Engineered transcription repressors and uses thereof

WO2026038105A1PCT designated stage Publication Date: 2026-02-19FOND AZIONE TELETHON +1
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Patent Information

Application Number
PCT/IB2025/058022
Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Priority Date
2024-08-13
Filing Date
2025-08-06
Publication Date
2026-02-19

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Abstract

The present invention aims to treat polyglutamine diseases by silencing the expression of pathogenic alleles using engineered transcription repressors (ETRs). The provided ETRs deposit one or more epigenetic marks that can silence a pathogenic allele.
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Description

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ZFP_HTT_PROM_1 LLESGIHHIGRVTPHATAGMEAKEPRFPAFCDCIRCIGCRMKRFNAFSNRASTDRHT CCSGCAGGGCTGTCCGGGT KHTKIHTGSKPFCRICMRNFS E IDNO: 35 HIRTHTGEKPFACDICGRKFAARDRSNLSR KIHTGSKPFCRICMRNFSDRSWAYLDKHT THTGEKPFACDICGRKFASSDLTLRSRHIR ROM_2 LLR LESGKID HHA IGA RVR TPHATAS GME HTKIH ZFP_HTT_P EAKEPRI FPD AFN CDCO IR: CIGC4 RMKRFNAFHSNRSSHDRTT AGSGEGCTIGDTCNCOG:GG3TGAGT KHTKIHTGSKPFCRICMRNFSRSDNLSA 6 HKIRTHTGEKPFACDICGRKFANRDRKNHT TIHHTTGSKPFCRICMRNFSSGHLARHIR LRGKEDKPFACDICGRKFARKWTLGHTKIH ZFP_HTT_PROM_3 LREKGTIHHA IGA RVR TPHATAS GME EAKEPRI FPD AFN CCOR:IC5MRNFSTSSN GGCTGTCCGGGTGAGTAT RHTKIHT DICGRKFARSDDLSSE IDNO: 37 HIRTHTGGESKPFCRICMRNFSLRHHLTR KIHTGSKKPPFACDICGRKFARRDTLLDHT THTGEKPFAFCRICMRNFSWRSCRSAHIR LRKDAARCDSIECGRKFADSSHRTRHTKIH ZFP_HTT_PROM_4 LLESGAIHHIGRVTPHATAGMEAKEPRI FPD AFN CDCO IR: CIGC6 RMRNFSRSDT CTCGGCTCAGAGTCCACG THTKIHTGSKPF KFADKRTRTSE IDNO: 38 HIRTHTGEKPFACCRICMRNFSRSDNLAR KIHTGSKPFCRDIICCMGRKFAWNYRGSHT THTGEKPFACDICGRRNFSDRSHLTRHIR LRKDAARSE IKDFANDOR:SY7RNTHTKIH ZFP_HTT_PROM_5 LLESGEIHHIGRVTPHATAGMEAKEPRFPAFCDCIRCIGCKMKRFNAFSRSDA CCGGCTGTCGCCCCGCTC KHTKIHTGSKPFCRICMRNFSDTRSSSDSLRSKRSE IDNO:39 HKIIRHTTHGTSGEKKPPFFACCRDIICCGRKFARRDTLRSHT THTGEKPFACDICGRMKRFNAFSSRASHDRHILTSHTTHKIR HTT_PROM_6 LLREGKIDHAGAVRPAAS IH ZFP_ MEA IDNO:8 LTRHIRTH ERPFCRICMRNFSLRHH CTCCAGGCGTCGGCGGGG KHTKIHTGTSGEKKPPFFACCDICGRKFASADRKSE IDNO:40 HIRTHTGEKPFACDIRCIGCRMKRFNAFDSRYSDHYLGARYT KIHTGSKPFCRICMRNFS RHT THTGEKPFACDI DRSNLSRHIR _7 LLR LERGK NID HHA CGRKFARDSRSHTKIH ZFP_HTT_PROM IGA RVR TPHATAS GME EAKEPRI FPD AFN CDCO IR: CIGC9 RMKRFNAFTSSHGNNHLDT GCSGETCGIGDCGNGOGGGATCCT RHTKIHTGSKPFCRICMR : 41 HIRTHTGEKPFA NFSRSDHLSR KIHTGSKPFCCRDIICCMGRRNKFFSARRSSDDDDLLSTKRHT THTGEKPFACDICGRKFA HIR LRKDAARSE IRSADLSRHTKIH ZFP_HTT_PROM_8 LRETGEIHHIGRVTPHATAGMEAKEPRFPD AFN CDCO IR:IC1M0RNFSTNYG GCTGCCGGGACGGGTCCA RHTKIHTGSKPFCRICCMGRRNKFFSARTSGHLSSE IDNO:42 HIRTHTGEKPFACDI SDVLST KIHTGSK CGRKFAVRSRLRRHT THTGEKPFPAFCDCIRCIGCRMKRFNAFSSESRDGTLARHIR LRKDAARSE IDNOLRRYTKIH ZFP_HTT_PROM_9 LEGIH : 11 L GVPAAMAERPFCRICMRNFSRSAH GGGGACTGCCGTGCCGGG RSHRTHKIIRTHTGEKPFACDICGRKFADRSDLSSE IDNO:43 HIRTHHTTGGESKPKFPAFCDCIRCIGCRMKRFNFSHRWHLT KIHTGSKPFCR AASSNRIKHT THTGE ICMRNFSDRSNLSRHIR P_HTT_PROM_10 LLR LETGK VIDK HHAP IGAF RVRACDICGRKFARSDHLSRHTKIH ZF TPHATAS GME EAKEPRI FPD AFN CDCO IR: CIGC1 RM2 KRFNAFDSRGVKG CAGCCGGCCGTGGACTCT RHTKIHTG SNLTSE ID NO:44 HI SKPFCRICMRNFSRSHSLLR KIRHTTHGTSGEKKPPFFACCRDIICCMGRRKFAHRKSLSRHT THTGEKPFACDICGRKFNAFKSLRCSNDRTKLCSHETHKIIRH LRKDAARSE IDNO: 13 ZFP_HTT_PROM_11 LLERGRIHHIGVPAAMAERPFCRICMRNFSDTGD GGATCCCCCGCCGACGCC RHTKIRHTTHTGEKPFACDICGRKFADRSNLTSE IDNO:45 HIRTHTGGESKPKFPAFCDCIRCIGCRMKRFNAFSRSDDLTR KIHTGSKPFCRI HRRSRDHT THTGE CMRNFSDSGGLSKHIR P_HTT_PROM_12 LLRKDKAPAFRACDICGRKFASGHLSRHTKIH ZF SE IDNO: 14 LESGRIHHIGRVTPHATAGMEAKEPRFPAFCDCIRCIGCRMKRFNAFSRSAH GACGGGGCCATGGACGGG RHTKIHTGSKPFCRICMRNFSRDSRDSANLLTSE IDNO:46 HIRTHTGEKPFACDICGRK ST KIHTGSKPFC FADRSTRTKHT THTGEKPFACDIRCIGCRMKRFNAFDSRRSSNALHLSRHIR LRKDAARSE IDNO:TRHTKIH ZFP_HTT_PROM_13 LEGI 15 LSEHHIGRVTPHATAGMEAKEPRFPAFCDCIRCICMRNFSRSDN GGGGCGGAGCGGGATAGG R GRKFATSANLSSE ID NO:47 HHITRKTIHHTTGGESKPKFPAFCDCIRICMRNFSRSDHLSA KIHTGSKPFCRICCMGRRNKFFSARRSSDADNLLTTRRHHIT THTGEKPFACDICGRKFAM R LRKDAARSE IDSYLGRHTKIH ZFP_HTT_PROM_14 LLESGTIHHIGRVTPHATAGMEAKEPRFPAFN CCOR:IC1M6RNFSRSDN GACGGGGACATTAGGCAG HTKIHTGSKPFCRDIICCMGRRNKFFARSTHRTSE IDNO:48 HIRTHTGEKPFAC SWKCLPI KIHT DICGRKFADRSNLTRHT THTGGESKPKFPAFCDCIRCIGCRMKRFNAFSRSAHLSRHIR 5 LLR LESGK RID HHA IGA RVR TPHATAS GME DRSNLTRHTKIH ZFP_HTT_PROM_1 EAKEPRI FPD AFN CDCO IR: CIGC1 RM7 KRFNAFSSRSSDDLHR GGSGECGGIGDGCNGOATGCTGGG RHTKIHTGSKPFCRICMR : 49 HIRTHTGEKPF NFSTSGNLTR KIHTGSKPFACCRDIICCMGRRNKFFSARDSRDSHHLLARHT THTGEKPFACDICGRK SEHIR LRKDAAR FARSAHLSRHTKIH ZFP_HTT_PROM_16 LEGIHGVPAASMEAERIPDFNCO:18 LARHIRTHTGEK RICMRNFSRSDN AGGTAGGGGCGTGGCGAG RHTKIHTGSKPPFFACCRDIICGRKFADRSHLASE IDNO:50 HIRTHTGEKPFACDICGCRMKRFNAFRSSHAKNLHTRRDHAT KTIHHTTGGESKPKFPAFCDCIRCIGCMRNFSRSDNLSAHIR OM_17 