Nitrogen-containing 6-membered bicyclic derivatives with microbiocidal activity

Abstract

The current invention relates to compounds of the formula (I), (I) wherein the substituents are as defined in claim 1, to processes and methods for preparing compounds of formula (I), to agrochemical compositions comprising compounds of formula (I) as defined in claim 1, to preparation of these compositions and to the use of the compounds or compositions in agriculture or horticulture for combating, preventing or controlling infestation of plants, harvested food crops, seeds or non-living materials by phytopathogenic microorganisms, in particular fungi.

Description

[0001] NITROGEN-CONTAINING 6-MEMBERED BICYCLIC DERIVATIVESThe present invention relates to microbiocidal nitrogen-containing 6-membered bicyclic derivatives, e.g.as active ingredients, which have microbiocidal activity, in particular fungicidal activity, more particularlyactivity against oomycetes. The invention also relates to preparation of these nitrogen-containing 6-membered bicyclic derivatives, to intermediates useful in the preparation of these nitrogen-containing 6-membered bicyclic derivatives, to the preparation of these intermediates, to agrochemical compositions which comprise at least one of the nitrogen-containing 6-membered bicyclic derivatives, to preparation of these compositions and to the use of the nitrogen-containing 6-membered bicyclicderivatives or compositions in agriculture or horticulture for combating, controlling or preventinginfestation of plants, harvested food crops, seeds or non-living materials by phytopathogenic microorganisms, in particular fungi, more particularly oomycetes. It has now surprisingly been found that certain novel nitrogen-containing 6-membered bicyclicderivatives have favourable fungicidal properties, in particular against oomycetes.Therefore, in a first aspect, the present invention provides compounds of formula (I)(I) wherein Z is O or S, and A1is CH or N; A1aare independently CR1or N, with the proviso that no more than one A1ais N, and preferably two A1aare CR1;A1b are independently CR1 or N, with the proviso that no more than one A1b is N, preferably two A1b areCR1, and more preferably three A1bare CR1; R1are independently selected from hydrogen, hydroxy, halogen, CN, C1-6alkyl, C3-6cycloalkyl, C1- 6alkoxy-C1-6alkyl, C3-6cycloalkyl-C1-4alkyl, C1-6alkylsulfanyl. C1-6alkylsulfinyl, C1-6alkylsulfonyl, C1-6alkoxy,amino, and -NHC(O)C1-6alkyl; and preferably from hydrogen, halogen, CN, C1-6alkyl, C1-6alkoxy-C1-6alkyl, and C3-6cycloalkyl;A2are independently CR2or N, with the proviso that no more than three A2are N, preferably no more than two A2are N, preferably no more than one A2is N, and more preferably the four A2are CR2; R2are independently selected from hydrogen, hydroxy, halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy- C1-6alkyl, C1-6alkoxy-C1-6alkoxy, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1- 6alkylsulfanyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, C1-6alkoxycarbonyl, C1-6alkylaminocarbonyl, diC1- 6alkylaminocarbonyl, and C1-6alkylcarbonyl, wherein each of the C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1- 6alkyl, C1-6alkoxy-C1-6alkoxy, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1- 6alkylsulfanyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, C1-6alkoxycarbonyl, C1-6alkylaminocarbonyl, diC1- 6alkylaminocarbonyl, and C1-6alkylcarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; A3is CR3or N; R3is selected from hydrogen, hydroxy, halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1- 6alkoxy-C1-6alkoxy, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1-6alkylsulfanyl, C1- 6alkylsulfinyl, C1-6alkylsulfonyl, amino, C1-6alkylamino, diC1-6-alkylamino, and C3-6cycloalkylamino, wherein each of the C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1-6alkoxy-C1-6alkoxy, C2-6alkenyl, C2- 6alkynyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1-6alkylsulfanyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, amino, C1-6alkylamino, diC1-6-alkylamino, and C3-6cycloalkylamino groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; R4is selected from C1-6alkyl, C1-6alkoxy-C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, C2-6alkenyl, C2- 6alkynyl, C1-6alkoxy, C1-6alkylsulfanyl-C1-6alkyl, C1-6alkylsulfinyl-C1-6alkyl, C1-6alkylsulfonyl-C1-6alkyl, C1- 6alkoxycarbonyl-C1-6alkyl, C1-6alkylaminocarbonyl-C1-6alkyl, diC1-6alkylaminocarbonyl-C1-6alkyl, and CN, wherein each of the C1-6alkyl, C1-6alkoxy-C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, C2-6alkenyl, C2- 6alkynyl, C1-6alkoxy, C1-6alkylsulfanyl-C1-6alkyl, C1-6alkylsulfinyl-C1-6alkyl, C1-6alkylsulfonyl-C1-6alkyl, C1-6alkoxycarbonyl-C1-6alkyl, C1-6alkylaminocarbonyl-C1-6alkyl and diC1-6alkylaminocarbonyl-C1-6alkyl groups is optionally substituted with one to three substituents independently selected from halogen and CN; wherein A3and R4taken together optionally form a ring, more preferably a 5-8-membered heterocycle,and more preferably a 6-membered heterocycle; andR5is selected from C1-6alkyl, C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1-6alkoxyC1-6alkyl, C1- 6alkylamino, diC1-6alkylamino, C1-6alkoxyamino, and C1-6alkylC1-6alkoxyamino, wherein each of the C1-6alkyl, C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1-6alkoxyC1-6alkyl, C1-6alkylamino, diC1-6alkylamino, C1-6alkoxyamino, and C1-6alkylC1-6alkoxyamino groups is optionally substituted with one to three substituents independently selected from halogen and CN; or a salt or N-oxide thereof. In a second aspect the present invention provides an agrochemical composition comprising a compoundof formula (I), and more particularly an agrochemical composition comprising a fungicidally effectiveamount of a compound of formula (I). Said composition can further comprise at least one compound selected among an additional active ingredient, an appropriate formulation inert, a carrier, an adjuvant, and any mixtures thereof. Compounds of formula (I) may be used to control phytopathogenic microorganisms. Thus, in order to control a phytopathogen a compound of formula (I), or a composition comprising a compound of formula(I) according to the invention, may be applied directly to the phytopathogen, to the locus of aphytopathogen, in particular to a plant susceptible to attack by phytopathogens, or to a propagationmaterial of a plant.Thus, in a third aspect the present invention provides the use of a compound of formula (I), or a composition comprising a compound of formula (I), as described herein to combat, prevent or control a phytopathogen.In a fourth aspect the present invention provides a method of combating, preventing or controllingphytopathogens, comprising applying a compound of formula (I), or a composition comprising a compound of formula (I), as described herein to said phytopathogen, to the locus of said phytopathogen, in particular to a plant susceptible to attack by a phytopathogen, or to a propagation material of a plant.According to this fourth aspect of the invention, the method may exclude methods for the treatment ofthe human or animal body by surgery or therapy.Compounds of formula (I) are particularly effective in combating, preventing or controllingphytopathogenic fungi, in particular oomycetes. Thus, in a fifth aspect the present invention providesthe use of a compound of formula (I), or a composition comprising a compound of formula (I), asdescribed herein to control phytopathogenic fungi, in particular oomycetes.In a sixth aspect the present invention provides a method of combating, preventing or controllingphytopathogenic disease, such as phytopathogenic fungi, comprising applying a compound of formula (I), or a composition comprising a compound of formula (I), as described herein to said phytopathogenic fungi, or to the locus of said phytopathogenic fungi, in particular to a plant susceptible to attack byphytopathogenic fungi, in particular oomycetes, or to a propagation material of a plant. According to thissixth aspect of the invention, the method may exclude methods for the treatment of the human or animalbody by surgery or therapy. Where a group is indicated as being substituted, e.g. alkyl, this includes those groups that are part of other groups, e.g. the alkyl in alkylthio. Definitions:- The term "halogen" or “halo” refers to fluorine (fluoro or F), chlorine (chloro or Cl), bromine (bromo orBr) or iodine (iodo or I), preferably fluorine, chlorine or bromine.- The term “amino” refers to a -NH2 group.- The term "Alkyl" as used herein- in isolation or as part of a chemical group – represents straight-chainor branched hydrocarbons, preferably with 1 to 6 carbon atoms, for example methyl, ethyl, n-propyl,isopropyl, n-butyl, isobutyl, s-butyl, t-butyl, pentyl, 1- methylbutyl, 2-methylbutyl, 3-methylbutyl, 1,2-dimethylpropyl, 1,1 -dimethylpropyl, 2,2- dimethylpropyl, 1 -ethylpropyl, hexyl, 1 -methylpentyl, 2-methylpentyl, 3-methylpentyl, 4- methylpentyl, 1,2-dimethylpropyl, 1,3-dimethylbutyl, 1,4-dimethylbutyl,2,3-dimethylbutyl, 1,1- dimethylbutyl, 2,2-dimethylbutyl, 3,3-dimethylbutyl, 1,1,2-trimethylpropyl, 1,2,2-trimethylpropyl, 1- ethylbutyl and 2-ethylbutyl. Alkyl groups with 1 to 4 carbon atoms are preferred, forexample methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, s-butyl or t-butyl.- The term "Alkenyl" - in isolation or as part of a chemical group - represents straight-chain or branchedhydrocarbons, preferably with 2 to 6 carbon atoms and at least one double bond, for example vinyl, 2-propenyl, 2-butenyl, 3-butenyl, 1- methyl-2-propenyl, 2-methyl-2-propenyl, 2-pentenyl, 3-pentenyl, 4-pentenyl, 1-methyl-2-butenyl, 2- methyl-2-butenyl, 3-methyl-2-butenyl, 1-methyl-3-butenyl, 2-methyl-3-butenyl, 3-methyl-3-butenyl, 1,1 - dimethyl-2-propenyl, 1,2-dimethyl-2-propenyl, 1 -ethyl-2-propenyl, 2-hexenyl, 3-hexenyl, 4- hexenyl, 5-hexenyl, 1 -methyl-2-pentenyl, 2-methyl-2-pentenyl, 3-methyl-2-pentenyl, 4-methyl-2- pentenyl, 3-methyl-3-pentenyl, 4-methyl-3-pentenyl, 1 -methyl-4-pentenyl, 2-methyl-4-pentenyl, 3- methyl-4-pentenyl, 4-methyl-4-pentenyl, 1, 1 -dimethyl-2-butenyl, 1,1-dimethyl-3-butenyl, 1,2- dimethyl-2-butenyl, l,2-dimethyl-3-butenyl, 1,3-dimethyl-2-butenyl, 2,2-dimethyl-3-butenyl,2,3- dimethyl-2-butenyl, 2,3-dimethyl-3-butenyl, 1 -ethyl-2-butenyl, 1-ethyl-3-butenyl, 2-ethyl-2-butenyl,2-ethyl-3-butenyl, 1, 1,2-trimethyl-2-propenyl, 1 -ethyl- 1 -methyl-2-propenyl und 1-ethyl-2-methyl-2-propenyl. Alkenyl groups with 2 to 4 carbon atoms are preferred, for example 2-propenyl, 2-butenyl or 1-methyl-2-propenyl.- The term "Alkynyl" - in isolation or as part of a chemical group - represents straight-chain or branchedhydrocarbons, preferably with 2 to 6 carbon atoms and at least one triple bond, for example 2-propynyl,2-butynyl, 3-butynyl, 1-methyl-2- propynyl, 2-pentynyl, 3-pentynyl, 4-pentynyl, 1-methyl-3-butynyl, 2-methyl-3-butynyl, 1-methyl-2- butynyl, 1,1 -dimethyl-2-propynyl, 1 -ethyl-2-propynyl, 2-hexynyl, 3-hexynyl, 4-hexynyl, 5-hexynyl, 1- methyl-2-pentynyl, 1-methyl-3-pentynyl, 1 -methyl-4-pentynyl, 2-methyl-3-pentynyl, 2-methyl-4- pentynyl, 3 -methyl-4-pentynyl, 4-methyl-2-pentynyl, 1,1 -dimethyl-3 -butynyl, 1,2-dimethyl-3 –butynyl, 2,2- dimethyl-3-butynyl, 1-ethyl-3-butynyl, 2-ethyl-3-butynyl, 1-ethyl-1-methyl-2-propynyl and 2,5-hexadiynyl. Alkynyls with 2 to 4 carbon atoms are preferred, for exampleethynyl, 2- propynyl or 2-butynyl-2-propenyl.- The term "haloalkyl" refers to an alkyl radical as generally defined above substituted by one or moreof the same or different halogen atoms, for examples fluoromethyl, fluoroethyl, difluoromethyl, trifluoromethyl, or 2,2,2-trifluoroethyl.- The term cyanoalkyl” refers to an alkyl radical as generally defined above substituted by one or morecyano groups.- The term "cycloalkyl" - in isolation or as part of a chemical group - represents saturated or partiallyunsaturated mono-, bi- or tricyclic hydrocarbons, preferably with 3 to 10 carbon atoms, for examplecyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, bicyclo[2.2.1]heptyl, bicyclo[2.2.2]octyl or adamantyl. Cycloalkyls with 3, 4, 5, 6 or 7 carbon atoms are preferred, for example cyclopropyl or cyclobutyl.- The term “halocycloalkyl" refers to a cycloalkyl ring as defined above substituted by one or more of thesame or different halogen atoms.- The term cyanocycloalkyl” refers to a cycloalkyl radical as generally defined above substituted by oneor more cyano groups.- The term “alkoxy" refers to a radical of the formula -ORa wherein Ra is an alkyl radical as generallydefined above. Examples of alkoxy include, but are not limited to methoxy, ethoxy, propoxy, iso-propoxy,and tert-butoxy. The term “alkoxyalkyl” refers to an alkyl radical (as mentioned above) substituted withsaid alkoxy group. Examples are methoxymethyl, methoxyethyl, ethoxymethyl and propoxymethyl.- The term “alkylsulfanyl” refers to a radical of the formula -SRa wherein Ra is an alkyl radical as generallydefined above. - The term “alkylsulfinyl” refers to a radical of the formula -S(O)Ra wherein Ra is an alkyl radical as generally defined above.- The term “alkylsulfonyl” refers to a radical of the formula -S(O)2Ra wherein Ra is an alkyl radical asgenerally defined above.- The term “alkylcarbonyl” refers to a radical of the formula RaC(O)- wherein Ra is an alkyl radical asgenerally defined above.- the term “alkoxycarbonyl” refers to a radical of the formula RaOC(O)-, wherein Ra is an alkyl radical asgenerally defined above.- The term “alkylamino” refers to a radical of the formula RaNH- wherein Ra is an alkyl radical as generallydefined above.- The term “cycloalkylamino” refers to a radical of the formula RaNH- wherein Ra is a cycloalkyl radicalas generally defined above.- The term “alkoxyamino” refers to a radical of the formula RaNH-, wherein Ra is an alkoxy radical asgenerally defined above.- The term “alkylaminocarbonyl” refers to a radical of the formula RaNHC(O)- wherein Ra is an alkylradical as generally defined above.- Hydroxyl or hydroxy stands for a –OH group.The term ”combating”, “preventing” or “controlling”, and its inflections, within the context of the presentinvention, mean reducing any undesired effect, such as pathogenic and more particularlyphytopathogenic, especially fungi such as oomycetes, infestation or attack of, and pathogenic damage to a plant or to a plant derived product to such a level that an improvement is demonstrated. As used herein, the term "effective amount" refers to the amount of the compound, a salt, or N-oxide thereof, which, upon single or multiple applications provides the desired effect. An effective amount is readily determined by the skilled person in the art, by the use of known techniques and by observing results obtained under analogous circumstances. In determining the effective amount a number of factors are considered including, but not limited to: the type of plant or derived product tobe applied; the pathogen to be controlled & its lifecycle; the particular compound applied; the type ofapplication; and other relevant circumstances. Compounds of formula (I) which have at least one basic centre can form, for example, acid addition salts, for example with strong inorganic acids such as mineral acids, for example perchloric acid, sulfuric acid, nitric acid, nitrous acid, a phosphorus acid or a hydrohalic acid, with strong organic carboxylic acids, such as C1-4alkanecarboxylic acids which are unsubstituted or substituted, for example by halogen, for example acetic acid, such as saturated or unsaturated dicarboxylic acids, for example oxalicacid, malonic acid, succinic acid, maleic acid, fumaric acid or phthalic acid, such as hydroxycarboxylicacids, for example ascorbic acid, lactic acid, malic acid, tartaric acid or citric acid, or such as benzoicacid, or with organic sulfonic acids, such as C1-4alkane- or arylsulfonic acids which are unsubstituted orsubstituted, for example by halogen, for example methane- or p-toluenesulfonic acid. Compounds offormula (I) which have at least one acidic group can form, for example, salts with bases, for example mineral salts such as alkali metal or alkaline earth metal salts, for example sodium, potassium or magnesium salts, or salts with ammonia or an organic amine, such as morpholine, piperidine,pyrrolidine, a mono-, di- or tri-lower-alkylamine, for example ethyl-, diethyl-, triethyl- ordimethylpropylamine, or a mono-, di- or trihydroxy-lower-alkylamine, for example mono-, di- ortriethanolamine. In each case, the compounds of formula (I) according to the invention are in free form, in oxidized form as an N-oxide, in covalently hydrated form, or in salt form, e.g., an agronomically usable or agrochemically acceptable salt form. N-oxides are oxidized forms of tertiary amines or oxidized forms of nitrogen containing heteroaromatic compounds. They are described for instance in the book “Heterocyclic N-oxides” by A. Albini and S. Pietra, CRC Press, Boca Raton 1991. The compounds of formula (I) according to the invention also include hydrates, which may be formed during salt formation. The compounds of formula (I) according to the invention also include hydrates which may be formed during the salt formation. In a preferred embodiment of the compound of formula (I) according to the present invention, the twoA1acan be CR1. In another preferred embodiment of the compound of formula (I) according to the present invention, oneof the two A1a is CR1, and the other A1a is N, and more preferably the compound of formula (I) can beas follows: . In a particular embodiment, the compound of formula (I) according to the present invention can be asfollows:

