Mosquito-repellent and sunscreen cosmetic composition and preparation method therefor

Abstract

A mosquito-repellent and sunscreen cosmetic composition and a preparation method therefor. The mosquito-repellent and sunscreen cosmetic composition comprises the following components in parts by weight: 3-5 parts of N,N-diethyl-2-hydroxy-2-phenylacetamide porous plant protein nanospheres, 1-3 parts of nanohybrid hyperbranched polymer HB-TiO2 <sb / >, 0.8-1.2 parts of D-camphoric acid / hydroxy-terminated polyether polycondensate, 2-3 parts of a traditional Chinese medicine extract, 0.1-0.3 parts of a transdermal agent, 1-2 parts of a plant extract, 40-60 parts of water, 3-5 parts of a cosolvent, and 0.5-1 part of a natural emulsifier. The mosquito-repellent and sunscreen cosmetic composition exhibits good sun screening effect, good biocompatibility, and long-acting mosquito repellency without toxic or side effects, can whiten and moisten the skin, and provides anti-aging, freckle- removing, and skincare benefits.

Description

A mosquito repellent and sunscreen cosmetic composition and its preparation method Technical Field

[0001] This invention relates to the field of cosmetic technology, and in particular to a mosquito repellent and sunscreen cosmetic composition and its preparation method. Background Technology

[0002] The market is currently flooded with a wide variety of cosmetics, among which mosquito repellent and sunscreen cosmetic compositions are quite common. These cosmetics can protect the skin from the effects of ultraviolet rays, preventing UVA rays from oxidizing the reduced melanin in the epidermis and directly tanning the skin. UVA rays can also cause the nucleic acids or proteins in the epidermal cells to denature, resulting in acute dermatitis, erythema or burns, skin cracking, telangiectasia, photodermatitis, ecchymosis, and loss of elasticity.

[0003] With the improvement of people's living standards and the development of the cosmetics industry, more and more sunscreen cosmetic compositions have appeared on the market. However, existing sunscreen cosmetic compositions often have many problems. For example, most commercially available sunscreens add high levels of sunscreen active ingredients to achieve the required UV protection level. These high levels of sunscreen active ingredients not only increase the cost of the product but also make the product feel unpleasant to use and can irritate the skin. Many sunscreen ingredients are unstable and lose their effectiveness when exposed to ultraviolet rays. As a result, sunscreens cannot effectively block ultraviolet rays after use, thus causing greater damage to the skin.

[0004] Most sunscreen cosmetics on the market do not have antiviral or antibacterial effects. In recent years, the market demand for antiviral and antibacterial daily chemical products has been large, and the performance requirements for them have also become higher and higher. Most viruses rely on live parasites such as mosquitoes to spread. Developing daily chemical products that are non-toxic and have significant effects in repelling, antiviral and antibacterial properties, as well as good cleaning, toning and skin care properties, is a problem that industry researchers urgently need to solve.

[0005] Chinese invention patent application number 201080042258.8 discloses a sunscreen cosmetic composition, characterized by the inclusion of (1) one or more UVA absorbers selected from diethylaminohydroxybenzoylhexylbenzoate, 2,4-bis{[4-(2-ethylhexyloxy)-2-hydroxy]-phenyl}-6-(4-methoxyphenyl)-1,3,5-triazine, 4-tert-butyl-4-methoxydibenzoylmethane, and 2-hydroxy-4-methoxydibenzophenone, and (2) a resin spherical powder containing more than 35% hydrophobically treated ultrafine titanium dioxide particles. The purpose of this invention is to provide a sunscreen cosmetic composition containing UVA absorbers and ultrafine titanium dioxide particles that prevents stains caused by secondary adhesion to clothing. However, the UVA absorbers contained in these cosmetics have poor biocompatibility and easily cause skin itching and erythema after use.

[0006] Therefore, it is particularly important to develop a mosquito repellent and sun protection cosmetic composition with few toxic side effects, good mosquito repellent and sun protection effects, skin whitening effect, and good user comfort. Summary of the Invention

[0007] The main objective of this invention is to provide a mosquito-repellent and sun-protective cosmetic composition. This composition has good sun protection effect, excellent biocompatibility, no toxic side effects, and can whiten and moisturize the skin, as well as have anti-aging, freckle-removing, and skin-care effects. Furthermore, this invention also provides a method for preparing the aforementioned mosquito-repellent and sun-protective cosmetic composition. This method is simple, reproducible, easy to operate, and requires minimal investment.