LLRKDA RKFARSDHRITHTKIH ZFP_HTT_PR ARSE IDNO: 19 LEAGRIHHIGRVTPHATAGMEAKEPRFPAFCDCIRCIGCRMKRFNAFRSSRDSHDLNT GASCETGCIATGGTAAGGGAG HTKIHTGSKPFCRIC D NO:51 HIRTHTGEKP MRNFSSGSLTR KIHTGSKPFFACCRDIICCMGRRNKFFSASRSSGDHALLPTHT THTGEKPFACDICGRKF PHIR LRKDAARS ADRSNLTRHTKIH ZFP_HTT_PROM_18 LEGIHGVPAAMEAERIPDFNCOR:IC20 LARHIRTHTGEKPFA MRNFSRSDN GCGGCGAGGCGGGACGAG RHTKIHTGSKPFCCRDIICCMGRRKFADRSNLTSE IDNO:52 HIRTHTGEKPF NFSRSDHLSE KIH ACDICGRKFASNHRKTHT THTTGGESKPKFPAFCDCIRCIGCRMKRFNAFSRSADLTRHIR 9 LLR LEAGK RID HHA IGA RVR TPHATAS GME RSDDLTRHTKIH ZFP_HTT_PROM_1 EAKEPRI FPD AFN CDCO IR: CIGC2 RM1 KRFNAFWSLSSSGLNG GGSCEGAAIGDCTNGOT:GT5GTGAA IHTKIHTGSKPFCRICMRNF 3 HIRTHTGEKPFACD SRPYTLRL KIHTGSKPFCRIICCMGRRNKFFSARRRSSNDLLVKRRHHIT THTGEKPFACDICGRKFADR R LRKDAARSE ID SHLARHTKIH ZFP_HTT_PROM_20 LLESGRIHHIGRVTPHATAGMEAKEPRFPAFN CDCO IR:IC2M2RNFSRSAH CCGGGCGAAGGCGCGGGG RHTKIHTGSKPFCRICCMGRRNKFFSARSDDLTSE IDNO:54 HIRTHTGEKPFACD DRSHLTR KIHTGSK ICGRKFASGNLARHT THTGEKPFPAFCDCIRCIGCRMKRFNAFRSRDDRSHLTRHIR LRKDAARSE IDNTLLDHTKIH ZFP_HTT_PROM_21 LEG O: 23 LYHIHHIGRVTPHATAGMEAKEPRFPAFCDCIRCIGCMRNFSLCC AGCAAGGCCGCTGACAGC RH RKFADRSNLTSE ID NO:55 HITRKTIHHTTGGESKPKFPAFCDCIRCIGCMRNFSSSDLSR KIHTGSKP RKFAHRKSLSRHT TH FCRICMRNFSRSDTLSAHIR LRTGKEDKAPAFRACDSIECGRIKDFANAO:CC2LFHHTKIH ZFP_HTT_PROM_22 LLESGTIHHIGRVTPHATAGMEAKEPRFPAFCDCIRCIGCRM4 KRNFSRSDH CACCGGGGCAATGAATGG RHTKIHTGSKPFCRICMRNFFSATNSSNDLLTRVSE IDNO:56 HKIIRHTTHGTSGEKKPPFSACCRDIICGRKFATSGHLSRHT THTGEKPFACDICGCRMKRFNAFDSRRSSNDRHKLTSHETHIR P_HTT_PROM_23 LLREGKIDHAGAVR KIH ZF PSE IDNO: 25 LARHIAAMAERPFCRICMRNFSSGH GGCACGGCAGTCCCCGGA THTKIRHTTHGTGEKPFACDICGRKFADKRDRRSE IDNO:57 YIRTHTGESKPKFPAFCDCIRCIGCRMKRFNAFSSDGRSALSR KIHTGSKPFCDCIRCIGCRMKR DLTRHT THTGEKPFA FNAFDSRRSSHDLSALRSHVTHKIIRH ZFP_HTT_PROM_65 LLRKDAARSE IDNO:26 LESGRIHHIGRVTPHATAGMEAKEPRFPAFCDCIRCIGCRMKRFNAFRSNRDSDD ACGCTGCGCCGGCGGAGGCG KHTKIHTGS NRTSE ID NO:58 HI KPFCRICMRNFSRSDDLTR KIRHTTHGTSGEKKPPFFACCRDIICCMGRRKFARSDDRKTHT THTGEKPFACDICGRKFNAFSSRSSDALDRLRTHRTHKIIRH ZFP_HTT_PROM_62 LLREGKIDHAGAVRPAASMEA IDNO:27 LSEHIRTH ERPFCRICMRNFSRSDH GCTGCTGCTGCTGGAAGG THTKIHTGTSGEKKPPFFACCDICGRKFANAHRKSE IDNO:59 HIRTHTGEKPFACDIRCIGCRMKRFNAFHSRSSTSRDNLRSR KIHTGSKPFCRICMRNFSS HT THTGEKPFACDICG SDLSRHIR OM_69 LLR LEAGK RID HHA RKFAHRSTRNRHTKIH ZFP_HTT_PR IGA RVR TPHATAS GME EAKEPRI FPD AFN CDCO IR: CIGC2 RM8 KRFNAFWSRRGSDDRNV CCSGEGCCIGTGGACTCTGAG KHTKIHTGSKPFCRI D NO:60 HIRTHTGEK CMRNFSDRSNLSR KIHTGSKPPFFACCRDIICCMGRRNKFFSAETRSGGTSLTRHT THTGEKPFACDICGR LARHIR LRKDAAR KFARSDDRKTHTKIH ZFP_HTT_PROM_67 LEGIHGVPAASMEAERIPDFNCOR:29 LSRHIRTHTGEKPF ICMRNFSRSDA GGCGATGCGGGGGGCGTG RHTKIHTGSKPFACCRDIICCMGRKFADRSHLASE IDNO:61 HIRTHTGEKP RNFSRSDHLSR KIH FACDICGRKFASSDLTRHT THTTGGESKPKFPAFCDCIRCIGCRMKRFNFSTSGNLTRHIR 3 LLRKDAARS ADRSHLARHTKIH ZFP_HTT_PROM_6 E IDNO: 30 LEGRIHHIGRVTPHATAGMEAKEPRFPAFCDCIRCIGCRMKRFNAFTSSGSNGLHT GGSGEACGIGDGTNCOC:Aa6G2ATGGA RHHITRKTIHHTTGGESKPKFPAFCDCIRICMRNFSSGDLTR KIHTHPRAPIPKPFCCGRRIKCFMARDNRFSSHRLSADRVHT THIRTHTGEKPFACDICGR LS TKIHLRKDAA KFAVRSRLRRH ZFP_HTT_PROM_68 LEGIHGVPAAMRAERSPEFCIRDNO:31 LARHIRTHTGEKP ICMRNFSRSDN CCGGCCGTGGACTCTGAG KHTKIHTGSKPFFACCRDIICCGRKFAWRGDRVSE IDNO:63 HKIRTHTGEKPFACDICGRMKRFNAFRSSDDRASLDALRSHRT TIHHTTGGESKPKFPAFCDCIRCIGCRMRNFSERGTLARHIR M_70 LLR LERGKID HHA IGA KFARSDDRKTHTKIH ZFP_HTT_PRO RVR TPHATAS GME EAKEPRI FPD AFN CDCO IR: CIGC3 RM2 KRFNAFDSRDSRDSLTS GTSCECCGIGDCANGOC:CCCC RHTKIHTGSKPFCRICMRN 64 HIRTHTGEKPFACD FSSSTRAR KIHTGSKPFCRIICCMGRRNKFFSAHRRSRDSTRLWSGEHHT FP_HTT_PROM_66 TLHELGRIHKGDVAPA IR Z RSE IDNO:33 LSR AAMAERPFCRICMRNFSDRSD GGTCCAAGATGGACGGCC SHTHKIIRHTTHTGEKPFACDICGRKFARRDTLRSE IDNO:65 HIRTHTGGESKPKFPAFCDCIRCIGCRMKRFNAFSRSDHLST KIHTGSKPFCRIC SAHRITHT THTGEKP MRNFSSGDLTRHIR _HTT_PROM_24 LFR CADCK IDD CIA GCAF RGRACD KRFKAFSICGRKFADRSHLARHTKIH ZFP DAE PRSKNWI LTD RLRLN HMO TH: KTIR3 HI4 THTGEKPFA GGCGCAGCGTCTGGGACGCAA PFACDICGRKFARVDVLLDHTRIRHPTGIEPPKSE IDNO:653 ACDICGRKFAWSNLRHTK KPF KPFACDICGRKFA IHTRPIPP FACDICGRKFAERSKKSLTRLRKHTTHKTIRHILHRTGGSEKP ZFP_HTT_PROM_25 FS CAE DCIDCII GCD RGKRN FKO AF:AR6K14TLTDHTRIHTGEKPFA TCTGGGACGCAAGGCGCCGTG PFACDICGRTKKFAYRLKSRHTKIHTRPIPPKSE IDNO:654 AKCDICGRKFAFPYLWLTRLRKHTHKTIRHITHTRGPEKIPPFP FPAFCADCIDCIGCRGKRFKAFTARKYHLSRHTRIHTGEKP SE IDNOSSSLCKHTKIHLRGS ZFP_HTT_PROM_26 : 615 FACDICGRKFALKHHLRDHTRIHT TCTGGGACGCAAGGCGCCGTG CDICGRKFATRYLSRHTKIHTRGPEKIPPFPAKSE IDNO:655 PAFCADCIDCIGCRGKRFKAFARKWTLSHTRIHTGEKPF KPFACDICGRFKPFYALRLKRYRHHLTLKRIHHTRPIPP FACDICGRKF TRIHTGEKP SE I ATSSSLCKHTKIHLRGS ZFP_HTT_PROM_27 FCADCIDCIGCD RGKRNKOF:AR6K16TLDHTRIHTGEKPFA TCTGGGACGCAAGGCGCCGTG PFACDICFGALRYYLRRHTKIHTRPIPPKSE IDNO:656 ACDICGRKRFKAFARRYKYWLTRLRKHTHTRIHTGEKPF KFPAFACDICGRKFARKYHLTKRIHHTTRIRHPTGIEPKPP P_HTT_PROM_28 FSC CAEDICGRKFASSSSLCKHTKIHLRGS ZF DCIDCII GCD RGKRN FKO AF: TAKR6K17 YLTSLRHDHTRIHTGEKPFA