Fully-automatic closed cell preparation all-in-one machine

Abstract

Provided is a fully-automatic closed cell preparation all-in-one machine, comprising a rack. An inclined surface is arranged on the upper portion of the rack, and a tube hanging frame is mounted on the inclined surface; a hanging assembly is arranged at the position of the rack close to the upper portion of the tube hanging frame, and a transversely extending platform is arranged at the position of the rack close to the lower side of the inclined surface. In addition, a centrifugal assembly is arranged on one side of the platform, the platform is further provided with a storage table, and a magnetic separation assembly is arranged on the inclined surface and at a position approximately at the upper portion of the rack; the magnetic separation assembly comprises a housing, and a tube clamping assembly and a magnetic separation unit are arranged in the housing; and the tube clamping assembly comprises an upper chuck assembly and a lower chuck assembly. When the magnetic separation amount is relatively large, a magnetic separation tubing is rapidly replaced, the magnetic separation tubing can be driven to rotate in cooperation with a rotating assembly during magnetic separation, so that the magnetic separation effect can be improved.

Description

Full-automatic closed cell preparation integrated machine TECHNICAL FIELD

[0001] The present application relates to the technical field of cell preparation, in particular to a full-automatic closed cell preparation integrated machine. BACKGROUND

[0002] Cell preparation refers to the process that scientific and technical personnel use relatively mature cell culture scheme to prepare high-purity target cell final product, which can be directly applied to scientific research and clinical fields after function and quality detection. In the process of cell preparation and cell culture, the prepared or cultured cells must be detected, including various exogenous factors, cell morphology, cell number, cell activity, cell phenotype analysis and other tests representing the quality of cell preparation or culture, to ensure that the cells are uncontaminated, high-purity, high-activity and effective cells during the preparation and culture process and when finally collected and used. The traditional cell preparation method is to use culture bottles or culture dishes for manual culture in a clean laboratory by scientific researchers. In order to culture a large number of cells, technical personnel with high level of operation are needed, a large amount of time is spent, and a large number of culture bottles and culture space are also needed. The culture efficiency is low, and large-scale production cannot be realized. Although there are some automatic cell preparation equipment on the market, the magnetic separation part of these equipment cannot quickly switch the magnetic separation pipe, cannot meet the continuous large amount of magnetic separation operation, and the fixed magnetic separation pipe has general magnetic separation effect. Therefore, the present application provides a full-automatic closed cell preparation integrated machine. SUMMARY

[0003] Based on the technical problems existing in the background art, the present application provides a full-automatic closed cell preparation integrated machine.

[0004] The full-automatic closed cell preparation integrated machine provided by the present application comprises a rack, an inclined surface is arranged on the upper part of the rack, a pipe hanging rack is installed on the inclined surface, a hanging assembly is arranged on the rack near the upper part of the pipe hanging rack, a horizontally extending platform is arranged on the lower side of the rack near the inclined surface, a centrifugal assembly is arranged on one side of the platform, a storage table is further arranged on the platform, a magnetic separation assembly is arranged on the upper part of the rack near the inclined surface, the magnetic separation assembly comprises a shell, a pipe clamping assembly and a magnetic separation unit are arranged in the shell;

[0005] The pipe clamping assembly comprises an upper clamping disc assembly and a lower clamping disc assembly;

[0006] The lower clamping disc assembly comprises a disc, equidistant annularly distributed mounting holes are arranged on the disc, a rotating sleeve is rotatably arranged in the mounting hole, and equidistant annularly distributed metal springs are arranged on the inner side of the rotating sleeve, the metal springs have an arc structure, and the upper end of the metal spring is fixedly connected with the inner top of the rotating sleeve;

[0007] The upper chuck assembly comprises a first motor fixed at a position of the top of the shell, and the first motor is coaxially fixed with a positioning circular plate through the outer wall of the top of the shell, the lower part of the positioning circular plate is provided with equidistant annularly distributed connecting rods, the lower ends of the connecting rods are fixedly connected with a disc, the disc is coaxially arranged with the positioning circular plate, the positioning circular plate is provided with equidistant annularly distributed notched grooves, the lower part of the positioning circular plate is rotatably provided with two coaxial rotating discs, the two rotating discs are both provided with clamping units near the positions of the notched grooves, the clamping unit comprises two clamping blocks, and the two clamping blocks are arranged on the two rotating discs respectively, the thickness of the clamping block is the sum of the thicknesses of the two rotating discs, metal shafts are arranged on the two clamping blocks, and compression wheels are rotatably arranged on the two metal shafts, second inclined surfaces are arranged on the sides of the two clamping blocks away from the ends of the rotating discs, a convex column is arranged at the position between the two notched grooves of the positioning circular plate, and a V-shaped elastic sheet is fixedly arranged on the convex column.

