Reaction apparatus for light-driven reaction

Abstract

Provided is a reaction apparatus for a light-driven reaction, comprising a cover plate (1), a reaction plate (2), and a bottom plate (3) which are disposed in sequence. The reaction plate (2) is provided with placement units and an illumination structure. A plurality of placement units are sequentially arranged side by side on the reaction plate (2), each placement unit comprising a plurality of placement holes (5) which are sequentially arranged and penetrate through the reaction plate (2), and each placement hole (5) being provided with a reaction vial. The illumination structure comprises clamping recesses (8), a light source, and a power connection port (6). A plurality of clamping recesses (8) are arranged in one-to-one correspondence with the placement units, and each clamping recess (8) is in communication with the placement holes (5) within the corresponding placement unit. The light source is arranged within a clamping recess (8) and is used for providing light to the placement holes (5). The power connection port (6) is arranged on the reaction plate (2) and is electrically connected to the light source. The provided reaction apparatus can provide illumination conditions for a light-driven chemical reaction, and does not have disadvantages such as obstructed light paths or difficulty in uniformly mixing a reaction system.

Description

A reaction device for light-driven reaction

[0001] Cross-references to related applications

[0002] This application claims priority to Chinese Patent Application No. 202410988190.6, filed on July 23, 2024, entitled "A Reaction Device for a Photo-Driven Reaction," and Chinese Patent Application No. 202421745361.4, filed on July 23, 2024, entitled "A Reaction Device for a Photo-Driven Reaction," the entire contents of which are incorporated herein by reference. Technical Field

[0003] This application relates to the field of chemical reaction equipment technology, and in particular to a reaction device for light-driven reactions. Background Technology

[0004] High-throughput chemistry is a chemical research method that utilizes automated equipment and high-throughput technology to rapidly and efficiently perform large-scale chemical reactions and compound synthesis. The goal of high-throughput chemistry is to accelerate the discovery and optimization of new compounds, as well as to speed up drug screening and materials development by simultaneously processing multiple reaction conditions and compound samples. Reaction plates are crucial reaction equipment in realizing automated high-throughput chemistry processes.

[0005] Reaction plates, also known as drop plates or well plates, are a common tool in laboratories, mainly used for chemical or biochemical experiments. When light-driven chemical reactions are required, reaction plates that can provide light are needed. The most common type is the bottom-illuminated photochemical reaction device. However, this type of device has disadvantages such as poor light path and difficulty in mixing the reaction system.

[0006] In summary, there is an urgent need for a reaction device for light-driven reactions to solve the problems existing in related technologies.

[0007] Summary of the Invention

[0008] To address the aforementioned issues, this application discloses a reaction apparatus for a light-driven reaction, comprising a cover plate, a reaction plate, and a base plate arranged sequentially.

[0009] The reaction plate is provided with placement units and a lighting structure; several placement units are arranged side by side on the reaction plate, and each placement unit includes several placement holes arranged in sequence and penetrating the reaction plate, with a reaction bottle placed in each placement hole; the lighting structure includes slots, a light source, and a power connection port, with several slots corresponding one-to-one with the placement units and the slots communicating with the placement holes in the corresponding placement units, the light source being placed in the slots to provide light to the placement holes, and the power connection port being placed on the reaction plate and electrically connected to the light source.

[0010] Optionally, the light source is a lamp board, which is provided with lamp beads that match the number of placement holes in a single placement unit, with each lamp bead corresponding to a placement hole.

[0011] Optionally, the lamp board is provided with at least two different wavelengths and at least two different light emission angles of lamp beads; the lamp beads include one or two of LED lamp beads and laser lamp beads.

[0012] Optionally, the wavelength of the lamp bead includes one or more of 278nm, 365nm, 395nm, 450nm, 520nm, 560nm, 590nm, 630nm, 670nm, 730nm, 808nm, and white light; the emission angle of the lamp bead includes one or more of 15°, 30°, 45°, 60°, 90°, and 120°.

[0013] Optionally, one end of the card slot is a through slot, and a notch is provided at the opening of the through slot.

[0014] Optionally, the base plate is provided with a fluid channel for communicating with external fluid.

[0015] Optionally, a flexible layer is also provided between the cover plate and the reaction plate.

[0016] Optionally, the flexible layer is provided with bosses that correspond one-to-one with the holes on the reaction plate, and the height of the bosses is 2-5mm.

[0017] Optionally, the flexible layer may be made of one of the following materials: silicone, rubber, fluoropolymer, and latex.

[0018] Optionally, the cover plate, reaction plate, and base plate are made of aluminum alloy, magnesium alloy, or copper.

[0019] Optionally, the placement unit is provided in four groups.

[0020] Optionally, the placement hole is provided with twelve holes.