[0008] To achieve the above objectives, the technical solution adopted by the present invention is as follows:

[0009] A mosquito repellent and sunscreen cosmetic composition, characterized in that it comprises the following components in parts by weight: 3-5 parts of N,N-diethyl-2-hydroxy-2-phenylacetamide porous plant protein nanospheres, 1-3 parts of nano-hybridized hyperbranched polymer HB-TiO2, 0.8-1.2 parts of D-camphoric acid / terminated hydroxyl polyether condensate, 2-3 parts of traditional Chinese medicine extract, 0.1-0.3 parts of transdermal agent, 1-2 parts of plant extract, 40-60 parts of water, 3-5 parts of cosolvent, and 0.5-1 part of natural emulsifier.

[0010] Furthermore, the co-solvent is at least one of glycerol, hyperbranched polyglycerol G4, and ethylene glycol.

[0011] Preferably, the plant extract is a mixture of cabbage extract and broccoli extract in a mass ratio of 3:5.

[0012] Preferably, the plant extract has a ratio of 10:1 and a particle size of 80-100 mesh.

[0013] Preferably, the transdermal agent is at least one selected from borneol, peppermint oil, wintergreen oil, and clove oil.

[0014] Preferably, the natural emulsifier is at least one of lecithin, lanolin, lanolin alcohol, lanolin acid, and beeswax.

[0015] Preferably, the herbal extract is made from the following raw materials in parts by weight: 1-4 parts of Artemisia argyi, 2-3 parts of white pomegranate, 2-4 parts of calamus, 2-3 parts of bitter melon, 1-3 parts of astaxanthin, 2-5 parts of dandelion, 1-4 parts of calendula, 1-3 parts of peppermint, 3-5 parts of red clover, 3-6 parts of Isatis indigotica, and 1-3 parts of verbena.

[0016] Preferably, the method for preparing the herbal extract includes the following steps: mixing the raw materials according to their weight proportions to obtain a mixed medicinal material, then decocting the mixed medicinal material in water for 1-3 hours, filtering, rotary evaporation to concentrate, vacuum filtering, and drying to obtain the herbal extract.

[0017] Preferably, the mass ratio of the mixed medicinal materials to water is 1:(4-8).

[0018] Preferably, the preparation method of the D-camphoric acid / hydroxyl-terminated polyether condensate includes the following steps: adding D-camphoric acid and hydroxyl-terminated polyether to a high-boiling-point solvent and stirring until homogeneous to form a solution; then adding (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride) and N-hydroxysuccinimide to the solution; stirring and reacting at 110-150°C for 8-16 hours; then removing the solvent by rotary evaporation; washing with diethyl ether; and drying in a vacuum drying oven at 85-95°C to constant weight to obtain the D-camphoric acid / hydroxyl-terminated polyether condensate.

[0019] Preferably, the molar ratio of D-camphoric acid, hydroxyl-terminated polyether, high-boiling-point solvent, (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride), and N-hydroxysuccinimide is 1:1:(6-10):(0.8-1.2):0.5.

[0020] Preferably, the high-boiling-point solvent is at least one of dimethyl sulfoxide, N,N-dimethylformamide, and N-methylpyrrolidone.

[0021] Preferably, the method for preparing the N,N-diethyl-2-hydroxy-2-phenylacetamide porous plant protein nanospheres is as follows: gelatin and nano-plant protein are mixed at a mass ratio of 2:1 and dissolved in distilled water at 60°C; N,N-diethyl-2-hydroxy-2-phenylacetamide is mixed with the above solution at a mass ratio of 1:10; the mixture is stirred at a low temperature of 35°C and 280-450 r / min for 3-4.5 h; after cooling to room temperature, a dispersant is added; and the mixture is washed with water, filtered, air-dried, and then ultra-finely pulverized and dried to obtain the final product.

[0022] The method for preparing the nano-plant protein is as follows: plant cellulose and distilled water are mixed at a mass ratio of 1:10 to 1:20, and ultrasonicated at a power of 2500W and an oscillation frequency of 28kHz for 4 hours. Then, anhydrous ethanol is added at -20℃ to -5℃, and the mixture is freeze-dried and pulverized to obtain nano-plant protein. The method for preparing the nano-hybrid hyperbranched polymer HB-TiO2 is basically the same as that of Chinese Invention Patent Example 1 with application number 201910425260.6, except that nano-titanium dioxide is used instead of nano-silica.

