Novel recombinant TET3 enzymes

WO2025224162A1PCT designated stage Publication Date: 2025-10-30QUGEN GMBH
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Patent Information

Application Number
PCT/EP2025/061045
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2025-01-22
Filing Date
2025-04-23
Publication Date
2025-10-30

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Abstract

The present invention refers to a recombinant Ten Eleven Translocation 3 (TET3) enzyme, a nucleic acid molecule encoding the TET3 enzyme, a vector comprising the nucleic acid molecule and a host cell transformed or transfected with the vector, the use of the recombinant TET3 enzyme for sequencing of a nucleic acid substrate, a method for sequencing a nucleic acid substrate and a reagent for sequencing a nucleic acid substrate.
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Citation Information

Patent Citations

  • Method for determining 5-methylcytosine, cytosine and 5-methyldeoxycytidine in plasma deoxyribonucleic acid

    CN111220760A

  • Recombinant TET3 enzymes

    EP4640827A1

  • Hyperactive AID / APOBEC and hmC Dominant TET Enzymes

    US20190010478A1

  • Engineered TET enzymes and use in epigenetics and next generation sequencing (NGS), such as TET-assisted pyridine borane sequencing (TAPS)

    WO2024224324A1