[0008] The magnetic separation unit comprises a U-shaped magnet capable of moving laterally, and a linkage assembly is arranged between the magnetic separation unit and the pipe clamping unit to realize lateral movement of the U-shaped magnet when the lower chuck assembly rotates.

[0009] The magnetic separation unit arranged herein can move laterally, when the magnetic separation unit approaches the pipe clamping assembly, the magnetic separation pipe clamped on the pipe clamping assembly falls into the inner side of the U-shaped magnet, the movement of the U-shaped magnet is controlled, and the magnetic separation work can be performed, the hanging assembly in the device is used for hanging the target medium bag, the medium bag is connected with a pipeline, the pipeline passes through the pipe hanging rack, and a peristaltic pump is also installed on the pipe hanging rack, the pipeline connected with the medium bag is used for transferring liquid through the peristaltic pump, and the valve assembly capable of clamping each pipeline is arranged on the pipe hanging rack, so that the opening and closing switching between different pipelines is realized, thereby realizing the supply of different reagents, and the display assembly is used for displaying the operating parameters of the equipment and performing interactive operation through touch.

[0010] As a further optimization of the technical solution, the lower chuck assembly and the upper chuck assembly are provided with a rotating assembly, the rotating assembly comprises a second motor fixed at the lower part of the shell, the output shaft of the second motor is coaxially arranged with the output shaft of the first motor, the output shaft of the second motor is fixed with a circular shaft through the shell, the circular shaft is coaxially provided with a circular disc, the outer circumferential surface of the circular disc is wrapped with a rubber layer, and the circular disc is provided with a through hole through which the circular shaft passes.

[0011] As a further optimization of the technical solution, the circular disc is fixedly provided at the lower part with equidistant annularly distributed lamp holders, and lamp tubes are fixedly arranged on the lamp holders.

[0012] In the preferred embodiment, a conductive slip ring can be installed on the circular shaft to supply power to the lamp holder during the rotation of the circular shaft.

[0013] As a further optimization of the technical solution, the application discloses a full-automatic closed cell preparation all-in-one machine, and the magnetic separation unit comprises a movable block, guide holes are arranged on the upper portion and the lower portion of the magnetic separation unit in a transverse mode, guide rods are inserted into the two guide holes, the two guide rods are fixedly connected with the inner wall of one side of the shell, springs are arranged on the outer circumferential surface of the guide rods and close to the two sides of the movable block, a limiting cap is arranged at the end of the guide rod close to the upper chuck assembly, an inner side of the U-shaped magnet is provided with a rotating shaft, a rectangular gap is arranged at the middle position of the side of the movable block close to the upper chuck assembly, the rotating shaft is rotationally connected with the inner wall of the rectangular gap, and a rectangular plate is fixedly arranged at the position close to the rectangular gap of the movable block.

[0014] As a further optimization of the technical solution, the application discloses a full-automatic closed cell preparation all-in-one machine, and the U-shaped magnet is provided with an elastic reset piece which is fixedly arranged on the outer side close to the bending portion, the inner side of the rectangular gap is provided with a slot for accommodating the elastic reset piece, and the elastic reset piece is inserted into the slot.

[0015] As a further optimization of the technical solution, the application discloses a full-automatic closed cell preparation all-in-one machine, and the linkage assembly comprises a trigger rod which is fixed at the lower position of the side of the movable block close to the upper chuck assembly, a roller accommodating groove is arranged at the end of the trigger rod away from the movable block, and a roller is rotationally arranged in the roller accommodating groove, the height of the roller is consistent with that of the disc, the outer circumferential surface of the disc is provided with a plurality of trigger sector-shaped protrusions, the gap between two adjacent trigger sector-shaped protrusions corresponds to the position of the rotating sleeve, one end of the trigger sector-shaped protrusion is provided with a first inclined surface portion, the end of the trigger sector-shaped protrusion away from the first inclined surface portion is provided with a straight edge portion, and the straight edge portion extends along the radial direction of the disc.