[0023] Another object of the present invention is to provide a method for preparing the mosquito repellent and sunscreen cosmetic composition, characterized by comprising the following steps: mixing each component evenly according to the weight parts, stirring at 800-1100 r / min for 25-35 min to obtain the mosquito repellent and sunscreen cosmetic composition.

[0024] Due to the application of the above technical solution, the present invention has the following advantages compared with the prior art:

[0025] (1) The preparation method of the mosquito repellent and sun protection cosmetic composition provided by the present invention can be made by simply stirring each component evenly. No special equipment or special reagents are required. The labor intensity is low, the operation is simple and convenient, the repeatability is good, the operability is strong, and the capital investment is low.

[0026] (2) The mosquito repellent and sunscreen cosmetic composition provided by the present invention comprises the following components in parts by weight: 3-5 parts of N,N-diethyl-2-hydroxy-2-phenylacetamide porous plant protein nanospheres, 1-3 parts of nano-hybrid hyperbranched polymer HB-TiO2, 0.8-1.2 parts of D-camphoric acid / terminated hydroxyl polyether condensate, 2-3 parts of traditional Chinese medicine extract, 0.1-0.3 parts of transdermal agent, 1-2 parts of plant extract, 40-60 parts of water, 3-5 parts of solubilizer, and 0.5-1 parts of natural emulsifier. The components work synergistically to overcome the defects of traditional mosquito repellent and sunscreen cosmetic compositions, such as single function, poor performance stability, and poor mosquito repellent and sunscreen effect. The resulting cosmetic has good sunscreen effect, good biocompatibility, no toxic side effects, and can whiten and moisturize the skin, and play an anti-aging, spot removal, and care role.

[0027] (3) The mosquito repellent and sun protection cosmetic composition provided by the present invention has the synergistic effect of D-camphoric acid / terminated hydroxyl polyether condensate, traditional Chinese medicine extract and plant extract, which makes the cosmetic have a significant sun protection effect; and it has good skin compatibility, no toxic side effects, and long-lasting high comfort.

[0028] (4) The mosquito repellent and sun protection cosmetic composition provided by the present invention uses plant protein to encapsulate the active ingredients in nano-microcapsule technology, which increases compatibility, affinity and friendliness, prevents allergies and skin incompatibility; the nano-hybrid hyperbranched polymer HB-TiO2 combines inorganic sun protection active ingredients, and the surface is modified by hyperbranched polymer, which makes its dispersibility better and helps to improve stability.

[0029] (5) The mosquito repellent and sun protection cosmetic composition provided by the present invention is made from the following raw materials in parts by weight: 1-4 parts of Artemisia argyi, 2-3 parts of white pomegranate, 2-4 parts of calamus, 2-3 parts of bitter melon, 1-3 parts of astaxanthin, 2-5 parts of dandelion, 1-4 parts of calendula, 1-3 parts of peppermint, 3-5 parts of red clover, 3-6 parts of Isatis indigotica, and 1-3 parts of verbena. The synergistic effect of each raw material makes the cosmetic not only have a good sun protection effect, but also have the effects of whitening, moisturizing, removing spots, and anti-aging. Detailed Implementation

[0030] The following description is intended to disclose the invention and enable those skilled in the art to implement it. The preferred embodiments described below are merely examples, and other obvious variations will occur to those skilled in the art.

[0031] The main preparation method of the N,N-diethyl-2-hydroxy-2-phenylacetamide porous plant protein nanospheres described in this embodiment of the invention is the same as that in Chinese Invention Patent Example 1 with application number 201310380795.9, with the addition of N,N-diethyl-2-hydroxy-2-phenylacetamide as the active ingredient; the preparation method of the nano-hybrid hyperbranched polymer HB-TiO2 is basically the same as that in Chinese Invention Patent Example 1 with application number 201910425260.6, except that nano-titanium dioxide is used instead of nano-silica. The decoction temperature is 95℃.