TCTGGGACGCAAGGCGCCGTG PFACDICGRKFARKWTLTKIHHTRPIPPKSE IDNO:657 ACDICGRKF TRIHTGEKPF K AFPYLLRRHTKIHTRPIPP FPAFCADCIDCIGCRGKRFKFARKYHLSRHTRIHTGEKP _29 FS CAE ATSSNLCKHTKIHLRGS ZFP_HTT_PROM DCIDCII GCD RGKRN FKO AF: FARR6 YK18 YLTRLRTHDTHKTIRHITHTRGPEKIPFA TCTGGGACGCAAGGCGCCGTG PFACDICGRKFARKWTLHTRIHTGEPKPKSE IDNO:658 ACDICGRKFAFRYYLRR PF KPFACDICG HTKIHTRPIPP FACDICGRKRFKAFTASRSKSDLHCLKRNHTRIHTGEKP SE IDNO:619HTKIHLRGS ZFP_HTT_PROM_30 FCADCIDCIGCRGKRFKAFTASSKNSLHRLRKHSTHKTIRHITHTRGPEKIPPFPAK CGSGEGACIGDGGNTCCAAGATGGAC PFACDICGRKFARK O:659 ACDIC WTLMHTRIHTGEKPF KPFACGDRIKCFGARYKSFAHDLPSSRNHTKIHTRPIPP FACDICGRKFARRYSLLLRLHRTHKTIRHILHRTGGEKP PROM_31 FSAECDIICDGRNKOF:AR6 S ZFP_HTT_ K20 CDI YHLHTRIHTGEKPFA GGCGGCTGAGGAAGCTGAGGA PFACCGDRKFARKFTLGHTKIHTRPIPPKSE IDNO:660 ACDICIGCRGKRFKAFRASSKNGLNLNRHTRIHTGEKPF KPFACDICGRKFATKRPHHLTTKRIHHTTRIRHPTGIPP FACDICGRKFAEKSKLR EKP SE IDNO:621RHTKIHLRGS ZFP_HTT_PROM_32 FCADCIDCIGCRGKRFKAFASTNKTLHRLRSHRTHKTIRIHTGEKPFA CATTGGCAGAGTCCGCAGGCT PFACDICGRKFADPSALIRHHTTRIRHPIPPKSE IDNO:661 ACDICGRKFASTHLR TGEKPF KPFACDICGR AHTKIHTRPIPP FACDICGRKFKAFHASRSKNDLHRLSRHNTHKTIRIHTGEKP T_PROM_33 FSAECDIICDGRN HLRGS ZFP_HT KOF:AR622 CDI KDHLRNHTRIHTGEKPFA AGGGCTGTCAATCATGCTGGC PFACCGDRIKCFGALKEYLSKHTKIHTRPIPPKSE IDNO:662 ACDICGRKRFKAFAYDSPSSLGWLKLHHTHKTIRIHTGEKPF KPFACDIGCRGKRFKAFRALL HTRPIPP FACDIC DKRLTRLTLHRTHKTIRHILHRTGGSEKP ZFP_HTT_PROM_34 FS CAE DCIDCII GCD RGKRN FKO AF: FA6 RSK2 KS3 LDRLRGHRTHKTIRHITHTRGPEKIPPFPAK CTSGECTTITTACCTGCGGCCCAG PFACDICGRKFARK D NO:663 ACDIC FTLLSHTRIHTGEKPF KPFACGDRIKCFGARCKPFSANYLKRHKVHLTRKIHTRPIPP FACDICGRKF DHTRIHTGEKP SE IDNARRSTLRAHTKIHLRGS ZFP_HTT_PROM_35 FCADCIDCIGCRGKRFKO AF: TAKE6K2 YR4 LTLLNHTRIHTGEKPFA TCCCCTCTCCGTTGAGCCCCG PFACDICGRKFAYKTFRVHLTRKIHTRPIPPKSE IDNO:664 ACDICGRKF RHTRIHTGEKPF KPF ATSSNLCKHTKIHTRPIPP FACADCIDCIGCRGKRFKAFTASRSSNGDLNRHTRIHTGEKP SE IDNO:62LAKHTKIHLRGS ZFP_HTT_PROM_36 FACDI 5 CDICGCRGKRFKAFASARKYRLTSLRRHNTHTRIHTGEKPFA GGCCCCGCCTCCGCCGGCGCA PF KIHTRPIPPKSE ID NO:665 ACADCIDCIGCRGKRFKAFWARRVRDSTLRDHTRIHTGEKPF KPFACDICGRKFAELKNRRTHLTMKNIHHTTRIRHPTGIEPP FACDICGRKFAFRSKLRRH KP _HTT_PROM_37 FS CAE TKIHLRGS ZFP DCIDCII GCD RGKRN FKO AF: LARR6 WV2 RD6 LVNLYLHTHKTIRHITHTRGEKPFA GGACGGGTCCAAGATGGACGG PFACDICGRKFARKWTLHTRIHPTGIEPKPPKFSE IDNO:666 AKCPDFIACCGDRIKCFGARTKSFSANRLCKHTKIHTRPIPP FACDICGRKFAHRPKHALHTLRRHDTHKTIRHILHRTGGSEKP SE IDNO:627 ZFP_HTT_PROM_38 FCADCIDCIGCGRKFARKAHLRDHTRIHTGEKPFA AGCCCCATTCATTGCCCCGGT PFACDRIKCFGADRSTLRHTKIHTRPIPPKSE IDNO:667 ACDICGRKRFKAFTASYSKHHLVGLHRHNTHTRIHTGEKPF KPAFACDICGRK KIHTRPIPP F FAEKRSLLNHTRIHTGEKP T_PROM_39 FSCEDICIGDRKNFATKYLSRHTKIHLRGS ZFP_HT O:628 CADCIDCIGCRGKRFKAFASLRKYLTSLRHNTHKTIRHITHTRGPEKPFA GGAAAAGCTGATGAAGGCCTT PFACDICGRKFARKFTLHTRIHTGIEPKPKSE IDNO:668 ACDICGRKFARKFILGHT PF KPFACDICGRKF KIHTRPIPP FACDICGRKFAARAKHSLNTLRNHTTHKTIRHILHTGEKP _PROM_40 FSAECDIICDGRNKOF: RGS ZFP_HTT AR6K29 CD WNLSMHTRIHTGEKPFA TCAAGTCCTTCCAGCAGCAGC PFIACCGDRKFARKWNLRMHTKIHTRPIPPKSE IDNO:669 ACDICIGCRGKRFKAFTAPNKASLDSLYGRHTRIHTGEKPF KPFACDICG HTKIHTRPIPP FA RKFARKTLNHTRIHTGEKP T_PROM_41 FSC CAEDIC DCIDCIIG GCDRK RGKRNF FKOASSSLYKHTKIHLRGS ZFP_HT AF: RARY6 YP3 SY0 LLSLDRHRTHKTIRHIHTGEKPFA CGCCTTCGCCCGGGTGGGGCG PFACDICGRKFARKAHLRDHTTRIRHPIPPKSE IDNO:670 ACDICGRKFAHYKS TGEKPF KPFACD LWRHTKIHTRPIPP FACDICIGCRGKRFKAFLARYYKYHLVRLRSHTRIHTGEKP SE IDNO:631RHTKIHLRGS ZFP_HTT_PROM_42 FCADCIDCIGCRGKRFKAFYARLFKVLTRLSHRTHKTIRHITHTRGPEKIPPFPAK GCSGECTGITDCANGOC:GG6C7C1TTGCTG PAFCADCIDCIGCRGKRFKAFRARKAHLRDHTRIHTGEKPF KPFACDICGRKKFWANRLKSGMTHLTKDIHHTTRIRPIPP FACDICGRKFARRT HTGEKP SE IDNO:6TLRDHTKIHLRGS ZFP_HTT_PROM_43 FCADCIDCIGCRGKRFKAFASRNK3 TD2 LHLRNHTRIHTGEKPFA CAGAACCTGCGGGGGCAGGGG PFACDICGRKFARKRDRHHLTKIHTRPIPPKSE IDNO:672 ACDICGRKFALKEYLRKRHNTHKTIRHITHTRGPEKIPPFP KFPAFCADCIDCIGCRGKRFKAFADPSNLNRHTRIHTGEKP SE IDNRKWNLKMHTKIHLRGS ZFP_HTT_PROM_44 F O:633 CADCIDCIGCRGKRFKAFRARRDKRDLRRLKRHDTHKTIRHITHTRGPEKIPPFPAK CGSGECGTIGDGCNCOCCGCCTCCGCC PFACDICGRKFARRST : 673 ACDICGR LRDHTRIHTGEKPF KPFACDIKCFGARDKRFSATLLKRHRHHLTRKDIHHTRPIPP FACDICGRKFAS TRIHTGEKP SE IDNO:RYLRRHTKIHLRGS ZFP_HTT_PROM_45 FCADCIDCIGCRGKRFKAFHAKR6 PK3 HS4 LTLRDHTRIHTGEKPFA CGGCGCCGCGAGTCGGCCCGA PFACDICGRKFARKTRTHLTKTIHHTRPIPPKSE IDNO:674 ACDICGRKFAR TRIHTGEKPF KPFA RGTLRDHTKIHTRPIPP FACDCIDCIGCRGKRFKAFASARKYRLNRLRDHTRIHTGEKP SE IDNO:635RHTKIHLRGS ZFP_HTT_PROM_46 FCADCIDCIGCRGKRFKAFRARDGRTSLTRLDRHNTHTRIHTGEKPFA GGGAGACCGCCATGGCGACCC P KIHTRPIPPKSE ID NO:675 AFCADCIDCIGCRGKRFKAFTAKAKYLNSLNHTRIHTGEKPF KFPAFACDICGRKFAKSRHHLTKKTIHHTTRIRHPTGIEPKPP TT_PROM_47 FSCEDICIGDRKFARRSHLRDHTKIHLRGS ZFP_H NO:636 CADCIDCIGCRGKRFKAFTASSKGSLDSLKGHRTHKTIRHITHTRGPEKPFA GGCCTTCATCAGCTTTTCCAG PFACDICGRKFARKDRLMKHTRIHTGIEPPKSE IDNO:676 ACDICGRKFATSSGLCHH KPF KPFACDICGRK TKIHTRPIPP FACDICGRKFAFEARYSKKHLVRLRRHATHKTIRHIHTGEKP _PROM_48 