Antibacterial bristles, preparation method therefor, and use thereof

Abstract

Disclosed are antibacterial bristles, a preparation method therefor, and a use thereof. The preparation method for the antibacterial bristles comprises: after the bristles are treated with oxygen plasma, adding a chitosan solution and a cyanuric chloride solution, reacting at pH 6-7 and a temperature ≤15°C, then immersing in a quaternary ammonium salt solution, followed by drying to obtain the antibacterial bristles. The antibacterial bristles prepared by this method have excellent antibacterial properties and long-lasting antibacterial effects, wide applicability, and are easy to produce industrially.

Description

Antibacterial bristles, and preparation method and application thereof TECHNICAL FIELD

[0001] The present application relates to the technical field of fiber materials, in particular to an antibacterial bristle, and a preparation method and application thereof. BACKGROUND

[0002] Cosmetic brushes are mainly composed of a brush handle and bristles, and common types include powder brushes, blush brushes, eyebrow brushes, and eye shadow brushes. By using the bristles to adsorb powder, paste, or liquid cosmetics, the amount of cosmetics can be controlled, and the cosmetics can be better integrated with the skin. Since the bristles need to directly contact hair, skin, and other parts while adsorbing cosmetics, sebum and dirt can easily adhere to the bristles, causing the breeding of bacteria and other microorganisms. If the cosmetic brushes themselves contain bacteria, mold, and other microorganisms, skin problems or infections can occur. Some studies have shown that a large number of bacteria and other microorganisms can parasitize on uncleaned cosmetic brushes, which can include pathogenic bacteria, and long-term use of such cosmetic brushes can cause skin problems, allergic reactions, or infectious diseases.

[0003] In order to improve the safety and hygiene of people using cosmetic brushes, researchers have endeavored to develop cosmetic brushes with antibacterial functions, such as effectively reducing the breeding of bacteria by adding antibacterial agents to the cosmetic brush materials, thereby maintaining the hygiene of the cosmetic brushes. Antibacterial agents include two categories of metal-based antibacterial agents and non-metal-based antibacterial agents. Among them, metal-based antibacterial agents are suitable for use in high-hygiene environments because the antibacterial cosmetic brushes prepared by metal-based antibacterial agents have stable and long-lasting antibacterial performance. However, metal-based antibacterial agents can cause skin allergies in some people, and the bristles are relatively hard, which is not suitable for all skin types. Non-metal-based antibacterial agents have less impact on the use of cosmetic brushes, and it is easier to achieve a soft and comfortable texture, which is more suitable for sensitive skin. However, such cosmetic brushes are difficult to achieve long-lasting and efficient antibacterial effects, and the antibacterial performance is unstable, requiring regular replacement or maintenance.

[0004] Therefore, there is a need to develop an antibacterial cosmetic brush with good antibacterial properties and wide applicability. SUMMARY

[0005] The present application aims to at least solve one of the technical problems existing in the prior art. To this end, the present application provides a preparation method of antibacterial bristles, which improves the antibacterial properties and durability of the bristles, and does not require the addition of metal-based antibacterial agents, thereby having wide applicability.

[0006] The present application also provides antibacterial bristles prepared by the above preparation method.

[0007] The present application also provides the application of the above antibacterial bristles.

[0008] Specifically, the first aspect of the present application relates to a preparation method of antibacterial bristles, comprising the following steps:

[0009] S1: dissolving chitosan in an acidic aqueous solution to obtain a chitosan solution; dissolving cyanuric chloride in a solvent to obtain a cyanuric chloride solution;

[0010] S2: adding the bristles after oxygen plasma treatment into the chitosan solution, adding the cyanuric chloride solution, reacting at pH 6-7 and temperature ≤15℃, and separating the bristles after reaction to obtain modified bristles;

[0011] S3: immersing the modified bristles in a quaternary ammonium salt solution for treatment, and drying to obtain the antibacterial bristles.