[0032] Example 1

[0033] A mosquito repellent and sunscreen cosmetic composition, characterized in that it comprises the following components in parts by weight: 3 parts of N,N-diethyl-2-hydroxy-2-phenylacetamide porous plant protein nanospheres, 1 part of nano-hybrid hyperbranched polymer HB-TiO2, 0.8 parts of D-camphoric acid / terminated hydroxyl polyether condensate, 2 parts of traditional Chinese medicine extract, 0.1 parts of transdermal agent, 1 part of plant extract, 40 parts of water, 3 parts of solubilizer, and 0.5 parts of natural emulsifier.

[0034] The solubilizer is glycerin; the plant extract is a mixture of cabbage extract and broccoli extract in a mass ratio of 3:5; the specifications of the plant extract are 10:1 and the particle size is 80 mesh; the transdermal agent is borneol; and the natural emulsifier is lecithin.

[0035] The herbal extract is made from the following raw materials in parts by weight: 1 part mugwort, 2 parts white pomegranate, 2 parts calamus, 2 parts bitter melon, 1 part astaxanthin, 2 parts dandelion, 1 part calendula, 1 part peppermint, 3 parts red clover, 3 parts indigo leaves, and 1 part verbena.

[0036] The preparation method of the herbal extract includes the following steps: mixing the raw materials according to the weight parts to obtain a mixed material, then decocting the mixed material in water for 1 hour, filtering, rotary evaporation to concentrate, vacuum filtering, and drying to obtain the herbal extract; the mass ratio of the mixed material to water is 1:4.

[0037] The preparation method of the D-camphoric acid / hydroxyl-terminated polyether condensate includes the following steps: D-camphoric acid and hydroxyl-terminated polyether are added to a high-boiling-point solvent and stirred until homogeneous to form a solution. Then, (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride) and N-hydroxysuccinimide are added to the solution, and the mixture is stirred at 110°C for 8 hours. The solvent is then removed by rotary evaporation, the solution is washed with diethyl ether, and dried at 85°C in a vacuum drying oven to constant weight to obtain the D-camphoric acid / hydroxyl-terminated polyether condensate. The molar ratio of D-camphoric acid, hydroxyl-terminated polyether, high-boiling-point solvent, (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride), and N-hydroxysuccinimide is 1:1:6:0.8:0.5. The high-boiling-point solvent is dimethyl sulfoxide.

[0038] A method for preparing the mosquito repellent and sunscreen cosmetic composition, characterized by comprising the following steps: mixing each component evenly according to the weight parts, stirring at 800 r / min for 25 min to obtain the mosquito repellent and sunscreen cosmetic composition.

[0039] Example 2

[0040] A mosquito repellent and sunscreen cosmetic composition, characterized in that it comprises the following components in parts by weight: 3.5 parts of N,N-diethyl-2-hydroxy-2-phenylacetamide porous plant protein nanospheres, 1.5 parts of nano-hybrid hyperbranched polymer HB-TiO2, 0.9 parts of D-camphoric acid / terminated hydroxyl polyether condensate, 2.3 parts of traditional Chinese medicine extract, 0.15 parts of transdermal agent, 1.2 parts of plant extract, 45 parts of water, 3.5 parts of solubilizer, and 0.6 parts of natural emulsifier.

[0041] The cosolvent is hyperbranched polyglycerol G4; the plant extract is a mixture of cabbage extract and broccoli extract in a mass ratio of 3:5; the specifications of the plant extract are 10:1 and the particle size is 85 mesh; the transdermal agent is peppermint oil; and the natural emulsifier is lanolin.

[0042] The herbal extract is made from the following raw materials in parts by weight: 2 parts Artemisia argyi, 2.3 parts white pomegranate, 2.5 parts calamus, 2.3 parts bitter melon, 1.5 parts astaxanthin, 2.5 parts dandelion, 2 parts calendula, 1.5 parts peppermint, 3.5 parts red clover, 4 parts Isatis tinctoria, and 1.5 parts verbena.

[0043] The method for preparing the herbal extract includes the following steps: mixing the raw materials according to their weight proportions to obtain a mixed medicinal material, then decocting the mixed medicinal material in water for 1.5 hours, filtering, rotary evaporation for concentration, vacuum filtration, and drying to obtain the herbal extract; the mass ratio of the mixed medicinal material to water is 1:5.

