Biological-sample rapid testing device

Abstract

The present disclosure relates to the field of biological-sample testing. Disclosed is a biological-sample rapid testing device, which is used for conveniently and accurately injecting samples into reaction tanks. The biological-sample rapid testing device comprises a cover, a cylinder and a biological-sample accommodating body, wherein the cylinder comprises a mounting cavity and a plurality of reaction tanks, each reaction tank being in communication with the mounting cavity; the cover is detachably mounted at a top opening of the mounting cavity; and the biological-sample accommodating body is removably located inside the mounting cavity and comprises a sample tank, a liquid discharge pipe and an exhaust flow channel, one end of the liquid discharge pipe being in communication with the sample tank, the other end of the liquid discharge pipe being in communication with the reaction tanks, one end of the exhaust flow channel being in communication with the reaction tanks, and the other end of the exhaust flow channel extending to the top face of the biological-sample accommodating body. By means of the solution, a biological sample can be injected into a reaction tank without requiring other containers, biological samples can be injected into a plurality of reaction tanks in one step by means of flow splitting, the injection quantity is accurate and controllable, and the injection efficiency is high.

Description

A rapid detection device for biological samples

[0001] CROSS-REFERENCE TO RELATED APPLICATIONS

[0002] This disclosure is based on and claims priority to CN application No. 202410482090.6 filed on April 22, 2024, the contents of which are incorporated herein by reference in their entirety. Technical Field

[0003] This disclosure relates to the field of biological sample detection, specifically to a rapid detection device for biological samples. Background Technology

[0004] In vitro diagnostics, or IVD for short, refers to products and services that obtain clinical diagnostic information by testing biological samples (blood, body fluids, tissues, etc.) outside of the organism, thereby determining diseases or bodily functions.

[0005] The inventors have discovered that existing technologies suffer from at least the following problems: In vitro diagnostic processes are highly complex, involving numerous steps and demanding high standards for the testing environment, laboratory conditions, and the technical skills of personnel. During the diagnostic process, to inject samples or other liquids into the reaction chamber or pretreatment chamber, tools such as pipettes and tubes are needed to guide the sample solution into different reaction chambers or pretreatment chambers for the detection of multiple indicators. In this process, solution leakage or operational errors are prone to occur, affecting the reaction conditions within the target chamber and thus the test results. Summary of the Invention

[0006] This disclosure proposes a rapid detection device for biological samples, which facilitates and accurately injects samples into a reaction tank.

[0007] This disclosure provides a rapid detection device for biological samples, comprising:

[0008] Cover;

[0009] A cylindrical body includes a mounting cavity and a reaction tank located at the bottom of the mounting cavity; the number of reaction tanks is at least two, and each reaction tank communicates with the mounting cavity; a cover is detachably installed at the top opening of the mounting cavity to seal the mounting cavity; and

[0010] The biological sample container is removably located inside the mounting cavity; the biological sample container includes a sample pool, a drain pipe disposed at the bottom of the sample pool and extending toward the outside of the biological sample container, and an exhaust channel penetrating the inner wall of the biological sample container; one end of the drain pipe is connected to the sample pool, and the other end of the drain pipe is connected to the reaction pool; one end of the exhaust channel is connected to the reaction pool, and the other end of the exhaust channel extends to the top surface of the biological sample container.

[0011] In some embodiments, the biological sample accommodating body includes:

[0012] The main body is provided with the sample pool; and

[0013] Multiple separate protrusions are provided, each of which is located at the bottom of the main body; each protrusion is provided in a one-to-one correspondence with a reaction tank, each protrusion is inserted into the top of one of the reaction tanks, and there is a gap between the bottom wall of the protrusion and the bottom wall of the corresponding reaction tank; the inner wall of the top of each reaction tank is engaged with the outer wall of the corresponding protrusion.

[0014] The drain pipe passes through the protrusion and is connected to the sample pool; the exhaust channel passes through the wall of the main body and the protrusion.

[0015] In some embodiments, each of the exhaust channels extends through the body portion and one of the protrusions located at the bottom of the body portion.

[0016] In some embodiments, the cylindrical body further includes a guide block, which is installed on the inner wall of the mounting cavity; the outer wall of the biological sample accommodating body is provided with a guide groove; the guide block is inserted into the guide groove; or, the inner wall of the cylindrical body is provided with a guide groove; the outer wall of the biological sample accommodating body is provided with a guide block; the guide block is inserted into the guide groove.

