System for modifying water mineralization and for modifying certain physicochemical properties of water

Abstract

The invention relates to a device for modifying the ability of water to dissolve, dilute or extract other substances (solvent properties). This device makes it possible to precisely adjust the mineral concentration of the water used and to expose the water to trains of photons, the parameters of which can be computationally defined (total exposure time, duration of the trains, exposure frequency and wavelength). The device contains preset parameters that make it possible to obtain an optimal modification of the physicochemical properties of the mineralized water and to facilitate the process of dissolving certain solutes. The invention also relates to the use of the water obtained according to the invention in cosmetic compositions.

Description

Description Title of the invention: System for modifying the mineralization of water and modifying certain physicochemical properties of water

[0001] The invention relates to a device for modifying the ability of water to dissolve, dilute, or extract other substances (solvent properties). This device allows for precise adjustment of the mineral concentration of the water used and exposes the water to photon trains whose parameters can be defined by computer (total exposure time, train duration, exposure frequency, and wavelength). The device includes preset parameters that allow for optimal modification of the physicochemical properties of the mineralized water and facilitate the dissolution of certain solutes. The invention also relates to the use of the water obtained according to the invention in cosmetic compositions. Previous Art

[0002] In light of climate challenges and the ongoing need to conserve available resources, the constant need to improve industrial processes remains. The system, devices, and method described in this invention address these needs.

[0003] Water is an excellent polar solvent capable of dissolving many molecules. In the water molecule (H₂O), the electrons of the hydrogen atoms are strongly attracted to the oxygen atom, to the point of being closer to the oxygen nucleus than to the hydrogen nuclei. This is why water has a negative charge around the oxygen atom and a positive charge towards the hydrogen atoms, thus constituting an electrostatic dipole. Consequently, in the liquid state, water molecules have a natural tendency to position themselves relative to each other in such a way as to minimize the potential energy between them, forming agglomerates with a more or less crystalline structure, called "clusters." Typically, clusters can be partially or completely tetrahedral, but other configurations are possible. Furthermore, water in its liquid state always has a certain ratio of structured to unstructured parts.

[0004] The rate at which water molecules agglomerate into clusters influences the properties of water, including: - the surface tension of water which influences the ability of water to dissolve other molecules, and consequently the maximum rate of dissolution of a solute in water (saturated solution); - the ability of the solute to interact with other molecules.

[0005] The present invention relates to the field of water treatment by radiation, preferably by light radiation, so as to modify the rate of agglomeration of water molecules into clusters and / or the structure of the clusters of water molecules.

[0006] This invention is initially intended for preparations for cosmetic use, but other uses can be made of it, for example for dermatological products, for decoctions, infusions, food products, hydroalcoholic solutions, biological culture media. Description of the invention

[0007] According to a first aspect, the invention relates to a device for modifying the mineralization of water.

[0008] Preferably, this device for controlling mineralization includes a means of measuring the mineral concentration of the water.

[0009] Preferably, this device for controlling mineralization includes a means for adjusting the mineral concentrations of the water.

[0010] Preferably, this device for controlling mineralization includes preset parameters that can be adjusted by the user.

[0011] This device allows for precise adjustment of the mineral concentration of the water used.

[0012] In particular, this device allows control of the concentration of negatively charged ions in water, and more preferably, the concentration of negatively charged ions chosen from: Cl', PCL 2 ', NCL 2 ', F', HCCL', SCL 2 '.

[0013] According to a second aspect, the invention relates to a device for exposing water to a source of radiation, preferably a source of light.

[0014] Preferably, said radiation source is a light source.

[0015] Preferably, said device for exposing said water to a light source comprises: - A power supply (1).

[0016] Preferably, said device for exposing said water to a light source comprises: - An electronic controller comprising an interface (2).

[0017] Preferably, said device for exposing said water to a light source comprises: - A light source (3) having the capacity to emit at a wavelength between 200 and 1200 nm.

[0018] Preferably, said device for exposing said water to a light source comprises: - A container (4).

[0019] According to one embodiment, said device for exposing said water to a light source comprises: - An opaque container (4) comprising an opaque lid having at least one opening.

[0020] In another embodiment, the container comprises a closed reservoir into which filling is carried out via an inlet port with a tap and emptying through an outlet port with a valve. An overflow limits the level.