[0044] The preparation method of the D-camphoric acid / hydroxyl-terminated polyether condensate includes the following steps: D-camphoric acid and hydroxyl-terminated polyether are added to a high-boiling-point solvent and stirred until homogeneous to form a solution. Then, (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride) and N-hydroxysuccinimide are added to the solution, and the mixture is stirred at 120°C for 10 hours. The solvent is then removed by rotary evaporation, the solution is washed with diethyl ether, and dried at 87°C in a vacuum drying oven to constant weight to obtain the D-camphoric acid / hydroxyl-terminated polyether condensate. The molar ratio of D-camphoric acid, hydroxyl-terminated polyether, high-boiling-point solvent, (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride), and N-hydroxysuccinimide is 1:1:7:0.9:0.5. The high-boiling-point solvent is N,N-dimethylformamide.

[0045] A method for preparing the mosquito repellent and sunscreen cosmetic composition, characterized by comprising the following steps: mixing each component evenly according to the weight parts, stirring at 900 r / min for 28 min, to obtain the mosquito repellent and sunscreen cosmetic composition.

[0046] Example 3

[0047] A mosquito repellent and sunscreen cosmetic composition, characterized in that it comprises the following components in parts by weight: 3-5 parts of N,N-diethyl-2-hydroxy-2-phenylacetamide porous plant protein nanospheres, 2 parts of nano-hybrid hyperbranched polymer HB-TiO2, 1 part of D-camphoric acid / terminated hydroxyl polyether condensate, 2.5 parts of traditional Chinese medicine extract, 0.2 parts of transdermal agent, 1.5 parts of plant extract, 50 parts of water, 4 parts of solubilizer, and 0.8 parts of natural emulsifier.

[0048] The cosolvent is ethylene glycol; the plant extract is a mixture of cabbage extract and broccoli extract in a mass ratio of 3:5; the specifications of the plant extract are 10:1 and the particle size is 90 mesh; the transdermal agent is wintergreen oil; and the natural emulsifier is lanolin.

[0049] The herbal extract is made from the following raw materials in parts by weight: 3 parts Artemisia argyi, 2.5 parts white pomegranate, 3 parts calamus, 2.5 parts bitter melon, 2 parts astaxanthin, 3.5 parts dandelion, 2.5 parts calendula, 2 parts peppermint, 4 parts red clover, 4.5 parts Isatis tinctoria, and 2 parts verbena.

[0050] The method for preparing the herbal extract includes the following steps: mixing the raw materials according to their weight proportions to obtain a mixed medicinal material, then decocting the mixed medicinal material in water for 2 hours, filtering, rotary evaporation to concentrate, vacuum filtering, and drying to obtain the herbal extract; the mass ratio of the mixed medicinal material to water is 1:6.

[0051] The preparation method of the D-camphoric acid / hydroxyl-terminated polyether condensate includes the following steps: D-camphoric acid and hydroxyl-terminated polyether are added to a high-boiling-point solvent and stirred until homogeneous to form a solution. Then, (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride) and N-hydroxysuccinimide are added to the solution, and the mixture is stirred at 130°C for 13 hours. The solvent is then removed by rotary evaporation, the solution is washed with diethyl ether, and dried at 90°C in a vacuum drying oven to constant weight to obtain the D-camphoric acid / hydroxyl-terminated polyether condensate. The molar ratio of D-camphoric acid, hydroxyl-terminated polyether, high-boiling-point solvent, (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride), and N-hydroxysuccinimide is 1:1:8:1:0.5. The high-boiling-point solvent is N-methylpyrrolidone.

[0052] A method for preparing the mosquito repellent and sunscreen cosmetic composition, characterized by comprising the following steps: mixing each component evenly according to the weight parts, stirring at 950 r / min for 30 min, to obtain the mosquito repellent and sunscreen cosmetic composition.

[0053] Example 4

[0054] A mosquito repellent and sunscreen cosmetic composition, characterized in that it comprises the following components in parts by weight: 3.5 parts of N,N-diethyl-2-hydroxy-2-phenylacetamide porous plant protein nanospheres, 2.6 parts of nano-hybrid hyperbranched polymer HB-TiO2, 1.1 parts of D-camphoric acid / terminated hydroxyl polyether condensate, 2.8 parts of traditional Chinese medicine extract, 0.25 parts of transdermal agent, 1.8 parts of plant extract, 55 parts of water, 4.5 parts of solubilizer, and 0.9 parts of natural emulsifier.

