agent comprises carbomer, methyl cellulose, ethyl cellulose, nitrocellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder, polyvinylpyrrolidone, polyvinyl alcohol, guar gum, hydroxypropyl guar gum, arabia gum, galactan, carob gum, pectin, agar, quince seed (Cydonia oblonga Mill), starch (rice, corn, potato, wheat), algae colloid (algae extract), dextran, succinoglucan, pulleran, carboxymethyl starch, methylhydroxypropyl starch, sodium alginate, alginic acid propylene glycol ester, sodium polyacrylate, polyethylacrylate, polyacrylamide, polyethyleneimine, bentonite, aluminum magnesium silicate, laponite, hectonite, anhydrous silicic acid, or a combination thereof.

[0169] In some instances, the suspending agent is present at a concentration (% w / w) of about 0.1% (w / w) to about 1% (w / w) of a total weight of the composition.

[0170] In some instances, the composition described herein further comprises a thickening agent. In some instances, the thickening agent increases a viscosity of the composition when dispersed or dissolved in water or a water-soluble solvent. In some instances, the thickening agent comprises aAttorney Docket No.63230-732.601 carboxylic acid polymer, a crosslinked polyacrylate polymer, a polyacrylamide polymer, a polysaccharide, a gum, or a combination thereof.

[0171] In some embodiments, the thickening agent comprises xanthan gum, guar gum, biosaccharide gum, cellulose, gum acacia, sclerotium gum, agarose, pectin, gellan gum, hyaluronic acid, or a combination thereof. In some embodiments, the thickening agent comprises polymeric thickening agents selected from the group consisting of ammonium polyacryloyldimethyl taurate, ammonium acryloyldimethyltaurate / vinylpyrrolidone copolymer, sodium polyacrylate, acrylate copolymer, polyacrylamide, carbomer, acrylate / C10-30 alkyl acrylate crosspolymer, acrylamide / sodium acryloyldimethyltaurate copolymer, or a combination thereof.

[0172] In some instances, the carboxylic acid polymer comprises a carbomer, acrylic acid, substituted acrylic acid, or a salt or ester thereof, each monomer of the carboxylic acid polymer is connected via a double bond.

[0173] In some instances, the polysaccharide comprises an alkyl-substituted cellulose comprising methylcellulose, a hydroxyethylcellulose, a carboxymethylcellulose, or an acylated derivative thereof, or a combination thereof.

[0174] In some instances, the gum comprises acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hectorite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, biosaccharide gum, or a combination thereof.

[0175] In some embodiments, the preservative comprises gluconolactone, benzyl alcohol, calcium gluconate, sodium benzoate, phenoxyethanol, potassium sorbate, ethylhexylglycerin, caprylyl glycol, caprylhydroxamic acid, or a combination thereof. In some embodiments, the preservative comprises benzoic acid, butyl paraben, diazolidinyl urea, DMDM hydantoin, ethyl paraben, imidazolidinyl urea, iodopropynyl butylcarbamate, isobutyl paraben, methyl paraben, methylchloroisothiazolinone, methylisothiazolinone, phenoxyethanol, propyl paraben, sodium benzoate, potassium sorbate, ethylhexylglycerin, gluconolactone, or a combination thereof. Non- limiting example of a preservative includes, but is not limited to, benzoic acid, butyl paraben, diazolidinyl urea, DMDM hydantoin, ethyl paraben, imidazolidinyl urea, iodopropynyl butylcarbamate, isobutyl paraben, methyl paraben, methylchloroisothiazolinone, methylisothiazolinone, phenoxyethanol, propyl paraben, sodium benzoate, potassium sorbate, ethylhexylglycerin, gluconolactone, or a combination thereof.Attorney Docket No.63230-732.601

[0176] In some embodiments, the naturally derived polymer comprises xanthan gum, pullulan, algin, tetragonoloba (guar) gum, sclerotium gum, acacia Senegal gum, cellulose, cellulose gum, carboxymethylcellulose, carbomer, hydroxypropyl starch phosphate, guar hydroxypropyltrimonium chloride, carboxymethyl hydroxyethyl cellulose, carboxymethyl hydroxypropyl guar, cellulose, ethyl cellulose, hydroxybutyl methylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, lauryl polyglucose, and a combination thereof.

[0177] In some instances, the anti-static agent comprises quaternary ammonium compounds, behentrimonium chloride, behentrimonium methosulfate, cetrimonium chloride, cetrimonium methosulfate, benzalkonium chloride, benzethonium chloride, cinnamidopropyltrimonium chloride, cocotrimonium chloride, dicetyldimonium chloride, dicocodimonium chloride, laurtrimonium chloride, stearamidopropyl dimethylamine, steartrimonium chloride, stearalkonium chloride, tricetyldimonium chloride, PCA ethyl cocoyl arginate, C10-40 isoalkylamidopropylethyldimonium ethosulfate, dipalmitoylethyl hydroxyethylmonium methosulfate, shea butter, amidopropyltrimonium chloride, or a combination thereof.

[0178] In some instances, the humectant comprises 1,2,6 hexanetriol, dipropylene glycol, glycerin, butylene glycol, caprylyl glycol, pentylene glycol, isopentyldiol, hexylene glycol, panthenol, phytantriol, propylene glycol, propanediol, sodium PCA, sorbitol, triethylene glycol, polyglyceryl sorbitol, glucose, fructose, mannitol, xylitol, inositol, trehalose, polydextrose, potassium PCA, hydrogenated honey, hyaluronic acid, inositol, erythritol, capryl glycol, acetamidoethoxyethanol, or a combination thereof.

[0179] In some instances, the amino acid comprises L-cysteine. In some instances, the protein comprises cocodimonium hydroxypropyl hydrolyzed casein, cocodimonium hydroxypropyl hydrolyzed collagen, cocodimonium hydroxypropyl hydrolyzed hair keratin, cocodimonium hydroxypropyl hydrolyzed keratin, cocodimonium hydroxypropyl hydrolyzed rice protein, cocodimonium hydroxypropyl hydrolyzed silk, cocodimonium hydroxypropyl hydrolyzed soy protein, cocodimonium hydroxypropyl hydrolyzed wheat protein, cocodimonium hydroxypropyl silk amino acids, cocoyl hydrolyzed collagen, cocoyl hydrolyzed keratin, hydrolyzed keratin, hydrolyzed oat flour, hydrolyzed silk, hydrolyzed silk protein, hydrolyzed soy protein, hydrolyzed wheat protein, hydrolyzed quinoa, hydrolyzed elastin, hydrolyzed collagen, keratin, potassium cocoyl hydrolyzed collagen, or a combination thereof.

[0180] In some instances, the silicone comprises amodimethicone, dimethicone cyclomethicone, cyclopentasiloxane, dimethicone, dimethicone copolyol, dimethiconol, hydrolyzed wheat protein hydroxypropyl polysiloxane, trimethylsilylamodimethicone, or a combination thereof.Attorney Docket No.63230-732.601

[0181] In some instances, the vitamin comprises retinol, retinyl palmitate, ascorbic acid, tocopherol, tocopherol acetate, or a combination thereof.

[0182] In some instances, the natural extract comprises Aloe barbadensis leaf extract, Yucca schidigera leaf extract, Yucca schidigera root extract, Camellia sinensis leaf extract, Equisetum arvense leaf extract, Hamamelis virginiana leaf extract, Macrocystis pyrifera kelp extract, or a combination thereof.

[0183] In some instances, the emollient comprises isopropyl lauroyl sarcosinate, phenethyl benzoate, C12-15alkyl benzoate, caprylic / capric triglyceride, cetyl octanoate, octyldodecanol, dilinoleic acid / propanediol copolymer, isoamyl laurate, oleic acid, isohexadecane, squalane, isopropyl palmitate, polycitronellol, diheptyl succinate, capryloyl glycerin / sebacic acid copolymer, PPG-3 benzyl ether ethylhexanoate, hydrogenated vegetable oil, triheptanoin, diisopropyl sebacate, diisopropyl adipate, propylene glycol dibenzoate, propoxytetramethyl piperidinyl dimethicone, castor oil / IPDI copolymer, butylene glycol cocoate, butylene glycol dicaprylate / dicaprate (dispersant), propylene glycol dicaprylate / dicaprate, triolein (algae oil), propylene glycol dicaprylate / dicaprate, phytosteryl / octyldodecyl lauroyl glutamate, C10-18 triglycerides, isostearyl alcohol, diisostearyl malate, isoamyl laurate, isoamyl cocoate, hemisqualane, polycitronellol acetate, ethyl macadamiate, coco-caprylate / caprate, coconut alkanes, C9-12 alkane, C13-15 alkane, C13-16 isoalkane, neopentyl glycol diheptanoate, hydrogenated ethylhexyl olivate, hydrogenated olive oil unsaponifiables, undecane, tridecane, isododecane, caprylyl caprylate / caprate, cetyl stearate, cetearyl stearate, decyl oleate, glyceryl stearate, glyceryl adipate, glyceryl arachidate, glyceryl arachidonate, glyceryl behenate, glyceryl caprate, glyceryl caprylate, glyceryl caprylate / caprate, glyceryl citrate / lactate / linoleate / oleate, glyceryl cocoate, glyceryl diarachidate, glyceryl dibehenate, glyceryl dierucate, glyceryl dihydroxystearate, glyceryl diisopalmitate, glyceryl diisostearate, glyceryl dilaurate, glyceryl dilinoleate, glyceryl dimyristate, glyceryl dioleate, glyceryl dipalmitate, glyceryl dipalmitoleate, glyceryl diricinoleate, glyceryl distearate, glyceryl erucate, glycol stearate, isocetyl stearate, isopropyl myristate, isopropyl palmitate, isopropyl stearate, isostearyl stearate, octyl palmitate, octyl stearate, propylene glycol dicaprylate / dicaprate, sorbitan benzoate, sorbitan caprylate, sorbitan isostearate, sorbitan laurate, sorbitan tristearate, stearyl stearate, tocopheryl linoleate, olive oil, avocado oil, coconut oil, sunflower oil, jojoba oil, argan oil, castor oil, almond oil, sesamum indicum (sesame) seed oil, prunus areniaca (apricot) kernel oil, crambe abyssinica seed oil, oryza sativa (rice) bran oil, vitis vinifera (grape) seed oil, Passiflora edulis seed oil, meadowfoam seed oil, butyrospermum parkii (shea) butter, shorea robusta seed butter, murumuru butter, or a combination thereof.Attorney Docket No.63230-732.601

[0184] In some instances, the buffer comprises ascorbic acid, citric acid, lactic acid, glycolic acid, tartaric acid, malic acid, L-arginine, potassium hydroxide, sodium hydroxide, triethanolamine, sodium bicarbonate, or a combination thereof.

[0185] In some instances, the aliphatic alcohol comprises lauric acid, palmitic acid, stearic acid, arachidic alcohol, behenyl alcohol, cetearyl alcohol, cetyl alcohol, isocetyl alcohol, isostearyl alcohol, lauryl alcohol, myristyl alcohol, stearyl alcohol, C30-50alcohols, lanolin alcohol, or a combination thereof.

[0186] In some instances, the perfume comprises fragrance (parfum), limonene, hydroxycitronellol, benzyl salicylate, hexyl cinnamal, or a combination thereof.

[0187] In some embodiments, the total concentration (%w / w) of the at least one excipient in the composition is about 0.001%, about 0.005%, about 0.01%, about 0.05%, about 0.1%, about 0.5%, about 1%, about 2%, about 3%, about 4%, about 5%, about 6%, about 7%, about 8%, about 9%, about 10%, or any values therebetween. In some instances, the total concentration (%w / w) of the at least one excipient in the composition is at least about 0.001%, at least about 0.005%, at least about 0.01%, at least about 0.05%, at least about 0.1%, at least about 0.5%, at least about 1%, at least about 2%, at least about 3%, at least about 4%, at least about 5%, at least about 6%, at least about 7%, at least about 8%, at least about 9%, or at least about 10%. In some instances, the total concentration (%w / w) of the at least one excipient in the composition is at most about 0.001%, at most about 0.005%, at most about 0.01%, at most about 0.05%, at most about 0.1%, at most about 0.5%, at most about 1%, at most about 2%, at most about 3%, at most about 4%, at most about 5%, at most about 6%, at most about 7%, at most about 8%, at most about 9%, or at most about 10%. In some instances, the total concentration (%w / w) of the at least one excipient in the composition is about 0.001% to about 10%, about 0.005% to about 10%, about 0.01% to about 10%, about 0.05% to about 10%, about 0.1% to about 10%, about 0.5% to about 10%, about 1% to about 10%, about 2% to about 10%, about 3% to about 10%, about 4% to about 10%, about 5% to about 10%, about 6% to about 10%, about 7% to about 10%, about 8% to about 10%, or about 9% to about 10%.

[0188] In some embodiments, the concentration (%w / w) of each of the at least one excipient in the composition is about 0.001%, about 0.005%, about 0.01%, about 0.05%, about 0.1%, about 0.5%, about 1%, about 2%, about 3%, about 4%, about 5%, about 6%, about 7%, about 8%, about 9%, about 10%, or any values therebetween. In some embodiments, the concentration (%w / w) of each of the at least one excipient in the composition is at least about 0.001%, at least about 0.005%, at least about 0.01%, at least about 0.05%, at least about 0.1%, at least about 0.5%, at least about 1%, at least about 2%, at least about 3%, at least about 4%, at least about 5%, at least about 6%, at least about 7%, at least about 8%, at least about 9%, or at least about 10%. In some embodiments,Attorney Docket No.63230-732.601 the concentration (%w / w) of each of the at least one excipient in the composition is at most about 0.001%, at most about 0.005%, at most about 0.01%, at most about 0.05%, at most about 0.1%, at most about 0.5%, at most about 1%, at most about 2%, at most about 3%, at most about 4%, at most about 5%, at most about 6%, at most about 7%, at most about 8%, at most about 9%, or at most about 10%. In some embodiments, the concentration (%w / w) of each of the at least one excipient in the composition is about 0.001% to about 10%, about 0.005% to about 10%, about 0.01% to about 10%, about 0.05% to about 10%, about 0.1% to about 10%, about 0.5% to about 10%, about 1% to about 10%, about 2% to about 10%, about 3% to about 10%, about 4% to about 10%, about 5% to about 10%, about 6% to about 10%, about 7% to about 10%, about 8% to about 10%, or about 9% to about 10%. A. Formats of the Composition

[0189] In one aspect, the composition to remove metals from hair as described herein can be formulated as a foam, a cleanser, a conditioner, an emulsion, a gel, a paste, an aerosol, or a powder, depending on additional agents and method of processing. Foam

[0190] In some instances, the composition described herein is formulated as a foam. In some embodiments, the composition to remove metals from hair comprises a chelator composition comprising at least one chelating agent, at least one antioxidant, and at least one anti-redeposition agent, and the composition is formulated as a foam, e.g., a mousse. In some instances, to formulate the composition as a foam, the composition further comprises foam agent. In some instances, the foam agent comprises a surfactant, a copolymer, or a combination thereof. Methods to formulate the composition as a foam is known in the art and can be used for the composition described in the present disclosure.

[0191] In some instances, the surfactant in the composition formulated as a foam is an anionic surfactant, an amphoteric surfactant, a nonionic surfactant, or a combination thereof. In some instances, the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium xylenesulfonate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium 2-sulfolaurate, sodium myreth sulfate, sodium xylenesulfonate, sodium C14-16 olefin sulfonate, sodium C14-16 alpha olefin sulfonate, disodium lauryl sulfosuccinate, sodium methyl cocoyl taurate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, lauroyl sarcosine, cocoyl sarcosine, myristoyl sarcosine, oleoyl sarcosine, myristoyl / stearoyl sarcosine, sodium lauroylAttorney Docket No.63230-732.601 glutamate, sodium cocoyl glutamate, disodium cocoyl glutamate, cocoyl glutamic acid, lauroyl glutamic acid, potassium cocoyl glutamate, potassium lauroyl glutamate, potassium myristoyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, disodium stearoyl glutamate, sodium palmitoyl glutamate, sodium lauroyl lactylate, sodium astrocaryum murumuruate, sodium laurylglucoside hydroxypropylsulfonate, disodium laurylglucoside hydroxypropyl citrate, sodium hydroxypropylsulfonate laurylglucoside crosspolymer, dioctyl sodium sulfosuccinate, or a combination thereof. In some instances, the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauryl betaine, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium dilauramidoglutamide lysine, sodium cocoamphopropionate, lauroamphoacetate, or a combination thereof. In some instances, the nonionic surfactant is decyl glucoside, lauryl glucoside, coco-glucoside, cocoyl methyl glucamide, capryloyl / caproyl methyl glucamide, lauroyl / myristoyl methyl glucamide, cocamidopropylamine oxide, decylamine oxide, or a combination thereof.

