Device for checking a person's blood glucose concentration

Abstract

The invention relates to medicine, and more particularly to devices for non-invasively determining a person's blood glucose concentration, and can be used in the creation of systems for diagnosing diabetes. The present device comprises a housing, and a control and display module disposed in the housing. The device further comprises a sensor, a radiation emitter, and a receiver for receiving radiation reflected from a person's tissues, the emitter and the receiver being disposed in the sensor. Disposed on the working surface of the sensor is a rim which surrounds the light receiver and separates it from the light emitter. The device is incorporated into a smartphone, with a control and data processing unit being disposed in the housing of the smartphone and the device being powered by the power supply of the smartphone. The function of a data display panel is performed by the touchscreen of the smartphone, and the sensor is disposed on the rear surface of the smartphone housing, near the upper edge thereof. The invention provides a simplified design, the possibility of visually checking the correct positioning of the sensor on a pulse point, and the possibility of keeping the device in a working state using one hand while simultaneously operating the touchscreen using a digit of the same hand.

Description

[0001] A DEVICE FOR MONITORING THE CONTENT OF GLUCOSE IN HUMAN BLOOD

[0002] DESCRIPTION.

[0003] The invention relates to medicine and technology, specifically to the non-invasive determination of changes in glucose levels in human blood, and can find application in the creation of devices for this purpose, as well as in the creation of socially oriented systems for the early diagnosis of diabetes and related diseases located in a smartphone.

[0004] Prior art.

[0005] For diabetics, constant blood glucose monitoring is vital. New developments based on non-invasive methods that measure health parameters without drawing blood are currently being used for this purpose.

[0006] Numerous methods and devices have been developed for non-invasively determining changes in human blood glucose levels. Glucose is monitored using electrical transfer functions (RU Patent 2342071, published 2007), laser irradiation of areas of maximum blood vessel density on the mucous membrane (RU Patent 2295915, published 2005), sequential measurement of systolic and diastolic blood pressure on the left and right arms (RU Patent 2368303, published 2007), and even the human voice (RU Patent 2506893, published 20.02.2014).

[0007] A good non-invasive glucometer is a device in the form of a wristwatch - a “smart watch” that determines glucose, as well as pulse, pressure and other parameters (see source / 3 / ).

[0008] The best modern non-invasive glucometer is a wristwatch-style device—a "smartwatch"—that measures glucose, heart rate, blood pressure, and other parameters (see source / 1 / ). The device contains a sensor for monitoring the pulse wave signal, determining blood sugar levels, and other blood parameters. It also allows for manual location of the radial artery and targeting of the sensor. Changes in pulse wave parameters are used to determine changes in a person's blood sugar and other parameters.

[0009] Such a device contains a housing, a control and display module located in the housing, a sensor, a radiation emitter and a receiver of radiation reflected from human tissue, located in the sensor.

[0010] The control and display module contains a power source, a control and data processing unit, a data display panel made in the form of a touch screen, designed with the possibility of inputting and outputting information by touching it with a human finger.

[0011] The case with the control and display module resembles a wristwatch in appearance.

[0012] For simplicity, the control and display module may be referred to as the control module.

[0013] The sensor contains a light emitter and a light receiver and is positioned above the radial artery on a person's arm and is connected to a control and display module via a communication channel.

[0014] For simplicity, a device for non-invasive monitoring of glucose levels in human blood can be simply called a device.

[0015] The sensor in a device for noninvasively monitoring human blood glucose levels may be simply referred to as a sensor. For simplicity, the light emitter may be simply referred to as an emitter. For simplicity, the light receiver may be simply referred to as a receiver.

[0016] An analog of the invention is a wrist-worn device for non-invasive monitoring of human blood glucose levels using infrared light with a teletransmission function for determining blood glucose levels. (CN 110236487 A, published 2019.09.17).

[0017] The publication discloses the design of the device. The sensor included in the device includes an emitter and a receiver for radiation reflected from human tissue. The analog features, which match the features of the invention, include a housing, a control and display module located within the housing, a sensor, a radiation emitter, and a receiver for radiation reflected from human tissue, all located within the sensor.

[0018] The control and display module contains a power source, a control and data processing unit, a data display panel made in the form of a touch screen, designed with the possibility of inputting and outputting information by touching it with a human finger.

[0019] A disadvantage of the analog is the need to wear the device constantly, which many people find uncomfortable. Furthermore, there's no visual verification of proper placement of the sensor at the pulse measurement site. The sensor is located at the end of one of the strap sections. When placing the sensor at the pulse measurement site, the wearer can't see the sensor or the area on the arm where it needs to be pressed. The watch case and the wearer's arm obscure the sensor, resulting in poor accuracy in applying the sensor to the pulse measurement site.

[0020] The prototype of the invention is a device for non-invasive monitoring of glucose content in human blood, comprising a housing, a control and display module located in the housing, a sensor, a radiation emitter and a receiver of radiation reflected from human tissues, located in the sensor, and light is used as radiation, and on the working surface of the sensor there is a rim surrounding the light receiver and separating it from the light emitter, and the control and display module contains a power source, a control and data processing unit, a data display panel made in the form of a touch screen, and the touch screen is designed with the possibility of inputting and outputting information by touching it with a human finger, wherein the radiation emitter and the receiver of radiation reflected from human tissues are connected to the control and display module located in the housing via a wired communication line.

[0021] These features of the prototype coincide with the features of the invention.

[0022] Furthermore, the prototype's edge is rectangular in cross-section. The prototype's design is described in the article: New Developments in Wrist-Worn Devices for Non-Invasive Monitoring of Human Blood Glucose Levels and Other Health Parameters.

[0023] Terms and definitions. Tikhonenko D. O., Tikhonenko O. O., Lobko V. P., published in the collection: Higher school: scientific research. Proceedings of the Interuniversity International Congress (Moscow, October 13, 2023). Volume 1. - Moscow: Infinity Publishing House, 2023. - 170 p.

[0024] Also information about the prototype is posted in the source / 3 / .

[0025] The prototype works in conjunction with a smartphone. It connects to the smartphone via WiFi or Bluetooth when taking measurements. All data collected during measurements is transmitted to the smartphone.

[0026] A disadvantage of the prototype is the low operational efficiency for non-invasive monitoring of glucose levels in human blood due to the long time required for preparation for operation and setup.

[0027] Another drawback of the prototype is the need to constantly wear the device on the wrist (it is secured with a strap), which many people find uncomfortable. Furthermore, there is no visual verification of the sensor's correct placement at the pulse measurement site. The sensor is located at the end of one of the strap sections on the inner side. When placing the sensor at the pulse measurement site, the user cannot see the sensor or the area on the wrist where it is placed. The sensor is obscured by the device body and the user's arm. This results in low accuracy of sensor placement at the pulse measurement site, as well as high power consumption for noninvasive blood glucose monitoring due to the prototype's long preparation time.

[0028] The authors placed a device for non-invasive monitoring of human blood glucose levels in a smartphone.

[0029] A smartphone is a mobile phone with a touchscreen, equipped with a video camera, and a front-facing camera for video calls, video conferencing, and photography. Smartphones are currently very popular. Furthermore, a smartphone is a compact (pocket-sized) personal computer with the functionality of a mobile phone. By integrating a device for noninvasive blood glucose monitoring into a smartphone, the main drawbacks of the prototype are eliminated.