[0055] The cosolvent is a mixture of glycerin, hyperbranched polyglycerol G4, and ethylene glycol in a mass ratio of 1:2:3; the plant extract is a mixture of cabbage extract and broccoli extract in a mass ratio of 3:5; the specifications of the plant extract are 10:1 and the particle size is 95 mesh; the transdermal agent is a mixture of borneol, peppermint oil, wintergreen oil, and clove oil in a mass ratio of 1:1:3:2; the natural emulsifier is a mixture of lecithin, lanolin, lanolin alcohol, lanolin acid, and beeswax in a mass ratio of 1:2:2:1:1.

[0056] The herbal extract is made from the following raw materials in parts by weight: 3.5 parts Artemisia argyi, 2.8 parts white pomegranate, 3.5 parts calamus, 2.8 parts bitter melon, 2.8 parts astaxanthin, 4.5 parts dandelion, 3.5 parts calendula, 2.5 parts peppermint, 4.5 parts red clover, 5 parts Isatis tinctoria, and 2.5 parts verbena.

[0057] The method for preparing the herbal extract includes the following steps: mixing the raw materials according to their weight proportions to obtain a mixed medicinal material, then decocting the mixed medicinal material in water for 2.5 hours, filtering, rotary evaporation for concentration, vacuum filtration, and drying to obtain the herbal extract; the mass ratio of the mixed medicinal material to water is 1:7.5.

[0058] The preparation method of the D-camphoric acid / hydroxyl-terminated polyether condensate includes the following steps: D-camphoric acid and hydroxyl-terminated polyether are added to a high-boiling-point solvent and stirred until homogeneous to form a solution. Then, (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride) and N-hydroxysuccinimide are added to the solution, and the mixture is stirred and reacted at 140°C for 15 hours. The solvent is then removed by rotary evaporation, washed with diethyl ether, and dried at 93°C in a vacuum drying oven to constant weight to obtain the D-camphoric acid / hydroxyl-terminated polyether condensate. The molar ratio of D-camphoric acid, hydroxyl-terminated polyether, high-boiling-point solvent, (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride), and N-hydroxysuccinimide is 1:1:9:1.1:0.5. The high-boiling-point solvent is a mixture of dimethyl sulfoxide, N,N-dimethylformamide, and N-methylpyrrolidone in a mass ratio of 1:3:5.

[0059] A method for preparing the mosquito repellent and sunscreen cosmetic composition, characterized by comprising the following steps: mixing each component evenly according to the weight parts, stirring at 1000 r / min for 33 min, to obtain the mosquito repellent and sunscreen cosmetic composition.

[0060] Example 5

[0061] A mosquito repellent and sunscreen cosmetic composition, characterized in that it comprises the following components in parts by weight: 5 parts of N,N-diethyl-2-hydroxy-2-phenylacetamide porous plant protein nanospheres, 3 parts of nano-hybrid hyperbranched polymer HB-TiO2, 1.2 parts of D-camphoric acid / terminated hydroxyl polyether condensate, 3 parts of traditional Chinese medicine extract, 0.3 parts of transdermal agent, 2 parts of plant extract, 60 parts of water, 5 parts of solubilizer, and 1 part of natural emulsifier.

[0062] The solubilizer is glycerin; the plant extract is a mixture of cabbage extract and broccoli extract in a mass ratio of 3:5; the specifications of the plant extract are 10:1 and the particle size is 100 mesh; the transdermal agent is clove oil; and the natural emulsifier is lecithin.

[0063] The herbal extract is made from the following raw materials in parts by weight: 4 parts Artemisia argyi, 3 parts white pomegranate, 4 parts calamus, 3 parts bitter melon, 3 parts astaxanthin, 5 parts dandelion, 4 parts calendula, 3 parts peppermint, 5 parts red clover, 6 parts Isatis indigotica, and 3 parts verbena.

[0064] The method for preparing the herbal extract includes the following steps: mixing the raw materials according to their weight proportions to obtain a mixed medicinal material, then decocting the mixed medicinal material in water for 3 hours, filtering, rotary evaporation to concentrate, vacuum filtering, and drying to obtain the herbal extract; the mass ratio of the mixed medicinal material to water is 1:8.