[0192] In some instances, the total concentration of the surfactant in the foam is about 0.1% w / w to about 90% w / w, about 0.1% w / w to about 80% w / w, about 0.1% w / w to about 70% w / w, about 0.1% w / w to about 60% w / w, about 0.1% w / w to about 50% w / w, about 0.1% w / w to about 40% w / w, or about 0.1% w / w to about 30% w / w of a total weight of the foam. In some instances, the total concentration of the surfactant in the foam is about 1% w / w to about 30% w / w of the total weight of the foam, about 5% w / w to about 30% w / w of the total weight of the foam, about 10% w / w to about 30% w / w of the total weight of the foam, about 15% w / w to about 30% w / w of the total weight of the foam, about 20% w / w to about 30% w / w of the total weight of the foam, or about 25% w / w to about 30% w / w of the total weight of the foam. In some instances, the total concentration of the surfactant in the foam is about 5% w / w to about 20% w / w of the total weight of the foam, about 10% w / w to about 20% w / w of the total weight of the foam, or about 15% w / w to about 20% w / w of the total weight of the foam.

[0193] In some instances, the copolymer in the composition formulated as a foam comprises a saccharide, a vinylpolymer, or a combination thereof. In some instances, the vinylpolymer comprises vinylpyrrolidone (e.g., polyvinylpyrrolidone (PVP)), vinyl acetate (e.g., polyvinyl acetate (PVAc)), polymethyl methacrylate (PMMA), polystyrene, or a combination thereof. In some instances, the saccharide comprises hyaluronic acid, maltodextrin, pullulan, galactoarabinan, or a combination thereof.

[0194] In some instances, the foam is a closed foam. In some instances, the foam is an open foam. In some instances, the foam is dispensed using a foam dispenser.Attorney Docket No.63230-732.601

[0195] In some instances, the composition described herein has a viscosity of about 1 centipoise (cP) to about 60 cP, about 5 cP to about 60 cP, about 10 cP to about 60 cP, about 15 cP to about 60 cP, about 20 cP to about 60 cP, about 25 cP to about 60 cP, about 30 cP to about 60 cP, about 35 cP to about 60 cP, about 40 cP to about 60 cP, about 45 cP to about 60 cP, about 50 cP to about 60 cP, or about 55 cP to about 60 cP. In some instances, the foam has a viscosity of at least about 1 cP, at least about 5 cP, at least about 10 cP, at least about 15 cP, at least about 20 cP, at least about 25 cP, at least about 30 cP, at least about 35 cP, at least about 40 cP, at least about 45 cP, at least about 50 cP, at least about 55 cP, or at least about 60 cP. In some instances, the foam has a viscosity of at most about 1 cP, at most about 5 cP, at most about 10 cP, at most about 15 cP, at most about 20 cP, at most about 25 cP, at most about 30 cP, at most about 35 cP, at most about 40 cP, at most about 45 cP, at most about 50 cP, at most about 55 cP, or at most about 60 cP.

[0196] In some instances, the foam has a viscosity of about 1 centipoise (cP) to about 60 cP, about 5 cP to about 60 cP, about 10 cP to about 60 cP, about 15 cP to about 60 cP, about 20 cP to about 60 cP, about 25 cP to about 60 cP, about 30 cP to about 60 cP, about 35 cP to about 60 cP, about 40 cP to about 60 cP, about 45 cP to about 60 cP, about 50 cP to about 60 cP, or about 55 cP to about 60 cP. In some instances, the foam has a viscosity of at least about 1 cP, at least about 5 cP, at least about 10 cP, at least about 15 cP, at least about 20 cP, at least about 25 cP, at least about 30 cP, at least about 35 cP, at least about 40 cP, at least about 45 cP, at least about 50 cP, at least about 55 cP, or at least about 60 cP. In some instances, the foam has a viscosity of at most about 1 cP, at most about 5 cP, at most about 10 cP, at most about 15 cP, at most about 20 cP, at most about 25 cP, at most about 30 cP, at most about 35 cP, at most about 40 cP, at most about 45 cP, at most about 50 cP, at most about 55 cP, or at most about 60 cP.

[0197] In some instances, the composition described herein has a lather volume of about 1 cm3to about 10 cm3, about 2 cm3to about 10 cm3, about 3 cm3to about 10 cm3, about 4 cm3to about 10 cm3, about 5 cm3to about 10 cm3, about 6 cm3to about 10 cm3, about 7 cm3to about 10 cm3, about 8 cm3to about 10 cm3, or about 9 cm3to about 10 cm3. In some instances, the composition described herein has a lather volume of about 1 cm3, about 2 cm3, about 3 cm3, about 4 cm3, about 5 cm3, about 6 cm3, about 7 cm3, about 8 cm3, about 9 cm3, or about 10 cm3. In some instances, the composition described herein has a lather volume of at least about 1 cm3, at least about 2 cm3, at least about 3 cm3, at least about 4 cm3, at least about 5 cm3, at least about 6 cm3, at least about 7 cm3, at least about 8 cm3, at least about 9 cm3, or at least about 10 cm3. In some instances, the composition described herein has a lather volume of at most about 1 cm3, at most about 2 cm3, at most about 3 cm3, at most about 4 cm3, at most about 5 cm3, at most about 6 cm3, at most about 7 cm3, at most about 8 cm3, at most about 9 cm3, or at most about 10 cm3.Attorney Docket No.63230-732.601

[0198] In some instances, the foam has a lather volume of about 1 cm3to about 10 cm3, about 2 cm3to about 10 cm3, about 3 cm3to about 10 cm3, about 4 cm3to about 10 cm3, about 5 cm3to about 10 cm3, about 6 cm3to about 10 cm3, about 7 cm3to about 10 cm3, about 8 cm3to about 10 cm3, or about 9 cm3to about 10 cm3. In some instances, the foam has a lather volume of about 1 cm3, about 2 cm3, about 3 cm3, about 4 cm3, about 5 cm3, about 6 cm3, about 7 cm3, about 8 cm3, about 9 cm3, or about 10 cm3. In some instances, the foam has a lather volume of at least about 1 cm3, at least about 2 cm3, at least about 3 cm3, at least about 4 cm3, at least about 5 cm3, at least about 6 cm3, at least about 7 cm3, at least about 8 cm3, at least about 9 cm3, or at least about 10 cm3. In some instances, the foam has a lather volume of at most about 1 cm3, at most about 2 cm3, at most about 3 cm3, at most about 4 cm3, at most about 5 cm3, at most about 6 cm3, at most about 7 cm3, at most about 8 cm3, at most about 9 cm3, or at most about 10 cm3.

[0199] In some instances, the chelator composition in the foam is present at a concentration of about 0.05% w / w to about 30% w / w of a total weight of the foam, about 0.1% w / wo to about 30% w / w of a total weight of the foam, about 1% w / w to about 30% w / w of the total weight of the foam, about 5% w / w to about 30% w / w of the total weight of the foam, about 10% w / w to about 30% w / w of the total weight of the foam, about 15% w / w to about 30% w / w of the total weight of the foam, about 20% w / w to about 30% w / w of the total weight of the foam, or about 25% w / w to about 30% w / w of the total weight of the foam. In some instances, the chelator composition in the foam is present at a concentration of about 5% w / w to about 20% w / w of the total weight of the foam, about 10% w / w to about 20% w / w of the total weight of the foam, or about 15% w / w to about 20% w / w of the total weight of the foam. In some instances, the chelator composition in the foam is present at a concentration of about 0.05% w / w of the total weight of the foam, about 0.1% w / w of the total weight of the foam, about 0.5% w / w of the total weight of the foam, about 1% w / w of the total weight of the foam, about 5% w / w of the total weight of the foam, about 10% w / w of the total weight of the foam, about 15% w / w of the total weight of the foam, about 20% w / w of the total weight of the foam, about 25% w / w of the total weight of the foam, or about 30% w / w of the total weight of the foam. In some instances, the chelator composition in the foam is present at a concentration of at least about 0.05% w / w of the total weight of the foam, at least about 0.1% w / w of the total weight of the foam, at least about 0.5% w / w of the total weight of the foam, at least about 1% w / w of the total weight of the foam, at least about 5% w / w of the total weight of the foam, at least about 10% w / w of the total weight of the foam, at least about 15% w / w of the total weight of the foam, at least about 20% w / w of the total weight of the foam, at least about 25% w / w of the total weight of the foam, or at least about 30% w / w of the total weight of the foam. In some instances, the chelator composition in the foam is present at a concentration of at most about 0.05%Attorney Docket No.63230-732.601 w / w of the total weight of the foam, at most about 0.1% w / w of the total weight of the foam, at most about 0.5% w / w of the total weight of the foam, at most about 1% w / w of the total weight of the foam, at most about 5% w / w of the total weight of the foam, at most about 10% w / w of the total weight of the foam, at most about 15% w / w of the total weight of the foam, at most about 20% w / w of the total weight of the foam, at most about 25% w / w of the total weight of the foam, or at most about 30% w / w of the total weight of the foam.

[0200] In some instances, the composition is dispensed using a foam dispenser. Cleanser

[0201] In some instances, the composition to remove metals from hair comprises a chelator composition comprising at least one chelating agent, at least one antioxidant, and at least one anti- redeposition agent, and the composition is formulated as a cleanser. In some instances, the cleanser further comprises a surfactant, a salt, a thickener, or a combination thereof. In some instances, the cleanser further comprises a surfactant, a salt, a thickener, or a combination thereof. Methods to formulate the composition as a cleanser is known in the art and can be used for the composition described in the present disclosure.

[0202] In some instances, the surfactant comprises an anionic surfactant, an amphoteric surfactant, a nonionic surfactant, a biosurfactant, or a combination thereof. In some instances, the anionic surfactants can also provide a stable rheology in addition to being efficient cleanser. In some instances, the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium xylenesulfonate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium 2-sulfolaurate, sodium myreth sulfate, sodium xylenesulfonate, sodium C14-16olefin sulfonate, sodium C14-16alpha olefin sulfonate, disodium lauryl sulfosuccinate, sodium methyl cocoyl taurate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium cocoyl sarcosinate, sodium lauroyl sarcosinate, sodium myristoyl sarcosinate, lauroyl sarcosine, cocoyl sarcosine, myristoyl sarcosine, oleoyl sarcosine, myristoyl / stearoyl sarcosine, sodium lauroyl glutamate, sodium cocoyl glutamate, disodium cocoyl glutamate, cocoyl glutamic acid, lauroyl glutamic acid, potassium cocoyl glutamate, potassium lauroyl glutamate, potassium myristoyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, disodium stearoyl glutamate, sodium palmitoyl glutamate, sodium lauroyl lactylate, sodium astrocaryum murumuruate, sodium laurylglucoside hydroxypropylsulfonate, disodium laurylglucoside hydroxypropyl citrate, sodium hydroxypropylsulfonate laurylglucoside crosspolymer, dioctyl sodium sulfosuccinate, or a combination thereof.Attorney Docket No.63230-732.601

[0203] In some instances, single-surfactant systems often lack one aspect or another and it is preferential to utilize a blend. In some instances, amphoteric surfactants can provide gentleness and improve sensory profiles. In some instances, the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauryl betaine, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium dilauramidoglutamide lysine, sodium cocoamphopropionate, lauroamphoacetate, or a combination thereof.

[0204] In some instances, the nonionic surfactant comprises decyl glucoside, lauryl glucoside, coco-glucoside, cocoyl methyl glucamide, capryloyl / caproyl methyl glucamide, lauroyl / myristoyl methyl glucamide, cocamidopropylamine oxide, decylamine oxide, or a combination thereof.

[0205] Biosurfactants represent another type of surfactant that holds the added benefit of superior environmental compatibility, be that more sustainable source materials, improved biodegradability, or greener manufacturing. In some instances, the biosurfactant comprises Sapindus mukorossi (soapnut) extract, saponin, lipopeptide, canola sophorolipid, potassium cocoyl hydrolyzed oat protein, starmella bombicola / Brassica oil ferment, glycoside, glycolipid, rhamnolipid, phospholipid, sophorolipid, and a combination thereof.

[0206] In some instances, the surfactant in the cleanser is present at a concentration of about 0.1% w / w to about 90% w / w, about 0.1% w / w to about 80% w / w, about 0.1% w / w to about 70% w / w, about 0.1% w / w to about 60% w / w, about 0.1% w / w to about 50% w / w, about 0.1% w / w to about 40% w / w, about 0.1% w / w to about 30% w / w, or about 1% w / w to about 20% w / w of a total weight of the cleanser. In some instances, the surfactant in the cleanser is present at a concentration of about 0.1% w / w, about 0.5% w / w, about 1% w / w, about 5% w / w, about 10% w / w, about 15% w / w, about 20% w / w, about 25% w / w, about 30% w / w, about 35% w / w, about 40% w / w, about 45% w / w, about 50% w / w, about 55% w / w, about 60% w / w, about 65% w / w, about 70% w / w, about 75% w / w, about 80% w / w, about 85% w / w, or about 90% w / w of a total weight of the cleanser. In some instances, the surfactant in the cleanser is present at a concentration of at least about 0.1% w / w, at least about 0.5% w / w, at least about 1% w / w, at least about 5% w / w, at least about 10% w / w, at least about 15% w / w, at least about 20% w / w, at least about 25% w / w, at least about 30% w / w, at least about 35% w / w, at least about 40% w / w, at least about 45% w / w, at least about 50% w / w, at least about 55% w / w, at least about 60% w / w, at least about 65% w / w, at least about 70% w / w, at least about 75% w / w, at least about 80% w / w, at least about 85% w / w, or at least about 90% w / w of a total weight of the cleanser. In some instances, the surfactant in the cleanser is present at a concentration of at most about 0.1% w / w, at most about 0.5% w / w, at mostAttorney Docket No.63230-732.601 about 1% w / w, at most about 5% w / w, at most about 10% w / w, at most about 15% w / w, at most about 20% w / w, at most about 25% w / w, at most about 30% w / w, at most about 35% w / w, at most about 40% w / w, at most about 45% w / w, at most about 50% w / w, at most about 55% w / w, at most about 60% w / w, at most about 65% w / w, at most about 70% w / w, at most about 75% w / w, at most about 80% w / w, at most about 85% w / w, or at most about 90% w / w of a total weight of the cleanser.

[0207] In some instances, the salt is added to the cleanser to modulates a viscosity of the composition. In some instances, the salt modulates a viscosity of the composition. In some instances, the salt comprises sodium chloride, magnesium chloride, calcium chloride, sodium perchlorate, sodium sulfate, calcium sulfate, or a combination thereof. In some instances, the salt comprises calcium chloride, magnesium chloride, magnesium sulfate, potassium chloride, potassium glycol sulfate, sodium chloride, or a combination thereof.

[0208] In some instances, the thickener is added to the cleanser to increase a viscosity of the composition. In some instances, the thickener increases a viscosity of the composition. In some instances, the thickener comprises a polysaccharide, a lipid, a mineral, or a combination thereof. In some instances, the polysaccharide of the thickener comprises cellulose, carboxymethyl hydroxyethylcellulose, cellulose acetate propionate carboxylate, hydroxyethylcellulose, hydroxyethyl ethylcellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, methyl hydroxyethylcellulose, microcrystalline cellulose, sodium cellulose sulfate, or a combination thereof. In some instances, the lipid comprises cetyl alcohol, stearic acid, carnauba wax, or a combination thereof. In some instances, the mineral comprises silica, bentonite, magnesium aluminum silicate, or a combination thereof.