[0012] The preparation method of the antibacterial bristles according to the first aspect of the embodiments of the present application has at least the following beneficial effects:

[0013] The oxygen plasma treatment on the bristles activates free radicals by using oxygen plasma to introduce oxygen-containing groups such as hydroxyl groups on the fiber surface, improve the surface activity of the fiber, and promote the reaction between cyanuric chloride and the activated hydroxyl groups on the fiber surface. At the same time, cyanuric chloride can react with the hydroxyl groups of chitosan, and then chitosan can be firmly combined on the fiber surface, which improves the defect that the antibacterial agent is weakly combined with the fiber surface. Oxygen plasma treatment can also increase the roughness of the fiber surface, improve the wettability of the fiber surface, and help the adsorption of the antibacterial agent (chitosan and quaternary ammonium salt) on the fiber surface.

[0014] Chitosan and quaternary ammonium salt both have antibacterial activity. The reaction of cyanuric chloride with chitosan and the hydroxyl groups on the fiber surface is beneficial to the adsorption of chitosan on the fiber surface, which can further promote the adsorption of quaternary ammonium salt on the fiber surface (for example, more hydrogen bond interactions are formed, and chitosan itself has certain adhesion), and significantly improve the antibacterial property.

[0015] This method does not need to add metal-based antibacterial agents, can better meet the use needs of different groups of people, and has simple process, wide raw material sources, and easy industrial production.

[0016] In some embodiments, in step S1, the acidic aqueous solution is an acetic acid solution with a mass percentage concentration of 1%-8%. Non-limiting examples of the concentration of the acetic acid solution include any value in 1%, 2%, 3%, 4%, 5%, 6%, 7%, 8% or any value between any two of them.

[0017] In some embodiments, in step S1, the temperature for dissolving chitosan in the acidic aqueous solution is 25-80℃. Non-limiting examples include any value in 25℃, 30℃, 40℃, 50℃, 60℃, 70℃, 80℃ or any value between any two of them.

[0018] Appropriately increasing the concentration of the acetic acid solution or heating during the dissolving process is beneficial to the rapid dissolution of chitosan.

[0019] In some embodiments, in step S1, the mass percentage concentration of chitosan in the chitosan solution is 1-5%, non-limiting examples are any value selected from the group consisting of 1%, 2%, 3%, 4%, 5%, or any value between any two of them.

[0020] In some embodiments, in step S1, the solvent is selected from the group consisting of one or more of N,N-dimethylformamide, tetrahydrofuran and acetonitrile.

[0021] In some embodiments, in step S1, the mass percentage concentration of cyanuric chloride solution is 5-10%, non-limiting examples are any value selected from the group consisting of 5%, 6%, 7%, 8%, 9%, 10%, or any value between any two of them.

[0022] In some embodiments, in step S2, the conditions of the oxygen plasma treatment are: 2000-3000 Pa oxygen atmosphere, voltage of 150-250 V, and treatment time of 5-15 min. Under these conditions, the treatment effect is better, and the resulting fiber has better antibacterial properties. Non-limiting examples of oxygen pressure are: 2000 Pa, 2200 Pa, 2500 Pa, 2800 Pa, 3000 Pa, or any value between any two of them. Non-limiting examples of voltage are: 150 V, 180 V, 200 V, 220 V, 250 V, or any value between any two of them. Non-limiting examples of oxygen plasma treatment time are: 5 min, 10 min, 15 min, or any value between any two of them.

[0023] In some embodiments, in step S2, the solid-liquid ratio of the bristles to the chitosan solution is 5-20 g / 100 mL, non-limiting examples are any value selected from the group consisting of 5 g / 100 mL, 10 g / 100 mL, 15 g / 100 mL, 20 g / 100 mL, or any value between any two of them.

[0024] In some embodiments, in step S2, the solid-liquid ratio of the bristles to the chitosan solution is 5-10 g / 100 mL.