[0021] Preferably, said device for exposing said water to a light source comprises: - A power supply (1); - An electronic controller comprising an interface (2); - A light source (3) having the capacity to emit at a wavelength between 200 and 1200 nm; - An opaque container (4) comprising an opaque lid having at least one opening.

[0022] Preferably, the device includes an optical fiber.

[0023] Preferably, said light source (3) consists of at least one light-emitting diode lamp, or a laser, or an arc lamp, preferably xenon.

[0024] Even more preferably, said light source (3) consists of a xenon arc lamp.

[0025] Even more preferably, said light source (3) consists of light-emitting diodes

[0026] According to a third aspect, the invention relates to a system comprising the devices of the first and second aspects of the invention.

[0027] Thus, the invention relates to a system for modifying the mineralization of water, and for modifying the agglomeration rate of water molecules into clusters and / or the structure of water molecule clusters, comprising: - A device that allows the mineralization of water to be modified; - A device for exposing said water to a light source.

[0028] Preferably, the device for controlling mineralization includes a means of measuring the mineral concentration of the water.

[0029] Preferably, the device for controlling mineralization includes a means for adjusting the mineral concentrations in the water.

[0030] Preferably, the device for controlling mineralization includes preset and user-adjustable settings.

[0031] Preferably, said device for exposing said water to a light source comprises: - A power supply (1).

[0032] Preferably, said device for exposing said water to a light source comprises: - An electronic controller comprising an interface (2).

[0033] Preferably, said device for exposing said water to a light source comprises: - A light source (3) having the capacity to emit at a wavelength between 200 and 1200 nm.

[0034] Preferably, said device for exposing said water to a light source comprises: - A container (4).

[0035] According to one embodiment, said device for exposing said water to a light source comprises: - An opaque container (4) comprising an opaque lid having at least one opening.

[0036] In another embodiment, the container comprises a closed reservoir into which filling is carried out via an inlet port with a tap and emptying through an outlet port with a valve. An overflow limits the level.

[0037] Preferably, said device for exposing said water to a light source comprises: - A power supply (1); - An electronic controller comprising an interface (2); - A light source (3) having the capacity to emit at a wavelength between 200 and 1200 nm; - An opaque container (4) comprising an opaque lid having at least one opening.

[0038] Preferably, the device includes an optical fiber.

[0039] Preferably, said light source (3) consists of at least one light-emitting diode lamp, or a laser, or an arc lamp, preferably xenon.

[0040] Even more preferably, said light source (3) consists of a xenon arc lamp.

[0041] According to a fourth aspect, the invention relates to a method of modification of the mineralization of water.

[0042] Preferably, the objective of modifying the mineralization of water is to control the concentration of negatively charged ions.

[0043] According to one embodiment of the invention, said process for modifying the mineralization of water is carried out by mixing several waters of different mineralizations.

[0044] According to a fifth aspect, the invention relates to a method for modifying the rate of agglomeration of water molecules into clusters and / or the structure of water molecule clusters, comprising a step of exposing the water to a light source emitting at a wavelength between 200 and 1200 nm.

[0045] Preferably, this exposure stage lasts between 3 and 5 hours.

[0046] Preferably, said exposure step is carried out at an exposure frequency between 0.1 and 3 Hz, preferably between 0.5 and 1.5 Hz.

[0047] According to a sixth aspect, the invention relates to a method for modifying the mineralization of water and modifying the rate of agglomeration of water molecules into clusters and / or the structure of water molecule clusters, using a device according to the invention, comprising the steps of: i. Modifying the mineralization of the water; ii. Exposing the water to a light source emitting at a wavelength between 200 and 1200 nm, at an exposure frequency between 0.1 and 3 Hz, preferably between 0.5 and 1.5 Hz.

[0048] This method makes it possible to obtain water with a modified organization and / or structure of water molecules, optimized for the intended use.

[0049] Preferably, said exposure step ii. lasts between 1 minute and 24 hours, preferably between 5 minutes and 12 hours, even more preferably between 10 minutes and 5 hours.

[0050] Preferably, said exposure step ii is carried out on a quantity ranging from 10 mL to 500 L of water, preferably between 100 mL and 400 L, even more preferably between 100 mL and 200 L.

