Use of composition containing long-chain acyl alanine for enhancing hair fluffiness and / or repairing hair cuticles and / or preventing hair breakage

Abstract

Use of a composition containing long-chain acyl alanine for enhancing hair fluffiness and / or repairing hair cuticles and / or preventing hair breakage, and a non-therapeutic cosmetic method. A cosmetic composition containing long-chain acyl alanine.

Description

Use of long chain acylalanine-containing compositions to enhance hair volume and / or repair hair cuticles and / or prevent hair breakage TECHNICAL FIELD

[0001] The present invention relates to the field of hair care, in particular to long chain acylalanine-containing compositions for use in enhancing hair volume and / or repairing hair cuticles and / or preventing hair breakage. BACKGROUND

[0002] Hair can be damaged and weakened by external atmospheric factors such as pollution and inclement weather, and also by mechanical or chemical treatments or certain daily practices such as brushing, combing, dyeing, bleaching, permanent waving, straightening and / or repeated washing. Hair can thus end up damaged and can become dry, rough, fragile, dull, split and / or fine and limp over time.

[0003] Each hair has many uneven cuticles on its surface, and the above-mentioned mechanical or chemical treatments or daily practices such as dyeing and perming can damage the structure of the hair fibers, causing damage to the cortex, and the loss of nutrients inside the hair after dyeing and perming without timely care, which cannot guarantee the supply of nutrients to the hair, and the damaged cuticles will curl up, increasing the friction between the hair, causing the hair to tangle together, and more friction exacerbates the damage to the cuticles, which cannot be repaired for a long time, causing the loss of nutrients inside the cortex, and the hair becomes dry, rough, prone to knotting, dull and dark, and the ends split (CN114699340A).

[0004] Volume is a description of hair that looks very layered, with gaps, rather than close, collapsed. The above-mentioned daily practices such as dyeing and perming can cause damage to the hair, making it rough and losing its luster, thereby reducing the smoothness and flexibility, and making it difficult to style the hair due to the increase in friction, and in addition to the problems of broken hair or split ends, the hair also becomes fine and loses elasticity, leading to a loss of vitality and drooping, thereby causing a loss of volume.

[0005] The above-mentioned problems of hair are usually improved by various conditioning agents, efficacy ingredients. CN113226270B discloses the application of a composition comprising at least one carnitine salt or carnitine derivative salt comprising an aromatic organic anion, EP0978272 discloses the use of specific organic acids to care for and / or repair keratin fibers. CN111163754B discloses an efficacy ingredient comprising a hydrophobic polymer and a polyquaternium-11.

[0006] However, the existing various conditioning agents, efficacy ingredients still have various problems such as high price, insufficient safety, limited effect, etc., and new solutions are still needed. SUMMARY

[0007] The present application aims to provide a composition capable of enhancing the hair bulkiness and / or repairing the hair cuticle and / or preventing the hair breakage, which is remarkably effective and also very safe without side effects.

[0008] Specifically, the present application is as follows.

[0009] [1] Use of a composition containing N-long chain acyl alanine and / or a salt thereof for increasing the hair breakage resistance.

[0010] [2] Use of a composition containing N-long chain acyl alanine and / or a salt thereof for increasing the hair bulkiness.

[0011] [3] Use of a composition containing N-long chain acyl alanine and / or a salt thereof for repairing the hair cuticle.

[0012] [4] The use according to any one of [1] to [3], wherein the composition is a composition for topical application.

[0013] [5] The use according to any one of [1] to [3], wherein the composition is a cosmetic composition, preferably a hair care composition.

[0014] [6] The use according to any one of [1] to [5], wherein the weight percentage content of N-long chain acyl alanine and / or a salt thereof in the composition is 1% or more, preferably 2% or more, more preferably 3% or more.

[0015] [7] The use according to any one of [1] to [6], wherein the composition contains N-long chain acyl alanine and a basic amino acid, or contains a salt of N-long chain acyl alanine with a basic amino acid.

[0016] [8] The use according to any one of [1] to [6], wherein the composition contains a sodium salt, a potassium salt or an ammonium salt of N-long chain acyl alanine.

[0017] [9] The use according to any one of [1] to [8], wherein the N-long chain acyl group of N-long chain acyl alanine is derived from a saturated or unsaturated linear or branched fatty acid having 8 to 22 carbon atoms; preferably, the N-long chain acyl group is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, palm oil fatty acyl.

[0018]

[0010] . Use according to [9], the N-long chain acyl alanine is selected from one or more of N-octanoyl-L-alanine, N-decanoyl-L-alanine, N-undecanoyl-L-alanine, N-lauroyl-L-alanine, N-myristoyl-L-alanine, N-pentadecanoyl-L-alanine, N-palmitoyl-L-alanine, N-stearoyl-L-alanine, N-isostearoyl-L-alanine, N-oleoyl-L-alanine, N-linoleoyl-L-alanine, preferably N-lauroyl-L-alanine.

