Hydrogel-plasma generator integrated patch capable of supporting reactive species and / or useful substances

Abstract

The present application provides a hydrogel-plasma generator-integrated patch capable of supporting reactive species and / or useful substances. More specifically, the present application provides a hydrogel-plasma generator-integrated patch capable of supporting reactive species and / or useful substances, which is used by being attached to the skin and simultaneously treat skin diseases and / or wounds while exhibiting synergistic antimicrobial effects and controlled release of useful substances.

Description

A hydrogel-plasma generator-integrated patch capable of carrying active species and / or useful substances

[0001] The present invention relates to a hydrogel-plasma generator-integrated patch capable of carrying active species and / or useful substances. More specifically, the present invention relates to a hydrogel-plasma generator-integrated patch capable of carrying active species and / or useful substances, which is applied to the skin to treat skin diseases and / or wounds while simultaneously exhibiting synergistic antimicrobial effects and controlled release of useful substances.

[0002]

[0003] Hydrogels are gels that use water as a dispersion medium. Hydrogels are formed when hydrosols lose their fluidity upon cooling, or when hydrophilic polymers with three-dimensional network and microcrystalline structures swell upon containing water. Many hydrogels made of electrolyte polymers exhibit high absorbency and are widely used as absorbent polymers.

[0004] Specifically, hydrogels are polymer structures that are used in medical applications such as wound dressings, cosmetic and skin care, scar treatment, drug delivery systems, and bioscaffolds, as well as in cooling applications such as ice packs.

[0005] In particular, hydrogels can provide moisture to wounds, isolate the nerve area of ​​the damaged wound from air to relieve skin pain, and prevent contamination from the outside through a sterile barrier.

[0006] However, hydrogels can be difficult to treat skin diseases on their own, and have limitations in inactivating bacteria, fungi, and viruses present in the wound area. In addition, if pathogens are present in the wound area, maintaining a moist environment can actually worsen the symptoms.

[0007] The background technology of this invention is described in Korean Patent Publication No. 10-2021-0147652, which describes a hydrogel with excellent wettability and strength.

[0008]

[0009] The purpose of the present invention is to provide a hydrogel-plasma generator integrated patch capable of carrying active species and / or useful substances capable of treating skin diseases and / or inactivating microorganisms at a wound site.

[0010] Another object of the present invention is to provide a hydrogel-plasma generator integrated patch capable of carrying active species and / or useful substances capable of inducing an antimicrobial synergistic effect.

[0011] Another object of the present invention is to provide a hydrogel-plasma generator integrated patch capable of carrying an active species and / or a useful substance capable of promoting transdermal delivery of a useful substance.

[0012] Other objects and advantages of the present invention will become more apparent from the detailed description, claims and drawings below.

[0013]

[0014] According to one aspect, a hydrogel-plasma generator integrated patch is provided, comprising: a body part having an opening on at least one side; a plasma generator provided inside the body part; and a hydrogel provided on at least one side of the plasma generator and on the open side of the body part, the hydrogel carrying at least one of an active species and a useful substance.

[0015] According to one embodiment, the hydrogel-plasma generator integrated patch of the present invention can control the amount of release of a useful substance loaded in the hydrogel by controlling the plasma generated from the plasma generator.

[0016] According to one embodiment, the hydrogel-plasma generator integrated patch of the present invention can load one or more active oxygen species and nitrogen species into the hydrogel by driving the plasma generator, and then stop driving the plasma generator and treat one or more of the loaded active oxygen species and nitrogen species onto the skin.

[0017] According to one embodiment, the hydrogel-plasma generator integrated patch of the present invention can induce skin disease treatment and antimicrobial action of one or more types of active oxygen species and nitrogen species generated by plasma from the plasma generator and useful substances contained in the hydrogel.

[0018] According to one embodiment, in the hydrogel-plasma generator integrated patch of the present invention, the opening of the body part may be provided to be openable and closable.

[0019] According to one embodiment, in the hydrogel-plasma generator integrated patch of the present invention, a mounting portion on which the plasma generator is mounted may be provided on the inside of the body portion.

[0020] According to one embodiment, in the hydrogel-plasma generator integrated patch of the present invention, the plasma generator includes a dielectric layer; a first electrode formed on one side of the dielectric layer; and a second electrode formed on the other side of the dielectric layer, and at least one of the first electrode and the second electrode may be arranged in a certain pattern.

[0021] According to one embodiment, in the hydrogel-plasma generator integrated patch of the present invention, the plasma generator may be a low-temperature atmospheric pressure plasma generator operated by a low-frequency power source.