[0209] In some instances, the chelator composition in the cleanser is present at a concentration of about 0.1% w / w to about 30% w / w of a total weight of the cleanser. In some instances, the chelator composition in the cleanser is present at a concentration of about 0.05% w / w to about 30% w / w of a total weight of the cleanser, about 0.1% w / wo to about 30% w / w of a total weight of the cleanser, about 1% w / w to about 30% w / w of the total weight of the cleanser, about 5% w / w to about 30% w / w of the total weight of the cleanser, about 10% w / w to about 30% w / w of the total weight of the cleanser, about 15% w / w to about 30% w / w of the total weight of the cleanser, about 20% w / w to about 30% w / w of the total weight of the cleanser, or about 25% w / w to about 30% w / w of the total weight of the cleanser. In some instances, the chelator composition in the cleanser is present at a concentration of about 5% w / w to about 20% w / w of the total weight of the cleanser, about 10% w / w to about 20% w / w of the total weight of the cleanser, or about 15% w / w to about 20% w / w of the total weight of the cleanser. In some instances, the chelator composition in the cleanser isAttorney Docket No.63230-732.601 present at a concentration of about 0.05% w / w of the total weight of the cleanser, about 0.1% w / w of the total weight of the cleanser, about 0.5% w / w of the total weight of the cleanser, about 1% w / w of the total weight of the cleanser, about 5% w / w of the total weight of the cleanser, about 10% w / w of the total weight of the cleanser, about 15% w / w of the total weight of the cleanser, about 20% w / w of the total weight of the cleanser, about 25% w / w of the total weight of the cleanser, or about 30% w / w of the total weight of the cleanser. In some instances, the chelator composition in the cleanser is present at a concentration of at least about 0.05% w / w of the total weight of the cleanser, at least about 0.1% w / w of the total weight of the cleanser, at least about 0.5% w / w of the total weight of the cleanser, at least about 1% w / w of the total weight of the cleanser, at least about 5% w / w of the total weight of the cleanser, at least about 10% w / w of the total weight of the cleanser, at least about 15% w / w of the total weight of the cleanser, at least about 20% w / w of the total weight of the cleanser, at least about 25% w / w of the total weight of the cleanser, or at least about 30% w / w of the total weight of the cleanser. In some instances, the chelator composition in the cleanser is present at a concentration of at most about 0.05% w / w of the total weight of the cleanser, at most about 0.1% w / w of the total weight of the cleanser, at most about 0.5% w / w of the total weight of the cleanser, at most about 1% w / w of the total weight of the cleanser, at most about 5% w / w of the total weight of the cleanser, at most about 10% w / w of the total weight of the cleanser, at most about 15% w / w of the total weight of the cleanser, at most about 20% w / w of the total weight of the cleanser, at most about 25% w / w of the total weight of the cleanser, or at most about 30% w / w of the total weight of the cleanser.

[0210] In some embodiments, the cleanser further comprises a cosmetically or dermatologically acceptable excipient. Non-limiting examples of the cosmetically or dermatologically acceptable excipient includes, but are not limited to, preservatives, antioxidants, thickeners, chelating agents, co-solvents, sunscreen agents, vitamins, dyes, hair coloring agents, proteins, amino acids, organic polymers, natural extracts such as plant extracts, humectants, fragrances, perfumes, oils, emollients, lubricants, butters, penetrants, thickeners, viscosity modifiers, polymers, resins, hair fixatives, silicones, film formers, surfactants, detergents, emulsifiers, opacifying agents, volatiles, propellants, liquid vehicles, carriers, salts, pH adjusting agents (buffers), neutralizing agents, buffers, hair conditioning agents, anti-static agents, anti-frizz agents, anti-dandruff agents, or a combination thereof. Conditioner

[0211] In some instances, the composition to remove metals from hair comprises a chelator composition comprising at least one chelating agent, at least one antioxidant, and at least one anti- redeposition agent, and the composition is formulated as a conditioner. In some instances,Attorney Docket No.63230-732.601 conditioner can be applied to hair after shampooing and rinsing, which provides conditioning properties to the hair, such as keeping hair moisturized, soft, shine, and smooth. In some instances, conditioner can prevent static, making hair less frizzy. In some instances, conditioner can act as a detangler by lubricating hair follicles. In some instances, the conditioner further comprises a conditioning agent. In some instances, the conditioning agent comprises cationic surfactant, conditioning polymer, or a combination thereof.

[0212] In some instances, the conditioner is prepared by additional shear in process with heat. Other methods to formulate the composition as a conditioner is known in the art and can be used for the composition described in the present disclosure.

[0213] In some instances, the conditioner comprises a cationic surfactant, a silicone (e.g., dimethicone), a quaternary ammonium compound (e.g., cetrimonium chloride, behentrimonium chloride), a fatty alcohol (e.g., cetyl alcohol, stearyl alcohol), a natural oil (e.g., argan oil, coconut oil, jojoba oil), a protein (e.g., hydrolyzed keratin, silk proteins), a humectant (e.g., glycerin, panthenol), a polyquaternium compound (e.g., polyquaternium-7, polyquaternium-10), a cationic polymer (e.g., polyquaternium-16, polyquaternium-37), or a combination thereof.

[0214] In some instances, the chelator composition in the conditioner is present at a concentration of about 0.1% w / w to about 30% w / w of a total weight of the conditioner. In some instances, the chelator composition in the conditioner is present at a concentration of about 0.05% w / w to about 30% w / w of a total weight of the conditioner, about 0.1% w / wo to about 30% w / w of a total weight of the conditioner, about 1% w / w to about 30% w / w of the total weight of the conditioner, about 5% w / w to about 30% w / w of the total weight of the conditioner, about 10% w / w to about 30% w / w of the total weight of the conditioner, about 15% w / w to about 30% w / w of the total weight of the conditioner, about 20% w / w to about 30% w / w of the total weight of the conditioner, or about 25% w / w to about 30% w / w of the total weight of the conditioner. In some instances, the chelator composition in the conditioner is present at a concentration of about 5% w / w to about 20% w / w of the total weight of the conditioner, about 10% w / w to about 20% w / w of the total weight of the conditioner, or about 15% w / w to about 20% w / w of the total weight of the conditioner. In some instances, the chelator composition in the conditioner is present at a concentration of about 0.05% w / w of the total weight of the conditioner, about 0.1% w / w of the total weight of the conditioner, about 0.5% w / w of the total weight of the conditioner, about 1% w / w of the total weight of the conditioner, about 5% w / w of the total weight of the conditioner, about 10% w / w of the total weight of the conditioner, about 15% w / w of the total weight of the conditioner, about 20% w / w of the total weight of the conditioner, about 25% w / w of the total weight of the conditioner, or about 30% w / w of the total weight of the conditioner. In some instances, the chelator composition in theAttorney Docket No.63230-732.601 conditioner is present at a concentration of at least about 0.05% w / w of the total weight of the conditioner, at least about 0.1% w / w of the total weight of the conditioner, at least about 0.5% w / w of the total weight of the conditioner, at least about 1% w / w of the total weight of the conditioner, at least about 5% w / w of the total weight of the conditioner, at least about 10% w / w of the total weight of the conditioner, at least about 15% w / w of the total weight of the conditioner, at least about 20% w / w of the total weight of the conditioner, at least about 25% w / w of the total weight of the conditioner, or at least about 30% w / w of the total weight of the conditioner. In some instances, the chelator composition in the conditioner is present at a concentration of at most about 0.05% w / w of the total weight of the conditioner, at most about 0.1% w / w of the total weight of the conditioner, at most about 0.5% w / w of the total weight of the conditioner, at most about 1% w / w of the total weight of the conditioner, at most about 5% w / w of the total weight of the conditioner, at most about 10% w / w of the total weight of the conditioner, at most about 15% w / w of the total weight of the conditioner, at most about 20% w / w of the total weight of the conditioner, at most about 25% w / w of the total weight of the conditioner, or at most about 30% w / w of the total weight of the conditioner. Emulsion

[0215] In some instances, the composition to remove metals from hair comprises a chelator composition comprising at least one chelating agent, at least one antioxidant, and at least one anti- redeposition agent, and the composition is formulated as an emulsion. As described herein, in some instances, emulsion refers to a multiphasic fluid system, e.g., a mixture of two or more liquids, in which liquid droplets, e.g., dispersed phase, are dispersed in another immiscible liquid, e.g., continuous phase. The emulsion comprises an oil phase and an aqueous phase.

[0216] In some instances, the emulsion is prepared by adding a first phase to a second phase with an emulsifier with a shear force applied. In some instances, heat may be applied to aid emulsification of the two phases. In some instances, to aid emulsification of the two phases, one or both phases can be heated during mixing. In some instances, a homogenizer or a mixer can be utilized to apply mechanical shear to produce emulsion. In some instances, the emulsion is prepared by additional shear in process with heat. In some instances, the emulsion is prepared by additional shear in process under high pressure with heat. Other methods to formulate the composition as an emulsion is known in the art and can be used for the composition described in the present disclosure.

[0217] In some instances, the emulsion comprises an aqueous phase comprising water (a “water phase”) and an oil phase. In some instances, the emulsion is a water in oil (w / o) emulsion. In some instances, the emulsion is an oil in water (o / w) emulsion.Attorney Docket No.63230-732.601

[0218] In some instances, the emulsion comprises an emulsifier that holds the oil phase and the water phase together. Examples of emulsifiers include, but are not limited to: fatty alcohol ethoxylates (e.g., ceteareth-20, ceteareth-25), sorbitan esters (e.g., sorbitan oleate, sorbitan stearate), PEG esters (e.g., PEG-40 hydrogenated castor oil, PEG-100 stearate), quaternary ammonium compounds (e.g., behentrimonium chloride), polyquaternium compounds (e.g., polyquaternium-10), ethoxylated sorbitan esters (e.g., polysorbate 20, polysorbate 80), glyceryl esters (e.g., glyceryl stearate), cationic surfactants (e.g., cetrimonium chloride), nonionic surfactants, nonionic emulsifiers (e.g., glyceryl oleate), and amphiphilic compounds (e.g., lecithin, phospholipids). In some instances, the emulsifier is selected from any one of: lecithin, hydrogenated lecithin, phosphatidylcholine, [C12-16alcohols, palmitic acid], glyceryl behenate, glyceryl stearate, glyceryl stearate citrate, glyceryl oleate citrate, sorbitan laurate, lauryl laurate, sorbitan olivate, cetearyl olivate, sodium stearoyl lactylate, sodium stearoyl glutamate, sodium cocoyl glutamate, caprylyl / capryl glucoside, polyhydroxystearic acid, phenethyl alcohol, sodium surfactin, polyglycerin-3, polyglyceryl-3 distearate, polyglyceryl-3 diisostearate, polyglyceryl-3 cocoate, polyglyceryl-3 dicitrate / stearate, polyglyceryl-3 beeswax, polyglyceryl-3 polyricinoleate, polyglyceryl-4 oleate, polyglyceryl-4 caprate, polylgylceryl-4 laurate, polyglyceryl-6 caprylate, polyglyceryl-6 stearate, polyglyceryl-6 distearate, polyglyceryl-6 behenate, polyglyceryl-6 polyhydroxystearate, polyglyceryl-6 oleate, polyglyceryl-6 ricinoleate, polyglyceryl-6 polyricinoleate, polyglyceryl-10 laurate, candelilla / jojoba / rice bran polyglyceryl-3 esters, stearoyl glutamic acid, stearyl alcohol, glyceryl stearate citrate, glyceryl oleate citrate, polyglyceryl-3 distearate, glyceryl stearate citrate, polyglyceryl-3 dicitrate / stearate, candelilla / jojoba / rice bran polyglyceryl-3 esters, polyglyceryl-6 stearate, polyglyceryl-6 behenate, polysorbate-20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, or polyhydroxystearic acid. In some instances, the nonionic surfactant comprises decyl glucoside, lauryl glucoside, coco- glucoside, cocoyl methyl glucamide, capryloyl / caproyl methyl glucamide, lauroyl / myristoyl methyl glucamide, cocamidopropylamine oxide, decylamine oxide, or a combination thereof.

[0219] In some instances, the emulsifier is present at a concentration of about 1% w / w to about 10% w / w of a total weight of the composition, about 2% w / w to about 10% w / w of a total weight of the composition, about 3% w / w to about 10% w / w of a total weight of the composition, about 4% w / w to about 10% w / w of a total weight of the composition, about 5% w / w to about 10% w / w of a total weight of the composition, about 6% w / w to about 10% w / w of a total weight of the composition, about 7% w / w to about 10% w / w of a total weight of the composition, about 8% w / w to about 10% w / w of a total weight of the composition, or about 9% w / w to about 10% w / w of aAttorney Docket No.63230-732.601 total weight of the composition. In some instances, the emulsifier is present at a concentration of about 1% w / w of a total weight of the composition, about 2% w / w of a total weight of the composition, about 3% w / w of a total weight of the composition, about 4% w / w of a total weight of the composition, about 5% w / w of a total weight of the composition, about 6% w / w of a total weight of the composition, about 7% w / w of a total weight of the composition, about 8% w / w of a total weight of the composition, about 9% w / w of a total weight of the composition, or about 10% w / w of a total weight of the composition. In some instances, the emulsifier is present at a concentration of at least about 1% w / w of a total weight of the composition, at least about 2% w / w of a total weight of the composition, at least about 3% w / w of a total weight of the composition, at least about 4% w / w of a total weight of the composition, at least about 5% w / w of a total weight of the composition, at least about 6% w / w of a total weight of the composition, at least about 7% w / w of a total weight of the composition, at least about 8% w / w of a total weight of the composition, at least about 9% w / w of a total weight of the composition, or at least about 10% w / w of a total weight of the composition. In some instances, the emulsifier is present at a concentration of at most about 1% w / w of a total weight of the composition, at most about 2% w / w of a total weight of the composition, at most about 3% w / w of a total weight of the composition, at most about 4% w / w of a total weight of the composition, at most about 5% w / w of a total weight of the composition, at most about 6% w / w of a total weight of the composition, at most about 7% w / w of a total weight of the composition, at most about 8% w / w of a total weight of the composition, at most about 9% w / w of a total weight of the composition, or at most about 10% w / w of a total weight of the composition.

[0220] In some instances, the chelator composition in the emulsion is present at a concentration of about 0.1% w / w to about 30% w / w of a total weight of the emulsion. In some instances, the chelator composition in the emulsion is present at a concentration of about 0.05% w / w to about 30% w / w of a total weight of the emulsion, about 0.1% w / wo to about 30% w / w of a total weight of the emulsion, about 1% w / w to about 30% w / w of the total weight of the emulsion, about 5% w / w to about 30% w / w of the total weight of the emulsion, about 10% w / w to about 30% w / w of the total weight of the emulsion, about 15% w / w to about 30% w / w of the total weight of the emulsion, about 20% w / w to about 30% w / w of the total weight of the emulsion, or about 25% w / w to about 30% w / w of the total weight of the emulsion. In some instances, the chelator composition in the emulsion is present at a concentration of about 5% w / w to about 20% w / w of the total weight of the emulsion, about 10% w / w to about 20% w / w of the total weight of the emulsion, or about 15% w / w to about 20% w / w of the total weight of the emulsion. In some instances, the chelator composition in the emulsion is present at a concentration of about 0.05% w / w of the total weight of theAttorney Docket No.63230-732.601 emulsion, about 0.1% w / w of the total weight of the emulsion, about 0.5% w / w of the total weight of the emulsion, about 1% w / w of the total weight of the emulsion, about 5% w / w of the total weight of the emulsion, about 10% w / w of the total weight of the emulsion, about 15% w / w of the total weight of the emulsion, about 20% w / w of the total weight of the emulsion, about 25% w / w of the total weight of the emulsion, or about 30% w / w of the total weight of the emulsion. In some instances, the chelator composition in the emulsion is present at a concentration of at least about 0.05% w / w of the total weight of the emulsion, at least about 0.1% w / w of the total weight of the emulsion, at least about 0.5% w / w of the total weight of the emulsion, at least about 1% w / w of the total weight of the emulsion, at least about 5% w / w of the total weight of the emulsion, at least about 10% w / w of the total weight of the emulsion, at least about 15% w / w of the total weight of the emulsion, at least about 20% w / w of the total weight of the emulsion, at least about 25% w / w of the total weight of the emulsion, or at least about 30% w / w of the total weight of the emulsion. In some instances, the chelator composition in the emulsion is present at a concentration of at most about 0.05% w / w of the total weight of the emulsion, at most about 0.1% w / w of the total weight of the emulsion, at most about 0.5% w / w of the total weight of the emulsion, at most about 1% w / w of the total weight of the emulsion, at most about 5% w / w of the total weight of the emulsion, at most about 10% w / w of the total weight of the emulsion, at most about 15% w / w of the total weight of the emulsion, at most about 20% w / w of the total weight of the emulsion, at most about 25% w / w of the total weight of the emulsion, or at most about 30% w / w of the total weight of the emulsion.