[0016] As a further optimization of the technical solution, the application discloses a full-automatic closed cell preparation all-in-one machine, and the shell is provided with an opening at the side away from the pipe hanging rack, and the shell is provided with a U-shaped gap at the position close to the U-shaped magnet.

[0017] As a further optimization of the technical solution, the application discloses a full-automatic closed cell preparation all-in-one machine, and the inner side of the shell is provided with a groove portion extending away from the upper chuck assembly, the guide rod is fixedly arranged on the inner side of the groove portion, and the groove portion is provided with a space for the movement of the movable block.

[0018] As a further optimization of the technical solution, the application discloses a full-automatic closed cell preparation all-in-one machine, and the shell is hingedly provided with a side cover at the side away from the pipe hanging rack, and the side cover is arranged at the side away from the magnetic separation unit.

[0019] As a further optimization of the technical solution, the application discloses a full-automatic closed cell preparation integrated machine, a display assembly is fixedly arranged on the upper part of the rack, a protective cover is hingedly arranged on the rack close to the hanging assembly, and the protective cover is made of transparent material.

[0020] As can be seen, the beneficial effects in the application are:

[0021] The plurality of magnetic selection pipe fittings can be quickly switched, the magnetic selection pipe fittings can be quickly replaced when the magnetic selection amount is large, the magnetic selection pipe fittings can be driven to rotate in cooperation with the rotating assembly during the magnetic selection process, the magnetic selection effect can be improved, the condition of the magnetic selection pipe fitting is observed conveniently in cooperation with the lamp tube, and the U-shaped magnet is automatically separated from the magnetic selection pipe fitting in the process of switching the magnetic selection pipe fitting, and the U-shaped magnet can be cooperated with the next magnetic selection pipe fitting in place, so that the operation is convenient. BRIEF DESCRIPTION OF DRAWINGS

[0022] Fig. 1 is a structural schematic view of the full-automatic closed cell preparation integrated machine;

[0023] Fig. 2 is a structural schematic view of the full-automatic closed cell preparation integrated machine without the protective cover;

[0024] Fig. 3 is a structural schematic view of the magnetic selection assembly of the full-automatic closed cell preparation integrated machine;

[0025] Fig. 4 is a structural schematic view of the shell of the full-automatic closed cell preparation integrated machine;

[0026] Fig. 5 is a structural schematic view of the magnetic selection unit of the full-automatic closed cell preparation integrated machine;

[0027] Fig. 6 is a structural schematic view of the pipe clamping assembly of the full-automatic closed cell preparation integrated machine;

[0028] Fig. 7 is a structural schematic view of the upper chuck assembly of the full-automatic closed cell preparation integrated machine;

[0029] Fig. 8 is an exploded structural schematic view of the upper chuck assembly of the full-automatic closed cell preparation integrated machine;

[0030] Fig. 9 is a structural schematic view of the rotating disc of the full-automatic closed cell preparation integrated machine;

[0031] Fig. 10 is a structural schematic view of the rotating assembly of the full-automatic closed cell preparation integrated machine;

[0032] Fig. 11 is a structural schematic view of the lower chuck assembly of the full-automatic closed cell preparation integrated machine;

[0033] Fig. 12 is a schematic view of the structure of a rotating sleeve of a full-automatic closed cell preparation integrated machine according to the present application.

[0034] In the figure: 1, frame; 2, centrifugal assembly; 3, placement table; 4, magnetic separation assembly; 401, housing; 4011, recessed part; 4012, guide rod; 4013, spring; 402, side cover; 403, first motor; 404, second motor; 405, lower chuck assembly; 4051, disc; 4052, rotating sleeve; 40521, metal spring; 4053, trigger sector-shaped protrusion; 40531, first inclined surface part; 40532, straight edge part; 406, upper chuck assembly; 4061, positioning disc; 40611, connecting rod; 40612, V-shaped elastic sheet; 40613, protruding column; 4062, rotating disc; 40621, clamping block; 406211, second inclined surface part; 40622, metal shaft; 40623, pressing wheel; 407, magnetic separation unit; 4071, movable block; 40712, trigger rod; 40713, roller; 40714, rectangular gap; 4072, U-shaped magnet; 40721, rotating shaft; 40722, elastic reset sheet; 4073, rectangular plate; 408, rotating assembly; 4081, circular shaft; 4082, circular wheel disc; 4083, lamp holder; 4084, lamp tube; 5, display assembly; 6, tube hanging rack; 7, protective cover; 8, hanging assembly. DETAILED DESCRIPTION