[0025] In some embodiments, in step S2, the mass ratio of cyanuric chloride to chitosan is 1-2:1, non-limiting examples are any value selected from the group consisting of 1.1:1, 1.2:1, 1.3:1, 1.4:1, 1.5:1, 1.6:1, 1.7:1, 1.8:1, 2:1, or any value between any two of them.

[0026] In some embodiments, in step S2, the mass ratio of cyanuric chloride to chitosan is 1.4-1.8:1.

[0027] In some embodiments, in step S2, the pH of the reaction is any one of 6, 6.5, 7, or any value between any two of them.

[0028] In some embodiments, in step S2, the pH is adjusted to 6-7 using an acid-binding agent.

[0029] In some embodiments, in step S2, the acid-binding agent is selected from the group consisting of one or more of sodium hydroxide, potassium hydroxide, sodium carbonate, sodium bicarbonate, and organic amine.

[0030] In some embodiments, in step S2, the acid-binding agent is selected from the group consisting of one or more of N,N-diisopropylethylamine, pyridine, trimethylamine, triethylamine, and isopropylamine.

[0031] In some embodiments, in step S2, the temperature of the reaction is any one of 0-10°C, non-limiting examples of which are 0°C, 5°C, 10°C, or any value between any two of them. A lower reaction temperature is conducive to the reaction of cyanuric chloride with the active hydroxyl group, reducing side reactions.

[0032] In some embodiments, in step S2, the reaction time is any one of 2-4h, non-limiting examples of which are 2h, 3h, 4h, or any value between any two of them.

[0033] In some embodiments, in step S2, stirring is performed during the reaction. Stirring plays a role in promoting dispersion, and the present application does not limit the specific stirring rate.

[0034] In some embodiments, in step S2, the method of separating the bristles is filtration.

[0035] In some embodiments, in step S2, the filtered bristles are further subjected to water washing.

[0036] In some embodiments, in step S3, the quaternary ammonium salt in the quaternary ammonium salt solution comprises dimethyl octadecyl [3-(trimethoxysilyl) propyl] ammonium chloride (CAS No. 27668-52-6) and polydimethyl diallyl ammonium chloride (CAS No. 26062-79-3).

[0037] Quaternary ammonium salts can interact with the negatively charged cell walls of microorganisms through electrostatic adsorption, thereby destroying the cell structure of the microorganisms. Dimethyl octadecyl [3-(trimethoxysilyl) propyl] ammonium chloride contains siloxy groups that can bind to the hydroxyl groups on the surface of the bristles (including residual hydroxyl groups of chitosan and hydroxyl groups on the surface of the bristles) after hydrolysis, achieving firm binding. Polydimethyl diallyl ammonium chloride molecules contain multiple quaternary ammonium salt groups, i.e., multiple electrostatic adsorption sites, which can enhance the antibacterial effect. The combination of the two can improve the antibacterial properties and provide extensive and long-lasting antibacterial protection.

[0038] In some embodiments, in step S3, the mass ratio of dimethyl octadecyl [3- (trimethoxysilyl) propyl] ammonium chloride and polydimethyl diallyl ammonium chloride in the quaternary ammonium salt solution is 2-4: 1, and non-limiting examples include any one of 2: 1, 2.5: 1, 3: 1, 3.5: 1, 4: 1 or any value between any two of them.

[0039] In some embodiments, in step S3, the mass ratio of dimethyl octadecyl [3- (trimethoxysilyl) propyl] ammonium chloride and polydimethyl diallyl ammonium chloride in the quaternary ammonium salt solution is 3-4: 1.

[0040] In some embodiments, in step S3, the total mass percentage concentration of quaternary ammonium salt in the quaternary ammonium salt solution is 2%-10%, and non-limiting examples include any one of 2%, 3%, 4%, 5%, 6%, 7%, 8%, 9%, 10% or any value between any two of them.