[0019]

[0011] . Use according to [7], the basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, diaminopropionic acid, preferably arginine and / or lysine, most preferably L-arginine.

[0020]

[0012] . A method of preventing hair breakage comprising: i) the step of applying to the hair a composition comprising N-long chain acyl alanine and / or a salt thereof; ii) the step of leaving the composition on the hair; iii) the step of rinsing and / or washing the hair.

[0021]

[0013] . A method of increasing hair volume comprising: i) the step of applying to the hair a composition comprising N-long chain acyl alanine and / or a salt thereof; ii) the step of leaving the composition on the hair; iii) the step of rinsing and / or washing the hair.

[0022]

[0014] . A method of repairing hair cuticles comprising: i) the step of applying to the hair a composition comprising N-long chain acyl alanine and / or a salt thereof; ii) the step of leaving the composition on the hair; iii) the step of rinsing and / or washing the hair.

[0023]

[0015] . The method according to any one of

[0012] to

[0014] , the weight percent content of N-long chain acyl alanine and / or a salt thereof in the composition is 1% or more, preferably 2% or more, more preferably 3% or more.

[0024]

[0016] . The method according to any one of

[0012] to

[0015] , the composition comprises N-long chain acyl alanine and a basic amino acid, or comprises a salt of N-long chain acyl alanine with a basic amino acid, or comprises a sodium / potassium / ammonium salt of N-long chain acyl alanine.

[0025]

[0017] . The method according to any one of

[0012] to

[0016] , the N-long chain acyl alanine is selected from one or more of N-octanoyl-L-alanine, N-decanoyl-L-alanine, N-undecanoyl-L-alanine, N-lauroyl-L-alanine, N-myristoyl-L-alanine, N-pentadecanoyl-L-alanine, N-palmitoyl-L-alanine, N-stearoyl-L-alanine, N-isostearoyl-L-alanine, N-oleoyl-L-alanine, N-linoleoyl-L-alanine, preferably N-lauroyl-L-alanine; the basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, diaminopropionic acid, preferably L-arginine.

[0026]

[0018] . A cleansing composition having an effect of enhancing hair fluffiness, the composition comprising an N-long chain acyl alanine and a basic amino acid; the weight percentage content of the N-long chain acyl alanine in the composition is 2% or more, preferably 4% or more; the weight percentage content of the basic amino acid in the composition is 1% or more, preferably 2% or more; the composition is free of or substantially free of a sulfate surfactant, an ethoxylate surfactant, and a fatty acid salt surfactant.

[0027]

[0019] . A cleansing composition having an effect of repairing hair cuticle, the composition comprising an N-long chain acyl alanine and a basic amino acid; the weight percentage content of the N-long chain acyl alanine in the composition is 2% or more, preferably 4% or more; the weight percentage content of the basic amino acid in the composition is 1% or more, preferably 2% or more; the composition is free of or substantially free of a sulfate surfactant, an ethoxylate surfactant, and a fatty acid salt surfactant.

[0028]

[0020] . A cleansing composition having an effect of preventing hair breakage, the composition comprising an N-long chain acyl alanine and a basic amino acid; the weight percentage content of the N-long chain acyl alanine in the composition is 2% or more, preferably 4% or more; the weight percentage content of the basic amino acid in the composition is 1% or more, preferably 2% or more; the composition is free of or substantially free of a sulfate surfactant, an ethoxylate surfactant, and a fatty acid salt surfactant.

[0029]

[0021] . The cleansing composition according to any one of

[0018] to

[0020] , the N-long chain acyl alanine is selected from one or more of N-octanoyl-L-alanine, N-decanoyl-L-alanine, N-undecanoyl-L-alanine, N-lauroyl-L-alanine, N-myristoyl-L-alanine, N-pentadecanoyl-L-alanine, N-palmitoyl-L-alanine, N-stearoyl-L-alanine, N-isostearoyl-L-alanine, N-oleoyl-L-alanine, N-linoleoyl-L-alanine, preferably N-lauroyl-L-alanine; the basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, diaminopropionic acid, preferably L-arginine.

[0030]

[0022] . A non-therapeutic cosmetic method comprising topically applying to the hair a cosmetic composition for enhancing hair fluffiness, the cosmetic composition comprising an N-long chain acyl alanine and / or a salt thereof.