[0035] The technical solutions in the embodiments of the present application will be described clearly and completely below with reference to Figs. 1-12 of the drawings in the embodiments of the present application. Obviously, the described embodiments are only some of the embodiments of the present application, rather than all the embodiments. Based on the embodiments in the present application, all other embodiments obtained by those skilled in the art without creative work fall within the scope of protection of the present application.

[0036] With reference to Figs. 1-12, a full-automatic closed cell preparation integrated machine includes a frame 1, an inclined surface is arranged on the upper part of the frame 1, and a tube hanging rack 6 is installed on the inclined surface, a hanging assembly 8 is arranged on the frame 1 near the upper part of the tube hanging rack 6, a horizontally extending platform is arranged on the frame 1 near the lower side of the inclined surface, a centrifugal assembly 2 is arranged on one side of the platform, a placement table 3 is further arranged on the platform, a magnetic separation assembly 4 is arranged on the inclined surface near the upper part of the frame 1, the magnetic separation assembly 4 includes a housing 401, and a tube clamping assembly and a magnetic separation unit 407 are arranged in the housing 401;

[0037] The tube clamping assembly includes an upper chuck assembly 406 and a lower chuck assembly 405;

[0038] The lower chuck assembly 405 comprises a disc 4051, mounting holes are arranged on the disc 4051 in equidistant annular distribution, a rotating sleeve 4052 is rotatably arranged in the mounting hole, and metal springs 40521 are arranged on the inner side of the rotating sleeve 4052 in equidistant annular distribution; the metal springs 40521 are in arc structure, and the upper end of the metal spring 40521 is fixedly connected with the inner side top of the rotating sleeve 4052;

[0039] The upper chuck assembly 406 comprises a first motor 403 fixed at the top position of the shell 401, and a positioning disc 4061 is coaxially fixed on the first motor 403 through the top outer wall of the shell 401; equidistant annular distribution connecting rods 40611 are arranged on the lower part of the positioning disc 4061, the lower end of the connecting rod 40611 is fixedly connected with the disc 4051, the disc 4051 is coaxially arranged with the positioning disc 4061, equidistant annular distribution notches are arranged on the positioning disc 4061, and two rotating discs 4062 are rotatably arranged on the lower part of the positioning disc 4061 in a coaxial manner; a clamping unit is arranged on each of the two rotating discs 4062 near the notch; the clamping unit comprises two clamping blocks 40621, the two clamping blocks 40621 are arranged on the two rotating discs 4062 respectively, the thickness of the clamping block 40621 is the sum of the thicknesses of the two rotating discs 4062, metal shafts 40622 are arranged on the two clamping blocks 40621, pressure wheels 40623 are rotatably arranged on the two metal shafts 40622, second inclined surfaces 406211 are arranged on the sides of the two clamping blocks 40621 away from the rotating discs 4062, a convex column 40613 is arranged on the positioning disc 4061 between the two notches, and a V-shaped elastic sheet 40612 is fixedly arranged on the convex column 40613.

[0040] The magnetic separation unit 407 comprises a U-shaped magnet 4072 which can move laterally; the magnetic separation unit 407 and the pipe clamping unit are provided with a linkage assembly which can realize lateral movement of the U-shaped magnet 4072 when the lower chuck assembly 405 rotates.

[0041] The magnetic separation unit 407 arranged herein can move laterally; when the magnetic separation unit 407 approaches the pipe clamping assembly, the magnetic separation pipe clamped on the pipe clamping assembly falls into the inner side of the U-shaped magnet 4072, the U-shaped magnet 4072 is controlled to work, and the magnetic separation work can be performed; the hanging assembly 8 in the device is used for hanging the target medium bag, the medium bag is connected with a pipeline, the pipeline passes through the pipe hanging rack 6, a peristaltic pump is also arranged on the pipe hanging rack 6, the pipeline connected with the medium bag passes through the peristaltic pump to transfer liquid, the valve assembly which can clamp each pipeline is arranged on the pipe hanging rack 6 to realize opening and closing switching between different pipelines, so that different reagents can be supplied; the display assembly 5 is used for displaying the operating parameters of the equipment and performing interactive operation through touch.