FSAECDIICDGRNKO LRGS ZFP_HTT F:AR6R37 CDI DRLRDHTRIHTGEKPFA TCGCCATGGCGGTCTCCCGCC PFACCGDRIKCFATSSNLCKHTKIHTRPIPPKSE IDNO:677 ACDICGRGKRFKAFEARLSKKHLHRLRSHRTHTRIHTGEKPF KPFACDICGRKF KIHTRPIPP FAC ARKGDLNRHTRIHTGEKP PROM_49 FS CAEDIC DCIDCIIG GCDRK RGKRNF FKOA AF:TRYLRTHTKIHLRGS ZFP_HTT_ EAKY6 SP3 KY8 LLRLRRHNTHKTIRHITHTRGPEKIPPFA CGGCAGTCCCCGGAGGCCTCG PFACDICGRKFARKAHLRDHTRIHTGEKPPKFSE IDNO:678 AKCPDFIACCGDRIKCFGARDKRFSATRLRHTKIHTRPIPP FACDICGRKFASRKYWLNSLRKHMTHKTIRHILHRTGGSEKP ZFP_HTT_PROM_50 FS CAE DCIDCII GCD RGKRNKOF:AR6R3G9DLNRHTRIHTGEKPFA ACTCGCGGCGCCGCTCAGCAC PFACDICFGARKSFNDLRKHTKIHTRPIPPKSE IDNO:679 ACDICGRKFARARRTKTYLDRLDKHMTHKTIRHITHTGEKPF KPFACDICGRKFAYP RPIPP FACDIC YLLRHHTRIHTGEKP _51 FS GRKFAHSTLRNHTKIHLRGS ZFP_HTT_PROM E IDNO:640 CADCIDCIGCRGKRFKAFRARHTKHRLSRLDIHDTHKTIRHITHTRGPEKIPPFPAK CGSGGGCAATGAATGGGGCTCT PFACDICGRKF E IDNO:680 ACDI ALKTLVHTRIHTGEKPF KPFACCGDRIKCFGARRKRFSASFLPRYTLHLTKIHTRPIPP FACDICGR RRHTRIHTGEKP SE KFARRYSLSRHTKIHLRGS ZFP_HTT_PROM_52 FCADCIDCII GCD RGKRN FKO AF:ASR6K41CLNRHTRIHTGEKPFA CGCAGGTAAAAGCAGAACCTG PFACDICGRKFSANFLPRYRHTKIHTRPIPPKSE IDNO:681 ACDICGRKFASGNLLRLTRHRTHKTIRHITHTRGPEKIPPF KPFACDICGRKFARKYHLKH P FACDICGRKFAF TRIHTGEKP S CAE DCIDCII GCD RGKRNPYLLRRHTKIHLRGS ZFP_HTT_PROM_53 F FKO AF: DAPR6 SK4 NW2 LDRLRRHMTHKTIRHITHTRGPEKIPPFPAK GGSCECGTICDCANTCTTGGACCCGT PFACDICGRKFAYKHV O:682 ACDICGR LRDHTRIHTGEKPF KPFACDIKCFGARHKAFSANRLKRATHLTTKDIHHTRPIPP FACDICGRKFAF TRIHTGEKP SE IDNORSKLRRHTKIHLRGS ZFP_HTT_PROM_54 FCADCIDCIGCRGKRFKAF: RARR6 TK43 TLDRLRHTRIHTGEKPFA CGGCAGCCCCCACGGCGCCTT PFACDICGRKFADPSDNHLTLKIHTRPIPPKSE IDNO:683 ACDICGRKF RHTRIHTGEKPF KPF ADRSTLRHTKIHTRPIPP FACADCIDCIGCRGKRFKAFASRRKYWNLRTHTRIHTGEKP SE IDNO:64LSRHTKIHLRGS ZFP_HTT_PROM_55 4 FACDICGRKFARKYHLRHTRIHTGE AGACGCTGCGCCGGCGGAGGC CDICGRKFAVLRYLTRHTKIHTRPKIPPFPAKSE IDNO:684 PAFCADCIDCIGCRGKRFKFARCDTLLDHTRIHTGEKPF KPFACDICGARRKRFTATCLKRRDNHLTLKNIHTRPIPP FACDICGRK HTRIHTGEKP SE FALVEYLRKHTKIHLRGS ZFP_HTT_PROM_56 FCADCIDCII GCD RGRNKOF:A6K4S5DLGRHTRIHTGEKPFA AGGCGGGGCCACGCCGGCCAG PFACDIKCFGASRYLSRHTKIHTRPIPPKSE IDNO:685 ACDICGRKRFKAFDARRSKTYLTRLRRLHTRIHTGEKPF KPFACDICGRKFARKAHHLTRKDIHHTTRIRHPTGIEPKP FACDICGRKFASRYLTRH P P_HTT_PROM_57 FS CAE TKIHLRGS ZF DCIDCII GCD RGKRN FKO AF: HAGH6 PK4 HR6 LSLIDHTRIHTGEKPFA CAGCCCTAGCCTGCGGACTCT PFACDICGRKFARKTFRTHTKIHTRPIPPKSE IDNO:686 ACDICGRKFATKYLSLRHSTHKTIRHITHTRGPEKIPPF KPFACDICGRKFAEKRTLL P FACDICGRK NHTRIHTGEKP M_58 FS FARKWNLRMHTKIHLRGS ZFP_HTT_PRO CAE DCIDCII GCD RGKRN FKO AF: HAYR6 KR4 SD7 LRWLRRHDTHKTIRHITHTRGPEKPFA TGGCCAGGGAACCAGCCCGCC PFACDICGRKFAHHSTLRNHTRIHTIPPKSE IDNO:687 ACDICGRKFARAHL GEKPF KPFACDI TRHTKIHTRPIPP FACDICGCRGKRFKAFRARTKHSLDRLGGRHTRIHTGEKP SE IDNO:648HTKIHLRGS ZFP_HTT_PROM_59 FCADCIDCIGCRGKRFKAFFAPRYKLWLTRLRKHTHKTIRHITHTRGPEKIPPFPAK GTSTECTGICDCTNCOACACAGCAAGG PFACDICGRKFASGTL : 688 ACDICGR FNHTRIHTGEKPF KPFACDIKCFGARSKFSAGRLKWFHTHLTLKIHTRPIPP FACDICGR GHTRIHTGEKP S KFAVSTSLSPHTKIHLRGS ZFP_HTT_PROM_60 FCAE DCIDCIICDGRNKOF:AE6K4R9TLLNHTRIHTGEKPFA CCGCTGACAGCGCAGCGCCCC PFACGDRKFARRTTLRDHTKIHTRPIPPKSE IDNO:689 ACDICIGCRGKRFKAFRAKAWKNRLTLLHHTRIHTGEKPF KPFACDICGRKFARKRGMTHLTKDIHHTTRIRHPTGIPP FACDICGRKFARRSTLR EKP SE IDNO:650DHTKIHLRGS ZFP_HTT_PROM_61 FCADCIDCIGCRGKRFKAFWAALSKSLTSLAHVTHKTIRIHTGEKPFA GGGCGTGGTGAGACTGTAATG PFACDICGRKF HTRPIPPKSE ID NO:690 ACDICGRKFAVKRRLLNHTRIHTGEKPF KPFACDICGARRSTLRNHTKIHTRPIPP FACDICGRRKFARKTLTDHTRIHTGEKP SE IDKNFOA:RR6T5H1LRDHTKIHLRGS ZFP_HTT_PROM_64 LLESGRIHHIGRVTPHATAGMEAKEPRFPAFCDCIRCIGCRMKRNFSRSDD GCTGCGCCGGCGGAGGCG KHTKIHTGSKP FARNDNRTSE ID NO:691 HIRTHTGEKPFFCRICMRNFSRSDDLTR KIHTGSKPFACDICGRKFARSDDRKTHT THTGEKPFACRICMRNFSRSDDLTRHIR LRKDAARGCSDICGRKFASSDLRRHTKIH SE IDNO:652 -- , . .., , - - . , , , , , , - - , . , , , . , TALE_HTT_PROM_1 PLAAVDLRTLGYS EKIKPKVRSTVAHHEALVGHGFTHAHIVA GCGCTGTCAGCGGCCTTGCT LSTVHAPAALGTVAVKYDMIAALPEATHEAIVGVGKWSGARALEALSE IDNO:692 NLTPGEELVRVGAPIPALSNLHDGTGGKLALKIAKRGGVTAVEAVHAWRNALTGAPL HDGGKALETVRLLPVLCLEATHVGLRTLPLEPVVLVCAIAAHSGNLHTPEVVAIAS RLLPVLCAHGLTPEVVAIAS GGKALETV TPEVVAIA HDGGKALETVRLLPVLCAHGL GGKALETVSNRGLGLGPKVLACLEATHVGLRTLPLEPVVLVCAHGLTPEVVAIASNH LPVLCAHGLTPEVVAIASHDGGKALAEITAVSNRGLGLGPKVLACLEATHVGLRTLP EKVAVLAEITAVSNRILGLGPKVLACLEATHVGLRLLPVLCAHGLTPEVVAIASNHGG VLCAHGLTPEVVAIASNHTGPGEKVAVLAEITAVSHRDLGLGPKVLACLEATHVGRLLP VVAIASNHGGKALETVRLLPVLCAH LTPE ALETVRLLPVLCAH GLTPEVVAIASHDGGK CAHGLTPEVVAIASGNLGTGPGEKVAVLAEITAVSHRDLGLGPKVLACLEATVRLLPVL AIASNGGGKALETVRLLPVLC HGLTPEVV ETVRLLPVL AHGLTPEVVAIASNHGGKAL AHGLTPEVVCAIAAHSGNLGTGPGERPVAVLAEISAISVHADGLGSKALETVRLLPVLC LACLGGRPALDAV RPDPALAALTNDHLVA SE I KKGLPHAPALIKRTNRRIPERTSHRVA TALE_HTT_PROM_2 PLASAVHDPLARD ATLLN GGO TYVS:714 AVKYEDKMIIKAPAKLVPRESATTVHAEAHIHVEGAVLGVKGHWGSFTHAHIVA GTCAGCGGCCTTGCTGTGT LTVAGELRGPPLLDTGLLKIAKRGGVTAVEAVHAWRGNAARLATLGEALSE IDNO:693 