[0017] In some embodiments, multiple guide blocks and multiple guide grooves are arranged at intervals along the axial direction of the cylinder, with each guide block and guide groove corresponding to the other.

[0018] In some embodiments, the biological sample accommodating body further includes:

[0019] A plurality of first seals are provided, with at least one first seal mounted on the outer wall of each of the protrusions; the first seals form a sealed connection between the outer wall of the protrusion and the inner wall of the reaction vessel accommodating the protrusion.

[0020] In some embodiments, the rapid detection device for biological samples further includes:

[0021] Multiple second seals are provided, with a second seal installed on the top of each of the exhaust channels, and the second seals form a sealing connection with the bottom surface of the cover.

[0022] In some embodiments, the rapid detection device for biological samples further includes:

[0023] The third sealing element is installed on the top of the biological sample container body and is located outside all the exhaust channels; the third sealing element forms a sealed connection with the bottom surface of the cover.

[0024] In some embodiments, the cylindrical body includes:

[0025] The cylindrical portion includes the mounting cavity; the main body portion is mounted in the mounting cavity of the cylindrical portion; and

[0026] Multiple protrusions are located at the bottom of the cylindrical portion and are fixedly connected to the cylindrical portion; the protrusions are spaced apart; each protrusion protrudes away from the top of the cylindrical portion; each protrusion is provided with a reaction tank.

[0027] In some embodiments, the cylindrical body further includes:

[0028] A baffle plate is fixed to the bottom of the side wall of the cylinder and located on the outer periphery of the reaction tank to prevent it from touching the outer wall of the reaction tank.

[0029] In some embodiments, the cover includes:

[0030] The cover body is detachably connected to the cylinder body; and

[0031] A column is fixedly connected to the cover body, and one end of the column is fixedly connected to the middle position of the cover body. The length of the column is greater than the height of the cover body.

[0032] When the cover and the cylinder are installed in place, the other end of the column away from the cover body abuts against the top opening of the drain pipe.

[0033] In some embodiments, the drain pipe is connected to the reaction tank in a one-to-one correspondence; and / or, the exhaust channel is connected to the reaction tank in a one-to-one correspondence.

[0034] In some embodiments, the cylindrical body further includes:

[0035] An anti-slip part is provided on the outer wall of the cylinder.

[0036] In some embodiments, different types of detection substances are pre-placed inside each of the reaction cells; and / or, the number of reaction cells is 2 to 16.

[0037] In some embodiments, the volumes of each of the reaction tanks are equal.

[0038] The rapid biological sample detection device provided by the above technical solution includes a cover, a cylinder, and a biological sample container body. Biological samples are injected into various reaction chambers through the sample pool of the biological sample container body. During manufacturing, the volume of each reaction chamber can be directly manufactured to a predetermined volume. When sample solution is subsequently delivered from the sample chamber to the reaction chamber, any portion exceeding the reaction chamber's volume cannot be delivered. Furthermore, sample solution can be delivered to multiple reaction chambers simultaneously through a single sample chamber. The rapid biological sample detection device provided in some embodiments of this disclosure not only eliminates the need for other containers to inject biological samples into the reaction chambers but also allows for the simultaneous injection of biological samples into multiple reaction chambers through diversion. The sample volume injected into each reaction chamber is precisely controllable, resulting in accurate and efficient injection. Attached Figure Description

[0039] Figure 1 is an exploded structural diagram of a rapid biological sample detection device provided in some embodiments of this disclosure.

[0040] Figure 2 is a schematic diagram of the exploded structure of the cover and the biological sample container of the rapid detection device for biological samples provided in some embodiments of this disclosure.

[0041] Figure 3 is a schematic diagram of the disassembled structure of the cylindrical body of the rapid biological sample detection device provided in some embodiments of this disclosure.

[0042] Figure 4 is a cross-sectional three-dimensional structural diagram of a rapid biological sample detection device provided in some embodiments of this disclosure.

[0043] Figure 5 is a cross-sectional front view of the rapid biological sample detection device provided in some embodiments of this disclosure.

[0044] Figure 6 is a schematic diagram of the cylindrical structure of a rapid biological sample detection device provided in some embodiments of this disclosure.

[0045] Figure 7 is a three-dimensional structural schematic diagram of a rapid biological sample detection device provided in some other embodiments of this disclosure.

[0046] Figure 8 is a three-dimensional structural schematic diagram of a rapid biological sample detection device provided in some embodiments of this disclosure.