[0002] , selected from hydrogen, halogen, CN, C1-6alkyl, C1-6alkoxy-C1-6alkyl, and C3-6cycloalkyl.In another particular embodiment, the compound of formula (I) according to the present invention canbe as follows: ,wherein the two A1a are CR1, selected from hydrogen, halogen, CN, C1-6alkyl, C1-6alkoxy-C1-6alkyl, and C3-6cycloalkyl.In another particular embodiment, the compound of formula (I) according to the present invention canbe as follows:C1- In a further embodiment, there is provided a compound of formula (I) according to the present invention, wherein R2 are independently selected from hydrogen, hydroxy, halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1-6alkoxy-C1-6alkoxy, C1-6alkoxycarbonyl, C1-6alkylaminocarbonyl, diC1-6alkylaminocarbonyl, and C1-6alkylcarbonyl, wherein each of the C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1-6alkoxy-C1-6alkoxy, C1-6alkoxycarbonyl, C1-6alkylaminocarbonyl, diC1-6alkylaminocarbonyl,and C1-6alkylcarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; preferably R2are independently selected from hydrogen, halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, and C1-6alkoxy-C1-6alkoxy, wherein each of the C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, and C1-6alkoxy-C1-6alkoxy groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and more preferably R2are independently selected from hydrogen, halogen, CN, C1-6alkyl, and C1-6alkoxy. In a further embodiment, there is provided a compound of formula (I) according to the present invention, wherein R3 is selected from hydrogen, hydroxy, halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl,C1-6alkoxy-C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1-6alkoxycarbonyl, amino, C1-6alkylamino, diC1-6-alkylamino, and C3-6cycloalkylamino, wherein each of the C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1- 6alkyl, C1-6alkoxy-C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1-6alkoxycarbonyl, amino, C1-6alkylamino, diC1-6-alkylamino and C3-6cycloalkylamino groups is optionally substituted with one to threesubstituents independently selected from halogen, hydroxy, and CN; and preferably R3is selected from hydrogen, hydroxy, halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, and C1-6alkoxycarbonyl, wherein each of the C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, and C1-6alkoxycarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN. In a preferred embodiment, R3 can be hydrogen.In a further embodiment, there is provided a compound of formula (I) according to the present invention, wherein four A2are CR2and A3is N. In a further embodiment, there is provided a compound of formula (I) according to the present invention, wherein and preferably the three A2 are CR2 and A3 is CR3. In a further embodiment, there is provided a compound of formula (I) according to the present invention, wherein and preferably the three A2 are CR2 and A3 is CR3. In a further embodiment, there is provided a compound of formula (I) according to the present invention, wherein four A2 are CR2 and A3 is CR3, and . In the particular embodiment , R2 are as defined in the present invention;preferably R2are independently halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1-6alkoxy-C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1-6alkoxycarbonyl, C1-6alkylaminocarbonyl, diC1-6alkylaminocarbonyl, and C1-6alkylcarbonyl, wherein each of the C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1-6alkoxy-C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1-6alkoxycarbonyl, C1-6alkylaminocarbonyl, diC1-6alkylaminocarbonyl, and C1-6alkylcarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; preferably R2 are independently selected from hydrogen, halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1-6alkoxycarbonyl, and C1-6alkoxy-C1-6alkoxy, wherein each of the C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1-6alkoxycarbonyl, and C1-6alkoxy-C1-6alkoxy groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and more preferably R2are independently selected from hydrogen, halogen, CN, C1-6alkyl, and C1-6alkoxy. In a further embodiment, there is provided a compound of formula (I) according to the present invention, wherein R4 is selected from C1-6alkyl, C1-6alkoxy-C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, C2-6alkenyl, C2-6alkynyl, and C1-6alkoxy, wherein each of the C1-6alkyl, C1-6alkoxy-C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, C2-6alkenyl, C2-6alkynyl, and C1-6alkoxy groups is optionally substituted with one to three substituents independently selected from halogen and CN; preferably and R4is selected from C1-6alkyl, C1-6alkoxy-C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, and C1-6alkoxy, wherein each of the C1-6alkyl, C1-6alkoxy-C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, and C1-6alkoxy groups is optionally substituted with one to three substituents independently selected from halogen and CN; and wherein A3and R4taken together optionally form a ring, preferably a 5-8-membered heterocycle, and more preferably a 6-membered heterocycle. In a further embodiment, there is provided a compound of formula (I) according to the present invention, wherein A3is CR3and wherein R3and R4taken together form a ring, preferably a 5-8-membered heterocycle, preferably a 6-membered heterocycle, and more preferably one of the rings W1, W2 or W3 as described in the compounds of the formula (I) below: The carbon and / or the nitrogen atoms forming said ring (W1, W2 or W3) can be substituted, especiallyby a R3’ group, wherein R3’ is selected from hydrogen, C1-6alkyl, and C3-6cycloalkyl, wherein each of theC1-6alkyl and C3-6cycloalkyl groups is optionally substituted with one to three substituents independently selected from halogen and CN. For example, the compounds of the formula (I-W3) can be as follows: W2) In a preferred embodiment, the compounds of the formula (I-W1), (I-W2) and (I-W3) can be as described below: W2) by a R3’ group, wherein R3’ is selected from hydrogen, C1-6alkyl, and C3-6cycloalkyl, wherein each of theC1-6alkyl and C3-6cycloalkyl groups is optionally substituted with one to three substituents independently selected from halogen and CN. For example, the compounds of the formula (I-W3) can be as follows: (I-W3) In a further embodiment, there is provided a compound of formula (I) according to the present invention,wherein R5 is selected from C1-6alkyl, C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, and C1-6alkoxyC1-6alkyl, wherein each of said groups is optionally substituted with one to three substituents independently selected from halogen and CN. In a particular embodiment, there is provided a compound of formula (I) according to the present invention, wherein Z is O; A1is CH or N; A1aare independently CR1or N, with the proviso that no more than one A1ais N, and preferably two A1aare CR1;A1b are independently CR1 or N, with the proviso that at least two A1b are CR1;R1 are independently selected from hydrogen, halogen, CN, C1-6alkyl, C1-6alkoxy-C1-6alkyl, and C3-6cycloalkyl;the four A2 are CR2; with R2 being independently selected from hydrogen, hydroxy, halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1-6alkoxy-C1-6alkoxy, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C3- 6cycloalkyl-C1-6alkyl, C1-6alkylsulfanyl, C1-6alkylsulfinyl, and C1-6alkylsulfonyl, wherein each of the C1- 6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1-6alkoxy-C1-6alkoxy, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C3- 6cycloalkyl-C1-6alkyl, C1-6alkylsulfanyl, C1-6alkylsulfinyl and C1-6alkylsulfonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN;preferably R2 being independently selected from hydrogen, halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1-6alkoxycarbonyl, and C1-6alkoxy-C1-6alkoxy, wherein each of the C1-6alkyl, C1-6alkoxy, C1-6alkoxycarbonyl, C1-6alkoxy-C1-6alkyl, and C1-6alkoxy-C1-6alkoxy groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; andmore preferably R2 being independently selected from hydrogen, halogen, CN, C1-6alkyl, and C1-6alkoxy,wherein each of the C1-6alkyl and C1-6alkoxy groups is optionally substituted with one to threesubstituents independently selected from halogen, hydroxy, and CN; A3is CR3with R3being selected from hydrogen, hydroxy, halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy- C1-6alkyl, C1-6alkoxy-C1-6alkoxy, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1- 6alkylsulfanyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, C1-6alkoxycarbonyl, amino, C1-6alkylamino, diC1-6- alkylamino, and C3-6cycloalkylamino, wherein each of the C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1-6alkoxy-C1-6alkoxy, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1-6alkylsulfanyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, C1-6alkoxycarbonyl, amino, C1-6alkylamino, diC1-6-alkylamino and C3-6cycloalkylamino groups is optionally substituted with one to three substituents independently selectedfrom halogen, hydroxy, and CN; and preferably R3 being hydrogen;R4is selected from C1-6alkyl, C1-6alkoxy-C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, and C1-6alkoxy, wherein each of the C1-6alkyl, C1-6alkoxy-C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, and C1-6alkoxy groups is optionally substituted with one to three substituents independently selected from halogen andCN; and wherein A3 and R4 taken together optionally form a ring, preferably a 5-8-memberedheterocycle, and more preferably a 6-membered heterocycle; andR5is selected from C1-6alkyl, C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1-6alkoxyC1-6 alkyl, C1- 6alkylamino, diC1-6alkylamino, and C1-6alkylC1-6alkoxyamino, wherein each of said groups is optionally substituted with one to three substituents independently selected from halogen and CN, and preferably R5is selected from C1-6alkyl, C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, and C1-6alkoxyC1-6alkyl, wherein each of said groups is optionally substituted with one to three substituents independently selected from halogen and CN.In a preferred , wherein R2 are as defined in the present invention;preferably R2are hydrogen, hydroxy, halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1-6alkoxy-C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1-6alkoxycarbonyl, C1-6alkylaminocarbonyl, diC1-6alkylaminocarbonyl, and C1-6alkylcarbonyl, wherein each of the C1-6alkyl,C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1-6alkoxy-C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1-6alkoxycarbonyl, C1-6alkylaminocarbonyl, diC1-6alkylaminocarbonyl, and C1-6alkylcarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, andCN; preferably R2 are independently selected from hydrogen, halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, and C1-6alkoxy-C1-6alkoxy, wherein each of the C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1- 6alkyl, and C1-6alkoxy-C1-6alkoxy groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; and more preferably R2are independently selected from hydrogen, halogen, CN, C1-6alkyl, and C1-6alkoxy. In a further embodiment, the compound according to the present invention is selected from: methyl N-[5-[7-[(4-fluoro-3-methoxy-phenyl)-methyl-carbamoyl]phthalazin-1-yl]-2-pyridyl]carbamate; methyl N-[5-[7-[(4-fluorophenyl)-methyl-carbamoyl]phthalazin-1-yl]-2-pyridyl]carbamate; methyl N-[5-[6-[(4-fluoro-3-methoxy-phenyl)-methyl-carbamoyl]cinnolin-4-yl]-2-pyridyl]carbamate; methyl N-[5-[6-[(4-fluorophenyl)-methyl-carbamoyl]cinnolin-4-yl]-2-pyridyl]carbamate; ethyl N-[5-[6-[(4-fluorophenyl)-methyl-carbamoyl]-4-isoquinolyl]-2-pyridyl]carbamate; methyl N-[5-[6-[(4-fluorophenyl)-methyl-carbamoyl]-4-isoquinolyl]-2-pyridyl]carbamate; methyl N-[5-[6-[(4-fluoro-3-methoxy-phenyl)-methyl-carbamoyl]-4-isoquinolyl]-2-pyridyl]carbamate; 4-(4-acetamidophenyl)-N-(4-chlorophenyl)-N-methyl-isoquinoline-6-carboxamide; methyl N-[4-[6-[(4-chlorophenyl)-methyl-carbamoyl]-4-isoquinolyl]phenyl]carbamate; and methyl N-[5-[6-[(4-fluoro-3-methoxy-phenyl)-methyl-carbamoyl]-8-methyl-cinnolin-4-yl]-2- pyridyl]carbamate. The method according to the present invention has advantageous properties for protecting plants against pathogenic, such as phytopathogenic, especially fungi such as oomycetes, attack or infestation, which result in a disease and damage to the plant; particularly in instance of plants, the present invention can control, limit or prevent pathogenic damage on plant, parts of plant, plant propagation material and / or plant grown.The compounds in Tables 1.1 to 1.600 below illustrate specific compounds of the invention.Table 1.1 provides compounds E1.1 to E1.836 of formula (Ia) (Ia) wherein R1is CH3, A1is CH, R2is H, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z. More particularly, table Z also includes compounds wherein R3and R4taken together form a ring. In this case, said ring is depicted in the R3 and R4 columns (table Z) merged together, along the amideatom linked to the bicycle core of the formula (Ia). For example, see the A3and R4columns of the compound E1.111. Table Z: Substituent definitions of A1a, A1b, A1a’, A3, R4, A2a and A2b:Compounds A1a A1b A1a’ A3 R4 A2a A2bE1.1 CH CH CH CH CH3 N CHE1.2 CH CH CH CH CH3 CH CHE1.3 CH CH CH CH CH3 CH NE1.4 CH CH CH CH CH3 CF CHE1.5 CH CH CH CH CH3 CF NE1.6 CH CH CH CH CH3 CCl CHE1.7 CH CH CH CH CH3 CCl NE1.8 CH CH CH CH CH3 CBr CHE1.9 CH CH CH CH CH3 CBr NE1.10 CH CH CH CH CH3 CCH3 CHE1.11 CH CH CH CH CH3 CCH3 NE1.12 CH CH CH CH CH3 CCH2CH3 CHE1.13 CH CH CH CH CH3 CCH2CH3 NE1.14 CH CH CH CH CH3 CCN CHE1.15 CH CH CH CH CH3 CCN NE1.16 CH CH CH CH CH2OCH3 N CHE1.17 CH CH CH CH CH2OCH3 CH CHE1.18 CH CH CH CH CH2OCH3 CH NE1.19 CH CH CH CH CH2OCH3 CF CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.20 CH CH CH CH CH2OCH3 CF NE1.21 CH CH CH CH CH2OCH3 CCl CHE1.22 CH CH CH CH CH2OCH3 CCl NE1.23 CH CH CH CH CH2OCH3 CBr CHE1.24 CH CH CH CH CH2OCH3 CBr NE1.25 CH CH CH CH CH2OCH3 CCH3 CHE1.26 CH CH CH CH CH2OCH3 CCH3 NE1.27 CH CH CH CH CH2OCH3 CCH2CH3 CHE1.28 CH CH CH CH CH2OCH3 CCH2CH3 NE1.29 CH CH CH CH CH2OCH3 CCN CHE1.30 CH CH CH CH CH2OCH3 CCN NE1.31 CH CH CH CH CH2CH2OCH3 N CHE1.32 CH CH CH CH CH2CH2OCH3 CH CHE1.33 CH CH CH CH CH2CH2OCH3 CH NE1.34 CH CH CH CH CH2CH2OCH3 CF CHE1.35 CH CH CH CH CH2CH2OCH3 CF NE1.36 CH CH CH CH CH2CH2OCH3 CCl CHE1.37 CH CH CH CH CH2CH2OCH3 CCl NE1.38 CH CH CH CH CH2CH2OCH3 CBr CHE1.39 CH CH CH CH CH2CH2OCH3 CBr NE1.40 CH CH CH CH CH2CH2OCH3 CCH3 CHE1.41 CH CH CH CH CH2CH2OCH3 CCH3 NE1.42 CH CH CH CH CH2CH2OCH3 CCH2CH3 CHE1.43 CH CH CH CH CH2CH2OCH3 CCH2CH3 NE1.44 CH CH CH CH CH2CH2OCH3 CCN CHE1.45 CH CH CH CH CH2CH2OCH3 CCN NE1.46 CH CH CH CH CH2CN N CHE1.47 CH CH CH CH CH2CN CH CHE1.48 CH CH CH CH CH2CN CH NE1.49 CH CH CH CH CH2CN CF CHE1.50 CH CH CH CH CH2CN CF NE1.51 CH CH CH CH CH2CN CCl CHE1.52 CH CH CH CH CH2CN CCl NE1.53 CH CH CH CH CH2CN CBr CHE1.54 CH CH CH CH CH2CN CBr NE1.55 CH CH CH CH CH2CN CCH3 CHE1.56 CH CH CH CH CH2CN CCH3 NE1.57 CH CH CH CH CH2CN CCH2CH3 CHE1.58 CH CH CH CH CH2CN CCH2CH3 NCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.59 CH CH CH CH CH2CN CCN CHE1.60 CH CH CH CH CH2CN CCN NE1.61 CH CH CH CH allyl N CHE1.62 CH CH CH CH allyl CH CHE1.63 CH CH CH CH allyl CH NE1.64 CH CH CH CH allyl CF CHE1.65 CH CH CH CH allyl CF NE1.66 CH CH CH CH allyl CCl CHE1.67 CH CH CH CH allyl CCl NE1.68 CH CH CH CH allyl CBr CHE1.69 CH CH CH CH allyl CBr NE1.70 CH CH CH CH allyl CCH3 CHE1.71 CH CH CH CH allyl CCH3 NE1.72 CH CH CH CH allyl CCH2CH3 CHE1.73 CH CH CH CH allyl CCH2CH3 NE1.74 CH CH CH CH allyl CCN CHE1.75 CH CH CH CH allyl CCN NE1.76 CH CH CH N CH3 CH CHE1.77 CH CH CH N CH3 CF CHE1.78 CH CH CH N CH3 CCl CHE1.79 CH CH CH N CH3 CBr CHE1.80 CH CH CH N CH3 CCH3 CHE1.81 CH CH CH N CH3 CCH2CH3 CHE1.82 CH CH CH N CH3 CCN CHE1.83 CH CH CH N CH2OCH3 CH CHE1.84 CH CH CH N CH2OCH3 CF CHE1.85 CH CH CH N CH2OCH3 CCl CHE1.86 CH CH CH N CH2OCH3 CBr CHE1.87 CH CH CH N CH2OCH3 CCH3 CHE1.88 CH CH CH N CH2OCH3 CCH2CH3 CHE1.89 CH CH CH N CH2OCH3 CCN CHE1.90 CH CH CH N CH2CH2OCH3 CH CHE1.91 CH CH CH N CH2CH2OCH3 CF CHE1.92 CH CH CH N CH2CH2OCH3 CCl CHE1.93 CH CH CH N CH2CH2OCH3 CBr CHE1.94 CH CH CH N CH2CH2OCH3 CCH3 CHE1.95 CH CH CH N CH2CH2OCH3 CCH2CH3 CHE1.96 CH CH CH N CH2CH2OCH3 CCN CHE1.97 CH CH CH N CH2CN CH CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.98 CH CH CH N CH2CN CF CHE1.99 CH CH CH N CH2CN CCl CHE1.100 CH CH CH N CH2CN CBr CHE1.101 CH CH CH N CH2CN CCH3 CHE1.102 CH CH CH N CH2CN CCH2CH3 CHE1.103 CH CH CH N CH2CN CCN CHE1.104 CH CH CH N allyl CH CHE1.105 CH CH CH N allyl CF CHE1.106 CH CH CH N allyl CCl CHE1.107 CH CH CH N allyl CBr CHE1.108 CH CH CH N allyl CCH3 CHE1.109 CH CH CH N allyl CCH2CH3 CHE1.110 CH CH CH N allyl CCN CHE1.111 CH CH CH N CHE1.112 CH CH CH CH CHE1.113 CH CH CH CH NE1.114 CH CH CH CF CHE1.115 CH CH CH CF NE1.116 CH CH CH CCl CHE1.117 CH CH CH CCl NE1.118 CH CH CH CBr CHE1.119 CH CH CH CBr NCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.120 CH CH CH CCH3 CHE1.121 CH CH CH CCH3 NE1.122 CH CH CH CCH2CH3 CHE1.123 CH CH CH CCH2CH3 NE1.124 CH CH CH CCN CHE1.125 CH CH CH CCN NE1.126 CH CH CH N CHE1.127 CH CH CH CH CHE1.128 CH CH CH CH NE1.129 CH CH CH CF CHE1.130 CH CH CH CF NE1.131 CH CH CH CCl CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.132 CH CH CH CCl NE1.133 CH CH CH CBr CHE1.134 CH CH CH CBr NE1.135 CH CH CH CCH3 CHE1.136 CH CH CH CCH3 NE1.137 CH CH CH CCH2CH3 CHE1.138 CH CH CH CCH2CH3 NE1.139 CH CH CH CCN CHE1.140 CH CH CH CCN NE1.141 CH CH N CH CH3 N CHE1.142 CH CH N CH CH3 CH CHE1.143 CH CH N CH CH3 CH NE1.144 CH CH N CH CH3 CF CHE1.145 CH CH N CH CH3 CF NE1.146 CH CH N CH CH3 CCl CHE1.147 CH CH N CH CH3 CCl NCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.148 CH CH N CH CH3 CBr CHE1.149 CH CH N CH CH3 CBr NE1.150 CH CH N CH CH3 CCH3 CHE1.151 CH CH N CH CH3 CCH3 NE1.152 CH CH N CH CH3 CCH2CH3 CHE1.153 CH CH N CH CH3 CCH2CH3 NE1.154 CH CH N CH CH3 CCN CHE1.155 CH CH N CH CH3 CCN NE1.156 CH CH N CH CH2OCH3 N CHE1.157 CH CH N CH CH2OCH3 CH CHE1.158 CH CH N CH CH2OCH3 CH NE1.159 CH CH N CH CH2OCH3 CF CHE1.160 CH CH N CH CH2OCH3 CF NE1.161 CH CH N CH CH2OCH3 CCl CHE1.162 CH CH N CH CH2OCH3 CCl NE1.163 CH CH N CH CH2OCH3 CBr CHE1.164 CH CH N CH CH2OCH3 CBr NE1.165 CH CH N CH CH2OCH3 CCH3 CHE1.166 CH CH N CH CH2OCH3 CCH3 NE1.167 CH CH N CH CH2OCH3 CCH2CH3 CHE1.168 CH CH N CH CH2OCH3 CCH2CH3 NE1.169 CH CH N CH CH2OCH3 CCN CHE1.170 CH CH N CH CH2OCH3 CCN NE1.171 CH CH N CH CH2CH2OCH3 N CHE1.172 CH CH N CH CH2CH2OCH3 CH CHE1.173 CH CH N CH CH2CH2OCH3 CH NE1.174 CH CH N CH CH2CH2OCH3 CF CHE1.175 CH CH N CH CH2CH2OCH3 CF NE1.176 CH CH N CH CH2CH2OCH3 CCl CHE1.177 CH CH N CH CH2CH2OCH3 CCl NE1.178 CH CH N CH CH2CH2OCH3 CBr CHE1.179 CH CH N CH CH2CH2OCH3 CBr NE1.180 CH CH N CH CH2CH2OCH3 CCH3 CHE1.181 CH CH N CH CH2CH2OCH3 CCH3 NE1.182 CH CH N CH CH2CH2OCH3 CCH2CH3 CHE1.183 CH CH N CH CH2CH2OCH3 CCH2CH3 NE1.184 CH CH N CH CH2CH2OCH3 CCN CHE1.185 CH CH N CH CH2CH2OCH3 CCN NE1.186 CH CH N CH CH2CN N CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.187 CH CH N CH CH2CN CH CHE1.188 CH CH N CH CH2CN CH NE1.189 CH CH N CH CH2CN CF CHE1.190 CH CH N CH CH2CN CF NE1.191 CH CH N CH CH2CN CCl CHE1.192 CH CH N CH CH2CN CCl NE1.193 CH CH N CH CH2CN CBr CHE1.194 CH CH N CH CH2CN CBr NE1.195 CH CH N CH CH2CN CCH3 CHE1.196 CH CH N CH CH2CN CCH3 NE1.197 CH CH N CH CH2CN CCH2CH3 CHE1.198 CH CH N CH CH2CN CCH2CH3 NE1.199 CH CH N CH CH2CN CCN CHE1.200 CH CH N CH CH2CN CCN NE1.201 CH CH N CH allyl N CHE1.202 CH CH N CH allyl CH CHE1.203 CH CH N CH allyl CH NE1.204 CH CH N CH allyl CF CHE1.205 CH CH N CH allyl CF NE1.206 CH CH N CH allyl CCl CHE1.207 CH CH N CH allyl CCl NE1.208 CH CH N CH allyl CBr CHE1.209 CH CH N CH allyl CBr NE1.210 CH CH N CH allyl CCH3 CHE1.211 CH CH N CH allyl CCH3 NE1.212 CH CH N CH allyl CCH2CH3 CHE1.213 CH CH N CH allyl CCH2CH3 NE1.214 CH CH N CH allyl CCN CHE1.215 CH CH N CH allyl CCN NE1.216 CH CH N N CH3 CH CHE1.217 CH CH N N CH3 CF CHE1.218 CH CH N N CH3 CCl CHE1.219 CH CH N N CH3 CBr CHE1.220 CH CH N N CH3 CCH3 CHE1.221 CH CH N N CH3 CCH2CH3 CHE1.222 CH CH N N CH3 CCN CHE1.223 CH CH N N CH2OCH3 CH CHE1.224 CH CH N N CH2OCH3 CF CHE1.225 CH CH N N CH2OCH3 CCl CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.226 CH CH N N CH2OCH3 CBr CHE1.227 CH CH N N CH2OCH3 CCH3 CHE1.228 CH CH N N CH2OCH3 CCH2CH3 CHE1.229 CH CH N N CH2OCH3 CCN CHE1.230 CH CH N N CH2CH2OCH3 CH CHE1.231 CH CH N N CH2CH2OCH3 CF CHE1.232 CH CH N N CH2CH2OCH3 CCl CHE1.233 CH CH N N CH2CH2OCH3 CBr CHE1.234 CH CH N N CH2CH2OCH3 CCH3 CHE1.235 CH CH N N CH2CH2OCH3 CCH2CH3 CHE1.236 CH CH N N CH2CH2OCH3 CCN CHE1.237 CH CH N N CH2CN CH CHE1.238 CH CH N N CH2CN CF CHE1.239 CH CH N N CH2CN CCl CHE1.240 CH CH N N CH2CN CBr CHE1.241 CH CH N N CH2CN CCH3 CHE1.242 CH CH N N CH2CN CCH2CH3 CHE1.243 CH CH N N CH2CN CCN CHE1.244 CH CH N N allyl CH CHE1.245 CH CH N N allyl CF CHE1.246 CH CH N N allyl CCl CHE1.247 CH CH N N allyl CBr CHE1.248 CH CH N N allyl CCH3 CHE1.249 CH CH N N allyl CCH2CH3 CHE1.250 CH CH N N allyl CCN CHE1.251 CH CH N N CHE1.252 CH CH N CH CHE1.253 CH CH N CH NE1.254 CH CH N CF CHE1.255 CH CH N CF NCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.256 CH CH N CCl CHE1.257 CH CH N CCl NE1.258 CH CH N CBr CHE1.259 CH CH N CBr NE1.260 CH CH N CCH3 CHE1.261 CH CH N CCH3 NE1.262 CH CH N CCH2CH3 CHE1.263 CH CH N CCH2CH3 NE1.264 CH CH N CCN CHE1.265 CH CH N CCN NE1.266 CH CH N N CHE1.267 CH CH N CH CHE1.268 CH CH N CH NCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.269 CH CH N CF CHE1.270 CH CH N CF NE1.271 CH CH N CCl CHE1.272 CH CH N CCl NE1.273 CH CH N CBr CHE1.274 CH CH N CBr NE1.275 CH CH N CCH3 CHE1.276 CH CH N CCH3 NE1.277 CH CH N CCH2CH3 CHE1.278 CH CH N CCH2CH3 NCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.279 CH CH N CCN CHE1.280 CH CH N CCN NE1.281 CH N CH CH CH3 N CHE1.282 CH N CH CH CH3 CH CHE1.283 CH N CH CH CH3 CH NE1.284 CH N CH CH CH3 CF CHE1.285 CH N CH CH CH3 CF NE1.286 CH N CH CH CH3 CCl CHE1.287 CH N CH CH CH3 CCl NE1.288 CH N CH CH CH3 CBr CHE1.289 CH N CH CH CH3 CBr NE1.290 CH N CH CH CH3 CCH3 CHE1.291 CH N CH CH CH3 CCH3 NE1.292 CH N CH CH CH3 CCH2CH3 CHE1.293 CH N CH CH CH3 CCH2CH3 NE1.294 CH N CH CH CH3 CCN CHE1.295 CH N CH CH CH3 CCN NE1.296 CH N CH CH CH2OCH3 N CHE1.297 CH N CH CH CH2OCH3 CH CHE1.298 CH N CH CH CH2OCH3 CH NE1.299 CH N CH CH CH2OCH3 CF CHE1.300 CH N CH CH CH2OCH3 CF NE1.301 CH N CH CH CH2OCH3 CCl CHE1.302 CH N CH CH CH2OCH3 CCl NE1.303 CH N CH CH CH2OCH3 CBr CHE1.304 CH N CH CH CH2OCH3 CBr NE1.305 CH N CH CH CH2OCH3 CCH3 CHE1.306 CH N CH CH CH2OCH3 CCH3 NE1.307 CH N CH CH CH2OCH3 CCH2CH3 CHE1.308 CH N CH CH CH2OCH3 CCH2CH3 NE1.309 CH N CH CH CH2OCH3 CCN CHE1.310 CH N CH CH CH2OCH3 CCN NE1.311 CH N CH CH CH2CH2OCH3 N CHE1.312 CH N CH CH CH2CH2OCH3 CH CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.313 CH N CH CH CH2CH2OCH3 CH NE1.314 CH N CH CH CH2CH2OCH3 CF CHE1.315 CH N CH CH CH2CH2OCH3 CF NE1.316 CH N CH CH CH2CH2OCH3 CCl CHE1.317 CH N CH CH CH2CH2OCH3 CCl NE1.318 CH N CH CH CH2CH2OCH3 CBr CHE1.319 CH N CH CH CH2CH2OCH3 CBr NE1.320 CH N CH CH CH2CH2OCH3 CCH3 CHE1.321 CH N CH CH CH2CH2OCH3 CCH3 NE1.322 CH N CH CH CH2CH2OCH3 CCH2CH3 CHE1.323 CH N CH CH CH2CH2OCH3 CCH2CH3 NE1.324 CH N CH CH CH2CH2OCH3 CCN CHE1.325 CH N CH CH CH2CH2OCH3 CCN NE1.326 CH N CH CH CH2CN N CHE1.327 CH N CH CH CH2CN CH CHE1.328 CH N CH CH CH2CN CH NE1.329 CH N CH CH CH2CN CF CHE1.330 CH N CH CH CH2CN CF NE1.331 CH N CH CH CH2CN CCl CHE1.332 CH N CH CH CH2CN CCl NE1.333 CH N CH CH CH2CN CBr CHE1.334 CH N CH CH CH2CN CBr NE1.335 CH N CH CH CH2CN CCH3 CHE1.336 CH N CH CH CH2CN CCH3 NE1.337 CH N CH CH CH2CN CCH2CH3 CHE1.338 CH N CH CH CH2CN CCH2CH3 NE1.339 CH N CH CH CH2CN CCN CHE1.340 CH N CH CH CH2CN CCN NE1.341 CH N CH CH allyl N CHE1.342 CH N CH CH allyl CH CHE1.343 CH N CH CH allyl CH NE1.344 CH N CH CH allyl CF CHE1.345 CH N CH CH allyl CF NE1.346 CH N CH CH allyl CCl CHE1.347 CH N CH CH allyl CCl NE1.348 CH N CH CH allyl CBr CHE1.349 CH N CH CH allyl CBr NE1.350 CH N CH CH allyl CCH3 CHE1.351 CH N CH CH allyl CCH3 NCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.352 CH N CH CH allyl CCH2CH3 CHE1.353 CH N CH CH allyl CCH2CH3 NE1.354 CH N CH CH allyl CCN CHE1.355 CH N CH CH allyl CCN NE1.356 CH N CH N CH3 CH CHE1.357 CH N CH N CH3 CF CHE1.358 CH N CH N CH3 CCl CHE1.359 CH N CH N CH3 CBr CHE1.360 CH N CH N CH3 CCH3 CHE1.361 CH N CH N CH3 CCH2CH3 CHE1.362 CH N CH N CH3 CCN CHE1.363 CH N CH N CH2OCH3 CH CHE1.364 CH N CH N CH2OCH3 CF CHE1.365 CH N CH N CH2OCH3 CCl CHE1.366 CH N CH N CH2OCH3 CBr CHE1.367 CH N CH N CH2OCH3 CCH3 CHE1.368 CH N CH N CH2OCH3 CCH2CH3 CHE1.369 CH N CH N CH2OCH3 CCN CHE1.370 CH N CH N CH2CH2OCH3 CH CHE1.371 CH N CH N CH2CH2OCH3 CF CHE1.372 CH N CH N CH2CH2OCH3 CCl CHE1.373 CH N CH N CH2CH2OCH3 CBr CHE1.374 CH N CH N CH2CH2OCH3 CCH3 CHE1.375 CH N CH N CH2CH2OCH3 CCH2CH3 CHE1.376 CH N CH N CH2CH2OCH3 CCN CHE1.377 CH N CH N CH2CN CH CHE1.378 CH N CH N CH2CN CF CHE1.379 CH N CH N CH2CN CCl CHE1.380 CH N CH N CH2CN CBr CHE1.381 CH N CH N CH2CN CCH3 CHE1.382 CH N CH N CH2CN CCH2CH3 CHE1.383 CH N CH N CH2CN CCN CHE1.384 CH N CH N allyl CH CHE1.385 CH N CH N allyl CF CHE1.386 CH N CH N allyl CCl CHE1.387 CH N CH N allyl CBr CHE1.388 CH N CH N allyl CCH3 CHE1.389 CH N CH N allyl CCH2CH3 CHE1.390 CH N CH N allyl CCN CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.391 CH N CH N CHE1.392 CH N CH CH CHE1.393 CH N CH CH NE1.394 CH N CH CF CHE1.395 CH N CH CF NE1.396 CH N CH CCl CHE1.397 CH N CH CCl NE1.398 CH N CH CBr CHE1.399 CH N CH CBr NE1.400 CH N CH CCH3 CHE1.401 CH N CH CCH3 NE1.402 CH N CH CCH2CH3 CHE1.403 CH N CH CCH2CH3 NE1.404 CH N CH CCN CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.405 CH N CH CCN NE1.406 CH N CH N CHE1.407 CH N CH CH CHE1.408 CH N CH CH NE1.409 CH N CH CF CHE1.410 CH N CH CF NE1.411 CH N CH CCl CHE1.412 CH N CH CCl NE1.413 CH N CH CBr CHE1.414 CH N CH CBr NE1.415 CH N CH CCH3 CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.416 CH N CH CCH3 NE1.417 CH N CH CCH2CH3 CHE1.418 CH N CH CCH2CH3 NE1.419 CH N CH CCN CHE1.420 CH N CH CCN NE1.421 CH N N CH CH3 N CHE1.422 CH N N CH CH3 CH CHE1.423 CH N N CH CH3 CH NE1.424 CH N N CH CH3 CF CHE1.425 CH N N CH CH3 CF NE1.426 CH N N CH CH3 CCl CHE1.427 CH N N CH CH3 CCl NE1.428 CH N N CH CH3 CBr CHE1.429 CH N N CH CH3 CBr NE1.430 CH N N CH CH3 CCH3 CHE1.431 CH N N CH CH3 CCH3 NE1.432 CH N N CH CH3 CCH2CH3 CHE1.433 CH N N CH CH3 CCH2CH3 NE1.434 CH N N CH CH3 CCN CHE1.435 CH N N CH CH3 CCN NE1.436 CH N N CH CH2OCH3 N CHE1.437 CH N N CH CH2OCH3 CH CHE1.438 CH N N CH CH2OCH3 CH NE1.439 CH N N CH CH2OCH3 CF CHE1.440 CH N N CH CH2OCH3 CF NE1.441 CH N N CH CH2OCH3 CCl CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.442 CH N N CH CH2OCH3 CCl NE1.443 CH N N CH CH2OCH3 CBr CHE1.444 CH N N CH CH2OCH3 CBr NE1.445 CH N N CH CH2OCH3 CCH3 CHE1.446 CH N N CH CH2OCH3 CCH3 NE1.447 CH N N CH CH2OCH3 CCH2CH3 CHE1.448 CH N N CH CH2OCH3 CCH2CH3 NE1.449 CH N N CH CH2OCH3 CCN CHE1.450 CH N N CH CH2OCH3 CCN NE1.451 CH N N CH CH2CH2OCH3 N CHE1.452 CH N N CH CH2CH2OCH3 CH CHE1.453 CH N N CH CH2CH2OCH3 CH NE1.454 CH N N CH CH2CH2OCH3 CF CHE1.455 CH N N CH CH2CH2OCH3 CF NE1.456 CH N N CH CH2CH2OCH3 CCl CHE1.457 CH N N CH CH2CH2OCH3 CCl NE1.458 CH N N CH CH2CH2OCH3 CBr CHE1.459 CH N N CH CH2CH2OCH3 CBr NE1.460 CH N N CH CH2CH2OCH3 CCH3 CHE1.461 CH N N CH CH2CH2OCH3 CCH3 NE1.462 CH N N CH CH2CH2OCH3 CCH2CH3 CHE1.463 CH N N CH CH2CH2OCH3 CCH2CH3 NE1.464 CH N N CH CH2CH2OCH3 CCN CHE1.465 CH N N CH CH2CH2OCH3 CCN NE1.466 CH N N CH CH2CN N CHE1.467 CH N N CH CH2CN CH CHE1.468 CH N N CH CH2CN CH NE1.469 CH N N CH CH2CN CF CHE1.470 CH N N CH CH2CN CF NE1.471 CH N N CH CH2CN CCl CHE1.472 CH N N CH CH2CN CCl NE1.473 CH N N CH CH2CN CBr CHE1.474 CH N N CH CH2CN CBr NE1.475 CH N N CH CH2CN CCH3 CHE1.476 CH N N CH CH2CN CCH3 NE1.477 CH N N CH CH2CN CCH2CH3 CHE1.478 CH N N CH CH2CN CCH2CH3 NE1.479 CH N N CH CH2CN CCN CHE1.480 CH N N CH CH2CN CCN NCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.481 CH N N CH allyl N CHE1.482 CH N N CH allyl CH CHE1.483 CH N N CH allyl CH NE1.484 CH N N CH allyl CF CHE1.485 CH N N CH allyl CF NE1.486 CH N N CH allyl CCl CHE1.487 CH N N CH allyl CCl NE1.488 CH N N CH allyl CBr CHE1.489 CH N N CH allyl CBr NE1.490 CH N N CH allyl CCH3 CHE1.491 CH N N CH allyl CCH3 NE1.492 CH N N CH allyl CCH2CH3 CHE1.493 CH N N CH allyl CCH2CH3 NE1.494 CH N N CH allyl CCN CHE1.495 CH N N CH allyl CCN NE1.496 CH N N N CH3 CH CHE1.497 CH N N N CH3 CF CHE1.498 CH N N N CH3 CCl CHE1.499 CH N N N CH3 CBr CHE1.500 CH N N N CH3 CCH3 CHE1.501 CH N N N CH3 CCH2CH3 CHE1.502 CH N N N CH3 CCN CHE1.503 CH N N N CH2OCH3 CH CHE1.504 CH N N N CH2OCH3 CF CHE1.505 CH N N N CH2OCH3 CCl CHE1.506 CH N N N CH2OCH3 CBr CHE1.507 CH N N N CH2OCH3 CCH3 CHE1.508 CH N N N CH2OCH3 CCH2CH3 CHE1.509 CH N N N CH2OCH3 CCN CHE1.510 CH N N N CH2CH2OCH3 CH CHE1.511 CH N N N CH2CH2OCH3 CF CHE1.512 CH N N N CH2CH2OCH3 CCl CHE1.513 CH N N N CH2CH2OCH3 CBr CHE1.514 CH N N N CH2CH2OCH3 CCH3 CHE1.515 CH N N N CH2CH2OCH3 CCH2CH3 CHE1.516 CH N N N CH2CH2OCH3 CCN CHE1.517 CH N N N CH2CN CH CHE1.518 CH N N N CH2CN CF CHE1.519 CH N N N CH2CN CCl CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.520 CH N N N CH2CN CBr CHE1.521 CH N N N CH2CN CCH3 CHE1.522 CH N N N CH2CN CCH2CH3 CHE1.523 CH N N N CH2CN CCN CHE1.524 CH N N N allyl CH CHE1.525 CH N N N allyl CF CHE1.526 CH N N N allyl CCl CHE1.527 CH N N N allyl CBr CHE1.528 CH N N N allyl CCH3 CHE1.529 CH N N N allyl CCH2CH3 CHE1.530 CH N N N allyl CCN CHE1.531 CH N N N CHE1.532 CH N N CH CHE1.533 CH N N CF CHE1.534 CH N N CCl CHE1.535 CH N N CBr CHE1.536 CH N N CCH3 CHE1.537 CH N N CCH3 NE1.538 CH N N CCH2CH3 CHE1.539 CH N N CCH2CH3 NE1.540 CH N N CCN CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.541 CH N N CCN NE1.542 CH N N N CHE1.543 CH N N CH CHE1.544 CH N N CH NE1.545 CH N N CF CHE1.546 CH N N CF NE1.547 CH N N CCl CHE1.548 CH N N CCl NE1.549 CH N N CBr CHE1.550 CH N N CBr NE1.551 CH N N CCH3 CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.552 CH N N CCH3 NE1.553 CH N N CCH2CH3 CHE1.554 CH N N CCH2CH3 NE1.555 CH N N CCN CHE1.556 CH N N CCN NE1.557 N CH CH CH CH3 N CHE1.558 N CH CH CH CH3 CH CHE1.559 N CH CH CH CH3 CH NE1.560 N CH CH CH CH3 CF CHE1.561 N CH CH CH CH3 CF NE1.562 N CH CH CH CH3 CCl CHE1.563 N CH CH CH CH3 CCl NE1.564 N CH CH CH CH3 CBr CHE1.565 N CH CH CH CH3 CBr NE1.566 N CH CH CH CH3 CCH3 CHE1.567 N CH CH CH CH3 CCH3 NE1.568 N CH CH CH CH3 CCH2CH3 CHE1.569 N CH CH CH CH3 CCH2CH3 NE1.570 N CH CH CH CH3 CCN CHE1.571 N CH CH CH CH3 CCN NE1.572 N CH CH CH CH2OCH3 N CHE1.573 N CH CH CH CH2OCH3 CH CHE1.574 N CH CH CH CH2OCH3 CH NE1.575 N CH CH CH CH2OCH3 CF CHE1.576 N CH CH CH CH2OCH3 CF NE1.577 N CH CH CH CH2OCH3 CCl CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.578 N CH CH CH CH2OCH3 CCl NE1.579 N CH CH CH CH2OCH3 CBr CHE1.580 N CH CH CH CH2OCH3 CBr NE1.581 N CH CH CH CH2OCH3 CCH3 CHE1.582 N CH CH CH CH2OCH3 CCH3 NE1.583 N CH CH CH CH2OCH3 CCH2CH3 CHE1.584 N CH CH CH CH2OCH3 CCH2CH3 NE1.585 N CH CH CH CH2OCH3 CCN CHE1.586 N CH CH CH CH2OCH3 CCN NE1.587 N CH CH CH CH2CH2OCH3 N CHE1.588 N CH CH CH CH2CH2OCH3 CH CHE1.589 N CH CH CH CH2CH2OCH3 CH NE1.590 N CH CH CH CH2CH2OCH3 CF CHE1.591 N CH CH CH CH2CH2OCH3 CF NE1.592 N CH CH CH CH2CH2OCH3 CCl CHE1.593 N CH CH CH CH2CH2OCH3 CCl NE1.594 N CH CH CH CH2CH2OCH3 CBr CHE1.595 N CH CH CH CH2CH2OCH3 CBr NE1.596 N CH CH CH CH2CH2OCH3 CCH3 CHE1.597 N CH CH CH CH2CH2OCH3 CCH3 NE1.598 N CH CH CH CH2CH2OCH3 CCH2CH3 CHE1.599 N CH CH CH CH2CH2OCH3 CCH2CH3 NE1.600 N CH CH CH CH2CH2OCH3 CCN CHE1.601 N CH CH CH CH2CH2OCH3 CCN NE1.602 N CH CH CH CH2CN N CHE1.603 N CH CH CH CH2CN CH CHE1.604 N CH CH CH CH2CN CH NE1.605 N CH CH CH CH2CN CF CHE1.606 N CH CH CH CH2CN CF NE1.607 N CH CH CH CH2CN CCl CHE1.608 N CH CH CH CH2CN CCl NE1.609 N CH CH CH CH2CN CBr CHE1.610 N CH CH CH CH2CN CBr NE1.611 N CH CH CH CH2CN CCH3 CHE1.612 N CH CH CH CH2CN CCH3 NE1.613 N CH CH CH CH2CN CCH2CH3 CHE1.614 N CH CH CH CH2CN CCH2CH3 NE1.615 N CH CH CH CH2CN CCN CHE1.616 N CH CH CH CH2CN CCN NCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.617 N CH CH CH allyl N CHE1.618 N CH CH CH allyl CH CHE1.619 N CH CH CH allyl CH NE1.620 N CH CH CH allyl CF CHE1.621 N CH CH CH allyl CF NE1.622 N CH CH CH allyl CCl CHE1.623 N CH CH CH allyl CCl NE1.624 N CH CH CH allyl CBr CHE1.625 N CH CH CH allyl CBr NE1.626 N CH CH CH allyl CCH3 CHE1.627 N CH CH CH allyl CCH3 NE1.628 N CH CH CH allyl CCH2CH3 CHE1.629 N CH CH CH allyl CCH2CH3 NE1.630 N CH CH CH allyl CCN CHE1.631 N CH CH CH allyl CCN NE1.632 N CH CH N CH3 CH CHE1.633 N CH CH N CH3 CF CHE1.634 N CH CH N CH3 CCl CHE1.635 N CH CH N CH3 CBr CHE1.636 N CH CH N CH3 CCH3 CHE1.637 N CH CH N CH3 CCH2CH3 CHE1.638 N CH CH N CH3 CCN CHE1.639 N CH CH N CH2OCH3 CH CHE1.640 N CH CH N CH2OCH3 CF CHE1.641 N CH CH N CH2OCH3 CCl CHE1.642 N CH CH N CH2OCH3 CBr CHE1.643 N CH CH N CH2OCH3 CCH3 CHE1.644 N CH CH N CH2OCH3 CCH2CH3 CHE1.645 N CH CH N CH2OCH3 CCN CHE1.646 N CH CH N CH2CH2OCH3 CH CHE1.647 N CH CH N CH2CH2OCH3 CF CHE1.648 N CH CH N CH2CH2OCH3 CCl CHE1.649 N CH CH N CH2CH2OCH3 CBr CHE1.650 N CH CH N CH2CH2OCH3 CCH3 CHE1.651 N CH CH N CH2CH2OCH3 CCH2CH3 CHE1.652 N CH CH N CH2CH2OCH3 CCN CHE1.653 N CH CH N CH2CN CH CHE1.654 N CH CH N CH2CN CF CHE1.655 N CH CH N CH2CN CCl CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.656 N CH CH N CH2CN CBr CHE1.657 N CH CH N CH2CN CCH3 CHE1.658 N CH CH N CH2CN CCH2CH3 CHE1.659 N CH CH N CH2CN CCN CHE1.660 N CH CH N allyl CH CHE1.661 N CH CH N allyl CF CHE1.662 N CH CH N allyl CCl CHE1.663 N CH CH N allyl CBr CHE1.664 N CH CH N allyl CCH3 CHE1.665 N CH CH N allyl CCH2CH3 CHE1.666 N CH CH N allyl CCN CHE1.667 N CH CH N CHE1.668 N CH CH CH CHE1.669 N CH CH CH NE1.670 N CH CH CF CHE1.671 N CH CH CF NE1.672 N CH CH CCl CHE1.673 N CH CH CCl NE1.674 N CH CH CBr CHE1.675 N CH CH CBr NE1.676 N CH CH CCH3 CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.677 N CH CH CCH3 NE1.678 N CH CH CCH2CH3 CHE1.679 N CH CH CCH2CH3 NE1.680 N CH CH CCN CHE1.681 N CH CH CCN NE1.682 N CH CH N CHE1.683 N CH CH CH CHE1.684 N CH CH CH NE1.685 N CH CH CF CHE1.686 N CH CH CF NE1.687 N CH CH CCl CHE1.688 N CH CH CCl NCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.689 N CH CH CBr CHE1.690 N CH CH CBr NE1.691 N CH CH CCH3 CHE1.692 N CH CH CCH3 NE1.693 N CH CH CCH2CH3 CHE1.694 N CH CH CCH2CH3 NE1.695 N CH CH CCN CHE1.696 N CH CH CCN NE1.697 N N CH CH CH3 N CHE1.698 N N CH CH CH3 CH CHE1.699 N N CH CH CH3 CH NE1.700 N N CH CH CH3 CF CHE1.701 N N CH CH CH3 CF NE1.702 N N CH CH CH3 CCl CHE1.703 N N CH CH CH3 CCl NE1.704 N N CH CH CH3 CBr CHE1.705 N N CH CH CH3 CBr NE1.706 N N CH CH CH3 CCH3 CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.707 N N CH CH CH3 CCH3 NE1.708 N N CH CH CH3 CCH2CH3 CHE1.709 N N CH CH CH3 CCH2CH3 NE1.710 N N CH CH CH3 CCN CHE1.711 N N CH CH CH3 CCN NE1.712 N N CH CH CH2OCH3 N CHE1.713 N N CH CH CH2OCH3 CH CHE1.714 N N CH CH CH2OCH3 CH NE1.715 N N CH CH CH2OCH3 CF CHE1.716 N N CH CH CH2OCH3 CF NE1.717 N N CH CH CH2OCH3 CCl CHE1.718 N N CH CH CH2OCH3 CCl NE1.719 N N CH CH CH2OCH3 CBr CHE1.720 N N CH CH CH2OCH3 CBr NE1.721 N N CH CH CH2OCH3 CCH3 CHE1.722 N N CH CH CH2OCH3 CCH3 NE1.723 N N CH CH CH2OCH3 CCH2CH3 CHE1.724 N N CH CH CH2OCH3 CCH2CH3 NE1.725 N N CH CH CH2OCH3 CCN CHE1.726 N N CH CH CH2OCH3 CCN NE1.727 N N CH CH CH2CH2OCH3 N CHE1.728 N N CH CH CH2CH2OCH3 CH CHE1.729 N N CH CH CH2CH2OCH3 CH NE1.730 N N CH CH CH2CH2OCH3 CF CHE1.731 N N CH CH CH2CH2OCH3 CF NE1.732 N N CH CH CH2CH2OCH3 CCl CHE1.733 N N CH CH CH2CH2OCH3 CCl NE1.734 N N CH CH CH2CH2OCH3 CBr CHE1.735 N N CH CH CH2CH2OCH3 CBr NE1.736 N N CH CH CH2CH2OCH3 CCH3 CHE1.737 N N CH CH CH2CH2OCH3 CCH3 NE1.738 N N CH CH CH2CH2OCH3 CCH2CH3 CHE1.739 N N CH CH CH2CH2OCH3 CCH2CH3 NE1.740 N N CH CH CH2CH2OCH3 CCN CHE1.741 N N CH CH CH2CH2OCH3 CCN NE1.742 N N CH CH CH2CN N CHE1.743 N N CH CH CH2CN CH CHE1.744 N N CH CH CH2CN CH NE1.745 N N CH CH CH2CN CF CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.746 N N CH CH CH2CN CF NE1.747 N N CH CH CH2CN CCl CHE1.748 N N CH CH CH2CN CCl NE1.749 N N CH CH CH2CN CBr CHE1.750 N N CH CH CH2CN CBr NE1.751 N N CH CH CH2CN CCH3 CHE1.752 N N CH CH CH2CN CCH3 NE1.753 N N CH CH CH2CN CCH2CH3 CHE1.754 N N CH CH CH2CN CCH2CH3 NE1.755 N N CH CH CH2CN CCN CHE1.756 N N CH CH CH2CN CCN NE1.757 N N CH CH allyl N CHE1.758 N N CH CH allyl CH CHE1.759 N N CH CH allyl CH NE1.760 N N CH CH allyl CF CHE1.761 N N CH CH allyl CF NE1.762 N N CH CH allyl CCl CHE1.763 N N CH CH allyl CCl NE1.764 N N CH CH allyl CBr CHE1.765 N N CH CH allyl CBr NE1.766 N N CH CH allyl CCH3 CHE1.767 N N CH CH allyl CCH3 NE1.768 N N CH CH allyl CCH2CH3 CHE1.769 N N CH CH allyl CCH2CH3 NE1.770 N N CH CH allyl CCN CHE1.771 N N CH CH allyl CCN NE1.772 N N CH N CH3 CH CHE1.773 N N CH N CH3 CF CHE1.774 N N CH N CH3 CCl CHE1.775 N N CH N CH3 CBr CHE1.776 N N CH N CH3 CCH3 CHE1.777 N N CH N CH3 CCH2CH3 CHE1.778 N N CH N CH3 CCN CHE1.779 N N CH N CH2OCH3 CH CHE1.780 N N CH N CH2OCH3 CF CHE1.781 N N CH N CH2OCH3 CCl CHE1.782 N N CH N CH2OCH3 CBr CHE1.783 N N CH N CH2OCH3 CCH3 CHE1.784 N N CH N CH2OCH3 CCH2CH3 CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.785 N N CH N CH2OCH3 CCN CHE1.786 N N CH N CH2CH2OCH3 CH CHE1.787 N N CH N CH2CH2OCH3 CF CHE1.788 N N CH N CH2CH2OCH3 CCl CHE1.789 N N CH N CH2CH2OCH3 CBr CHE1.790 N N CH N CH2CH2OCH3 CCH3 CHE1.791 N N CH N CH2CH2OCH3 CCH2CH3 CHE1.792 N N CH N CH2CH2OCH3 CCN CHE1.793 N N CH N CH2CN CH CHE1.794 N N CH N CH2CN CF CHE1.795 N N CH N CH2CN CCl CHE1.796 N N CH N CH2CN CBr CHE1.797 N N CH N CH2CN CCH3 CHE1.798 N N CH N CH2CN CCH2CH3 CHE1.799 N N CH N CH2CN CCN CHE1.800 N N CH N allyl CH CHE1.801 N N CH N allyl CF CHE1.802 N N CH N allyl CCl CHE1.803 N N CH N allyl CBr CHE1.804 N N CH N allyl CCH3 CHE1.805 N N CH N allyl CCH2CH3 CHE1.806 N N CH N allyl CCN CHE1.807 N N CH N CHE1.808 N N CH CH CHE1.809 N N CH CH NE1.810 N N CH CF CHE1.811 N N CH CF NE1.812 N N CH CCl CHCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.813 N N CH CCl NE1.814 N N CH CBr CHE1.815 N N CH CBr NE1.816 N N CH CCH3 CHE1.817 N N CH CCH3 NE1.818 N N CH CCH2CH3 CHE1.819 N N CH CCH2CH3 NE1.820 N N CH CCN CHE1.821 N N CH CCN NE1.822 N N CH N CHE1.823 N N CH CH CHE1.824 N N CH CH NCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.825 N N CH CF CHE1.826 N N CH CF NE1.827 N N CH CCl CHE1.828 N N CH CCl NE1.829 N N CH CBr CHE1.830 N N CH CBr NE1.831 N N CH CCH3 CHE1.832 N N CH CCH3 NE1.833 N N CH CCH2CH3 CHE1.834 N N CH CCH2CH3 NCompounds A1a A1b A1a’ A3 R4 A2a A2bE1.835 N N CH CCN CHE1.836 N N CH CCN NTable 1.2 provides compounds E2.1 to E2.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is H, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.3 provides compounds E3.1 to E3.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is H, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.4 provides compounds E4.1 to E4.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is H, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.5 provides compounds E5.1 to E5.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is H, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.6 provides compounds E6.1 to E6.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is CH3,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.7 provides compounds E7.1 to E7.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is CH3,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.8 provides compounds E8.1 to E8.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is CH3,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.9 provides compounds E9.1 to E9.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is CH3,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.10 provides compounds E10.1 to E10.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isCH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.11 provides compounds E11.1 to E11.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.12 provides compounds E12.1 to E12.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.13 provides compounds E13.1 to E13.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.14 provides compounds E14.1 to E14.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.15 provides compounds E15.1 to E15.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.16 provides compounds E16.1 to E16.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is F,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.17 provides compounds E17.1 to E17.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is F,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.18 provides compounds E18.1 to E18.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is F,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.19 provides compounds E19.1 to E19.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is F,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.20 provides compounds E20.1 to E20.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is F,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.21 provides compounds E21.1 to E21.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is Cl,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.22 provides compounds E22.1 to E22.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is Cl,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.23 provides compounds E23.1 to E23.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is Cl,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.24 provides compounds E24.1 to E24.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is Cl,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.25 provides compounds E25.1 to E25.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is Cl,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.26 provides compounds E26.1 to E26.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is Br,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.27 provides compounds E27.1 to E27.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is Br,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.28 provides compounds E28.1 to E28.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is Br,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.29 provides compounds E29.1 to E29.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is Br,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.30 provides compounds E30.1 to E30.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is Br,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.31 provides compounds E31.1 to E31.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is CN,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.32 provides compounds E32.1 to E32.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is CN,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.33 provides compounds E33.1 to E33.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is CN,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.34 provides compounds E34.1 to E34.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is CN,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.35 provides compounds E35.1 to E35.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 is CN,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.36 provides compounds E36.1 to E36.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isOCH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.37 provides compounds E37.1 to E37.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isOCH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.38 provides compounds E38.1 to E38.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isOCH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.39 provides compounds E39.1 to E39.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isOCH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.40 provides compounds E40.1 to E40.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isOCH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.41 provides compounds E41.1 to E41.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isOCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.42 provides compounds E42.1 to E42.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isOCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.43 provides compounds E43.1 to E43.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isOCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.44 provides compounds E44.1 to E44.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isOCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.45 provides compounds E45.1 to E45.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isOCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.46 provides compounds E46.1 to E46.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isCO2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.47 provides compounds E47.1 to E47.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isCO2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.48 provides compounds E48.1 to E48.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isCO2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.49 provides compounds E49.1 to E49.