[0051] This method makes it possible to reduce the surface tension of water, in order to promote the design of aqueous solutions.

[0052] The method according to the invention makes it possible to reduce the quantities of ingredients used in a cosmetic composition by between 10% and 50%.

[0053] According to a seventh aspect, the invention relates to the use of water obtained by the devices, systems or methods according to the invention in cosmetic preparations.

[0054] Preferably, this use is carried out in a non-therapeutic cosmetic preparation allowing for hair renewal.

[0055] Preferably, said use is carried out in a non-therapeutic cosmetic preparation to preserve hair colour.

[0056] Preferably, this use is carried out in a non-therapeutic cosmetic preparation to revive hair colour.

[0057] Preferably, said use is carried out in a non-therapeutic cosmetic preparation to reduce skin irritations.

[0058] Preferably, this use is carried out in a non-therapeutic anti-aging cosmetic preparation.

[0059] Preferably, said use is carried out in a non-therapeutic cosmetic preparation to reduce skin imperfections.

[0060] According to an eighth aspect, the invention relates to the use of water obtained by the devices, systems or methods according to the invention in dermatological compositions.

[0061] According to a ninth aspect, the invention relates to the use of water obtained by the devices, systems or methods according to the invention in decoctions.

[0062] According to a tenth aspect, the invention relates to the use of water obtained by the devices, systems or methods according to the invention in infusions.

[0063] According to an eleventh aspect, the invention relates to the use of water obtained by the devices, systems or methods according to the invention in food products.

[0064] According to a twelfth aspect, the invention relates to the use of water obtained by the devices, systems or methods according to the invention in hydroalcoholic solutions.

[0065] According to a thirteenth aspect, the invention relates to the use of water obtained by the devices, systems or methods according to the invention in biological culture media.

[0066] According to a fourteenth aspect, the invention relates to a cosmetic composition comprising water as obtained by the Devices, Systems or Methods according to the invention.

[0067] According to one embodiment, said cosmetic composition promotes hair renewal.

[0068] According to one embodiment, said composition helps to preserve hair colour.

[0069] According to one embodiment, the composition makes it possible to revive hair colour.

[0070] According to one embodiment, said composition makes it possible to reduce skin irritations.

[0071] According to one embodiment, the said composition is an anti-aging composition.

[0072] According to one embodiment, said composition makes it possible to reduce skin imperfections.

[0073] According to a fifteenth aspect, the invention relates to a composition for use of water as obtained by the Devices, Systems or Methods according to the invention in a dermatological drug.

[0074] According to one embodiment, the composition is for use in the treatment of alopecia.

[0075] According to one embodiment, the composition is for use in the treatment of eczema.

[0076] According to one embodiment, the composition is for use in the treatment of acne

[0077] According to a sixteenth aspect, the invention relates to a cosmetic composition to promote hair renewal comprising water as obtained by the Devices, Systems or Methods according to the invention.

[0078] According to a seventeenth aspect, the invention relates to a cosmetic composition for preserving hair colour comprising water as obtained by the system or method according to Devices, Systems or Methods according to the invention.

[0079] According to an eighteenth aspect, the invention relates to the use of water as obtained by the system or method according to Devices, Systems or Methods according to the invention to modify the perfume notes of a cosmetic composition.

[0080] According to one embodiment for all aspects of the invention, the exposed water may also include mineral salts.

[0081] Preferably, the said mineral salts are chosen from: Calcium, Chlorine, Magnesium, Phosphorus, Potassium, Sodium, Sulfur.

[0082] Preferably, the cosmetic compositions addressed in the various aspects according to the invention may also comprise at least one other cosmetically acceptable compound, preferably chosen from among agents for reducing irritation, redness and / or itching, agents promoting healing, agents promoting hair renewal, agents for preserving or reviving hair color, agents for reducing skin imperfections, soothing agents, restructuring agents, regenerating agents, revitalizing agents, sunscreens, anti-wrinkle agents, moisturizing agents, anti-aging agents, surfactants, fatty substances, organic solvents, solubilizing agents, thickening and gelling agents, smoothing agents, agents enhancing the firmness, elasticity and / or barrier effect of the skin, antioxidants, opacifiers,Stabilizing agents, foaming agents, perfumes, ionic or non-ionic emulsifiers, fillers, sequestrants and chelators, perfumes, filters, essential oils, coloring agents, pigments, hydrophilic or lipophilic active ingredients, lipid vesicles encapsulating one or more active ingredients and / or preservatives.