[0047] Figure 9 is an exploded structural diagram of a rapid biological sample detection device provided in some other embodiments of this disclosure.

[0048] Figure 10 is a cross-sectional schematic diagram of a rapid biological sample detection device provided in some other embodiments of this disclosure.

[0049] Reference numerals: 1. Cover; 2. Cylinder; 3. Biological sample container; 4. Guide block; 5. Guide groove; 6. First seal; 7. Second seal; 8. Third seal; 9. Detection substance; 11. Cover body; 12. Column; 13. Bottom surface; 20. Positioning protrusion; 21. Mounting cavity; 22. Reaction cell; 23. Cylindrical part; 24. Protrusion; 25. Baffle plate; 26. Anti-slip part; 31. Sample cell; 32. Drain pipe; 33. Exhaust channel; 34. Main body; 35. Protrusion. Detailed Implementation

[0050] The technical solutions provided in this disclosure will be described in more detail below with reference to Figures 1 to 10. The descriptions of exemplary embodiments are merely illustrative and are in no way intended to limit this disclosure or its application or use. This disclosure can be implemented in many different forms and is not limited to the embodiments described herein. These embodiments are provided to make this disclosure thorough and complete, and to fully express the scope of this disclosure to those skilled in the art. It should be noted that, unless otherwise specifically stated, the relative arrangement of components and steps, the composition of materials, numerical expressions, and values ​​set forth in these embodiments should be interpreted as merely exemplary and not as limiting.

[0051] The terms “first,” “second,” and similar words used in this disclosure do not indicate any order, quantity, or importance, but are merely used to distinguish different parts. Words such as “including” or “contains” mean that the element preceding the word covers the element listed after the word, and do not exclude the possibility of covering other elements as well.

[0052] In the description of this disclosure, it should be understood that the terms "center", "longitudinal", "lateral", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate the orientation or positional relationship based on the orientation or positional relationship shown in the accompanying drawings, and are only for the convenience of describing this disclosure and simplifying the description, and do not indicate or imply that the device or element referred to must have a specific orientation, or be constructed and operated in a specific orientation, and therefore should not be construed as a limitation on the scope of protection of this disclosure.

[0053] In this disclosure, when a specific device is described as being located between a first device and a second device, an intermediary device may or may not be present between the specific device and the first or second device. When a specific device is described as being connected to other devices, the specific device may be directly connected to the other devices without an intermediary device, or it may be not directly connected to the other devices but have an intermediary device.

[0054] All terms used in this disclosure (including technical or scientific terms) have the same meaning as understood by one of ordinary skill in the art to which this disclosure pertains, unless otherwise specifically defined. It should also be understood that terms defined in a general dictionary, such as a dictionary, should be interpreted as having a meaning consistent with their meaning in the context of the relevant art, and not as having an idealized or highly formalized meaning, unless expressly defined herein.

[0055] Techniques, methods, and equipment known to those skilled in the art may not be discussed in detail, but where appropriate, such techniques, methods, and equipment should be considered part of the specification.

[0056] The dimensions of the various parts shown in the accompanying drawings are not drawn to actual scale. Common structural elements or elements of the same kind are given the same reference numerals in the various drawings, and repeated descriptions of them are omitted where appropriate.

[0057] Referring to Figures 1 and 2, some embodiments of this disclosure provide a rapid detection device for biological samples, including a cover 1, a cylinder 2, and a biological sample container body 3. Referring to Figures 3 to 5, the cylinder 2 includes an installation cavity 21 and a reaction pool 22 located at the bottom of the installation cavity 21; the number of reaction pools 22 is at least two, and each reaction pool 22 is in communication with the installation cavity 21; the cover 1 is detachably installed at the top opening of the installation cavity 21 to seal the installation cavity 21. Referring to Figures 2 and 4, the biological sample container body 3 is removably located inside the installation cavity 21; the biological sample container body 3 includes a sample pool 31, a drain pipe 32 disposed at the bottom of the sample pool 31 and extending toward the outside of the biological sample container body 3, and an exhaust channel 33 penetrating the inner wall of the biological sample container body 3. One end of the drain pipe 32 is connected to the sample pool 31, and the other end of the drain pipe 32 is connected to the reaction pool 22; one end of the exhaust channel 33 is connected to the reaction pool 22, and the other end of the exhaust channel 33 extends to the top surface of the biological sample container body 3.