NLTPEVVAIASNHGGKALETVRLLPV APL NGGGKALETVRLLPV LCAHGLTPEVVAIAS RLLPVLCAHGLTPEVLVCAIAAHSGNLITGPGEKVAVLAEITAVSHRDLGLGPKALETV TPEVVAIASNHGGKALETVRLL VLCAHGL GGKALETVRL PVLCAHGLTPEVVAIASHD LPVLCAHGLTPLEPVVLVCAIAAHSGNLHTGPGEKVAVLAEITAVSNRHGGKALETVRL EVVAIASHDGGKALETV LLPVLCAHGLTP KALETV RLLPVLCAHGLTPEVVAIASHDGG VLCAHGLRTLPLEPVVLVCAIAAHSGNLGTGPGEKVAVLAEITASNGGGKALETVRLLP VVAIASNHGGKALE VRLLPVLCAHGLTPE AL TVRLLPVLCAHGLTPEVVAIASHDGGK CEATHVGLRTLPLEPVVLVCAIAAHSGNLHTGPGEKVAVAIASNGGGKALETVRLLPVL AIASNGGGKALETVRLLPVLCLEATHVGLRTLPLEPVVLVCAIAAHSGNLHTGPGEKVV ETVRLLPVLCAHGLTPEVVAIASNGGG AL ALAALTNDHLVALAC RPALESIVALSRPDP TSHRV LGGRPALDAVKKGLPHAPALIKRTNRRIPER TALE_HTT_PROM_3 PLAS SAEA VHDPLI ARD ATLLN GGO TYVS:715 AVKYEDKMIIKAPAKLVPRESATTVAHHEALVGHGFTHAHIVA GCTGTGTGAGGCAGAACCT L HEAIVGVGKWSGARALEALSE IDNO:694 NTLVTAPGEELVRVGAPIPALSNLHDGTGGKLLKIAKRGGVTAVEAVHAWRNALTGAPL HDGGKALETVRLLPVLACLEATHVGLRTLPLEPVVLVCAIAAHSGNLGTGPEVVAIAS RLLPVLCAHGLTPEVVAIASNH GKALETV TPEVVAIASNG GGKALETVRLLPVLCAHGL GGKALETVRLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHSGNLTPEVVAIASNH LPVLCAHGLTPEVVAIAS GGGKALETVRL EVVAIAS NHGGKALETVRLLPVLCAHGLTP KALETVNRILGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHGLTPEVVAIASNHGG VLCAHGLTPEVVAI SNHGGKALETVRLLP VVAI ASHDGGKALETVRLLPVLCAHGLTPE ALETAVSNRILGLGPKVLACLEATHVGLRTLPLEPVVLVCAAHGLTPEVVAIASNHGGK CAHGLTPEVVAIASNIGGKALEITAVSNRILGLGPKVLACLEATHVGLRTLPLEPVVLV AEITAVSHRDLGLGPKVLACLEATHVGRLLPVLCAHGLTPEVVAIASHDGGKAL ALAALTNDHLVALACLLTGPGERPVAVLADIAAVSKNGGGRPALESIVALSRPDP TS KGLPHAPALIKRTNRRIPER SHRVA TALE_HTT_PROM_4 PLASAEVHDPLI ARD ATLLN GGO TYVS:716 AVKYEDKMIIKAPAKLVPRESATTVHAEAHIHVEGAVLGVKGHWGSFGTAHRAAHLIEVAAL GCSGEGGGIGDCANGGOG:GC6G9G5GCT LNTLVTAPGEELVRVGAPIPALSLDTGLLKIAKRGGVTAVEAVHAWRNALTGAPL HDGGKALETVNRHLGLGPKVLACLEATHVGLRTLPLEPVVLCAHGLTPEVVAIAS RTLPLEPVVLVCAIAAHSGNLHTGPGEKVAVLAEITAVSNRHLGLGPKVLAV CLAEITAVSNRHLGLGPKVLACLEATHVGL GGKALETVRLLP AHGLTPEVVAIASNH LPVLCAHGLTPEVVLVCAIAAHSGHLDTGPGEKVAVLAEITASNHGGKALETVRL EKVVAIASNIGGKALETVRLLPVLCAHVGLRTLPLEPVVLVCAIAAHSGNLHTGPG VLACLEATHVGLRTLPLEPVVLVCAIAAHGLTPEVVAIASNHGGKALETVRLLP VVAIASNHGGKALETVSNRHLGLGPKVLACLEATHVGLRTLPLPVLCAHGLTPE ALETVRLLPVLCAHG EVVAIASHDGGK CA LTPEVVAIASNHGGKALETVRLLPVL AIAHSGNLHTGPGEKVAVLAEITAVSNRHLGLGKALETVRLLPVLCAHGLTPEVV ETVRLLPVLCAHGLTPEPVVLVCAIAAHSGNLGTGPGERPVAVLAIASHDGGKAL ALAALTNDHLVALACLGGRPALDAVKKGLPHAPAELSIIKVRATNLRSRRIPDP TSH PER TALE_HTT_PROM_5 PLAS SAERVA VHDPLI ARD ATLLN GGO TYVS:717 AVKYEDKMIKPKVRSTVAHHEALVGHGFTHAHIVA GCCCCCGCAGGTTCTGCCT LTVAGELRGPPLLDTGILALALPEATHEAIVGVGKWSGARALEALSE IDNO:696 NLTPEVVAIASNHGGKALKEITAVKRRGLGLVPTVALVCEAVHAWRNALTGAPL HDGGKALETVRLLP AHGLTPEVVAIAS RL VLCAHGLTPEVVAIASHDGGKALETV TPLEPVVLVCAIAAHSGHLDTGPGEKVAVLAIASHDGGKALETVRLLPVLCAHGL GGKALETVRLLPVLCEATHVGLRTLPLEPVVLVCAIAAHSGNLHTPEVVAIASHD LPVLCAHGLTPEVVAIA GGKALETVRL EVV SHDGGKALETVRLLPVLCAHGLTP KALAEITAVSNRILGLGPKVLACLEATHVGLRLLPVLCAHGLTPEVVAIASNHGG VLCAHGLTPEVVAIASNGTGPGEKVAVLAEITAVSNRHLGLGPKVLALETVRLLP VVAIASNGGGKALETVRLL CAHGLTPE ALETVR PVLCAHGLTPEVVAIASHDGGK CAHGLTLPLEPVVLVCAIAAHSGNLHTGPGEKVAVAIASNGGGKALETVRLLPVL AIASHDGGKALETVRLLPVLCLEATHVGLRTLPLEPVVLVCAIAAHSGHLTPEVV ETVRLLPVLCAHGLTPEVVAI DGGKAL ALAALTN ASNGGGRPALESIVALSRPDP TS DHLVALACLGGRPALDAVKKGLPHAPALIKRTNRRIPER SHERVAIDNO:718 TALE_HTT_PROM_6 PLASAVHDPLARATLLGGTYVSAVKYEDKMIIKAPAKLVPRESATTVHAEAHIHVEGAVLGVKGHWGSFGTAHRAAHLIEVAAL GGSTETCCCTGGCCAGCCAT LTVAGELRGPPLLDTGLLKIAK IDNO: 697 NLTPEVVA RGGVTAVEAVHAWRNALTGAPL NHGGKALEITAVSNRHLGLGPKVLACLEATHVGLRTLPLEPVVLVCAAHGLTPEVVAIAS RLLPVLCAHGLTPEVV IASNGGGKALETV TPEVV AIASNGGGKALETVRLLPVLCAHGL GGKALAEITAVSHRDLGLGPKVLACLEATHVGLRTLPLEPVVLVCAHGLTPEVVAIASHD LPVLCAHGLTPEVV AIASHDGGKALETVRL EVV AIASNGGGKALETVRLLPVLCAHGLTP KALAEITAVSNRHLGLGPKVLACLEATHVGLRTLPLEPVVLVCAHGLTPEVVAIASNHGG VLCAHGLTPEV AIASHDGGKALETVRLLP V VAIASHDGGKALETVRLLPVLCAHGLTPE AVLAEITAVSNRILGLGPKVLACLEATHVGLRTLPLEPVVLCAHGLTPEVVAIASNHGGK CAHGLTPEVVAIASHDGGKAVLAEITAVSHRDLGLGPKVLACLEATHVGLRTLPLEPVVL AIASNIGGKALETVRLLPVLCAHGLTPEV V ESIVALSRPDPALAALT VAIASNGGGRPAL LI NDHLVALACLGGRPALDAVKKGLPHAPA E_HTT_PROM_7 PLASK SAERTN VHDPLIR ARDRI ATLLNPERTSHRVA TAL GGO TYVS:719 AVKYEDKMIIKAPAKLVPRESATTVHAEAHIHVEGAVLGVKGHWGSFGTAHRAAHLIEVAAL GGSTETCCICDTGNGCCAGCCATT LTVAGELRGPPLLDTGLLKIAKRGG O: 698 NLTPEVVAIAS VTAVEAVHAWRNALTGAPL NHGGKALETVNRHLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHGLTPEVVAIAS RLLPVLCAHGLTPEVVAIA SNGGGKALETV TPEVVAIA SNGGGKALETVRLLPVLCAHGL GGKALETVSHRDLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHGLTPEVVAIASHD LPVLCAHGLTPEVVAIA SHDGGKALETVRL EVVAIA SNGGGKALETVRLLPVLCAHGLTP KALETVSNRHLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAHGLTPEVVAIASNHGG VLCAHGLTPEVVAI ASHDGGKALETVRLLP VVAI ASHDGGKALETVRLLPVLCAHGLTPE ALETAVSNRILGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAHGLTPEVVAIASNHGGK CAHGLTPEVVAI