[0042] Referring to FIG. 3, FIG. 6 and FIG. 10, a rotating assembly 408 is arranged between the lower chuck assembly 405 and the upper chuck assembly 406, the rotating assembly 408 comprising a second motor 404 fixed at the lower part of the housing 401, the output shaft of the second motor 404 being coaxially arranged with the output shaft of the first motor 403, the output shaft of the second motor 404 being fixed with a round shaft 4081, a round disc 4082 being coaxially arranged on the round shaft 4081, the outer circumferential surface of the round disc 4082 being wrapped with a rubber layer, the disc 4051 being provided with a through hole for the round shaft 4081 to pass through.

[0043] Referring to FIG. 10, a plurality of lamp holders 4083 are fixedly arranged at the lower part of the round disc 4082 in a ring shape at equal distances, and a lamp tube 4084 is fixed on the lamp holders 4083. Here, a conductive slip ring can be installed on the round shaft 4081 to supply power to the lamp holders 4083 during the rotation of the round shaft 4081.

[0044] Referring to FIG. 4, FIG. 5 and FIG. 6, the magnetic separation unit 407 comprises a movable block 4071, the upper and lower parts of the magnetic separation unit 407 are provided with transversely arranged guide holes, guide rods 4012 are inserted into the two guide holes, the two guide rods 4012 are fixedly connected with the inner wall of one side of the housing 401, springs 4013 are sleeved on the outer circumferential surface of the guide rods 4012 close to the both sides of the movable block 4071, a limiting cap is arranged at the end of the guide rod 4012 close to the upper chuck assembly 406, a rotating shaft 40721 is arranged at the inner side of the U-shaped magnet 4072, a rectangular gap 40714 is arranged at the intermediate position of the side of the movable block 4071 close to the upper chuck assembly 406, the rotating shaft 40721 is rotationally connected with the inner wall of the rectangular gap 40714, and a rectangular plate 4073 is fixedly arranged at the position of the movable block 4071 close to the rectangular gap 40714.

[0045] Referring to FIG. 5, an elastic reset piece 40722 is fixedly arranged at the outer side of the U-shaped magnet 4072 close to the curved part, a slot for accommodating the elastic reset piece 40722 is arranged at the inner side of the rectangular gap 40714, and the elastic reset piece 40722 is inserted into the slot.

[0046] Referring to FIG. 5, FIG. 6 and FIG. 11, the linkage assembly comprises a trigger lever 40712 fixed at the lower part of the movable block 4071 near one side of the upper chuck assembly 406, and a roller accommodating groove is arranged at the end of the trigger lever 40712 away from the movable block 4071, and a roller 40713 is rotatably arranged in the roller accommodating groove, the roller 40713 is consistent with the height of the disc 4051, the outer circumferential surface of the disc 4051 is provided with a plurality of trigger sector-shaped protrusions 4053, the gap between two adjacent trigger sector-shaped protrusions 4053 corresponds to the position of the rotating sleeve 4052, one end of the trigger sector-shaped protrusion 4053 is provided with a first inclined surface part 40531, and a straight edge part 40532 is arranged at the end of the trigger sector-shaped protrusion 4053 away from the first inclined surface part 40531, and the straight edge part 40532 extends along the radial direction of the disc 4051.

[0047] Referring to FIG. 3, the shell 401 is provided with an opening away from the pipe hanging rack 6, and a U-shaped notch is arranged at the position of the U-shaped magnet 4072.

[0048] Referring to FIG. 4, the inner side of the shell 401 is provided with a groove part 4011 extending away from the upper chuck assembly 406, a guide rod 4012 is fixed inside the groove part 4011, and a space is arranged inside the groove part 4011 for the movement of the movable block 4071.

[0049] Referring to FIG. 3, the shell 401 is hinged with a side cover 402 away from the pipe hanging rack 6, and the side cover 402 is arranged away from the magnetic separation unit 407.

[0050] Referring to FIG. 1 and FIG. 2, the rack 1 is fixedly provided with a display assembly 5 at the upper part.

[0051] Referring to FIG. 1 and FIG. 2, the rack 1 is hingedly provided with a protective cover 7 near the hanging assembly 8, and the protective cover 7 is made of transparent material.