[0041] In some embodiments, in step S3, the solvent in the quaternary ammonium salt solution is selected from a combination of one or more of water and alcohol. Non-limiting examples of alcohol include a combination of one or more of methanol, ethanol and isobutanol.

[0042] In some embodiments, in step S3, the time of the immersion treatment is 1-3 min, and non-limiting examples include any one of 1 min, 1.5 min, 2 min, 2.5 min, 3 min or any value between any two of them.

[0043] In some embodiments, in step S3, the solid-liquid ratio of the modified bristles to the quaternary ammonium salt solution is not particularly limited, and generally the amount of quaternary ammonium salt is controlled to be greater than the saturated adsorption amount within the immersion time, and at the same time the quaternary ammonium salt solution can be repeatedly used for multiple times of immersion treatment. After leaching, the fibers are drained and dried, and the drained liquid is reused for the immersion treatment.

[0044] In some embodiments, in step S3, the temperature of the drying is 70-90°C, and non-limiting examples include any one of 70°C, 80°C, 90°C or any value between any two of them.

[0045] In some embodiments, the material of the bristles is a combination of one or more of synthetic fibers and animal-derived fibers.

[0046] The material of the synthetic fibers can be any type known in the art, and non-limiting examples include a combination of one or more of polyethylene terephthalate, polybutylene terephthalate, polytrimethylene terephthalate and nylon.

[0047] The bristles can also use various animal-derived fibers (animal hair) known in the art, non-limiting examples of which are: wool, squirrel hair, horsehair, rabbit hair, fox hair, mink hair, chinchilla hair, weasel hair, etc.

[0048] The second aspect of the present application relates to the antibacterial bristles prepared by the above-mentioned preparation method.

[0049] The antibacterial bristles are prepared by the above-mentioned preparation method, and thus have at least all the beneficial effects of the embodiments of the above-mentioned preparation method. Furthermore, the prepared antibacterial bristles have excellent antibacterial properties and long-lasting antibacterial effects, and are suitable for use by a variety of people.

[0050] The third aspect of the present application relates to a cosmetic brush comprising the above-mentioned antibacterial bristles.

[0051] The cosmetic brush comprises the above-mentioned antibacterial bristles, thereby improving the antibacterial properties and their durability of the cosmetic brush, and better ensuring the long-term use hygiene and wide applicability of the cosmetic brush.

[0052] In some embodiments, the cosmetic brush comprises at least one of a foundation brush, a concealer brush, a powder brush, a blush brush, a highlighter brush, an eyeshadow brush, an eyeliner brush, an eyebrow brush, a lip brush, a contour brush, or a mascara brush.

[0053] In this document, "plurality" includes two or more; in reference to a numerical quantity, means that quantity includes each and every whole number between the two ends of the range and any sub-ranges therebetween.

[0054] Other features and advantages of the present application will be set forth in the description that follows, and in part will become apparent to those skilled in the art upon examination of the following or can be learned by practice of the application. DETAILED DESCRIPTION

[0055] Embodiments of the present application are described in detail below, the embodiments described below are exemplary and are only used to explain the present application, and cannot be understood as a limitation of the present application.

[0056] In the following examples, some of the raw materials are described as follows:

[0057] Dimethyloctadecyl [3-(trimethoxysilyl)propyl] ammonium chloride: Bi-ome AM5, Devan Company.

[0058] Polydimethyl diallyl ammonium chloride: Devatec NA, Devan Company.

[0059] The raw materials involved are commercially available conventional products unless otherwise specified.

[0060] Bacteriostatic rate test: reference GB / T 20944.2-2007 test, sample unwashed, mass 0.4g, TSB medium, test bacteria suspension concentration 10 7 CFU / mL, test volume 0.2mL (incubated for 24h after mixing with sample).