[0022] According to one embodiment, in the hydrogel-plasma generator integrated patch of the present invention, the hydrogel may be provided to be detachable from the body portion.

[0023] According to one embodiment, in the hydrogel-plasma generator integrated patch of the present invention, the hydrogel may be provided at a certain distance from the plasma generator.

[0024]

[0025] According to one embodiment of the present invention, the hydrogel-plasma generator integrated patch of the present invention includes a hydrogel capable of carrying an active species and / or a useful substance and is skin-adhesive, so that it can simultaneously enhance the effect of treating skin diseases and the effect of inactivating microorganisms at a wound site.

[0026] According to one embodiment of the present invention, the hydrogel-plasma generator integrated patch of the present invention can induce an antimicrobial synergy effect by releasing useful substances contained in the hydrogel into the skin through oxygen-activated species generated by plasma, thereby treating skin diseases and inactivating microorganisms present in the wound area.

[0027] According to one embodiment of the present invention, the hydrogel-plasma generator integrated patch of the present invention can promote transdermal delivery of a useful substance loaded in the hydrogel by the activity of the active species.

[0028] According to one embodiment of the present invention, the hydrogel-plasma generator integrated patch of the present invention can maximize the treatment effect by controlling the amount of useful substances contained in the hydrogel by controlling the plasma generation conditions.

[0029] According to one embodiment of the present invention, the hydrogel-plasma generator integrated patch of the present invention can treat the skin with high concentrations of active oxygen species and nitrogen species for a short period of time by turning on the power of the plasma generator when necessary, and can treat the skin with low concentrations of active oxygen species and nitrogen species contained in the hydrogel for a long period of time without turning on the power of the plasma generator.

[0030]

[0031] FIG. 1 is a schematic diagram showing a hydrogel-plasma generator integrated patch structure capable of carrying active species and / or useful substances according to one embodiment of the present invention and a mechanism for treating skin diseases and / or wounds using the same.

[0032] FIG. 2 is a photograph showing a flexible plasma generator equipped in an integrated patch of a hydrogel-plasma generator capable of carrying active species and / or useful substances according to one embodiment of the present invention.

[0033] FIG. 3 is a photograph showing a hydrogel capable of carrying an active species and / or a useful substance, which is provided in a patch integrated with a hydrogel-plasma generator capable of carrying an active species and / or a useful substance according to one embodiment of the present invention.

[0034]

[0035] The above-described purposes, means, and resulting effects of this application will be further clarified through the following detailed description, which is illustrated in the attached drawings. Accordingly, those skilled in the art will be able to readily implement the technical concepts of this application. Furthermore, in explaining this application, if a detailed description of known technology related to this application is deemed likely to unnecessarily obscure the gist of this application, such detailed description will be omitted.

[0036] The terminology used herein is for the purpose of describing embodiments and is not intended to limit the present invention. In this specification, singular forms also include plural forms, unless specifically stated otherwise. In this specification, terms such as "include," "provide," "provide," or "have" do not exclude the presence or addition of one or more other components other than the components mentioned.

[0037] In this specification, terms such as "or", "at least one", etc. may refer to one of the words listed together, or to a combination of two or more. For example, "or B", "and at least one of B" may include only one of A or B, or may include both A and B.

[0038] In this specification, descriptions using the phrase "for example" or the like should not be construed as limiting the embodiments of the invention according to the various embodiments of the present disclosure by the effect of variations such as tolerances, measurement errors, limitations of measurement accuracy, and other commonly known factors, as the information presented may not be exactly the same as the cited characteristics, variables, or values.

[0039] In this specification, when a component is described as being "connected" or "connected" to another component, it should be understood that it may be directly connected or connected to that other component, but that there may be other components in between. Conversely, when a component is described as being "directly connected" or "directly connected" to another component, it should be understood that there are no other components in between.

[0040] In this specification, when a component is described as being "on" or "in contact with" another component, it should be understood that it may be directly on or connected to the other component, but there may be another component in between. Conversely, when a component is described as being "directly on" or "in direct contact with" another component, it should be understood that there is no other component in between. Other expressions that describe the relationship between components, such as "between" and "directly between," can be interpreted similarly.

[0041] In this specification, terms such as "first" and "second" may be used to describe various components, but the components should not be limited by these terms. Furthermore, these terms should not be construed to limit the order of each component, but rather may be used to distinguish one component from another. For example, a "first component" may be referred to as a "second component," and similarly, a "second component" may also be referred to as a "first component."