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isCO2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.50 provides compounds E50.1 to E50.836 of formula (Ia) wherein R1 is CH3, A1 is CH, R2 isCO2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.51 provides compounds E51.1 to E51.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is H,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.52 provides compounds E52.1 to E52.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is H,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.53 provides compounds E53.1 to E53.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is H,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.54 provides compounds E54.1 to E54.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is H,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.55 provides compounds E55.1 to E55.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is H,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.56 provides compounds E56.1 to E56.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is CH3,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.57 provides compounds E57.1 to E57.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is CH3,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.58 provides compounds E58.1 to E58.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is CH3,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.59 provides compounds E59.1 to E59.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is CH3,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.60 provides compounds E60.1 to E60.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is CH3,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.61 provides compounds E61.1 to E61.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 isCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.62 provides compounds E62.1 to E62.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 isCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.63 provides compounds E63.1 to E63.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 isCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.64 provides compounds E64.1 to E64.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 isCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.65 provides compounds E65.1 to E65.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 isCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.66 provides compounds E66.1 to E66.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is F, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.67 provides compounds E67.1 to E67.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is F, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.68 provides compounds E68.1 to E68.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is F, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.69 provides compounds E69.1 to E69.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is F, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.70 provides compounds E70.1 to E70.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is F, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.71 provides compounds E71.1 to E71.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is Cl,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.72 provides compounds E72.1 to E72.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is Cl,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.73 provides compounds E73.1 to E73.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is Cl,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.74 provides compounds E74.1 to E74.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is Cl,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.75 provides compounds E75.1 to E75.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is Cl,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.76 provides compounds E76.1 to E76.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is Br,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.77 provides compounds E77.1 to E77.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is Br,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.78 provides compounds E78.1 to E78.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is Br,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.79 provides compounds E79.1 to E79.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is Br,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.80 provides compounds E80.1 to E80.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is Br,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.81 provides compounds E81.1 to E81.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is CN,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.82 provides compounds E82.1 to E82.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is CN,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.83 provides compounds E83.1 to E83.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is CN,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.84 provides compounds E84.1 to E84.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is CN,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.85 provides compounds E85.1 to E85.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is CN,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.86 provides compounds E86.1 to E86.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is OCH3,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.87 provides compounds E87.1 to E87.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is OCH3,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.88 provides compounds E88.1 to E88.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is OCH3,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.89 provides compounds E89.1 to E89.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is OCH3,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.90 provides compounds E90.1 to E90.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 is OCH3,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.91 provides compounds E91.1 to E91.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 isOCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.92 provides compounds E92.1 to E92.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 isOCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.93 provides compounds E93.1 to E93.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 isOCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.94 provides compounds E94.1 to E94.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 isOCH2CH3, R5 is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2b are as defined in table Z.Table 1.95 provides compounds E95.1 to E95.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 isOCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.96 provides compounds E96.1 to E96.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 isCO2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.97 provides compounds E97.1 to E97.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 isCO2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.98 provides compounds E98.1 to E98.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 isCO2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.99 provides compounds E99.1 to E99.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 isCO2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.100 provides compounds E100.1 to E100.836 of formula (Ia) wherein R1 is CH3, A1 is N, R2 isCO2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.101 provides compounds E101.1 to E101.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is H, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.102 provides compounds E102.1 to E102.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is H, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.103 provides compounds E103.1 to E103.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is H, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.104 provides compounds E104.1 to E104.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is H, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.105 provides compounds E105.1 to E105.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is H, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.106 provides compounds E106.1 to E106.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2 is CH3, R5 is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2b are as defined in table Z.Table 1.107 provides compounds E107.1 to E107.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.108 provides compounds E108.1 to E108.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.109 provides compounds E109.1 to E109.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.110 provides compounds E110.1 to E110.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.111 provides compounds E111.1 to E111.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.112 provides compounds E112.1 to E112.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.113 provides compounds E113.1 to E113.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.114 provides compounds E114.1 to E114.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.115 provides compounds E115.1 to E115.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.116 provides compounds E116.1 to E116.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is F, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.117 provides compounds E117.1 to E117.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is F, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.118 provides compounds E118.1 to E118.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is F, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.119 provides compounds E119.1 to E119.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is F, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.120 provides compounds E120.1 to E120.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is F, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.121 provides compounds E121.1 to E121.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is Cl, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.122 provides compounds E122.1 to E122.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is Cl, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.123 provides compounds E123.1 to E123.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is Cl, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.124 provides compounds E124.1 to E124.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is Cl, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.125 provides compounds E125.1 to E125.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is Cl, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.126 provides compounds E126.1 to E126.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is Br, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.127 provides compounds E127.1 to E127.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is Br, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.128 provides compounds E128.1 to E128.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is Br, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.129 provides compounds E129.1 to E129.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is Br, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.130 provides compounds E130.1 to E130.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2 is Br, R5 is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2b are as defined in table Z.Table 1.131 provides compounds E131.1 to E131.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CN, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.132 provides compounds E132.1 to E132.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CN, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.133 provides compounds E133.1 to E133.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CN, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.134 provides compounds E134.1 to E134.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2 is CN, R5 is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2b are as defined in table Z.Table 1.135 provides compounds E135.1 to E135.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CN, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.136 provides compounds E136.1 to E136.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is OCH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.137 provides compounds E137.1 to E137.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is OCH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.138 provides compounds E138.1 to E138.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is OCH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.139 provides compounds E139.1 to E139.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is OCH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.140 provides compounds E140.1 to E140.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is OCH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.141 provides compounds E141.1 to E141.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is OCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.142 provides compounds E142.1 to E142.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is OCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.143 provides compounds E143.1 to E143.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is OCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.144 provides compounds E144.1 to E144.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is OCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.145 provides compounds E145.1 to E145.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is OCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.146 provides compounds E146.1 to E146.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CO2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.147 provides compounds E147.1 to E147.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CO2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.148 provides compounds E148.1 to E148.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CO2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.149 provides compounds E149.1 to E149.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CO2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.150 provides compounds E150.1 to E150.836 of formula (Ia) wherein R1 is CH2CH3, A1 is CH,R2is CO2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.151 provides compounds E151.1 to E151.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is H, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.152 provides compounds E152.1 to E152.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is H, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.153 provides compounds E153.1 to E153.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is H, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.154 provides compounds E154.1 to E154.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is H, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.155 provides compounds E155.1 to E155.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is H, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.156 provides compounds E156.1 to E156.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.157 provides compounds E157.1 to E157.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.158 provides compounds E158.1 to E158.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.159 provides compounds E159.1 to E159.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.160 provides compounds E160.1 to E160.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.161 provides compounds E161.1 to E161.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.162 provides compounds E162.1 to E162.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.163 provides compounds E163.1 to E163.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.164 provides compounds E164.1 to E164.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.165 provides compounds E165.1 to E165.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.166 provides compounds E166.1 to E166.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is F, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.167 provides compounds E167.1 to E167.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is F, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.168 provides compounds E168.1 to E168.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is F, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.169 provides compounds E169.1 to E169.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is F, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.170 provides compounds E170.1 to E170.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is F, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.171 provides compounds E171.1 to E171.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is Cl, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.172 provides compounds E172.1 to E172.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is Cl, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.173 provides compounds E173.1 to E173.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is Cl, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.174 provides compounds E174.1 to E174.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is Cl, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.175 provides compounds E175.1 to E175.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is Cl, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.176 provides compounds E176.1 to E176.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is Br, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.177 provides compounds E177.1 to E177.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is Br, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.178 provides compounds E178.1 to E178.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is Br, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.179 provides compounds E179.1 to E179.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is Br, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.180 provides compounds E180.1 to E180.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is Br, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.181 provides compounds E181.1 to E181.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CN, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.182 provides compounds E182.1 to E182.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CN, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.183 provides compounds E183.1 to E183.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CN, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.184 provides compounds E184.1 to E184.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CN, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.185 provides compounds E185.1 to E185.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CN, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.186 provides compounds E186.1 to E186.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is OCH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.187 provides compounds E187.1 to E187.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is OCH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.188 provides compounds E188.1 to E188.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is OCH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.189 provides compounds E189.1 to E189.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is OCH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.190 provides compounds E190.1 to E190.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is OCH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.191 provides compounds E191.1 to E191.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is OCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.192 provides compounds E192.1 to E192.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is OCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.193 provides compounds E193.1 to E193.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is OCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.194 provides compounds E194.1 to E194.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is OCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.195 provides compounds E195.1 to E195.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is OCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.196 provides compounds E196.1 to E196.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CO2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.197 provides compounds E197.1 to E197.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CO2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.198 provides compounds E198.1 to E198.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CO2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.199 provides compounds E199.1 to E199.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CO2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.200 provides compounds E200.1 to E200.836 of formula (Ia) wherein R1 is CH2CH3, A1 is N, R2is CO2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.201 provides compounds E201.1 to E201.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is H, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.202 provides compounds E202.1 to E202.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is H, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.203 provides compounds E203.1 to E203.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is H, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.204 provides compounds E204.1 to E204.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is H, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.205 provides compounds E205.1 to E205.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2 is H, R5 is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2b are as defined in table Z.Table 1.206 provides compounds E206.1 to E206.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.207 provides compounds E207.1 to E207.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.208 provides compounds E208.1 to E208.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.209 provides compounds E209.1 to E209.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.210 provides compounds E210.1 to E210.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.211 provides compounds E211.1 to E211.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.212 provides compounds E212.1 to E212.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.213 provides compounds E213.1 to E213.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.214 provides compounds E214.1 to E214.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.215 provides compounds E215.1 to E215.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.216 provides compounds E216.1 to E216.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is F, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.217 provides compounds E217.1 to E217.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is F, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.218 provides compounds E218.1 to E218.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is F, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.219 provides compounds E219.1 to E219.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is F, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.220 provides compounds E220.1 to E220.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2 is F, R5 is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2b are as defined in table Z.Table 1.221 provides compounds E221.1 to E221.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is Cl, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.222 provides compounds E222.1 to E222.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is Cl, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.223 provides compounds E223.1 to E223.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is Cl, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.224 provides compounds E224.1 to E224.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is Cl, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.225 provides compounds E225.1 to E225.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is Cl, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.226 provides compounds E226.1 to E226.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is Br, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.227 provides compounds E227.1 to E227.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is Br, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.228 provides compounds E228.1 to E228.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is Br, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.229 provides compounds E229.1 to E229.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is Br, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.230 provides compounds E230.1 to E230.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is Br, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.231 provides compounds E231.1 to E231.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CN, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.232 provides compounds E232.1 to E232.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CN, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.233 provides compounds E233.1 to E233.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CN, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.234 provides compounds E234.1 to E234.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CN, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.235 provides compounds E235.1 to E235.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CN, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.236 provides compounds E236.1 to E236.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is OCH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.237 provides compounds E237.1 to E237.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is OCH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.238 provides compounds E238.1 to E238.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is OCH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.239 provides compounds E239.1 to E239.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is OCH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.240 provides compounds E240.1 to E240.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is OCH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.241 provides compounds E241.1 to E241.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is OCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.242 provides compounds E242.1 to E242.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is OCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.243 provides compounds E243.1 to E243.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is OCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.244 provides compounds E244.1 to E244.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is OCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.245 provides compounds E245.1 to E245.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is OCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.246 provides compounds E246.1 to E246.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CO2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.247 provides compounds E247.1 to E247.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CO2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.248 provides compounds E248.1 to E248.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CO2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.249 provides compounds E249.1 to E249.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CO2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.250 provides compounds E250.1 to E250.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is CH,R2is CO2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.251 provides compounds E251.1 to E251.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is H, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.252 provides compounds E252.1 to E252.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is H, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.253 provides compounds E253.1 to E253.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is H, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.254 provides compounds E254.1 to E254.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is H, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.255 provides compounds E255.1 to E255.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is H, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.256 provides compounds E256.1 to E256.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2 is CH3, R5 is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2b are as defined in table Z.Table 1.257 provides compounds E257.1 to E257.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.258 provides compounds E258.1 to E258.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.259 provides compounds E259.1 to E259.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.260 provides compounds E260.1 to E260.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.261 provides compounds E261.1 to E261.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.262 provides compounds E262.1 to E262.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.263 provides compounds E263.1 to E263.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.264 provides compounds E264.1 to E264.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.265 provides compounds E265.1 to E265.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.266 provides compounds E266.1 to E266.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is F, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.267 provides compounds E267.1 to E267.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is F, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.268 provides compounds E268.1 to E268.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is F, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.269 provides compounds E269.1 to E269.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is F, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.270 provides compounds E270.1 to E270.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is F, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.271 provides compounds E271.1 to E271.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is Cl, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.272 provides compounds E272.1 to E272.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is Cl, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.273 provides compounds E273.1 to E273.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is Cl, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.274 provides compounds E274.1 to E274.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is Cl, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.275 provides compounds E275.1 to E275.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2 is Cl, R5 is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2b are as defined in table Z.Table 1.276 provides compounds E276.1 to E276.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is Br, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.277 provides compounds E277.1 to E277.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is Br, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.278 provides compounds E278.1 to E278.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is Br, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.279 provides compounds E279.1 to E279.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is Br, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.280 provides compounds E280.1 to E280.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2 is Br, R5 is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2b are as defined in table Z.Table 1.281 provides compounds E281.1 to E281.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CN, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.282 provides compounds E282.1 to E282.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CN, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.283 provides compounds E283.1 to E283.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CN, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.284 provides compounds E284.1 to E284.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2 is CN, R5 is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2b are as defined in table Z.Table 1.285 provides compounds E285.1 to E285.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CN, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.286 provides compounds E286.1 to E286.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is OCH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.287 provides compounds E287.1 to E287.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is OCH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.288 provides compounds E288.1 to E288.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is OCH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.289 provides compounds E289.1 to E289.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is OCH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.290 provides compounds E290.1 to E290.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is OCH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.291 provides compounds E291.1 to E291.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is OCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.292 provides compounds E292.1 to E292.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is OCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.293 provides compounds E293.1 to E293.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is OCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.294 provides compounds E294.1 to E294.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is OCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.295 provides compounds E295.1 to E295.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is OCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.296 provides compounds E296.1 to E296.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CO2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.297 provides compounds E297.1 to E297.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CO2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.298 provides compounds E298.1 to E298.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CO2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.299 provides compounds E299.1 to E299.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CO2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.300 provides compounds E300.1 to E300.836 of formula (Ia) wherein R1 is CH2OCH3, A1 is N,R2is CO2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.301 provides compounds E301.1 to E301.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is H, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.302 provides compounds E302.1 to E302.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is H, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.303 provides compounds E303.1 to E303.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is H, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.304 provides compounds E304.1 to E304.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is H, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.305 provides compounds E305.1 to E305.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is H, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.306 provides compounds E306.1 to E306.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.307 provides compounds E307.1 to E307.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.308 provides compounds E308.1 to E308.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.309 provides compounds E309.1 to E309.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.310 provides compounds E310.1 to E310.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.311 provides compounds E311.1 to E311.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.312 provides compounds E312.1 to E312.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.313 provides compounds E313.1 to E313.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.314 provides compounds E314.1 to E314.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.315 provides compounds E315.1 to E315.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.316 provides compounds E316.1 to E316.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is F, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.317 provides compounds E317.1 to E317.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is F, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.318 provides compounds E318.1 to E318.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is F, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.319 provides compounds E319.1 to E319.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is F, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.320 provides compounds E320.1 to E320.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is F, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.321 provides compounds E321.1 to E321.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is Cl, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.322 provides compounds E322.1 to E322.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is Cl, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.323 provides compounds E323.1 to E323.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is Cl, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.324 provides compounds E324.1 to E324.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is Cl, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.325 provides compounds E325.1 to E325.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is Cl, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.326 provides compounds E326.1 to E326.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is Br, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.327 provides compounds E327.1 to E327.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is Br, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.328 provides compounds E328.1 to E328.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is Br, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.329 provides compounds E329.1 to E329.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is Br, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.330 provides compounds E330.1 to E330.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is Br, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.331 provides compounds E331.1 to E331.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CN, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.332 provides compounds E332.1 to E332.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CN, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.333 provides compounds E333.1 to E333.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CN, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.334 provides compounds E334.1 to E334.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CN, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.335 provides compounds E335.1 to E335.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CN, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.336 provides compounds E336.1 to E336.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is OCH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.337 provides compounds E337.1 to E337.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is OCH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.338 provides compounds E338.1 to E338.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is OCH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.339 provides compounds E339.1 to E339.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is OCH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.340 provides compounds E340.1 to E340.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is OCH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.341 provides compounds E341.1 to E341.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is OCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.342 provides compounds E342.1 to E342.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is OCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.343 provides compounds E343.1 to E343.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is OCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.344 provides compounds E344.1 to E344.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is OCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.345 provides compounds E345.1 to E345.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is OCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.346 provides compounds E346.1 to E346.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CO2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.347 provides compounds E347.1 to E347.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CO2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.348 provides compounds E348.1 to E348.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CO2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.349 provides compounds E349.1 to E349.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CO2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.350 provides compounds E350.1 to E350.836 of formula (Ia) wherein R1 is cyclopropyl, A1 isCH, R2is CO2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.351 provides compounds E351.1 to E351.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is H, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.352 provides compounds E352.1 to E352.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is H, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.353 provides compounds E353.1 to E353.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is H, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.354 provides compounds E354.1 to E354.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is H, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.355 provides compounds E355.1 to E355.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is H, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.356 provides compounds E356.1 to E356.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.357 provides compounds E357.1 to E357.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.358 provides compounds E358.1 to E358.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.359 provides compounds E359.1 to E359.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.360 provides compounds E360.1 to E360.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.361 provides compounds E361.1 to E361.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.362 provides compounds E362.1 to E362.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.363 provides compounds E363.1 to E363.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.364 provides compounds E364.1 to E364.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.365 provides compounds E365.1 to E365.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.366 provides compounds E366.1 to E366.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is F, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.367 provides compounds E367.1 to E367.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is F, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.368 provides compounds E368.1 to E368.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is F, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.369 provides compounds E369.1 to E369.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is F, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.370 provides compounds E370.1 to E370.