[0083] The compositions described in the various aspects of the invention may also contain commonly used additives in the cosmetic and dermatological fields, such as hydrophilic or lipophilic gelling agents, hydrophilic or lipophilic active ingredients, preservatives, antioxidants, solvents, perfumes, fillers, filters, pigments, odor absorbers, and colorants. These additives, depending on their nature, may be incorporated into the oil phase, the aqueous phase, lipid vesicles, and / or nanoparticles.

[0084] Preferably, said compositions for dermatological use may also include other dermatological actives, preferably actives treating alopecia, eczema, or acne.

[0085] The use of this water allows in particular to modify the viscosity (increase or decrease) of the compositions and to have better absorption of water in the cellulose, and better dissolution of dyes, clay, polyphenols, drugs.

[0086] It also helps to reduce the mixing time of ingredients, and the reduction or intensification of odor.

[0087] The main benefit of this invention is the use of lower concentrations of solutes for at least equivalent performance, as these are much more effectively diluted in water. In particular, this allows for the use of fewer problematic compounds, such as irritants like essential oils, surfactants, or cellulose.

[0088] Using this water for watering also helps to promote plant metabolism (for example: improved photosynthesis or nutrient absorption). Figures

[0089] [Fig 1] is a diagram of the Device according to the invention, allowing water to be exposed to a light source.

[0090] [Fig 2] is a graph showing the effect of applying the Device on the viscosity of a mineral water in combination with a surfactant n=l independent experiments per group; *** : P=0.001; Mann-Whitney test.

[0091] [Fig 3] is a diagram of a second embodiment of the container of the invention, comprising a closed reservoir with an inlet port with a tap, an outlet port, a valve and an overflow.

[0092] [Fig 4] represents a photograph showing the results on skin expiants. The photograph on the left represents the control study (A), and the figure on the right represents the study using water as obtained by the Devices, Systems or Methods according to the invention (B).

[0093] [Fig 5] represents a graph of the expression kinetics of Laminin 5, showing the histological score as a function of time.

[0094] [Fig 6] represents a graph of the expression kinetics of Fibrillin 1, presenting the histological score as a function of time.

[0095] [Fig 7] represents a graph of Elastin expression kinetics, showing the histological score as a function of time.

[0096] [Fig 8] represents a graph of Collagen I expression kinetics, showing the histological score as a function of time.

[0097] [Fig 9] represents a graph of Collagen III expression kinetics, showing the histological score as a function of time.

[0098] [Fig 10] represents a histogram relating to the dosage of IL-1 alpha in the culture medium on day 2.

[0099] [Fig 11] represents a histogram of tissue expression of IL-1 alpha at day 6.

[0100] [Fig 12] represents a histogram of IL-8 released into the culture medium at day 6.

[0101] [Fig 13] represents a histogram of tissue expression of IL-8 at day 6.

[0102] Definition

[0103] For the purposes of this invention, "modifying the mineralization" means modifying the concentration of minerals in the water. In particular, it means modifying the concentration of negatively charged ions.

[0104] The term "radiation source" refers to a device that propagates energy from a radiating source in the form of electromagnetic waves. In the context of this invention, the radiation source is positioned near the water. Preferably, in this context, the radiation source is a light source.

[0105] By "exposing water to a light source" is meant that a working light source is positioned near the water, so that the photons that compose it act on the water.

[0106] For the purposes of this invention, "light source" means a device that projects photons, and therefore light, around itself.

[0107] For the purposes of this invention, "modifying the rate of agglomeration of water molecules into clusters" means influencing the formation of agglomerates (or clusters) of water molecules.

[0108] For the purposes of this invention, "modifying the structure of water molecule clusters" means modifying the average size of water clusters.

[0109] By "water cluster" is meant the constitution of groups of water molecules in semi-permanent structures, generally of partially or completely tetrahedral geometry.

[0110] For the purposes of this invention, "cosmetically acceptable" or "dermatologically acceptable" means something that is useful in the preparation of a cosmetic or dermatological composition, which is generally safe. non-toxic and neither biologically nor otherwise undesirable and which is acceptable for cosmetic use, including topical application to the skin.

