Hydrogel composition, preparation method therefor and use thereof

Abstract

A hydrogel composition and a preparation method therefor. The preparation method comprises: dispersing a carboxymethyl cellulose raw material and an alginic acid raw material in a solution, uniformly mixing same, then drying same to obtain a material A, and then mixing the material A with a calcium source to obtain the hydrogel composition. The composition forms a hydrogel after absorbing water, the water absorption rate of the composition is greater than or equal to 40 times, and the elastic modulus of the hydrogel is greater than or equal to 150 Pa. Further provided is the use of the composition in the preparation of digestive tract space-occupying products.

Description

Hydrogel composition, preparation method and application thereof

[0001] Cross-reference to related applications

[0002] The present disclosure claims priority to the application No. 2024108373460, filed on June 26, 2024, with the Chinese Patent Office, and entitled "Hydrogel composition, preparation method and application thereof", the entire content of which is incorporated herein by reference. TECHNICAL FIELD

[0003] The present disclosure relates to the field of food technology, in particular, to a hydrogel composition, a preparation method and application thereof. BACKGROUND

[0004] Obesity and diabetes are major public health problems in the world today, which have a serious impact on human health and quality of life. At present, the treatment methods for weight loss and diabetes mainly include drug therapy, diet control and surgery, etc. Among them, surgery is an effective treatment method, but the risk of surgery is large and the recovery time is long; and in the process of weight loss by drug therapy, there is often a problem of weight rebound after drug withdrawal, or the drug itself has some side effects; diet control is a safe and effective non-surgical treatment for weight loss, but it requires strong self-control of the weight loss person, so it is often difficult to achieve long-term and effective weight loss. In order to assist the weight loss person in controlling the diet, the weight loss person is usually required to eat some products with strong satiety, so it is of great significance to develop a safe and effective product to assist people in losing weight.

[0005] The prior art proposes some space-occupying gels in the digestive tract to increase satiety and achieve the purpose of weight loss. However, the space-occupying gels in the digestive tract at present are mostly synthesized by chemical crosslinking to ensure that the gels have high elastic modulus and high water absorption multiple. Although the obtained products have better performance, in the process of chemical crosslinking, the preparation process is relatively complex, and the yield is low after multi-step process, and the preparation cost is high, which limits the application of the space-occupying gel.

[0006] In summary, it is of great significance to provide a space-occupying gel with simple process, high elastic modulus and high water absorption multiple for the development of weight loss products.

[0007] In view of this, the present disclosure is proposed. SUMMARY

[0008] The present disclosure aims to provide a hydrogel composition, a preparation method and application thereof.

[0009] The present disclosure is implemented as follows:

[0010] In a first aspect, the present disclosure provides a hydrogel composition, raw materials including a carboxymethyl cellulose raw material, an alginic acid raw material and a calcium source, and the mass relationship of each component in the raw materials satisfies:

[0011] W1 = m2 / (m1+m2) x 100%, and 10%≤W1≤70%;

[0012] f = m4 / m3, and 0.09≤f≤5.00;

[0013] wherein m1 is the mass of the carboxymethyl cellulose raw material, m2 is the mass of the alginic acid raw material, m3 is the mass of the carboxyl in the alginic acid raw material, and m4 is the mass of Ca 2+ in the calcium source.

[0014] In a second aspect, the present disclosure provides a preparation method of the composition according to any one of the preceding embodiments, including dispersing the carboxymethyl cellulose raw material and the alginic acid raw material in a solution, mixing uniformly and then drying to obtain A material, and then mixing the A material with the calcium source to obtain the composition.

[0015] In a third aspect, the present disclosure provides a use of the composition according to any one of the preceding embodiments in preparing a digestive tract occupying product.

[0016] The present disclosure has the following beneficial effects:

[0017] The present disclosure provides a hydrogel composition, a preparation method and a use thereof. The composition can be quickly gelled in water, wherein the alginic acid raw material is physically cross-linked with calcium ions, and the carboxymethyl cellulose raw material can reduce the sensitivity of the alginic acid raw material to calcium ions, so as to facilitate the adjustment of the ratio of sodium alginate to the calcium source, so that the prepared hydrogel can greatly improve the elastic modulus of the hydrogel while retaining the medium water absorption rate. The chelation process of the composition is physical cross-linking and no chemical reaction occurs. The gelled hydrogel has high elastic modulus and excellent water absorption performance, can occupy the gastric volume in the stomach, and reduces food intake to achieve the purpose of weight loss and blood glucose control. BRIEF DESCRIPTION OF DRAWINGS

[0018] In order to more clearly illustrate the technical solutions of the embodiments of the present disclosure, the following will briefly introduce the drawings needed to be used in the embodiments. It should be understood that the following drawings only show some embodiments of the present disclosure, and therefore should not be regarded as a limitation on the scope. For those skilled in the art, other related drawings can also be obtained without creative labor on the basis of these drawings.