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is F, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.371 provides compounds E371.1 to E371.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is Cl, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.372 provides compounds E372.1 to E372.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is Cl, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.373 provides compounds E373.1 to E373.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is Cl, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.374 provides compounds E374.1 to E374.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is Cl, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.375 provides compounds E375.1 to E375.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is Cl, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.376 provides compounds E376.1 to E376.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is Br, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.377 provides compounds E377.1 to E377.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is Br, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.378 provides compounds E378.1 to E378.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is Br, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.379 provides compounds E379.1 to E379.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is Br, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.380 provides compounds E380.1 to E380.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is Br, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.381 provides compounds E381.1 to E381.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CN, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.382 provides compounds E382.1 to E382.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CN, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.383 provides compounds E383.1 to E383.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CN, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.384 provides compounds E384.1 to E384.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CN, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.385 provides compounds E385.1 to E385.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CN, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.386 provides compounds E386.1 to E386.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is OCH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.387 provides compounds E387.1 to E387.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is OCH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.388 provides compounds E388.1 to E388.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is OCH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.389 provides compounds E389.1 to E389.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is OCH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.390 provides compounds E390.1 to E390.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is OCH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.391 provides compounds E391.1 to E391.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is OCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.392 provides compounds E392.1 to E392.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is OCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.393 provides compounds E393.1 to E393.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is OCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.394 provides compounds E394.1 to E394.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is OCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.395 provides compounds E395.1 to E395.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is OCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.396 provides compounds E396.1 to E396.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CO2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.397 provides compounds E397.1 to E397.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CO2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.398 provides compounds E398.1 to E398.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CO2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.399 provides compounds E399.1 to E399.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CO2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.400 provides compounds E400.1 to E400.836 of formula (Ia) wherein R1 is cyclopropyl, A1 is N,R2is CO2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.401 provides compounds E401.1 to E401.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 is H,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.402 provides compounds E402.1 to E402.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 is H,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.403 provides compounds E403.1 to E403.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 is H,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.404 provides compounds E404.1 to E404.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 is H,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.405 provides compounds E405.1 to E405.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 is H,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.406 provides compounds E406.1 to E406.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.407 provides compounds E407.1 to E407.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.408 provides compounds E408.1 to E408.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.409 provides compounds E409.1 to E409.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.410 provides compounds E410.1 to E410.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.411 provides compounds E411.1 to E411.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.412 provides compounds E412.1 to E412.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.413 provides compounds E413.1 to E413.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.414 provides compounds E414.1 to E414.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.415 provides compounds E415.1 to E415.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.416 provides compounds E416.1 to E416.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 is F,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.417 provides compounds E417.1 to E417.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 is F,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.418 provides compounds E418.1 to E418.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 is F,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.419 provides compounds E419.1 to E419.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 is F,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.420 provides compounds E420.1 to E420.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 is F,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.421 provides compounds E421.1 to E421.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCl, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.422 provides compounds E422.1 to E422.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCl, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.423 provides compounds E423.1 to E423.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCl, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.424 provides compounds E424.1 to E424.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCl, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.425 provides compounds E425.1 to E425.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCl, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.426 provides compounds E426.1 to E426.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isBr, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.427 provides compounds E427.1 to E427.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isBr, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.428 provides compounds E428.1 to E428.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isBr, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.429 provides compounds E429.1 to E429.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isBr, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.430 provides compounds E430.1 to E430.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isBr, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.431 provides compounds E431.1 to E431.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCN, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.432 provides compounds E432.1 to E432.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCN, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.433 provides compounds E433.1 to E433.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCN, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.434 provides compounds E434.1 to E434.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCN, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.435 provides compounds E435.1 to E435.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCN, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.436 provides compounds E436.1 to E436.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isOCH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.437 provides compounds E437.1 to E437.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isOCH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.438 provides compounds E438.1 to E438.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isOCH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.439 provides compounds E439.1 to E439.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isOCH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.440 provides compounds E440.1 to E440.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isOCH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.441 provides compounds E441.1 to E441.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isOCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.442 provides compounds E442.1 to E442.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isOCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.443 provides compounds E443.1 to E443.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isOCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.444 provides compounds E444.1 to E444.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isOCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.445 provides compounds E445.1 to E445.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isOCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.446 provides compounds E446.1 to E446.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCO2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.447 provides compounds E447.1 to E447.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCO2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.448 provides compounds E448.1 to E448.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCO2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.449 provides compounds E449.1 to E449.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCO2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.450 provides compounds E450.1 to E450.836 of formula (Ia) wherein R1 is H, A1 is CH, R2 isCO2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.451 provides compounds E451.1 to E451.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is H,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.452 provides compounds E452.1 to E452.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is H,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.453 provides compounds E453.1 to E453.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is H,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.454 provides compounds E454.1 to E454.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is H,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.455 provides compounds E455.1 to E455.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is H,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.456 provides compounds E456.1 to E456.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is CH3,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.457 provides compounds E457.1 to E457.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is CH3,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.458 provides compounds E458.1 to E458.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is CH3,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.459 provides compounds E459.1 to E459.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is CH3,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.460 provides compounds E460.1 to E460.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is CH3,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.461 provides compounds E461.1 to E461.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.462 provides compounds E462.1 to E462.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.463 provides compounds E463.1 to E463.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.464 provides compounds E464.1 to E464.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.465 provides compounds E465.1 to E465.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.466 provides compounds E466.1 to E466.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is F,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.467 provides compounds E467.1 to E467.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is F,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.468 provides compounds E468.1 to E468.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is F,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.469 provides compounds E469.1 to E469.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is F,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.470 provides compounds E470.1 to E470.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is F,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.471 provides compounds E471.1 to E471.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is Cl,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.472 provides compounds E472.1 to E472.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is Cl,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.473 provides compounds E473.1 to E473.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is Cl,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.474 provides compounds E474.1 to E474.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is Cl,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.475 provides compounds E475.1 to E475.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is Cl,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.476 provides compounds E476.1 to E476.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is Br,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.477 provides compounds E477.1 to E477.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is Br,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.478 provides compounds E478.1 to E478.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is Br,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.479 provides compounds E479.1 to E479.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is Br,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.480 provides compounds E480.1 to E480.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is Br,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.481 provides compounds E481.1 to E481.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is CN,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.482 provides compounds E482.1 to E482.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is CN,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.483 provides compounds E483.1 to E483.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is CN,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.484 provides compounds E484.1 to E484.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is CN,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.485 provides compounds E485.1 to E485.836 of formula (Ia) wherein R1 is H, A1 is N, R2 is CN,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.486 provides compounds E486.1 to E486.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isOCH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.487 provides compounds E487.1 to E487.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isOCH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.488 provides compounds E488.1 to E488.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isOCH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.489 provides compounds E489.1 to E489.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isOCH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.490 provides compounds E490.1 to E490.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isOCH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.491 provides compounds E491.1 to E491.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isOCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.492 provides compounds E492.1 to E492.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isOCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.493 provides compounds E493.1 to E493.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isOCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.494 provides compounds E494.1 to E494.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isOCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.495 provides compounds E495.1 to E495.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isOCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.496 provides compounds E496.1 to E496.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isCO2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.497 provides compounds E497.1 to E497.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isCO2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.498 provides compounds E498.1 to E498.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isCO2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.499 provides compounds E499.1 to E499.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isCO2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.500 provides compounds E500.1 to E500.836 of formula (Ia) wherein R1 is H, A1 is N, R2 isCO2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.501 provides compounds E501.1 to E501.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isH, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.502 provides compounds E502.1 to E502.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isH, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.503 provides compounds E503.1 to E503.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isH, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.504 provides compounds E504.1 to E504.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isH, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.505 provides compounds E505.1 to E505.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isH, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.506 provides compounds E506.1 to E506.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.507 provides compounds E507.1 to E507.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.508 provides compounds E508.1 to E508.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.509 provides compounds E509.1 to E509.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.510 provides compounds E510.1 to E510.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.511 provides compounds E511.1 to E511.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.512 provides compounds E512.1 to E512.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.513 provides compounds E513.1 to E513.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.514 provides compounds E514.1 to E514.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.515 provides compounds E515.1 to E515.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCH2CH3, R5 is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2b are as defined in table Z.Table 1.516 provides compounds E516.1 to E516.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isF, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.517 provides compounds E517.1 to E517.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isF, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.518 provides compounds E518.1 to E518.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isF, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.519 provides compounds E519.1 to E519.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isF, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.520 provides compounds E520.1 to E520.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isF, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.521 provides compounds E521.1 to E521.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCl, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.522 provides compounds E522.1 to E522.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCl, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.523 provides compounds E523.1 to E523.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCl, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.524 provides compounds E524.1 to E524.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCl, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.525 provides compounds E525.1 to E525.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCl, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.526 provides compounds E526.1 to E526.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isBr, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.527 provides compounds E527.1 to E527.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isBr, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.528 provides compounds E528.1 to E528.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isBr, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.529 provides compounds E529.1 to E529.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isBr, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.530 provides compounds E530.1 to E530.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isBr, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.531 provides compounds E531.1 to E531.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCN, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.532 provides compounds E532.1 to E532.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCN, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.533 provides compounds E533.1 to E533.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCN, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.534 provides compounds E534.1 to E534.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCN, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.535 provides compounds E535.1 to E535.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCN, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.536 provides compounds E536.1 to E536.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isOCH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.537 provides compounds E537.1 to E537.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isOCH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.538 provides compounds E538.1 to E538.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isOCH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.539 provides compounds E539.1 to E539.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isOCH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.540 provides compounds E540.1 to E540.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isOCH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.541 provides compounds E541.1 to E541.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isOCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.542 provides compounds E542.1 to E542.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isOCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.543 provides compounds E543.1 to E543.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isOCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.544 provides compounds E544.1 to E544.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isOCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.545 provides compounds E545.1 to E545.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isOCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.546 provides compounds E546.1 to E546.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCO2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.547 provides compounds E547.1 to E547.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCO2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.548 provides compounds E548.1 to E548.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCO2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.549 provides compounds E549.1 to E549.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCO2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.550 provides compounds E550.1 to E550.836 of formula (Ia) wherein R1 is CN, A1 is CH, R2 isCO2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.551 provides compounds E551.1 to E551.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 is H,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.552 provides compounds E552.1 to E552.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 is H,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.553 provides compounds E553.1 to E553.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 is H,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.554 provides compounds E554.1 to E554.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 is H,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.555 provides compounds E555.1 to E555.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 is H,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.556 provides compounds E556.1 to E556.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.557 provides compounds E557.1 to E557.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.558 provides compounds E558.1 to E558.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.559 provides compounds E559.1 to E559.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.560 provides compounds E560.1 to E560.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.561 provides compounds E561.1 to E561.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.562 provides compounds E562.1 to E562.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.563 provides compounds E563.1 to E563.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.564 provides compounds E564.1 to E564.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.565 provides compounds E565.1 to E565.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.566 provides compounds E566.1 to E566.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 is F,R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.567 provides compounds E567.1 to E567.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 is F,R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.568 provides compounds E568.1 to E568.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 is F,R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.569 provides compounds E569.1 to E569.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 is F,R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.570 provides compounds E570.1 to E570.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 is F,R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.571 provides compounds E571.1 to E571.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCl, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.572 provides compounds E572.1 to E572.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCl, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.573 provides compounds E573.1 to E573.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCl, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.574 provides compounds E574.1 to E574.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCl, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.575 provides compounds E575.1 to E575.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCl, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.576 provides compounds E576.1 to E576.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isBr, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.577 provides compounds E577.1 to E577.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isBr, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.578 provides compounds E578.1 to E578.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isBr, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.579 provides compounds E579.1 to E579.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isBr, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.580 provides compounds E580.1 to E580.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isBr, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.581 provides compounds E581.1 to E581.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCN, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.582 provides compounds E582.1 to E582.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCN, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.583 provides compounds E583.1 to E583.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCN, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.584 provides compounds E584.1 to E584.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCN, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.585 provides compounds E585.1 to E585.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCN, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.586 provides compounds E586.1 to E586.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isOCH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.587 provides compounds E587.1 to E587.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isOCH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.588 provides compounds E588.1 to E588.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isOCH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.589 provides compounds E589.1 to E589.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isOCH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.590 provides compounds E590.1 to E590.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isOCH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.591 provides compounds E591.1 to E591.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isOCH2CH3, R5is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.592 provides compounds E592.1 to E592.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isOCH2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.593 provides compounds E593.1 to E593.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isOCH2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.594 provides compounds E594.1 to E594.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isOCH2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.595 provides compounds E595.1 to E595.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isOCH2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.596 provides compounds E596.1 to E596.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCO2CH3, R5 is CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2b are as defined in table Z.Table 1.597 provides compounds E597.1 to E597.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCO2CH3, R5is OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.598 provides compounds E598.1 to E598.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCO2CH3, R5is cyclopropyl and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.599 provides compounds E599.1 to E599.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCO2CH3, R5is CH2OCH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z.Table 1.600 provides compounds E600.1 to E600.836 of formula (Ia) wherein R1 is CN, A1 is N, R2 isCO2CH3, R5is NHCH2CH3 and A1a, A1b, A1a’, A3, R4, A2a, A2bare as defined in table Z. Compounds according to the invention may possess any number of benefits including, inter alia, advantageous levels of biological activity for protecting plants against diseases that are caused by fungi or superior properties for use as agrochemical active ingredients (for example, greater biological activity, an advantageous spectrum of activity, an increased safety profile, improved physico-chemicalproperties, or increased biodegradability). Compounds according to the invention have particularlyadvantageous levels of biological activity for protecting plants against oomycetes such as Phytophthora,Plasmopara and Pythium.Compounds of formula (I) can be made as shown in the following schemes 1 to 15, in which, unlessotherwise stated, the definition of each variable is as defined in the present invention. Compounds of formula (I) can be prepared via Suzuki cross coupling of compounds of formula (II), wherein X is Cl, Br or I, and a compound of formula (III), wherein either R6is independently from each other hydrogen, C1-6alkyl or wherein two R6together can form a C3-8cycloalkyl, in the presence of a base, such as Cs2CO3, K2CO3or NaOtBu, and a suitable palladium catalyst, such as tetrakistriphenylphosphinepalladium, [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II), bis(diphenylphosphine)palladium(II) chloride, palladium dichloride or palladium acetate, in a suitable solvent, such as dimethylformamide, dioxane, tetrahydrofuran, ethanol or water. Compounds of formula (III), wherein either R6 is independently from each other hydrogen, C1-6alkyl or wherein two R6 togethercan form a C3-8cycloalkyl are prepared by known methods or are commercially available. Thistransformation is depicted in Scheme 1. Compounds of formula (II) can be prepared by reacting compounds of formula (IV), wherein X is Cl, Br or I, with a reagent of formula (V), wherein X1 is a good leaving group such as Cl, Br, I, triflate, tosyl ormesyl, in the presence of a base such as such as Cs2CO3, K2CO3, NaH or NaOtBu. A compound of formula (VI), wherein R7 is an electron-withdrawing group such as a cyano or an ester, can alternativelybe used to functionalize the amide nitrogen. Compounds of formula (IV), wherein X is Cl, Br or I, can beprepared by a peptide-coupling reaction between a compound of formula (VII), wherein X are independently OH, Cl, Br or I, and an amine of formula (VIII), and by activating the carboxylic acid function of the compounds of formula (VII), a process that usually takes place by converting the -OH of the carboxylic acid into a good leaving group, such as a chloride group, for example by using (COCl)2 or SOCl2, prior to treatment with amines of formula (VIII), preferably in a suitable solvent (e.g., N- methylpyrrolidone, acetonitrile, dimethylacetamide, dichloromethane or tetrahydrofuran), preferably at temperatures between 25 °C and 60 °C, and optionally in the presence of a base such as triethylamineor N,N-diisopropylethylamine; or alternatively under conditions described in the literature for an amide coupling such as 1-propanephosphonic acid cyclic anhydride (T3P) in suitable solvent (e.g., acetonitrile) optionally in the presence of a base (e.g., triethylamine or N,N-diisopropylethylamine). For examples, see Chem. Soc. Rev.2009, 38, 606 and Chem. Soc. Rev.2011, 40, 5084. Alternatively, compounds offormula (II), wherein X is Cl, Br or I, can be obtained by an amide-coupling transformation betweencompounds of formula (VII), wherein X are independently Cl, Br or I, and amines of formula (IX) usingthe conditions described above. These transformations are depicted in Scheme 2. Compounds of formula (IX) are commercially available or can be obtained by reaction of compounds of formula (VIII) with a compound of formula (V) wherein X1is a good leaving group such as Cl, Br, I, triflate, tosyl or mesyl, in the presence of a base such as such as Cs2CO3, K2CO3, NaH or NaOtBu. Alternatively, compounds of formula (IX) can also be synthesized by reacting compounds of formula (VIII) with compounds of formula (VI), wherein R7is an electron-withdrawing group such as cyano or ester, optionally in the presence of a base such as triethylamine or 1,8-diazabicyclo[5.4.0]undec-7-ene. Alternatively, compounds of formula (IX) can be obtained from amines of formula (VIII) by a reductive amination with aldehydes of formula (X), wherein R8 forms a substituent R4 during the reduction of thealdehyde , e.g. in the presence of NaBH(OAc)3 or NaBH3CN, in a suitable solvent, optionally in thepresence of a Brønsted or Lewis acid such as acetic acid. Alternatively, another reagent system for the reductive amination uses a combination of titanium isopropoxide and NaBH4. The synthesis of compounds of formula (IX) from amines of formula (VIII) is depicted in Scheme 3. Alternatively, compounds of formula (II), wherein X is Cl, Br or I, can be prepared from the reaction of a compound of formula (XI) and a halogenating agent, such as N-chlorosuccinimide, N-bromosuccinimide, N-iodosuccinimide or bromine in a suitable solvent, such as dichloromethane, chloroform, tetrahydrofuran or acetonitrile. Compounds of formula (XI) can be obtained by an amide-coupling transformation of amines of formula (IX) with compounds of formula (XII), and by activating the carboxylic acid function of the compounds of formula (XII), a process that usually takes place by converting the -OH of the carboxylic acid into a good leaving group, such as a chloride group, for example by using (COCl)2 or SOCl2, prior to treatment with amines of formula (IX), preferably in asuitable solvent (e.g., N-methylpyrrolidone, acetonitrile, dimethylacetamide, dichloromethane or tetrahydrofuran), preferably at temperatures between 25 °C and 60 °C, and optionally in the presence of a base such as triethylamine or N,N-diisopropylethylamine; or alternatively under conditions described in the literature for an amide coupling such as 1-propanephosphonic acid cyclic anhydride (T3P) in suitable solvent (e.g., acetonitrile) optionally in the presence of a base (e.g., triethylamine or N,N-diisopropylethylamine). Alternatively, compounds of formula (XI) can be obtained by alkylation of compounds of formula (XIII) with compounds of formula (V), wherein X1is a good leaving group such as Cl, Br, I, triflate, tosyl or mesyl, in the presence of a base such as such as Cs2CO3, K2CO3, NaH or NaOtBu. Alternatively, compounds of formula (XI) can also be synthesized by reacting compounds offormula (XIII) with compounds of formula (VI), wherein R7is an electron-withdrawing group such as cyano or ester, optionally in the presence of a base such as triethylamine or 1,8- diazabicyclo[5.4.0]undec-7-ene. Compounds of formula (XIII) can be prepared by a peptide-coupling transformation from compounds of formula (XII) with amines of formula (VIII) using the conditionsdescribed above. These transformations are depicted in Scheme 4. Compounds of formula (VIIa), wherein X are independently Cl, Br or I, can be prepared by reactingcompounds of formula (XIV) with a halogenating agent such as phosphorus oxychloride, thionyl chloride or phosphorus tribromide. Compounds of formula (XIVa) can be obtained by cyclization of alkynes of formula (XV), wherein R9is C1-6alkyl, using a diazotization reagent such as sodium nitrite in the presence of an acid such as hydrochloric acid or sulfuric acid. Alkynes of formula (XV), wherein R9 is C1-6alkyl,can be prepared by cross-coupling between a compound of formula (XVI), wherein R9is C1-6alkyl andX is Cl, Br or I, and ethynyltrimethylsilane (formula (XVII)). Such transformations occur in the presenceof a palladium catalyst such as palladium acetate or bis(triphenylphosphine)palladium(II)-chloride, acopper catalyst such as copper iodide or copper bromide, and a base such as triethylamine ordiisopropylamine. Compounds of formula (XVI), wherein R9 is C1-6alkyl, and X is Cl, Br or I, arecommercially available or can be synthesized from compounds of formula (XVIII), wherein R9is C1-6alkyl, using a halogenating agent such as N-chlorosuccinimide or iodine, optionally in the presence ofa base. Compounds of formula (XVIII), wherein R9 is C1-6alkyl, are commercially available or can beprepared by those skilled in the art following published methods. Alternatively, compounds of formula(XIVa) can be prepared by carbonylation from compounds of formula (XIX), wherein X is Cl, Br or I, inthe presence of a catalyst such as [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium ordichlorobis(triphenylphosphine)palladium, in the presence of carbon monoxide, a base such as triethylamine or sodium carbonate and an alcohol. Compounds of formula (XIX), wherein X is Cl, Br or I, can be obtained by cyclization of alkynes of formula (XX), wherein X is Cl, Br or I, using a diazotization reagent such as sodium nitrite in the presence of an acid such as hydrochloric acid or sulfuric acid. Compounds of formula (XX), wherein X is Cl, Br or I, can be prepared by cross-coupling between a compound of formula (XXI), wherein X are independently selected from Cl, Br or I, and ethynyltrimethylsilane (formula (XVII)). Such transformations occur in the presence of a palladium catalyst such as palladium acetate or bis(triphenylphosphine)palladium(II)-chloride, a copper catalyst such as copper iodide or copper bromide, and a base such as triethylamine or diisopropylamine. Compounds of formula (XXI), wherein X are independently selected from Cl, Br or I, are commercially available or can be prepared by those skilled in the art following published methods. These transformations are depicted in Scheme 5. Scheme 5 Compounds of formula (VIIb), wherein X is Cl, Br or I, can be prepared by hydrolysis of compounds of formula (XXIIb), wherein X is Cl, Br or I, and R9is C1-6alkyl, for instance in the presence of a base suchas lithium hydroxide or sodium hydroxide. Compounds of formula (XXIIb), wherein X is Cl, Br or I, canbe prepared by reacting compounds of formula (XXIIIb), wherein R9 is C1-6alkyl, with a halogenatingagent such as phosphorus oxychloride, thionyl chloride or phosphorus tribromide. Compounds offormula (XXIIIb), wherein R9is C1-6alkyl, can be obtained by carbonylation of compounds of formula (XXIVb), wherein X is Cl, Br or I, in the presence of a catalyst such as [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium or dichlorobis(triphenylphosphine)palladium, in thepresence of carbon monoxide, a base such as triethylamine or sodium carbonate and an alcohol. Compounds of formula of formula (XXIVb), wherein X is Cl, Br or I, can be obtained by reactingcompounds of formula (XXV), wherein R9 is hydrogen or C1-6alkyl, and wherein X are independently Cl,Br or I, with hydrazine hydrate in a suitable solvent such as water, acetonitrile or ethanol. Compoundsof formula (XXV), wherein R9is hydrogen or C1-6alkyl, and wherein X are independently Cl, Br or I, canbe synthesized by reacting compounds of formula (XXVI), wherein R9 is C1-6alkyl, and X is Cl, Br or I,with a radical initiator such as benzoyl peroxide or 2,2′-azobis(2-methylpropionitrile), a halogenatingreagent such as N-bromosuccinimide or 1,3-dichloro-5,5-dimethylhydantoin in a suitable solvent suchas carbon tetrachloride or chlorobenzene. Alternatively, treatment of compounds of formula (XXVII),wherein X are independently Cl, Br or I, with hydrazine hydrate will provide compounds of formula(XXIVb), wherein X is Cl, Br or I. Compounds of formula (XXVII), wherein X are independently Cl, Br orI, can be obtained by reacting compounds of formula (XXVIII), wherein X are independently Cl, Br or I, and R9is C1-6alkyl, with a radical initiator such as benzoyl peroxide or 2,2′-azobis(2-methylpropionitrile),a halogenating reagent such as N-bromosuccinimide or 1,3-dichloro-5,5-dimethylhydantoin in a suitablesolvent such as carbon tetrachloride or chlorobenzene. Compounds of formula (XXVIII), wherein X areindependently Cl, Br or I, and R9 is C1-6alkyl, can be synthesized by reacting compounds of formula(XXVI), wherein X is Cl, Br or I, and R9is C1-6alkyl, with a radical initiator such as benzoyl peroxide or2,2′-azobis(2-methylpropionitrile), a halogenating reagent such as N-bromosuccinimide or 1,3-dichloro-5,5-dimethylhydantoin in a suitable solvent such as carbon tetrachloride or chlorobenzene. Thesetransformations are depicted in Scheme 6.