[0042] Unless otherwise defined, all terms used in this specification may be used in their common sense by those of ordinary skill in the technical field to which this disclosure pertains. Furthermore, terms defined in commonly used dictionaries are not to be interpreted ideally or excessively unless explicitly defined otherwise.

[0043] In this study, microorganisms include bacteria, fungi, viruses, etc.

[0044]

[0045] Hereinafter, a preferred embodiment according to the present invention will be described in detail with reference to the attached drawings.

[0046] FIG. 1 is a schematic diagram showing a hydrogel-plasma generator integrated patch structure capable of carrying active species and / or useful substances according to one embodiment of the present invention and a mechanism for treating skin diseases and / or wounds using the same.

[0047] Referring to FIG. 1, a hydrogel-plasma generator integrated patch according to one aspect of the present invention comprises a body part (1) having an opening (1c) on at least one side; a plasma generator (10) provided inside the body part (1); and a hydrogel (20) provided on at least one side of the plasma generator (10) and on the opening (1c) side of the body part (1) and containing at least one of an active species and a useful substance; and is attached to the skin.

[0048] According to the above-described configuration, one or more types of active oxygen species and nitrogen species generated by plasma generated from the plasma generator (10) and the useful substance contained in the hydrogel (20) can induce skin disease treatment and antimicrobial action.

[0049] More specifically, one or more types of active oxygen species and nitrogen species generated by plasma generated from the plasma generator (10) are loaded into the hydrogel (20) and then released onto the skin of a subject requiring treatment to treat skin diseases or inactivate microorganisms such as bacteria, fungi, and viruses present in wound areas, etc.

[0050] Therefore, the hydrogel-plasma generator integrated patch of the present invention can use the plasma generator (10) alone when necessary, and can treat the skin with high concentrations of active oxygen species and nitrogen species for a relatively short period of time (for example, within about 10 minutes) by driving the plasma generator (10). In addition, the hydrogel-plasma generator integrated patch of the present invention can treat the skin with active oxygen species and nitrogen species loaded into the hydrogel (20) by driving the plasma generator (10), and then stop driving the plasma generator (10) and treat the active oxygen species and nitrogen species loaded into the hydrogel (20) at a low concentration (for example, ozone 1 ppm) for a relatively long period of time (for example, about 1 hour or more) by driving the plasma generator (10).

[0051]

[0052] In addition, when a useful substance is loaded onto the hydrogel (20), the release of the useful substance loaded onto the hydrogel (20) is promoted by the active oxygen species generated by the plasma generated from the plasma generator (10), and the useful substance, active oxygen species, and active nitrogen species are delivered together to the skin of the subject requiring treatment to treat skin diseases or inactivate microorganisms such as bacteria, fungi, and viruses existing in wounded areas. Therefore, according to the present invention, a synergistic effect can be induced for the treatment of skin diseases and the antimicrobial action against pathogens existing on the skin such as wounded areas, and the antimicrobial action by active oxygen species and nitrogen species can be exerted against drug-resistant microorganisms. In addition, secondary infection or itching can be suppressed through the control of microorganisms in the skin disease or wounded areas as described above.

[0053]

[0054] Although not limited thereto, the hydrogel-plasma generator integrated patch of the present invention can control the amount of release of a useful substance loaded in the hydrogel (20) by controlling the plasma (P) generated from the plasma generator (10). The active oxygen species generated by the plasma generated from the plasma generator (10) can promote the release of the useful substance loaded in the hydrogel (20). Therefore, by controlling the amount of plasma generated by the plasma generator (10), the useful substance loaded in the hydrogel (20) can be released in a customized manner according to the needs of the subject to be treated.

[0055] In addition, but not limited thereto, the hydrogel-plasma generator integrated patch of the present invention can control the amount of useful substances carried in the hydrogel (20) absorbed by the subject by controlling the plasma (P) generated from the plasma generator (10). It is known that the penetration of useful substances such as drugs through the skin is very limited by the skin barrier called the stratum corneum. Therefore, excessive use of drugs such as steroids can cause side effects such as skin infection and pigmentation. The reactive oxygen species generated by the plasma generated from the plasma generator (10) of the present invention can promote the penetration and absorption of useful substances carried in the hydrogel (20) and then released through changes in the stratum corneum of the skin and rearrangement of intercellular lipids. Therefore, by controlling the amount of plasma generated by the plasma generator (10), the useful substances carried in the hydrogel (20) can be absorbed in a customized manner according to the needs of the subject to be treated. Therefore, it is possible to reduce the amount of medication used, such as steroids, for treating atopic dermatitis and prevent problems caused by excessive medication use.