[0065] The preparation method of the D-camphoric acid / hydroxyl-terminated polyether condensate includes the following steps: D-camphoric acid and hydroxyl-terminated polyether are added to a high-boiling-point solvent and stirred until homogeneous to form a solution. Then, (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride) and N-hydroxysuccinimide are added to the solution, and the mixture is stirred at 150°C for 16 hours. The solvent is then removed by rotary evaporation, the solution is washed with diethyl ether, and dried at 95°C in a vacuum drying oven to constant weight to obtain the D-camphoric acid / hydroxyl-terminated polyether condensate. The molar ratio of D-camphoric acid, hydroxyl-terminated polyether, high-boiling-point solvent, (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride), and N-hydroxysuccinimide is 1:1:10:1.2:0.5. The high-boiling-point solvent is dimethyl sulfoxide.

[0066] A method for preparing the mosquito repellent and sunscreen cosmetic composition, characterized by comprising the following steps: mixing each component evenly according to the weight parts, stirring at 1100 r / min for 35 min, to obtain the mosquito repellent and sunscreen cosmetic composition.

[0067] Comparative Example 1

[0068] This example provides a mosquito-repellent and sunscreen cosmetic composition, whose formulation and preparation method are basically the same as those of Example 1, except that N,N-diethyl-2-hydroxy-2-phenylacetamide porous plant protein nanospheres and nano-hybrid hyperbranched polymer HB-TiO2 are not added.

[0069] Comparative Example 2

[0070] This example provides a mosquito-repellent and sunscreen cosmetic composition, whose formulation and preparation method are basically the same as those of Example 1, except that D-camphoric acid / terminal hydroxyl polyether condensate is not added.

[0071] Comparative Example 3

[0072] This example provides a mosquito-repellent and sunscreen cosmetic composition, whose formulation and preparation method are basically the same as those of Example 1, except that plant extracts and Chinese herbal extracts are not added.

[0073] Comparative Example 4

[0074] This example provides a comparative example of a common sunscreen lotion (purchase channel: Alibaba procurement network, Guangdong G Makeup Net Preparation No. 2019203***, a certain cosmetics company in Guangzhou)

[0075] In order to further illustrate the beneficial technical effects of the embodiments of the present invention, performance tests were carried out on the mosquito-repellent and sunscreen cosmetic compositions of each example. The test method can be found in the patent document with the application number 202010118276.5. The experimental results are shown in Table 1. Among them, for the comfort, skin whitening and moisturizing, anti-aging, freckle removal, and nursing effects after application, 20 volunteers were selected in each group for comprehensive scoring, and the average score of the volunteers in each group was taken as the score of this group; the scoring standard was from 0 to 5 points, and the higher the score, the better the comprehensive effects of comfort, skin whitening and moisturizing, anti-aging, and freckle removal and nursing.

[0076] Table 1

[0077] ItemSPF valuePA valueComfortMosquito repellent rate %Example 166.520.04.898Example 267.220.54.999Example 368.021.14.999Example 468.721.95.0100Example 569.322.55.0100Comparative Example 116.39.03.515Comparative Example 257.19.23.393Comparative Example 355.98.43.091Comparative Example 456.08.83.212

[0078] As can be seen from Table 1, the mosquito repellent and sunscreen cosmetic composition disclosed in the embodiments of the present invention has an SPF value ≥ 66.5, while the comparative example has ≤ 57.1, and a PA value ≥ 20.0, while the comparative example has ≤ 9. Furthermore, it scores higher in terms of comfort, skin whitening and moisturizing, anti-aging, freckle removal, and overall skincare effects. It is evident that the mosquito repellent and sunscreen cosmetic composition disclosed in the embodiments of the present invention has a significantly better clinical improvement effect than the comparative example. This is the result of the synergistic effect of N,N-diethyl-2-hydroxy-2-phenylacetamide porous plant protein nanospheres, nano-hybrid hyperbranched polymer HB-TiO2, D-camphoric acid / terminated hydroxyl polyether condensate, plant extracts, and traditional Chinese medicine extracts.

[0079] The above description is only a partial embodiment of the present invention. It should be noted that those skilled in the art can make several improvements without departing from the principle of the present invention, and these improvements should be considered within the scope of protection of the present invention.