[0003] Compounds of formula (VIIc), wherein X is Cl, Br or I, can be prepared from compounds of formula(XXIXc) using a halogenating agent such as N-chlorosuccinimide, or bromine in acetic acid. Compoundsof formula (XXIXc) are commercially available or can be prepared by reaction of compounds of formula(XXX), with a compound of formula (XXXI) or a salt thereof, in the presence of a base such as sodiumhydroxide or potassium hydroxide. Compounds of formula (XXX) are commercially available or can beprepared following methods known to those skilled in the art. These transformations are depicted in Scheme 7. Scheme 7 Compounds of formula (VIId), wherein X is Cl, Br or I, are commercially available or can be prepared by hydrolysis of compounds of formula (XXIId), wherein X is Cl, Br or I, and R9is C1-6alkyl, for instance in the presence of a base such as lithium hydroxide or sodium hydroxide. Compounds of formula (XXIId),wherein X is Cl, Br or I, and R9 is C1-6alkyl, can be synthesized from compounds of formula (XXXII) usinga halogenating reagent such as N-chlorosuccinimide or N-bromosuccinimide, optionally in the presence of an acid such as acetic acid. Compounds of formula (XXXII) can be obtained by carbonylation of compounds of formula (XXXIII), wherein X is Cl, Br or I, in the presence of a catalyst such as [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium or dichlorobis(triphenylphosphine)palladium, in thepresence of carbon monoxide, a base such as triethylamine or sodium carbonate and an alcohol.Compounds of formula (XXXIII), wherein X is Cl, Br or I, are commercially available or can be preparedby methods known to those skilled in the art. These transformations are depicted in Scheme 8. Compounds of formula (VIIe), wherein X is Cl, Br or I, are commercially available or can be prepared by hydrolysis of compounds of formula (XXIIe), wherein X is Cl, Br or I, and R9is C1-6alkyl, for instance inthe presence of a base such as lithium hydroxide or sodium hydroxide. Compounds of formula (XXIIe),wherein X is Cl, Br or I, and R9is C1-6alkyl, can be synthesized from compounds of formula (XXXIIe),wherein R9 is C1-6alkyl, using a halogenating reagent such as N-chlorosuccinimide or N-bromosuccinimide, optionally in the presence of an acid such as acetic acid. Compounds of formula(XXXIIe), wherein R9is C1-6alkyl, can be synthesized from compounds of formula (XXXV), wherein X is Cl, Br or I, and R9is C1-6alkyl, by using methods such as cross-coupling reactions known to those skilledin the art. Compounds of formula (XXXV), wherein X is Cl, Br or I, and R9 is C1-6alkyl, can be synthesizedfrom compounds of formula (XXXVI), wherein R9 is C1-6alkyl, using a halogenating reagent such as asN-chlorosuccinimide or N-bromosuccinimide, optionally in the presence of an acid such as acetic acid. Compounds of formula (XXXVI), wherein R9is C1-6alkyl, can be prepared by reacting a compound offormula (XXXVII) with compounds of formula (XXXVIII), wherein R9 is C1-6alkyl, in the presence of abase such as potassium tert-butoxide or sodium tert-butoxide followed by an aqueous acid treatment.These transformations are depicted in Scheme 9. Alternatively, compounds of formula (I) can be prepared by an amide-coupling transformation of aminesof formula (IX) with compounds of formula (XXXIX), wherein X2 is OH or Cl, and optionally by activatingthe carboxylic acid function of the compounds of formula (XXXIX), a process that usually takes place by converting the -OH of the carboxylic acid into a good leaving group, such as a chloride group, for example by using (COCl)2 or SOCl2, prior to treatment with amines of formula (IX), preferably in a suitable solvent (e.g., N-methylpyrrolidone, acetonitrile, dimethylacetamide, dichloromethane or tetrahydrofuran), preferably at temperatures between 25 °C and 60 °C, and optionally in the presence of a base such as triethylamine or N,N-diisopropylethylamine; or alternatively under conditions described in the literature for an amide coupling such as 1-propanephosphonic acid cyclic anhydride(T3P) in suitable solvent (e.g., acetonitrile) optionally in the presence of a base (e.g., triethylamine orN,N-diisopropylethylamine). Compounds of formula (I) can alternatively be prepared by alkylation of compounds of formula (XL) with compounds of formula (V), wherein X1is a good leaving group such as Cl, Br, I, triflate, tosyl or mesyl, in the presence of a base such as such as Cs2CO3, K2CO3, NaH orNaOtBu. Alternatively, compounds of formula (I) can also be synthesized by reacting compounds offormula (XL) with compounds of formula (VI), wherein R7is an electron-withdrawing group such as cyano or ester, optionally in the presence of a base such as triethylamine or 1,8-diazabicyclo[5.4.0]undec-7- ene. Compounds of formula (XL) can be synthesized by a peptide-coupling transformation fromcompounds of formula (XXXIX) and amines of formula (VIII) using the conditions described above.These transformations are depicted in Scheme 10. Compounds of formula (XXXIX), wherein X2is OH, can be prepared by hydrolysis of esters of formula (XLI), wherein R9is C1-6alkyl, for instance in the presence of a base such as lithium hydroxide or sodium hydroxide. Compounds formula (XLI), wherein R9is C1-6alkyl, can be synthesized via Suzuki crosscoupling of compounds of formula (XXII), wherein X is Cl, Br or I, and wherein R9 is C1-6alkyl, and acompound of formula (III), wherein either R6is independently from each other hydrogen, C1-6alkyl or wherein two R6together can form a C3-8cycloalkyl, in the presence of a base, such as Cs2CO3, K2CO3 or NaOtBu, and a suitable palladium catalyst, such as tetrakistriphenylphosphinepalladium, [1,1- bis(diphenylphosphino)ferrocene]dichloropalladium(II), bis(diphenylphosphine)palladium(II) chloride, palladium dichloride or palladium acetate, in a suitable solvent, such as dimethylformamide, dioxane,tetrahydrofuran, ethanol or water. Compounds of formula (XXII), wherein X is Cl, Br or I, and whereinR9is C1-6alkyl, can be obtained by halogenation of compounds of formula (XXXII), wherein R9is C1- 6alkyl, using a halogenating reagent such as N-chlorosuccinimide or N-bromosuccinimide. Compounds of formula (XXXII), wherein R9is C1-6alkyl, can be prepared by carbonylation of compounds of formula(XLII), wherein X is Cl, Br or I, in the presence of a catalyst such as [1,1′-bis(diphenylphosphino)ferrocene]dichloropalladium or dichlorobis(triphenylphosphine)palladium, in thepresence of carbon monoxide, a base such as triethylamine or sodium carbonate and an alcohol.Compounds of formula (XXII), wherein X is Cl, Br or I, and wherein R9 is C1-6alkyl, can be hydrolyzed toacids of formula (XII), for instance in the presence of a base such as lithium hydroxide or sodium hydroxide. These transformations are depicted in Scheme 11. Alternatively, compounds of formula (I) can be prepared by aminocarbonylation between compounds offormula (XLIII), wherein X is Cl, Br or I, amines of formula (IX) and carbon monoxide, in the presence ofa catalyst such as [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II) or [(4,5-bis(diphenylphosphino)-9,9-dimethylxanthene)-2-(2′-amino-1,1′-biphenyl)]palladium(II)methanesulfonate, and, optionally, a base such as triethylamine or sodium carbonate. Compounds offormula (XLIII), wherein X is Cl, Br or I, can be synthesized via Suzuki cross coupling of compounds offormula (XLIV), wherein X are independently selected from Cl, Br or I, and a compound of formula (III),wherein either R6is independently from each other hydrogen, C1-6alkyl or wherein two R6together can form a C3-8cycloalkyl, in the presence of a base, such as Cs2CO3, K2CO3 or NaOtBu, and a suitable palladium catalyst, such as tetrakistriphenylphosphinepalladium, [1,1- bis(diphenylphosphino)ferrocene]dichloropalladium(II), bis(diphenylphosphine)palladium(II) chloride, palladium dichloride or palladium acetate, in a suitable solvent, such as dimethylformamide, dioxane,tetrahydrofuran, ethanol or water. Compounds of formula (XLIV), wherein X are independently selectedfrom Cl, Br or I, can be prepared by halogenation of compounds of formula (XLV), wherein X is Cl, Br or I, for instance using a reagent such as bromine in acetic acid or N-chlorosuccinimide. Alternatively, compounds of formula (XLIV), wherein X are independently selected from Cl, Br or I, can be synthesizedfrom compounds of formula (XLVI), wherein X is Cl, Br or I, using a reagent such as phosphorus oxychloride, thionyl chloride or phosphorus tribromide. These transformations are depicted in Scheme12. Alternatively, compounds of formula (I) can be prepared by acylation of compounds of formula (XLVII),wherein X2 is OH or Cl, in a peptide-coupling transformation, using the conditions described above.Compounds of formula (XLVII) can be synthesized via Suzuki cross coupling of compounds of formula (II), wherein X is Cl, Br or I, and a compound of formula (XLIX), wherein either R6 is independently fromeach other hydrogen, C1-6alkyl or wherein two R6together can form a C3-8cycloalkyl, in the presence of a base, such as Cs2CO3, K2CO3 or NaOtBu, and a suitable palladium catalyst, such as tetrakistriphenylphosphinepalladium, [1,1-bis(diphenylphosphino)ferrocene]dichloropalladium(II), bis(diphenylphosphine)palladium(II) chloride, palladium dichloride or palladium acetate, in a suitablesolvent, such as dimethylformamide, dioxane, tetrahydrofuran, ethanol or water. These transformationsare depicted in Scheme 13. Compounds of formula (Ib), wherein Z is S, can be prepared by the reaction of a compound of formula (I), wherein Z is O, with phosphorus pentasulfide or Lawesson’s reagent (CAS: 19172-47-5) in a suitable solvent such as toluene, xylene or dichloromethane. This transformation is depicted in Scheme 14. Alternatively, compounds of formula (Ib), wherein Z is S, can be prepared by the reaction of a compound of formula (XLVIIb) with compounds of formula (XLVIII), wherein X2 is OH or Cl, in a peptide-couplingtransformation, using the conditions described above. Compounds of formula (XLVIIb) can be prepared by the reaction of a compound of formula (XLVII), with phosphorus pentasulfide or Lawesson’s reagent (CAS: 19172-47-5) in a suitable solvent such as toluene, xylene or dichloromethane. This transformation is depicted in Scheme 15. When the term “compound / compounds according to the invention” is used, then this refers to compounds according to the present invention. Alternatively, the compounds according to the present invention can be obtained by using standardsynthesis techniques known to the person skilled in the art. Non-exhaustive examples include oxidationreactions, reduction reactions, hydrolysis reactions, coupling reactions, aromatic nucleophilic or electrophilic substitution reactions, nucleophilic substitution reactions, nucleophilic addition reactions, olefination reactions, oxime formation, alkylation and halogenation reactions. Acompound according to the present invention can be converted in a manner known per se into anothercompound according to the present invention by replacing one or more substituents of the startingcompound according to the present invention in the customary manner by (an)other substituent(s)according to the invention. Depending on the choice of the reaction conditions and starting materials which are suitable in each case, it is possible, for example, in one reaction step only to replace one substituent by another substituent according to the invention, or a plurality of substituents can be replaced by other substituents according to the invention in the same reaction step. Salts of the compounds according to the present invention can be prepared in a manner known per se.Thus, for example, acid addition salts of the compounds according to the present invention are obtainedby treatment with a suitable acid or a suitable ion exchanger reagent and salts with bases are obtained by treatment with a suitable base or with a suitable ion exchanger reagent. Salts of compounds the compounds according to the present invention can be converted in thecustomary manner into the free compounds, acid addition salts, for example, by treatment with a suitable basic compound or with a suitable ion exchanger reagent and salts with bases, for example, by treatment with a suitable acid or with a suitable ion exchanger reagent.Salts of the compounds according to the present invention can be converted in a manner known per seinto other salts of the compounds according to the present invention, acid addition salts, for example, into other acid addition salts, for example by treatment of a salt of inorganic acid such as hydrochloride with a suitable metal salt such as a sodium, barium or silver salt, of an acid, for example with silver acetate, in a suitable solvent in which an inorganic salt which forms, for example silver chloride, is insoluble and thus precipitates from the reaction mixture.Depending on the procedure or the reaction conditions, the compounds according to the presentinvention, which have salt-forming properties can be obtained in free form or in the form of salts.The compounds according to the present invention and, where appropriate, the tautomers thereof, ineach case in free form or in salt form, can be present in the form of one of the stereoisomers which are possible or as a mixture of these, for example in the form of pure stereoisomers, such as antipodes and / or diastereomers, or as stereoisomer mixtures, such as enantiomer mixtures, for exampleracemates, diastereomer mixtures or racemate mixtures, depending on the number, absolute andrelative configuration of asymmetric carbon atoms which occur in the molecule and / or depending on the configuration of non-aromatic double bonds which occur in the molecule; the invention relates to the pure stereoisomers and also to all stereoisomer mixtures which are possible and is to be understood in each case in this sense hereinabove and hereinbelow, even when stereochemical details are not mentioned specifically in each case. Diastereomer mixtures or racemate mixtures of the compounds according to the present invention, in free form or in salt form, which can be obtained depending on which starting materials and procedures have been chosen can be separated in a known manner into the pure diastereomers or racemates on the basis of the physicochemical differences of the components, for example by fractional crystallization, distillation and / or chromatography. Enantiomer mixtures, such as racemates, which can be obtained in a similar manner can be resolved into the optical antipodes by known methods, for example by recrystallization from an optically active solvent, by chromatography on chiral adsorbents, for example high-performance liquid chromatography (HPLC) on acetyl cellulose, with the aid of suitable microorganisms, by cleavage with specific, immobilized enzymes, via the formation of inclusion compounds, for example using chiral crown ethers, where only one enantiomer is complexed, or by conversion into diastereomeric salts, for example by reacting a basic end-product racemate with an optically active acid, such as a carboxylic acid, for example camphor, tartaric or malic acid, or sulfonic acid, for example camphorsulfonic acid, and separating the diastereomer mixture which can be obtained in this manner, for example by fractional crystallization based on their differing solubilities, to give the diastereomers, from which the desired enantiomer can be set free by the action of suitable agents, for example basic agents. Pure diastereomers or enantiomers can be obtained according to the invention not only by separating suitable stereoisomer mixtures, but also by generally known methods of diastereoselective or enantioselective synthesis, for example by carrying out the process according to the invention with starting materials of a suitable stereochemistry.N-oxides can be prepared by reacting a compound according to the present invention with a suitableoxidizing agent, for example the H2O2 / urea adduct in the presence of an acid anhydride, e.g. trifluoroacetic anhydride. Such oxidations are known from the literature, for example from J. Med. Chem., 32 (12), 2561-73, 1989 or WO 00 / 15615. It is advantageous to isolate or synthesize in each case the biologically more effective stereoisomer, for example enantiomer or diastereomer, or stereoisomer mixture, for example enantiomer mixture or diastereomer mixture, if the individual components have a different biological activity.The compounds according to the present invention and, where appropriate, the tautomers thereof, ineach case in free form or in salt form, can, if appropriate, also be obtained in the form of hydrates and / or include other solvents, for example those which may have been used for the crystallization of compounds which are present in solid form. The following Examples illustrate, but do not limit, the invention.The compounds of formula (I) as defined in the present invention can be used in the agricultural sectorand related fields of use e.g. as active ingredients for controlling plant pathogens or on non-living materials for control of spoilage microorganisms or organisms potentially harmful to man. The novel compounds are distinguished by excellent activity at low rates of application, by being well tolerated by plants and by being environmentally safe. They have very useful curative, preventive and systemic properties and may be used for protecting numerous cultivated plants. The compounds of formula (I) asdefined in the present invention can be used to inhibit or destroy the pathogens that occur on plants orparts of plants (fruit, blossoms, leaves, stems, tubers, roots) of different crops of useful plants, while at the same time protecting also those parts of the plants that grow later e.g. from phytopathogenic microorganisms.It is also possible to use compounds of formula (I) as defined in the present invention as fungicide. Theterm “fungicide” as used herein means a compound that controls, modifies, or prevents the growth of fungi. The term “fungicidally effective amount” means the quantity of such a compound or combination of such compounds that is capable of producing an effect on the growth of fungi. Controlling or modifying effects include all deviation from natural development, such as killing, retardation and the like, and prevention includes barrier or other defensive formation in or on a plant to prevent fungal infection.It is also possible to use compounds of formula (I) as defined in the present invention as dressing agentsfor the treatment of plant propagation material, e.g., seed, such as fruits, tubers or grains, or plant cuttings (for example rice), for the protection against fungal infections as well as against phytopathogenic fungi occurring in the soil. The propagation material can be treated with a compositioncomprising a compound of formula (I) as defined in the present invention before planting: seed, forexample, can be dressed before being sown. The compounds of formula (I) as defined in the presentinvention can also be applied to grains (coating), either by impregnating the seeds in a liquid formulation or by coating them with a solid formulation. The composition can also be applied to the planting site when the propagation material is being planted, for example, to the seed furrow during sowing. The invention relates also to such methods of treating plant propagation material and to the plant propagation material so treated.Furthermore the compounds of formula (I) as defined in the present invention can be used for controllingfungi in related areas, for example in the protection of technical materials, including wood and wood related technical products, in food storage, in hygiene management. In addition, the invention could be used to protect non-living materials from fungal attack, e.g. lumber, wall boards and paint.Compounds of formula (I) as defined in the present invention and fungicidal compositions containingthem may be used to control plant diseases caused by a broad spectrum of fungal plant pathogens. They are effective in controlling a broad spectrum of plant diseases, such as foliar pathogens of ornamental, turf, vegetable, field, cereal, and fruit crops. These fungi and fungal vectors of disease, as well as phytopathogenic bacteria and viruses, which may be controlled are for example:Absidia corymbifera, Alternaria spp, Aphanomyces spp, Ascochyta spp, Aspergillus spp. including A.flavus, A. fumigatus, A. nidulans, A. niger, A. terrus, Aureobasidium spp. including A. pullulans,Blastomyces dermatitidis, Blumeria graminis, Bremia lactucae, Botryosphaeria spp. including B. dothidea, B. obtusa, Botrytis spp. inclusing B. cinerea, Candida spp. including C. albicans, C. glabrata,C. krusei, C. lusitaniae, C. parapsilosis, C. tropicalis, Cephaloascus fragrans, Ceratocystis spp,Cercospora spp. including C. arachidicola, Cercosporidium personatum, Cladosporium spp, Claviceps purpurea, Coccidioides immitis, Cochliobolus spp, Colletotrichum spp. including C. musae,Cryptococcus neoformans, Diaporthe spp, Didymella spp, Drechslera spp, Elsinoe spp,Epidermophyton spp, Erwinia amylovora, Erysiphe spp. including E. cichoracearum,Eutypa lata, Fusarium spp. including F. culmorum, F. graminearum, F. langsethiae, F. moniliforme, F.oxysporum, F. proliferatum, F. subglutinans, F. solani, Gaeumannomyces graminis, Gibberella fujikuroi,Gloeodes pomigena, Gloeosporium musarum, Glomerella cingulate, Guignardia bidwellii, Gymnosporangium juniperi-virginianae, Helminthosporium spp, Hemileia spp, Histoplasma spp. including H. capsulatum, Laetisaria fuciformis, Leptographium lindbergi, Leveillula taurica, Lophodermium seditiosum, Microdochium nivale, Microsporum spp, Monilinia spp, Mucor spp, Mycosphaerella spp. including M. graminicola, M. pomi, Oncobasidium theobromaeon, Ophiostoma piceae, Paracoccidioides spp, Penicillium spp. including P. digitatum, P. italicum, Petriellidium spp, Peronosclerospora spp. Including P. maydis, P. philippinensis and P. sorghi, Peronospora spp, Phaeosphaeria nodorum, Phakopsora pachyrhizi, Phellinus igniarus, Phialophora spp, Phoma spp, Phomopsis viticola, Phytophthora spp. including P. infestans, Plasmopara spp. including P. halstedii, P. viticola, Pleospora spp., Podosphaera spp. including P. leucotricha, Polymyxa graminis, Polymyxa betae, Pseudocercosporella herpotrichoides, Pseudomonas spp, Pseudoperonospora spp. including P. cubensis, P. humuli, Pseudopeziza tracheiphila, Puccinia Spp. including P. hordei, P. recondita, P. striiformis, P. triticina, Pyrenopeziza spp, Pyrenophora spp, Pyricularia spp. including P. oryzae, Pythiumspp. including P. ultimum, Ramularia spp, Rhizoctonia spp, Rhizomucor pusillus, Rhizopus arrhizus,Rhynchosporium spp, Scedosporium spp. including S. apiospermum and S. prolificans, Schizothyrium pomi, Sclerotinia spp, Sclerotium spp, Septoria spp, including S. nodorum, S. tritici, Sphaerotheca macularis, Sphaerotheca fusca (Sphaerotheca fuliginea), Sporothorix spp, Stagonospora nodorum, Stemphylium spp, Stereum hirsutum, Thanatephorus cucumeris, Thielaviopsis basicola, Tilletia spp, Trichoderma spp. including T. harzianum, T. pseudokoningii, T. viride, Trichophyton spp, Typhula spp, Uncinula necator, Urocystis spp, Ustilago spp, Venturia spp. including V. inaequalis, Verticillium spp, and Xanthomonas spp.In particular, compounds of formula (I) as defined in the present invention and fungicidal compositionscontaining them may be used to control plant diseases caused by a broad spectrum of fungal plant pathogens in the Basidiomycete, Ascomycete, Oomycete and / or Deuteromycete, Blasocladiomycete,Chrytidiomycete, Glomeromycete and / or Mucoromycete classes. More particularly, the compounds offormula (I) as defined in the present invention may be used to conrol oomycetes.These pathogens may include:Oomycetes, including Phytophthora diseases such as those caused by Phytophthora capsici,Phytophthora infestans, Phytophthora sojae, Phytophthora fragariae, Phytophthora nicotianae,Phytophthora cinnamomi, Phytophthora citricola, Phytophthora citrophthora and Phytophthoraerythroseptica; Pythium diseases such as those caused by Pythium aphanidermatum, Pythiumarrhenomanes, Pythium graminicola, Pythium irregulare, Pythium sylvaticum and Pythium ultimum;diseases caused by Peronosporales such as Peronospora destructor, Peronospora parasitica,Plasmopara viticola, Plasmopara halstedii, Pseudoperonospora cubensis, Albugo candida,Sclerophthora macrospora and Bremia lactucae; and others such as Aphanomyces cochlioides,Labyrinthula zosterae, Peronosclerospora sorghi and Sclerospora graminicola.Ascomycetes, including blotch, spot, blast or blight diseases and / or rots for example those caused byPleosporales such as Stemphylium solani, Stagonospora tainanensis, Spilocaea oleaginea,Setosphaeria turcica, Pyrenochaeta lycoperisici, Pleospora herbarum, Phoma destructiva,Phaeosphaeria herpotrichoides, Phaeocryptocus gaeumannii, Ophiosphaerella graminicola,Ophiobolus graminis, Leptosphaeria maculans, Hendersonia creberrima, Helminthosporiumtriticirepentis, Setosphaeria turcica, Drechslera glycines, Didymella bryoniae, Cycloconium oleagineum,Corynespora cassiicola, Cochliobolus sativus, Bipolaris cactivora, Venturia inaequalis, Pyrenophorateres, Pyrenophora tritici-repentis, Alternaria alternata, Alternaria brassicicola, Alternaria solani andAlternaria tomatophila, Capnodiales such as Septoria tritici, Septoria nodorum, Septoria glycines,Cercospora arachidicola, Cercospora sojina, Cercospora zeae-maydis, Cercosporella capsellae andCercosporella herpotrichoides, Cladosporium carpophilum, Cladosporium effusum, Passalora fulva,Cladosporium oxysporum, Dothistroma septosporum, Isariopsis clavispora, Mycosphaerella fijiensis,Mycosphaerella graminicola, Mycovellosiella koepkeii, Phaeoisariopsis bataticola, Pseudocercosporavitis, Pseudocercosporella herpotrichoides, Ramularia beticola, Ramularia collo-cygni, Magnaporthalessuch as Gaeumannomyces graminis, Magnaporthe grisea, Pyricularia oryzae, Diaporthales such asAnisogramma anomala, Apiognomonia errabunda, Cytospora platani, Diaporthe phaseolorum, Disculadestructiva, Gnomonia fructicola, Greeneria uvicola, Melanconium juglandinum, Phomopsis viticola,Sirococcus clavigignenti-juglandacearum, Tubakia dryina, Dicarpella spp., Valsa ceratosperma, andothers such as Actinothyrium graminis, Ascochyta pisi, Aspergillus flavus, Aspergillus fumigatus,Aspergillus nidulans, Asperisporium caricae, Blumeriella jaapii, Candida spp., Capnodium ramosum,Cephaloascus spp., Cephalosporium gramineum, Ceratocystis paradoxa, Chaetomium spp.,Hymenoscyphus pseudoalbidus, Coccidioides spp., Cylindrosporium padi, Diplocarpon malae,Drepanopeziza campestris, Elsinoe ampelina, Epicoccum nigrum, Epidermophyton spp., Eutypa lata, Geotrichum candidum, Gibellina cerealis, Gloeocercospora sorghi, Gloeodes pomigena, Gloeosporiumperennans; Gloeotinia temulenta, Griphospaeria corticola, Kabatiella lini, Leptographium microsporum,Leptosphaerulinia crassiasca, Lophodermium seditiosum, Marssonina graminicola, Microdochiumnivale, Monilinia fructicola, Monographella albescens, Monosporascus cannonballus, Naemacyclusspp., Ophiostoma novo-ulmi, Paracoccidioides brasiliensis, Penicillium expansum, Pestalotia rhododendri, Petriellidium spp., Pezicula spp., Phialophora gregata, Phyllachora pomigena, Phymatotrichum omnivora, Physalospora abdita, Plectosporium tabacinum, Polyscytalum pustulans, Pseudopeziza medicaginis, Pyrenopeziza brassicae, Ramulispora sorghi, Rhabdocline pseudotsugae,Rhynchosporium secalis, Sacrocladium oryzae, Scedosporium spp., Schizothyrium pomi, Sclerotiniasclerotiorum, Sclerotinia minor; Sclerotium spp., Typhula ishikariensis, Seimatosporium mariae,Lepteutypa cupressi, Septocyta ruborum, Sphaceloma perseae, Sporonema phacidioides, Stigmina palmivora, Tapesia yallundae, Taphrina bullata, Thielviopsis basicola, Trichoseptoria fructigena, Zygophiala jamaicensis; powdery mildew diseases for example those caused by Erysiphales such as Blumeria graminis, Erysiphe polygoni, Uncinula necator, Sphaerotheca fuligena, Podosphaeraleucotricha, Podospaera macularis Golovinomyces cichoracearum, Leveillula taurica, Microsphaeradiffusa, Oidiopsis gossypii, Phyllactinia guttata and Oidium arachidis; molds for example those causedby Botryosphaeriales such as Dothiorella aromatica, Diplodia seriata, Guignardia bidwellii, Botrytiscinerea, Botryotinia allii, Botryotinia fabae, Fusicoccum amygdali, Lasiodiplodia theobromae, Macrophoma theicola, Macrophomina phaseolina, Phyllosticta cucurbitacearum; anthracnoses for example those caused by Glommerelales such as Colletotrichum gloeosporioides, Colletotrichumlagenarium, Colletotrichum gossypii, Glomerella cingulata, and Colletotrichum graminicola; and wilts orblights for example those caused by Hypocreales such as Acremonium strictum, Claviceps purpurea,Fusarium culmorum, Fusarium graminearum, Fusarium virguliforme, Fusarium oxysporum, Fusariumsubglutinans, Fusarium oxysporum f.sp. cubense, Gerlachia nivale, Gibberella fujikuroi, Gibberellazeae, Gliocladium spp., Myrothecium verrucaria, Nectria ramulariae, Trichoderma viride, Trichothecium roseum, and Verticillium theobromae. Basidiomycetes, including smuts for example those caused by Ustilaginales such as Ustilaginoidea virens, Ustilago nuda, Ustilago tritici, Ustilago zeae, rusts for example those caused by Pucciniales suchas Cerotelium fici, Chrysomyxa arctostaphyli, Coleosporium ipomoeae, Hemileia vastatrix, Pucciniaarachidis, Puccinia cacabata, Puccinia graminis, Puccinia recondita, Puccinia sorghi, Puccinia hordei,Puccinia striiformis f.sp. Hordei, Puccinia striiformis f.sp. Secalis, Pucciniastrum coryli, or Uredinalessuch as Cronartium ribicola, Gymnosporangium juniperi-viginianae, Melampsora medusae, Phakopsora pachyrhizi, Phragmidium mucronatum, Physopella ampelosidis, Tranzschelia discolor and Uromyces viciae-fabae; and other rots and diseases such as those caused by Cryptococcus spp., Exobasidium vexans, Marasmiellus inoderma, Mycena spp., Sphacelotheca reiliana, Typhula ishikariensis, Urocystisagropyri, Itersonilia perplexans, Corticium invisum, Laetisaria fuciformis, Waitea circinata, Rhizoctoniasolani, Thanetephorus cucurmeris, Entyloma dahliae, Entylomella microspora, Neovossia moliniae andTilletia caries. Blastocladiomycetes, such as Physoderma maydis.Mucoromycetes, such as Choanephora cucurbitarum.; Mucor spp.; Rhizopus arrhizus.As well as diseases caused by other species and genera closely related to those listed above. In addition to their fungicidal activity, the compounds and compositions comprising compounds offormula (I) as defined in the present invention may also have activity against bacteria such as Erwiniaamylovora, Erwinia caratovora, Xanthomonas campestris, Pseudomonas syringae, Strptomycesscabies and other related species as well as certain protozoa. Within the scope of the present invention, target crops and / or useful plants to be protected typically comprise perennial and annual crops, such as berry plants for example blackberries, blueberries, cranberries, raspberries and strawberries; cereals for example barley, maize (corn), millet, oats, rice, rye, sorghum triticale and wheat; fibre plants for example cotton, flax, hemp, jute and sisal; field crops for example sugar and fodder beet, coffee, hops, mustard, oilseed rape (canola), poppy, sugar cane, sunflower, tea and tobacco; fruit trees for example apple, apricot, avocado, banana, cherry, citrus, nectarine, peach, pear and plum; grasses for example Bermuda grass, bluegrass, bentgrass, centipede grass, fescue, ryegrass, St. Augustine grass and Zoysia grass; herbs such as basil, borage, chives, coriander, lavender, lovage, mint, oregano, parsley, rosemary, sage and thyme; legumes for example beans, lentils, peas and soya beans; nuts for example almond, cashew, ground nut, hazelnut, peanut,pecan, pistachio and walnut; palms for example oil palm; ornamentals for example flowers, shrubs andtrees; other trees, for example cacao, coconut, olive and rubber; vegetables for example asparagus, aubergine, broccoli, cabbage, carrot, cucumber, garlic, lettuce, marrow, melon, okra, onion, pepper,potato, pumpkin, rhubarb, spinach and tomato; and vines for example grapes.The useful plants and / or target crops in accordance with the