[0030] The essence of the invention.

[0031] The purpose of the invention is to improve the performance of a non-invasive blood glucose monitoring device integrated into a smartphone by reducing setup and configuration time. Performance is defined as speed and the ability to quickly bring the device into operation, specifically without frequent preliminary setup.

[0032] The objective is achieved in that the device for non-invasive monitoring of glucose levels in human blood comprises a housing, a control and display module located in the housing, a sensor, a radiation emitter and a receiver of radiation reflected from human tissues, located in the sensor, and light is used as radiation, and on the working surface of the sensor there is a rim surrounding the light receiver and separating it from the light emitter, and the control and display module contains a power source, a control and data processing unit, a data display panel made in the form of a touch screen, and the touch screen is designed with the possibility of inputting and outputting information by touching it with a human finger, wherein the radiation emitter and the receiver of radiation reflected from human tissues are connected to the control and display module located in the housing via a wired communication line, and differs from the prototype in that the device is made on the basis of a smartphone,wherein the control and data processing unit is located in the smartphone housing, the smartphone power source is used as the power source, the smartphone touch screen is used as the data display panel, and the sensor is located on the rear surface of the smartphone housing at the upper end side of the smartphone housing, wherein the light emitter and the light receiver are located on the working side of the sensor and are directed outward in the direction of an axis perpendicular to the longitudinal axis of the smartphone and perpendicular to the transverse axis of the smartphone; and when preparing for operation and during operation, the device is configured to press the sensor with the emitter and receiver to the place of palpation of the pulse on the radial artery of the arm; and, in addition, the device is configured to visually control the pressing of the sensor with the emitter and receiver to the place of palpation of the pulse on the radial artery of the arm; wherein the light emitter and the light receiver are made in such a way that when pressing the sensor to the hand in the working position,The light emitter is configured to emit light into the hand onto the radial artery, and the light receiver is configured to receive reflected light from the radial artery of the human hand; and, in addition, the device for non-invasive monitoring of glucose content in human blood is configured to be held in working condition by one hand of the person and to be able to input and output information by touching the touch screen with a finger of the same hand.

[0033] In a particular embodiment of the invention, the device can be designed in such a way that the sensor is located on the rear surface of the smartphone body at the upper end side of the smartphone body, in the left corner of the rear surface of the smartphone body.

[0034] In a particular embodiment of the invention, the device can be designed in such a way that the sensor is located on the rear surface of the smartphone body at the upper end side of the smartphone body, in the right corner of the rear surface of the smartphone body.

[0035] In a particular embodiment of the invention, the device can be made in such a way that when the sensor is in the working position, pressed to the hand, the light emitter is configured to emit light into the hand onto the radial artery at the base of the thumb of the human hand, or onto the radial artery of the wrist, or onto the radial artery of the forearm, and the receiver is configured to receive reflected light from the hand, namely, from the radial artery at the base of the thumb of the human hand, or from the radial artery of the wrist, or from the radial artery of the forearm.

[0036] In a particular embodiment of the invention, the device can be designed in such a way that the ridge of the side is made with projections and depressions alternating along its length, or riffles are made on the ridge of the side.

[0037] In a particular embodiment of the invention, the device can be designed in such a way that the ridge of the side is made with projections and depressions alternating along its length and grooves are made on the ridge of the side.

[0038] Furthermore, in a particular embodiment of the invention, the device can be designed so that, when preparing it for use, the pulse palpation site on the radial artery of the hand is moistened with water. This is accomplished by moistening the pulse palpation site on the radial artery of the hand during testing.

[0039] Also, in a specific embodiment of the invention, the device can be designed so that when preparing it for use, the pulse palpation site on the radial artery of the hand is wiped dry. This is done when testing the device, the pulse palpation site on the radial artery of the hand is wiped dry.

[0040] The device for non-invasive monitoring of human blood glucose levels will be called a “smartphone-based device for non-invasive monitoring of human blood glucose levels.”

[0041] For simplicity, we'll refer to the device for non-invasive blood glucose monitoring as the "device." When describing the device, we assume it's part of a smartphone.

[0042] When it is said that a device is based on a smartphone, it means that the smartphone is the basis for the device.

[0043] The foundation is the main thing upon which anything is built. In our case, the foundation is the smartphone upon which the device is based. For simplicity, we'll refer to the emitter and receiver of radiation reflected from human tissue as the emitter and receiver. The term "smartphone with a device for non-invasive blood glucose monitoring" can be simplified as "smartphone with device."

[0044] The device is used with the function of manually determining the location of the radial artery based on the pulse palpation site and aiming the emitter and receiver at it.

[0045] Technical results of the invention:

[0046] 1. There's no need to wear a non-invasive blood glucose monitoring device on your arm. For many people, wearing a device on your arm is inconvenient. This drawback is eliminated in the proposed device. The device, integrated into a smartphone, can be carried, for example, in a pocket, briefcase, or purse.

[0047] 2. Compared to the prototype, the device's design has been simplified by reducing the device's weight by eliminating the strap and integrating it into the smartphone. The device also utilizes the smartphone's touchscreen as the display panel and the smartphone's power source as the power source.

[0048] 3. Visual verification of the correct placement of the noninvasive blood glucose monitoring device sensor at the pulse site is provided. When placing the sensor at the pulse site, the user can see the sensor and the location on the arm where it should be pressed. This improves the accuracy of sensor placement at the pulse site, minimizing the risk of misplacing the sensor.

[0049] 4. It is possible to hold the device for non-invasive monitoring of human blood glucose levels in a smartphone in working condition when preparing it for operation and during operation using one hand and simultaneously operate the touch screen using a finger of the same hand.

[0050] 5. Reduction of energy consumption for non-invasive monitoring of human blood glucose levels due to precise orientation of the emitter and receiver to the artery and reduction of the preparation time of the device for non-invasive monitoring of human blood glucose levels for operation.

[0051] A specific technical result of creating a ridge on the edge with alternating protrusions and depressions or with ribs is an increase in the contact area of ​​the edge surface with the dry or wet hand surface at the sensor location. This increases the device's adhesion to the hand surface and helps maintain the noninvasive blood glucose monitoring device with the sensor at the pulse location.

[0052] Let us explain the achievement of technical results.

[0053] Setting up the claimed device is similar to setting up the prototype. A user configures the device to work with themselves.

[0054] The device, which is part of a smartphone, is then ready to carry out non-invasive monitoring of blood glucose levels.

[0055] To perform noninvasive blood glucose monitoring, a person sits still for 3 minutes. The arm is relaxed and placed, for example, on a table in front of the person. The pulse is felt at heart level.

[0056] After which, the person determines the place on the arm where the pulse is felt above the radial artery.

[0057] After this, the device, which is part of the smartphone, with a sensor (which is located on the back surface of the smartphone case at the upper end side of the smartphone case) is pressed tightly to the place where the pulse is felt, so that the sensor is opposite the radial artery in this place of the arm.

[0058] In this case, the emitter and receiver of reflected radiation, located in the sensor, are directed towards the radial artery.