[0019] FIG. 1 is a weight loss effect line graph provided by the experimental example 2 of the present disclosure. DETAILED DESCRIPTION

[0020] The embodiments of this disclosure will be described in detail below with reference to examples. However, those skilled in the art will understand that the following examples are for illustrative purposes only and should not be considered as limiting the scope of this disclosure. Unless otherwise specified in the examples, conventional conditions or conditions recommended by the manufacturer shall apply. Reagents or instruments whose manufacturers are not specified are all commercially available conventional products.

[0021] The endpoints and any values ​​of the ranges disclosed in this disclosure are not limited to the precise ranges or values, and such ranges or values ​​should be understood to include values ​​close to such ranges or values. For numerical ranges, the endpoint values ​​of the various ranges, the endpoint values ​​of the various ranges and individual point values, and individual point values ​​can be combined with each other to obtain one or more new numerical ranges, which should be regarded as specifically disclosed herein.

[0022] Existing technology uses citric acid to chemically crosslink low molecular weight sodium carboxymethyl cellulose to obtain hydrogels with certain strength and water absorption properties. These hydrogels can increase satiety in the stomach, thereby achieving weight loss. However, the preparation process of this hydrogel involves chemical crosslinking, utilizing the hydroxyl groups in sodium carboxymethyl cellulose to generate ester bonds, thus achieving molecular-to-molecular linkage to obtain the hydrogel product. This preparation process is complex, has a low yield, and gel products obtained through chemical crosslinking are regulated as medical devices in many countries, resulting in a long overall product development cycle.

[0023] Based on existing chemical cross-linking methods, the inventors have discovered a key issue in the practical application of gastric volume-carrying hydrogels: the water absorption rate and elastic modulus of the hydrogel are often contradictory. Generally, when the water absorption rate of the medium increases, the hydrogel becomes softer, resulting in a lower elastic modulus and poorer mechanical properties, making it easier for the feeling of fullness to be lost under the peristalsis and pressure of the digestive tract. Conversely, when the water absorption rate decreases, the hydrogel becomes harder, resulting in a higher elastic modulus and better mechanical properties, but the reduced water absorption rate leads to a smaller volume, which also reduces the feeling of fullness.

[0024] Therefore, this disclosure not only requires the development of a non-chemical crosslinking method for preparing hydrogels, but also requires the simultaneous improvement of the hydrogel's medium water absorption rate and elastic modulus. Based on this, the inventors propose the following solution.

[0025] In a first aspect, this disclosure provides a hydrogel composition, the raw materials of which include carboxymethyl cellulose raw materials, alginate raw materials and calcium source, and the mass relationship of each component in the raw materials satisfies:

[0026] W1 = m2 / (m1+m2)×100%, and 10%≤W1≤70%.

[0027] f = m4 / m3, and 0.09 ≤ f ≤ 5.00.

[0028] wherein m1 is the mass of the carboxymethyl cellulose raw material, m2 is the mass of the alginic acid raw material, m3 is the mass of the carboxyl in the alginic acid raw material, and m4 is the mass of Ca2+ in the calcium source. 2+ The units of m1, m2, m3, and m4 are the same, for example, g or kg.

[0029] When the composition of the present disclosure is dispersed in water, the composition can be gelled to form a hydrogel. Specifically, the alginic acid raw material in the composition can chelate with calcium ions in a solution state to form a hydrogel, and physical crosslinking occurs to form a connection region called an "egg box structure". However, because the alginic acid raw material is highly sensitive to calcium ions, when the alginic acid raw material and the calcium source are mixed directly, the alginic acid raw material chelates with calcium ions in a solution state rapidly, and the hydrogel formed has high strength and poor water absorption capacity, and has poor gelation uniformity and stability. When used as a space-occupying gel in the digestive tract, the weight loss effect is not ideal.

[0030] Therefore, the applicant proposes adding a carboxymethyl cellulose raw material to the system of the alginic acid raw material and the calcium source. The carboxymethyl cellulose raw material can reduce the sensitivity of the alginic acid raw material to calcium ions, delay the gel point of gelation, and achieve controllable adjustment of the water absorption capacity and elastic modulus of the composition during gelation. By controlling the values of W1 and f, the hydrogel formed by the composition provided by the present disclosure not only has good water absorption capacity, but also has high elastic modulus.