[0056]

[0057] There is no special limitation on the above body part (1) as long as it can be equipped with the plasma generating device (10) and the hydrogel (20).

[0058] Although not limited thereto, a first mounting portion may be provided on the inside of the body portion (1) to which an end of the plasma generating device (10) is mounted. In addition, a second mounting portion may be provided on the inside of the body portion (1) to which an end of the hydrogel (20) is mounted. According to the above configuration, the plasma generating device (10) and the hydrogel (20) can be stably mounted on the body portion (1). The shapes and structures of the first mounting portion and the second mounting portion can be formed in various ways using known techniques, and in the present invention, a first mounting groove (1a) and a second mounting groove (1b) are provided as examples. The first and second mounting grooves (1a, 1b) are grooves formed to extend from the inside of the body portion (1) to the center so that an end of the plasma generating device (10) or an end of the hydrogel (20) is fitted therein.

[0059] At least one side of the body portion (1) is provided with an opening (1c) so that the plasma generating device (10) and / or the hydrogel (20) are configured to come into contact with the skin to be treated.

[0060] Although not limited thereto, the opening (1c) of the body portion (1) may be configured to be opened and closed. According to the above configuration, when the hydrogel-plasma generator integrated patch is not used, it is possible to prevent the active species generated by the plasma generator (10) from being released to the outside or the hydrogel (20) from being contaminated by external contaminants.

[0061] Although not limited thereto, the opening (1c) of the body part (1) may be provided on both sides of the body part (1) so as to be openable. According to the above configuration, when the plasma generator (10) is driven and the opening (1c) on the plasma generator (10) side is opened to treat the skin, treatment of skin diseases and / or an antimicrobial effect by the active species can be achieved. In addition, when the plasma generator (10) is driven and the active species generated thereby are contained in the hydrogel (20), and then the opening (1c) on the hydrogel (20) side is opened to treat the skin, treatment of skin diseases and / or an antimicrobial effect by the active species and / or a useful substance can be achieved.

[0062]

[0063] Although not limited thereto, the plasma generating device (10) of the present invention includes a dielectric layer (12); a first electrode (14) formed on one side of the dielectric layer (12); and a second electrode (16) formed on the other side of the dielectric layer (12), and at least one of the first electrode (14) and the second electrode (16) may be arranged in a certain pattern.

[0064] The above dielectric layer (12) is configured to insulate the voltage application electrode, and the above dielectric layer (12) may or may not be composed of a flexible dielectric.

[0065] FIG. 2 is a photograph showing a flexible plasma generator (10) having a dielectric layer (120) made of a flexible dielectric in an integrated patch of a hydrogel-plasma generator capable of carrying active species and / or useful substances according to one embodiment of the present invention.

[0066] Although not limited thereto, when the dielectric layer (12) is composed of a flexible dielectric, it may be composed of a material selected from the group consisting of high molecular polymer, flexible glass, fabric, and paper.

[0067] Although not limited thereto, the high molecular polymer may be selected from the group consisting of polyimide (PI), polyethylene terephthalate (PET), polycarbonate (PC), polyethylene (PE), polyurethane (PU), polymethyl methacrylate (PMMA), polystyrene (PS), polytetrafluoroethylene (PTFE), and mixtures thereof. Although not limited thereto, the high molecular polymer may be suitable for polyimide in terms of strength, processability, and insulation.

[0068] Although not limited thereto, the dielectric layer (12) is composed of an insulating film surrounding the lower surface and side surface of the voltage-applying electrode and an insulating film formed on the upper surface of the voltage-applying electrode, thereby surrounding the voltage-applying electrode, thereby preventing arcing between the voltage-applying electrode and the grounding electrode.

[0069]

[0070] The first electrode (14) and the second electrode (16) may both be voltage-applying electrodes, and the first electrode (14) may be a ground electrode and the second electrode (16) may be a voltage-applying electrode. That is, the first electrode (14) and the second electrode (16) may both be configured to be connected to a power source or to be connected to a power source and a ground source, respectively.

[0071] Although not limited thereto, the first electrode (14) may be a ground electrode and the second electrode (16) may be a voltage application electrode.