[0059] Accuracy of the sensor's placement on the pulse site is visually verified. Both the sensor and the pulse site can be visually checked while applying the sensor.

[0060] The smartphone's design allows for easy visual monitoring of the pulse sensor application. While applying the sensor, the user can see both the sensor and the pulse sensor.

[0061] Afterwards, the person sits still for 3 minutes, holding the smartphone with the sensor device to their hand. The device is then turned on, and the device checks the sensor's position relative to the radial artery. The check takes up to 3 minutes.

[0062] When the sensor is correctly positioned, the user takes a measurement. The measurement lasts from 0.5 to 1.5 minutes.

[0063] The measurement result, namely sugar content, is then displayed on the screen. Other parameters may also be displayed, such as blood pressure, pulse, temperature, hemoglobin, cholesterol, uric acid, heart / lung / liver / brain function, and others.

[0064] If the sensor placement is incorrect (i.e., its location on the arm does not match the location on the arm when testing the sensor), a message will appear on the touch screen indicating the need to reinstall the sensor.

[0065] Testing of the prototype device revealed that initial setup requires at least three attempts. Each attempt takes up to 6 minutes. Afterward, the device is ready to measure blood sugar levels. Therefore, the prototype takes 18 minutes to perform the first measurement.

[0066] The prototype's shortcomings stem from the following: During the day, as a person walks and uses their hands, the sensor moves from its initial position. In this case, to perform a measurement, the sensor must be reset to its original position. The prototype lacks the ability to visually observe the sensor's positioning accuracy at the pulse measurement site. Both the sensor and the pulse measurement site are hidden from view by the strap and the device's casing.

[0067] Typically, people work intensively with their hands throughout the day. This causes the device to shift from its original position. A diabetic patient must measure their blood sugar levels multiple times a day—up to 10 or more (and sometimes up to 20 times). This requires resetting the sensor and adjusting the device for operation the same number of times. This can take up to three hours of measurement time per day, with 10 measurements. This is due to the rotation of the device and strap relative to the arm and radial artery.

[0068] The claimed smartphone-based device eliminates the need for wearers to wear the device on their wrist, which many people find inconvenient. Compared to the prototype, the device has been simplified by integrating it within the smartphone's housing.

[0069] The weight of the device itself is reduced due to the absence of a strap, as well as due to the fact that the smartphone's power source is used as a power source, and the smartphone's touch screen is used as a data display panel,

[0070] A person can carry a device that is part of a smartphone in a pocket or, for example, in a briefcase.

[0071] The device, which is located in the smartphone during setup and operation, provides visual verification of the sensor's placement at the pulse measurement site. When placing the sensor at the pulse measurement site, the user can see the sensor and the area on the arm where it should be pressed. This improves the accuracy of sensor placement. Misplacement of the sensor is minimized and virtually eliminated.

[0072] During the development of the invention, a prototype device was produced, shaped like a compact smartphone. The prototype allowed for interchangeable sensors and the attachment of sensors of various designs.

[0073] The experiments conducted suggest that the claimed smartphone-integrated device design virtually eliminates the need for repeated device and sensor configuration throughout the day. This reduces the time it takes to set up and implement noninvasive blood glucose monitoring by preventing erroneous readings.

[0074] Experiments demonstrated a 2.4-2.7-fold reduction in blood glucose measurement time (with ten measurements) compared to the prototype. Using a sensor with a rim containing protrusions and grooves or ridges on the ridge, the blood glucose measurement time was reduced by a factor of three (with ten measurements) compared to the prototype.

[0075] According to the invention, and this has been confirmed experimentally (as well as by experience using smartphones), it is possible to hold a smartphone with a device in a working state when preparing it for work and during work using one hand and simultaneously work with the touch screen using a finger of the same hand.

[0076] In addition, a reduction in energy consumption for non-invasive monitoring of human blood glucose levels is ensured by precise orientation of the emitter and receiver to the artery and a reduction in the time it takes to prepare the device for operation.

[0077] The dimensions of the smartphone and the device ensure that it can be held and operated comfortably with the fingers of one hand, whether by an adult or a child who is capable of using a smartphone.

[0078] Another important feature is that the wired connection from the sensor to the control and display module is shorter than in the prototype. In the prototype, the connection line runs through the strap and is kinked, reducing its reliability. In the proposed device, the connection line from the sensor to the control and display module runs exclusively within the smartphone body.

[0079] In the invention, the sensor has a rim on its inner housing that surrounds the light receiver and separates it from the light emitter. In a particular embodiment, the rim's ridge is formed with alternating projections and depressions along its length, or the rim's ridge is ribbed.

[0080] In other words, the curb is designed with a variable height along its length. Moreover, as it extends, the curb's height increases and decreases.

[0081] This increases the grip strength of the edge on the user's hand, thereby preventing the sensor and the smartphone and device from shifting from their original position. The prototype's edge has a constant height along its length.

[0082] List of figures.

[0083] Fig. 1 shows a device for non-invasive monitoring of human blood glucose levels, located in a smartphone. View from the touchscreen side.

[0084] Fig. 2 shows a device for non-invasive monitoring of glucose levels in human blood. View A.

[0085] Fig. 3 shows a device sensor comprising an emitter and a radiation receiver. The device is for non-invasive monitoring of glucose levels in human blood. Remote element B.

[0086] Fig. 4 shows a schematic cross-section of a human arm with the radial artery indicated, and also shows a sensor with emitters and a receiver of radiation reflected from human tissue, located above the radial artery at the site of palpation of the pulse.

[0087] Fig. 5 shows a schematic cross-section of a human arm, indicating the radial artery. It also shows a sensor with emitters and a receiver for reflecting radiation from human tissue, positioned above the radial artery at the pulse location. The beams emanating from the emitters into the arm, specifically the radial artery, are shown schematically, as are the reflected beams from the arm and the radial artery, directed toward the receiver.

[0088] Fig. 6 shows a view from the touchscreen of a smartphone containing a device for non-invasive blood glucose monitoring. The smartphone's dimensions are shown.

[0089] Fig. 7 shows a side view of a smartphone containing a device for non-invasively monitoring human blood glucose levels. View B. The thickness of the smartphone is shown.

[0090] Fig. 8 shows a view of the rear surface of the smartphone housing the device for noninvasive blood glucose monitoring. The sensor is shown. The sensor for the device for noninvasive blood glucose monitoring is located on the rear surface of the smartphone housing, near the top edge of the smartphone housing, in the left corner of the rear surface of the smartphone housing.

[0091] Fig. 9 shows the remote element G. The sensor of the device for non-invasive monitoring of glucose levels in human blood is shown, as well as elements of the smartphone.

[0092] Fig. 10 shows a view of the rear surface of the smartphone housing the device for noninvasive blood glucose monitoring. The sensor for the noninvasive blood glucose monitoring device is located on the rear surface of the smartphone housing, near the top edge of the smartphone housing, in the right corner of the rear surface of the smartphone housing.

[0093] Fig. 11 shows the remote element D. The sensor of the device for non-invasive monitoring of glucose content in human blood is shown in the right corner of the rear surface of the smartphone case.

[0094] Fig. 12 shows the side and part of the sensor with a receiver of the prototype device for non-invasive monitoring of glucose levels in human blood.