[0061] Antibacterial durability test: the bristles were cut into fiber bundles with diameter 2cm and length 4cm, the fiber bundles were inserted into the loose powder to saturate the degree of powder sticking, the fiber bundles with stuck powder were rubbed by hand for 200 times (to simulate extreme use conditions), then the loose powder was washed away, dried, and the bacteriostatic rate was tested according to the method described above.

[0062] Example 1

[0063] An antibacterial bristle was prepared, the preparation method comprising the steps of:

[0064] 1. Chitosan was added into an aqueous acetic acid solution (5wt%) and dissolved by heating to 50°C to prepare a chitosan solution with mass concentration of 2wt%.

[0065] 2. Cyanuric chloride was dissolved in DMF to obtain a cyanuric chloride solution with mass concentration of 8wt%.

[0066] 3. Nylon bristles were subjected to oxygen plasma treatment, the treatment parameters being: oxygen atmosphere of 2500Pa, voltage of 200V, and treatment time of 10min.

[0067] 4. The bristles after oxygen plasma treatment were immersed in the chitosan solution, the solid-liquid ratio being 8g / 100mL, the temperature being controlled at 5°C, the cyanuric chloride solution being slowly added so that the mass ratio of cyanuric chloride to chitosan was 1.5:1, sodium hydroxide was added to adjust the pH to 6.5, and slow stirring (100rpm) was performed for 3h, then the bristles were filtered, washed with deionized water, and drained.

[0068] 5. Quaternary ammonium salt antibacterial agent Bi-ome AM5 (containing solvent methanol aqueous solution, mainly water) and Devatec NA (containing solvent water) were mixed so that the mass ratio of dimethyl octadecyl [3- (trimethoxysilyl) propyl] ammonium chloride and polydimethyl diallyl ammonium chloride was 3:1, deionized water was added to adjust the total concentration to 5wt%, and a quaternary ammonium salt solution was obtained.

[0069] 6. The bristles after step 4 were immersed in the quaternary ammonium salt solution of step 5 for 1min, taken out and drained, and the drained liquid was reused for immersion treatment, and the obtained bristles were dried at 70°C to obtain the antibacterial bristles.

[0070] Example 2

[0071] An antibacterial bristle was prepared, the preparation method comprising the steps of:

[0072] 1. Dissolve chitosan in acetic acid aqueous solution (5 wt%) by heating to 50°C to form a chitosan solution with a mass concentration of 3 wt%.

[0073] 2. Dissolve cyanuric chloride in DMF to form a cyanuric chloride solution with a mass concentration of 6 wt%.

[0074] 3. Subject nylon bristles to oxygen plasma treatment with the following parameters: 2500 Pa oxygen atmosphere, voltage 200 V, and treatment time 10 min.

[0075] 4. Immerse the bristles treated by oxygen plasma in the chitosan solution described above at a solid-liquid ratio of 10 g / 100 mL and a controlled temperature of 5°C. Slowly add the cyanuric chloride solution such that the mass ratio of cyanuric chloride to chitosan is 1.6:1. Add sodium hydroxide to adjust the pH to 6.5. Slowly stir (100 rpm) for 3 h, filter, and take the bristles. Wash the bristles with deionized water and then drain.

[0076] 5. Mix the quaternary ammonium salt antibacterial agents Bi-ome AM5 (containing a solvent, methanol aqueous solution, mainly water) and Devatec NA (containing a solvent, water) such that the mass ratio of dimethyl octadecyl [3-(trimethoxysilyl) propyl] ammonium chloride and polydimethyl diallyl ammonium chloride is 3.5:1. Add deionized water to adjust the total concentration to 5 wt% to obtain a quaternary ammonium salt solution.

[0077] 6. Immerse the bristles treated in step 4 in the quaternary ammonium salt solution of step 5 for 2 min, take them out, and drain. The drained liquid is reused for immersion treatment. The obtained bristles are dried at 70°C to obtain the antibacterial bristles.