[0058] The above technical solution eliminates the need for additional pipettes or tubes to transfer liquid from the sample pool 31. Gravity automatically directs the sample from the sample pool 31 into the reaction pool 22, completing the liquid injection operation. This reduces the risk of errors associated with using additional pipettes or tubes, and lowers the overall operational risk. During the detection process, the sample pool 31 and reaction pool 22 remain completely sealed, preventing the reaction liquid and aerosols generated during the reaction from leaking into the air and minimizing environmental pollution.

[0059] Referring to Figures 1 and 3, the top of the cylinder 2 is open, and the bottom is closed. The cover 1 fits into the top of the cylinder 2, sealing the open top of the mounting cavity 21 of the cylinder 2. The cover 1 and the cylinder 2 are detachably connected, specifically by threaded connection, snap-fit, or elastic sleeve. In some embodiments, the outer side wall of the cover 1 has anti-slip protrusions to facilitate disassembly and installation. In the installed state, the inner wall of the bottom surface 13 of the cover 1 abuts against the top surface of the biological sample receiving body 3 to prevent the biological sample receiving body 3 from shaking within the mounting cavity 21, ensuring normal operation of the detection process.

[0060] Referring again to Figures 1 and 3, the biological sample container body 3 includes a main body 34 and multiple separate protrusions 35. The main body 34 is provided with a sample pool 31. Each protrusion 35 corresponds to a reaction pool 22. The cylindrical body 2 includes a cylindrical portion 23 and multiple protrusions 24. The cylindrical portion 23 includes a mounting cavity 21. The main body 34 is mounted in the mounting cavity 21 of the cylindrical portion 23. Multiple protrusions 24 are located at the bottom of the cylindrical portion 23 and are fixedly connected to it; the protrusions 24 are spaced apart; each protrusion 24 protrudes away from the top of the cylindrical portion 23; each protrusion 24 is provided with a reaction pool 22. Figure 1 clearly shows that multiple separate protrusions 24 are provided at the bottom of the cylindrical portion 23. In some embodiments, 2 to 16 protrusions 24 are used as an example. Each protrusion 24 is provided with a reaction pool 22. Of course, in other embodiments, each protrusion 24 is provided with two or even more reaction pools 22. Figure 1 shows an example with four protrusions 24, each protrusion 24 being provided with one reaction pool 22. The cross-sectional view in Figure 6 clearly illustrates the structure of the protrusions 24 and the reaction pools 22.

[0061] Referring to Figure 6, the interior of each protrusion 24 is hollow, and the hollow area serves as the reaction chamber 22. To better mate with the protrusions 35 at the bottom of the biological sample container 3, the top of each protrusion 24 extends upward into the mounting cavity 21, while the bottom of the protrusion 24 protrudes downward from the mounting cavity 21. The top of the protrusion 24 is open, and the bottom is closed. The reaction chamber 22 is divided into upper and lower sections. The upper section is used to fit against the protrusions 35 at the bottom of the biological sample container 3, forming a sealed contact; the lower section of the reaction chamber 22 serves as the reaction area. To simultaneously limit the bottom wall of the main body 34 of the biological sample container 3 (described in detail later), a positioning protrusion 20 protruding towards the inner wall of the reaction chamber 22 is provided in the connecting area between the upper and lower sections of the reaction chamber 22. After the biological sample container 3 is installed in the mounting cavity 21, the bottom wall of the main body 34 of the biological sample container 3 will abut against the positioning protrusion 20. This structure does not increase the structural size of the cylinder 2 itself. The positioning protrusion 20 is formed directly by the interface between the upper and lower sections of the reaction tank 22. The structure is ingenious, and the product size is smaller and lighter.

[0062] In some embodiments, the volumes of each reaction tank 22 are equal. The volumes of each reaction tank 22 are designed to be identical, and the volume of liquid injected into each reaction tank 22 is also the same. The reactions in each reaction tank 22 occur simultaneously, thus enabling quantitative batch testing and greatly improving experimental efficiency. In other embodiments, different types of detection substances 9 are pre-placed in each reaction tank 22 to conduct multiple different tests simultaneously. Detection substances 9 include substances of various forms, such as lyophilized bulbs, lyophilized powders, and colloidal blocks.