[0095] Fig. 13 shows the rim and a portion of the sensor with a receiver of a specific embodiment of the claimed device for noninvasively monitoring glucose levels in human blood. The rim's ridge is formed with alternating projections and depressions along its length.

[0096] Fig. 14 shows a development of the ridge of the rim. The rim is made with projections and depressions alternating along its length.

[0097] Fig. 15 shows a development of the ridge of the side. The projection shows the extension element A. The projection of the ridge is ribbed.

[0098] Fig. 16 shows the extension element A from Fig. 15. The projection of the side has grooves.

[0099] Fig. 17 shows a diagram of how to find the pulse on the left hand using the index finger of the right hand.

[0100] Fig. 18 shows the sensor with the transmitter and receiver being pressed against the pulse measurement site on the radial artery of the left arm. The sensor is located on the rear surface of the smartphone case, near the upper edge, in the right corner of the rear surface of the smartphone case.

[0101] Fig. 19 shows the sensor with the transmitter and receiver pressed against the pulse probe on the radial artery of the left hand and the touchscreen being operated using the index finger of the right hand. The sensor is located on the rear surface of the smartphone case, near the upper edge, in the right corner of the rear surface of the smartphone case.

[0102] Fig. 20 shows the sensor with the transmitter and receiver being pressed against the pulse measurement site on the radial artery of the left arm. The sensor is located on the rear surface of the smartphone case, near the top edge, in the left corner of the rear surface of the smartphone case.

[0103] Fig. 21 shows the sensor with the transmitter and receiver pressed against the pulse probe on the radial artery of the left hand and the touchscreen being operated using the index finger of the right hand. The sensor is located on the rear surface of the smartphone case, near the top edge, in the left corner of the rear surface of the smartphone case.

[0104] Fig. 22 shows a scan of the sensor flange with the geometric dimensions of the protrusions and recesses on the ridge (and on the edge) of the flange.

[0105] Fig. 23 shows a schematic representation of the sensor with dimensions.

[0106] Fig. 24 - 29 show the stages of pressing and visual control of pressing the sensor with the emitter and receiver to the place of palpation of the pulse on the radial artery of the hand.

[0107] Disclosure of invention.

[0108] The definition of the terms is given in the source / 2 / .

[0109] In terms of the sensor and its characteristics, the terms are given in article / 1 / .

[0110] A device for non-invasively monitoring human blood glucose levels is based on a smartphone. Below is a description of the device, as claimed in the independent and dependent claims.

[0111] The device is housed in the housing of smartphone 1 (see Fig. 1). The device for noninvasively monitoring human blood glucose levels comprises a control and display module, a sensor 3, a radiation emitter 4, and a receiver 5 for radiation reflected from human tissue, all located within sensor 3. Light is used as the radiation source.

[0112] On the working surface of the sensor 6 there is a rim 7 surrounding the light receiver 5 and separating it from the light emitter 4.

[0113] The control and display module comprises a power source 8, a control and data processing unit 2, and a data display panel in the form of a touchscreen 9. The touchscreen is configured to input and output information via a fingertip. The device utilizes a smartphone's touchscreen. The device also draws power from the smartphone's power source 8.

[0114] In this case, the radiation emitter 4 and the receiver 5 of the radiation reflected from human tissue are connected to the control and display module located in the smartphone body via a wired communication line 10. The sensor 3 contains a housing 11.

[0115] When storing the device, the sensor is covered with cover 12.

[0116] The longitudinal axis of the smartphone is indicated by position 17.

[0117] Thus, the device is based on a smartphone, with the control and data processing unit located in the smartphone body.

[0118] And the smartphone's touch screen is used as a data display panel.

[0119] Sensor 3 is located on the rear surface 13 of the smartphone housing near the upper end face 14 of the smartphone housing. The light emitter and light receiver are located on the sensor's operating side 6 and are directed outward toward axis 15, which is perpendicular to the smartphone's longitudinal axis 17 and perpendicular to the smartphone's transverse axis 16.

[0120] The lower end side of the smartphone body is marked with position 73.

[0121] The center of mass of the smartphone with the device is indicated by position 71. Axes 17, 16 and 15 can be drawn through the center of mass 71.

[0122] Fig. 4 shows a schematic cross-section of a human arm with the radial artery indicated, and also shows a device for non-invasive monitoring of glucose levels in human blood, which is part of a smartphone and a sensor with emitters and a receiver.

[0123] Sensor 18 is located on the rear surface 13 of the smartphone housing near the upper end face 14 of the smartphone housing. It contains emitters 19 and 20, as well as a radiation receiver 21.

[0124] The rear surface 13 of the smartphone housing is the surface that, in the operating position, is directed toward the human hand 22. The sensor is located on the surface of the hand 23 above the artery 24.

[0125] In this case, the light emitter 19 and the light emitter 20, as well as the light receiver 21 are located on the working side of the sensor 25 and are directed outward perpendicular to the longitudinal axis 17 of the smartphone.

[0126] The light emitter 19, as well as the 20 and light receiver 21, are designed in such a way that when the sensor 18 is pressed against the hand 22 in the working position, the light emitter is designed with the ability to emit light into the hand 22 onto the radial artery 24, and the light receiver 21 is designed with the ability to receive reflected light from the radial artery 24 of the human hand.

[0127] Fig. 5 schematically shows rays 26, 27 emanating from emitters 19 and 20 into the hand of a person 22, in particular, onto the radial artery 24, and shows reflected rays 28 from the hand of a person 22 and from the radial artery 24 towards the radiation receiver 21.

[0128] When preparing for work and during work, the device, which is part of a smartphone, is designed with the ability to press the sensor with the emitter and receiver to the place where the pulse is felt on the radial artery of the hand.

[0129] And, in addition, the device is designed with the ability to visually control the pressing of the sensor with the emitter and receiver to the place where the pulse is felt on the radial artery of the hand;

[0130] A smartphone with a device for non-invasively monitoring human blood glucose levels (see Figs. 18-21) is designed to be held in one hand, particularly by an adult, and to allow input and output of information by touching the touchscreen with a finger or fingers of the same hand (see Figs. 19 and 21). The user uses the index finger of the right hand to locate the pulse sensor on the left hand (see Fig. 17). The user holds the smartphone with the device in the left hand.

[0131] Fig. 6 shows a view from touchscreen 31 of smartphone 32, which houses a device for noninvasively monitoring human blood glucose levels. Reference numeral 29 denotes the upper end of the smartphone's housing. Reference numeral 30 denotes the smartphone's longitudinal axis.

[0132] Fig. 7 shows a side view of a smartphone containing a device for non-invasive monitoring of glucose levels in human blood, View B.

[0133] The sensor 33 is located on the rear surface 34 of the smartphone body at the upper end side 29 of the smartphone body, in the left corner 35 of the rear surface 34 of the smartphone body (see Figs. 7 - 9).

[0134] Fig. 8 shows a view of the rear surface 34 of the smartphone housing, in which a device for non-invasively monitoring human blood glucose levels is located. The sensor 33 of the device for non-invasively monitoring human blood glucose levels is located on the rear surface 34 of the smartphone housing at the upper end face 29 of the smartphone housing, in the left corner 35 of the rear surface of the smartphone housing 34. The right corner of the rear surface of the housing is designated by the number 41.