[0052] Working principle: when in use, the medium bag is hung on the hanging assembly 8, the protective cover 7 outside the hanging assembly 8 can protect the medium bag on the hanging assembly 8 and facilitate observation, the medium bag enters the centrifugal assembly 2 according to the timing, quantity, speed and other predetermined program control parameters, high-speed centrifugation is carried out in the centrifugal assembly 2, and automatic separation, extraction and transfer to the medium bag are carried out through the set program and image algorithm, waste liquid is discharged, magnetic bead incubation is carried out in the centrifugal assembly 2, after the incubation is completed, the medium bag is transferred back to the centrifugal assembly 2 to complete the filtration, and then is transferred to the magnetic separation assembly 4, the cell mixed liquid in the branch pipeline also enters the magnetic separation pipe, and the magnetic separation pipe is arranged in the U-shaped magnet 4072, so that the cells with magnetic beads are adsorbed on the wall of the magnetic separation pipe, the remaining cell liquid flows into the lower medium bag, the magnetic separation assembly leaves the U-shaped magnet 4072, the cells with magnetic beads are eluted to the upper medium bag, and finally the cell sorting is completed, and the counting module is arranged to realize automatic counting and continuous monitoring. The cultivation process of the cells is carried out in the centrifugal assembly 2, and the liquid transfer in the whole process is powered by the peristaltic pump on the hanging pipe rack 6, and the opening and closing switching of the pipeline is carried out by cooperating with the electromagnetic pipe clamp valve on the hanging pipe rack 6.

[0053] Especially need to explain is, the application optimizes the magnetic separation assembly 4, can place multiple magnetic separation tube components on the pinch tube assembly, and can drive the whole pinch tube assembly to rotate through the driving of the first motor 403, switch each magnetic separation tube component, and the two ends of the magnetic separation tube component are detachably connected to the medium pipeline, different magnetic separation tube components can be switched as needed, and how the magnetic separation tube component is installed on the pinch tube assembly will be specifically introduced below. The lower end of the magnetic separation tube component is inserted into the rotating sleeve 4052 on the disc 4051, the metal spring 40521 in the rotating sleeve 4052 presses the lower end of the magnetic separation tube component, reduces the shaking, and then the upper end of the magnetic separation tube component is pushed along the second inclined surface 406211, so that it falls into the two clamping blocks 40621, the elastic force provided by the cooperatively arranged V-shaped elastic sheet 40612 is used to realize the mutual approach of the clamping blocks 40621 on the adjacent two rotating discs 4062, the outer wall of the magnetic separation assembly is in contact with the outer wall of the circular disc 4082, and the magnetic separation tube component is pressed by the cooperatively arranged compression wheel 40623, the second motor 404 is controlled to work, so as to drive the circular disc 4082 and the magnetic separation tube component to rotate, improve the magnetic separation effect, here the rotation joint is used to realize the rotation of the pipeline and the two ends of the magnetic separation tube component, so that the magnetic separation tube component can rotate under the driving of the circular disc 4082, in the process of switching each magnetic separation tube component, under the cooperation of the first inclined surface 40531 of the trigger sector-shaped lug 4053, the rotating disc 4051 drives the trigger sector-shaped lug 4053 to rotate, drives the trigger lever 40712 and the movable block 4071 to move, so as to separate the U-shaped magnet 4072 from the magnetic separation assembly, then with the rotation of the disc 4051, when the trigger lever 40712 falls into the gap between the two trigger sector-shaped lugs 4053, the movable block 4071 pushes the U-shaped magnet 4072 to move transversely under the action of the spring, and is aligned with another magnetic separation tube component, it is particularly pointed out that the U-shaped magnet 4072 here comprises a U-shaped core and a coil sleeved on the U-shaped core, after the coil is energized, a magnetic field from one end of the U-shaped core to the other end is generated, since the magnetic field at the center of the magnetic field will weaken outward, in combination with the circular disc 4082, the magnetic separation tube component is driven to rotate, so that the magnetic separation effect is improved, and then the lamp 4084 installed on the rotating assembly 408 can illuminate the magnetic separation tube component, facilitating observation of the magnetic separation result.

[0054] For purposes of the description hereinafter, the orientations in the various figures will be described, as it is for ease in the descriptions. However, it should be appreciated that the application can assume any orientation, and the generic terms described herein could be used accordingly.