[0072] Although not limited thereto, the plasma generating device (10) is characterized in that at least one of the first electrode (14) and the second electrode (16) is arranged in a certain pattern. That is, only one of the first electrode (14) and the second electrode (16) may be patterned, or both the first electrode (14) and the second electrode (16) may be patterned. According to the above configuration, the plasma generation efficiency can be improved and the contact surface can be maximized when treating skin diseases, wounds, etc. Although not limited thereto, a case where the first electrode (14) is a patterned ground electrode and the second electrode (16) is a flat voltage application electrode can be advantageous in terms of inducing a synergistic antimicrobial effect and manufacturing productivity.

[0073] Although not limited thereto, the plasma generating device (10) can be easily formed in various patterns, such as a hexagonal honeycomb pattern, inside a frame of various shapes. That is, the plasma generating device (10) of the present invention can be connected in a free patterning without being restricted to a specific direction, and can be easily formed in a repeating pattern, such as a circle, triangle, square, hexagon, octagon, star shape, etc., inside the frame using a conventional known technology. Although not limited thereto, for example, the repeating pattern can be formed by an etching method using a mask pattern similar to a known method for manufacturing a PCB substrate.

[0074] Although not limited thereto, the first electrode (14) and the second electrode (16) may be made of gold, silver, titanium, cobalt, chromium, copper, aluminum, stainless steel, and alloys thereof, and when used in contact with the human body, biocompatible metals such as gold, silver, titanium, cobalt, and chromium may be more suitable.

[0075]

[0076] Although not limited thereto, the ground electrode (first electrode (14) in the case of FIG. 1) of the plasma generator (10) may be configured to come into contact with the target object to maximize the synergistic antimicrobial effect.

[0077]

[0078] Although not limited thereto, in order to use a large-area discharge in the form of an electric discharge in the plasma generating device (10) of the present invention, a surface dielectric barrier discharge (SDBD) may be most suitable. Using the surface dielectric barrier discharge has the advantage of being able to obtain a high concentration of active species per unit volume of the discharge area within a controllable range.

[0079]

[0080] Although not limited thereto, the plasma generator (10) in the present invention may be a low-temperature atmospheric pressure plasma generator that operates by a low-frequency power source. According to the above-described configuration, the plasma generator (10) is safe even when applied to the human body, and the reliability, safety, and durability of the plasma generator (10) can be improved through dielectric protection.

[0081] Although not limited thereto, the frequency applied to the plasma generator (10) may be suitable for efficient generation of air surface dielectric barrier discharge, prevention of excessive heat generation, release of useful substances, and dielectric protection when 60 Hz to 35 kHz is applied, and 1 to 35 kHz may be more suitable, 5 to 35 kHz may be even more suitable, and 10 to 30 kHz may be even more suitable. If the frequency is less than 60 Hz, power generation may be complicated and the antimicrobial effect may be insufficient due to insufficient air surface dielectric barrier discharge, and if it exceeds 35 kHz, heat generation may be severe, which may cause destruction of internal elements such as dielectrics.

[0082] Although not limited thereto, the voltage applied to the plasma generator (10) may be suitable in terms of dielectric protection, release of useful substances, and antimicrobial effect when the voltage is 1 to 5 kV, and may be more suitable when the voltage is 2 to 5 kV.

[0083] Although not limited thereto, the plasma generator (10) can generate numerous substances that act as purifiers, such as OH radicals, oxygen anions, hydrogen peroxide, electrons, and ultraviolet rays, by the plasma (P in FIG. 1) generated on both sides of the patterned first electrode (14). Although not limited thereto, when dielectric barrier discharge is used for large-area application, microorganisms can be sterilized or inactivated by OH radicals and ozone, and in addition, volatile organic compounds (VOCs) such as aldehydes, ketones, ammonia, hydrogen sulfide, and nitrogen compounds can also be directly decomposed through plasma. In particular, the plasma generator (10) can generate a large amount of ozone and hydroxyl active species, which are oxygen active species that inactivate viruses.

[0084]

[0085] FIG. 3 is a photograph showing a hydrogel capable of carrying an active species and / or a useful substance, which is provided in a patch integrated with a hydrogel-plasma generator capable of carrying an active species and / or a useful substance according to one embodiment of the present invention.

[0086] The hydrogel (20) above has no particular limitations as long as it can support active species and / or useful substances generated by the plasma generator (10). Any known hydrogel can be used. The thickness and shape of the hydrogel (20) can be adjusted as needed, such as in a film form.

[0087]

[0088] Although not limited thereto, the hydrogel (20) may be provided to be detachably attached to the body portion (1). According to the above-described configuration, the hydrogel (20) can be separated when necessary to replace and contain the necessary useful substance, or can be replaced with a hydrogel (20) containing the necessary useful substance. Therefore, when treatment of various useful substances is required, the treatment effect on the target object can be maximized by replacing the useful substances contained in the hydrogel (20).