[0221] In various instances, the aqueous phase of the emulsion is an anhydrous phase. In some instances, the anhydrous phase enables delivering compounds or agents that are sensitive to hydrolysis or oxidation. In some instances, the anhydrous phase is substantially free of water. In some instances, the anhydrous emulsion system comprises a water-soluble solvent, phospholipid- based system, or silicone-based system. In some embodiments, the water-soluble solvent comprises propylene glycol, butylene glycol, ethylene glycol, PEG-200, glycerin, or a combination thereof. In some instances, the silicone-based system comprises polyol-in-silicone anhydrous emulsion system, which as a polar phase with polyol to replace water, and a nonpolar phase with silicone oil. Examples of polyol include, but are not limited to, propylene glycol, butylene glycol, and glycerin. In some instances, the anhydrous phase comprises a natural oil, a fatty alcohol, a silicone, a natural butter, a synthetic ester, or a combination thereof.

[0222] In some instances, the anhydrous phase has less than about 1% w / w water of a weight of the anhydrous phase, less than about 2% w / w water of a weight of the anhydrous phase, less than about 3% w / w water of a weight of the anhydrous phase, less than about 4% w / w water of a weight of the anhydrous phase, or less than about 5% w / w water of a weight of the anhydrous phase.Attorney Docket No.63230-732.601

[0223] In some instances, the chelator composition is dispersed within the water phase of the emulsion. In some instances, the chelator composition is dispersed within the oil phase of the emulsion. In some instances, the chelator composition is dispersed within the anhydrous phase of the emulsion. Gel

[0224] In some instances, the composition to remove metals from hair comprises a chelator composition comprising at least one chelating agent, at least one antioxidant, and at least one anti- redeposition agent, and the composition is formulated as a gel. In some instances, gel can be used for hair styling, such as maintaining or setting hair in a particular shape.

[0225] In some instances, the gel is prepared by additional shear in process with heat. Other methods to formulate the composition as a gel is known in the art and can be used for the composition described in the present disclosure.

[0226] In some instances, the gel further comprises a thickening agent or a thickener. In some instances, the thickening agent increases a viscosity of the composition when dispersed or dissolved in water or a water-soluble solvent. In some instances, the thickening agent comprises a carboxylic acid polymer, a crosslinked polyacrylate polymer, a polyacrylamide polymer, a polysaccharide, a gum, or a combination thereof. In some instances, the carboxylic acid polymer comprises a carbomer, acrylic acid, substituted acrylic acid, or a salt or ester thereof, each monomer of the carboxylic acid polymer is connected via a double bond. In some instances, the carboxylic acid polymer is Carbopol® 900, Carbopol® 954, Ultrez® 10, C10-30alkyl acrylates with at least one monomers of acrylic acid, methacrylic acid, or a short chain ester (e.g., C1-4) thereof. In some instances, the crosslinked polyacrylate polymer comprises a carbomer, acrylic acid, substituted acrylic acid, or a salt or ester thereof, each monomer of the carboxylic acid polymer is connected via a double bond.

[0227] In some instances, the polyacrylamide polymer is branched or unbranched. In some instances, the polyacrylamide polymer comprises isoparaffin and laureth-7, e.g., Sepigel 305TM. In some instances, the polyacrylamide polymer comprises a multi-block copolymer of unsubstituted acrylamides and substituted acrylamides. In some instances, the multiblock-copolymer is Hypan SR150H, SS500V, SS500W, SSSA100H, or a combination thereof.

[0228] In some instances, the polysaccharide comprises cellulose, carboxymethyl hydroxyethylcellulose, cellulose acetate propionate carboxylate, hydroxyethylcellulose, hydroxyethyl ethylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, methyl hydroxyethylcellulose, microcrystalline cellulose, sodium cellulose sulfate, or a combination thereof. In some instances, the polysaccharide comprises an alkyl-substituted cellulose. In someAttorney Docket No.63230-732.601 instances, the alkyl-substituted cellulose is a methylcellulose, a hydroxyethylcellulose, a carboxymethylcellulose, or an acylated derivative thereof. In some instances, the polysaccharide comprises a scleroglucan comprising a linear chain of one to three glucose units connected by 1,6- linkages every three glucose units, e.g., ClearogelTM.

[0229] In some instances, the gum comprises acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan, carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hectorite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, or biosaccharide gum, or a combination thereof.

[0230] In some instances, the thickening agent comprises xanthan gum, guar gum, biosaccharide gum, cellulose, gum acacia, sclerotium gum, agarose, pectin, gellan gum, hyaluronic acid, or a combination thereof. In some instances, the thickening agent comprises polymeric thickening agents selected from the group consisting of ammonium polyacryloyldimethyl taurate, ammonium acryloyldimethyltaurate / vinylpyrrolidone copolymer, sodium polyacrylate, acrylate copolymer, polyacrylamide, carbomer, acrylate / C10-30 alkyl acrylate crosspolymer, acrylamide / sodium acryloyldimethyltaurate copolymer, or a combination thereof.

[0231] In some instances, the gel further comprises a film-forming agent. In some instances, as described herein, film-forming agent forms or provides a film over the hair. In some instances, the film-forming agent imparts a smooth feel to hair. In some instances, the film-forming agent forms a continuous surface over a region of the hair. In some instances, the film-forming agent comprises a carbomer, a lipid, a polymer, a copolymer, a crosspolymer, a saccharide, a polyquaternium compound, a protein, or a combination thereof. In some instances, the carbomer is sodium carbomer. In some instances, the lipid is diisopropyl adipate, diisopropyl sebacate, dipentaerythrityl tri-polyhydroxystearate, di-PPG-3 myristyl ether adipate, glycerol triacetate, PPG-3 benzyl ether myristate, tridecyl trimellitate, or a combination thereof. In some instances, the polymer is ammonium polyacrylate, polyvinyl alcohol, polyvinylpyrrolidone (PVP), polyvinyl acetate (PVAc), acrylate (e.g., polymethyl methacrylate (PMMA)), glyceryl polymethacrylate, polyacrylamide (e.g., polyamide-8), polyacrylate-17, polyester-8, polyethylene, polymethylsilsesquioxane, sodium polyacrylate, or a combination thereof. In some instances, the copolymer is dilinoleic acid propanediol copolymer, acrylates / dimethicone copolymer, acrylates / steareth-20 methacrylate copolymer, acrylates copolymer, adipic acid / neopentyl glycol / trimellitic anhydride copolymer, ammonium acryloyldimethyltaurate / VP copolymer, capryloyl glycerin / sebacic acid copolymer,Attorney Docket No.63230-732.601 hydrogenated styrene / isoprene copolymer, PPG-12 / SMDI copolymer, PVM / MA copolymer, PVP / dimethylaminoethylmethacrylate, PVP copolymer, sodium acrylate copolymer, VA / crotonate copolymer, VP / eicosene copolymer, VP / hexadecene copolymer, VP / VA copolymer, or a combination thereof. In some instances, the crosspolymer is allyl methacrylate crosspolymer, methyl methacrylate / glycol dimethacrylate crosspolymer, polyacrylate crosspolymer, PVM / MA decadiene crosspolymer, triethoxycaprylylsilane crosspolymer, sodium hyaluronate crosspolymer, or a combination thereof. In some instances, the saccharide is fructan, biosaccharide gum-1, ethylcellulose, hydrogenated starch hydrolysate, hydroxyethylcellulose, hydroxypropyl guar, hydroxypropyl methylcellulose, maltodextrin, maltooligosyl glucoside, polyglucuronic acid, rhizobian gum, zea mays corn starch, or a combination thereof. In some instances, the polyquaternium compound is polyquaternium-10, polyquaternium 39, polyquaternium-51, polyquaternium-7, or a combination thereof. In some instances, the protein is albumin, triticum vulgare (wheat) protein, wheat protein, or a combination thereof.

[0232] In some instances, the film-forming agent comprises acetyl tributyl citrate, albumin, ammonium polyacrylate, dilinoleic acid propanediol copolymer, plasticizing agent, polyvinyl alcohol, fructan, acrylate, acrylates / dimethicone copolymer, acrylates / steareth-20 methacrylate copolymer, acrylates copolymer, adipic acid / neopentyl glycol / trimellitic anhydride copolymer, allyl methacrylate crosspolymer, ammonium acryloyldimethyltaurate / VP copolymer, biosaccharide gum-1, capryloyl glycerin / sebacic acid copolymer, carnauba wax, dibutyl adipate, diisopropyl adipate, diisopropyl sebacate, dipentaerythrityl tri-polyhydroxystearate, di-PPG-3 myristyl ether adipate, ethylcellulose, glycerol triacetate, glyceryl polymethacrylate, hydrogenated starch hydrolysate, hydrogenated styrene / isoprene copolymer, hydroxyethylcellulose, hydroxypropyl guar, hydroxypropyl methylcellulose, maltodextrin, maltooligosyl glucoside, methyl methacrylate / glycol dimethacrylate crosspolymer, polyacrylamide, polyacrylate-17, polyacrylate crosspolymer, polyamide-8, polyester-8, polyethylene, polyglucuronic acid, polyisobutene, polymethylsilsesquioxane, polyquaternium-10, polyquaternium 39, polyquaternium-51, polyquaternium-7, PPG-12 / SMDI copolymer, PPG-3 benzyl ether myristate, PVM / MA copolymer, PVM / MA decadiene crosspolymer, PVP, PVP / dimethylaminoethylmethacrylate, PVP copolymer, rhizobian gum, siloxane, sodium acrylates copolymer, sodium carbomer, sodium polyacrylate, tridecyl trimellitate, triethoxycaprylylsilane crosspolymer, triticum vulgare (wheat) protein, VA / crotonate copolymer, VP / eicosene copolymer, VP / hexadecene copolymer, VP / VA copolymer, wheat protein, zea mays corn starch, albumen, balsam peru, or a combination thereof.

[0233] In some instances, the gel further comprises water or a water-soluble solvent, e.g., ethanol, propanol, isopropanol, and the like.Attorney Docket No.63230-732.601

[0234] In some instances, the thickening agent in the gel is present a concentration of about 0.01 % w / w to about 30% w / w of a total weight of the gel. In some instances, the thickening agent in the gel is present at a concentration of about 0.05% w / w to about 30% w / w of a total weight of the gel, about 0.1% w / wo to about 30% w / w of a total weight of the gel, about 1% w / w to about 30% w / w of the total weight of the gel, about 5% w / w to about 30% w / w of the total weight of the gel, about 10% w / w to about 30% w / w of the total weight of the gel, about 15% w / w to about 30% w / w of the total weight of the gel, about 20% w / w to about 30% w / w of the total weight of the gel, or about 25% w / w to about 30% w / w of the total weight of the gel. In some instances, the thickening agent in the gel is present at a concentration of about 5% w / w to about 20% w / w of the total weight of the gel, about 10% w / w to about 20% w / w of the total weight of the gel, or about 15% w / w to about 20% w / w of the total weight of the gel. In some instances, the thickening agent in the gel is present at a concentration of about 0.05% w / w of the total weight of the gel, about 0.1% w / w of the total weight of the gel, about 0.5% w / w of the total weight of the gel, about 1% w / w of the total weight of the gel, about 5% w / w of the total weight of the gel, about 10% w / w of the total weight of the gel, about 15% w / w of the total weight of the gel, about 20% w / w of the total weight of the gel, about 25% w / w of the total weight of the gel, or about 30% w / w of the total weight of the gel. In some instances, the thickening agent in the gel is present at a concentration of at least about 0.05% w / w of the total weight of the gel, at least about 0.1% w / w of the total weight of the gel, at least about 0.5% w / w of the total weight of the gel, at least about 1% w / w of the total weight of the gel, at least about 5% w / w of the total weight of the gel, at least about 10% w / w of the total weight of the gel, at least about 15% w / w of the total weight of the gel, at least about 20% w / w of the total weight of the gel, at least about 25% w / w of the total weight of the gel, or at least about 30% w / w of the total weight of the gel. In some instances, the thickening agent in the gel is present at a concentration of at most about 0.05% w / w of the total weight of the gel, at most about 0.1% w / w of the total weight of the gel, at most about 0.5% w / w of the total weight of the gel, at most about 1% w / w of the total weight of the gel, at most about 5% w / w of the total weight of the gel, at most about 10% w / w of the total weight of the gel, at most about 15% w / w of the total weight of the gel, at most about 20% w / w of the total weight of the gel, at most about 25% w / w of the total weight of the gel, or at most about 30% w / w of the total weight of the gel.

[0235] In some instances, the chelator composition in the gel is present at a concentration of about 0.1% w / w to about 30% w / w of a total weight of the gel. In some instances, the chelator composition in the gel is present at a concentration of about 0.05% w / w to about 30% w / w of a total weight of the gel, about 0.1% w / wo to about 30% w / w of a total weight of the gel, about 1% w / w to about 30% w / w of the total weight of the gel, about 5% w / w to about 30% w / w of the totalAttorney Docket No.63230-732.601 weight of the gel, about 10% w / w to about 30% w / w of the total weight of the gel, about 15% w / w to about 30% w / w of the total weight of the gel, about 20% w / w to about 30% w / w of the total weight of the gel, or about 25% w / w to about 30% w / w of the total weight of the gel. In some instances, the chelator composition in the gel is present at a concentration of about 5% w / w to about 20% w / w of the total weight of the gel, about 10% w / w to about 20% w / w of the total weight of the gel, or about 15% w / w to about 20% w / w of the total weight of the gel. In some instances, the chelator composition in the gel is present at a concentration of about 0.05% w / w of the total weight of the gel, about 0.1% w / w of the total weight of the gel, about 0.5% w / w of the total weight of the gel, about 1% w / w of the total weight of the gel, about 5% w / w of the total weight of the gel, about 10% w / w of the total weight of the gel, about 15% w / w of the total weight of the gel, about 20% w / w of the total weight of the gel, about 25% w / w of the total weight of the gel, or about 30% w / w of the total weight of the gel. In some instances, the chelator composition in the gel is present at a concentration of at least about 0.05% w / w of the total weight of the gel, at least about 0.1% w / w of the total weight of the gel, at least about 0.5% w / w of the total weight of the gel, at least about 1% w / w of the total weight of the gel, at least about 5% w / w of the total weight of the gel, at least about 10% w / w of the total weight of the gel, at least about 15% w / w of the total weight of the gel, at least about 20% w / w of the total weight of the gel, at least about 25% w / w of the total weight of the gel, or at least about 30% w / w of the total weight of the gel. In some instances, the chelator composition in the gel is present at a concentration of at most about 0.05% w / w of the total weight of the gel, at most about 0.1% w / w of the total weight of the gel, at most about 0.5% w / w of the total weight of the gel, at most about 1% w / w of the total weight of the gel, at most about 5% w / w of the total weight of the gel, at most about 10% w / w of the total weight of the gel, at most about 15% w / w of the total weight of the gel, at most about 20% w / w of the total weight of the gel, at most about 25% w / w of the total weight of the gel, or at most about 30% w / w of the total weight of the gel. Paste

[0236] In some instances, the composition to remove metals from hair comprises a chelator composition comprising at least one chelating agent, at least one antioxidant, and at least one anti- redeposition agent, and the composition is formulated as a paste.