[0111] For the purposes of this invention, "non-therapeutic" means a cosmetic application not intended to treat a patient. In fact, the cosmetic composition according to the invention does not act as a drug for the treatment of baldness, also known as alopecia, but rather improves the superficial visual appearance of the scalp.

[0112] "Hair renewal" refers to the non-therapeutic prevention and / or reduction of hair loss and baldness, thereby promoting natural hair regeneration. This hair treatment allows you to quickly and naturally regain visibly thicker hair.

[0113] "Alopecia treatment" is understood to mean the prevention and / or reduction of hair loss and baldness disorders, and thus acting for hair regeneration.

[0114] By "preserving hair color" is meant a composition capable of moisturizing and maintaining the shine of colored hair, and thus making the color applied to said hair last longer, by reducing the washing associated with shampooing.

[0115] "Reviving hair color" means getting closer to the original color applied to the hair after a period of time ranging from one to 12 weeks.

[0116] “Reducing skin irritation” means alleviating the visual signs of skin irritation that cause discomfort to the individual.

[0117] By "treatment of eczema" or "treatment of atopic dermatitis" is meant the reduction or prevention of this chronic inflammatory skin disease which manifests as inflammation of the skin.

[0118] The term "anti-aging" refers to the composition of the invention, which has a non-therapeutic cosmetic effect that improves the visible appearance of the skin, preferably facial skin, making it appear younger. The composition according to the invention thus hydrates, plumps, nourishes, revitalizes, smooths, regenerates, firms, reduces wrinkles, detoxifies the skin, brightens the complexion, diminishes signs of aging, and smooths and / or reduces the appearance of wrinkles and fine lines.

[0119] “Reducing skin imperfections” means a cosmetic composition that reduces the visibility of skin imperfections, such as pimples, enlarged pores, pigment spots, skin marks, or temporary or permanent residual scars.

[0120] "Acne treatment" refers to reducing or preventing this chronic inflammatory disease of the pilosebaceous follicle associated with abnormal multiplication of Propionibacterium acnes.

[0121] "Modifying the fragrance notes of a cosmetic composition" refers to generating different olfactory notes from a starting note, using devices, systems, and methods according to the invention, by altering the organization and / or structure of the molecules. This allows for a wider range of fragrance notes, which may be attenuated, intensified, or different. The devices, systems, and methods according to the invention also allow for reducing the concentration of fragrance in cosmetic compositions. Detailed description of the invention

[0122] According to a detailed embodiment, the invention relates to a system for modifying the mineralization of water, and for modifying the agglomeration rate of water molecules into clusters and / or the structure of water molecule clusters, comprising: - A device that allows the mineralization of water to be modified; - A device for exposing said water to a light source.

[0123] Before exposing the water to be treated to the light source, the user checks the water's mineral content, starting by monitoring its mineral concentration. Based on this concentration, the user then takes action to achieve a specific concentration of negatively charged ions, for example, by adding water with a high concentration of negatively charged ions.

[0124] Once the mineralization is adjusted, the user can transfer the water to be treated into the device allowing the water to be exposed to a light source.

[0125] Water is introduced into the container (4).

[0126] In a first embodiment, the container (4) includes a lid with at least one opening to allow the passage of light from the light source (3), either via an optical fiber or directly from the light source (3). The container (4) and its lid are opaque so as to protect the water from surrounding light radiation.

[0127] In a second embodiment, the container comprises a closed reservoir into which filling is carried out via an inlet port with a tap and emptying through an outlet port with a valve. An overflow limits the level.

[0128] The user can then select a program on the electronic controller interface (2), including the light wavelength parameters, exposure frequency and program duration.

[0129] The electronic controller and its interface (2) allow the application time and characteristics (duration, exposure frequency, and wavelength) of the projected photon trains to be defined.

[0130] The electronic controller and interface (2) also allow the selection of predefined programs, including parameters adapted to achieve optimal efficiency under predefined conditions. The interface also allows the user to save parameters.

[0131] The user can, for example, choose a wavelength between 200 and 1200 nm, a duration between 10 min and 5 hours, for quantities ranging from 200 ml to 2001, and an exposure frequency between 0.1 and 3 Hz, preferably between 0.5 and 1.5 Hz.