[0031] Further, the composition of the present disclosure does not undergo a chemical reaction during preparation, and is a physical crosslinking process. The main molecular chain is formed by chelation of the alginic acid raw material and the calcium source. Compared to a chemical crosslinking process, which requires strict control of the molecular weight of the crosslinked molecules to control the water absorption capacity and elastic modulus of the hydrogel and other parameters, the composition provided by the present disclosure is easier to prepare and has a higher yield. In addition, the physical crosslinked hydrogel does not need to be managed as a medical device, and the development cost is lower.

[0032] When the composition of the present disclosure is dispersed in water, the composition rapidly absorbs water and swells, and forms a gel-like hydrogel. After the hydrogel is swallowed, the hydrogel enters the stomach through the esophagus. Because the hydrogel prepared from the composition of the present disclosure has high elastic modulus and excellent water absorption performance, it can occupy the gastric volume in the stomach, reduce food intake, and thus achieve the purposes of weight loss and blood glucose control.

[0033] To further optimize the water absorption and elastic modulus of the hydrogel formed after gelation of the composition provided by the present disclosure, the parameter ranges of W1 and f can be further controlled.

[0034] In optional embodiments, W1 satisfies: 10%≤W1≤60%, and f satisfies: 0.5≤f≤5.00.

[0035] More preferably, W1 satisfies: 15%≤W1≤45%, and f satisfies: 0.5≤f≤2.00.

[0036] For example, W1 can be 10%, 15%, 20%, 25%, 30%, 35%, 40%, 45%, 50%, 60%, or 70%, and a range value between any two of the above values. f can be 0.09, 0.50, 1.00, 1.50, 2.00, 2.50, 3.00, 3.50, 4.00, 4.50, or 5.00, and a range value between any two of the above values.

[0037] In optional embodiments, the composition forms a hydrogel after absorbing water, and the medium water absorption rate of the composition is ≥40 times, i.e., the composition provided by the present disclosure can absorb water of 40 times or more than the dry base mass of the composition; the elastic modulus of the hydrogel is ≥150 Pa; preferably, the elastic modulus of the hydrogel is ≥500 Pa.

[0038] By controlling the selection and ratio of the components of the composition in the present disclosure, the composition provided by the present disclosure has a good medium water absorption rate (the water absorption capacity can reach 40 times or more than the dry base mass of the composition) after forming a hydrogel, exhibits a high elastic modulus in simulated gastric juice, can achieve the effect of occupying the digestive tract and producing satiety of the hydrogel, and can assist in achieving the effect of weight loss.

[0039] Further, the selection of the source of the raw material is another factor for improving the performance of the hydrogel formed by the composition. For example, some literature reports that sodium alginate can form a gel in the stomach at pH to prolong the emptying time of the stomach, thereby reducing food intake and preventing obesity. However, due to the limitations of different sources, molecular weights, and molecular structures (the ratio between mannuronic acid and guluronic acid) of alginate, the weight loss effect varies greatly in different literature reports, which greatly limits the application of alginate in the field of weight loss.

[0040] In order to further improve the performance of the hydrogel, in optional embodiments, the viscosity of the alginate raw material in a solution at a concentration of 2% is ≥2000 mPa·S; preferably, the viscosity of the alginate raw material in a solution at a concentration of 2% is 4000-30000 mPa·S.

[0041] The viscosity of the carboxymethyl cellulose raw material in a solution at a concentration of 2% is ≥1000 mPa·S.

[0042] Due to the different molecular weight and molecular structure of the carboxymethyl cellulose raw material and the alginic acid raw material, different performances are exhibited. The present disclosure controls the viscosity range of the carboxymethyl cellulose raw material and the alginic acid raw material, thereby controlling the molecular weight and the molecular structure of the carboxymethyl cellulose raw material and the alginic acid raw material, and further improving the water absorption and the elastic modulus of the hydrogel formed by the composition.

[0043] Preferably, the carboxymethyl cellulose raw material includes but is not limited to carboxymethyl cellulose and its salts, the salts of carboxymethyl cellulose include any one of sodium carboxymethyl cellulose, potassium carboxymethyl cellulose and ammonium carboxymethyl cellulose, and any raw material having the structure of carboxymethyl cellulose can be used as a raw material for reducing the sensitivity of sodium alginate and the calcium source.

[0044] Preferably, the alginic acid raw material includes but is not limited to alginic acid and its salts, the salts of alginic acid include any one of sodium alginate, potassium alginate and ammonium alginate, and any raw material having the structure of alginic acid and its carboxyl group can be used as a raw material for chelating with the calcium source and physical cross-linking.