[0135] Fig. 9 shows the remote element G. The sensor 33 of the device for non-invasive monitoring of glucose levels in human blood is shown, as well as the elements of the smartphone: video camera 36 and flashlight 37. Also shown are emitters 48, 49 and receiver 50 of the sensor 33. The edge is designated by position 77.

[0136] Fig. 10 shows a view of the rear surface 38 of the smartphone housing, in which a device for non-invasive monitoring of glucose levels in human blood is located.

[0137] The sensor 39 of the device for non-invasive monitoring of glucose levels in human blood is located on the rear surface 38 of the smartphone housing at the upper end side 40 of the smartphone housing, in the right corner 79 of the rear surface 38 of the smartphone housing. Fig. 10 shows: a video camera 42, a flashlight 43, and a fingerprint recognizer 44 of the smartphone owner.

[0138] Fig. 11 shows the remote element D. The sensor 39 of the device for non-invasive monitoring of glucose content in human blood is shown in the right corner of the rear surface of the smartphone housing. Fig. 11 shows emitters 45, 46 and receiver 47.

[0139] Position 78 indicates the side. Position 79 indicates the right corner.

[0140] The devices for non-invasive monitoring of glucose content in human blood, shown in Figs. 1 - 11, are made in such a way that when the sensor is in the working position, pressed to the hand, the light emitter is configured to emit light into the hand onto the radial artery at the base of the thumb of the human hand, or onto the radial artery of the wrist, or onto the radial artery of the forearm, and the receiver is configured to receive reflected light from the hand, namely, from the radial artery at the base of the thumb of the human hand, or from the radial artery of the wrist, or from the radial artery of the forearm.

[0141] Fig. 12 shows a portion of the sensor 51 of the prototype device. The radiation receiver 52 surrounds the edge 53. The emitter is not shown in the figure.

[0142] In a particular embodiment of the claimed invention, a device for non-invasive monitoring of glucose levels in human blood comprises a sensor 81. And the sensor 81 can be made in such a way that the ridge 54 of the edge 55 is made with projections 56, 57, 58 and depressions 59, 60, 50 alternating along its length. The radiation receiver 80 surrounds the edge 55 (see Fig. 13). In addition, grooves can be made on the ridge of the edge (see Fig. 14).

[0143] Fig. 14 shows a development of 61 ridges of the rim. The ridge of the rim, and consequently the rim itself, is made with projections and depressions alternating along its length.

[0144] Fig. 15 shows a development 62 of the ridge of the side with projections 63, 64, 65 and recesses 66, 67. On projection 64, the extension element A is shown.

[0145] Fig. 16 shows the remote element A from Fig. 15. On the projection of the edge, grooves 68, 69, 70 are made. The longitudinal axis of the device for non-invasive monitoring of glucose content in human blood passes as shown in Fig. 6 (position 30). In a particular case, the longitudinal axis can pass through the center of mass of the device 97 (see Fig. 6), through the sensor, parallel to the plane of the touch screen.

[0146] The transverse axis of the smartphone with the device for non-invasive monitoring of glucose levels in human blood passes as shown in Figs. 1, 4 and 5 (position 17). Fig. 6 shows the longitudinal axis 30.

[0147] The transverse axis 16 is perpendicular to the longitudinal axis 17 and parallel to the surface of the touchscreen 9 (or parallel to the tangent plane to the surface of the touchscreen). See Fig. 1. In a particular case, the transverse axis may pass through the center of mass 71 of the smartphone with the device, perpendicular to the longitudinal axis 17, parallel to the surface of the touchscreen 9.

[0148] The longitudinal direction of the smartphone with the device in general and the body of the smartphone with the device in particular is the direction along the longitudinal axis of the smartphone with the device.

[0149] The transverse direction of the smartphone with the device in general and the body of the smartphone with the device in particular is the direction along the transverse axis of the smartphone with the device.

[0150] The diameter of the sensor 72 (see Fig. 11) is the maximum distance between two points from the set of points on the outer boundary of the sensor's cross-section. The working surface 6 of the sensor (see Fig. 3) is the surface of the sensor on which the emitter 4 and receiver 5 are located, as well as the flange 7 separating the emitter from the receiver. The working surface is also called the inner surface of the sensor.

[0151] The inner surface 6 of the sensor or the inner surface of the sensor housing is the surface that faces the human hand during non-invasive blood glucose monitoring.

[0152] The light emitter and light receiver are located on the working surface of the sensor and are directed outward in the direction of the axis 15 of the smartphone with the device (see Fig. 2), perpendicular to the longitudinal axis 17 of the smartphone with the device and perpendicular to the transverse axis 16 of the smartphone with the device. The upper end side 14 of the housing of the smartphone with the device for non-invasive monitoring of glucose levels in human blood is the side that, when the longitudinal axis of the smartphone is oriented vertically (with the primary operating vertical orientation of the monitor), is directed upward.

[0153] The lower end side 73 of the smartphone body (see Fig. 2) with a device for non-invasive monitoring of glucose levels in human blood is the side opposite the upper end side 14 of the smartphone with the device.

[0154] A border is a boundary around something, specifically the boundary around the surface of a sensor housing containing a light receiver. In other words, it is the boundary around the light receiver on the sensor's working surface (see Figs. 12, 13).

[0155] The ridge of the edge is the upper part of the edge, when the sensor is oriented in such a way that its emitter or emitters are directed away from the center of the earth - upwards (see article / 1 / ).

[0156] The front surface of a smartphone housing a device for noninvasive blood glucose monitoring (see Fig. 1) is the surface of the housing where the touchscreen is located. The front surface may be referred to as the front face, front side, or front surface of the smartphone housing the device.

[0157] The back surface of the smartphone housing with device 13 (see Fig. 2) for non-invasive monitoring of glucose levels in human blood is the surface opposite the front surface.

[0158] The side surface of the smartphone housing with a device for non-invasive monitoring of glucose levels in human blood is the surface located between the front and back surfaces of the smartphone.

[0159] A sensor 3 is located on the rear surface 13 of the smartphone housing with the device, near the upper end face 14 of the smartphone housing with the device (see Fig. 2). Preferably, the distance from the sensor to the upper end face is between 0.01 mm and 10 mm. In other words, the distance from the sensor to the upper end face is between 0.01 mm and 10 mm.

[0160] The term "near the top edge of the smartphone body" means that the sensor is located close to the top edge of the smartphone with the device or is positioned such that the distance from the sensor to the top edge is between 0.001 mm and 12 mm. As noted above, the preferred distance is between 0.01 mm and 10 mm.

[0161] If the sensor is located on the rear surface of the smartphone case at the top end of the smartphone case, in the left corner of the rear surface of the smartphone case, then the distance 98 (see Fig. 8) to the side surface is between 0.001 mm and 12 mm. The preferred distance is between 0.01 mm and 10 mm.

[0162] If the sensor is located on the rear surface of the smartphone case at the top end of the smartphone case, in the right corner of the rear surface of the smartphone case, then the distance 99 (see Fig. 11) to the side surface is between 0.001 mm and 12 mm. The preferred distance is between 0.01 mm and 10 mm.