[0063] Referring to Figures 1, 2, and 4, the biological sample container 3 is placed between the cover 1 and the cylinder 2, and is located inside the mounting cavity 21. The biological sample container 3 and the cylinder 2 can be separate or connected together. In embodiments where the biological sample container 3 and the cylinder 2 are connected, they are connected by methods such as elastic sleeve, snap-fit, threaded connection, ultrasonic welding, or laser welding. After the cover 1 is installed at the opening of the cylinder 2, the biological sample container 3 is confined between the cover 1 and the cylinder 2 and will not fall off. The biological sample container 3 is sealed, preventing substances inside the biological sample container 3 from flowing out of the biological sample rapid detection device, and also preventing substances outside the biological sample rapid detection device from entering the interior of the biological sample container 3.

[0064] Referring again to Figures 1, 2, and 4, the biological sample container 3 includes a main body 34 and multiple separate protrusions 35. A sample pool 31 is disposed on the main body 34. Each protrusion 35 is disposed at the bottom of the main body 34. Each protrusion 35 corresponds to a reaction pool 22, with each protrusion 35 inserted into the top of one of the reaction pools 22, and a gap exists between the bottom wall of the protrusion 35 and the bottom wall of the corresponding reaction pool 22, providing space for the placement of the detection substance 9. The inner top wall of each reaction pool 22 mates with the outer wall of the corresponding protrusion 35. The installation relationship and relative positional relationship between each protrusion 35 and its corresponding reaction pool 22 are identical. A drain pipe 32 penetrates the protrusion 35 and communicates with the sample pool 31; an exhaust channel 33 penetrates the wall of the main body 34 and the protrusions 35.

[0065] Referring to Figure 1, taking one of the protrusions 35 as an example, this protrusion 35 is located on the bottom wall of the main body 34, protruding away from the top of the main body 34. Each protrusion 35 has two through-flow channels: one corresponding to the drain pipe 32, and the other corresponding to the exhaust channel 33. The drain pipe 32 is relatively long, passing through the protrusion 35 and extending into the lower middle part of the reaction tank 22, so that the sample in the sample tank 31 can easily enter the bottom of the reaction tank 22 along the drain pipe 32. The exhaust channel 33 only needs to connect to the top of the reaction tank 22, and should not extend into the interior of the reaction tank 22, to prevent liquid from entering the exhaust channel 33 when there is a lot of liquid in the reaction tank 22, thus obstructing the exhaust. By connecting the exhaust channel 33 to the top of the reaction tank 22 and not extending into the interior of the reaction tank 22, the gas in the reaction tank 22 and the gas generated during the reaction process can be effectively discharged.

[0066] Figures 1 and 4 clearly illustrate the arrangement of the exhaust channels 33. There are multiple exhaust channels 33, with each protrusion 35 corresponding to one exhaust channel 33. Each exhaust channel 33 penetrates both the main body 34 and one of the corresponding protrusions 35. In some embodiments of this disclosure, four protrusions 35 are used as an example, resulting in four exhaust channels 33. The four exhaust channels 33 are evenly distributed along the circumference of the main body 34. The exhaust channels 33 penetrate the wall of the main body 34, while the sample pool 31 is located in the middle region of the main body 34. The exhaust channels 33 and the sample pool 31 are separate and not directly connected.

[0067] In some embodiments, to enable more precise positioning and guidance when the biological sample container 3 is installed onto the cylinder 2, a guide component is provided between the inner wall of the cylinder 2 and the outside of the biological sample container 3. The guide component can be implemented in two specific ways.

[0068] The first type, referring to Figure 3, further includes guide blocks 4 mounted on the inner wall of the mounting cavity 21; referring to Figure 2, the outer wall of the main body 34 of the biological sample container 3 is provided with guide grooves 5; the guide blocks 4 are inserted into the guide grooves 5. The guide blocks 4 are elongated strip structures. Multiple guide blocks 4 can be arranged along the inner wall of the mounting cavity 21. The length of the guide blocks 4 is close to the length of the main body 34 of the biological sample container 3, and slightly shorter than the length of the main body 34 of the biological sample container 3. The length, number, and distribution of the guide grooves 5 correspond one-to-one with the guide blocks 4. When the biological sample container 3 is installed into the mounting cavity 21 of the cylindrical body 2, the cooperation of the guide blocks 4 and the guide grooves 5 allows the biological sample container 3 to be inserted into the mounting cavity 21 of the cylindrical body 2 in a linear motion.

[0069] As shown in Figures 2 and 3, multiple guide blocks 4 and multiple guide grooves 5 are arranged at intervals along the axial direction of the cylinder 2, with each guide block 4 and guide groove 5 corresponding to another. The cooperation of multiple sets of guide blocks 4 and guide grooves 5 makes the installation process of the biological sample container body 3 more stable and reliable.