ASHDGGKALETVRLLPVL AI ASHDGGKALETVRLLPVLCAHGLTPEVV ETAVSNRILGLGPKVLACLEATHVGLRTLPLEPVVLVCAAHGLTPEVVAIASNGGGKAL ALAALTNDHLVALACLGGRPALDIAAVSKNKGGGLGPRHPAAPLAELSIIKVRALSRPDP TSH TNRRIPER TT_PROM_8 PLASRVA TALE_H SAEVHDPLI ARD ATLLN GGO TYVS:720 AVKYEDKMIIKAPAKLVPRSTVAHHEALVGHGFTHAHIVA GGCCAGCCATTGGCAGAGT LTVAGELRGPPLLDTGLLKIAEKARTGHGEVATIVGVGKWSGARALEALSE IDNO:699 NLTPEVVAIASNH AVEAVHAWRNALTGAPL NH GGKALETVRLLPVLCAHGLTPEVVAIAS RLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHSGHLDTPEVVAIASHDGGKALETV TPEVVAIASNIGGKALETVRLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHSGNLH GLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHGLTPEVVAIASHDGGKALETVRL EVVAIASNIGGKALETVSHRDLGLGPKVLACLEATHVGLRTLPLEPVVLVCAAHGLTP KALETVRLLPVLCAHGLTPEVV IASNGGG VLCAHGLTPEV AIASNGGGKALETVRLLP VVAIASNHGGKAVLAEITAVSNRHLGLGPKVLACLEATHVGLRTLPLPVLCAHGLTPE ALETVRLLPVLCAHGLT EVVAIASHDGGK CAHGL PEVVAIASNIGGKALETVRLLPVL AIASNITGPGEKVAVLAEITAVSNRHLGLGPKVLACLEATHVRLLPVLCAHGLTPEVV ETVRLLPVLCAHGLTPEVVAIASGNLGTGPGERPVAVLAEISAISVNAHGLGSKRPAL ALAALTNDHLVALACLGGRPALDAVKK DP TS GLPHAPALIKRTNRRIPER TALE_HTT_PROM_9 PSHERVAID LASAVHDPLARATLLN GGO TYVS:721 AVKYEDKMIIKAPAKLVPRESATTVHAEAHIHVEGAVLGVKGHWGFTHAHIVA GCGGACTCTGCCAATGGCT LTVAGELRGPPLLDTGLLKIAKRGGVTAVEAVHAWSRGNAARLALEALSE IDNO:700 NLTPEVVAIASNHGGKALETVRLL TGAPL HDGGKALETVRL PVLCAHGLTPEVVAIAS RLLPVLCAHGLTPLEPVVLVCAIAAHSGNLHTGPGEKVAVLAEITAVSNHGGKALETV TPEVVAIASNIGGKALET RLLPVLCAHGL GGKALE VRLLPVLCAHGLTPEVVAIASHD LPVLCATHVGLRTLPLEPVVLVCAIAAHSGHLDTGPGEKVAVAIASNGGGKALETVRL EKVVAIASNGGGKALETVRLLPVLCLEATHVGLRTLPLEPVVLVCAIAAHSGNLHTGPG VLACLEATHVGLRTLPLEPVVLVCAIAAHSGHLTPEVVAIASHDGGKALETVRLLP VVAIASNIGGKALETVRDLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHGLTPE ALETVRLLPVLCAHGLTPEVVAI SNIGGK CAHGLTPEVVA ASNGGGKALETVRLLPVL AIASNHGGKALEITAVSNRHLGLGPKVLACLEATHVGLRTLPLEPVVLCAHGLTPEVV ETVRLLPVLCAHGLTPE VAIASHDGGKAL ALAA VVAIASNGGGRPALESIVALSRPDP TSLTNDHLVALACLGGRPALDAVKKGLPHAPALIKRTNRRIPER TALE_HTT_PROM_10 PSHERVAIDNO:722 LASAVHDPLARATLLGGTYVSAVKYEDKMIIKAPAKLVPRESATTVHAEAHIHVEGAVLGVKGHWGSFGTAHRAAHIVA AGCCTGCGGACTCTGCCAAT LTVAGELRGPPLLDTGLLKIAKRGGVTAVEAVHAWRNALTLGEAAPLLSE IDNO:701 NNLHTGPGEKVAVLAEITAVSNRILGLGPKVLACLETVRLLPVLCAHGLTPEVVAIAS RLLPVLCAHGLTPEVVAIAAHSGHLDTGPGEKVAVLAEITAVSHRDLGLGPKVALETV TPEVVAIASNGGGKALETVRLLP LCAHGL GGKALETVRLL VLCAHGLTPEVVAIASNH LPVLCAHGLTPEPVVLVCAIAAHSGNLHTGPGEKVAVLAEITAVSHRDGGKALETVRL EVVAIASNHGGKALETV LLPVLCAHGLTP KALET RLLPVLCAHGLTPEVVAIASNIGG VLCAHVGLRTLPLEPVVLVCAIAAHSGNLGTGPGEKVAVLAIASHDGGKALETVRLLP VVAIASHDGGKALETVRLLPVLCEATHVGLRTLPLEPVVLVCAIAAHSGNLGTGPGEK ACLEATHVGLRTLPLEPVVLVCAIAAHSGHLDTPEVVAIASNHGGKALETVRLLPVL AIASHDGGKALETVRLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHGLTPEVV ETVRLLPVLCAHGLTPEVVA SNIGGKAL AHGLTPEVV IASNIGGKALETVRLLPVLC LACLGGRPALADIAAVSKNKGGGLGPRHPAAPLAELSIVALSRPDPALAALTNDHLVA ALE_HTT_PROM_11 PLAS SAEVHDPLI ARD IKRTNRRIPERTSHRVA T ATLLN GGO TYVS:723 AVEKIKPKVRSTVAHHEALVGHGFTHAHIVA AGGGCTGTCAATCATGCT LTVAGELRGPPLKLYDTDGMIAALPEATHEAIVGVGKWSGARALEALSE IDNO:702 NLTPEVVAIASNIGGKLALLKEITAVKRRGLGLVPTVALVCEAAVHHAWRNALTGAPL NHGGKALETVRLLPVLC GLTPEVVAIAS RLLPVL AHGLTPEVVAIASNHGGKALETV TPEVVCAIAAHSGHLDTGPGEKVAVLAEITAVSNRHLGLGKALETVRLLPVLCAHGL GGKALETVRLLPVLCAHGLTPEPVVLVCAIAAHSGNLHTGPGEKVAVLAEITAVSNG LPVLCAHGLTPEVVAIASNGGGKALET RL EVVAIASHDGGKALE VRLLPVLCAHGLTP KALETVRLLPVLCATHVGLRTLPLEPVVLVCAIAAHSGNLITGPGEKVVAIASNIGG VLCAHGLTPEVVAIASNGGG ALETVRLLP VVAIASHDG KALETVRLLPVLCAHGLTPE ALETVRLLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHSGLTPEVVAIASNIGGK CAHGLTPEVVAIA NGGGKALETVRLLPVL AI SNHGGKALETVRLLPVLCAHGLTPEVV ESAISVHADGLGSKRPADLPEATLVAARLLTLPVLCAHGLTPEVVAIASNGGGRPAL LI NDHLVALACLGGRPALDAVKKGLPHAPA ALE_HTT_PROM_12 PSKERTNIRRIPERTSHRVA T D NO:724 LASAVHDPLARATLLGGTYVSAVKYEDKMIIKAPAKLVPRESATTVHAEAHIHVEGAVLGVKGHWGSFGTAHRAAHLIVA CAATCATGCTGGCCGGCGT LTVAGELRGPPLLDTGLLKIAKRGGVTAVEAVHAWRNALTGEAAPLLSE IDNO:703 NNLITGPGEKVAVLAEITAVSHRDLGLGPKVLACLETVRLLPVLCAHGLTPEVVAIAS RLLPVLCAHGLTPEVVAIAAHSGNLGTGPGEKVAVLAEITAVSNRILGLGPKALETV TPEVVAIASHDGGKALETVRLL VLCAHGL GGKALETVRL PVLCAHGLTPEVVAIASNI LPVLCAHGLTPLEPVVLVCAIAAHSGNLHTGPGEKVAVLAEITASNGGGKALETVRL EVVAIASHDGGKAL VRLLPVLCAHGLTP KA ETVRLLPVLCAHGLTPEVVAIASNGGG VLCLEATHVGLRTLPLEPVVLVCAIAAHSGNLHTGPEVVAIASNHGGKALETVRLLP VVAIASHDGGKALETVRLLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHSGHLTPE ALETVRLLPVLCAHGLTPEVVAIA DGGK CAHGLTPEVVAI SNHGGKALETVRLLPVL AIASHDGGKALETAVSNRHLGLGPKVLACLEATHVGLRTLPLEPVVLVCAHGLTPEVV ETVRLLPVLCAHGLTPE AIASNHGGKAL ALAA VVAIASNGGGRPALESIVALSRPDP TSLTNDHLVALACLGGRPALDAVKKGLPHAPALIKRTNRRIPER SHERVAIDNO:725 TALE_HTT_PROM_13 PLASAVHDPLARATLLGGTYVSAVKYEDKMIIKAPAKLVPRESATTVHAEAHIHVEGAVLGVKGHWGSFGTAHRAAHLIEVAAL GASTTGACAGCCCTAGCCT LTVAGELRGPPLLDTGLLKIA E IDNO: 704 NLTPEVV KRGGVTAVEAVHAWRNALTGAPL NIGGKALAEITAVSNRHLGLGPKVLACLEATHVGLRTLPLEPVVLVCAHGLTPEVVAIAS