[0237] In some instances, the paste is prepared by extrusion. In some instances, the paste is prepared under elevated temperature, e.g., with heat. Other methods to formulate the composition as a paste is known in the art and can be used for the composition described in the present disclosure.Attorney Docket No.63230-732.601

[0238] In some instances, the paste comprises a wax (e.g., carnauba wax), a polymer (e.g., hyaluronic acid), a filler (e.g., clay or amorphous silica), a binder (e.g., vinylpyrrolidone), a lubricant (e.g., polyol stearates or alkali or alkaline earth metal stearates), a coloring agent or a mattifying agent (e.g., titanium oxide), an anionic surfactant (e.g., lauryl sulfate), an amphoteric surfactant (e.g., cocamidopropyl hydroxysultaine), a nonionic surfactant (e.g., coco-glucoside), a vitamin (e.g., vitamin E), or a combination thereof. In some instances, the wax comprises paraffin, ozokerite, polyethylene wax, synthetic wax, microcrystalline wax, carnauba wax, lanolin wax, candelilla wax, beeswax, hydrogenated vegetable oil, or a combination thereof. In some instances, the polymer comprises an acrylamide, a vinylpyrrolidone (e.g., polyvinylpyrrolidone (PVP)), an acrylate (e.g., methacrylate), or a combination thereof.

[0239] In some instances, the wax is present at a concentration of about 0.1% w / w to about 80% w / w of a total weight of the composition, about 0.5% w / w to about 80% w / w of a total weight of the composition, about 1% w / w to about 80% w / w of a total weight of the composition, about 5% w / w to about 80% w / w of a total weight of the composition, about 10% w / w to about 80% w / w of a total weight of the composition, about 15% w / w to about 80% w / w of a total weight of the composition, about 20% w / w to about 80% w / w of a total weight of the composition, about 25% w / w to about 80% w / w of a total weight of the composition, about 30% w / w to about 80% w / w of a total weight of the composition, about 35% w / w to about 80% w / w of a total weight of the composition, about 40% w / w to about 80% w / w of a total weight of the composition, about 45% w / w to about 80% w / w of a total weight of the composition, about 50% w / w to about 80% w / w of a total weight of the composition, about 55% w / w to about 80% w / w of a total weight of the composition, about 60% w / w to about 80% w / w of a total weight of the composition, about 65% w / w to about 80% w / w of a total weight of the composition, about 70% w / w to about 80% w / w of a total weight of the composition, or about 75% w / w to about 80% w / w of a total weight of the composition. In some instances, the wax is present at a concentration of about 0.1% w / w of a total weight of the composition, about 0.5% w / w of a total weight of the composition, about 1% w / w of a total weight of the composition, about 5% w / w of a total weight of the composition, about 10% w / w of a total weight of the composition, about 15% w / w of a total weight of the composition, about 20% w / w of a total weight of the composition, about 25% w / w of a total weight of the composition, about 30% w / w of a total weight of the composition, about 35% w / w of a total weight of the composition, about 40% w / w of a total weight of the composition, about 45% w / w of a total weight of the composition, about 50% w / w of a total weight of the composition, about 55% w / w of a total weight of the composition, about 60% w / w of a total weight of the composition, about 65% w / w of a total weight of the composition, about 70% w / w of a total weight of the composition,Attorney Docket No.63230-732.601 about 75% w / w of a total weight of the composition, or about 80% w / w of a total weight of the composition. In some instances, the wax is present at a concentration of at least about 0.1% w / w of a total weight of the composition, at least about 0.5% w / w of a total weight of the composition, at least about 1% w / w of a total weight of the composition, at least about 5% w / w of a total weight of the composition, at least about 10% w / w of a total weight of the composition, at least about 15% w / w of a total weight of the composition, at least about 20% w / w of a total weight of the composition, at least about 25% w / w of a total weight of the composition, at least about 30% w / w of a total weight of the composition, at least about 35% w / w of a total weight of the composition, at least about 40% w / w of a total weight of the composition, at least about 45% w / w of a total weight of the composition, at least about 50% w / w of a total weight of the composition, at least about 55% w / w of a total weight of the composition, at least about 60% w / w of a total weight of the composition, at least about 65% w / w of a total weight of the composition, at least about 70% w / w of a total weight of the composition, at least about 75% w / w of a total weight of the composition, or at least about 80% w / w of a total weight of the composition. In some instances, the wax is present at a concentration of at most about 0.1% w / w of a total weight of the composition, at most about 0.5% w / w of a total weight of the composition, at most about 1% w / w of a total weight of the composition, at most about 5% w / w of a total weight of the composition, at most about 10% w / w of a total weight of the composition, at most about 15% w / w of a total weight of the composition, at most about 20% w / w of a total weight of the composition, at most about 25% w / w of a total weight of the composition, at most about 30% w / w of a total weight of the composition, at most about 35% w / w of a total weight of the composition, at most about 40% w / w of a total weight of the composition, at most about 45% w / w of a total weight of the composition, at most about 50% w / w of a total weight of the composition, at most about 55% w / w of a total weight of the composition, at most about 60% w / w of a total weight of the composition, at most about 65% w / w of a total weight of the composition, at most about 70% w / w of a total weight of the composition, at most about 75% w / w of a total weight of the composition, or at most about 80% w / w of a total weight of the composition.

[0240] In some instances, the chelator composition is present at a concentration of about 0.1% w / w to about 30% w / w of a total weight of the paste. In some instances, the chelator composition in the paste is present at a concentration of about 0.05% w / w to about 30% w / w of a total weight of the paste, about 0.1% w / wo to about 30% w / w of a total weight of the paste, about 1% w / w to about 30% w / w of the total weight of the paste, about 5% w / w to about 30% w / w of the total weight of the paste, about 10% w / w to about 30% w / w of the total weight of the paste, about 15% w / w to about 30% w / w of the total weight of the paste, about 20% w / w to about 30% w / w of the totalAttorney Docket No.63230-732.601 weight of the paste, or about 25% w / w to about 30% w / w of the total weight of the paste. In some instances, the chelator composition in the paste is present at a concentration of about 5% w / w to about 20% w / w of the total weight of the paste, about 10% w / w to about 20% w / w of the total weight of the paste, or about 15% w / w to about 20% w / w of the total weight of the paste. In some instances, the chelator composition in the paste is present at a concentration of about 0.05% w / w of the total weight of the paste, about 0.1% w / w of the total weight of the paste, about 0.5% w / w of the total weight of the paste, about 1% w / w of the total weight of the paste, about 5% w / w of the total weight of the paste, about 10% w / w of the total weight of the paste, about 15% w / w of the total weight of the paste, about 20% w / w of the total weight of the paste, about 25% w / w of the total weight of the paste, or about 30% w / w of the total weight of the paste. In some instances, the chelator composition in the paste is present at a concentration of at least about 0.05% w / w of the total weight of the paste, at least about 0.1% w / w of the total weight of the paste, at least about 0.5% w / w of the total weight of the paste, at least about 1% w / w of the total weight of the paste, at least about 5% w / w of the total weight of the paste, at least about 10% w / w of the total weight of the paste, at least about 15% w / w of the total weight of the paste, at least about 20% w / w of the total weight of the paste, at least about 25% w / w of the total weight of the paste, or at least about 30% w / w of the total weight of the paste. In some instances, the chelator composition in the paste is present at a concentration of at most about 0.05% w / w of the total weight of the paste, at most about 0.1% w / w of the total weight of the paste, at most about 0.5% w / w of the total weight of the paste, at most about 1% w / w of the total weight of the paste, at most about 5% w / w of the total weight of the paste, at most about 10% w / w of the total weight of the paste, at most about 15% w / w of the total weight of the paste, at most about 20% w / w of the total weight of the paste, at most about 25% w / w of the total weight of the paste, or at most about 30% w / w of the total weight of the paste.

[0241] In some instances, the paste has a viscosity of about 3,000 centipoises (cP) to about 300,000 cP, about 6,000 cP to about 300,000 cP, about 9,000 cP to about 300,000 cP, about 12,000 cP to about 300,000 cP, about 15,000 cP to about 300,000 cP, about 18,000 cP to about 300,000 cP, about 21,000 cP to about 300,000 cP, about 24,000 cP to about 300,000 cP, about 27,000 cP to about 300,000 cP, about 30,000 cP to about 300,000 cP, about 50,000 cP to about 300,000 cP, about 100,000 cP to about 300,000 cP, about 150,000 cP to about 300000 cP, about 200,000 cP to about 300,000 cP, or about 250,000 cP to about 300,000 cP. In some instances, the paste has a viscosity of about 3,000 cP, about 6,000 cP, about 9,000 cP, about 12,000 cP, about 15,000 cP, about 18,000 cP, about 21,000 cP, about 24,000 cP, about 27,000 cP, about 30,000 cP, about 50,000 cP, about 100,000 cP, about 150,000 cP, about 200,000 cP, about 250,000 cP, or aboutAttorney Docket No.63230-732.601 300,000 cP. In some instances, the paste has a viscosity of at least about 3,000 cP, at least about 6,000 cP, at least about 9,000 cP, at least about 12,000 cP, at least about 15,000 cP, at least about 18,000 cP, at least about 21,000 cP, at least about 24,000 cP, at least about 27,000 cP, at least about 30,000 cP, at least about 50,000 cP, at least about 100,000 cP, at least about 150,000 cP, at least about 200,000 cP, at least about 250,000 cP, or at least about 300,000 cP. In some instances, the paste has a viscosity of at most about 3,000 cP, at most about 6,000 cP, at most about 9,000 cP, at most about 12,000 cP, at most about 15,000 cP, at most about 18,000 cP, at most about 21,000 cP, at most about 24,000 cP, at most about 27,000 cP, at most about 30,000 cP, at most about 50,000 cP, at most about 100,000 cP, at most about 150,000 cP, at most about 200,000 cP, at most about 250,000 cP, or at most about 300,000 cP. Aerosol

[0242] In some instances, the composition to remove metals from hair comprises a chelator composition comprising at least one chelating agent, at least one antioxidant, and at least one anti- redeposition agent, and the composition is formulated as an aerosol.

[0243] In some instances, the aerosol comprises a propellant, a nonionic film-forming polymer, or a combination thereof. In some instances, the propellant comprises propane, butane, isobutane, vinyl chloride, hydrofluorocarbon 152a, or a combination thereof.

[0244] In some instances, to prepare the composition to remove metals from hair as an aerosol, the composition described herein are mixed together along with a propellant, a nonionic film-forming polymer, or a combination thereof and are packaged in an aerosol dispenser such as a can or a mister. Other methods to formulate the composition as an aerosol is known in the art and can be used for the composition described in the present disclosure.

[0245] In some instances, the propellant in the aerosol is present at a concentration of about 0.1% w / w to about 50% w / w of a total weight of the aerosol, about 0.5% w / w to about 50% w / w of a total weight of the aerosol, about 1% w / w to about 50% w / w of a total weight of the aerosol, about 5% w / w to about 50% w / w of a total weight of the aerosol, about 10% w / w to about 50% w / w of a total weight of the aerosol, about 15% w / w to about 50% w / w of a total weight of the aerosol, about 20% w / w to about 50% w / w of a total weight of the aerosol, about 25% w / w to about 50% w / w of a total weight of the aerosol, about 30% w / w to about 50% w / w of a total weight of the aerosol, about 35% w / w to about 50% w / w of a total weight of the aerosol, about 40% w / w to about 50% w / w of a total weight of the aerosol, or about 45% w / w to about 50% w / w of a total weight of the aerosol. In some instances, the propellant in the aerosol is present at a concentration of about 0.1% w / w of a total weight of the aerosol, about 0.5% w / w of a total weight of the aerosol, about 1% w / w of a total weight of the aerosol, about 5% w / w of a total weight of the aerosol, about 10% w / w of a totalAttorney Docket No.63230-732.601 weight of the aerosol, about 15% w / w of a total weight of the aerosol, about 20% w / w of a total weight of the aerosol, about 25% w / w of a total weight of the aerosol, about 30% w / w of a total weight of the aerosol, about 35% w / w of a total weight of the aerosol, about 40% w / w of a total weight of the aerosol, about 45% w / w of a total weight of the aerosol, or about 50% w / w of a total weight of the aerosol. In some instances, the propellant in the aerosol is present at a concentration of at least about 0.1% w / w of a total weight of the aerosol, at least about 0.5% w / w of a total weight of the aerosol, at least about 1% w / w of a total weight of the aerosol, at least about 5% w / w of a total weight of the aerosol, at least about 10% w / w of a total weight of the aerosol, at least about 15% w / w of a total weight of the aerosol, at least about 20% w / w of a total weight of the aerosol, at least about 25% w / w of a total weight of the aerosol, at least about 30% w / w of a total weight of the aerosol, at least about 35% w / w of a total weight of the aerosol, at least about 40% w / w of a total weight of the aerosol, at least about 45% w / w of a total weight of the aerosol, or at least about 50% w / w of a total weight of the aerosol. In some instances, the propellant in the aerosol is present at a concentration of at most about 0.1% w / w of a total weight of the aerosol, at most about 0.5% w / w of a total weight of the aerosol, at most about 1% w / w of a total weight of the aerosol, at most about 5% w / w of a total weight of the aerosol, at most about 10% w / w of a total weight of the aerosol, at most about 15% w / w of a total weight of the aerosol, at most about 20% w / w of a total weight of the aerosol, at most about 25% w / w of a total weight of the aerosol, at most about 30% w / w of a total weight of the aerosol, at most about 35% w / w of a total weight of the aerosol, at most about 40% w / w of a total weight of the aerosol, at most about 45% w / w of a total weight of the aerosol, or at most about 50% w / w of a total weight of the aerosol.

[0246] In some instances, the nonionic film forming polymer comprises a polyalkyloxazoline, a vinyl acetate homopolymer, a vinyl acetate copolymer, a homopolymer of acrylic esters, a copolymer of acrylic esters, a copolymer of acrylonitrile and a nonionic monomer, a styrene homopolymer, a styrene copolymer, a polyamide, a vinylpyrrolidone homopolymer, a copolymer of vinylpyrrolidone and vinyl acetate monomers, a vinyllactam homopolymer (e.g., polyvinylcaprolactam), a vinyllactam copolymer, a poly(vinylpyrrolidone / vinyl acetate / vinyl propionate) terpolymer, or a combination thereof.

[0247] In some instances, the nonionic film forming polymer is present at a concentration of about 0.1% w / w to about 30% w / w of a total weight of the composition. In some instances, the nonionic film forming polymer is present at a concentration of about 0.05% w / w to about 30% w / w of a total weight of the composition, about 0.1% w / wo to about 30% w / w of a total weight of the composition, about 1% w / w to about 30% w / w of the total weight of the composition, about 5% w / w to about 30% w / w of the total weight of the composition, about 10% w / w to about 30% w / w ofAttorney Docket No.63230-732.601 the total weight of the composition, about 15% w / w to about 30% w / w of the total weight of the composition, about 20% w / w to about 30% w / w of the total weight of the composition, or about 25% w / w to about 30% w / w of the total weight of the composition. In some instances, the nonionic film forming polymer is present at a concentration of about 5% w / w to about 20% w / w of the total weight of the composition, about 10% w / w to about 20% w / w of the total weight of the composition, or about 15% w / w to about 20% w / w of the total weight of the composition. In some instances, the nonionic film forming polymer is present at a concentration of about 0.05% w / w of the total weight of the composition, about 0.1% w / w of the total weight of the composition, about 0.5% w / w of the total weight of the composition, about 1% w / w of the total weight of the composition, about 5% w / w of the total weight of the composition, about 10% w / w of the total weight of the composition, about 15% w / w of the total weight of the composition, about 20% w / w of the total weight of the composition, about 25% w / w of the total weight of the composition, or about 30% w / w of the total weight of the composition. In some instances, the nonionic film forming polymer is present at a concentration of at least about 0.05% w / w of the total weight of the composition, at least about 0.1% w / w of the total weight of the composition, at least about 0.5% w / w of the total weight of the composition, at least about 1% w / w of the total weight of the composition, at least about 5% w / w of the total weight of the composition, at least about 10% w / w of the total weight of the composition, at least about 15% w / w of the total weight of the composition, at least about 20% w / w of the total weight of the composition, at least about 25% w / w of the total weight of the composition, or at least about 30% w / w of the total weight of the composition. In some instances, the nonionic film forming polymer is present at a concentration of at most about 0.05% w / w of the total weight of the composition, at most about 0.1% w / w of the total weight of the composition, at most about 0.5% w / w of the total weight of the composition, at most about 1% w / w of the total weight of the composition, at most about 5% w / w of the total weight of the composition, at most about 10% w / w of the total weight of the composition, at most about 15% w / w of the total weight of the composition, at most about 20% w / w of the total weight of the composition, at most about 25% w / w of the total weight of the composition, or at most about 30% w / w of the total weight of the composition.