[0045] Preferably, the calcium source includes but is not limited to at least one of calcium carbonate, calcium chloride, calcium citrate, calcium lactate, calcium gluconate, calcium acetate or calcium phosphate; all products capable of providing calcium source can be used as the calcium source of the present disclosure. More preferably, the calcium source is a low solubility calcium source; more preferably, the low solubility calcium source is one of calcium lactate, calcium carbonate and calcium phosphate.

[0046] It should be noted that since the composition provided by the present disclosure needs to enter the digestive tract after forming the hydrogel to achieve the digestive tract occupation, thereby providing the satiety and achieving the weight loss effect, it can be understood that all components in the composition of the present disclosure are food-grade components to ensure that the hydrogel formed by the composition is edible.

[0047] The applicant further found that in the process of forming the occupation gel by the composition, the composition can be directly added to water, or different components in the composition can be added to water separately.

[0048] In an optional embodiment, when different components in the composition are added to water separately, the composition can also be packaged separately to facilitate the mixing order of the composition.

[0049] In an optional embodiment, the composition includes separately packaged A material and B material, the A material is a mixture of the carboxymethyl cellulose raw material and the alginic acid raw material, and the B material is the calcium source. The A material is configured to be mixed with the solution first, and the B material is configured to be added to the solution after the A material is dispersed to avoid the calcium source reacting rapidly with the alginic acid raw material, resulting in the decrease of the water absorption performance of the hydrogel.

[0050] Preferably, in order to ensure that the A material can be dispersed rapidly in the solution to form a colloidal suspension, the particle size of the A material is 0.1 mm to 2 mm, more preferably 0.3 mm to 2 mm, and more preferably 0.3 mm to 1 mm.

[0051] In a second aspect, the present disclosure provides a method for preparing the composition of any one of the preceding embodiments, comprising dispersing the carboxymethyl cellulose raw material and the alginic acid raw material in a solution, drying the mixture to obtain the A material, and then mixing the A material with a calcium source.

[0052] In an optional embodiment, the concentration of the polymer in the solution during the preparation of the A material is 1% to 10%, wherein the concentration of the polymer refers to the total concentration of the carboxymethyl cellulose raw material and the alginic acid raw material.

[0053] Preferably, the solution is water, and the drying temperature is 70°C to 150°C, and more preferably 70°C to 100°C.

[0054] The present disclosure provides a hydrogel composition which is in a solid state before gelation, and can be rapidly gelled to obtain a hydrogel after being added to water. After the hydrogel is consumed, the hydrogel can occupy the digestive tract, provide a feeling of satiety, reduce the frequency and amount of eating, and thus achieve weight loss and improve the symptoms of diabetes.

[0055] In a third aspect, the present disclosure provides a use of the composition of any one of the preceding embodiments in the preparation of a digestive tract occupying product.

[0056] In an optional embodiment, the method for using the composition provided by the present disclosure comprises adding the entire solid composition to water and stirring, or adding the mixture of the carboxymethyl cellulose raw material and the alginic acid raw material to water and stirring to obtain a pre-gel suspension, and then adding the calcium source to the pre-gel suspension and stirring to obtain the hydrogel.

[0057] That is, when the composition is packaged as the A material and the B material, the A material is first added to water and stirred to obtain a pre-gel suspension, and then the B material is added to water and stirred to obtain the hydrogel.

[0058] In an optional embodiment, in order to ensure that the components in the raw materials are mixed uniformly, the stirring time for each of the two times of stirring is 2 to 5 minutes, and in order to obtain a hydrogel with a complete shape, it is necessary to ensure that the liquid does not generate vortexes during the stirring process.

[0059] Example 1

[0060] This embodiment provides a hydrogel composition which is composed of an A material and a B material, the A material is sodium carboxymethyl cellulose and sodium alginate, and the B material is calcium lactate.

[0061] The mass of the sodium carboxymethyl cellulose is 20 g, and the viscosity is 8000 mPa·S when the concentration in the solution is 2%.

[0062] The mass of the sodium alginate is 2.5 g, and the viscosity is 5800 mPa·S when the concentration in the solution is 2%.

[0063] The preparation method of the above-mentioned hydrogel composition also comprises the following steps:

[0064] The 2.5 g of sodium alginate is added into 500 mL of water and stirred and dispersed, and then 20 g of sodium carboxymethyl cellulose is added into the water, and the sodium alginate, the sodium carboxymethyl cellulose and the water are mixed under mechanical stirring at 1000 rpm to form a uniform suspension. The suspension is transferred into a metal tray, the thickness of the suspension in the metal tray is controlled to be below 1 cm, and then the metal tray is placed in an oven at 70°C for drying for 24 h to obtain a solid A material. The solid A material is crushed in a crusher and sieved through 10 mesh and 120 mesh sieves to obtain granular A material with a particle size of 0.1-2 mm, which is packaged for use.