RLLPVLCAHGLTPEVV AIASNGGGKALETV TPEVV AIASNGGGKALETVRLLPVLCAHGL GGKALAEITAVSNRHLGLGPKVLACLEATHVGLRTLPLEPVVLVCAHGLTPEVVAIASNI LPVLCAHGLTPEVV AIASHDGGKALETVRL EVV AIASNIGGKALETVRLLPVLCAHGLTP KALAEITAVSNRHLGLGPKVLACLEATHVGLRTLPLEPVVLVCAHGLTPEVVAIASHDGG VLCAHGLTPEV AIASHDGGKALETVRLLP V VAIASHDGGKALETVRLLPVLCAHGLTPE AVLAEITAVSNRGLGLGPKVLACLEATHVGLRTLPLEPVVLCAHGLTPEVVAIASNIGGK CAHGLTPEVVAIASHDGGKAVLAEITAVSNRHLGLGPKVLACLEATHVGLRTLPLEPVVL AIASHDGGKALETVRLLPVLCAHGLTPEV V ESIVALSRPDPALAALT VAIASNGGGRPAL LI NDHLVALACLGGRPALDAVKKGLPHAPA _HTT_PROM_14 PLASK SAERTN VHDPLIR ARDRI ATLLNPE GGORTSHRVA TALE TYVS:726 AVKYEDKMIIKAPAKLVPRESATTVHAEAHIHVEGAVLGVKGHWGSFGTAHRAAHLIEVAAL GGSCECGGICDGTNGGCCCCGCCT LTVAGELRGPPLLDTGLLKIAKRGG O: 705 NLTPEVVAIAS VTAVEAVHAWRNALTGAPL NHGGKALETVNRHLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHGLTPEVVAIAS RLLPVLCAHGLTPEVVAIA SHDGGKALETV TPEVVAIA SHDGGKALETVRLLPVLCAHGL GGKALETVSNRHLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHGLTPEVVAIASNH LPVLCAHGLTPEVVAIA SHDGGKALETVRL EVVAIA SNHGGKALETVRLLPVLCAHGLTP KALETVSNRGLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHGLTPEVVAIASNHGG VLCAHGLTPEVVAIA SNHGGKALETVRLLP VVAIA SHDGGKALETVRLLPVLCAHGLTPE ALETVSHRDLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHGLTPEVVAIASHDGGK CAHGLTPEVVAIA SHDGGKALETVRLLPVL AIA SNHGGKALETVRLLPVLCAHGLTPEVV ETVSHRDLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAHGLTPEVVAIASHDGGKAL ALAALTNDHLVALACLGGRPALDAAVSKNKGGGLGPRHPAAPLAELSIIKVRATLSRPDP TS NRRIPER T_PROM_15 PLASH SAERVA TALE_HT VHDPLI ARD ATLLN GGO TYVS:727 AVKYEDKMIIKAPAKLVRSTVAHHEALVGHGFTHAHIVA CCGCCGGCGCGGCCCCGCCT LTVAGELRGPPLLDTGLLKIPAEKARTGHGEVATIVGVGKWSGARALEALSE IDNO:706 NLTPEVVAIASHD AVEAVHAWRNALTGAPL HD GGKALETVRLLPVLCAHGLTPEVVAIAS RLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHSGHLDTPEVVAIASNHGGKALETV TPEVVAIASHDGGKALETVRLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHSGNLH GLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHSGLTPEVVAIASNHGGKALETVRL EVVAIASNHGGKALETVHRDLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHGLTP KALETVRLLPVLCAHGLTPEVVAI SHDGG VLCAHGLTPEVVAI ASNHGGKALETVRLLP VVAIASHDGGKALETAVSNRHLGLGPKVLACLEATHVGLRTLPLEPVVLVCAAHGLTPE ALETVRLLPVLCAHGLTPEVV IASHDGGK CAHGLTPEV AIASHDGGKALETVRLLPVL AIASNHGGKAVLAEITAVSHRDLGLGPKVLACLEATHVGLRTLPLEPVLCAHGLTPEVV ETVRLLPVLCAHGLTP VVAIASHDGGKAL AHGLTP EVVAIASHDGGKALETVRLLPVLC LACLGGERPVAVLADIAAVSKNKGGGLGPRHPAAPLESIVALSRPDPALAALTNDHLVA SE IDNO:728 ALIKRTNRRIPERTSHRVA TALE_HTT_PROM_16 PLASAVHDPLARATLLGGTYVSAVEKIKPKVRSTVAHHEALVGHGFTHAHIVA CTGGGACGCAAGGCGCCGT LTVAGELRGPPLKLYDTDGMILALALPEATHEAIVGVGKWSGARALEALSE IDNO:707 NLTPEVVAIASHDGGKALKEITAVKRRGLGLVPTVALVCEAAVHHGALWTRNALTGAPL NGGGKALETVRLLPVLCAHGL PEVVAIAS RLLPVLCAHGL TPEVVAIASNHGGKALETV TPEVVAIASNHTGPGEKVAVLAEITAVSNRHLGLGPKVLACLEATHVGRLLPVLCAHGL GGKALETVRLLPVLCAH LTPEVVAIASNI LPVLCAH GLTPEVVAIASHDGGKALETVRL EVVAIASGHLDTGPGEKVAVLAEITAVSNRHLGLGPKVLACLEATVRLLPVLCAHGLTP KALETVRLLPVLC HGLTPEVVAIASNIGG VL AHGLTPEVVAIASNIGGKALETVRLLP VVCAIAAHSGNLHTGPGEKVAVLAEITAVSNRHLGLGPKVALETVRLLPVLCAHGLTPE ALETVRLLPVLCAHGLTPEVLVCAIAAHSGNLHTGPGEKVAVLAEITAVSHRDLGLGPK CAHGLTPEVVAIASHDGGKALETVRLL VL AIASHDGGKALETVRLL PVLCAHGLTPEVV ETVRLLPVLCAHGLTPEPVVLVCAIAAHSGNLGTGPGERPVAVLAEISAISVNHGGKAL ALAALTNDHLVALACLGGRPAL ALSRPDP TSHRVA DAVKKGLPHAPALIKRTNRRIPER TALE_HTT_PROM_17 PLAS SAEVHDPLI ARD ATLLN GGO TYVS:729 AVKYEDKMIIKAPAKLVPRESATTVHAEAHIHVEGAVLGVGHGFTHAHIVA GGGGGCTGCCGGGACGGGT LTVAGELRGPPLLDTGLLKIAKRGGVTAVEAVKHAWWSRGNARALEALSE IDNO:708 NLTPEVVAIASNHGGKALETVR ALTGAPL NHGGKALETVR LLPVLCAHGLTPEVVAIAS RLLPVLCAHGLTLPLEPVVLVCAIAAHSGNLHTGPGEKVAVLAEITAVSNHGGKALETV TPEVVAIASNHGGKALET RLLPVLCAHGL GGKALET VRLLPVLCAHGLTPEVVAIASHD LPVLCAHVGLRTLPLEPVVLVCAIAAHSGNLHTGPGEKVAVLAEIASNGGGKALETVRL EVVAIASHDGGKAL TVRLLPVLCAHGLTP KAL ETVRLLPVLCAHGLTPEVVAIASHDGG VLCEATHVGLRTLPLEPVVLVCAIAAHSGNLHTGPGEKVAVAIASNHGGKALETVRLLP VVAIASNHGGKALETVRLLPVLCLEATHVGLRTLPLEPVVLVCAIAAHSGNLITGPGEK ACLEATHVGLRTLPLEPVVLVCAIAAHSGNLTPEVVAIASHDGGKALETVRLLPVL AIASNHGGKALETVRHLGLGPKVLACLEATHVGLRTLPLEPVVLVCAAHGLTPEVV ETVRLLPVLCAHGLTPEV IASNHGGKAL ALAA VAIASNGGGRPALESIVALSRPDP TSLTNDHLVALACLGGRPALDAVKKGLPHAPALIKRTNRRIPER TALE_HTT_PROM_18 PSHERVAIDNO:73 LASAVHDPLARATLLGGTYVS0 AVKYEDKMIIKAPAKLVPRESATTVHAEAHIHVEGAVLGVKGHWGSFGTHAHIVA GCCGGGACGGGTCCAAGAT LTVAGELRGPPLLDTGLLKIAKRGGVTAVEAVHAWRNAARLALEALSE IDNO:709 NLTPEVVAIASNHGGKALETVRL TGAPL HDGGKALETVR LPVLCAHGLTPEVVAIAS RLLPVLCAHGLTLPLEPVVLVCAIAAHSGNLHTGPGEKVAVLAIASHDGGKALETV TPEVVAIASNHGGK ETVRLLPVLCAHGL G ALETVRLLPVLCAHGLTPEVVAIASNH LGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHGLTPEVVAIASNIGGKALETVRL EVVAIASNHGGKALETVSHRDLGLGPKVLACLEATHVGLRTLPLEPVVLVCAHGLTP KALETVRLLPVLCAHGLTPE AIASNHGG VLCAHGLT VVAIASNHGGKALETVRLLP VVAIASHDGPGEKVAVLAEITAVSNRGLGLGPKVLACLEATHVRLLPVLCAHGLTPE