[0031]

[0023] . A non-therapeutic cosmetic method comprising topically applying to the hair a cosmetic composition for repairing hair cuticles, the cosmetic composition comprising an N-long chain acyl alanine and / or a salt thereof.

[0032]

[0024] . A non-therapeutic cosmetic method comprising topically applying to the hair a cosmetic composition for preventing hair breakage, the cosmetic composition comprising an N-long chain acyl alanine and / or a salt thereof.

[0033]

[0025] . The method according to any one of

[0022] to

[0024] , the N-long chain acyl alanine and / or a salt thereof is present in the composition at a weight percentage of 1% or more, preferably 2% or more, more preferably 3% or more.

[0034]

[0026] . The cosmetic method according to any one of

[0022] to

[0025] , the composition comprises an N-long chain acyl alanine and a basic amino acid, or comprises a salt of an N-long chain acyl alanine with a basic amino acid, or comprises a sodium salt, a potassium salt or an ammonium salt of an N-long chain acyl alanine.

[0035]

[0027] . The cosmetic method according to any one of

[0022] to

[0026] , the N-long chain acyl alanine is selected from one or more of N-octanoyl-L-alanine, N-decanoyl-L-alanine, N-undecanoyl-L-alanine, N-lauroyl-L-alanine, N-myristoyl-L-alanine, N-pentadecanoyl-L-alanine, N-palmitoyl-L-alanine, N-stearoyl-L-alanine, N-isostearoyl-L-alanine, N-oleoyl-L-alanine, N-linoleoyl-L-alanine, preferably N-lauroyl-L-alanine; the basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, diaminopropionic acid, preferably L-arginine.

[0036] Compared with the prior art, the present application has beneficial technical effects:

[0037] 1. The present application surprisingly found that the composition comprising N-long chain acyl alanine and / or salts thereof can effectively repair hair cuticle.

[0038] 2. The present application surprisingly found that the composition comprising N-long chain acyl alanine and / or salts thereof can prevent hair breakage.

[0039] 3. The present application surprisingly found that the composition comprising N-long chain acyl alanine and / or salts thereof can enhance the hair fluffiness. BRIEF DESCRIPTION OF DRAWINGS

[0040] Figure 1 is a typical photograph of hair cuticle changes after testing using a blank group and an experimental group, wherein a1 is the blank group and a2 is the experimental group. DETAILED DESCRIPTION

[0041] In one embodiment, it relates to the use of a composition comprising N-long chain acyl alanine and / or salts thereof in increasing the hair breakage resistance.

[0042] In another embodiment, it relates to the use of a composition comprising N-long chain acyl alanine and / or salts thereof in increasing the hair fluffiness.

[0043] In another embodiment, it relates to the use of a composition comprising N-long chain acyl alanine and / or salts thereof in repairing hair cuticle.

[0044] In each embodiment, the composition is a cosmetic composition, especially a hair care composition.

[0045] The composition can be a composition for topical application. The composition can be prepared into an aqueous preparation, a paste, a liniment, a gel, a cream, a powder, an emulsion, or a spray, etc. For a specific product form, it can be, for example, a shampoo, a hair conditioner, a serum, a hair wash paste, etc. For the method of application, the composition can be applied to the hair, optionally massaged, allowed to contact the hair for a certain period of time, and then rinsed off with water.

[0046] In each embodiment, the weight percentage content of the N-long chain acyl alanine and / or a salt thereof in the composition is 1% or more. If the content is too low, the effect of enhancing the hair volume and / or repairing the hair cuticle and / or preventing the hair breakage is not sufficient. Further, the weight percentage content of the N-long chain acyl alanine and / or a salt thereof in the composition is 1%, 2%, 3%, 4%, 5%, 6% or more, and 50%, 45%, 40%, 35%, 30%, 25%, 20%, 15% or less.

[0047] For the N-long chain acyl alanine, the N-long chain acyl group in the N-long chain acyl alanine is derived from a saturated or unsaturated linear or branched fatty acid having 8 to 22 carbon atoms. Further, the N-long chain acyl group in the N-long chain acyl alanine is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, palm oil fatty acyl, preferably coconut oil fatty acyl or lauroyl, and most preferably lauroyl.

[0048] Further, the N-long chain acyl alanine is selected from one or more of N-octanoyl-L-alanine, N-decanoyl-L-alanine, N-undecanoyl-L-alanine, N-lauroyl-L-alanine, N-cocoyl-L-alanine, N-myristoyl-L-alanine, N-pentadecanoyl-L-alanine, N-palmitoyl-L-alanine, N-stearoyl-L-alanine, N-isostearoyl-L-alanine, N-oleoyl-L-alanine, N-linoleoyl-L-alanine, preferably N-lauroyl-L-alanine.