[0248] In some instances, the aerosol further comprises a plasticizer. In some instances, the plasticizer can promote plasticity or reduce brittleness. In some instances, the plasticizer comprises a citric acid ester, an adipic acid ester, a silicone, a polyglycol, or a combination thereof.

[0249] In some instances, the chelator composition in the aerosol is present at a concentration of about 0.01% w / w to about 30% w / w of a total weight of the aerosol. In some instances, the chelator composition in the aerosol is present at a concentration of about 0.05% w / w to about 30% w / w of aAttorney Docket No.63230-732.601 total weight of the aerosol, about 0.1% w / wo to about 30% w / w of a total weight of the aerosol, about 1% w / w to about 30% w / w of the total weight of the aerosol, about 5% w / w to about 30% w / w of the total weight of the aerosol, about 10% w / w to about 30% w / w of the total weight of the aerosol, about 15% w / w to about 30% w / w of the total weight of the aerosol, about 20% w / w to about 30% w / w of the total weight of the aerosol, or about 25% w / w to about 30% w / w of the total weight of the aerosol. In some instances, the chelator composition in the aerosol is present at a concentration of about 5% w / w to about 20% w / w of the total weight of the aerosol, about 10% w / w to about 20% w / w of the total weight of the aerosol, or about 15% w / w to about 20% w / w of the total weight of the aerosol. In some instances, the chelator composition in the aerosol is present at a concentration of about 0.05% w / w of the total weight of the aerosol, about 0.1% w / w of the total weight of the aerosol, about 0.5% w / w of the total weight of the aerosol, about 1% w / w of the total weight of the aerosol, about 5% w / w of the total weight of the aerosol, about 10% w / w of the total weight of the aerosol, about 15% w / w of the total weight of the aerosol, about 20% w / w of the total weight of the aerosol, about 25% w / w of the total weight of the aerosol, or about 30% w / w of the total weight of the aerosol. In some instances, the chelator composition in the aerosol is present at a concentration of at least about 0.05% w / w of the total weight of the aerosol, at least about 0.1% w / w of the total weight of the aerosol, at least about 0.5% w / w of the total weight of the aerosol, at least about 1% w / w of the total weight of the aerosol, at least about 5% w / w of the total weight of the aerosol, at least about 10% w / w of the total weight of the aerosol, at least about 15% w / w of the total weight of the aerosol, at least about 20% w / w of the total weight of the aerosol, at least about 25% w / w of the total weight of the aerosol, or at least about 30% w / w of the total weight of the aerosol. In some instances, the chelator composition in the aerosol is present at a concentration of at most about 0.05% w / w of the total weight of the aerosol, at most about 0.1% w / w of the total weight of the aerosol, at most about 0.5% w / w of the total weight of the aerosol, at most about 1% w / w of the total weight of the aerosol, at most about 5% w / w of the total weight of the aerosol, at most about 10% w / w of the total weight of the aerosol, at most about 15% w / w of the total weight of the aerosol, at most about 20% w / w of the total weight of the aerosol, at most about 25% w / w of the total weight of the aerosol, or at most about 30% w / w of the total weight of the aerosol. Powder

[0250] In some instances, the composition to remove metals from hair comprises a chelator composition comprising at least one chelating agent, at least one antioxidant, and at least one anti- redeposition agent, and the composition is formulated as a powder.Attorney Docket No.63230-732.601

[0251] In some instances, the powder is prepared by powder-pressing process, milling, or pulverization. Other methods to formulate the composition as a powder is known in the art and can be used for the composition described in the present disclosure.

[0252] In some instances, the powder is a loose powder or a pressed powder. In some instances, the powder is substantially free of water. In some instances, the power comprises a mineral particle. In some instances, the mineral particle is mica, talc, boron nitride, perlite, pumice, alumina, silica, aluminosilicate (e.g., bentonite, kaolin), or a combination thereof.

[0253] In some instances, the powder comprises a filler comprising bulking powder. In some embodiments, a bulking powder is used to dilute other agents or substances, e.g., chelator composition, in the composition to remove metals from hair. In some instances, the bulking powder can add volume to the product to create certain flow or dry texture. In some instances, the filler comprises an organic filler, a non-mineral filler, or a combination thereof. In some instances, the organic filler is polytetrafluoroethylene, polyethylene, e.g., polyethylene beads. In some instances, the non-mineral filler comprises vegetable starches.

[0254] In some instances, the powder is porous. In some instances, the powder is non-porous.

[0255] In some instances, the powder comprises a thermoplastic powder, e.g., polyamide-12, or PECOAT12®.

[0256] In some instances, the powder comprises a saccharide that dissolves upon contact with skin. In some instances, the saccharide that dissolves upon contact with skin comprises cellulose or mannitol.

[0257] In some instances, the powder comprises a spherical organic particle comprising polyethylene, polytetrafluoroethylene (e.g., Teflon®), acrylic copolymers (e.g., ethyleneglycol dimethacrylate / lauryl methacrylate copolymers), silicone resin, polymethyl methacrylate microsphere, ethylene / acrylate copolymer, starch powder (e.g., maize, wheat, rice), fatty acid, polyurethane, carnauba microwax, synthetic wax, or a combination thereof.

[0258] In some instances, the total concentration of the filler in the powder is about 0.1% w / w to about 90% w / w of a total weight of the powder, about 0.5% w / w to about 90% w / w of a total weight of the powder, about 1% w / w to about 90% w / w of a total weight of the powder, about 5% w / w to about 90% w / w of a total weight of the powder, about 10% w / w to about 90% w / w of a total weight of the powder, about 15% w / w to about 90% w / w of a total weight of the powder, about 20% w / w to about 90% w / w of a total weight of the powder, about 25% w / w to about 90% w / w of a total weight of the powder, about 30% w / w to about 90% w / w of a total weight of the powder, about 35% w / w to about 90% w / w of a total weight of the powder, about 40% w / w to about 90% w / w of a total weight of the powder, about 45% w / w to about 90% w / w of a total weight of theAttorney Docket No.63230-732.601 powder, about 50% w / w to about 90% w / w of a total weight of the powder, about 55% w / w to about 90% w / w of a total weight of the powder, about 60% w / w to about 90% w / w of a total weight of the powder, about 65% w / w to about 90% w / w of a total weight of the powder, about 70% w / w to about 90% w / w of a total weight of the powder, about 75% w / w to about 90% w / w of a total weight of the powder, about 80% w / w to about 90% w / w of a total weight of the powder, or about 85% w / w to about 90% w / w of a total weight of the powder. In some instances, the total concentration of the filler in the powder is about 0.1% w / w of a total weight of the powder, about 0.5% w / w of a total weight of the powder, about 1% w / w of a total weight of the powder, about 5% w / w of a total weight of the powder, about 10% w / w of a total weight of the powder, about 15% w / w of a total weight of the powder, about 20% w / w of a total weight of the powder, about 25% w / w of a total weight of the powder, about 30% w / w of a total weight of the powder, about 35% w / w of a total weight of the powder, about 40% w / w of a total weight of the powder, about 45% w / w of a total weight of the powder, about 50% w / w of a total weight of the powder, about 55% w / w of a total weight of the powder, about 60% w / w of a total weight of the powder, about 65% w / w of a total weight of the powder, about 70% w / w of a total weight of the powder, about 75% w / w of a total weight of the powder, about 80% w / w of a total weight of the powder, about 85% w / w of a total weight of the powder, or about 90% w / w of a total weight of the powder. In some instances, the total concentration of the filler in the powder is at least about 0.1% w / w of a total weight of the powder, at least about 0.5% w / w of a total weight of the powder, at least about 1% w / w of a total weight of the powder, at least about 5% w / w of a total weight of the powder, at least about 10% w / w of a total weight of the powder, at least about 15% w / w of a total weight of the powder, at least about 20% w / w of a total weight of the powder, at least about 25% w / w of a total weight of the powder, at least about 30% w / w of a total weight of the powder, at least about 35% w / w of a total weight of the powder, at least about 40% w / w of a total weight of the powder, at least about 45% w / w of a total weight of the powder, at least about 50% w / w of a total weight of the powder, at least about 55% w / w of a total weight of the powder, at least about 60% w / w of a total weight of the powder, at least about 65% w / w of a total weight of the powder, at least about 70% w / w of a total weight of the powder, at least about 75% w / w of a total weight of the powder, at least about 80% w / w of a total weight of the powder, at least about 85% w / w of a total weight of the powder, or at least about 90% w / w of a total weight of the powder. In some instances, the total concentration of the filler in the powder is at most about 0.1% w / w of a total weight of the powder, at most about 0.5% w / w of a total weight of the powder, at most about 1% w / w of a total weight of the powder, at most about 5% w / w of a total weight of the powder, at most about 10% w / w of a total weight of the powder, at most about 15% w / w of a total weight of the powder, at most aboutAttorney Docket No.63230-732.601 20% w / w of a total weight of the powder, at most about 25% w / w of a total weight of the powder, at most about 30% w / w of a total weight of the powder, at most about 35% w / w of a total weight of the powder, at most about 40% w / w of a total weight of the powder, at most about 45% w / w of a total weight of the powder, at most about 50% w / w of a total weight of the powder, at most about 55% w / w of a total weight of the powder, at most about 60% w / w of a total weight of the powder, at most about 65% w / w of a total weight of the powder, at most about 70% w / w of a total weight of the powder, at most about 75% w / w of a total weight of the powder, at most about 80% w / w of a total weight of the powder, at most about 85% w / w of a total weight of the powder, or at most about 90% w / w of a total weight of the powder.

[0259] In some instances, the total concentration of the mineral particle in the powder is about 0.1% w / w to about 90% w / w of a total weight of the powder, about 0.5% w / w to about 90% w / w of a total weight of the powder, about 1% w / w to about 90% w / w of a total weight of the powder, about 5% w / w to about 90% w / w of a total weight of the powder, about 10% w / w to about 90% w / w of a total weight of the powder, about 15% w / w to about 90% w / w of a total weight of the powder, about 20% w / w to about 90% w / w of a total weight of the powder, about 25% w / w to about 90% w / w of a total weight of the powder, about 30% w / w to about 90% w / w of a total weight of the powder, about 35% w / w to about 90% w / w of a total weight of the powder, about 40% w / w to about 90% w / w of a total weight of the powder, about 45% w / w to about 90% w / w of a total weight of the powder, about 50% w / w to about 90% w / w of a total weight of the powder, about 55% w / w to about 90% w / w of a total weight of the powder, about 60% w / w to about 90% w / w of a total weight of the powder, about 65% w / w to about 90% w / w of a total weight of the powder, about 70% w / w to about 90% w / w of a total weight of the powder, about 75% w / w to about 90% w / w of a total weight of the powder, about 80% w / w to about 90% w / w of a total weight of the powder, or about 85% w / w to about 90% w / w of a total weight of the powder. In some instances, the total concentration of the mineral particle in the powder is about 0.1% w / w of a total weight of the powder, about 0.5% w / w of a total weight of the powder, about 1% w / w of a total weight of the powder, about 5% w / w of a total weight of the powder, about 10% w / w of a total weight of the powder, about 15% w / w of a total weight of the powder, about 20% w / w of a total weight of the powder, about 25% w / w of a total weight of the powder, about 30% w / w of a total weight of the powder, about 35% w / w of a total weight of the powder, about 40% w / w of a total weight of the powder, about 45% w / w of a total weight of the powder, about 50% w / w of a total weight of the powder, about 55% w / w of a total weight of the powder, about 60% w / w of a total weight of the powder, about 65% w / w of a total weight of the powder, about 70% w / w of a total weight of the powder, about 75% w / w of a total weight of the powder, about 80% w / w of a total weight of theAttorney Docket No.63230-732.601 powder, about 85% w / w of a total weight of the powder, or about 90% w / w of a total weight of the powder. In some instances, the total concentration of the mineral particle in the powder is at least about 0.1% w / w of a total weight of the powder, at least about 0.5% w / w of a total weight of the powder, at least about 1% w / w of a total weight of the powder, at least about 5% w / w of a total weight of the powder, at least about 10% w / w of a total weight of the powder, at least about 15% w / w of a total weight of the powder, at least about 20% w / w of a total weight of the powder, at least about 25% w / w of a total weight of the powder, at least about 30% w / w of a total weight of the powder, at least about 35% w / w of a total weight of the powder, at least about 40% w / w of a total weight of the powder, at least about 45% w / w of a total weight of the powder, at least about 50% w / w of a total weight of the powder, at least about 55% w / w of a total weight of the powder, at least about 60% w / w of a total weight of the powder, at least about 65% w / w of a total weight of the powder, at least about 70% w / w of a total weight of the powder, at least about 75% w / w of a total weight of the powder, at least about 80% w / w of a total weight of the powder, at least about 85% w / w of a total weight of the powder, or at least about 90% w / w of a total weight of the powder. In some instances, the total concentration of the mineral particle in the powder is at most about 0.1% w / w of a total weight of the powder, at most about 0.5% w / w of a total weight of the powder, at most about 1% w / w of a total weight of the powder, at most about 5% w / w of a total weight of the powder, at most about 10% w / w of a total weight of the powder, at most about 15% w / w of a total weight of the powder, at most about 20% w / w of a total weight of the powder, at most about 25% w / w of a total weight of the powder, at most about 30% w / w of a total weight of the powder, at most about 35% w / w of a total weight of the powder, at most about 40% w / w of a total weight of the powder, at most about 45% w / w of a total weight of the powder, at most about 50% w / w of a total weight of the powder, at most about 55% w / w of a total weight of the powder, at most about 60% w / w of a total weight of the powder, at most about 65% w / w of a total weight of the powder, at most about 70% w / w of a total weight of the powder, at most about 75% w / w of a total weight of the powder, at most about 80% w / w of a total weight of the powder, at most about 85% w / w of a total weight of the powder, or at most about 90% w / w of a total weight of the powder.