Claims

1. A mosquito repellent and sunscreen cosmetic composition, characterized in that, The product comprises the following components in parts by weight: 3-5 parts of N,N-diethyl-2-hydroxy-2-phenylacetamide porous plant protein nanospheres, 1-3 parts of nano-hybrid hyperbranched polymer HB-TiO2, 0.8-1.2 parts of D-camphoric acid / terminated hydroxyl polyether condensate, 2-3 parts of traditional Chinese medicine extract, 0.1-0.3 parts of transdermal agent, 1-2 parts of plant extract, 40-60 parts of water, 3-5 parts of solubilizer, and 0.5-1 part of natural emulsifier; The plant extract is a mixture of cabbage extract and broccoli extract in a mass ratio of 3:

5. The herbal extract is made from the following raw materials in parts by weight: 1-4 parts of Artemisia argyi, 2-3 parts of white pomegranate, 2-4 parts of calamus, 2-3 parts of bitter melon, 1-3 parts of astaxanthin, 2-5 parts of dandelion, 1-4 parts of calendula, 1-3 parts of peppermint, 3-5 parts of red clover, 3-6 parts of Isatis indigotica, and 1-3 parts of verbena.

2. The mosquito repellent and sunscreen cosmetic composition according to claim 1, characterized in that, The cosolvent is at least one of glycerol, hyperbranched polyglycerol G4, and ethylene glycol.

3. The mosquito repellent and sunscreen cosmetic composition according to claim 1, characterized in that, The plant extract has a ratio of 10:1 and a particle size of 80-100 mesh.

4. The mosquito repellent and sunscreen cosmetic composition according to claim 1, characterized in that, The transdermal agent is at least one of borneol, peppermint oil, wintergreen oil, and clove oil; the natural emulsifier is at least one of lecithin, lanolin, lanolin alcohol, lanolin acid, and beeswax.

5. The mosquito repellent and sunscreen cosmetic composition according to claim 1, characterized in that, The preparation method of the herbal extract includes the following steps: mixing the raw materials according to the weight parts to obtain a mixed material, then decocting the mixed material in water for 1-3 hours, filtering, rotary evaporation to concentrate, vacuum filtering, and drying to obtain the herbal extract.

6. The mosquito repellent and sunscreen cosmetic composition according to claim 5, characterized in that, The mass ratio of the mixed medicine to water is 1:(4-8).

7. The mosquito repellent and sunscreen cosmetic composition according to claim 1, characterized in that, The method for preparing the N,N-diethyl-2-hydroxy-2-phenylacetamide porous plant protein nanospheres is as follows: gelatin and nano-plant protein are mixed at a mass ratio of 2:1 and dissolved in distilled water at 60°C. N,N-diethyl-2-hydroxy-2-phenylacetamide is mixed with the above solution at a mass ratio of 1:

10. The mixture is stirred at a low temperature of 35°C and 280-450 r / min for 3-4.5 h. After cooling to room temperature, a dispersant is added. The mixture is then washed with water, filtered, air-dried, and ultra-finely pulverized to obtain the final product. The method for preparing the nano-plant protein is as follows: plant cellulose and distilled water are mixed at a mass ratio of 1:10 to 1:20, and ultrasonicated at a power of 2500W and an oscillation frequency of 28kHz for 4 hours. Then, anhydrous ethanol is added at -20℃ to -5℃, and the mixture is freeze-dried and pulverized to obtain nano-plant protein.

8. The mosquito repellent and sunscreen cosmetic composition according to claim 1, characterized in that, The preparation method of the D-camphoric acid / hydroxyl-terminated polyether condensate includes the following steps: D-camphoric acid and hydroxyl-terminated polyether are added to a high-boiling-point solvent and stirred until homogeneous to form a solution. Then, (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride) and N-hydroxysuccinimide are added to the solution. The mixture is stirred and reacted at 110-150℃ for 8-16 hours. The solvent is then removed by rotary evaporation, the mixture is washed with diethyl ether, and dried in a vacuum drying oven at 85-95℃ to constant weight to obtain the D-camphoric acid / hydroxyl-terminated polyether condensate.

9. The mosquito repellent and sunscreen cosmetic composition according to claim 8, characterized in that, The molar ratio of D-camphoric acid, hydroxyl-terminated polyether, high-boiling-point solvent, (1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride), and N-hydroxysuccinimide is 1:1:(6-10):(0.8-1.2):0.5; the high-boiling-point solvent is at least one of dimethyl sulfoxide, N,N-dimethylformamide, and N-methylpyrrolidone.

10. A method for preparing a mosquito-repellent and sunscreen cosmetic composition according to any one of claims 1-8, characterized in that, The process includes the following steps: mixing each component according to its weight proportions until homogeneous, and stirring at 800-1100 r / min for 25-35 min to obtain a mosquito repellent and sunscreen cosmetic composition.