[0049] The synthesis process of the N-long chain acyl alanine can be referred to the general synthesis method of N-acyl amino acid surfactants, which is divided into direct and indirect methods. The direct synthesis method of the fatty acid raw material includes enzyme catalysis synthesis and dehydration condensation. The indirect synthesis method includes fatty acyl chloride acylation, fatty nitrile hydrolysis acylation, fatty acid anhydride acylation, amide carbonylation reaction, etc. More preferably, it is prepared by the reaction of fatty acyl chloride and the amino group of amino acid (Shotten-Baumann condensation reaction or Shotten-Baumann reaction).

[0050] A typical preparation process suitable for the present application is as follows: amino acid and sodium hydroxide are dissolved in water or a mixture of water and acetone to obtain an amino acid salt solution; then lauroyl chloride and sodium hydroxide solution are slowly added to the amino acid salt solution, the pH of the reaction system is controlled, after the addition is completed, the product is post-treated. Representative methods are disclosed in CN1798821A, US6703517B2, CN102875409B, JPH0570418A, etc.

[0051] For the post-treatment of N-long-chain acylalanine product, conventional recrystallization, water washing, drying, etc. can be used. Preferably, the post-treatment comprises the following steps: mixing N-long-chain acylalanine crude product with a solvent, optionally stirring, controlling the temperature T of the mixed system above the melting point of long-chain fatty acid and below the melting point of N-long-chain acylalanine, the solvent being water or an organic solvent or a mixed solution of water and an organic solvent; after controlling the temperature of the system, solid-liquid separation operation is performed. Related methods are disclosed by the present inventors in CN202210867760.7, PCT / CN2022 / 107270, and the relevant contents are hereby incorporated by reference.

[0052] For N-long-chain acylalanine and / or its salt, it refers to a combination of one or more of N-long-chain acylalanine, N-long-chain acylalanine salt. Among them, N-long-chain acylalanine salt is formed by N-long-chain acylalanine and a base. The base is selected from one or more of inorganic bases, organic amines, basic amino acids; the inorganic base is selected from one or more of sodium hydroxide, potassium hydroxide, sodium carbonate, potassium carbonate, preferably sodium hydroxide or potassium hydroxide; the organic amine is selected from amine, alkanolamine, etc.

[0053] For basic amino acid, it is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, diaminopropionic acid, preferably arginine and / or lysine, most preferably L-arginine.

[0054] Preferably, the base is present in an amount to neutralize N-long-chain acylalanine completely or partially, preferably the degree of neutralization is above 85% and less than or equal to 100%, more preferably the degree of neutralization is above 88% and below 96%.

[0055] In one example, the composition comprises N-long-chain acylalanine and basic amino acid, or comprises a salt formed by N-long-chain acylalanine and basic amino acid. In another example, the composition comprises sodium salt, potassium salt or ammonium salt of N-long-chain acylalanine.

[0056] In one embodiment, there is a method for preventing hair breakage, comprising: i) a step of applying to the hair a composition comprising N-long chain acyl amino acid and / or a salt thereof; ii) a step of leaving the composition on the hair; iii) a step of rinsing and / or washing the hair.

[0057] In another embodiment, there is a method for increasing hair volume, comprising: i) a step of applying to the hair a composition comprising N-long chain acyl amino acid and / or a salt thereof; ii) a step of leaving the composition on the hair; iii) a step of rinsing and / or washing the hair.

[0058] In yet another embodiment, there is a method for repairing hair cuticle, comprising: i) a step of applying to the hair a composition comprising N-long chain acyl amino acid and / or a salt thereof; ii) a step of leaving the composition on the hair; iii) a step of rinsing and / or washing the hair.

[0059] In the above embodiments, the definitions of N-long chain acyl amino acid, basic amino acid and the weight percent content of N-long chain acyl amino acid and / or a salt thereof in the composition are as defined in the foregoing embodiments and are not repeated here.

[0060] In one embodiment, there is a cleansing composition having the effect of enhancing hair volume, comprising N-long chain acyl amino acid and a basic amino acid; the weight percent content of N-long chain acyl amino acid in the composition is more than 2%; the weight percent content of the basic amino acid in the composition is more than 1%; the composition does not contain sulfate surfactant, ethoxylate surfactant and fatty acid salt surfactant.

[0061] In another embodiment, there is a cleansing composition having the effect of repairing hair cuticle, comprising N-long chain acyl amino acid and a basic amino acid; the weight percent content of N-long chain acyl amino acid in the composition is more than 2%; the weight percent content of the basic amino acid in the composition is more than 1%; the composition does not contain sulfate surfactant, ethoxylate surfactant and fatty acid salt surfactant.