[0078] Comparative Example 1 (without oxygen plasma treatment)

[0079] An antibacterial bristle was prepared by the following method:

[0080] 1. Dissolve chitosan in acetic acid aqueous solution (5 wt%) by heating to 50°C to form a chitosan solution with a mass concentration of 2 wt%.

[0081] 2. Dissolve cyanuric chloride in DMF to form a cyanuric chloride solution with a mass concentration of 8 wt%.

[0082] 3. Immerse the bristles in the chitosan solution described above at a solid-liquid ratio of 8 g / 100 mL and a controlled temperature of 5°C. Slowly add the cyanuric chloride solution such that the mass ratio of cyanuric chloride to chitosan is 1.5:1. Add sodium hydroxide to adjust the pH to 6.5. Slowly stir (100 rpm) for 3 h, filter, and take the bristles. Wash the bristles with deionized water and then drain.

[0083] 4. Mix the quaternary ammonium salt antibacterial agent Bi-ome AM5 (containing a solvent methanol aqueous solution, mainly water) and Devatec NA (containing a solvent water) to make the mass ratio of dimethyl octadecyl [3- (trimethoxysilyl) propyl] ammonium chloride and polydimethyl diallyl ammonium chloride in them 3:1, add deionized water to adjust the total concentration to 5wt%, and obtain a quaternary ammonium salt solution.

[0084] 5. Dip the brush hair treated in step 3 into the quaternary ammonium salt solution in step 4, stay for 1 min, take out and drain, and the drained liquid is recycled for the dipping treatment, and the obtained brush hair is dried at 70℃, and the brush hair is obtained.

[0085] Comparative Example 2 (without adding cyanuric chloride modification)

[0086] An antibacterial brush hair is prepared, and the preparation method comprises the following steps:

[0087] 1. Add chitosan into an acetic acid aqueous solution (5wt%), heat to 50℃ to dissolve, and prepare a chitosan solution with a mass concentration of 2wt%.

[0088] 2. Take nylon brush hair, and perform oxygen plasma treatment, and the treatment parameters are: 2500Pa oxygen atmosphere, voltage 200V, and treatment time 10min.

[0089] 3. Dip the brush hair treated by the oxygen plasma treatment into the chitosan solution, and the solid-liquid ratio is 8g / 100mL, add sodium hydroxide to adjust the pH to 8, slowly stir (100rpm) for 3h, centrifuge, take the precipitate, wash with deionized water, and then drain.

[0090] 4. Mix the quaternary ammonium salt antibacterial agent Bi-ome AM5 (containing a solvent methanol aqueous solution, mainly water) and Devatec NA (containing a solvent water) to make the mass ratio of dimethyl octadecyl [3- (trimethoxysilyl) propyl] ammonium chloride and polydimethyl diallyl ammonium chloride in them 3:1, add deionized water to adjust the total concentration to 5wt%, and obtain a quaternary ammonium salt solution.

[0091] 5. Dip the brush hair treated in step 3 into the quaternary ammonium salt solution in step 4, stay for 1 min, take out and drain, and the drained liquid is recycled for the dipping treatment, and the obtained brush hair is dried at 70℃, and the brush hair is obtained.

[0092] The bacteriostatic rates of the brush hairs in Example 1, Example 2 and Comparative Examples 1 and 2 are shown in Table 1.

[0093] Table 1

[0094] It can be known from the above effects that the brush hair prepared in the examples has a higher bacteriostatic rate, good bacteriostatic durability, and better antibacterial performance.

[0095] From the comparison of Comparative Example 1 and Example 1, it can be seen that the antibacterial rate and its persistence are significantly reduced without oxygen plasma treatment, which may be due to the decrease of active hydroxyl groups on the fiber surface, and the lack of surface roughening effect of oxygen plasma, affecting the adhesion of chitosan and quaternary ammonium salt on the fiber surface.