[0163] The body of the smartphone with the device can be made elongated in the longitudinal direction, with a length from 130 mm to 200 mm (position 74 in Fig. 6), a width from 50 mm to 100 mm (position 75 in Fig. 6), a thickness from 5 mm to 15 mm (position 76 in Fig. 7), in addition, the length of the touch screen is from 126 mm to 196 mm, the width of the touch screen is from 46 mm to 96 mm, and the sensor is made with a diameter from 10 mm to 20 mm.

[0164] In Fig. 6 and 7 the following are indicated:

[0165] 74 – the length of a smartphone with a device for non-invasive monitoring of glucose levels in human blood;

[0166] 75 - width of the smartphone with the device;

[0167] 76 - thickness of the smartphone with the device;

[0168] In Fig. 11, position 72 indicates the diameter of sensor 39;

[0169] Fig. 6 shows the front surface of the smartphone housing with a device for noninvasively monitoring human blood glucose levels—the side on which the touchscreen is located. The front surface may be referred to as the front side. The front side of the smartphone housing is the front side of the smartphone housing the device for noninvasively monitoring human blood glucose levels. Fig. 8 shows a view of the rear surface of the smartphone housing, which houses the device for noninvasively monitoring human blood glucose levels. The rear surface may be referred to as the back side, or the rear side, or the rear surface of the smartphone housing the device.

[0170] Axis 15 (see Fig. 2) is an axis perpendicular to longitudinal axis 17 of the smartphone with a device for noninvasive monitoring of human blood glucose levels and perpendicular to transverse axis 16 of the smartphone with a device for noninvasive monitoring of human blood glucose levels. This axis is simply called the axis perpendicular to the longitudinal and transverse axes of the smartphone with the device.

[0171] Or an axis perpendicular to the longitudinal and transverse axes of a smartphone with a device for non-invasive monitoring of glucose levels in human blood.

[0172] Or an axis perpendicular to the longitudinal axis of the smartphone and perpendicular to the transverse axis of the smartphone.

[0173] Light, a radiation visible to the human eye, is used as radiation. In addition, radiation invisible to the human eye can also be used.

[0174] The device works as follows.

[0175] First, the device is configured. The configuration of the proposed device is similar to that of the prototype. A user performs a series of invasive blood sugar measurements and simultaneously a series of non-invasive measurements using a device located on a smartphone. The control and data processing unit then processes the received data and configures the device for a specific user.

[0176] The device, which is part of a smartphone, is then ready to carry out non-invasive monitoring of blood glucose levels.

[0177] To perform noninvasive blood glucose monitoring, a person sits still for 3 minutes. The arm is relaxed and placed, for example, on a table in front of the person. The pulse is felt at heart level.

[0178] After this, the person locates the location 82 on the arm where the pulse is felt above the radial artery (see Fig. 17). Fig. 24 also shows the pulse location 101 and the sensor 100 on the back surface of the smartphone housing at the upper end face of the smartphone housing.

[0179] After this, the device is pressed firmly against the place where the pulse is being felt, for example, on the wrist of the left hand, using, for example, the sensor of the right hand, so that the sensor is opposite the radial artery in this place of the hand (see Fig. 18).

[0180] In this case, the emitter and receiver of reflected radiation, located in the sensor, are directed towards the radial artery.

[0181] Accuracy of the sensor's placement on the pulse site is visually verified. Both the sensor and the pulse site can be visually checked while applying the sensor.

[0182] The smartphone's design allows for easy visual monitoring of the process of pressing the sensor against the pulse measurement site. The user can see both the sensor and the pulse measurement site.

[0183] After this, the person sits still for 3 minutes, holding the smartphone with the sensor device to their hand. Then, they turn on the device (see Fig. 19). To do this, they turn on the power and the control and data processing unit by pressing the "On" button on the smartphone body. The screen lights up.

[0184] The control unit checks the sensor's correct position relative to the radial artery. The check takes up to 3 minutes.

[0185] When the sensor is correctly located, the person scrolls through the “pages” on the screen with their finger until they reach the page that says: “Take a measurement.”

[0186] After which, the person presses the “Take measurement” button with his finger.

[0187] The "Start" button icon appears on the screen.

[0188] After which, the person presses the “Start” button with his finger (see Fig. 19).

[0189] The measurement has begun. The measurement lasts from 0.5 to 1.5 minutes.

[0190] The measurement results are then displayed on the screen: sugar level and other parameters, such as blood pressure. Depending on the device settings, the screen may display: sugar level, blood pressure, pulse, temperature, hemoglobin, cholesterol, uric acid, heart / lung / liver / brain function, etc. Figures 18 and 19 show sensor 83 with its emitter and receiver pressed against the pulse measurement site on the arm. The sensor is located on the rear surface of the smartphone, near the upper edge of the smartphone, in the right corner of the rear surface of the smartphone.

[0191] Figs. 20 and 21 show the application of sensor 84 with its transmitter and receiver to the pulse measurement site on the arm. Sensor 84 is located on the rear surface of the smartphone case, near the top edge of the smartphone case, in the left corner of the rear surface of the smartphone case.

[0192] Figs. 24-29 also show the stages of pressing and visually checking the pressing of the sensor with the emitter and receiver to the pulse palpation site on the radial artery of the hand. Fig. 24 shows determining the pulse palpation site. Figs. 25-28 show the process of pressing the sensor to the pulse palpation site. Fig. 29 shows operation of the right hand finger on the touch screen.

[0193] If the sensor's placement is incorrect (i.e., its location on the arm does not match the location on the arm during the sensor testing), a message appears on the touchscreen prompting the sensor to be reinstalled. The smartphone and device are turned off.

[0194] After this, the sensor is repositioned over the radial artery (the site where the pulse is felt). The patient sits still for 3 minutes, then turns on the device. The sensor placement continues until a message appears on the touchscreen indicating the device is ready for use. The user can now scroll through the pages on the screen.

[0195] Testing of the prototype device revealed that initial setup requires at least three attempts. Each attempt takes up to 6 minutes. Afterward, the device is ready to measure blood sugar levels. Therefore, the prototype takes 18 minutes to perform the first measurement.

[0196] The prototype's shortcomings stem from the following: During the day, as a person walks and uses their hands, the sensor moves from its initial position. In this case, to perform a measurement, the mobile sensor unit must be repositioned to its original position. The prototype lacks the ability to visually observe the sensor's positioning accuracy at the pulse measurement site. Both the sensor and the pulse measurement site are obscured from view by the strap and the device's casing.

[0197] Typically, people work intensively with their hands throughout the day. This causes the device to shift from its original position. A diabetic patient must measure their blood sugar levels multiple times a day—up to 10 or more (and sometimes up to 20 times). This requires resetting the sensor and adjusting the device for operation the same number of times. This can take up to three hours of measurement time per day, with 10 measurements. This is due to the rotation of the device and strap relative to the arm and radial artery.

[0198] The invention eliminates the need to wear the device on the wrist, which many people find inconvenient. Compared to the prototype, the device has been simplified by being housed within the smartphone's body.