[0062] In yet another embodiment, there is a cleansing composition having the effect of preventing hair breakage, comprising N-long chain acyl amino acid and a basic amino acid; the weight percent content of N-long chain acyl amino acid in the composition is more than 2%; the weight percent content of the basic amino acid in the composition is more than 1%; the composition does not contain or substantially does not contain sulfate surfactant, ethoxylate surfactant and fatty acid salt surfactant.

[0063] The "substantially free" of the present invention means that the content of the substance in the composition does not significantly affect the performance of the product. Further, "substantially free" means that the weight percentage content of the substance in the composition is less than 0.5wt%, preferably less than 0.1wt% or less than 0.01wt%, more preferably less than the detectable limit.

[0064] In the above three embodiments, the N-long chain acyl alanine, the basic amino acid refers to the definition in the aforementioned embodiments. For the component content, the weight percentage content of the N-long chain acyl alanine in the composition is preferably 3%, 4%, 5% or 6% or more, 50%, 45%, 40%, 35%, 30%, 25%, 20% or 15% or less. The weight percentage content of the basic amino acid in the composition is preferably 1.5%, 2%, 2.5% or 3% or more, 25%, 22.5%, 20%, 17.5%, 15%, 12.5%, 10% or 7.5% or less.

[0065] Sulfate surfactant: sodium lauryl sulfate (SLS), ammonium lauryl sulfate (ALS), sodium laureth sulfate (SLES) or ammonium laureth sulfate (ALES) can be listed, considering that it can cause irritation to the skin or scalp and / or cause damage to the hair fibers, therefore, the composition of the present invention is preferably substantially free of sulfate surfactant, more preferably completely free of sulfate surfactant.

[0066] Ethoxylate surfactant: typical is sodium laureth sulfate (SLES or AES), considering that it has moderate irritation, and ethoxylate surfactant contains a large amount of non-renewable carbon from ethylene oxide, and there are safety problems (the contained dioxane impurities have carcinogenicity), therefore, the composition of the present invention is preferably substantially free of ethoxylate, more preferably completely free of ethoxylate.

[0067] Fatty acid salt: laurate, myristate, palmitate, stearate can be listed, considering that the post-washing tension, dryness, tightness brought by such raw materials, the composition of the present invention is preferably substantially free of fatty acid salt, more preferably completely free of fatty acid salt.

[0068] In one embodiment, a non-therapeutic cosmetic method is involved, which comprises topically applying to the hair a cosmetic composition for enhancing the hair fluffiness, the cosmetic composition comprising N-long chain acyl alanine and / or a salt thereof.

[0069] In one embodiment, a non-therapeutic cosmetic method is involved, which comprises topically applying to the hair a cosmetic composition for repairing the hair cuticle, the cosmetic composition comprising N-long chain acyl alanine and / or a salt thereof.

[0070] In one embodiment, a non-therapeutic cosmetic method is provided, which comprises topically applying to hair a cosmetic composition comprising N-long chain acyl amino acid and / or a salt thereof for preventing hair breakage.

[0071] Further, the composition comprises N-long chain acyl amino acid and a basic amino acid, or comprises a salt of N-long chain acyl amino acid and a basic amino acid, or comprises a sodium salt, a potassium salt or an ammonium salt of N-long chain acyl amino acid. The N-long chain acyl amino acid and / or a salt thereof, the basic amino acid, and the amount of the ingredients are defined in the aforementioned embodiments, which are not repeated here.

[0072] In each of the above embodiments, the composition of the present application can optionally further comprise other ingredients such as fragrance, dye, thickening agent, humectant, chelating agent, extract, amino acid, nucleic acid, vitamin, enzyme, anti-inflammatory agent, antioxidant, ultraviolet absorber, antiperspirant, pH adjusting agent, pearl agent, etc.

[0073] In each of the embodiments, the unaddressed details, the selection of species, the selection of amount, etc. can be referred to the relevant guidance of other embodiments without conflict in content. Each of the embodiments is not repeated here for brevity.

[0074] The present application is further described in conjunction with the accompanying drawings and examples, which should be understood as merely illustrative of the present application and not limiting the scope of the present application. Furthermore, it should be understood that those skilled in the art can make various modifications or changes to the present application after reading the content of the present application, and these equivalents are also within the scope of the appended claims.

[0075] Examples

[0076] 1 Test Material

[0077] Test sample: 83.90 g of water was first added, then 10 g of lauroyl alanine was added, the solution was heated to 80-85°C, and 6.10 g of arginine was continuously added and dissolved by stirring. A working solution containing 10% (w / w) lauroyl alanine was prepared.

[0078] Method of use: take an appropriate amount of the product in the palm and rub it on wet hair, then rinse with clean water after massaging.