[0070] In the second method, a guide groove 5 is provided on the inner wall of the cylinder 2; a guide block 4 is provided on the outer wall of the biological sample container 3; the guide block 4 is inserted into the guide groove 5. The second method interchanges the positions of the guide block 4 and the guide groove 5 with the first method, and the effect is similar.

[0071] It is understood that in some other embodiments, the cylindrical body 2 is provided with both guide blocks 4 and guide grooves 5, and correspondingly, guide blocks 4 and guide grooves 5 are also provided in the main body 34 of the biological sample receiving body 3. The guide blocks 4 of the cylindrical body 2 cooperate with the guide grooves 5 of the biological sample receiving body 3, and the guide grooves 5 of the cylindrical body 2 cooperate with the guide blocks 4 of the biological sample receiving body 3.

[0072] The sealing part is described below.

[0073] Referring to Figure 1, the biological sample container 3 also includes multiple first sealing elements 6, with at least one first sealing element 6 installed on the outer wall of each protrusion 35; the first sealing elements 6 form a sealed connection between the outer wall of the protrusion 35 and the inner wall of the reaction pool 22 that accommodates the protrusion 35. Specifically, the first sealing element 6 is a sealing ring, with one or more sealing rings provided on the outer wall of each protrusion 35. By providing the first sealing elements 6, the fluid in the sample pool 31 can only enter the reaction pool 22 through the drain pipe 32, and the fluid in the reaction pool 22 will not flow out of the reaction pool 22 along the gap between the wall of the reaction pool 22 and the wall of the protrusion 35.

[0074] Referring to Figure 2, the rapid biological sample detection device also includes multiple second seals 7. Each exhaust channel 33 has a second seal 7 installed at its top, and each exhaust channel 33 has one or more sealing rings around its top perimeter. The second seals 7 form a sealed connection with the bottom surface 13 of the cover 1. The second seals 7 are sealing rings. The second seals 7 are compressed by the bottom surface 13 of the cover 1 and the top surface of the main body 34. After the cover 1 and the biological sample container 3 are both in place, the second seals 7 prevent fluid in the exhaust channels 33 from overflowing from the top of the exhaust channels 33.

[0075] Referring again to Figure 2, the rapid biological sample detection device also includes a third seal 8, which is installed on top of the biological sample container body 3 and located outside all the exhaust channels 33; the third seal 8 forms a sealed connection with the bottom surface of the cover 1. The third seal 8 is located at the top edge of the main body 34. The third seal 8 is a sealing ring. The third sealing ring is squeezed by the inner side of the wall of the cover 1 and the top surface of the main body 34 to achieve a seal. The third seal 8 prevents the fluid in the sample pool 31 and the exhaust channels 33 from overflowing from the edge of the main body 34.

[0076] Referring to Figure 7, some other embodiments of the rapid biological sample detection device provided in this disclosure differ from the embodiments described above in that: the cylinder 2 further includes a baffle plate 25, which is fixed to the bottom of the side wall of the cylinder 2 and located on the outer periphery of the reaction tank 22 to prevent contact with the outer wall of the reaction tank 22. The baffle plate 25 and the cylinder 2 can be integral or fixedly connected, and there can be one or more baffle plates 25. The function of the baffle plate 25 is to prevent the operator's hand from touching the outer wall of the reaction tank 22, which could cause a change in the temperature of the reaction tank 22.

[0077] Referring to Figure 8, the rapid biological sample detection device provided in some embodiments of this disclosure differs from the embodiments described above in that the cylinder 2 further includes an anti-slip portion 26, which is disposed on the outer wall of the cylinder 2. The anti-slip portion 26 can specifically be plate-shaped, have a rough surface, or other anti-slip structure. In the embodiment shown in Figure 8, the anti-slip portion 26 is a strip-shaped plate. The function of the anti-slip portion 26 is to allow the operator to grip the cylinder 2 more firmly to prevent slippage. In other embodiments, the anti-slip portion 26 is also used as a limiting portion, which allows the rapid biological sample detection device to be accurately installed into the isothermal amplification detection device.

[0078] Referring to Figures 9 and 10, the rapid detection device for biological samples provided in some embodiments of this disclosure differs from the embodiments described above in that the structure of the cover 1 is different.