[0260] In some instances, the total concentration of the filler and mineral particle in the powder is about 0.1% w / w to about 90% w / w of a total weight of the powder, about 0.5% w / w to about 90% w / w of a total weight of the powder, about 1% w / w to about 90% w / w of a total weight of the powder, about 5% w / w to about 90% w / w of a total weight of the powder, about 10% w / w to about 90% w / w of a total weight of the powder, about 15% w / w to about 90% w / w of a total weight of the powder, about 20% w / w to about 90% w / w of a total weight of the powder, about 25% w / w toAttorney Docket No.63230-732.601 about 90% w / w of a total weight of the powder, about 30% w / w to about 90% w / w of a total weight of the powder, about 35% w / w to about 90% w / w of a total weight of the powder, about 40% w / w to about 90% w / w of a total weight of the powder, about 45% w / w to about 90% w / w of a total weight of the powder, about 50% w / w to about 90% w / w of a total weight of the powder, about 55% w / w to about 90% w / w of a total weight of the powder, about 60% w / w to about 90% w / w of a total weight of the powder, about 65% w / w to about 90% w / w of a total weight of the powder, about 70% w / w to about 90% w / w of a total weight of the powder, about 75% w / w to about 90% w / w of a total weight of the powder, about 80% w / w to about 90% w / w of a total weight of the powder, or about 85% w / w to about 90% w / w of a total weight of the powder. In some instances, the total concentration of the filler and mineral particle in the powder is about 0.1% w / w of a total weight of the powder, about 0.5% w / w of a total weight of the powder, about 1% w / w of a total weight of the powder, about 5% w / w of a total weight of the powder, about 10% w / w of a total weight of the powder, about 15% w / w of a total weight of the powder, about 20% w / w of a total weight of the powder, about 25% w / w of a total weight of the powder, about 30% w / w of a total weight of the powder, about 35% w / w of a total weight of the powder, about 40% w / w of a total weight of the powder, about 45% w / w of a total weight of the powder, about 50% w / w of a total weight of the powder, about 55% w / w of a total weight of the powder, about 60% w / w of a total weight of the powder, about 65% w / w of a total weight of the powder, about 70% w / w of a total weight of the powder, about 75% w / w of a total weight of the powder, about 80% w / w of a total weight of the powder, about 85% w / w of a total weight of the powder, or about 90% w / w of a total weight of the powder. In some instances, the total concentration of the filler and mineral particle in the powder is at least about 0.1% w / w of a total weight of the powder, at least about 0.5% w / w of a total weight of the powder, at least about 1% w / w of a total weight of the powder, at least about 5% w / w of a total weight of the powder, at least about 10% w / w of a total weight of the powder, at least about 15% w / w of a total weight of the powder, at least about 20% w / w of a total weight of the powder, at least about 25% w / w of a total weight of the powder, at least about 30% w / w of a total weight of the powder, at least about 35% w / w of a total weight of the powder, at least about 40% w / w of a total weight of the powder, at least about 45% w / w of a total weight of the powder, at least about 50% w / w of a total weight of the powder, at least about 55% w / w of a total weight of the powder, at least about 60% w / w of a total weight of the powder, at least about 65% w / w of a total weight of the powder, at least about 70% w / w of a total weight of the powder, at least about 75% w / w of a total weight of the powder, at least about 80% w / w of a total weight of the powder, at least about 85% w / w of a total weight of the powder, or at least about 90% w / w of a total weight of the powder. In some instances, the total concentration of the filler and mineral particle in theAttorney Docket No.63230-732.601 powder is at most about 0.1% w / w of a total weight of the powder, at most about 0.5% w / w of a total weight of the powder, at most about 1% w / w of a total weight of the powder, at most about 5% w / w of a total weight of the powder, at most about 10% w / w of a total weight of the powder, at most about 15% w / w of a total weight of the powder, at most about 20% w / w of a total weight of the powder, at most about 25% w / w of a total weight of the powder, at most about 30% w / w of a total weight of the powder, at most about 35% w / w of a total weight of the powder, at most about 40% w / w of a total weight of the powder, at most about 45% w / w of a total weight of the powder, at most about 50% w / w of a total weight of the powder, at most about 55% w / w of a total weight of the powder, at most about 60% w / w of a total weight of the powder, at most about 65% w / w of a total weight of the powder, at most about 70% w / w of a total weight of the powder, at most about 75% w / w of a total weight of the powder, at most about 80% w / w of a total weight of the powder, at most about 85% w / w of a total weight of the powder, or at most about 90% w / w of a total weight of the powder.

[0261] In some instances, the chelator composition in the powder is present at a concentration of about 10% w / w to about 90% w / w of a total weight of the powder. In some instances, the chelator composition in the powder is present at a concentration of about 0.05% w / w to about 30% w / w of a total weight of the powder, about 0.1% w / w to about 30% w / w of a total weight of the powder, about 1% w / w to about 30% w / w of the total weight of the powder, about 5% w / w to about 30% w / w of the total weight of the powder, about 10% w / w to about 30% w / w of the total weight of the powder, about 15% w / w to about 30% w / w of the total weight of the powder, about 20% w / w to about 30% w / w of the total weight of the powder, or about 25% w / w to about 30% w / w of the total weight of the powder. In some instances, the chelator composition in the powder is present at a concentration of about 5% w / w to about 20% w / w of the total weight of the powder, about 10% w / w to about 20% w / w of the total weight of the powder, or about 15% w / w to about 20% w / w of the total weight of the powder. In some instances, the chelator composition in the powder is present at a concentration of about 0.05% w / w of the total weight of the powder, about 0.1% w / w of the total weight of the powder, about 0.5% w / w of the total weight of the powder, about 1% w / w of the total weight of the powder, about 5% w / w of the total weight of the powder, about 10% w / w of the total weight of the powder, about 15% w / w of the total weight of the powder, about 20% w / w of the total weight of the powder, about 25% w / w of the total weight of the powder, or about 30% w / w of the total weight of the powder. In some instances, the chelator composition in the powder is present at a concentration of at least about 0.05% w / w of the total weight of the powder, at least about 0.1% w / w of the total weight of the powder, at least about 0.5% w / w of the total weight of the powder, at least about 1% w / w of the total weight of the powder, at least about 5% w / w of theAttorney Docket No.63230-732.601 total weight of the powder, at least about 10% w / w of the total weight of the powder, at least about 15% w / w of the total weight of the powder, at least about 20% w / w of the total weight of the powder, at least about 25% w / w of the total weight of the powder, or at least about 30% w / w of the total weight of the powder. In some instances, the chelator composition in the powder is present at a concentration of at most about 0.05% w / w of the total weight of the p...

Claims

Attorney Docket No.63230-732.601 CLAIMS WHAT IS CLAIMED IS:

1. A composition for removing a metal from hair, comprising: a chelator composition comprising at least one chelating agent comprising trisodium dicarboxymethyl alaninate (trisodium MGDA), sodium phytate, sodium gluconate, tetrasodium glutamate diacetate, tetrasodium glutamate diacetate (tetrasodium GLDA), pentasodium pentetate, trisodium ethylenediamine succinate, sodium thiosulfate, caprylhydroxamic acid, diiospropyl oxalate, oxalic acid, potassium citrate, sodium citrate, or sodium oxalate, or a combination of two or more thereof; and at least one foaming agent; wherein the composition removes one or more metals from solution or hair of a subject.

2. The composition of claim 1, wherein the at least one chelating agent binds to a primary metal, a secondary metal, or a combination thereof.

3. The composition of claim 1 or claim 2, wherein the at least one chelating agent binds a metal comprising calcium (Ca), magnesium (Mg), copper (Cu), iron (Fe), chromium (Cr), nickel (Ni), aluminum (Al), lead (Pb), zinc (Zn), cadmium (Cd), mercury (Hg), arsenic (As), barium (Ba), cobalt (Co), manganese (Mn), tin (Sn), tungsten (W), antimony (Sb), beryllium (Be), boron (B), bismuth (Bi), cesium (Ce), lithium (Li), molybdenum (Mo), selenium (Se), strontium (Sr), thallium (Tl), titanium (Ti), vanadium (V), scandium (Sc), gallium (Ga), yttrium (Y), niobium (Nb), technetium (Tc), ruthenium (Ru), rhodium (Rh), palladium (Pd), indium (In), tellurium (Te), rhenium (Rh), osmium (Os), iridium (Ir), or a combination thereof.

4. The composition of any one of claims 1-3, wherein the at least one chelating agent binds a metal selected from the group consisting of: calcium, magnesium, copper, iron, chromium, nickel, aluminum, lead, zinc, cadmium, mercury, arsenic, or a combination thereof.

5. The composition of any one of claims 1-4, wherein the chelator composition comprises at least 3 chelating agents.Attorney Docket No.63230-732.601 6. The composition of any one of claims 1-5, wherein the chelator composition comprises at least 4 chelating agents.

7. The composition of any one of claims 1-6, wherein the at least one chelating agent comprises trisodium dicarboxymethyl alaninate (trisodium MGDA), sodium phytate, phytic acid, sodium gluconate, tetrasodium glutamate diacetate (tetrasodium GLDA), pentasodium pentetate, trisodium ethylenediamine succinate, sodium thiosulfate, caprylhydroxamic acid, diisopropyl oxalate, oxalic acid, potassium citrate, sodium citrate, or sodium oxalate, or a combination thereof.

8. The composition of any one of claims 1-7, wherein the at least one chelating agent comprises trisodium MGDA, sodium phytate, sodium gluconate, tetrasodium GLDA, diisopropyl oxalate, oxalic acid, potassium citrate, or a combination thereof.

9. The composition of any one of claims 1-8, wherein the chelator composition is substantially free of ethylenediaminetetraacetic acid (EDTA).

10. The composition of any one of claims 1-9, wherein the composition is formulated as a foam.

11. The composition of claim 10, wherein the foaming agent comprises a surfactant, a copolymer, or a combination thereof.

12. The composition of claim 11, wherein the surfactant is an anionic surfactant, an amphoteric surfactant, a nonionic surfactant, or a combination thereof.

13. The composition of claim 12, wherein the anionic surfactant comprises sodium methyl 2-sulfolaurate, sodium lauryl sulfoacetate, disodium 2-sulfolaurate, alkylbenzene sulfonates, ammonium lauryl sulfate, ammonium xylenesulfonate, sodium laureth sulfate, sodium lauryl sulfate, sodium lauryl sulfoacetate, sodium 2-sulfolaurate, sodium myreth sulfate, sodium xylenesulfonate, sodium C14-16 olefin sulfonate, sodium C14-16 alpha olefin sulfonate, disodium lauryl sulfosuccinate, sodium methyl cocoyl taurate, sodium cocoyl isethionate, sodium lauryl isethionate, sodium cocoyl sarcosinate, sodium lauroylAttorney Docket No.63230-732.601 sarcosinate, sodium myristoyl sarcosinate, lauroyl sarcosine, cocoyl sarcosine, myristoyl sarcosine, oleoyl sarcosine, myristoyl / stearoyl sarcosine, sodium lauroyl glutamate, sodium cocoyl glutamate, disodium cocoyl glutamate, cocoyl glutamic acid, lauroyl glutamic acid, potassium cocoyl glutamate, potassium lauroyl glutamate, potassium myristoyl glutamate, sodium myristoyl glutamate, sodium stearoyl glutamate, disodium stearoyl glutamate, sodium palmitoyl glutamate, sodium lauroyl lactylate, sodium astrocaryum murumuruate, sodium laurylglucoside hydroxypropylsulfonate, disodium laurylglucoside hydroxypropyl citrate, sodium hydroxypropylsulfonate laurylglucoside crosspolymer, dioctyl sodium sulfosuccinate, or a combination thereof.

14. The composition of claim 12 or claim 13, wherein the amphoteric surfactant comprises cocamidopropyl hydroxysultaine, cocamidopropyl betaine, coco betaine, betaine, cocoamphoacetate, cocoamphodipropionate, disodium cocoamphodiacetate, disodium cocoamphodipropionate, lauryl betaine, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium dilauramidoglutamide lysine, sodium cocoamphopropionate, lauroamphoacetate, or a combination thereof.

15. The composition of any one of claims 12-14, wherein the nonionic surfactant is decyl glucoside, lauryl glucoside, coco-glucoside, cocoyl methyl glucamide, capryloyl / caproyl methyl glucamide, lauroyl / myristoyl methyl glucamide, cocamidopropylamine oxide, decylamine oxide, or a combination thereof.

16. The composition of any one of claims 11-15, wherein the total concentration of the surfactant in the composition is about 0.1% (w / w) to about 90% (w / w), about 0.1% (w / w) to about 80% (w / w), about 0.1% (w / w) to about 70% (w / w), about 0.1% (w / w) to about 60% (w / w), about 0.1% (w / w) to about 50% (w / w), about 0.1% (w / w) to about 40% (w / w), or about 0.1% (w / w) to about 30% (w / w) of a total weight of the composition.

17. The composition of any one of claims 11-16, wherein the total concentration of the surfactant in the foam is about 1% (w / w) to about 30% (w / w) of the total weight of the composition.Attorney Docket No.63230-732.601 18. The composition of any one of claims 11-17, wherein the total concentration of the surfactant in the composition is about 5% (w / w) to about 20% (w / w) of the total weight of the composition.

19. The composition of any one of claims 13-18, wherein the anionic surfactant has a net negative charge at a pH of about 4 to about 9.

20. The composition of any one of claims 14-19, wherein the cationic surfactant has a net positive charge at a pH of about 4 to about 9.

21. The composition of any one of claims 11-20, wherein the surfactant comprises benzethonium chloride, betaine, cocamide diethanolamine, cocamidopropyl betaine, cocamidopropyl betaine (CAPB), cocamidopropyl hydroxysultaine, cocamidopropylamine oxide, coco-glucoside, decyl glucoside, decylamine oxide, dimyristoyl phosphatidylcholine, dipalmitoyl phosphatidylcholine, disodium cocoamphodiacetate, distearoyl phosphatidylcholine, hydrogenated starch hydrolysate, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauroyl sarcosine, lauryl betaine, lauryl glucoside, lauryl hydroxysultaine, maltooligosyl glucoside, potassium cocoyl hydrolyzed oat protein, sodium C14-16alpha olefin sulfonate, sodium C14-16olefin sulfonate, sodium cocoyl isethionate, sodium lauroyl glutamate, sodium lauroyl isethionate, sodium lauroyl sarcosinate, sodium methyl cocoyl taurate, sucrose glucoside, caprylyl / capryl glucoside, Starmella bombicola / brassica oil ferment, Sapindus mukorossi peel extract, sophorolipid, coconut extract, palm kernel extract, or a combination thereof.

22. The composition of any one of claims 11-21, wherein the surfactant comprises a sophorolipid, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium lauroyl sarcosinate, sodium lauroyl isethionate, sodium cocoyl isethionate, lauroyl sarcosine, sodium lauroyl glutamate, sodium methyl cocoyl taurate, disodium cocoamphodiacetate, sodium C14-16 olefin sulfonate, sodium C14-16 alpha olefin sulfonate, cocamide diethanolamine, cocamidopropyl betaine (CAPB), cocobetaine, betaine, lauryl betaine, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, cocamidopropyl hydroxysultaine, dipalmitoyl phosphatidylcholine, dimyristoyl phosphatidylcholine, distearoyl phosphatidylcholine, or a combination thereof.Attorney Docket No.63230-732.601 23. The composition of any one of claims 11-22, wherein the surfactant comprises a saccharide comprising decyl glucoside, lauryl glucoside, coco-glucoside, maltooligosyl glucoside, hydrogenated starch hydrolysate, or a combination thereof.

24. The composition of any one of claims 11-23, wherein the surfactant is selected from the group of Sapindus mukorossi peel extract, potassium cocoyl hydrolyzed oat protein, Starmella bombicola / brassica oil ferment, lauramidopropyl hydroxysultaine, lauryl hydroxysultaine, sodium lauroyl sarcosinate, sodium lauroyl isethionate, sodium cocoyl isethionate, lauroyl sarcosine, sodium lauroyl glutamate, sodium methyl cocoyl taurate, disodium cocoamphodiacetate, sodium C14-16olefin sulfonate, sodium C14-16alpha olefin sulfonate, benzethonium chloride, cocamidopropylamine oxide, decylamine oxide, decyl glucoside, lauryl glucoside, coco-glucoside, cocamidopropyl betaine, betaine, lauryl betaine, lauramidopropyl hydroxysultaine, cocamidopropyl hydroxysultaine, maltooligosyl glucoside, hydrogenated starch hydrolysate, or a combination thereof.

25. The composition of any one of claims 11-24, wherein the surfactant comprises polysorbate 20, polyglyceryl-10 laurate, polyglyceryl-6 caprylate, polyglyceryl-3 cocoate, polyglyceryl-4 caprate, polyglyceryl-6 ricinoleate, polyglyceryl-6 caprylate, sodium surfactin, or a combination thereof.

26. The composition of any one of claims 11-25, wherein the surfactant is present at a concentration of about 0.5% (w / w) to about 20% (w / w) of a total weight of the composition.

27. The composition of any one of claims 11-26, wherein the composition comprises a first surfactant and a second surfactant.