[0079] 2 Test Subjects

[0080] Chinese natural hair bundle *6 (mildly damaged), length 24 cm, width 2 cm, weight 4 g;

[0081] Chinese natural hair bundle *6, length 20 cm, weight 2 g;

[0082] Chinese natural hair tress*2 (lightly damaged), length 24 cm, weight 1 g, hair diameter 70±10 μm;

[0083] Chinese natural hair tress*2 (lightly damaged), length 24 cm, weight 2 g.

[0084] 3. Combing force test

[0085] 1). Test preparation: 6 groups of hair tresses were prepared, divided into blank group and experimental group.

[0086] 2). Combing force determination method: Dia-stron MTT 175 multifunctional hair tester was used to measure the work W done by combing the whole hair tress, and then divided by the measurement length to obtain the combing force F.

[0087] 3). Blank group: the blank group used water to wet the hair tress to simulate the washing process, and the combing force was measured, recorded as F 湿-空白 , and then placed in a (60±1) °C oven, and the combing force was measured after 30 min, recorded as F 干-空白 . Each piece was tested 5 times.

[0088] 4). Experimental group: 1.6 g of product was evenly applied to the hair tress to simulate the washing process, and the hair tress was dried, and the combing force was measured, recorded as F 湿-实验 . Then placed in a (60±1) °C oven, and the combing force was measured after 30 min, recorded as F 干-实验 . Each piece was tested 5 times.

[0089] 4. Fluff test

[0090] 1). Test preparation: 6 groups of hair tresses were prepared, divided into blank group and experimental group.

[0091] 2). Work determination method: Dia-stron MTT 175 multifunctional hair tester was used to measure the work W done by the hair tress passing through the fixed aperture.

[0092] 3). Blank group: the hair tress was wet to simulate the washing process, and placed in a (60±1) °C oven, and the work was measured after 30 min, recorded as W 空白 . Each bundle was tested 3 times.

[0093] 4). Experimental group: the hair tress was wet to simulate the washing process, and 0.8 g of product was evenly applied to the hair tress, and then washed, and placed in a (60±1) °C oven, and the work was measured after 30 min, recorded as W 实验 . Each bundle was tested 3 times.

[0094] 5. Tensile strength test

[0095] 1). Test preparation: 2 groups of hair tresses were prepared, divided into blank group and experimental group.

[0096] 2). Tensile strength test method: Dia-stron MTT 175 hair multifunctional tester was used to measure the stress when the hair strand was broken, and the data was recorded as F (gmf).

[0097] 3). Blank group: The blank group used clean water to wet the hair bundle to simulate the washing process, and was placed in an oven at (60 ± 1) °C. After 30 min, it was taken out and the above operation was repeated 12 times. The tensile strength was measured, and the diameter was repeated (20 hair strands were tested).

[0098] 4). Experimental group: 0.4 g of product was evenly applied to the hair bundle, and after 1 min, the washing process was simulated. It was placed in an oven at (60 ± 1) °C. After 30 min, it was taken out and the above operation was repeated 12 times. The tensile strength was measured, and the diameter was repeated (20 hair strands were tested).

[0099] 6 Hair cuticle test

[0100] 1). Test preparation: 2 groups of hair bundles were prepared and randomly divided into blank and experimental groups.

[0101] 2). Blank group: The blank group used clean water to wet the hair bundle to simulate the washing process, and was placed in an oven at (60 ± 1) °C. After 30 min, it was taken out and the above operation was repeated 12 times.

[0102] 3). Experimental group: 0.8 g of product was evenly applied to the hair bundle, and after 1 min, the washing process was simulated. It was placed in an oven at (60 ± 1) °C. After 30 min, it was taken out and the above operation was repeated 12 times.

[0103] 4). Electron microscope was used to collect hair images.

[0104] 7 Test instruments

[0105] Dia-stron MTT 175 hair multifunctional tester (Dia-Stron Company, UK), PL2002 electronic balance (METTLER TOLEDO Company, Switzerland), oven LRH-250F (Haier Industry, China), Strauss instant electric water faucet (Haier, China), micrometer (Chuanliang, China), comb (Shaxuan 105), circular plastic plate, timer, ribbon (2.5*100 mm), Quanta450 electron microscope (FEI, USA).

[0106] 8 Test results

[0107] 8.1 Dry / wet combing force test results

[0108] The combing force results of the blank group and the experimental group after testing are shown in Table 1. The lower the measured value, the smaller the wet / dry combing force. Compared with the blank group, the dry combing force of the hair tress of the experimental group was significantly reduced by 80.20%, and the wet combing force was significantly reduced by 40.04%, indicating that lauroyl alanine can reduce combing force and has the effect of repairing hair cuticle. The typical photos of hair cuticle changes of the hair tress after testing of the blank group and the experimental group are shown in Figure 1.