[0079] Specifically, the cover 1 includes a cover body 11 and a column 12. The cover body 11 is detachably connected to the cylinder 2. The column 12 is fixedly connected to the cover body 11, and one end of the column 12 is fixedly connected to the middle position of the cover body 11. The length of the column 12 is greater than the height of the cover body 11. When the cover 1 and the cylinder 2 are installed in place, the other end of the column 12 away from the cover body 11 abuts against the top opening of the drain pipe 32.

[0080] Once the cover 1 is in place, the column 12 rotates to face the top of the drain pipe 32. Under the pressure of the cover 1, the bottom end of the column 12 abuts against the top of the drain pipe 32, sealing the connection. This structure of the cover 1 isolates the liquid in the reaction tank 22 from the outside environment during the use of the rapid biological sample detection device, which helps improve the accuracy of the detection.

[0081] The rapid biological sample detection devices in the various embodiments described above all employ the following methods for detection.

[0082] Before testing, the test substance 9 is placed into the reaction tank 22; then the biological sample container 3 is installed inside the cylinder 2. The biological sample container 3 is inserted into the cylinder 2 through the guide groove 5 and the guide block 4. The first sealing element 6 is sealed to the top of the reaction tank 22, sealing off the other areas of the reaction tank 22. The drain pipe 32 and the exhaust channel 33 are both connected to the reaction tank 22.

[0083] Then, the sample solution to be tested in the sample pool 31, under the action of gravity, flows along the drain pipe 32 into the reaction pool 22, where it mixes with the pre-stored detection substance 9, allowing the sample solution to react with the detection substance 9 in the reaction pool 22. After the sample solution fills the reaction pool 22, according to the principle of the U-tube, under the action of gravity and capillary force, the sample solution continues to flow into the exhaust channel 33, partially or completely filling the exhaust channel 33 until the sample solution stops flowing. Then, the cover 1 is installed on the cylinder 2 to seal the cylinder 2 and the biological sample container body 3.

[0084] The cover 1 and the cylinder 2 are connected by threads, snap-fit, or elastic sleeve, so that the bottom surface 13 of the cover 1 presses against the second sealing element 7 and the third sealing element 8 to achieve a seal. In this way, the inlet of the sample pool 31 and the exhaust channel 33 can be sealed separately, which can prevent other internal environments within the reagent kit from affecting the reaction environment within the reaction pool 22, and can also prevent external environments from disrupting the reaction environment within the reaction pool 22, reducing or even preventing the reaction liquid within the reaction pool 22 from leaking into the air and causing environmental pollution.

[0085] The rapid biological sample detection device is then sent to the detection instrument for testing. During the detection process, the rapid biological sample detection device is heated to allow the mixed liquid in reaction cell 22 to react. Since sample cell 31 and reaction cell 22 are in a sealed state, no bubbles are generated in reaction cell 22 after heating, thus avoiding instability of the light signal caused by bubbles when the light signal passes through reaction cell 22 during the detection process.

[0086] Finally, it should be noted that the above embodiments are only used to illustrate the technical solutions of this disclosure and not to limit them; although this disclosure has been described in detail with reference to preferred embodiments, those skilled in the art should understand that modifications can still be made to the specific implementation of this disclosure or equivalent substitutions can be made to some technical features without departing from the spirit of the technical solutions of this disclosure, and all such modifications and substitutions should be covered within the scope of the technical solutions claimed in this disclosure.

Claims

1. A rapid detection device for biological samples, comprising: Cover (1); The cylindrical body (2) includes a mounting cavity (21) and a reaction tank (22) located at the bottom of the mounting cavity (21); the number of reaction tanks (22) is at least two, and each of the reaction tanks (22) is in communication with the mounting cavity (21); the cover (1) is detachably installed at the top opening of the mounting cavity (21) to seal the mounting cavity (21); and The biological sample container body (3) is removably located inside the mounting cavity (21); the biological sample container body (3) includes a sample pool (31), a drain pipe (32) disposed at the bottom of the sample pool (31) and extending toward the outside of the biological sample container body (3), and an exhaust channel (33) penetrating the inner wall of the biological sample container body (3); one end of the drain pipe (32) is connected to the sample pool (31), and the other end of the drain pipe (32) is connected to the reaction pool (22); one end of the exhaust channel (33) is connected to the reaction pool (22), and the other end of the exhaust channel (33) extends to the top surface of the biological sample container body (3).