[0132] The controller is connected to the light source (3) which has the capacity to emit at a wavelength between 200 and 1200 nm. In one embodiment, this photo source is a xenon arc lamp.

[0133] The following examples demonstrate the effects of water as obtained by the Devices, Systems or Methods according to the invention on water, enabling: - Delay alterations in the survival of ex vivo skin explants; - Increase the expression of Laminin 5, which is a marker of epidermis / dermis adhesion; - Preserve fibrillin, which is a marker of surface elasticity; - Increase elastin, a marker of skin elasticity; - Increase collagen 1 and collagen 3, markers of dermal structure;

[0134] In particular, these examples also allow us to demonstrate: - An anti-hair loss application: 100% increase in the number of hairs preserved compared to the standard anti-hair loss product on the market. Study available - A hair colour preservation application (reducing washing out when shampooing): colour intensity superior to 4 standard shampoos on the hair colour preservation market; - Reviving hair colour (getting closer to the original colour which has faded after a period of time ranging from 1 week to 12 weeks): Positive visual assessment from a panel of experts for products containing water according to the invention; - A yellowing-reducing application for white hair (artificially bleached hair). Positive visual assessment from a panel of experts for the water-based products according to the invention; - A yellowing-reducing application for blonde hair (artificially bleached hair). Positive visual assessment from a panel of experts for the water-based products according to the invention; - An anti-irritation application: -40% to -70% of IL6 production in culture medium (as a preventative measure) and -60% to -80% of IL6 production in culture medium (in response to an inflammatory attack). - An application for modifying perfume notes: Positive olfactory appreciation from a panel of experts for products containing water according to the invention; - An anti-aging application: 30% increase in collagen for products containing water according to the invention; - An action of a clay scalp treatment on the epidermis by restoring aquaporins, (gene expression with DNA chip); - A detoxifying action (elimination of heavy metals) at 3 levels: epidermis, dermis and hypodermis. (Mask “INDIGO Rhythm”); - A silica potentiating action allowing better communication between skin cells, (revitalizing treatment water); - A reactivation of the sebaceous glands for dry hair (refractometer with very strict conditions) (Rhythm Rose Mask); - A reduction in hyperhidrosis (Green Rhythm Mask); - Preservation or recreation of disulfide bridges (White Rhythm Mask): Laser Raman Test; - An increase in the resistance of bleached hair (breakage test). Examples

[0135] Example 1: Study of the effect of applying a light source on the viscosity of mineral water.

[0136] Light exposure is applied using the device according to the invention to mineral water, in order to study the impact on the viscosity of the water, in comparison with an identical untreated mineral water.

[0137] A surfactant is added before measurement at the same concentration in mineral water undergoing the application of the light source, and in mineral water not undergoing it.

[0138] The experiment was repeated 7 times, and the data were studied using a Mann-Whitney test.

[0139] The results demonstrate a significantly decreased viscosity for water that has undergone light exposure.

[0140] Example 2: Impact study of the water obtained according to the invention on an existing ex-vivo model

[0141] The aim of the study is to determine whether the water obtained according to the invention in the culture medium improves the cellular and tissue morphology of the expiants in ex vivo survival.

[0142] The skin expiations come from a 45-year-old female donor, from the abdominal area.

[0143] A first culture medium B1 is placed under classic BEM conditions.

[0144] The second culture medium B2 is prepared with water obtained by the means as obtained by the Devices, Systems or Methods according to the invention: Water the obtained is prepared following the method according to the invention, with an exposure time of between 2 and 5 hours, with a xenon lamp, and an exposure to a wavelength of between 200 and 1200 nm, and an exposure frequency of between 0.1 and 3 Hz.

[0145] .

[0146] The general morphology of the skin expiations is then evaluated after Masson's trichrome staining.

[0147] The treatments are carried out on days 0, 1, 4, 6, 8, 11, and 13.

[0148] The cessation of expiations is carried out on days J0, J6, J8, J11, J13 and J15.

[0149] The results after 11 days are shown in Figure 4, the photograph on the left representing the control study (A), and the figure on the right the study using water as obtained by the Devices, Systems or Methods according to the invention (B).

[0150] Figure 4 demonstrates that the water as obtained by the Devices, Systems or Methods according to the invention makes it possible to delay the signs of an alteration in the survival of ex vivo expiants.