[0199] The weight of the device itself is reduced by eliminating the strap, using the smartphone's power source as a power source, and using the smartphone's touchscreen as a data display panel.

[0200] A person can carry the device as part of a smartphone in a pocket or briefcase.

[0201] The device, which is located in the smartphone during setup and operation, provides visual verification of the sensor's placement at the pulse measurement site. When placing the sensor at the pulse measurement site, the user can see the sensor and the area on the arm where it should be pressed. This improves the accuracy of sensor placement. Misplacement of the sensor is minimized and virtually eliminated.

[0202] During the development of the invention, a prototype device was manufactured, shaped like a compact smartphone or a flat prismatic keychain. The prototype allowed for interchangeable sensors and the attachment of sensors of various designs.

[0203] The experimental sample of the device has a body made elongated in the longitudinal direction, 80 mm long, 43 mm wide, 12 mm thick, the length of the touch screen is 50 mm, the width of the touch screen is 43 mm, the sensor is made with a diameter of 15 mm.

[0204] The experiments conducted suggest that the claimed smartphone-integrated device design virtually eliminates the need for repeated device and sensor configuration throughout the day. This reduces the time it takes to set up and implement noninvasive blood glucose monitoring by preventing erroneous readings.

[0205] Experiments demonstrated a 2.4-2.7-fold reduction in blood glucose measurement time (with ten measurements) compared to the prototype. Using a sensor with a rim containing protrusions and grooves or ridges on the ridge, the blood glucose measurement time was reduced by a factor of three (with ten measurements) compared to the prototype.

[0206] According to the invention, and this has been confirmed experimentally (as well as by experience using smartphones), it is possible to hold a smartphone with a device in a working state when preparing it for work and during work using one hand and simultaneously work with the touch screen using a finger of the same hand.

[0207] In addition, a reduction in energy consumption for non-invasive monitoring of human blood glucose levels is ensured by precise orientation of the emitter and receiver to the artery and a reduction in the time it takes to prepare the device for operation.

[0208] The dimensions of the smartphone and the device ensure that it can be held and operated comfortably with the fingers of one hand, whether by an adult or a child who is capable of using a smartphone.

[0209] Another important feature is that the wired connection from the sensor to the control and display module is shorter than in the prototype. In the prototype, the connection line runs through the strap and is kinked, reducing its reliability. In the proposed device, the connection line from the sensor to the control and display module runs exclusively within the smartphone body.

[0210] Description of experiments with a smartphone-based device for noninvasive blood glucose monitoring. As noted above, during the development of the invention, an experimental prototype of the device was manufactured, shaped like a compact smartphone.

[0211] The experiments involved 10 volunteer test subjects aged 16 to 65 years.

[0212] Before testing, each tester tested the sensor and the experimental device as a whole, and configured it to work on their hand.

[0213] After testing the experimental device, the tester measured blood sugar levels 10 times a day for one month.

[0214] The experiments tested whether it was possible to hold the experimental device for non-invasive monitoring of human blood glucose levels in a working state during preparation for operation and during operation with one hand and simultaneously operate the touch screen with a finger of the same hand.

[0215] Based on the test results, it was established that holding the experimental device sample and operating the touch screen with the fingers of one hand is possible.

[0216] It was found that the average time for ten measurements over a single day was 65-75 minutes, which is 2.4-2.7 times faster than the prototype. When using a sensor with a rim containing protrusions and indentations (or grooves) on the ridge, the average time for ten measurements over a single day was 60 minutes. This reduced the time required to measure blood glucose levels by a factor of three compared to the prototype.

[0217] The reduction in measurement time, compared to the prototype, results in reduced energy consumption for noninvasive blood glucose monitoring. This reduction is achieved by precisely targeting the emitter and receiver to the artery and reducing the setup time of the smartphone-based device for noninvasive blood glucose monitoring.

[0218] The experimental device featured interchangeable sensors. The interchangeable sensors differed in the design of their rims. The rim ridges of the interchangeable sensors were designed with alternating protrusions and depressions along their length, and the rim ridges also had grooves (see Figs. 14–16).

[0219] Table 1 presents the geometric characteristics of the sensors and flanges on the tested sensor housings. The sensor housing and flange material are plastic.

[0220] Table 2 presents the characteristics of the protrusions and recesses on the side of the experimental sensor variants.

[0221] The sensor is made with a diameter in the range from 10 mm to 20 mm.

[0222] In the invention, the sensor has a rim on its inner housing that surrounds the light receiver and separates it from the light emitter. In a particular embodiment, the rim's ridge is formed with alternating projections and depressions along its length, or the rim's ridge is ribbed.

[0223] In other words, the curb is designed with a variable height along its length. Moreover, as it extends, the curb's height increases and decreases.

[0224] In other words, along the length of the side, sections with a greater height alternate with sections with a lower side height.

[0225] This increases the adhesion force of the edge to the user's hand, thereby preventing the sensor from shifting from its original installation location. When implementing a edge with a constant height along the edge, as in the prototype, the term "edge height" is defined as follows. Edge height is the distance between the inner surface of the sensor and a plane tangent to the edge of the edge / 1 / .

[0226] The height of the side may be variable along the length of the side, as in the claimed invention.

[0227] If the sidewall is made with a variable height along the entire length of the sidewall, then the term “average sidewall height” or the term “sidewall height in the longitudinal section of the sidewall” or “sidewall height in the i-th longitudinal section of the sidewall” can be used.

[0228] The term "maximum curb height" can also be used. The maximum curb height is the largest of the set of curb heights obtained by constructing multiple longitudinal curb sections.

[0229] The minimum height of the side is the minimum of the set of side heights obtained by constructing a set of longitudinal sections of the side.

[0230] Fig. 22 shows a scan of the sensor flange with the geometric dimensions of the protrusions and recesses on the flange's ridge (and edge). The following are indicated in the figure:

[0231] 85 - width of the projection;

[0232] 86 - recess width;

[0233] 87 - height of the projection;

[0234] 88 - length of the side (side development);

[0235] 89 - side height.

[0236] Fig. 23 shows a schematic representation of the sensor with dimensions. The following are indicated in the figure:

[0237] 90 - sensor body;

[0238] 91 - side;

[0239] 92 - sensor diameter;

[0240] 93 - outer diameter of the flange;

[0241] 94 - inner diameter of the rim;

[0242] 95 - side height;

[0243] 96 – thickness of the sensor body.

[0244] The geometric characteristics of protrusions and recesses can be characterized by the empirical (obtained on the basis of experiments) coefficient “K”.

[0245] K = H / h, where H is the maximum height of the side; h is the minimum height of the side.

[0246] Conducted studies have shown that the coefficient K can take values ​​from 0.0001 to 0.5.

[0247] In a particular embodiment, the coefficient K can take values ​​from 0.0001 to 0.01, or in another particular embodiment, the coefficient K can take values ​​from 0.01 to 0.1, or in another particular embodiment, the coefficient K can take values ​​from 0.1 to 0.2, or in another particular embodiment, the coefficient K can take values ​​from 0.2 to 0.3, or in another particular embodiment, the coefficient K can take values ​​from 0.3 to 0.4, or in another particular embodiment, the coefficient K can take values ​​from 0.4 to 0.5.