[0065] The calcium lactate is packaged as B material, and the mass of the calcium lactate in the B material and the mass of the sodium alginate in the A material satisfy f=3.0.

[0066] The use method of the above-mentioned hydrogel composition also comprises the following steps: first, the A material is added into water and stirred for 5 min to obtain a pre-gel suspension, and then the B material is added into the pre-gel suspension and stirred for 5 min. In the stirring process, no vortex is generated in the liquid. After the stirring is completed, a hydrogel is obtained, and the user swallows the hydrogel, and the hydrogel plays its space-occupying effect in the digestive tract.

[0067] Example 2

[0068] The hydrogel composition comprises A material and B material, the A material is sodium carboxymethyl cellulose and sodium alginate, and the B material is calcium lactate.

[0069] The mass of the sodium carboxymethyl cellulose is 20 g, and the viscosity is 8000 mPa·S when the concentration in the solution is 2%.

[0070] The mass of the sodium alginate is 5 g, and the viscosity is 5800 mPa·S when the concentration in the solution is 2%.

[0071] The preparation method of the above-mentioned hydrogel composition also comprises the following steps:

[0072] 5g sodium alginate was added into 500mL water and stirred to disperse, then 20g sodium carboxymethyl cellulose was added into the water, and the sodium alginate, sodium carboxymethyl cellulose and water were mixed under mechanical stirring at 1000rpm to form a uniform suspension. The suspension was transferred into a metal tray, the thickness of the suspension in the metal tray was controlled to be below 1cm, and then the metal tray was placed in an oven at 90℃ for drying for 24h to obtain solid A material. The solid A material was crushed in a crusher, and sieved through 10 mesh and 120 mesh sieves to obtain granular A material with a particle size of 0.1-2mm, which was packaged for use.

[0073] The calcium lactate was packaged as B material, and the mass of the calcium lactate in the B material and the mass of the sodium alginate in the A material satisfied f = 0.61.

[0074] The use method of the hydrogel composition provided in this embodiment is as described in Embodiment 1.

[0075] Embodiment 3

[0076] This embodiment provides a hydrogel composition, which is composed of A material and B material, the A material is sodium carboxymethyl cellulose and sodium alginate; and the B material is calcium lactate.

[0077] The mass of the sodium carboxymethyl cellulose is 20g, and the viscosity is 8000mPa·S when the concentration in the solution is 2%.

[0078] The mass of the sodium alginate is 5g, and the viscosity is 5800mPa·S when the concentration in the solution is 2%.

[0079] This embodiment also provides a preparation method of the above hydrogel composition, which comprises the following steps:

[0080] 5g sodium alginate was added into 500mL water and stirred to disperse, then 20g sodium carboxymethyl cellulose was added into the water, and the sodium alginate, sodium carboxymethyl cellulose and water were mixed under mechanical stirring at 1000rpm to form a uniform suspension. The suspension was transferred into a metal tray, the thickness of the suspension in the metal tray was controlled to be below 1cm, and then the metal tray was placed in an oven at 70℃ for drying for 24h to obtain solid A material. The solid A material was crushed in a crusher, and sieved through 10 mesh and 120 mesh sieves to obtain granular A material with a particle size of 0.1-2mm, which was packaged for use.

[0081] The calcium lactate was packaged as B material, and the mass of the calcium lactate in the B material and the mass of the sodium alginate in the A material satisfied f = 0.76.

[0082] The use method of the hydrogel composition provided in this embodiment is as described in Embodiment 1.

[0083] Embodiment 4

[0084] The embodiment provides a hydrogel composition, which is composed of A material and B material, the A material is sodium carboxymethyl cellulose and sodium alginate; and the B material is calcium lactate.

[0085] The mass of the sodium carboxymethyl cellulose is 20 g, and the viscosity is 8000 mPa·S when the concentration in the solution is 2%.

[0086] The mass of the sodium alginate is 5 g, and the viscosity is 5800 mPa·S when the concentration in the solution is 2%.

[0087] The embodiment further provides a preparation method of the hydrogel composition, and the method comprises the following steps:

[0088] 5 g of sodium alginate is added into 500 mL of water and stirred and dispersed, then 20 g of sodium carboxymethyl cellulose is added into the water, the sodium alginate, the sodium carboxymethyl cellulose and the water are mixed under mechanical stirring at 1000 rpm to form a uniform suspension, the suspension is transferred into a metal tray, the thickness of the suspension in the metal tray is controlled to be below 1 cm, then the metal tray is placed in an oven at 70 DEG C and dried for 24 h to obtain solid A material, the solid A material is crushed in a crusher, and is screened through 10-mesh and 120-mesh screen meshes, so that granular A material with a particle size of 0.1-2 mm is obtained, and the granular A material is packaged.