[0055] It is also important to note that the use of terminology such as "first" and / or "second" from the beginning of the description is for clarity, and does not necessarily mean that the terms so used are to be taken literally. For example, the terms "first" and "second" can be used to distinguish between two objects, and does not necessarily mean that the objects are to be used in a particular order. As such, the terms "first" and "second" can be used interchangeably, and the application described herein can be practiced in other than the order discussed herein. Further, the terms "include" and "have," and any variations thereof, are intended to cover a non-exclusive inclusion, such that a process, method, system, product or apparatus that comprises a list of elements is not necessarily limited to those elements, but can include other elements not expressly listed or inherent to such process, method, system, product or apparatus.

[0056] It should also be noted that, as used in the specification and the appended claims, the articles "a," "an," and "the" can mean one or more, depending upon the context of their use. Still further, the term "about" can be used to indicate that a value contains some degree of error, consistent with the value's function, or the environment of use. Also, the term "substantially" can be used to indicate that a value, condition, or circumstance is acceptable, even though not perfect, in terms of the function being performed, or the environment of use.

[0057] The foregoing description of the exemplary embodiment of this application has been presented for the purposes of illustration and description. It is not intended to be exhaustive or to limit the application to the precise form disclosed. Many modifications and variations are possible in light of the above teaching. It is intended that the scope of the application be limited not with this detailed description, but rather by the claims appended hereto.

Claims

1. A fully automatic closed cell preparation all-in-one machine, comprising a rack (1), the upper part of the rack (1) is provided with an inclined surface, and a hanging pipe rack (6) is installed on the inclined surface, a hanging assembly (8) is arranged on the rack (1) near the upper part of the hanging pipe rack (6), a horizontally extending platform is arranged on the rack (1) near the lower side of the inclined surface, and a centrifugal assembly (2) is arranged on one side of the platform, and a storage table (3) is further arranged on the platform, and a magnetic separation assembly (4) is arranged on the inclined surface near the upper part of the rack (1), characterized in that, The magnetic separation assembly (4) comprises a shell (401), a pipe clamping assembly and a magnetic separation unit (407) are arranged in the shell (401); The pipe clamping assembly comprises an upper clamping disc assembly (406) and a lower clamping disc assembly (405); The lower clamping disc assembly (405) comprises a disc (4051), mounting holes are arranged on the disc (4051) in equidistant annular distribution, a rotating sleeve (4052) is rotatably arranged in the mounting hole, and metal springs (40521) are arranged on the inner side of the rotating sleeve (4052) in equidistant annular distribution; the metal springs (40521) are in arc structure, and the upper end of the metal spring (40521) is fixedly connected with the inner side top of the rotating sleeve (4052); The upper clamping disc assembly (406) comprises a first motor (403) fixed at the top position of the shell (401), and a positioning disc (4061) is coaxially fixed on the first motor (403) through the top outer wall of the shell (401); equidistant annular distribution connecting rods (40611) are arranged on the lower part of the positioning disc (4061), the lower end of the connecting rod (40611) is fixedly connected with the disc (4051), the disc (4051) is coaxially arranged with the positioning disc (4061), equidistant annular distribution notches are arranged on the positioning disc (4061), and two rotating discs (4062) are rotatably arranged on the lower part of the positioning disc (4061) in a coaxial manner; a clamping unit is arranged on each rotating disc (4062) near the notch, the clamping unit comprises two clamping blocks (40621), the two clamping blocks (40621) are arranged on the two rotating discs (4062) respectively, the thickness of the clamping block (40621) is the sum of the thicknesses of the two rotating discs (4062), metal shafts (40622) are arranged on the two clamping blocks (40621), pressure wheels (40623) are rotatably arranged on the two metal shafts (40622), second inclined surfaces (406211) are arranged on the sides of the two clamping blocks (40621) away from the rotating discs (4062), a convex column (40613) is arranged on the positioning disc (4061) between the two notches, and a V-shaped elastic sheet (40612) is fixedly arranged on the convex column (40613). The magnetic separation unit (407) comprises a U-shaped magnet (4072) capable of moving laterally, and a linkage assembly is arranged between the magnetic separation unit (407) and the pipe clamping unit, so that the U-shaped magnet (4072) moves laterally when the lower clamping disc assembly (405) rotates.