[0096] From the performance comparison of Comparative Example 2 and Example 1, it can be seen that the antibacterial persistence is dramatically reduced without the addition of cyanuric chloride modification, which may be due to the lack of cross-linking and bridging effect of cyanuric chloride, affecting the interfacial adhesion. However, the antibacterial rate of Comparative Example 2 is higher than that of Comparative Example 1, indicating that oxygen plasma treatment may be beneficial to the adhesion of chitosan and quaternary ammonium salt (higher fiber surface energy and increased surface area after roughening).

[0097] In summary, the antibacterial bristles prepared in this example have excellent antibacterial properties and persistent antibacterial effect, which can better meet the requirements of persistent antibacterial of cosmetic brushes, ensure long-term use hygiene, and do not need to add metal antibacterial agents, making it more widely applicable to a wider population.

[0098] The above has made a detailed description of the embodiments of the present application, but the present application is not limited to the above embodiments, and various changes can be made within the scope of knowledge possessed by those skilled in the art without departing from the purpose of the present application.

Claims

1. A method of making an antibacterial bristle characterized by: The method comprises the following steps: S1: dissolving chitosan in an acidic aqueous solution to obtain a chitosan solution; dissolving cyanuric chloride in a solvent to obtain a cyanuric chloride solution; S2: adding the bristles treated by oxygen plasma into the chitosan solution, adding the cyanuric chloride solution, and reacting at pH 6-7 and a temperature of ≤15℃, and then separating the bristles to obtain modified bristles; S3: immersing the modified bristles in a quaternary ammonium salt solution for impregnation treatment, and drying to obtain the antibacterial bristles.

2. The method of claim 1, wherein: In step S1, the acidic aqueous solution is an acetic acid solution with a mass percentage concentration of 1%-8%; and / or, the temperature for dissolving chitosan in the acidic aqueous solution is 25-80℃; and / or, in the chitosan solution, the mass percentage concentration of chitosan is 1%-5%; and / or, the solvent is selected from a combination of one or more of N,N-dimethylformamide, tetrahydrofuran, and acetonitrile; and / or, the mass percentage concentration of the cyanuric chloride solution is 5%-10%.

3. The method of claim 1, wherein: In step S2, the conditions for the oxygen plasma treatment are as follows: an oxygen atmosphere of 2000-3000 Pa, a voltage of 150-250 V, and a treatment time of 5-15 min.

4. The method of claim 1, wherein: In step S2, the solid-liquid ratio of the bristles to the chitosan solution is 5-20 g / 100 mL; and / or, the mass ratio of cyanuric chloride to chitosan is 1-2:1; and / or, the reaction temperature is 0-10℃; and / or, the reaction time is 2-4 h.

5. The method of claim 1, wherein: In step S2, an acid-binding agent is used to adjust the pH to 6-7; optionally, the acid-binding agent is selected from a combination of one or more of sodium hydroxide, potassium hydroxide, sodium carbonate, sodium bicarbonate, and organic amine.

6. The method of claim 1, wherein: In the quaternary ammonium salt solution, the quaternary ammonium salt includes dimethyl octadecyl [3-(trimethoxysilyl) propyl] ammonium chloride and polydimethyl diallyl ammonium chloride; optionally, the mass ratio of dimethyl octadecyl [3-(trimethoxysilyl) propyl] ammonium chloride to polydimethyl diallyl ammonium chloride is 2-4:

1.

7. The production method according to claim 1 or 6, characterized by: In the quaternary ammonium salt solution, the total mass percentage concentration of the quaternary ammonium salt is 2%-10%; and / or, in the quaternary ammonium salt solution, the solvent is selected from a combination of one or more of water and alcohol.

8. The method of claim 1, wherein: The impregnation treatment time is 1-3 min; and / or, the drying temperature is 70-90℃.

9. An antibacterial bristle characterized by: The antibacterial bristles are prepared by the method according to any one of claims 1-8.

10. A cosmetic brush characterized by: The antibacterial bristles according to claim 9.

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