2. The rapid detection device for biological samples according to claim 1, wherein the biological sample accommodating body (3) comprises: The main body (34) is provided with the sample pool (31); as well as Multiple separate protrusions (35) are provided at the bottom of the main body (34); each protrusion (35) is provided in a one-to-one correspondence with a reaction tank (22), each protrusion (35) is inserted into the top of one of the reaction tanks (22), and the bottom wall of the protrusion (35) has a gap with the bottom wall of the corresponding reaction tank (22); the inner wall of the top of each reaction tank (22) is engaged with the outer wall of the corresponding protrusion (35); The drain pipe (32) passes through the protrusion (35) and is connected to the sample pool (31); the exhaust channel (33) passes through the wall of the main body (34) and the protrusion (35).

3. The rapid biological sample detection device according to claim 2, wherein each of the exhaust channels (33) penetrates the main body (34) and one of the protrusions (35) located at the bottom of the main body (34).

4. The rapid biological sample detection device according to claim 2 or 3, wherein the cylindrical body (2) further includes a guide block (4), the guide block (4) is installed on the inner wall of the mounting cavity (21), the outer wall of the biological sample receiving body (3) is provided with a guide groove (5), and the guide block (4) is inserted into the guide groove (5); or, the inner wall of the cylindrical body (2) is provided with a guide groove (5), the outer wall of the biological sample receiving body (3) is provided with a guide block (4), and the guide block (4) is inserted into the guide groove (5).

5. The rapid biological sample detection device according to claim 4, wherein multiple guide blocks (4) and multiple guide grooves (5) are arranged at intervals along the axial direction of the cylinder (2), and the guide blocks (4) and the guide grooves (5) correspond one-to-one.

6. The rapid biological sample detection device according to any one of claims 2 to 5, wherein the biological sample accommodating body (3) further comprises: A plurality of first seals (6), at least one of the first seals (6) is mounted on the outer wall of each of the protrusions (35); the first seals (6) form a sealed connection between the outer wall of the protrusion (35) and the inner wall of the reaction tank (22) that houses the protrusion (35).

7. The rapid biological sample detection device according to any one of claims 1 to 6, further comprising: Multiple second seals (7) are provided, with each exhaust channel (33) having a second seal (7) installed on its top, and the second seals (7) forming a sealed connection with the bottom surface (13) of the cover (1).

8. The rapid biological sample detection device according to any one of claims 1 to 7, further comprising: The third seal (8) is installed on the top of the biological sample container body (3) and is located outside all the exhaust channels (33); the third seal (8) forms a sealed connection with the bottom surface (13) of the cover (1).

9. The rapid biological sample detection device according to any one of claims 2 to 6, wherein the cylinder (2) comprises: The cylindrical portion (23) includes the mounting cavity (21); the main body portion (34) is mounted in the mounting cavity (21) of the cylindrical portion (23); as well as Multiple protrusions (24) are located at the bottom of the cylindrical part (23) and are fixedly connected to the cylindrical part (23); each of the protrusions (24) is spaced apart; each of the protrusions (24) protrudes in a direction away from the top of the cylindrical part (23); each of the protrusions (24) is provided with a reaction tank (22).

10. The rapid detection device for biological samples according to claim 9, wherein the cylinder (2) further comprises: A baffle plate (25) is fixed to the bottom of the side wall of the cylinder (2) and located on the outer periphery of the reaction tank (22) to prevent it from touching the outer wall of the reaction tank (22).

11. The rapid biological sample detection device according to any one of claims 1 to 10, wherein the cover (1) comprises: The cover body (11) is detachably connected to the cylinder body (2); as well as A column (12) is fixedly connected to the cover body (11), and one end of the column (12) is fixedly connected to the middle position of the cover body (11). The length of the column (12) is greater than the height of the cover body (11). When the cover (1) and the cylinder (2) are installed in place, the other end of the column (12) away from the cover body (11) abuts against the top opening of the drain pipe (32).

12. The rapid biological sample detection device according to any one of claims 1 to 11, wherein the drain pipe (32) is connected to the reaction tank (22) in a one-to-one correspondence; and / or, the exhaust channel (33) is connected to the reaction tank (22) in a one-to-one correspondence.

13. The rapid biological sample detection device according to any one of claims 1 to 12, wherein the cylinder (2) further comprises: Anti-slip part (26) is provided on the outer wall of the cylinder (2).

14. The rapid detection device for biological samples according to any one of claims 1 to 13, wherein each of the reaction pools (22) is pre-placed with different types of detection substances (9); and / or, the number of reaction pools (22) is 2 to 16.

15. The rapid detection device for biological samples according to any one of claims 1 to 14, wherein the volumes of each of the reaction cells (22) are equal.

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