[0021] Optionally, the fluid channel includes a set of longitudinal pipes and two sets of transverse pipes.

[0022] Optionally, the fluid channel includes multiple sets of longitudinal pipes and multiple sets of transverse pipes.

[0023] Optionally, a single set of longitudinal piping or a single set of transverse piping may comprise four pipes.

[0024] Optionally, the first and last ends of one set of longitudinal pipelines are respectively connected to one end of the other two sets of transverse pipelines, and one end of the longitudinal pipeline has a blind hole left during drilling.

[0025] Optionally, the ends of the two sets of transverse pipes away from the longitudinal pipes have blind holes left during drilling.

[0026] Optionally, holes may be drilled along the longitudinal direction of the transverse conduit to connect the four pipes of a single set of transverse conduits and leave blind holes.

[0027] Optionally, it also includes thermocouples mounted on the reaction plate.

[0028] Optionally, it also includes a clamping groove disposed on the reaction plate.

[0029] The advantages of this application compared to related technologies are as follows:

[0030] (1) The reaction device obtained by the technical solution of this application has a light-illuminating structure, which can provide light conditions for light-driven chemical reactions. Compared with the existing transparent reaction plates, the reaction device provided by this application does not have the disadvantages of poor light path and difficulty in mixing the reaction system. In the reaction device, the reaction bottle is a separate component, and the appropriate material can be replaced according to the different reaction types to resist chemical corrosion. When the reaction bottle is damaged, only the damaged reaction bottle can be replaced, which helps to reduce the waste of experimental consumables and reduce the cost of experiments. Thus, it better solves the technical problems existing in related fields and is conducive to promoting the application of high-throughput chemistry in light-driven chemical reactions.

[0031] (2) Through the technical solution of this application, the temperature of the external fluid can be controlled so that the temperature of the bottom plate is changed when the fluid flows through the fluid channel. Since the materials of the cover plate, reaction plate and bottom plate are all metal (such as aluminum alloy, magnesium alloy or copper, etc.), they have good thermal conductivity. When the temperature of the bottom plate changes, it can simultaneously drive the temperature of the reaction plate and other components to change, so that the reaction bottle is in a relatively stable temperature environment, avoiding the influence of temperature changes caused by light on the ongoing chemical reaction in the reaction bottle, ensuring the consistency of experimental conditions, and improving the accuracy and reliability of experimental results.

[0032] (3) Through the technical solution of this application, when the reaction bottle is loaded into the reaction plate, the bottle mouth is sealed by pressing the cover plate and the flexible layer tightly onto the reaction plate, thereby forming a separate sealed reaction environment in each reaction bottle, avoiding the risk of cross-contamination or the experimental results-reaction data deviation caused by sample evaporation and edge effect; on this basis, protrusions corresponding to the holes on the reaction plate can be set on the flexible layer to further enhance the sealing performance of the reaction bottle.

[0033] (4) Through the technical solution of this application, the flexible layer is made of elastic materials such as silicone, rubber and latex, which can adapt to the large pressure of the cover plate or bottom plate, and can also adapt to the deformation of the shape of the reaction bottle mouth to avoid crushing the reaction bottle; on this basis, chemical corrosion resistant materials such as fluoropolymer can also be used.

[0034] (5) By using the technical solution of this application, aluminum alloy, magnesium alloy or copper or other metals or alloys as materials for making the cover plate, reaction plate body and base plate, the good thermal conductivity of these materials can be used to improve the uniformity of the overall temperature when the temperature of the reaction plate is controlled by fluid, and avoid local temperature being too high or too low.

[0035] The preferred embodiments of this application will be described in more detail below with reference to the accompanying drawings, so as to facilitate an understanding of the features and advantages of this application. Attached Figure Description

[0036] To more clearly illustrate the technical solutions in the embodiments of this application, the accompanying drawings used in the description of the embodiments will be briefly introduced below. Obviously, the accompanying drawings described below are only some embodiments of this application. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0037] Figure 1 is an explosion schematic diagram of the reaction device according to an embodiment of this application.

[0038] Figure 2 is a schematic diagram of the structure of the reaction plate in the reaction device of this application embodiment.

[0039] Figure 3 is a schematic diagram of the reaction plate in Figure 2 from another angle.

[0040] Figure 4 is a schematic diagram of the structure of the bottom plate in the reaction device of this application embodiment.

[0041] Figure 5 is a structural schematic diagram of the base plate from another angle in Figure 4.

[0042] Figure 6 is a cross-sectional view of the base plate along surface AA in Figure 5.

[0043] Among them, 1-cover plate, 2-reaction plate, 3-bottom plate, 4-flexible layer, 5-placement hole, 6-electrical connection port, 7-notch, 8-slot, 9-fluid channel, 10-thermocouple. Detailed Implementation

[0044] It should be noted that, unless otherwise specified, the embodiments and features described in this application can be combined with each other. The application will be further described in detail below with reference to the accompanying drawings and specific embodiments.