[0089] The calcium lactate is packaged as B material, and the mass of the calcium lactate in the B material and the mass of the sodium alginate in the A material satisfy f=1.51.

[0090] The embodiment provides a use method of the hydrogel composition.

[0091] Embodiment 5

[0092] The embodiment provides a hydrogel composition, which is composed of A material and B material, the A material is sodium carboxymethyl cellulose and sodium alginate; and the B material is calcium lactate.

[0093] The mass of the sodium carboxymethyl cellulose is 5 g, and the viscosity is 8000 mPa·S when the concentration in the solution is 2%.

[0094] The mass of the sodium alginate is 10 g, and the viscosity is 5800 mPa·S when the concentration in the solution is 2%.

[0095] The embodiment further provides a preparation method of the hydrogel composition, and the method comprises the following steps:

[0096] 10g of sodium alginate was added into 500mL of water and stirred to disperse, and then 5g of sodium carboxymethyl cellulose was added into the water, and the sodium alginate, sodium carboxymethyl cellulose and water were mixed under mechanical stirring at 1000rpm to form a uniform suspension. The suspension was transferred into a metal tray, the thickness of the suspension in the metal tray was controlled to be below 1cm, and then the metal tray was placed in an oven at 70℃ for drying for 24h to obtain solid A material. The solid A material was crushed in a crusher, and sieved through 10-mesh and 120-mesh sieves to obtain granular A material with a particle size of 0.1-2mm, which was packaged for use.

[0097] The calcium lactate was packaged as B material, and the mass of the calcium lactate in the B material and the mass of the sodium alginate in the A material satisfied f = 0.09.

[0098] The use method of the hydrogel composition provided in this embodiment is as described in Embodiment 1.

[0099] Embodiment 6

[0100] This embodiment provides a hydrogel composition, which is composed of A material and B material, the A material is sodium carboxymethyl cellulose and sodium alginate, and the B material is calcium lactate.

[0101] The mass of the sodium carboxymethyl cellulose is 5g, and the viscosity is 8000mPa·S when the concentration in the solution is 2%.

[0102] The mass of the sodium alginate is 10g, and the viscosity is 5800mPa·S when the concentration in the solution is 2%.

[0103] This embodiment also provides a preparation method of the above hydrogel composition, which comprises the following steps:

[0104] 10g of sodium alginate was added into 500mL of water and stirred to disperse, and then 5g of sodium carboxymethyl cellulose was added into the water, and the sodium alginate, sodium carboxymethyl cellulose and water were mixed under mechanical stirring at 1000rpm to form a uniform suspension. The suspension was transferred into a metal tray, the thickness of the suspension in the metal tray was controlled to be below 1cm, and then the metal tray was placed in an oven at 90℃ for drying for 24h to obtain solid A material. The solid A material was crushed in a crusher, and sieved through 10-mesh and 120-mesh sieves to obtain granular A material with a particle size of 0.1-2mm, which was packaged for use.

[0105] The calcium lactate was packaged as B material, and the mass of the calcium lactate in the B material and the mass of the sodium alginate in the A material satisfied f = 0.57.

[0106] Embodiment 7

[0107] The present embodiment provides a hydrogel composition, which is composed of A material and B material, the A material is sodium carboxymethyl cellulose and sodium alginate; the B material is calcium lactate. The preparation method of the A material is the same as that of Example 3, and the f value is 0.76.

[0108] The use method of the hydrogel composition provided by the present embodiment includes adding the A material and the B material into water at the same time and stirring for 5-10 min, no vortex is generated in the liquid during the stirring process, and the hydrogel is obtained after the stirring is completed. The user swallows the hydrogel, and the hydrogel plays its space-occupying effect in the digestive tract.

[0109] Comparative Example 1

[0110] The present comparative example provides a hydrogel composition, which is similar to Example 6, and the only difference is that the A material only includes 10 g of sodium alginate, and f = 0.07.

[0111] Comparative Example 2

[0112] The present comparative example provides a hydrogel composition, which is different from Example 4 in that the preparation method of the granular material A is different, and the A material only contains sodium alginate, so it does not need to go through the steps of dissolution, drying and crushing. Then, the granular B material calcium lactate is physically mixed with the A material according to the f value ratio in Example 4, and is ready for packaging.