invention include conventional as well as genetically enhanced or engineered varieties such as, for example, insect resistant (e.g. Bt. and VIPvarieties) as well as disease resistant, herbicide tolerant (e.g. glyphosate- and glufosinate-resistantmaize varieties commercially available under the trade names RoundupReady® and LibertyLink®) and nematode tolerant varieties. By way of example, suitable genetically enhanced or engineered crop varieties include the Stoneville 5599BR cotton and Stoneville 4892BR cotton varieties. The term "useful plants" and / or “target crops” is to be understood as including also useful plants that have been rendered tolerant to herbicides like bromoxynil or classes of herbicides (such as, for example, HPPD inhibitors, ALS inhibitors, for example primisulfuron, prosulfuron and trifloxysulfuron, EPSPS (5- enol-pyrovyl-shikimate-3-phosphate-synthase) inhibitors, GS (glutamine synthetase) inhibitors or PPO (protoporphyrinogen-oxidase) inhibitors) as a result of conventional methods of breeding or genetic engineering. An example of a crop that has been rendered tolerant to imidazolinones, e.g. imazamox, by conventional methods of breeding (mutagenesis) is Clearfield® summer rape (Canola). Examples of crops that have been rendered tolerant to herbicides or classes of herbicides by genetic engineeringmethods include glyphosate- and glufosinate-resistant maize varieties commercially available under thetrade names RoundupReady®, Herculex I® and LibertyLink®. The term "useful plants" and / or “target crops” is to be understood as including those which naturally are or have been rendered resistant to harmful insects. This includes plants transformed by the use of recombinant DNA techniques, for example, to be capable of synthesising one or more selectively acting toxins, such as are known, for example, from toxin-producing bacteria. Examples of toxins which can be expressed include ^-endotoxins, vegetative insecticidal proteins (Vip), insecticidal proteins of bacteria colonising nematodes, and toxins produced by scorpions, arachnids, wasps and fungi. Anexample of a crop that has been modified to express the Bacillus thuringiensis toxin is the Bt maizeKnockOut^ (Syngenta Seeds). An example of a crop comprising more than one gene that codes forinsecticidal resistance and thus expresses more than one toxin is VipCot^ (Syngenta Seeds). Crops orseed material thereof can also be resistant to multiple types of pests (so-called stacked transgenic events when created by genetic modification). For example, a plant can have the ability to express aninsecticidal protein while at the same time being herbicide tolerant, for example Herculex I^ (DowAgroSciences, Pioneer Hi-Bred International). The term "useful plants" and / or “target crops” is to be understood as including also useful plants which have been so transformed by the use of recombinant DNA techniques that they are capable of synthesising antipathogenic substances having a selective action, such as, for example, the so-called "pathogenesis-related proteins" (PRPs, see e.g. EP-A-0392225). Examples of such antipathogenic substances and transgenic plants capable of synthesising such antipathogenic substances are known,for example, from EP-A-0392225, WO 95 / 33818, and EP-A-0353191. The methods of producing suchtransgenic plants are generally known to the person skilled in the art and are described, for example, in the publications mentioned above. Toxins that can be expressed by transgenic plants include, for example, insecticidal proteins from Bacillus cereus or Bacillus popilliae; or insecticidal proteins from Bacillus thuringiensis, such as ^- endotoxins, e.g. Cry1Ab, Cry1Ac, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1 or Cry9C, or vegetative insecticidal proteins (Vip), e.g. Vip1, Vip2, Vip3 or Vip3A; or insecticidal proteins of bacteria colonising nematodes, for example Photorhabdus spp. or Xenorhabdus spp., such as Photorhabdus luminescens, Xenorhabdus nematophilus; toxins produced by animals, such as scorpion toxins, arachnid toxins, wasp toxins and other insect-specific neurotoxins; toxins produced by fungi, such as Streptomycetes toxins, plant lectins, such as pea lectins, barley lectins or snowdrop lectins; agglutinins; proteinase inhibitors, such as trypsin inhibitors, serine protease inhibitors, patatin, cystatin, papain inhibitors; ribosome- inactivating proteins (RIP), such as ricin, maize-RIP, abrin, luffin, saporin or bryodin; steroid metabolism enzymes, such as 3-hydroxysteroidoxidase, ecdysteroid-UDP-glycosyl-transferase, cholesterol oxidases, ecdysone inhibitors, HMG-COA-reductase, ion channel blockers, such as blockers of sodium or calcium channels, juvenile hormone esterase, diuretic hormone receptors, stilbene synthase, bibenzyl synthase, chitinases and glucanases. Further, in the context of the present invention there are to be understood by ^-endotoxins, for example Cry1Ab, Cry1Ac, Cry1F, Cry1Fa2, Cry2Ab, Cry3A, Cry3Bb1 or Cry9C, or vegetative insecticidal proteins (Vip), for example Vip1, Vip2, Vip3 or Vip3A, expressly also hybrid toxins, truncated toxins and modified toxins. Hybrid toxins are produced recombinantly by a new combination of different domains of those proteins (see, for example, WO 02 / 15701). Truncated toxins, for example a truncated Cry1Ab, are known. In the case of modified toxins, one or more amino acids of the naturally occurring toxin are replaced. In such amino acid replacements, preferably non-naturally present protease recognition sequences are inserted into the toxin, such as, for example, in the case of Cry3A055, a cathepsin-G- recognition sequence is inserted into a Cry3A toxin (see WO03 / 018810). More examples of such toxins or transgenic plants capable of synthesising such toxins are disclosed, for example, in EP-A-0374753, WO93 / 07278, WO95 / 34656, EP-A-0427529, EP-A-451878 and WO03 / 052073. The processes for the preparation of such transgenic plants are generally known to the person skilled in the art and are described, for example, in the publications mentioned above. CryI-type deoxyribonucleic acids and their preparation are known, for example, from WO 95 / 34656, EP-A-0367 474, EP-A-0401979 and WO 90 / 13651. The toxin contained in the transgenic plants imparts to the plants tolerance to harmful insects. Such insects can occur in any taxonomic group of insects, but are especially commonly found in the beetles (Coleoptera), two-winged insects (Diptera) and butterflies (Lepidoptera). Transgenic plants containing one or more genes that code for an insecticidal resistance and express one or more toxins are known and some of them are commercially available. Examples of such plantsare: YieldGard^ (maize variety that expresses a Cry1Ab toxin); YieldGard Rootworm^ (maize varietythat expresses a Cry3Bb1 toxin); YieldGard Plus^ (maize variety that expresses a Cry1Ab and aCry3Bb1 toxin); Starlink^ (maize variety that expresses a Cry9C toxin); Herculex I^ (maize variety thatexpresses a Cry1Fa2 toxin and the enzyme phosphinothricine N-acetyltransferase (PAT) to achievetolerance to the herbicide glufosinate ammonium); NuCOTN 33B^ (cotton variety that expresses aCry1Ac toxin); Bollgard I^ (cotton variety that expresses a Cry1Ac toxin); Bollgard II® (cotton varietythat expresses a Cry1Ac and a Cry2Ab toxin); VipCot^ (cotton variety that expresses a Vip3A and aCry1Ab toxin); NewLeaf^ (potato variety that expresses a Cry3A toxin); NatureGard^, Agrisure® GTAdvantage (GA21 glyphosate-tolerant trait), Agrisure® CB Advantage (Bt11 corn borer (CB) trait) and Protecta^. Further examples of such transgenic crops are:1. Bt11 Maize from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790 St. Sauveur, France,registration number C / FR / 96 / 05 / 10. Genetically modified Zea mays which has been rendered resistantto attack by the European corn borer (Ostrinia nubilalis and Sesamia nonagrioides) by transgenicexpression of a truncated Cry1Ab toxin. Bt11 maize also transgenically expresses the enzyme PAT to achieve tolerance to the herbicide glufosinate ammonium.2. Bt176 Maize from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790 St. Sauveur, France,registration number C / FR / 96 / 05 / 10. Genetically modified Zea mays which has been rendered resistantto attack by the European corn borer (Ostrinia nubilalis and Sesamia nonagrioides) by transgenicexpression of a Cry1Ab toxin. Bt176 maize also transgenically expresses the enzyme PAT to achieve tolerance to the herbicide glufosinate ammonium.3. MIR604 Maize from Syngenta Seeds SAS, Chemin de l'Hobit 27, F-31 790 St. Sauveur, France,registration number C / FR / 96 / 05 / 10. Maize which has been rendered insect-resistant by transgenicexpression of a modified Cry3A toxin. This toxin is Cry3A055 modified by insertion of a cathepsin-G-protease recognition sequence. The preparation of such transgenic maize plants is described in WO 03 / 018810.4. MON 863 Maize from Monsanto Europe S.A. 270-272 Avenue de Tervuren, B-1150 Brussels,Belgium, registration number C / DE / 02 / 9. MON 863 expresses a Cry3Bb1 toxin and has resistance to certain Coleoptera insects.5. IPC 531 Cotton from Monsanto Europe S.A. 270-272 Avenue de Tervuren, B-1150 Brussels,Belgium, registration number C / ES / 96 / 02.6. 1507 Maize from Pioneer Overseas Corporation, Avenue Tedesco, 7 B-1160 Brussels, Belgium,registration number C / NL / 00 / 10. Genetically modified maize for the expression of the protein Cry1F for achieving resistance to certain Lepidoptera insects and of the PAT protein for achieving tolerance to the herbicide glufosinate ammonium.7. NK603 × MON 810 Maize from Monsanto Europe S.A. 270-272 Avenue de Tervuren, B-1150Brussels, Belgium, registration number C / GB / 02 / M3 / 03. Consists of conventionally bred hybrid maize varieties by crossing the genetically modified varieties NK603 and MON 810. NK603 × MON 810 Maize transgenically expresses the protein CP4 EPSPS, obtained from Agrobacterium sp. strain CP4, which imparts tolerance to the herbicide Roundup® (contains glyphosate), and also a Cry1Ab toxin obtainedfrom Bacillus thuringiensis subsp. kurstaki which brings about tolerance to certain Lepidoptera, includethe European corn borer. The term “locus” as used herein means fields in or on which plants are growing, or where seeds of cultivated plants are sown, or where seed will be placed into the soil. It includes soil, seeds, and seedlings, as well as established vegetation. The term “plants” refers to all physical parts of a plant, including seeds, seedlings, saplings, roots, tubers, stems, stalks, foliage, and fruits. The term “plant propagation material” is understood to denote generative parts of the plant, such as seeds, which can be used for the multiplication of the latter, and vegetative material, such as cuttings or tubers, for example potatoes. There may be mentioned for example seeds (in the strict sense), roots, fruits, tubers, bulbs, rhizomes and parts of plants. Germinated plants and young plants which are to be transplanted after germination or after emergence from the soil, may also be mentioned. These youngplants may be protected before transplantation by a total or partial treatment by immersion. Preferably“plant propagation material” is understood to denote seeds. Pesticidal agents referred to herein using their common name are known, for example, from "The Pesticide Manual", 19th Ed., British Crop Protection Council 2021.The compounds of formula (I) as defined in the present invention may be used in unmodified form or,preferably, together with the adjuvants conventionally employed in the art of formulation. To this end they may be conveniently formulated in known manner to emulsifiable concentrates, coatable pastes, directly sprayable or dilutable solutions or suspensions, dilute emulsions, wettable powders, soluble powders, dusts, granulates, and also encapsulations e.g. in polymeric substances. As with the type of the compositions, the methods of application, such as spraying, atomising, dusting, scattering, coating or pouring, are chosen in accordance with the intended objectives and the prevailing circumstances. The compositions may also contain further adjuvants such as stabilizers, antifoams, viscosity regulators, binders or tackifiers as well as fertilizers, micronutrient donors or other formulations for obtaining special effects.Suitable carriers and / or adjuvants, e.g. for agricultural use, can be solid or liquid and are substancesuseful in formulation technology, e.g. natural or regenerated mineral substances, solvents, dispersants, wetting agents, tackifiers, thickeners, binders or fertilizers. Such carriers are for example described in WO 97 / 33890. Suspension concentrates are aqueous formulations in which finely divided solid particles of the active compound are suspended. Such formulations include anti-settling agents and dispersing agents and may further include a wetting agent to enhance activity as well an anti-foam and a crystal growth inhibitor. In use, these concentrates are diluted in water and normally applied as a spray to the area to be treated. The amount of active ingredient may range from 0.5% to 95% of the concentrate. Wettable powders are in the form of finely divided particles which disperse readily in water or other liquid carriers. The particles contain the active ingredient retained in a solid matrix. Typical solid matrices include fuller’s earth, kaolin clays, silicas and other readily wet organic or inorganic solids. Wettablepowders normally contain from 5% to 95% of the active ingredient plus a small amount of wetting,dispersing or emulsifying agent. Emulsifiable concentrates are homogeneous liquid compositions dispersible in water or other liquid and may consist entirely of the active compound with a liquid or solid emulsifying agent, or may also contain a liquid carrier, such as xylene, heavy aromatic naphthas, isophorone and other non-volatile organic solvents. In use, these concentrates are dispersed in water or other liquid and normally applied as a spray to the area to be treated. The amount of active ingredient may range from 0.5% to 95% of the concentrate. Granular formulations include both extrudates and relatively coarse particles and are usually applied without dilution to the area in which treatment is required. Typical carriers for granular formulations include sand, fuller’s earth, attapulgite clay, bentonite clays, montmorillonite clay, vermiculite, perlite, calcium carbonate, brick, pumice, pyrophyllite, kaolin, dolomite, plaster, wood flour, ground corn cobs, ground peanut hulls, sugars, sodium chloride, sodium sulphate, sodium silicate, sodium borate, magnesia, mica, iron oxide, zinc oxide, titanium oxide, antimony oxide, cryolite, gypsum, diatomaceous earth, calcium sulphate and other organic or inorganic materials which absorb or which can be coated with the active compound. Granular formulations normally contain 5% to 25% of active ingredients which may include surface-active agents such as heavy aromatic naphthas, kerosene and other petroleum fractions, or vegetable oils; and / or stickers such as dextrins, glue or synthetic resins. Dusts are free-flowing admixtures of the active ingredient with finely divided solids such as talc, clays, flours and other organic and inorganic solids which act as dispersants and carriers. Microcapsules are typically droplets or granules of the active ingredient enclosed in an inert porous shell which allows escape of the enclosed material to the surroundings at controlled rates. Encapsulated droplets are typically 1 to 50 microns in diameter. The enclosed liquid typically constitutes 50 to 95% of the weight of the capsule and may include solvent in addition to the active compound. Encapsulated granules are generally porous granules with porous membranes sealing the granule pore openings, retaining the active species in liquid form inside the granule pores. Granules typically range from 1 millimetre to 1 centimetre and preferably 1 to 2 millimetres in diameter. Granules are formed by extrusion, agglomeration or prilling, or are naturally occurring. Examples of such materials are vermiculite, sintered clay, kaolin, attapulgite clay, sawdust and granular carbon. Shell or membrane materials include natural and synthetic rubbers, cellulosic materials, styrene-butadiene copolymers, polyacrylonitriles, polyacrylates, polyesters, polyamides, polyureas, polyurethanes and starch xanthates. Other useful formulations for agrochemical applications include simple solutions of the active ingredient in a solvent in which it is completely soluble at the desired concentration, such as acetone, alkylated naphthalenes, xylene and other organic solvents. Pressurised sprayers, wherein the active ingredient is dispersed in finely-divided form as a result of vaporisation of a low boiling dispersant solvent carrier, may also be used.Suitable agricultural adjuvants and / or carriers that are useful in formulating the compositions of theinvention in the formulation types described above are well known to those skilled in the art. Liquid carriers that can be employed include, for example, water, toluene, xylene, petroleum naphtha, crop oil, acetone, methyl ethyl ketone, cyclohexanone, acetic anhydride, acetonitrile, acetophenone, amyl acetate, 2-butanone, chlorobenzene, cyclohexane, cyclohexanol, alkyl acetates, diacetonalcohol, 1,2-dichloropropane, diethanolamine, p-diethylbenzene, diethylene glycol, diethylene glycol abietate, diethylene glycol butyl ether, diethylene glycol ethyl ether, diethylene glycol methyl ether, N,N-dimethyl formamide, dimethyl sulfoxide, 1,4-dioxane, dipropylene glycol, dipropylene glycol methyl ether, dipropylene glycol dibenzoate, diproxitol, alkyl pyrrolidinone, ethyl acetate, 2-ethyl hexanol, ethylene carbonate, 1,1,1-trichloroethane, 2-heptanone, alpha pinene, d-limonene, ethylene glycol, ethylene glycol butyl ether, ethylene glycol methyl ether, gamma-butyrolactone, glycerol, glycerol diacetate, glycerol monoacetate, glycerol triacetate, hexadecane, hexylene glycol, isoamyl acetate, isobornyl acetate, isooctane, isophorone, isopropyl benzene, isopropyl myristate, lactic acid, laurylamine, mesityl oxide, methoxy-propanol, methyl isoamyl ketone, methyl isobutyl ketone, methyl laurate, methyl octanoate, methyl oleate, methylene chloride, m-xylene, n-hexane, n-octylamine, octadecanoic acid,octyl amine acetate, oleic acid, oleylamine, o-xylene, phenol, polyethylene glycol (PEG400), propionicacid, propylene glycol, propylene glycol monomethyl ether, p-xylene, toluene, triethyl phosphate, triethylene glycol, xylene sulfonic acid, paraffin, mineral oil, trichloroethylene, perchloroethylene, ethyl acetate, amyl acetate, butyl acetate, methanol, ethanol, isopropanol, and higher molecular weight alcohols such as amyl alcohol, tetrahydrofurfuryl alcohol, hexanol, octanol, etc., ethylene glycol, propylene glycol, glycerine and N-methyl-2-pyrrolidinone. Water is generally the carrier of choice for the dilution of concentrates. Suitable solid carriers include, for example, talc, titanium dioxide, pyrophyllite clay, silica, attapulgite clay, kieselguhr, chalk, diatomaxeous earth, lime, calcium carbonate, bentonite clay, fuller’s earth, cotton seed hulls, wheat flour, soybean flour, pumice, wood flour, walnut shell flour and lignin. A broad range of surface-active agents are advantageously employed in both said liquid and solid compositions, especially those designed to be diluted with carrier before application. These agents, when used, normally comprise from 0.1% to 15% by weight of the formulation. They can be anionic,cationic, non-ionic or polymeric in character and can be employed as emulsifying agents, wetting agents,suspending agents or for other purposes. Typical surface active agents include salts of alkyl sulfates, such as diethanolammonium lauryl sulphate; alkylarylsulfonate salts, such as calcium dodecylbenzenesulfonate; alkylphenol-alkylene oxide addition products, such as nonylphenol-C.sub.18 ethoxylate; alcohol-alkylene oxide addition products, such as tridecyl alcohol-C.sub. 16 ethoxylate; soaps, such as sodium stearate; alkylnaphthalenesulfonate salts, such as sodium dibutylnaphthalenesulfonate; dialkyl esters of sulfosuccinate salts, such as sodium di(2-ethylhexyl) sulfosuccinate; sorbitol esters, such as sorbitol oleate; quaternary amines, such as lauryl trimethylammonium chloride; polyethylene glycol esters of fatty acids, such as polyethylene glycol stearate; block copolymers of ethylene oxide and propylene oxide; and salts of mono and dialkyl phosphate esters. Other adjuvants commonly utilized in agricultural compositions include crystallisation inhibitors, viscosity modifiers, suspending agents, spray droplet modifiers, pigments, antioxidants, foaming agents, anti- foaming agents, light-blocking agents, compatibilizing agents, antifoam agents, sequestering agents, neutralising agents and buffers, corrosion inhibitors, dyes, odorants, spreading agents, penetration aids, micronutrients, emollients, lubricants and sticking agents. In addition, further, other biocidally active ingredients or compositions may be combined with the compositions of the invention and used in the methods of the invention and applied simultaneously or sequentially with the compositions of the invention. When applied simultaneously, these further active ingredients may be formulated together with the compositions of the invention or mixed in, for example,the spray tank. These further biocidally active ingredients may be fungicides, herbicides, insecticides,bactericides, acaricides, nematicides, plant growth regulators, and / or biologicals.In addition, the compositions of the invention may also be applied with one or more systemically acquired resistance inducers (“SAR” inducer). SAR inducers are known and described in, for example, UnitedStates Patent No. US 6,919,298 and include, for example, salicylates and the commercial SAR induceracibenzolar-S-methyl.The compounds of formula (I) as defined in the present invention are normally used in the form ofcompositions and can be applied to the crop area or plant to be treated, simultaneously or in succession with further compounds. These further compounds can be e.g. fertilizers or micronutrient donors or other preparations, which influence the growth of plants. They can also be selective herbicides or non- selective herbicides as well as insecticides, fungicides, bactericides, nematicides, molluscicides or mixtures of several of these preparations, if desired together with further carriers, surfactants or application promoting adjuvants customarily employed in the art of formulation.The compounds of formula (I) as defined in the present invention may be used in the form of (fungicidal)compositions for controlling or protecting against phytopathogenic microorganisms, comprising as activeingredient at least one compound of formula (I) as defined in the present invention or of at least onepreferred individual compound as above-defined, in free form or in agrochemically usable salt form, and at least one of the above-mentioned adjuvants. The invention therefore provides a composition, preferably a fungicidal composition, comprising at leastone compound of formula (I) as defined in the present invention, an agriculturally acceptable carrier andoptionally an adjuvant. An agricultural acceptable carrier is for example a carrier that is suitable for agricultural use. Agricultural carriers are well known in the art. Preferably said composition maycomprise at least one or more pesticidally active compounds, for example an additional fungicidal activeingredient in addition to the compound of formula (I) as defined in the present invention. A further aspect of invention is related to a method of controlling or preventing an infestation of plants, e.g. useful plants such as crop plants, propagation material thereof, e.g. seeds, harvested crops, e.g. harvested food crops, or of non-living materials by phytopathogenic or spoilage microorganisms or organisms potentially harmful to man, especially fungal organisms, which comprises the application ofa compound of formula (I) as defined in the present invention or of a preferred individual compound asabove-defined as active ingredient to the plants, to parts of the plants or to the locus thereof, to the propagation material thereof, or to any part of the non-living materials. Controlling or preventing means reducing infestation by insects or by phytopathogenic or spoilage microorganisms or organisms potentially harmful to man, especially fungal organisms, to such a level that an improvement is demonstrated. A preferred method of controlling or preventing an infestation of crop plants by phytopathogenic microorganisms, especially fungal organisms, which comprises the application of a compound of formula (I) as defined in the present invention, or an agrochemical composition which contains at least one of said compounds, is foliar application. The frequency of application and the rate of application will depend on the risk of infestation by the corresponding pathogen or insect. However, the compounds of formula(I) as defined in the present invention can also penetrate the plant through the roots via the soil (systemicaction) by drenching the locus of the plant with a liquid formulation, or by applying the compounds insolid form to the soil, e.g. in granular form (soil application). In crops of water rice such granulates canbe applied to the flooded rice field. The compounds of formula (I) as defined in any the present inventionmay also be applied to seeds (coating) by impregnating the seeds or tubers either with a liquid formulation of the fungicide or coating them with a solid formulation. A formulation, e.g. a composition containing the compound of formula (I) as defined in the present invention, and, if desired, a solid or liquid adjuvant or monomers for encapsulating the compound of formula (I) as defined in the present invention, may be prepared in a known manner, typically by intimately mixing and / or grinding the compound with extenders, for example solvents, solid carriers and, optionally, surface active compounds (surfactants). The application methods for the compositions, that is the methods of controlling pathogens of the abovementioned type, such as spraying, atomizing, dusting, brushing on, dressing, scattering or pouring- which are to be selected to suit the intended aims of the prevailing circumstances - and the use of thecompositions for controlling pathogens of the abovementioned type are other subjects of the invention. Typical rates of concentration are between 0.1 and 1000 ppm, preferably between 0.1 and 500 ppm, of active ingredient. The rate of application per hectare is preferably 1g to 2000 g of active ingredient per hectare, more preferably 10 to 1000 g / ha, most preferably 10 to 600 g / ha. When used as seed drenching agent, convenient dosages are from 10mg to 1g of active substance per kg of seeds. When the combinations of the present invention are used for treating seed, rates of 0.001 to 50 g of a compound of formula (I) per kg of seed, preferably from 0.01 to 10g per kg of seed are generally sufficient. Suitably, a composition comprising a compound of formula (I) as defined in the present inventionaccording to the present invention is applied either preventative, meaning prior to disease developmentor curative, meaning after disease development. The compositions of the invention may be employed in any conventional form, for example in the form of a twin pack, a powder for dry seed treatment (DS), an emulsion for seed treatment (ES), a flowable concentrate for seed treatment (FS), a solution for seed treatment (LS), a water dispersible powder for seed treatment (WS), a capsule suspension for seed treatment (CF), a gel for seed treatment (GF), an emulsion concentrate (EC), a suspension concentrate (SC), a suspo-emulsion (SE), a capsule suspension (CS), a water dispersible granule (WG), an emulsifiable granule (EG), an emulsion, water in oil (EO), an emulsion, oil in water (EW), a micro-emulsion (ME), an oil dispersion (OD), an oil miscible flowable (OF), an oil miscible liquid (OL), a soluble concentrate (SL), an ultra-low volume suspension (SU), an ultra-low volume liquid (UL), a technical concentrate (TK), a dispersible concentrate (DC), a wettable powder (WP) or any technically feasible formulation in combination with agriculturally acceptable adjuvants. Such compositions may be produced in conventional manner, e.g. by mixing the active ingredients with appropriate formulation inerts (diluents, solvents, fillers and optionally other formulating ingredients such as surfactants, biocides, anti-freeze, stickers, thickeners and compounds that provide adjuvancy effects). Also conventional slow release formulations may be employed where long lasting efficacy is intended. Particularly formulations to be applied in spraying forms, such as water dispersible concentrates (e.g. EC, SC, DC, OD, SE, EW, EO and the like), wettable powders and granules, may contain surfactants such as wetting and dispersing agents and other compounds that provide adjuvancy effects, e.g. the condensation product of formaldehyde with naphthalene sulphonate, an alkylarylsulphonate, a lignin sulphonate, a fatty alkyl sulphate, and ethoxylated alkylphenol and an ethoxylated fatty alcohol. A seed dressing formulation is applied in a manner known per se to the seeds employing the combination of the invention and a diluent in suitable seed dressing formulation form, e.g. as an aqueoussuspension or in a dry powder form having good adherence to the seeds. Such seed dressingformulations are known in the art. Seed dressing formulations may contain the single active ingredients or the combination of active ingredients in encapsulated form, e.g. as slow release capsules or microcapsules. In general, the formulations include from 0.01 to 90% by weight of active agent, from 0 to 20% agriculturally acceptable surfactant and 10 to 99.99% solid or liquid formulation inerts and adjuvant(s), the active agent consisting of at least the compound of formula (I) as defined in the present invention together with component (B) and (C), and optionally other active agents, particularly microbiocides or conservatives or the like. Concentrated forms of compositions generally contain in between about 2 and80%, preferably between about 5 and 70% by weight of active agent. Application forms of formulationmay for example contain from 0.01 to 20% by weight, preferably from 0.01 to 5% by weight of active agent. Whereas commercial products will preferably be formulated as concentrates, the end user will normally employ diluted formulations. Whereas it is preferred to formulate commercial products as concentrates, the end user will normally use dilute formulations. EXAMPLES The Examples which follow serve to illustrate the invention. Certain compounds of the invention can be distinguished from known compounds by virtue of greater efficacy at low application rates, which can be verified by the person skilled in the art using the experimental procedures outlined in the Examples. Formulation Examples Wettable powders a) b) c)active ingredient [compound of formula (I)] 25 % 50 % 75 %sodium lignosulfonate 5 % 5 % -sodium lauryl sulfate 3 % - 5 %sodium diisobutylnaphthalenesulfonate - 6 % 10 %phenol polyethylene glycol ether - 2 % -(7-8 mol of ethylene oxide) highly dispersed silicic acid 5 % 10 % 10 % Kaolin 62 % 27 % -The active ingredient is thoroughly mixed with the adjuvants and the mixture is thoroughly ground in a suitable mill, affording wettable powders that can be diluted with water to give suspensions of the desired concentration. Powders for dry seed treatment a) b) c)active ingredient [compound of formula (I)] 25 % 50 % 75 %light mineral oil 5 % 5 % 5 %highly dispersed silicic acid 5 % 5 % -Kaolin 65 % 40 % -Talcum - 20%The active ingredient is thoroughly mixed with the adjuvants and the mixture is thoroughly ground in a suitable mill, affording powders that can be used directly for seed treatment. Emulsifiable concentrate active ingredient [compound of formula (I)] 10 %octylphenol polyethylene glycol ether 3 %(4-5 mol of ethylene oxide) calcium dodecylbenzenesulfonate 3 %castor oil polyglycol ether (35 mol of ethylene