[0248] The average height of the side is the arithmetic mean between the smallest and largest heights in the longitudinal sections of the side along its length.

[0249] In addition, when preparing it for operation and when the sensor is operating, the emitter and receiver are pressed to the place where the pulse is felt on the radial artery of the wrist.

[0250] This ensures improved sensor performance. Testing several sensor variants with different rim designs showed that a rim ridge with alternating protrusions and indentations along its length, or a rim ridge with ribs, reduces blood glucose measurement time compared to the prototype.

[0251] Additionally, a mock-up of the device within a smartphone was conducted. It was determined that the stated distances from the sensor to the top edge and to the side surfaces ensure visual verification of the correct placement of the sensor at the pulse measurement site. This non-invasive, smartphone-based blood glucose monitoring device is designed for monitoring human blood glucose levels.

[0252] From the above, it follows that the invention achieves its objective. It improves the performance of a device for non-invasive blood glucose monitoring within a smartphone by reducing setup and configuration time.

[0253] The technical results of the invention are also achieved.

[0254] There's no need to wear the non-invasive blood glucose monitoring device on your arm. Compared to the prototype, the device has been simplified by reducing its weight by eliminating the strap and making it smartphone-based.

[0255] Visual verification of the correct placement of the smartphone-based noninvasive blood glucose monitoring device's sensor at the pulse site is provided. When placing the sensor at the pulse site, the user can see the sensor and the location on the arm where it should be pressed. This improves the accuracy of sensor placement at the pulse site, minimizing the risk of misplacing the sensor.

[0256] It is possible to hold a device for non-invasive monitoring of human blood glucose levels based on a smartphone in a working state when preparing it for operation and during operation using one hand and simultaneously operate the touch screen using a finger of the same hand.

[0257] Reduced energy consumption for non-invasive monitoring of human blood glucose levels is achieved by precisely orienting the emitter and receiver to the artery and reducing the time it takes to prepare the smartphone-based device for operation.

[0258] A specific technical result of creating a ridge on the edge with alternating protrusions and depressions or with ribs is an increase in the contact area of ​​the edge surface with the dry or wet surface of the hand at the sensor location. This helps keep the smartphone, device, and sensor in place at the pulse measurement site.

[0259] Table 1

[0260] Geometric characteristics of the sensors and flanges on the sensor housings submitted for testing. The sensor housing and flange material is plastic.

[0261] Table 2

[0262] Characteristics of the protrusions and recesses on the side of the experimental sensor variants Literature.

[0263] 1. Tikhonenko D.O., Tikhonenko O.O., Lobko V.P. NEW DEVELOPMENTS IN THE FIELD OF WRIST-WEARING DEVICES FOR NON-INVASIVE MONITORING OF HUMAN BLOOD GLUCOSE CONTENT, AS WELL AS FOR MONITORING OTHER HUMAN HEALTH PARAMETERS. TERMS AND DEFINITIONS. Higher school: scientific research. Proceedings of the Interuniversity International Congress (Moscow, October 13, 2023). Volume 1. - Moscow: Infinity Publishing House, 2023, 61-98 pp., BBK 65, ISBN 978-5-905695-53-7, DOI 10.34660 / INF.2023.68.11.381 htt s: / / studylib.net / doc / 27163933 / kongress-13-oktyabrya-2023-tom-1

[0264] 2. Tikhonenko D.O., Tikhonenko O.O., Lobko V.P. NEW DEVELOPMENTS IN THE FIELD OF NON-INVASIVE MONITORING OF GLUCOSE CONTENT IN HUMAN BLOOD, AS WELL AS MONITORING OF OTHER HUMAN HEALTH PARAMETERS. A DEVICE FOR NON-INVASIVE MONITORING BASED ON A SMARTPHONE. TERMS AND DEFINITIONS. Collection of scientific articles based on the results of the International Scientific Forum SCIENCE AND INNOVATIONS - MODERN CONCEPTS (Moscow, March 28, 2024). Volume 2. - Moscow: Infinity Publishing House, 2024, 60-86 pp., UDC 330, BBK 65, C56, ISBN 978-5-905695-78-0, DOI 10.34660 / INF.2024.56.78.052 https: / / studylib.net / doc / 27425879 / novye-razrabotki-v-oblasti-neinvazivnogo-kontrolya- soderzha

[0265] 3. Accofrisk Smartwatch. https: / / accofrisk.com / ru / non-invasive-smartwatch

Claims

Invention formula 1. A device for non-invasive monitoring of glucose levels in human blood, comprising a control and display module, a sensor, a radiation emitter and a receiver of radiation reflected from human tissue, located in the sensor, and light is used as radiation, and on the working surface of the sensor there is a rim surrounding the light receiver and separating it from the light emitter, and the control and display module contains a power source, a control and data processing unit, a data display panel made in the form of a touch screen, and the touch screen is designed with the possibility of inputting and outputting information by touching it with a human finger, wherein the radiation emitter and the receiver of radiation reflected from human tissue are connected to the control and display module located in the housing via a wired communication line, characterized in that the device is made on the basis of a smartphone, and the control and data processing unit is located in the housing of the smartphone,the power source is a smartphone power source, the data display panel is a smartphone touch screen, and the sensor is located on the rear surface of the smartphone housing at the upper end side of the smartphone housing, wherein the light emitter and the light receiver are located on the working side of the sensor and are directed outward in the direction of an axis perpendicular to the longitudinal axis of the smartphone and perpendicular to the transverse axis of the smartphone; and when preparing for operation and during operation, the device is configured to press the sensor with the emitter and receiver to the site of palpation of the pulse on the radial artery of the arm; and, in addition, the device is configured to visually control the pressing of the sensor with the emitter and receiver to the site of palpation of the pulse on the radial artery of the arm; wherein the light emitter and the light receiver are designed in such a way that, When the sensor is pressed against the hand in the working position, the light emitter is configured to emit light into the hand onto the radial artery, and the light receiver is configured to receive reflected light from the radial artery of the human hand; and, in addition, the device for non-invasive monitoring of glucose content in human blood is configured to be held in the working position by one hand of the person and to be able to input and output information by touching the touch screen with a finger of the same hand.

2. The device according to paragraph 1, characterized in that the sensor is located on the rear surface of the smartphone body at the upper end side of the smartphone body, in the left corner of the rear surface of the smartphone body.

3. The device according to paragraph 1, characterized in that the sensor is located on the rear surface of the smartphone body at the upper end side of the smartphone body, in the right corner of the rear surface of the smartphone body.

4. The device according to claim 1, characterized in that while the sensor is in the working position, pressed to the hand, the light emitter is configured to emit light into the hand onto the radial artery at the base of the thumb of the human hand, or onto the radial artery of the wrist, or onto the radial artery of the forearm, and the receiver is configured to receive reflected light from the hand, namely, from the radial artery at the base of the thumb of the human hand, or from the radial artery of the wrist, or from the radial artery of the forearm.

5. The device according to paragraph 1, characterized in that the ridge of the side is made with projections and depressions alternating along its length, or ribbing is made on the ridge of the side.

6. The device according to paragraph 1, characterized in that the ridge of the side is made with projections and depressions alternating along its length and that grooves are made on the ridge of the side.

Images