[0113] Comparative Example 3

[0114] The present comparative example provides a hydrogel composition, which is similar to Example 4, and the only difference is that the preparation method of the above hydrogel composition does not perform the operation of dissolving, drying and crushing the sodium alginate and sodium carboxymethyl cellulose, but directly mixes the three raw materials in the form of powder.

[0115] Comparative Example 4

[0116] The present comparative example provides a hydrogel composition, which is similar to Example 4, and the only difference is that the sodium carboxymethyl cellulose is replaced by carboxymethyl chitosan.

[0117] Experimental Example 1

[0118] 1) Detection in simulated gastric juice:

[0119] According to the fourth part of “People's Republic of China Pharmacopoeia 2020”, artificial gastric juice is prepared, then diluted 8 times, and the pH is adjusted to 2.1, which is used as artificial gastric juice (hereinafter referred to as simulated gastric juice) simulating half an hour before meal.

[0120] Take 60 mL of simulated gastric juice on a magnetic stirrer, the stirring speed is 100 rpm, respectively, 0.6 g of A material of examples 1-6 and comparative examples 1-4 is slowly added to the above simulated gastric juice, after stirring for 5 min, according to the f value of examples 1-4 and comparative examples 1-4, slowly add B material to the above simulated gastric juice, continue to stir for 5 min, for the treatment process of simulated gastric juice.

[0121] Take a piece of 150 mesh gauze and weigh it, record it as g1, then filter the above stirred mixture with 150 mesh gauze to remove the unabsorbed simulated gastric juice (when filtering, pay attention to scraping the liquid on the surface of the gauze with your hand, until there is no liquid on your hand visible to the naked eye, it is finished), weigh the mixture and gauze together and record it as g2, and observe the state of the hydrogel obtained after filtration.

[0122] Calculate the medium water absorption rate MUR of the hydrogel composition in the simulated gastric juice = (g2-g1) / 0.6. The elastic modulus G' of the filtered hydrogel is determined by rheometer (the corresponding value at a uniform angular frequency of 10 rad / s), and the results are shown in Table 1.

[0123] Table 1 Hydrogel composition and performance of hydrogel

[0124] As can be seen from Table 1, the hydrogel composition provided by the embodiments of the present disclosure can have a medium water absorption rate of up to 73.11 times the original weight after becoming a hydrogel. In addition, the hydrogel composition provided by the embodiments of the present disclosure can still maintain a high level of elastic modulus while absorbing a large amount of water, which can prolong the time of having a feeling of satiety and improve the weight loss effect. Comparative examples 1 and 2 only added sodium alginate, and their water absorption performance and elastic modulus decreased significantly at a lower f value. The gel prepared at a higher f value has strong strength, but its water absorption performance decreases sharply, and it is difficult to play a weight loss effect as a digestive tract occupying gel. Comparative example 3 changes the preparation method of the hydrogel composition, which causes the morphology of the hydrogel composition to change and be difficult to form, and the paste-shaped product formed cannot be made into a hydrogel, so it also cannot play a weight loss effect as a digestive tract occupying gel. Comparative example 4 changes the raw materials of the hydrogel composition, and the hydrogel composition obtained due to the interaction of charges is easy to form a group and is difficult to be used for weight loss products.

[0125] Experimental example 2

[0126] 20 volunteers were recruited and randomly divided into two groups, the control group took the same amount of sucrose, and the experimental group took 3g of the hydrogel composition of Example 4 at two meals per day. The drinking time was 30min before meals, twice a day, at noon and dinner in the afternoon. At the same time, the volunteers were given nutritional intervention, and the daily caloric intake was reduced by 300kcal. The body weight of the volunteers was recorded every 4 weeks for 24 weeks, and the weight loss rate TWL=(initial weight-follow-up weight) / initial weight was calculated, and the results are shown in Figure 1.

[0127] As can be seen from Figure 1, through nutritional intervention and the use of the hydrogel composition provided by the present disclosure, a good weight loss effect is achieved, and the weight loss rate is between 6-8% within 24 weeks, and the weight loss effect is significantly, while the weight loss effect of the control group is less than 3%. It shows that the hydrogel composition provided by the present disclosure has a good weight loss effect.

[0128] The hydrogel composition provided by the present disclosure has at least the following advantages:

[0129] 1) The hydrogel composition provided by the present disclosure is prepared from food-grade raw materials and can be directly used as food.

[0130] 2) The present disclosure uses alginic acid raw materials and calcium source to prepare the hydrogel composition and form the hydrogel by physical cross-linking. Compared with the hydrogel prepared by chemical cross-linking method, the preparation process is simpler, and the yield is higher, which is conducive to large-scale production.