[0045] In the embodiments of this application, directional indicators such as up, down, left, right, front, back, etc. are only used to explain the relative positional relationship and movement of the components in a specific posture as shown in the attached figure. If the specific posture changes, the directional indicator will also change accordingly.

[0046] Furthermore, the use of terms such as "first" and "second" in this application is for descriptive purposes only and should not be construed as indicating or implying their relative importance or implicitly specifying the number of technical features indicated. Therefore, a feature defined with "first" or "second" may explicitly or implicitly include at least one of those features.

[0047] Please refer to Figure 1. This application embodiment provides a reaction device for a light-driven reaction, including a cover plate 1, a reaction plate 2 and a base plate 3 arranged in sequence, which are bolted together.

[0048] Referring to Figures 2 and 3, the reaction plate 2 is provided with placement units and an illumination structure. Four sets of placement units are arranged side by side on the reaction plate 2. Each placement unit includes twelve placement holes 5 arranged in sequence and penetrating the reaction plate. Each placement hole 5 is used to hold a reaction bottle. The illumination structure includes slots 8, a light source, and a power connection port 6. The four slots are arranged one-to-one with the four sets of placement units, and the slots are connected to the placement holes 5 in the corresponding placement units (as shown in Figure 3, one slot corresponds to one set of placement units, and the twelve placement holes in the placement unit are connected to the slots respectively). The light source is set in the slot to provide light to the placement holes (i.e., to provide illumination from the hole wall direction, rather than from the bottom, avoiding the light path obstruction caused by the need for magnetic stirring in the reaction system or by precipitation in the reaction system. Therefore, magnetic stirring can also be used in the light-driven reaction system, effectively avoiding the problem of difficulty in mixing the reaction system in related fields). The power connection port 6 is set on the reaction plate 2 and electrically connected to the light source (the power connection port type includes Mini). USB interface (mini USB, a USB interface standard; USB is an abbreviation for Universal Serial Bus, a technology developed for transferring data between PCs and digital devices), Type-C interface (common fast charging interface), etc.).

[0049] Optionally, in this embodiment, the light source is a lamp board, and the lamp board is provided with lamp beads that match the number of placement holes 5 in a single placement unit, with each lamp bead corresponding to a placement hole.

[0050] Optionally, the lamp board is provided with at least two different wavelengths of lamp beads and at least two different light emission angles of lamp beads. Optionally, the lamp beads are LED lamp beads.

[0051] Optionally, the wavelength of the LED bead includes 365nm and 520nm; the light emission angle of the LED bead includes 45° and 60°.

[0052] Optionally, one end of the slot 8 is a through slot, and a notch 7 is provided at the opening of the through slot. When the lamp board in the slot needs to be repaired or replaced, the lamp board can be more easily removed from the slot through the notch.

[0053] Optionally, referring to Figures 4, 5, and 6, the base plate 3 is provided with a fluid channel 9 for communicating with external fluid. Referring to Figure 6, the fluid channel includes a set of longitudinal pipes and two sets of transverse pipes (in some embodiments, multiple sets of longitudinal and transverse pipes may also be provided). Each set of longitudinal or transverse pipes includes four pipes. The first and last ends of the set of longitudinal pipes are respectively connected to one end of the other two sets of transverse pipes, and one end of the longitudinal pipe has a blind hole left during drilling. The ends of the two sets of transverse pipes away from the longitudinal pipes also have blind holes left during drilling. Drilling is also performed along the longitudinal direction of the transverse pipes to connect the four pipes of the single set of transverse pipes, leaving blind holes. By sealing the blind holes and two pipe openings in the two sets of transverse pipes with rubber plugs or sealing screws, the cooling medium flows through the fluid channel in the direction shown by the arrow in Figure 6. This pipe design effectively improves the heat exchange efficiency of the external cooling medium flowing through the fluid channel of the base plate.

[0054] Optionally, a flexible layer 4 is also provided between the cover plate 1 and the reaction plate 2.

[0055] Optionally, the flexible layer 4 is provided with bosses that correspond one-to-one with the placement holes on the reaction plate 2, and the height of the bosses is 2mm.

[0056] Optionally, the flexible layer 4 may be made of one of the following materials: silicone, rubber, fluoropolymer, and latex (silicone is used in this embodiment).

[0057] Optionally, the cover plate 1, reaction plate 2, and base plate 3 are made of aluminum alloy, magnesium alloy, or copper (aluminum alloy is used in this embodiment).

[0058] Optionally, the system also includes a thermocouple 10 disposed on the reaction plate. The thermocouple is inserted into the reaction plate through pre-drilled holes in the cover plate and the flexible layer to monitor the temperature changes of the reaction plate in real time.