[0151] Additional immunostaining is performed on the expiry samples to test for different gene expressions: - Laminin 5 (Epidermal / Dermis Adhesion Marker): slight increase in Laminin 5 expression for water obtained according to the invention throughout survival. (Figure 5) - Fibrillin 1 (Surface elasticity marker): slight preservation of fibrillin over long periods for water obtained according to the invention (Figure 6) - Elastin (Elasticity Marker): slight increase in Elastin at short times for water obtained according to the invention (Figure 7) - Collagen I (Dermal structure marker): slight increase in collagen I throughout survival for water obtained according to the invention (Figure 8) - Collagen III (Dermal structure marker): slight increase in collagen III at short times for water obtained according to the invention (Figure 9)

[0152] Conclusion: The water obtained by the Devices, Systems or Methods according to the invention: - Helps prevent the appearance of alterations on ex vivo expiants - Tends to modulate the hydration of the stratum comeum (Filaggrin) - Tends to improve the anchoring of the epidermis to the dermis (Laminin 5) - Has a slight tendency to improve the elastic network (Fibrillin 1 & Elastin) - Has a slight tendency to preserve the collagen network (Collagens I and III)

[0153] Example 3: Testing the activity of formulations made with water obtained according to the invention and of formulations comprising water obtained according to the invention, on ex vivo skin expiants - evaluation of the activity of anti-inflammatory products on ex vivo human skin expiants.

[0154] The samples are tested on normal skin, and on skin exposed to 5% SDS for 4 hours, simulating an inflamed condition.

[0155] In both cases: - The expiators are studied for 6 days. - The treatments are carried out on JO, JI, J2, and J5. - The sampling of the environment is carried out on days J1, J2, J5, and J6.

[0156] The water obtained is prepared following the method according to the invention, with an exposure time of between 2 and 5 hours, with a xenon lamp, and an exposure to a wavelength of between 200 and 1200 nm, and an exposure frequency of between 0.1 and 3 Hz.

[0157] The products tested are as follows: [Table 1] Products tested

[0158] The conditions tested are as follows: [Table 2] Tested conditions

[0159] The application routine includes applying a mask followed by shampooing.

[0160] The mask was applied for 20 minutes at a rate of 2 µl per 1 cm² expansive area. 2 (~2mg / cm 2 )

[0161] The mask was rinsed with 20 ml of shampoo diluted to 5% in sterile distilled water, followed by 2 rinses with 20 ml of sterile distilled water.

[0162] The product's activity was evaluated by: - control of cell viability - CD immunostaining. - immunostaining and IL-1 assay - immunostaining and IL-8 assay [Table 3] Epidermal viability

[0163] The routines (mask and shampoo) induce primarily epidermal alterations. After exposure to SDS, the alterations are more significant.

[0164] [Table 4] Count of Langerhans cells

[0165] Whether in normal or inflamed conditions; routines (mask and shampoo) induce a migration of Langerhans cells.

[0166] There are no significant differences between the different treatment routines RI, R2, R3 and R4.

[0167] Alterations in general morphology may explain this depletion of Langerhans cells. [Table 5] IL-1 alpha assay in culture medium on day 2 more significant with RI and more moderate with other routines.

[0169] Under inflamed conditions, all routines induce IL-1 alpha in a similar manner. These elements are also presented in Figure 10. [Table 6] Tissue expression of IL-1 alpha at day 6

[0170] Immunostaining at day 6 shows moderate IL-1 alpha induction with RI, R3 and R4, which is mild with R2.

[0171] Under inflamed conditions, routines R2, R3, and R4 reduce IL-1 alpha, with R2 exhibiting a more pronounced effect. This indicates an ability to promote monocyte and neutrophil adhesion. These findings are also shown in Figure 11.

[0172] [Table 7] IL-8 assay in culture medium on day 6

[0173] These results demonstrate the ability to release IL-8 within the first 6 days, positively influencing the quality of the skin's immune defenses.

[0174] In inflamed conditions, only routine RI slightly reduces IL-8, with low statistical significance. These findings are also presented in Figure 12. [Table 8] Tissue expression of IL-8 at day 6

[0175] Immunostaining at day 6 shows moderate IL-8 induction with RI, more marked with R2, but more contained with R3 and R4.