oxide) 4 %Cyclohexanone 30 %xylene mixture 50 % Emulsions of any required dilution, which can be used in plant protection, can be obtained from this concentrate by dilution with water.Dusts a) b) c)Active ingredient [compound of formula (I)] 5 % 6 % 4 %talcum 95 % - -Kaolin - 94 % -mineral filler - - 96 %Ready-for-use dusts are obtained by mixing the active ingredient with the carrier and grinding the mixture in a suitable mill. Such powders can also be used for dry dressings for seed. Extruder granules Active ingredient [compound of formula (I)] 15 %sodium lignosulfonate 2 %carboxymethylcellulose 1 %Kaolin 82 %The active ingredient is mixed and ground with the adjuvants, and the mixture is moistened with water. The mixture is extruded and then dried in a stream of air. Coated granules Active ingredient [compound of formula (I)] 8 %polyethylene glycol (mol. wt.200) 3 % Kaolin 89 % The finely ground active ingredient is uniformly applied, in a mixer, to the kaolin moistened with polyethylene glycol. Non-dusty coated granules are obtained in this manner. Suspension concentrate active ingredient [compound of formula (I)] 40 %propylene glycol 10 %nonylphenol polyethylene glycol ether (15 mol of ethylene oxide) 6 %Sodium lignosulfonate 10 %carboxymethylcellulose 1 %silicone oil (in the form of a 75 % emulsion in water) 1 %Water 32 %The finely ground active ingredient is intimately mixed with the adjuvants, giving a suspension concentrate from which suspensions of any desired dilution can be obtained by dilution with water. Using such dilutions, living plants as well as plant propagation material can be treated and protected against infestation by microorganisms, by spraying, pouring or immersion. Flowable concentrate for seed treatment active ingredient [compound of formula (I)] 40 %propylene glycol 5 %copolymer butanol PO / EO 2 %tristyrenephenole with 10-20 moles EO 2 %1,2-benzisothiazolin-3-one (in the form of a 20% solution in water) 0.5 %monoazo-pigment calcium salt 5 %Silicone oil (in the form of a 75 % emulsion in water) 0.2 %Water 45.3 %The finely ground active ingredient is intimately mixed with the adjuvants, giving a suspension concentrate from which suspensions of any desired dilution can be obtained by dilution with water. Using such dilutions, living plants as well as plant propagation material can be treated and protected against infestation by microorganisms, by spraying, pouring or immersion. Slow Release Capsule Suspension 28 parts of a combination of the compound of formula (I) are mixed with 2 parts of an aromatic solvent and 7 parts of toluene diisocyanate / polymethylene-polyphenylisocyanate-mixture (8:1). This mixture is emulsified in a mixture of 1.2 parts of polyvinylalcohol, 0.05 parts of a defoamer and 51.6 parts of water until the desired particle size is achieved. To this emulsion a mixture of 2.8 parts 1,6-diaminohexane in 5.3 parts of water is added. The mixture is agitated until the polymerization reaction is completed. The obtained capsule suspension is stabilized by adding 0.25 parts of a thickener and 3 parts of a dispersing agent. The capsule suspension formulation contains 28% of the active ingredients. The medium capsule diameter is 8-15 microns. The resulting formulation is applied to seeds as an aqueous suspension in an apparatus suitable for that purpose. Analytical Methods: Throughout this description, temperatures are given in degrees Celsius (°C) and “mp.” means melting point. LC-MS means Liquid Chromatography Mass Spectrometry and the description of the apparatus and the method is as follows: Method A: Spectra were recorded on a Mass Spectrometer from Waters Corporation (SQD, SQDII or QDA Single quadrupole mass spectrometer) equipped with an electrospray source (Polarity: positive and negative ions), Capillary: 0.8-3.00 kV, Cone: 5-30 V, Source Temperature: 120-150°C, Desolvation Temperature: 350-600°C, Cone Gas Flow: 50-150 l / h, Desolvation Gas Flow: 650-1000 l / h, Mass range: 110 to 950 Da and an Acquity UPLC from Waters Corporation: Binary pump, heated column compartment , diode- array detector and ELSD. Column: Waters UPLC HSS T3, 1.8 µm, 30 x 2.1 mm, Temp: 60 °C, DAD Wavelength range (nm): 210 to 400, Runtime: 1.5 min; Solvents: A = water + 5% MeOH + 0.05 % HCOOH, B= Acetonitrile + 0.05 % HCOOH; Flow (mL / min) 0.85, Gradient: 10% B isocratic for 0.2 min, then 10-100% B in 1.0 min, 100% B isocratic for 0.2min, 100-10% B in 0.05min, 10% B isocratic for 0.05 min. Method B: Spectra were recorded on a Mass Spectrometer from Agilent (Single quad mass spectrometer)equipped with a Multimode- Electron Spray and APCI (Polarity: positive and negative ions), Capillary:4.00 kV, Corona Current 4.0 µA, Charging Voltage, 2.00 kV, Nitrogen Gas Flow:12.0 L / min, NebulizerPressure: 40 psig, Mass range: 100 to 1000 m / z), dry gas temperature 250 °C, Vaporizer temperature200 °C and an UPLC from Agilent: quaternary pump, heated column compartment, Variable wave lengthdetector. Column: Eclipse Plus C18, 3.5 µm, 100 x 4.6 mm, column Temp: Ambient, Wavelength (nm):220 nm, Gradient: A = 0.05% TFA in water, B = 0.05% TFA in Acetonitrile. Gradient: time / %B: 0 / 5, 2 / 5,7 / 70, 10 / 95, 12 / 95, 12.1 / 5, 15 / 5; Flow rate: 1.0 mL / min. Method C: Spectra were recorded on a Mass Spectrometer from Agilent (Single quad mass spectrometer)equipped with a Multimode- Electron Spray and APCI (Polarity: positive and negative ions), Capillary:4.00 kV, Corona Current 4.0 µA, Charging Voltage, 2.00 kV, Nitrogen Gas Flow: 12.0 L / min, NebulizerPressure: 40 psig, Mass range: 100 to 1000 m / z), dry gas temperature 250 °C, Vaporizer temperature200 °C and an UPLC from Waters: quaternary pump, heated column compartment, Variable wave lengthdetector. Column: X-Bridge BEH C18, 2.5 µm (2.1 * 50 mm), column Temp: Ambient, Wavelength (nm):215 nm, Gradient: A = 0.05% TFA in water, B = 0.05% TFA in Acetonitrile. Gradient: time / %B: 0 / 5, 1 / 5,5 / 70, 7 / 95, 8.5 / 95, 8.6 / 5, 10 / 5; Flow rate: 0.6 mL / min. The below Table A gathers for compounds of formula (I):- LC-MS data, such as retention time (Rt), [M+H]+,- the type of method, and / or- melting point (mp).Table A: Compound name Structure Rt[M+H]+Metho mp (min) (measured) d (°C) 1methyl N-[5-[7-[(4-fluoro- 0.76 462 A 220 -3-methoxy-phenyl)- 222 methyl- carbamoyl]phthalazin-1- yl]-2-pyridyl]carbamate 2methyl N-[5-[7-[(4- 0.77 432 A 229 -fluorophenyl)-methyl- 231 carbamoyl]phthalazin-1- yl]-2-pyridyl]carbamateCompound name Structure Rt[M+H]+Metho mp (min) (measured) d (°C)methyl N-[5-[6-[(4-fluoro- 3.21 462 C 148 -3-methoxy-phenyl)- 152 methyl- carbamoyl]cinnolin-4-yl]- 2-pyridyl]carbamatemethyl N-[5-[6-[(4- 7.53 432 B 165 -fluorophenyl)-methyl- 170 carbamoyl]cinnolin-4-yl]- 2-pyridyl]carbamateethyl N-[5-[6-[(4- 0.98 445 Afluorophenyl)-methyl- carbamoyl]-4- isoquinolyl]-2- pyridyl]carbamatemethyl N-[5-[6-[(4- 0.83 431 Afluorophenyl)-methyl- carbamoyl]-4- isoquinolyl]-2- pyridyl]carbamatemethyl N-[5-[6-[(4-fluoro- 0.85 461 A3-methoxy-phenyl)- methyl-carbamoyl]-4- isoquinolyl]-2- pyridyl]carbamate4-(4-acetamidophenyl)- 6.45 430 C 150 -N-(4-chlorophenyl)-N- 155 methyl-isoquinoline-6- carboxamidemethyl N-[4-[6-[(4- 6.56 446 B 90 -chlorophenyl)-methyl- 95 carbamoyl]-4- isoquinolyl]phenyl]carba matemethyl N-[5-[6-[(4-fluoro- 0.91 476 A3-methoxy-phenyl)- methyl-carbamoyl]-8- methyl-cinnolin-4-yl]-2- pyridyl]carbamate Example 1: Preparation of methyl N-[5-[7-[(4-fluoro-3-methoxy-phenyl)-methyl- carbamoyl]phthalazin-1-yl]-2-pyridyl]carbamate (Compound 1) (Compound 1) Step A: Preparation of methyl 4-oxo-3H-phthalazine-6-carboxylate of 7-bromo-2H-phthalazin-1-one (CAS 152265-57-1) (0.50 g, 2.10 mmol)and triethylamine (0.39 mL, 2.70 mmol, 1.30 equiv.) in methanol (11.0 mL) flushed with argon for 5 min.Dichloro[1,3-bis(diphenylphosphino)propane]palladium(II) (CAS: 59831-02-6) (0.066 g, 0.11 mmol, 0.05equiv.) was then added and the reaction mixture was heated under carbon monoxide at 100 °C at 10bar overnight. The reaction mixture was cooled down to room temperature and concentrated underreduced pressure. The crude residue was purified over a silica gel cartridge (cyclohexane / ethyl acetate) to afford methyl 4-oxo-3H-phthalazine-6-carboxylateas a dark orange solid. LC-MS (method A): Rt 0.60 min, [M+H]+ = 205Step B: Preparation of N-(4-fluoro-3-methoxy-phenyl)-N-methyl-4-oxo-3H-phthalazine-6-carboxamide 6-carboxylate (0.20 g, 0.98 mmol) and 4-fluoro-3-methoxy-N-methyl-aniline (0.16 g, 0.98 mmol, 1.00 equiv.) in toluene (3.90 mL) was added at room temperatureunder argon trimethylaluminum solution (2 mol / L in toluene) (0.98 mL, 2.00 mmol, 2.00 equiv.). Thereaction mixture was heated at 90 °C and stirred for an additional 75 minutes. The reaction mixture was cooled down to room temperature and then 2N aqueous sodium hydroxide solution and water wasadded. The aqueous layer was extracted with ethyl acetate and the combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated under reduced pressure. The crude residue was purified over a silica gel cartridge (cyclohexane / ethyl acetate) to afford N-(4-fluoro- 3-methoxy-phenyl)-N-methyl-4-oxo-3H-phthalazine-6-carboxamide. LC-MS (method A): Rt 0.72 min, [M+H]+ = 328 Step C: Preparation of 4-chloro-N-(4-fluoro-3-methoxy-phenyl)-N-methyl-phthalazine-6-carboxamide phenyl)-N-methyl-4-oxo-3H-phthalazine-6-carboxamide (0.22 g, 0.67 mmol) in acetonitrile (5.40 mL) at room temperature was added via syringe phosphoryl trichloride (0.094 mL, 1.00 mmol, 1.00 equiv.). The reaction mixture was heated at 80 °C for 2 hours. The reaction mixture was then cooled down to room temperature and then aqueous sodium hydrogen carbonate solution was added. The aqueous layer was extracted with ethyl acetate and the combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated under reduced pressure to afford 4-chloro-N-(4-fluoro-3-methoxy-phenyl)-N-methyl-phthalazine-6-carboxamide. LC-MS (method A): Rt 0.80 min, [M+H]+ = 346Step D: Preparation of methyl N-[5-[7-[(4-fluoro-3-methoxy-phenyl)-methyl-carbamoyl]phthalazin-1-yl]- 2-pyridyl]carbamate (Compound 1) A mixture of 4-chloro-N-(4-fluoro-3-methoxy-phenyl)-N-methyl-phthalazine-6-carboxamide (0.23 g, 0.67 mmol), methyl N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]carbamate (0.19 g, 0.70 mmol, 1.00 equiv.) and potassium carbonate (0.64 g, 4.7 mmol, 7.00 equiv.) in toluene (6.70 mL), ethanol (2.30 mL) and water (1.30 mL) was flushed with argon for 5 min. Tetrakis(triphenylphosphine)palladium(0) (0.078 g, 0.067 mmol, 0.10 eq.) was then added and the reaction mixture was heated at 80 °C for 2 hours. The reaction mixture was cooled down to roomtemperature and then aqueous sodium hydrogen carbonate solution was added. The aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated under reduced pressure. The crude residue was purified overa silica gel cartridge (cyclohexane / ethyl acetate) to afford methyl N-[5-[7-[(4-fluoro-3-methoxy-phenyl)- methyl-carbamoyl]phthalazin-1-yl]-2-pyridyl]carbamate as a yellow solid. LC-MS (method A): Rt 0.76 min, m / z = [M+H]+ = 4621H NMR (400 MHz, DMSO-d6, ppm) δ = 10.49 -10.56 (m, 1 H), 9.63 - 9.67 (m, 1 H), 8.38 - 8.56 (m, 1 H), 8.11 - 8.19 (m, 1 H), 8.04 - 8.09 (m, 1 H), 7.97- 8.03 (m, 1 H), 7.73 - 7.95 (m, 2 H), 7.13 - 7.29 (m, 1 H), 6.86 - 7.07 (m, 1 H), 6.55 - 6.78 (m, 1 H), 3.73- 3.80 (m, 3 H), 3.61 - 3.67 (m, 3 H), 3.37 - 3.45 (m, 3 H)Example 2: Preparation of methyl N-[5-[6-[(4-fluoro-3-methoxy-phenyl)-methyl- carbamoyl]cinnolin-4-yl]-2-pyridyl]carbamate (Compound 3) (Compound 3) Step A: Preparation of methyl 4-amino-3-(2-trimethylsilylethynyl)benzoate 3-iodo-benzoate (10.0 g, 34.3 mmol), iodocopper (0.653 g, 3.43 mmol,0.10 equiv.) and N,N-diisopropylethylamine (18.0 mL, 103 mmol, 3.00 equiv.) in dioxane (120 mL) wasdegassed with argon for 5 min. Ethynyl(trimethyl)silane (6.74 g, 68.6 mmol, 2.00 equiv.) was then addedfollowed by bis(triphenylphosphine)palladium(II) dichloride (0.168 g, 0.240 mmol, 0.00070 equiv.) wasadded and stirred under argon atmosphere at 70 °C for 1 hour. The reaction mixture was cooled downto room temperature and concentrated under reduced pressure. The crude residue was purified over a silica gel cartridge (hexane / ethyl acetate) to afford methyl 4-amino-3-(2-trimethylsilylethynyl)benzoate.1H NMR (400 MHz, DMSO-d6, ppm) δ = 7.73 (s, 1 H), 7.60 – 7.67 (m, 1 H), 6.74 (d, 1 H), 6.12 (br s, 2H), 3.75 (s, 3 H), 0.26 (s, 9 H). Step B: Preparation of 4-oxo-1H-cinnoline-6-carboxylic acid methyl 4-amino-3-(2-trimethylsilylethynyl)benzoate (5.00 g, 20.2 mmol) in water (10.0 mL) and 6 N HCl (15.0 mL) at 0 °C was added dropwise a solution of sodium nitrite (2.79 g, 40.4 mmol,2.0 equiv.) in water (10.0 mL). The resulting mixture was stirred at 0 °C for 30 min, then allowed to warm up to room temperature, and finally heated at reflux for 3 hours. The reaction mixture was diluted with water and extracted with ethyl acetate. The aqueous layer was filtered, and the solid was washed withwater to afford 4-oxo-1H-cinnoline-6-carboxylic acid as a white solid.1H NMR (400 MHz, DMSO-d6, ppm) δ = 8.52 (s, 1 H), 8.21 – 8.28 (m, 1 H), 7.71 (s, 1 H), 7.50 – 7.57(m, 1 H). Step C: Preparation of 4-chlorocinnoline-6-carbonyl chloride 6-carboxylic acid (500 mg, 2.63 mmol) in phosphoryl trichloride (10.0 mL) was heated at reflux temperature for 3 hours. The reaction mixture was then concentrated underreduced pressure to get 4-chlorocinnoline-6-carbonyl chloride as a liquid, which was used immediatelyin the next step. Step D: Preparation of 4-chloro-N-(4-fluoro-3-methoxy-phenyl)-N-methyl-cinnoline-6-carboxamide 3-methoxy-N-methyl-aniline (0.22 g, 1.45 mmol, 1.20 equiv.) and N,N- diethylethanamine (0.99 mL, 7.28 mmol, 6.00 equiv.) in tetrahydrofuran (10.00 mL) was cooled down to 0°C and stirred at 0 °C for 1 hour. A solution of 4-chlorocinnoline-6-carbonyl chloride (0.29 g, 1.21mmol, 1.00 equiv.) in tetrahydrofuran (5.0 mL) was then added dropwise to the reaction mixture at 0 °C. The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture wasconcentrated under reduced pressure. The crude residue was purified over a silica gel cartridge (hexane / ethyl acetate) to afford 4-chloro-N-(4-fluoro-3-methoxy-phenyl)-N-methyl-cinnoline-6- carboxamideas a solid.LC-MS (method C): Rt 3.378 min, [M+H]+ = 346Step E: Preparation of methyl N-[5-[6-[(4-fluoro-3-methoxy-phenyl)-methyl-carbamoyl]cinnolin-4-yl]-2- pyridyl]carbamate (Compound 3)A mixture of 4-chloro-N-(4-fluoro-3-methoxy-phenyl)-N-methyl-cinnoline-6-carboxamide (70.00 mg, 0.18 mmol), methyl N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]carbamate (64.30 mg, 0.22 mmol, 1.25 equiv.) and cesium carbonate (118.70 mg, 0.36 mmol, 2.00 equiv.) in 1,4-dioxane / water (3:1, 10.00 mL) was flushed with argon for 10 min. Chloro(2-dicyclohexylphosphino-2′,4′,6′- triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) (CAS 1310584-14-5) (7.17 mg,0.0091 mmol, 0.05 equiv.) was then added and the reaction mixture was heated under microwave irradiation at 100 °C for 1 hour. The reaction mixture was cooled down to room temperature concentrated under reduced pressure. The crude residue was purified over a silica gel cartridge (n-hexane / ethyl acetate) to afford methyl N-[5-[6-[(4-fluoro-3-methoxy-phenyl)-methyl-carbamoyl]cinnolin-4-yl]-2- pyridyl]carbamate as a yellow solid. 1H NMR (400 MHz, DMSO-d6, ppm) δ =10.58 (s, 1 H), 9.35 (s, 1 H), 8.42 - 8.46 (d, 1 H), 8.39 (br s, 1H), 8.02 - 8.10 (m, 1 H), 7.89 - 7.95 (m, 1 H), 7.72 - 7.81 (m, 1 H), 7.20 - 7.25 (m, 1 H), 6.90 - 7.05 (m,1 H), 6.65 - 6.74 (m, 1 H), 3.78 (s, 3 H), 3.64 (s, 3 H), 3.40 (s, 3 H);LC-MS (method C): Rt 3.21 min, [M+H]+= 462 Example 3: Preparation of methyl N-[5-[6-[(4-fluorophenyl)-methyl-carbamoyl]-4-isoquinolyl]-2- pyridyl]carbamate (Compound 6) mmol), 4-fluoro- N-methyl-aniline (1.40 mL, 12.00 mmol, 1.50 equiv.) and N-ethyl-N-isopropyl-propan-2-amine (6.80 mL, 40.00 mmol, 5.00 equiv.) in N,N-dimethylacetamide (50.00 mL) was added 1-propanephosphonic anhydride (50% in ethyl acetate) (12.00 mL, 20.00 mmol, 2.50 equiv.). The reaction mixture was stirred at 50 °C for 1 hour. The reaction mixture was cooled down to room temperature, poured on ice water and extracted with ethyl acetate. The organic layer was washed with 10% aqueous lithium chloride solution. The combined organic layers were dried over magnesium sulfate, filtered, and concentrated under reduced pressure. The crude residue was purified over silica gel cartridge (cyclohexane / ethyl acetate) to afford 4-bromo-N-(4-fluorophenyl)-N-methyl-isoquinoline-6-carboxamide as a yellow solid. LC-MS (method A): Rt 0.93 min, [M+H]+= 359 Step B: Preparation of methyl N-[5-[7-[(4-fluoro-3-methoxy-phenyl)-methyl-carbamoyl]phthalazin-1-yl]- 2-pyridyl]carbamate (Compound 6)A mixture of 4-bromo-N-(4-fluorophenyl)-N-methyl-isoquinoline-6-carboxamide (0.15 g, 0.41 mmol), methyl N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2-pyridyl]carbamate (0.16 g, 0.57 mmol, 1.20 equiv.) and cesium carbonate (0.64 g, 4.7 mmol, 7.00 equiv.) in ethanol (2.46 mL) was flushed withargon for 5 min. Tetrakis(triphenylphosphine)palladium(0) (0.024 g, 0.01 mmol, 0.05 equiv.) was then added and the reaction mixture was heated at 100 °C for 2 hours. The reaction mixture was cooled down to room temperature and then aqueous 1M aqueous hydrogen chloride solution was added. The aqueous layer was extracted with dichloromethane and the combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated under reduced pressure. The crude residue was purified over a silica gel cartridge (cyclohexane / ethyl acetate) to afford methyl N-[5-[6-[(4- fluorophenyl)-methyl-carbamoyl]-4-isoquinolyl]-2-pyridyl]carbamate. LC-MS (method A): Rt 0.83 min, [M+H]+= 4311H NMR (400 MHz, CDCl3, ppm) δ = 3.47 (s, 3 H), 3.87 (s, 3 H), 6.85 - 7.01 (m, 4 H), 7.48 (br d, J =7.6 Hz, 1 H), 7.60 (s, 1 H), 7.70 (dd, J = 8.5, 1.64 Hz, 1 H), 7.95 (d, J = 8.4 Hz, 1 H), 7.97 - 8.03 (m, 1H), 8.12 (d, J = 8.4 Hz, 1 H), 8.15 - 8.20 (m, 1 H), 8.43 (s, 1 H), 9.21 (s, 1 H).Example 4: Preparation of 4-(4-acetamidophenyl)-N-(4-chlorophenyl)-N-methyl-isoquinoline-6- carboxamide (Compound 8) (Compound 8) Step A: Preparation of methyl 4-bromoisoquinoline-6-carboxylate isoquinoline-6-carboxylate (CAS 173089-82-2) (2.00 g, 10.68 mmol) in aceticacid (20.00 mL) was 1-bromopyrrolidine-2,5-dione (2.85 g, 16.02 mmol, 1.50 equiv.) at room temperature added. The reaction mixture was stirred heated to 80 °C and stirred for 16 hours. The reaction mixture was quenched with saturated aqueous sodium hydrogen carbonate solution and then extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated under reduced pressure to obtain methyl 4-bromoisoquinoline-6-carboxylate as an off white solid.1H NMR (400 MHz, CDCl3, ppm) δ = 9.22 (s, 1 H), 8.88 (s, 1 H), 8.80 (s, 1 H), 8.27 (dd, 1 H), 8.05 (dd,1 H), 4.03 (s, 3 H). Step B: Preparation of methyl 4-[4-(tert-butoxycarbonylamino)phenyl]isoquinoline-6-carboxylate 4-bromoisoquinoline-6-carboxylate (0.80 g, 2.85 mmol), [4-(tert- butoxycarbonylamino)phenyl]boronic acid (0.81 g, 3.42 mmol, 1.20 equiv.) and potassium carbonate (0.78 g, 5.71 mmol, 2.00 equiv.) in ethanol (10.00 mL), water (5.00 mL) and toluene (10.00 mL) was flushed with argon for 5 min. Tetrakis(triphenylphosphine)palladium(0) (0.066 g, 0.05 mmol, 0.02 equiv.) was then added and the reaction mixture was heated at 90 °C for 40 hours. The reaction mixture was cooled down to room temperature and diluted with water. The aqueous layer was extracted with ethyl acetate and the combined organic layers were washed with brine, dried over sodium sulfate, filtered,and concentrated under reduced pressure. The crude residue was purified over a silica gel cartridge (hexane / ethyl acetate) to afford methyl 4-[4-(tert-butoxycarbonylamino)phenyl]isoquinoline-6- carboxylate. 1H NMR (400 MHz, CDCl3, ppm) δ = 9.14 (s, 1 H), 8.41 (s, 1 H), 7.92 (d, 1 H), 7.73 (s, 1 H), 7.68 (d, 1H), 7.16 (d, 2 H), 6.88 – 6.96 (m, 4 H), 6.79 (d, 1 H), 3.49 (s, 3 H).Step C: Preparation of 4-[4-(tert-butoxycarbonylamino)phenyl]isoquinoline-6-carboxylic acid 4-[4-(tert-butoxycarbonylamino)phenyl]isoquinoline-6-carboxylate (0.21 g, 0.54 mmol) in tetrahydrofuran (10.00 mL) and methanol (10.00 mL) was sodium hydroxide (0.12 g, 3.16 mmol, 4.20 equiv.) in water (2.00 mL) added. The reaction mixture was stirred at room temperature for 16 hours. The reaction mixture was concentrated under reduced pressure, diluted with water and neutralised with aqueous 2N hydrogen chloride solution. The solid that has precipitated was filtered anddried under reduced pressure to obtain 4-[4-(tert-butoxycarbonylamino)phenyl]isoquinoline-6-carboxylicacid as an off white solid.1H NMR (400 MHz, DMSO-d6, ppm) δ = 9.61 (s, 1 H), 9.36 (s, 1 H), 8.48 (s, 2 H), 8.12 – 8.25 (m, 2 H),7.62 – 7.69 (m, 2 H), 7.41 – 7.48 (m, 2 H), 1.51 (s, 9 H).Step D: Preparation of tert-butyl N-[4-[6-[(4-chlorophenyl)-methyl-carbamoyl]-4- isoquinolyl]phenyl]carbamate phenyl]isoquinoline-6-carboxylic acid (0.20 g, 0.52 mmol) and 4-chloro-N-methyl-aniline (0.08 g, 0.62 mmol, 1.20 equiv.) in pyridine (5.00 mL) was cooled to 0 °C.Phosphoryl trichloride (0.24 mL, 2.61 mmol, 5.00 equiv.) was added at 0 °C and the reaction mixturewas stirred at 0°C for 30 minutes. The reaction mixture was diluted with water and extracted with ethyl acetate. The combined organic layers were washed with water and brine, dried over sodium sulfate,filtered, and concentrated under reduced pressure. The crude residue was purified over a silica gel cartridge (hexane / ethyl acetate) to afford tert-butyl N-[4-[6-[(4-chlorophenyl)-methyl-carbamoyl]-4- isoquinolyl]phenyl]carbamateas an off white solid. 1H NMR (400 MHz, CDCl3, ppm) δ = 1.57 (s, 9 H), 3.49 (s, 3 H), 6.77 (s, 1 H), 6.90 – 6.98 (m, 2 H),7.05 – 7.12 (m, 2 H), 7.15 – 7.21 (m, 2 H), 7.47 – 7.53 (m, 2 H), 7.62 – 7.74 (m, 2 H), 7.91 – 7.98 (m, 1H), 8.41 (s, 1 H), 9.19 (s, 1 H). Step E: Preparation of 4-(4-aminophenyl)-N-(4-chlorophenyl)-N-methyl-isoquinoline-6-carboxamide [4-[6-[(4-chlorophenyl)-methyl-carbamoyl]-4-isoquinolyl]phenyl]carbamate (100.00 mg, 1.19 mmol) in 1,4-dioxane (5.00 mL) was added 4M hydrogen chloride solution in 1,4- dioxane (0.48 mL, 1.95 mmol, 10.00 equiv.). The reaction mixture was stirred at room temperature for 16 hours and then concentrated under reduced pressure. The crude mixture was washed with 2- methoxy-2-methylpropane, filtered, and dried under reduced pressure to obtain 4-(4-aminophenyl)-N-(4-chlorophenyl)-N-methyl-isoquinoline-6-carboxamide as an off white solid.LC-MS (method B): Rt 6.24 min, [M+H]+= 388 Step F: Preparation of 4-(4-acetamidophenyl)-N-(4-chlorophenyl)-N-methyl-isoquinoline-6- carboxamide (Compound 8)A mixture of 4-(4-aminophenyl)-N-(4-chlorophenyl)-N-methyl-isoquinoline-6-carboxamide (0.10 g, 0.24mmol) in pyridine (2.00 mL) was cooled to 0 °C. Acetyl chloride (0.019 g, 0.24 mmol, 1.00 equiv.) wasadded at 0 °C. The reaction mixture was stirred at room temperature for 1 hour. Then the reactionmixture was diluted with water and extracted with ethyl acetate. The combined organic layers were washed with brine, dried over sodium sulfate, filtered, and concentrated under reduced pressure. The crude residue was purified over a silica gel cartridge (hexane / ethyl acetate) to afford 4-(4- acetamidophenyl)-N-(4-chlorophenyl)-N-methyl-isoquinoline-6-carboxamide as an off white solid. LC-MS (method C): Rt 6.45 min, m / z = 430 (M+H)+1H NMR (400 MHz, CDCl3, ppm) δ = 2.28 (s, 3 H), 3.49 (s, 3 H), 6.86 – 6.98 (m, 2 H), 7.04 – 7.13 (m,2 h), 7.26 - 7.33 (m, 2 H), 7.39 (br s, 1 H), 7.58 – 7.65 (m, 3 H), 7.70 – 7.77 (m, 1 H), 7.91 – 8.00 (m, 1H), 8.42 (s, 1 H), 9.19 (s, 1 H).Example 5: Preparation of methyl N-[5-[6-[(4-fluoro-3-methoxy-phenyl)-methyl-carbamoyl]-8- methyl-cinnolin-4-yl]-2-pyridyl]carbamate (Compound 10) (Compound 10) Step A: Preparation of methyl 4-amino-3-bromo-5-methyl-benzoate a 4-amino-3-methyl-benzoate (CAS 18595-14-7, 4.0 g, 24 mmol) in acetonitrile (61 mL) was added N-bromosuccinimide (4.3 g, 24 mmol). The resulting reaction mixture was stirred atroom temperature for 1 hour, poured into water, extracted with ethyl acetate. The combined organicphases were washed twice with water, dried over magnesium sulfate, filtered and concentrated underreduce pressure to give methyl 4-amino-3-bromo-5-methyl-benzoate as a brown oil. LC-MS (method A): Rt 0.91 min, m / z = 244 / 246 [M+H]+1H NMR (400 MHz, CDCl3, ppm) δ = 8.02 (d, J = 1.8 Hz, 1H), 7.67 - 7.74 (m, 1H), 4.49 (br s, 2H), 3.87(s, 3H), 2.24 (s, 3H). Step B: Preparation of methyl 3-acetyl-4-amino-5-methyl-benzoate3-bromo-5-methyl-benzoate (2.1 g, 8.6 mmol) in degassed 1,4-dioxane(60 mL) was added tributyl(1-ethoxyvinyl)stannane (4.4 mL, 13 mmol) and tetrakis(triphenylphosphine)-palladium(0) (0.41 g, 0.34 mmol), after which the reaction mixture was stirred heated to 100°C andstirred for 1.75h. An additional amount of tributyl(1-ethoxyvinyl)stannane (0.5 mL, 1.5 mmol) was thenadded and reaction mixture was stirred at 100°C for an additional 1.75h before it was allowed to cool down to room temperature. The reaction mixture was quenched with aq.2N HCl and it was stirred for 3 hours at room temperature before it was poured into aq. KF solution. After stirring for 1 hour at room temperature the mixture was filtered over Celite and the filter cake was washed with ethyl acetate. The phases of the mother liquid were separated, and the aqueous layer was extracted twice with ethyl acetate. The combined organic layers were washed with aq. KF solution and water, dried over magnesium sulfate and concentrated under reduce pressure. The crude residue was purified by flash chromatography (0-50% ethyl acetate in cyclohexane) to afford methyl 3-acetyl-4-amino-5-methyl- benzoate as a brown solid. LC-MS (method A): Rt 0.83 min, m / z = 208 [M+H]+1H NMR (400 MHz, CDCl3) δ ppm 8.37 - 8.43 (m, 1H) 7.85 (s, 1H) 6.20 - 7.19 (br s, 2H) 3.89 (s, 3H)2.66 (s, 3H) 2.19 (s, 3H) Step C: Preparation of methyl 4-hydroxy-8-methyl-cinnoline-6-carboxylate 3-acetyl-4-amino-5-methyl-benzoate (1.85 g, 8.93 mmol) in a mixture of aceticacid (44.6 mL) and sulfuric acid (2.68 mL) at 15°C was added dropwise a solution of sodium nitrite(0.924 g, 13.4 mmol) in water (8.9 mL). The resulting mixture was then slowly warmed to room temperature and stirred for 1.5h, then triethylamine (3.75 mL, 26.8 mmol) was added, and the reactionmixture was stirred at room temperature for an additional 22 hours before it was quenched with aqueous sat. sodium bicarbonate solution. The resulting mixture was extracted with ethyl acetate, the aq. layer was basified furthermore with aq.2N NaOH to pH 5-6 and extracted two more times with ethyl acetate. The combined organic layers were washed with water, dried over magnesium sulfate and concentrated under reduce pressure. The crude residue was triturated with acetonitrile, and the solid material wasfiltered off and dried under reduced pressure to give methyl 4-hydroxy-8-methyl-cinnoline-6-carboxylate. LC-MS (method A): Rt 0.65 min, m / z = 219 [M+H]+1H NMR (400 MHz, DMSO-d6) δ ppm 12.93 - 13.56 (br s, 1H) 8.47 (s, 1H) 8.06 (s, 1H) 7.88 (s, 1H) 3.89(s, 3H) 2.57 (s, 3H). Step D: Preparation of 4-hydroxy-8-methyl-cinnoline-6-carboxylic acid 4-hydroxy-8-methyl-cinnoline-6-carboxylate (1.0 g, 4.6 mmol) in a mixture of THF(14 mL) and water (14 mL) was added lithium hydroxide monohydrate (0.23 g, 5.5 mmol). The reactionmixture was stirred at room temperature for 4.75h after which an additional amount of lithium hydroxidemonohydrate (0.10 g, 2.4 mmol) was added. The resulting reaction mixture was stirred at roomtemperature for an additional 18 hours and the acidified with aq.2N HCl. The resulting precipitate wasfiltered off, rinsed with water and dried under reduce pressure to give 4-hydroxy-8-methyl-cinnoline-6-carboxylic acid as an orange solid. LC-MS (method A): Rt 0.37 min, m / z = 205 [M+H]+1H NMR (400 MHz, DMSO-d6) δ ppm 13.23 (s, 1H) 12.95 - 13.33 (br s, 1H) 8.46 (s, 1H) 8.06 (s, 1H)7.87 (s, 1H) 2.57 (s, 3H). Step E: Preparation of 4-chloro-N-(4-fluoro-3-methoxy-phenyl)-N,8-dimethyl-cinnoline-6-carboxamide a methoxy-N-methyl-aniline (0.052 g, 0.33 mmol) and 4-hydroxy-8-methyl- cinnoline-6-carboxylic acid (0.065 g, 0.32 mmol) in toluene (0.80 mL) was added phosphoryl trichloride(0.087 mL, 0.96 mmol) and the reaction mixture was stirred at 80°C for 40 min before it was concentratedunder reduce pressure to give 4-chloro-N-(4-fluoro-3-methoxy-phenyl)-N,8-dimethyl-cinnoline-6-carboxamide. The reaction mixture was used for the next step without further purification.LC-MS (method A): Rt 0.95 min, m / z = 360 [M+H]+Step F: Preparation of methyl N-[5-[6-[(4-fluoro-3-methoxy-phenyl)-methyl-carbamoyl]-8-methyl- cinnolin-4-yl]-2-pyridyl]carbamate (compound 10)To the concentrated reaction mixture obtained in step E under an argon atmosphere were added sodiumcarbonate (0.10 g, 0.96 mmol), methyl N-[5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2- pyridyl]carbamate (0.097 g, 0.35 mmol) and XPhos PdG2 (CAS 1310584-14-5, 0.026 g, 0.032 mmol).Then acetonitrile (2.5 mL) and water (1.3 mL) were added followed by diisopropylethylamine (0.1 mL). The resulting reaction mixture was stirred at 80°C for 18 hours, and then allowed to cool down to roomtemperature, filtered and concentrated under reduce pressure. The crude residue was purified threetimes by flash chromatography (ethyl acetate in cyclohexane, methanol in dichloromethane and acetonitrile in water) to afford methyl N-[5-[6-[(4-fluoro-3-methoxy-phenyl)-methyl-carbamoyl]-8-methyl-cinnolin-4-yl]-2-pyridyl]carbamate as a yellow solid.LC-MS (method A): Rt 0.91 min, m / z = 476 [M+H]+1H NMR (400 MHz, CDCl3) δ ppm 9.22 (s, 1H) 8.40 (s, 1H) 8.20 (d, J=8.4 Hz, 2H) 7.83 (s, 1H) 7.45 –7.56 (m, 2H) 6.91 (dd, J = 10.4, 8.9 Hz, 1H) 6.65 (br d, J = 6.18 Hz, 1H) 6.48 - 6.57 (m, 1H) 3.88 (s, 3H)3.72 (s, 3H) 3.49 (s, 3H) 3.04 (s, 3H).19F NMR (377 MHz, CDCl3) δ ppm -135.01 (s, 1F) Biological examples: The fungicidal activity of the compounds of the invention have been tested as follows: Phytophthora infestans / tomato / leaf disc preventative (late blight) Tomato leaf disks are placed on water agar in multiwell plates (24-well format) and sprayed with the formulated test compound diluted in water. The leaf disks are inoculated with a spore suspension of the fungus 1 day after application. The inoculated leaf disks are incubated at 16 °C and 75% rh under a light regime of 24 h darkness followed by 12 h light / 12 h darkness in a climate cabinet and the activity of a compound is assessed as percent disease control compared to untreated when anappropriate level of disease damage appears in untreated check leaf disks (5 - 7 days afterapplication). The following compounds gave at least 80% control of Phytophthora infestans at 200 ppm when compared to untreated control under the same conditions, which showed extensive disease development: 1, 3, 10 Plasmopara viticola / grape / leaf disc preventative (late blight) Grape vine leaf disks are placed on water agar in multiwell plates (24-well format) and sprayed with the formulated test compound diluted in water. The leaf disks are inoculated with a spore suspension of the fungus 1 day after application. The inoculated leaf disks are incubated at 19 °C and 80% rh under a light regime of 12 h light / 12 h darkness in a climate cabinet and the activity of a compound is assessed as percent disease control compared to untreated when an appropriate level of diseasedamage appears in untreated check leaf disks (6 - 8 days after application).The following compounds gave at least 80% control of Plasmopara viticola at 200 ppm when compared to untreated control under the same conditions, which showed extensive disease development: 3, 5, 6, 7, 10 Pythium ultimum / liquid culture (seedling damping off) Mycelia fragments and oospores of a newly grown liquid culture of the fungus are directly mixed into nutrient broth (PDB potato dextrose broth). After placing a (DMSO) solution of test compound into a microtiter plate (96-well format), the nutrient broth containing the fungal mycelia / spore mixture is added. The test plates are incubated at 24 °C and the inhibition of growth is determined photometrically 2-3 days after application. The following compounds gave at least 80% control of Pythium ultimum at 20 ppm when compared to untreated control under the same conditions, which showed extensive disease development: 1, 3, 5, 6, 7, 8, 9, 10