[0059] Optionally, it also includes a clamping groove disposed on the reaction plate. The shape of the clamping groove matches that of automated clamping devices such as grippers, facilitating clamping by such devices.

[0060] The present application has been further described above with reference to specific embodiments. However, it should be understood that the specific descriptions herein should not be construed as limiting the substance and scope of the present application. Various modifications made by those skilled in the art to the above embodiments after reading this specification are all within the scope of protection of the present application. Industrial applicability

[0061] This application provides a reaction device for light-driven reactions, which does not have the disadvantages of poor light path and difficulty in mixing the reaction system, and is conducive to promoting the application of high-throughput technology in light-driven chemical reactions.

[0062] Furthermore, it is understood that the reaction apparatus for light-driven reactions of this application is reproducible and can be widely applied in the field of chemical reaction equipment technology.

Claims

1. A reaction device for photo-driven reactions, characterized in that, The cover plate (1), the reaction plate (2) and the bottom plate (3) are sequentially arranged. The reaction plate (2) is provided with a placing unit and a light structure; a plurality of placing units are sequentially and side by side arranged on the reaction plate, the placing unit comprises a plurality of placing holes (5) sequentially arranged and penetrating through the reaction plate, the placing hole (5) is provided with a reaction bottle; the light structure comprises a clamping groove (8), a light source and an electrical connection port (6), the clamping groove (8) is provided one by one with the placing unit and the clamping groove is communicated with the placing hole (5) in the corresponding placing unit, the light source is arranged in the clamping groove to provide light for the placing hole, and the electrical connection port (6) is arranged on the reaction plate and electrically connected with the light source.

2. The reaction apparatus according to claim 1, wherein The light source is a lamp panel, and a plurality of lamp beads matched with the number of placing holes in a group of placing units are arranged on the lamp panel.

3. The reaction apparatus of claim 2, wherein The lamp panel is provided with at least two kinds of lamp beads with different wavelengths and at least two kinds of lamp beads with different light emitting angles; the lamp beads include one or both of LED lamp beads and laser lamp beads.

4. The reaction apparatus of claim 3, wherein The wavelength of the lamp bead includes one or more of 278nm, 365nm, 395nm, 450nm, 520nm, 560nm, 590nm, 630nm, 670nm, 730nm, 808nm and white light; the light emitting angle of the lamp bead includes one or more of 15°, 30°, 45°, 60°, 90° and 120°.

5. The reaction apparatus of claim 1, wherein One end of the clamping groove is a through groove, and a notch (7) is arranged at the opening of the through groove.

6. The reaction apparatus of claim 1, wherein The bottom plate (3) is provided with a fluid channel (9) for communicating with the outside.

7. The reaction apparatus of claim 1, wherein The cover plate (1) and the reaction plate (2) are further provided with a flexible layer (4).

8. The reaction apparatus of claim 7, wherein The flexible layer (4) is provided with a boss corresponding to the placing hole on the reaction plate (2), and the height of the boss is 2-5mm.

9. The reaction apparatus of claim 8, wherein The material of the flexible layer (4) includes one of silica gel, rubber, fluorine glue and latex.

10. The reactor of any of claims 1-9, wherein, The materials of the cover plate (1), the reaction plate (2) and the bottom plate (3) are aluminum alloy, magnesium alloy or copper.

11. The reactor of any of claims 1-10, wherein The placing unit is provided with four groups.

12. The reactor of any of claims 1-11, wherein, The placing hole is provided with twelve.

13. The reaction apparatus of claim 6, wherein The fluid channel includes a group of longitudinal pipelines and two groups of transverse pipelines.

14. The reaction apparatus of claim 6, wherein The fluid channel includes a plurality of groups of longitudinal pipelines and a plurality of groups of transverse pipelines.

15. The reaction apparatus according to claim 13 or 14, characterized by A group of longitudinal pipelines or a group of transverse pipelines includes four pipes.

16. The reaction apparatus of claim 15, wherein The first and last ends of a group of longitudinal pipelines are respectively communicated with the other two groups of transverse pipelines, and one end of the longitudinal pipeline has a blind hole left by drilling.

17. The reaction apparatus of claim 16, wherein The ends of the two groups of transverse pipelines away from the longitudinal pipeline have blind holes left by drilling.

18. The reaction apparatus of claim 17, wherein The longitudinal of the transverse pipeline is also drilled to communicate the four pipes of a group of transverse pipelines and leave a blind hole.

19. The reactor of any of claims 1-18, wherein It also includes a thermocouple arranged on the reaction plate, which is inserted into the reaction plate through the reserved hole of the cover plate and the flexible layer.

20. The reactor of any of claims 1-19, wherein, It also includes a clamping groove arranged on the reaction plate.

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