[0176] In inflammatory conditions, all routines significantly reduce IL-8. These elements are also presented in Figure 13.

[0177] Conclusion :

[0178] On normal skin, routines show an induction of inflammation that is slightly lower with products containing water as obtained according to the invention.

[0179] Example 4: testing the activity of formulations made from water obtained according to the invention and of formulations comprising water obtained according to the invention, on ex vivo skin expiants - evaluation of the activity of anti-hair loss products on ex vivo scalp expiants.

[0180] The expiations are studied for 8 days - The treatments are carried out on days 0, 2, 5, and 7.

[0181] The water obtained is prepared following the method according to the invention, with an exposure time of between 1 and 10 hours, with a xenon lamp, and an exposure to a wavelength of between 200 and 1200 nm, and an exposure frequency of between 0.1 and 3 Hz.

[0182] The products tested are as follows:

[0183] The conditions tested are as follows: [Table 10] Conditions tested

[0184] The product's activity was evaluated by: - control of cell viability - immunostaining of collagen IV - immunostaining of laminin

[0185] The application routine includes applying a mask, then shampoo, then a lotion.

[0186] The mask was applied for 20 minutes at a rate of 2 pl per 1 cm2 expiant (~ 2mg / cm2)

[0187] The mask was rinsed with 20 ml of shampoo diluted to 5% in sterile distilled water, followed by 2 rinses with 20 ml of sterile distilled water.

[0188] The lotion was then applied at a rate of 2 pl per 1 cm2 expiant (~ 2mg / cm2).

[0189] Observations were made on different areas of the hair follicle and the interfollicular epidermis. The basal lamina corresponds to the junction between the keratinocytes of the epithelial sheaths and the adjacent papillary dermis.

[0190] The follicular papilla is a dermal structure located at the level of the bulb. [Table 11] Immunostaining of collagen IV [Table 12] Immunostaining of laminin

[0191] Both MSL and photoionized MSL routines induce an increase in laminin and collagen IV at the level of the basal lamina ensuring the adhesion of the epidermis to the dermis and the adhesion of the hair follicle to the dermis.

[0192] Both routines strengthen the anchoring of hair follicles, thus contributing to an anti-hair loss effect.

[0193] Compared to the water-free MSL application routine according to the invention, the water-containing MSL routine according to the invention induces greater expression of collagen IV in the interfollicular skin and in the upper part of the hair follicles. However, while laminin expression is higher than in the control, it is slightly lower than that obtained with the non-photoionized MSL routine in the hair follicles.

Claims

Demands

1. A system for modifying the mineralization of water, and for modifying the agglomeration rate of water molecules into clusters and / or the structure of water molecule clusters, comprising: - A device that allows the mineralization of water to be modified; - A device allowing said water to be exposed to a light source (3).

2. A system according to the preceding claim, wherein said device for exposing said water to a light source (3) comprises: - A power supply (1); - An electronic controller comprising an interface (2); - A light source (3) having the capacity to emit at a wavelength between 200 and 1200 nm; - A container (4).

3. System according to any one of the preceding claims, wherein said device for exposing said water to a light source (3) comprises an optical fiber.

4. System according to any one of the preceding claims, wherein said light source (3) consists of at least one light-emitting diode lamp, or a laser, or an arc lamp, preferably xenon.

5. Method of modifying the mineralization of water and modifying the rate of agglomeration of water molecules into clusters and / or the structure of water molecule clusters, using a device according to any one of the preceding claims, comprising the steps of: i. Modifying the mineralization of water; ii. Exposing water to a light source emitting at a wavelength between 200 and 1200 nm, at an exposure frequency between 0.1 and 3 Hz, preferably between 0.5 and 1.5 Hz.

6. Cosmetic composition comprising water as obtained by the system or method according to any one of the preceding claims.

7. Cosmetic composition to promote hair renewal comprising water as obtained by the system or method according to any one of claims 1 to 5.

8. A cosmetic hair colour preservation composition comprising water as obtained by the system or method according to any one of claims 1 to 5.

9. Non-therapeutic cosmetic use of a composition according to claim 6 to promote hair renewal.

10. Non-therapeutic cosmetic use of a composition according to claim 6 to preserve hair colour.

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