[0089] The useful substance loaded in the hydrogel (20) may be appropriately employed depending on the condition of the subject to be treated. Although not limited thereto, the useful substance may have one or more activities selected from antibacterial, anticancer, antiviral, and skin beauty. Although not limited thereto, the useful substance may be one or more selected from plant extracts, physiologically active substances, anticancer agents, and vaccines. Although not limited thereto, the physiologically active substance may be one or more selected from caffeic acid, anomalin, adonitol, flavonoid, saponin, rutin, glutamic acid, quercetin, and astaxanthin. Although not limited thereto, the plant extract may be one or more water or alcohol extracts selected from tangerine peel, green tea, safflower, green tea, Schisandra chinensis, Poria cocos, wolfberry, raw white bark, roundworm, white worm, magnolia berry, hazelnut fruit, frankincense, mulberry bark, persimmon leaf, propolis, calendula, buchu, honey, sophora lanceolata, and centella asiatica. Although not limited thereto, the anticancer agent may be one or more selected from decarbazine, cisplatin, vinblastine, taxol, and anti-programmed death-1 enzyme. Although not limited thereto, the vaccine may be one or more killed vaccines selected from influenza, cholera, and measles vaccines.

[0090]

[0091] Although not limited thereto, the hydrogel (20) may be provided while maintaining a certain distance from the plasma generator (10). According to the above configuration, when the plasma generator (10) is driven, a discharge space is formed, so that discharge efficiency can be improved without a separate spacer.

[0092]

[0093] Although not limited thereto, openings may be provided on both sides of the body portion (1), and the hydrogel (20) may be provided on both sides of the plasma generating device (10). According to the above configuration, different useful substances may be impregnated in the hydrogel (20) with one patch, and thus it may be used for various purposes.

[0094]

[0095] While the detailed description herein has described specific embodiments, it should be understood that various modifications are possible without departing from the scope of the present disclosure. Therefore, the scope of the present disclosure is not limited to the described embodiments, but should be determined by the claims and their equivalents.

[0096]

[0097] [Explanation of symbols]

[0098] 1: Body

[0099] 1a: First landing home

[0100] 1b: Second landing home

[0101] 1c: Opening

[0102] 10: Plasma generator

[0103] 12: Dielectric layer

[0104] 14: First electrode

[0105] 16: Second electrode

[0106] 20: Hydrogel

Claims

1. A body portion having an opening on at least one side; A plasma generating device provided inside the above body portion; and A hydrogel-plasma generator integrated patch comprising a hydrogel, which is provided on at least one side of the plasma generator and on the open side of the body, and which carries at least one of an active species and a useful substance.

2. In paragraph 1, A hydrogel-plasma generator integrated patch that controls the amount of plasma generated from the plasma generator to control the release amount of a useful substance contained in the hydrogel.

3. In paragraph 1, A hydrogel-plasma generator integrated patch capable of loading one or more active oxygen species and nitrogen species into the hydrogel by driving the plasma generator, and then stopping the operation of the plasma generator and treating the loaded one or more active oxygen species and nitrogen species onto the skin.

4. In paragraph 1, A hydrogel-plasma generator integrated patch that induces the treatment of skin diseases and antimicrobial action of one or more types of active oxygen species and nitrogen species by plasma generated from the plasma generator and a useful substance contained in the hydrogel.

5. In paragraph 1, A patch integrated with a hydrogel-plasma generator, wherein the opening of the above body part is provided to be openable.

6. In paragraph 1, A hydrogel-plasma generator integrated patch, wherein a mounting portion for mounting the plasma generator is provided on the inside of the body portion.

7. In paragraph 1, The above plasma generator dielectric layer; A first electrode formed on one side of the dielectric layer; Including a second electrode formed on the other side of the dielectric layer, A hydrogel-plasma generator integrated patch, wherein at least one of the first electrode and the second electrode is arranged in a certain pattern.

8. In paragraph 1, The above plasma generator is a low-temperature atmospheric pressure plasma generator operated by a low-frequency power source, and is a hydrogel-plasma generator integrated patch.

9. In paragraph 1, The above hydrogel is a hydrogel-plasma generator integrated patch that is provided so that it can be attached and detached to the body part.

10. In paragraph 1, A hydrogel-plasma generator integrated patch, wherein the hydrogel is provided at a certain distance from the plasma generator.

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