Claims

Claims 1. A compound of formula (I) (I)A1aare independently CR1or N, with the proviso that no more than one A1ais N;A1b are independently CR1 or N, with the proviso that no more than one A1b is N, preferably two A1b areCR1, and more preferably three A1b are CR1;R1are independently selected from hydrogen, hydroxy, halogen, CN, C1-6alkyl, C3-6cycloalkyl, C1- 6alkoxy-C1-6alkyl, C3-6cycloalkyl-C1-4alkyl, C1-6alkylsulfanyl. C1-6alkylsulfinyl, C1-6alkylsulfonyl, C1-6alkoxy, amino, and -NHC(O)C1-6alkyl; A2are independently CR2or N, with the proviso that no more than three A2are N, preferably no more than two A2are N, preferably no more than one A2is N, and more preferably the four A2are CR2; R2are independently selected from hydrogen, hydroxy, halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy- C1-6alkyl, C1-6alkoxy-C1-6alkoxy, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1- 6alkylsulfanyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, C1-6alkoxycarbonyl, C1-6alkylaminocarbonyl, diC1- 6alkylaminocarbonyl, and C1-6alkylcarbonyl, wherein each of the C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1- 6alkyl, C1-6alkoxy-C1-6alkoxy, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1- 6alkylsulfanyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, C1-6alkoxycarbonyl, C1-6alkylaminocarbonyl, diC1- 6alkylaminocarbonyl, and C1-6alkylcarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; A3is CR3or N; R3is selected from hydrogen, hydroxy, halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1- 6alkoxy-C1-6alkoxy, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1-6alkylsulfanyl, C1- 6alkylsulfinyl, C1-6alkylsulfonyl, amino, C1-6alkylamino, diC1-6-alkylamino, and C3-6cycloalkylamino,wherein each of the C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1-6alkoxy-C1-6alkoxy, C2-6alkenyl, C2- 6alkynyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1-6alkylsulfanyl, C1-6alkylsulfinyl, C1-6alkylsulfonyl, amino, C1-6alkylamino, diC1-6-alkylamino, and C3-6cycloalkylamino groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN; R4is selected from C1-6alkyl, C1-6alkoxy-C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, C2-6alkenyl, C2-6alkynyl, C1-6alkoxy, C1-6alkylsulfanyl-C1-6alkyl, C1-6alkylsulfinyl-C1-6alkyl, C1-6alkylsulfonyl-C1-6alkyl, C1-6alkoxycarbonyl-C1-6alkyl, C1-6alkylaminocarbonyl-C1-6alkyl, diC1-6alkylaminocarbonyl-C1-6alkyl, and CN, wherein each of the C1-6alkyl, C1-6alkoxy-C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, C2-6alkenyl, C2- 6alkynyl, C1-6alkoxy, C1-6alkylsulfanyl-C1-6alkyl, C1-6alkylsulfinyl-C1-6alkyl, C1-6alkylsulfonyl-C1-6alkyl, C1- 6alkoxycarbonyl-C1-6alkyl, C1-6alkylaminocarbonyl-C1-6alkyl and diC1-6alkylaminocarbonyl-C1-6alkyl groups is optionally substituted with one to three substituents independently selected from halogen and CN; wherein A3and R4taken together optionally form a ring, more preferably a 5-8-membered heterocycle,and more preferably a 6-membered heterocycle; andR5is selected from C1-6alkyl, C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1-6alkoxyC1-6alkyl, C1- 6alkylamino, diC1-6alkylamino, C1-6alkoxyamino, and C1-6alkylC1-6alkoxyamino, wherein each of the C1- 6alkyl, C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, C1-6alkoxyC1-6alkyl, C1-6alkylamino, diC1- 6alkylamino, C1-6alkoxyamino, and C1-6alkylC1-6alkoxyamino groups is optionally substituted with one to three substituents independently selected from halogen and CN; or a salt or N-oxide thereof.

2. The compound according to claim 1, wherein the two A1a are CR1.

3. The compound according to claim 1, wherein one of the two A1a is CR1, and the other A1a is N.

4. The compound according to any one of the preceding claims, wherein R2 are independently selectedfrom hydrogen, hydroxy, halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1-6alkoxy-C1-6alkoxy, C1-6alkoxycarbonyl, C1-6alkylaminocarbonyl, diC1-6alkylaminocarbonyl, and C1-6alkylcarbonyl, wherein each of the C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, C1-6alkoxy-C1-6alkoxy, C1-6alkoxycarbonyl, C1- 6alkylaminocarbonyl, diC1-6alkylaminocarbonyl, and C1-6alkylcarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN.

5. The compound according to any one of the preceding claims, wherein R3is selected from hydrogen, hydroxy, halogen, CN, C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, and C1-6alkoxycarbonyl, wherein each of the C1-6alkyl, C1-6alkoxy, C1-6alkoxy-C1-6alkyl, and C1-6alkoxycarbonyl groups is optionally substituted with one to three substituents independently selected from halogen, hydroxy, and CN.

6. The compound according to any one of the preceding claims, wherein four A2are CR2and A3is N.

7. The compound according to any one of the claims 1 to 6, wherein and preferably the three A2are CR2and A3is CR3.

8. The compound according to any one of the claims 1 to 6, wherein , and preferably the three A2are CR2and A3is CR3.

9. The compound according to any one of the claims 1 to 6, wherein four A2are CR2and A3is CR3, and .

10. The compound according to any one of the preceding claims, wherein R4 is selected from C1-6alkyl,C1-6alkoxy-C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, C2-6alkenyl, C2-6alkynyl, and C1-6alkoxy, wherein each of the C1-6alkyl, C1-6alkoxy-C1-6alkyl, C3-6cycloalkyl, C3-6cycloalkyl-C1-4alkyl, C2-6alkenyl, C2- 6alkynyl, and C1-6alkoxy groups is optionally substituted with one to three substituents independently selected from halogen and CN.

11. The compound according to any one of the preceding claims, wherein R5is selected from C1-6alkyl, C1-6alkoxy, C3-6cycloalkyl, C3-6cycloalkyl-C1-6alkyl, and C1-6alkoxyC1-6alkyl, wherein each of said groups is optionally substituted with one to three substituents independently selected from halogen and CN.

12. A composition comprising a fungicidally effective amount of a compound as defined in any one ofclaims 1 to 11.

13. A composition according to claim 12, wherein the composition further comprises at least onecompound selected among an additional active ingredient, an appropriate formulation inert, a carrier, an adjuvant, and any mixtures thereof.

14. A method of combating, preventing or controlling phytopathogenic diseases which comprises applying to a phytopathogen, to the locus of a phytopathogen, to a plant susceptible to attack by a phytopathogen, or to a plant propagation material thereof, a fungicidally effective amount of a compoundaccording to any one of claims 1 to 11, or a composition comprising a compound according to any oneof claims 1 to 11, or a composition according to claim 12 or 13.

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