28. The composition of claim 27, wherein the first surfactant comprises Starmella bombicola / brassica oil ferment, Sapindus mukorossi peel extract, sophorolipid, coconut extract, or palm kernel extract, or a combination thereof.

29. The composition of claim 27 or claim 28, wherein the second surfactant comprises benzethonium chloride, betaine, cocamide diethanolamine, cocamidopropyl betaine, cocamidopropyl betaine (CAPB), cocamidopropyl hydroxysultaine, cocamidopropylamine oxide, coco-glucoside, decyl glucoside, decylamine oxide, dimyristoyl phosphatidylcholine,Attorney Docket No.63230-732.601 dipalmitoyl phosphatidylcholine, disodium cocoamphodiacetate, distearoyl phosphatidylcholine, hydrogenated starch hydrolysate, lauramidopropyl betaine, lauramidopropyl hydroxysultaine, lauroyl sarcosine, lauryl betaine, lauryl glucoside, lauryl hydroxysultaine, maltooligosyl glucoside, potassium cocoyl hydrolyzed oat protein, sodium C14-16alpha olefin sulfonate, sodium C14-16olefin sulfonate, sodium cocoyl isethionate, sodium lauroyl glutamate, sodium lauroyl isethionate, sodium lauroyl sarcosinate, sodium methyl cocoyl taurate, sucrose glucoside, or caprylyl / capryl glucoside, or a combination thereof.

30. The composition of any one of claims 27-29, wherein the first surfactant is present at a concentration of about 0.5% (w / w) to about 5% (w / w) of a total weight of the composition.

31. The composition of any one of claims 27-30, wherein the second surfactant is present at a concentration of about 5% (w / w) to about 20% (w / w) of a total weight of the composition.

32. The composition of any one of claims 27-31, wherein the first surfactant and the second surfactant are present in a mass ratio of about 1:1, about 1:2, about 1:3, about 1:4, about 1:5, about 1:10, about 1:15, about 1:20, about 1:25, about 1:30, about 1:35 or about 1:

40.

33. The composition of any one of claims 1-32, comprising an anti-redeposition agent comprises an anionic functionalized biopolymer having sequestering capacity.

34. The composition of claim 33, wherein the anti-redeposition agent forms a layer adjacent to a hair.

35. The composition of claim 33 or claim 34, wherein the at least one anti-redeposition agent comprises a polymer, or a silicate, or a combination thereof, wherein the polymer comprises a polypeptide, a polyacrylamide, a polyacrylamide / acrylamidopropyltrimonium copolymer, a polyquaternium, a polysaccharide, or a combination thereof.

36. The composition of claim 35, wherein the polypeptide comprises polyaspartate, polyglutamate, polyalanine, polyserine, polyarginine, or polylysine, or a combination thereof.Attorney Docket No.63230-732.601 37. The composition of claim 35, wherein the polyquaternium comprises polyquaternium-2, polyquaternium-4, polyquaternium-7, polyquaternium-10, polyquaternium-17, polyquaternium-18, polyquaternium-24, polyquaternium-27, polyquaternium-28, polyquaternium-32, polyquaternium,-33, polyquaternium-37, polyquaternium-55, polyquaternium-60, or polyquaternium-113, or a combination thereof.

38. The composition of claim 35, wherein the polysaccharide comprises sodium carboxymethyl inulin, xanthan gum, hydroxyethylcellulose, hydroxymethylcellulose, cellulose, cellulose gum, microcrystalline cellulose, carboxymethylcellulose, pullulan, sclerotium gum, tetragonoloba (guar) gum, acacia senegal gum, hydroxypropyl starch phosphate, or a combination thereof.

39. The composition of any one of claims 35-38, wherein the silicate comprises lithium magnesium sodium silicate, sodium magnesium fluorosilicate, magnesium aluminum silicate, or a combination thereof.

40. The composition of any one of claims 33-39, wherein the at least one anti- redeposition agent comprises a polyacrylamide / acrylamidopropyltrimonium copolymer, polyaspartate, polyglutamate, polyalanine, polyserine, polyarginine, polylysine, polyquaternium-2, polyquaternium-4, polyquaternium-7, polyquaternium-10, polyquaternium-17, polyquaternium-18, polyquaternium-24, polyquaternium-27, polyquaternium-28, polyquaternium-32, polyquaternium,-33, polyquaternium-37, polyquaternium-55, polyquaternium-60, or polyquaternium-113, sodium carboxymethyl inulin, xanthan gum, hydroxyethylcellulose, hydroxymethylcellulose, cellulose, cellulose gum, microcrystalline cellulose, carboxymethylcellulose, pullulan, sclerotium gum, tetragonoloba (guar) gum, acacia senegal gum, hydroxypropyl starch phosphate, lithium magnesium sodium silicate, sodium magnesium fluorosilicate, or a combination thereof.

41. The composition of any one of claims 33-40, wherein the anti-redeposition agent is present at a concentration of about 1% (w / w) to about 5% (w / w) of a total weight of the composition.

42. The composition of any one of claims 33-41, wherein the anti-redeposition agent and the chelator composition are present in a mass ratio of about 1:2, about 1:5, about 1:10,Attorney Docket No.63230-732.601 about 1.5:2, about 1.5: 2.1, about 1.5: 2.2, about 1.5:2.3, about 1.5:2.4, about 1.5:2.5, about 1.5:2.6, about 1.5:2.7, about 1.5:2.8, about 1.5: 2.9, about 2:2.1, about 2:2.2, about 2:2.3, about 2:2.4, about 2:2.5, about 2:2.6, about 2:2.7, about 2:2.8, about 2:2.9, about 2:3, or about 2:

5.

43. The composition of any one of claims 1-42, wherein the composition further comprises a toning dye.

44. The composition of claim 43, wherein the toning dye comprises a purple dye, a blue dye, a green dye, a red dye, a yellow dye, an orange dye, or a combination thereof.

45. The composition of claim 43 or claim 44, wherein the toning dye is present at a concentration of about 0.1% (w / w) to about 20% (w / w) of a total weight of the composition.

46. The composition of any one of claims 1-45, wherein the composition comprises an antioxidant.

47. The composition of claim 46, wherein the antioxidant comprises carnosine, valine- cysteine, di-proline, di-phenylalanine, tocopherol, ascorbate, or a combination thereof.

48. The composition of claim 46 or claim 47, wherein the at least one antioxidant comprises carnosine, ascorbic acid, tetrahexyldecyl ascorbate, bioflavonoids, lycopene, Daucus carota sativa root cell culture lysate, monoammonium glycyrrhizinate, alpha lipoic acid (thioctic acid), Leontopodium alpinum (edelweiss) extract, Rosmarinus officinalis (rosemary) leaf extract, Vitis vinifera (grape) seed extract, Camellia sinensis leaf extract, Quercus robur wood extract, hydrolyzed olive fruit, Olea europea (olive) leaf extract, oleuropein, Punica granatum bark / fruit extract, punicalagin, ellagic acid, polyphenols, epigallocatechin (EGCG), tannins, sulforaphane, resveratrol, nordihydroguaiaretic acid, thioctic acid, or a combination thereof.

49. The composition of any one of claims 46-48, wherein the total concentration (%w / w) of the at least one antioxidant in the composition is about 0.1% (w / w) to about 10% (w / w) of a total weight of the composition.Attorney Docket No.63230-732.601 50. The composition of any one of claims 1-49, wherein the composition has a pH of about 5 to about 9.

51. The composition of any one of claims 1-50, wherein the composition has a pH of about 7 to about 8.

52. The composition of any one of claims 1-50, wherein the composition has a pH of about 5 to about 6.

53. The composition of any one of claims 1-52, further comprising at least one pH modifier.

54. The composition of claim 53, wherein the at least one pH modifier comprises lactic acid, citric acid, malic acid, gluconic acid, glucuronic acid, glycolic acid, tartaric acid, azelaic acid, acetic acid, triethanolamine, L-arginine, or a conjugate base thereof, or a combination thereof.

55. The composition of any one of claims 52-54, wherein the at least one pH modifier further comprises potassium hydroxide, sodium hydroxide, or both.

56. The composition of any one of claims 52-55, wherein the at least one pH modifier has a pKaof about 4.0 to about 10.

0.

57. The composition of any one of claims 52-56, wherein the total concentration (%w / w) of the at least one pH modifier in the composition is about 0.1% (w / w) to about 1% (w / w) of a total weight of the composition.

58. The composition of any one of claims 1-57, further comprising at least one solvent.

59. The composition of claim 58, wherein the at least one solvent comprises a polar aprotic solvent, a polar protic solvent, a halocarbon solvent, or a combination thereof.Attorney Docket No.63230-732.601 60. The composition of claim 59, wherein the polar aprotic solvent is dimethyl isosorbide, 1-methyl-2-pyrrolidone, 1-ethylpyrrolidin-2-one, N,N-dimethylacetamide, N-N- dimethylformamide (DMF), or a combination thereof.

61. The composition of claim 60, wherein the polar protic solvent comprises water, alcohol, glycol, or a combination thereof.

62. The composition of claim 61, wherein the alcohol comprises methanol, ethanol, propanol, isopropanol, isobutanol, triethyl citrate, or pantothenyl alcohol.

63. The composition of claim 61, wherein the glycol is ethylene glycol, propane-1,2- glycol, propane-1,3-glycol, or a combination thereof.

64. The composition of claim 59, wherein the halocarbon solvent comprises chlorotrifluoropropene.

65. The composition of any one of claims 1-64, further comprising at least one cosmetically or dermatologically acceptable excipient, wherein the at least one dermatologically acceptable excipient comprises a detoxifying agent, a suspending agent, a perfume, a preservative, or a combination thereof.

66. The composition of claim 65, wherein the detoxifying agent comprises a clay, an acid, or a combination thereof.

67. The composition of claim 65 or claim 66, wherein the detoxifying agent comprises charcoal, bentonite clay, diatomite clay, kaolin clay, salicylic acid, ascorbic acid, glycolic acid, or a combination thereof.

68. The composition of any one of claims 65-71, wherein the suspending agent comprises an anionic polymer, nonionic polymer, or a combination thereof.

69. The composition of any one of claims 65-68, wherein the suspending agent comprises carbomer, methyl cellulose, ethyl cellulose, nitrocellulose, sodium carboxymethyl cellulose, crystalline cellulose, cellulose powder, polyvinylpyrrolidone,Attorney Docket No.63230-732.601 polyvinyl alcohol, guar gum, hydroxypropyl guar gum, arabia gum, galactan, carob gum, pectin, agar, quince seed (Cydonia oblonga Mill), starch (rice, corn, potato, wheat), algae colloid (algae extract), dextran, succinoglucan, pulleran, carboxymethyl starch, methylhydroxypropyl starch, sodium alginate, alginic acid propylene glycol ester, sodium polyacrylate, polyethylacrylate, polyacrylamide, polyethyleneimine, bentonite, aluminum magnesium silicate, laponite, hectonite, anhydrous silicic acid, or a combination thereof.

70. The composition of any one of claims 65-69, wherein the detoxifying agent is present at a concentration (% w / w) of about 0.1% (w / w) to about 1% (w / w) of a total weight of the composition.

71. The composition of any one of claims 65-70, wherein the suspending agent is present at a concentration (% w / w) of about 0.1% (w / w) to about 1% (w / w) of a total weight of the composition.

72. The composition of any one of claims 1-71, comprising a thickening agent.

73. The composition of claim 72, wherein the thickening agent increases a viscosity of the composition when dispersed or dissolved in water or a water-soluble solvent.

74. The composition of claim 72 or claim 73, wherein the thickening agent comprises a carboxylic acid polymer, a crosslinked polyacrylate polymer, a polyacrylamide polymer, a polysaccharide, a gum, or a combination thereof.

75. The composition of claim 74, wherein the carboxylic acid polymer comprises a carbomer, acrylic acid, substituted acrylic acid, or a salt or ester thereof, each monomer of the carboxylic acid polymer is connected via a double bond.

76. The composition of claim 74, wherein the polysaccharide comprises an alkyl- substituted cellulose comprising methylcellulose, a hydroxyethylcellulose, a carboxymethylcellulose, or an acylated derivative thereof, or a combination thereof.

77. The composition of claim 74, wherein the gum comprises acacia, agar, algin, alginic acid, ammonium alginate, amylopectin, calcium alginate, calcium carrageenan,Attorney Docket No.63230-732.601 carnitine, carrageenan, dextrin, gelatin, gellan gum, guar gum, guar hydroxypropyltrimonium chloride, hectorite, hyaluronic acid, hydrated silica, hydroxypropyl chitosan, hydroxypropyl guar, karaya gum, kelp, locust bean gum, natto gum, potassium alginate, potassium carrageenan, propylene glycol alginate, sclerotium gum, sodium carboxymethyl dextran, sodium carrageenan, tragacanth gum, xanthan gum, biosaccharide gum, or a combination thereof.

78. The composition of any one of claims 74-77, wherein the thickening agent comprises xanthan gum, guar gum, biosaccharide gum, cellulose, gum acacia, sclerotium gum, agarose, pectin, gellan gum, hyaluronic acid, or a combination thereof.

79. The composition of any one of claims 74-78, wherein the thickening agent comprises polymeric thickening agents selected from the group consisting of ammonium polyacryloyldimethyl taurate, ammonium acryloyldimethyltaurate / vinylpyrrolidone copolymer, sodium polyacrylate, acrylate copolymer, polyacrylamide, carbomer, acrylate / C10-30 alkyl acrylate crosspolymer, acrylamide / sodium acryloyldimethyltaurate copolymer, or a combination thereof.

80. The composition of any one of claims 74-79, wherein the preservative comprises gluconolactone, benzyl alcohol, calcium gluconate, sodium benzoate, phenoxyethanol, potassium sorbate, ethylhexylglycerin, caprylyl glycol, caprylhydroxamic acid, or a combination thereof.

81. The composition of any one of claims 74-80, wherein the preservative comprises benzoic acid, butyl paraben, diazolidinyl urea, DMDM hydantoin, ethyl paraben, imidazolidinyl urea, iodopropynyl butylcarbamate, isobutyl paraben, methyl paraben, methylchloroisothiazolinone, methylisothiazolinone, phenoxyethanol, propyl paraben, sodium benzoate, potassium sorbate, ethylhexylglycerin, gluconolactone, or a combination thereof.

82. The composition of any one of claims 1-81, wherein the composition has a viscosity of about 1 centipoise (cP) to about 60 cP.Attorney Docket No.63230-732.601 83. The composition of any one of claims 1-82, wherein the composition has a lather volume of about 1 cm3to about 10 cm3.

84. The composition of any one of claims 1-83, wherein the composition is dispensed using a foam dispenser.

85. A method for removing metals from hair, the method comprising using the composition of any one of claims 1-84.

86. A method of decreasing metal deposition onto hair, the method comprising: administering to hair a composition comprising: a chelator composition; a surfactant; and an anti-redeposition polymer, wherein the anti-redeposition polymer forms a coating adjacent to the hair, thereby decreasing metal deposition onto hair.

87. The method of claim 86, wherein the anti-redeposition agent comprises one or more functional groups having a net negative charge at a pH of about 4 to about 9, wherein the one or more functional groups chelates to a metal.

88. The method of claim 86 or claim 87, the method comprising administering a cleanser to the hair.

89. The method of claim 88, wherein (i) administering the cleanser to the hair is prior to (ii) administering to hair the composition comprising a chelator composition, a surfactant, and a redeposition polymer.

90. The method of claim 88, wherein (i) administering the cleanser to the hair is simultaneous with (ii) administering to hair the composition comprising a chelator composition, a surfactant, and a redeposition polymer.

91. A method of treating hair, wherein the method comprises: administering to hair a composition comprising:Attorney Docket No.63230-732.601 a chelator composition; and a toning dye, wherein the hair is bleached, as determined by measuring a E.

92. The method of claim 91, wherein the E of hair treated with the composition is lower when compared to a E of hair not treated with the composition.

93. The method of claim 91 or claim 92, wherein E is about 0 to about 30.

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