2. The automatic closed cell preparation machine of claim 1, wherein, The lower chuck assembly (405) and the upper chuck assembly (406) are provided with a rotating assembly (408), the rotating assembly (408) comprises a second motor (404) fixed at the lower part of the shell (401), the output shaft of the second motor (404) is coaxially arranged with the output shaft of the first motor (403), the output shaft of the second motor (404) is fixed with a round shaft (4081) penetrating through the shell (401), the round shaft (4081) is coaxially provided with a circular disc (4082), the outer periphery of the circular disc (4082) is wrapped with a rubber layer, the disc (4051) is provided with a through hole for the round shaft (4081) to penetrate.

3. The fully automatic closed cell preparation all-in-one machine according to claim 2, characterized in that, The lower part of the circular disc (4082) is fixedly provided with lamp holders (4083) distributed in a ring shape at equal distances, and the lamp holders (4083) are fixed with lamp tubes (4084).

4. The fully automatic closed cell preparation all-in-one machine according to claim 3, characterized in that, The magnetic separation unit (407) comprises a movable block (4071), the upper and lower parts of the magnetic separation unit (407) are provided with transversely arranged guide holes, guide rods (4012) are inserted into the two guide holes, the two guide rods (4012) are fixedly connected with the inner wall of one side of the shell (401), spring (4013) is sleeved on the outer periphery of the guide rod (4012) close to the both sides of the movable block (4071), and the end of the guide rod (4012) close to the upper chuck assembly (406) is provided with a limiting cap, the inner side of the U-shaped magnet (4072) is provided with a rotating shaft (40721), the movable block (4071) is provided with a rectangular gap (40714) at the middle position of the side close to the upper chuck assembly (406), and the rotating shaft (40721) is rotatably connected with the inner wall of the rectangular gap (40714), and the movable block (4071) is fixedly provided with a rectangular plate (4073) at the position close to the rectangular gap (40714).

5. The fully automatic closed cell preparation all-in-one machine according to claim 4, characterized in that, The outer side of the U-shaped magnet (4072) is fixedly provided with an elastic reset piece (40722) close to the bending part, the inner side of the rectangular gap (40714) is provided with a slot accommodating the elastic reset piece (40722), and the elastic reset piece (40722) is inserted into the slot.

6. The fully automatic closed cell preparation all-in-one machine according to claim 5, characterized in that, The linkage assembly comprises a trigger lever (40712) fixed at the lower part of the movable block (4071) near one side of the upper chuck assembly (406), and a roller accommodating groove is arranged at the end of the trigger lever (40712) away from the movable block (4071), and a roller (40713) is rotatably arranged in the roller accommodating groove, the roller (40713) is consistent with the height of the disc (4051), the outer periphery of the disc (4051) is provided with a plurality of trigger sector-shaped protrusions (4053), the gap between two adjacent trigger sector-shaped protrusions (4053) corresponds to the position of the rotating sleeve (4052), one end of the trigger sector-shaped protrusion (4053) is provided with a first inclined surface portion (40531), and a straight edge portion (40532) is arranged at the end of the trigger sector-shaped protrusion (4053) away from the first inclined surface portion (40531), and the straight edge portion (40532) extends along the radial direction of the disc (4051).

7. The fully automatic closed cell preparation all-in-one machine according to claim 6, characterized in that, The shell (401) is provided with an opening away from the pipe hanging rack (6), and the shell (401) is provided with a U-shaped notch near the position of the U-shaped magnet (4072).

8. The fully automatic closed cell preparation all-in-one machine according to claim 7, characterized in that, The inner side of the shell (401) is provided with a groove portion (4011) extending away from the upper chuck assembly (406), the guide rod (4012) is fixed inside the groove portion (4011), and the groove portion (4011) is provided with a space for the movement of the movable block (4071).

9. The fully automatic closed cell preparation all-in-one machine according to claim 1, characterized in that, The shell (401) is hinged with a side cover (402) away from the pipe hanging rack (6), and the side cover (402) is arranged away from the magnetic separation unit (407).

10. The fully automatic closed cell preparation all-in-one machine according to claim 1, characterized in that, The rack (1) is fixedly provided with a display assembly (5) at the upper part, the rack (1) is hingedly provided with a protective cover (7) near the pipe hanging assembly (8), and the protective cover (7) is made of transparent material.

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