[0109] Table 1 Combing force statistics Note: The confidence interval is 95%, the normality test P value is > 0.05, indicating that the data conforms to the normal distribution, otherwise, it does not conform to the normal distribution. Calculate the difference, P value < 0.05, indicating that compared with the blank group, there is a significant difference in the parameter, marked with “*”, the same below.

[0110] 8.2 Fluff test results

[0111] The work results of the blank group and the experimental group after testing are shown in Table 2. The larger the measured value, the more fluffy the hair. Compared with the blank group, the work of the experimental group was significantly increased by 94.34%, indicating that lauroyl alanine has a fluffing effect.

[0112] Table 2 Work statistics

[0113] 8.3 Tensile strength test results

[0114] The tensile strength results of the blank group and the experimental group after testing are shown in Table 3. The larger the measured value, the stronger the tensile strength. Compared with the blank group, the tensile strength of the experimental group was significantly increased by 7.11%, indicating that lauroyl alanine has the effect of preventing hair breakage.

[0115] Table 3 Tensile strength statistics

[0116] In addition, those skilled in the art can understand that although some embodiments described herein include certain features included in other embodiments but not other features, the combination of features of different embodiments means to be within the scope of the present application and form different embodiments. For example, in the claims, any one of the claimed embodiments can be used in any combination.

Claims

1. Use of a composition comprising N-long chain acyl alanine and / or a salt thereof for increasing the breakage resistance of hair.

2. Use of a composition comprising N-long chain acyl alanine and / or a salt thereof for increasing the bulk of hair.

3. Use of a composition comprising N-long chain acyl alanine and / or a salt thereof for repairing hair cuticles.

4. Use according to any one of claims 1 to 3, characterized in that, The composition is a composition for topical application.

5. Use according to any one of claims 1 to 3, characterized in that, The composition is a cosmetic composition, preferably a hair care composition.

6. Use according to any one of claims 1 to 3, characterized in that, The N-long chain acyl alanine and / or a salt thereof is present in the composition in an amount of 1% or more by weight, preferably 2% or more by weight, more preferably 3% or more by weight.

7. Use according to any one of claims 1 to 3, characterized in that, The composition comprises N-long chain acyl alanine and a basic amino acid, or a salt of N-long chain acyl alanine and a basic amino acid.

8. Use according to any one of claims 1 to 3, characterized in that, The composition comprises a sodium salt, a potassium salt or an ammonium salt of N-long chain acyl alanine.

9. Use according to any one of claims 1 to 3, characterized in that, The N-long chain acyl group of the N-long chain acyl alanine is derived from a saturated or unsaturated linear or branched fatty acid having 8 to 22 carbon atoms; preferably, the N-long chain acyl group is selected from one or more of octanoyl, decanoyl, undecanoyl, lauroyl, myristoyl, pentadecanoyl, palmitoyl, stearoyl, oleoyl, linoleoyl, isostearoyl, coconut oil fatty acyl, palm oil fatty acyl.

10. Use according to claim 9, characterized in that, The N-long chain acyl alanine is selected from one or more of N-octanoyl-L-alanine, N-decanoyl-L-alanine, N-undecanoyl-L-alanine, N-lauroyl-L-alanine, N-cocoyl-L-alanine, N-myristoyl-L-alanine, N-pentadecanoyl-L-alanine, N-palmitoyl-L-alanine, N-stearoyl-L-alanine, N-isostearoyl-L-alanine, N-oleoyl-L-alanine, N-linoleoyl-L-alanine, preferably N-lauroyl-L-alanine.

11. Use according to claim 7, characterized in that, The basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, diaminopropionic acid, preferably arginine and / or lysine, most preferably L-arginine.

12. A method of preventing hair breakage comprising: i) a step of applying to the hair a composition comprising N-long chain acyl alanine and / or a salt thereof; ii) a step of leaving the composition on the hair; iii) a step of rinsing and / or washing the hair.

13. A method of increasing hair volume comprising: i) a step of applying to the hair a composition comprising N-long chain acyl alanine and / or a salt thereof; ii) a step of leaving the composition on the hair; iii) a step of rinsing and / or washing the hair.

14. A method of repairing a hair cuticle comprising: i) a step of applying to the hair a composition comprising N-long chain acyl alanine and / or a salt thereof; ii) a step of leaving the composition on the hair; iii) a step of rinsing and / or washing the hair.

15. The method according to any one of claims 12-14, characterized in that, The N-long chain acyl alanine and / or a salt thereof is present in the composition in an amount of 1% or more by weight, preferably 2% or more by weight, more preferably 3% or more by weight.