[0131] 3) In the chelation system of alginic acid raw materials and calcium source, carboxymethyl cellulose raw materials are added, which can reduce the sensitivity of alginic acid raw materials to calcium ions, and realize the controllable adjustment of water absorption capacity and elastic modulus of the hydrogel composition in the process of gelation. By controlling the values of W1 and f, the hydrogel formed by the hydrogel composition provided by the present disclosure not only has good water absorption capacity, but also has high elastic modulus.

[0132] 4) The hydrogel composition prepared by the present disclosure can quickly absorb water to form a gel after meeting water. Since the hydrogel prepared by the hydrogel composition of the present disclosure has high elastic modulus and excellent water absorption performance, it can occupy the gastric volume in the stomach, resist gastric peristalsis, maintain high satiety to reduce food intake, and achieve the purpose of weight loss and blood glucose control.

[0133] The above is only a preferred embodiment of the present disclosure and is not intended to limit the present disclosure. For those skilled in the art, the present disclosure can have various modifications and changes. Any modification, equivalent replacement, improvement, etc. made within the spirit and principles of the present disclosure shall be included in the protection scope of the present disclosure. Industrial applicability

[0134] The present disclosure provides a hydrogel composition, a preparation method and application thereof, which is prepared by using food-grade raw materials, can be directly used as food, and has a simpler preparation process and higher yield, which is conducive to large-scale production.

Claims

1. A hydrogel composition, characterized by, The raw materials include carboxymethyl cellulose raw materials, alginic acid raw materials and calcium sources, and the mass relationship of the components in the raw materials satisfies: W1=m2 / (m1+m2)×100%, and 10%≤W1≤70%; f=m4 / m3, and 0.09≤f≤5.00; wherein m1 is the mass of the carboxymethyl cellulose-based raw material, m2 is the mass of the alginic acid-based raw material, m3 is the mass of the carboxyl group in the alginic acid-based raw material, and m4 is the mass of Ca in the calcium source. 2+ wherein m1 is the mass of the carboxymethyl cellulose-based raw material, m2 is the mass of the alginic acid-based raw material, m3 is the mass of the carboxyl group in the alginic acid-based raw material, and m4 is the mass 2. The composition of claim 1, wherein, The W1 satisfies: 10%≤W1≤60%, and the f satisfies: 0.5≤f≤5.00; More preferably, the W1 satisfies: 15%≤W1≤45%, and the f satisfies: 0.5≤f≤2.

00.

3. The composition according to claim 1 or 2, characterized in that, The composition forms a hydrogel after absorbing water, the medium water absorption rate of the composition is ≥40 times, and the elastic modulus of the hydrogel is ≥150 Pa; preferably, the elastic modulus of the hydrogel is ≥500 Pa.

4. The composition of claim 1, wherein, The viscosity of the carboxymethyl cellulose raw materials in a solution is ≥1000 mPa·S when the concentration is 2%; Preferably, the carboxymethyl cellulose raw materials include carboxymethyl cellulose and salts thereof, and the salts of the carboxymethyl cellulose include any one of sodium carboxymethyl cellulose, potassium carboxymethyl cellulose and ammonium carboxymethyl cellulose.

5. The composition of claim 1, wherein, The viscosity of the alginic acid raw materials in a solution is ≥2000 mPa·S when the concentration is 2%; Preferably, the alginic acid raw materials include alginic acid and salts thereof, and the salts of the alginic acid include any one of sodium alginate, potassium alginate and ammonium alginate.

6. The composition of claim 1, wherein, The calcium source includes at least one of calcium carbonate, calcium chloride, calcium citrate, calcium lactate, calcium gluconate, calcium acetate or calcium phosphate; more preferably, the calcium source is a calcium source with low solubility; more preferably, the calcium source with low solubility is one of calcium lactate, calcium carbonate and calcium phosphate.

7. The composition of claim 1, wherein, The particle size of the composition is 0.1 mm to 2 mm, more preferably 0.3 mm to 2 mm, and more preferably 0.3 mm to 1 mm.

8. A process for the preparation of a composition according to any one of claims 1 to 7, characterised in that, The method includes: The carboxymethyl cellulose raw materials and the alginic acid raw materials are dispersed in a solution, mixed uniformly, dried to obtain A materials, and then mixed with calcium sources to obtain the composition.

9. The preparation method according to claim 8, characterized in that, In the preparation process of the A materials, the concentration of the polymers in the solution is 1% to 10%, the A materials are obtained after being mixed uniformly and dried, and then mixed with calcium sources to obtain the composition; The drying temperature is 70°C to 150°C; preferably, the drying temperature is 70°C to 100°C.

10. Use of the composition according to any one of claims 1 to 7 in the preparation of a product for occupying the digestive tract.

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