16. The method according to any one of claims 12-14, characterized in that, The composition comprises N-long chain acyl alanine and a basic amino acid, or comprises a salt of N-long chain acyl alanine and a basic amino acid, or comprises a sodium / potassium / ammonium salt of N-long chain acyl alanine.

17. The method according to any one of claims 12-16, characterized in that, The N-long chain acyl alanine is selected from one or more of N-octanoyl-L-alanine, N-decanoyl-L-alanine, N-undecanoyl-L-alanine, N-lauroyl-L-alanine, N-myristoyl-L-alanine, N-pentadecanoyl-L-alanine, N-palmitoyl-L-alanine, N-stearoyl-L-alanine, N-isostearoyl-L-alanine, N-oleoyl-L-alanine, N-linoleoyl-L-alanine, preferably N-lauroyl-L-alanine; and the basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, diaminopropionic acid, preferably L-arginine.

18. A cleansing composition having the effect of enhancing the volume of hair and / or repairing the cuticle of hair and / or preventing breakage of hair, characterized in that, The composition comprises N-long chain acyl alanine and a basic amino acid; the weight percentage of N-long chain acyl alanine in the composition is 2% or more, preferably 4% or more; the weight percentage of the basic amino acid in the composition is 1% or more, preferably 2% or more; the composition is free or substantially free of sulfate surfactants, ethoxylate surfactants and fatty acid salt surfactants.

19. The cleaning composition of claim 18, wherein, The N-long chain acyl alanine is selected from one or more of N-octanoyl-L-alanine, N-decanoyl-L-alanine, N-undecanoyl-L-alanine, N-lauroyl-L-alanine, N-myristoyl-L-alanine, N-pentadecanoyl-L-alanine, N-palmitoyl-L-alanine, N-stearoyl-L-alanine, N-isostearoyl-L-alanine, N-oleoyl-L-alanine, N-linoleoyl-L-alanine, preferably N-lauroyl-L-alanine; and the basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, diaminopropionic acid, preferably L-arginine.

20. A non-therapeutic cosmetic method comprising topically applying to the hair a cosmetic composition for enhancing the hair's volume and / or repairing the hair cuticle and / or preventing hair breakage, the cosmetic composition comprising N-long chain acyl alanine and / or a salt thereof.

21. The method of claim 20, wherein, The weight percentage of N-long chain acyl alanine and / or a salt thereof in the composition is 1% or more, preferably 2% or more, more preferably 3% or more.

22. The cosmetic method according to any one of claims 20-21, characterized in that, The composition comprises N-long chain acyl alanine and a basic amino acid, or comprises a salt of N-long chain acyl alanine and a basic amino acid, or comprises a sodium / potassium / ammonium salt of N-long chain acyl alanine.

23. The cosmetic method according to any one of claims 20-22, characterized in that, The N-long chain acyl amino acid is selected from one or more of N-octanoyl-L-alanine, N-decanoyl-L-alanine, N-undecanoyl-L-alanine, N-lauroyl-L-alanine, N- myristoyl-L-alanine, N-pentadecanoyl-L-alanine, N-palmitoyl-L-alanine, N-stearoyl-L- alanine, N-isostearoyl-L-alanine, N-oleoyl-L-alanine, N-linoleoyl-L-alanine, preferably N- lauroyl-L-alanine; the basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, diaminopropionic acid, preferably L-arginine. The N-long chain acyl amino acid is selected from one or more of N-octanoyl-L-alanine, N-decanoyl-L-alanine, N-undecanoyl-L-alanine, N-lauroyl-L-alanine, N- myristoyl-L-alanine, N-pentadecanoyl-L-alanine, N-palmitoyl-L-alanine, N-stearoyl-L- alanine, N-isostearoyl-L-alanine, N-oleoyl-L-alanine, N-linoleoyl-L-alanine, preferably N- lauroyl-L-alanine; the basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, diaminopropionic acid, preferably L-arginine. The N-long chain acyl amino acid is selected from one or more of N-octanoyl-L-alanine, N-decanoyl-L-alanine, N-undecanoyl-L-alanine, N-lauroyl-L-alanine, N- myristoyl-L-alanine, N-pentadecanoyl-L-alanine, N-palmitoyl-L-alanine, N-stearoyl-L- alanine, N-isostearoyl-L-alanine, N-oleoyl-L-alanine, N-linoleoyl-L-alanine, preferably N- lauroyl-L-alanine; the basic amino acid is selected from one or more of arginine, lysine, citrulline, ornithine, creatine, histidine, diaminobutyric acid, diaminopropionic acid, preferably L-arginine.

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