ACLEATHVGLRTLPLEPVVLVCAIAAHSGNLITGPGEKVAVLAEITAVSGNL RIT LGP LGEKVAVLAEITAVSHRDLGLGPKVL AIASNHGGKALETVRL PVLCAHGLTPEVV ETVRLLPVLCAHGLTPLEPVVLVCAIAAHSGNLGTGPGERPVAVLAIASNIGGKAL ALAALTNDHLVALACLGGRPALDAVKKGLPHAPAELSIIKVRATNLRSRRIPPDEP TSHRVA R TALE_HTT_PROM_19 PLAS SAEVHDPLI ARD ATLLN GGO TYVS:731 AVKYEDKMIIKAPAKLVPRSTVAHHEALVGHGFTHAHIVA CCAAGATGGACGGCCGCT LTVAGELRGPPLLDTGLLKIAEKARTGHEAIVGVGKWSGARALEALSE IDNO:710 NLTPEVVAIASHDGGKALETVRLGLVPTVALVCEAAVHHGALWTRPNEALVTVGAPL HDGGKALETVRLLPVLCAHGLTPE AIAS RLLPVLCAHGLT VVAIASNIGGKALETV TPEVVAIASNHGPGEKVAVLAEITAVSNRILGLGPKVLACLEATHVRLLPVLCAHGL GGKALETVRLLPVLC GLTPEVVAIASNI LPV AHGLTPEVVAIASNGGGKALETVRL EVLVCAIAAHSGNLHTGPGEKVAVLAEITAVSNRHLGGKALETVRLLPVLCAHGLTP KALETVRLLPVLCAHGLTPLEPVVLVCAIAAHSGHLDTGPGEKVAVLAEIASNIGG VLCAHGLTPEVVAIASNHGGKA TVRLLP VVAIASNHGGK LETVRLLPVLCAHGLTPE ALETVRLLPVLACLEATHVGLRTLPLEPVVLVCAIAAHSGHLTPEVVAIASHDGGK CAHGLTPEVVAIA DGGKALETVRLLPVL AI SNHGGKALETVRLLPVLCAHGLTPEVV ESAISVHADGLGSKRPADLPEATLVAARLLLPVLCAHGLTPEVVAIASNGGGRPAL LIKRTNRRIPERT TNDHLVALACLGGRPALDAVKKGLPHAPA SE IDNO:S7H3R2VA TALE_HTT_PROM_20 PLASAVHDPLARATLLGGTYVSAVKYEDKMIIKAPAKLVPRESATTVHAEAHIHVEGAVLGVKGHWGSFGTAHRAAHLIEVAAL GGACGGCCGCTCAGGTTCT LTVAGELRGPPLLDTGLLKI SE IDNO:711 NLTPEV AKRGGVTAVEAVHAWRNALTGAPL NHGGKAVLAEITAVSNRHLGLGPKVLACLEATHVGLRTLPLEPVVLCAHGLTPEVVAIAS RLLPVLCAHGLTPE VAIASNIGGKALETV TPE VVAIASHDGGKALETVRLLPVLCAHGL GGKVAVLAEITAVSNRHLGLGPKVLACLEATHVGLRTLPLEPVLCAHGLTPEVVAIASNH LPVLCAHGLTPE VVAIASHDGGKALETVRL E VVAIASHDGGKALETVRLLPVLCAHGLTP KVAVLAEITAVSNRHLGLGPKVLACLEATHVGLRTLPLEPVLCAHGLTPEVVAIASHDGG VLCAHGLTPEVVAIASHDGGKVAVLAEITAVSNRGLGLGPKVLACLEATHVGLRTLPLP VVAIASNIGGKALETVRLLPVLCAHGLTP E ALETVRLLPVLCAHGLTP EVVAIASNHGGK CAHGLTPEVVAIASNGGGEKVAVLAEITAVSNRHLGLGPKVLACLEATHVGLRTLPLPVL AIASNGGGKALETVRLLPVLCAHGLTP EVV ETVRLLPVLCAHGLTP EVVAIASHDGGKAL ALAALTNDHLVALACLGGERPVAVLADIAAVSKNKGGGLGPRHPAAPLAESIVALSRPDP TSH LIKRTNRRIPER TALE_HTT_PROM_21 PLAS SAERVA VHDPLI ARD ATLLN GGO TYVS:733 AVKYEDKMIIKPKVRSTVAHHEALVGHGFTHAHIVA CAGGTTCTGCTTTTACCT LTVAGELRGPPLLDTGLALAKLIPAEKARTGHEAIVGVGKWSGARALEALSE IDNO:712 NLTPEVVAIASHDGGKALETVRLGLVPTVALVCEAAVHHGALWTRPNEALVTVGAAIPL NIGGKALETVRLLPVLCAHGLTPEVVAI AS RLLPVLCAHGLTPEVVAI ASNHGGKALETV TPEVVAIASNGGGKALETAVSNRHLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAHGL GGKALETVRLLPVLCAHGLTPEVVAI ASNG LPVLCAHGLTPEVVAI ASHDGGKALETVRL EVVAIASNHGGKALETAVSNRGLGLGPKVLACLEATHVGLRTLPLEPVVLVCAAHGLTP KALETVRLLPVLCAHGLTPEVVA IASHDGG VLCAHGLTPEVVA IASNGGGKALETVRLLP VVAIASNGGGKALEITAVSNRGLGLGPKVLACLEATHVGLRTLPLEPVVLVCAAHGLTPE ALETVRLLPVLCAHGLTPEVVA IASNGGGK CAHGLTPEVVA IASNIGGKALETVRLLPVL AIASHDGGKALEITAVSHRDLGLGPKVLACLEATHVGLRTLPLEPVVLVCAHGLTPEVV ESIVRATNLRSRRIPPDEPRATLSAHARLVTAN AIASNGGGRPAL LIK DHLVALACLGGRPALDAVKKGLPHAPA TALE_HTT_PROM_22 PLAS SAEVHDPLI ARD ATLLN GGO TYVS:734 AVKYEDKMIIKAPAKLVRSTVAHHEALVGHGFTHAHIVA GCGGCCCAGAGCCCCATT LTVAGELRGPPLLDTGLLKIPAEKARTGHGEVATIVGVGKWSGARALEALSE IDNO:713 NLTPEVVAIASNH AVEAVHAWRNALTGAPL HD GGKALETVRLLPVLCAHGLTPEVVAIAS RLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHSGNLHTPEVVAIASNHGGKALETV TPEVVAIASHDGGKALETVRLGLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHSGHLD GLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHSGNLITGPEVVAIASHDGGKALETVRL EKVVAIASNHGGKALETVRLLGPKVLACLEATHVGLRTLPLEPVVLVCAIAAHSGNLITGPG VLACLEATHVGLRTLPLEPVVLVCAIAAHSGHLDTGPGEKVVAIASNHGGKALETVRLLP VVAIASHDGGKA ALETVRLLPVLCAHGLTPE AL LETVRLLPVLCAHGLTPEVVAIASHDGGK CEATHVGLRTLPLEPVVLVCAIAAHSGNLITGPGEKVAVLAEIASHDGGKALETVRLLPVL AIASNGGGKALET TVRLLPVLCAHGLTPEVV ES VRLLPVLCAHGLTPEVVAIASNGGGRPAL LIIKVRATNLRSRRIPPDEPRATLSAHARLVTANDHLVALACLGGRPALDAVKKGLPHAPA SE IDNO:735 - , . .., , . -. .., . , ,-,,,,,, -- - . , ,,,,, -, - -, ,, - - . , ,,,,,,, . HTT_EXP_1 MNAFPSKKSKSRDKLVSGRIHHIGRVTPHATAGMEAKEPRFPAFCDCRICMR GCAGCAGCAGCAGCAGCA AWSTRKRHTKIHTGSKPFCRIICCMGRRNKF SE IDNO:94 SSDLSRHIRTHTGEKPFA FS STRKRHTKIH CDICGRKFAW DLSRHIRTHTTGGESKPKFPAFCDCIRCIGCRMRNFSSS KRHTKIHLRKDAA KFAWSTR SE IDNO:RGSGMDAKSLTAW HTT_EXP_2 MNAFPSKKSKSRDKLVSGRIHH6 IG6 RVTPHATAGMEAKEPRFPAFCDCIRCICMR GCAGCAGCAGCAGCA AWSTRKRHTKIHTGSKPFCRICMGRRNKFF SE IDNO:95 SSDLSRHIRTHTGEKPFAC S STRKRHTKIHT DICGRKFAW LTRHTKIHLRGKEDKAPAFRGCSRGIMCDMARKKSFASGD _3 MS NAE FPSKKI SKD SRDKN LVO LTAW HTT_EXP SG: RIHH6 IG7 RVTPAAMAERPFCRICMR GCAGCAGCAGCAGCA AWSTRKRHTKIHTHGTSGEKPFACDICGRKF SE IDNO:95 SGDLTRHT KPFCRICMRKFA S KIHTGEKPFCRICMRNFSS RDKLRSHRTHKIIRHTLHRTGKEDKPFACDICGRKFAWST SE ID AARGSGMDAKSLTAW HTT_EXP_4 MAPKKK NO:68 KF RKVGIHGVPAAMAERPFCRICMR GCAGCAGCAGCAGCA SASSSDGLDLTRHTKIHTGEKPFCRICMRNF SE IDNO:95 WSTRKRSHRTHKIIRHTTHGTSGEKKPPFFACDICGRKFA SRDKLSRHIRTHTGEKPFACDCIRCIGCRMKRFNAFSWSST EXP_5 MSREHTKIIHLRKDAARGSGMDAKSLTAW HTT_ D NO:69 NAFPSKRKSKDRNKLVSGEIHHIGRVTPHATAGMEAKEPRFPAFCDCIRCIGCMR GCAGCAGCAGCAgCAGCAG AKRCNLRCHTKIHTHPRAPIPKPFCRRIKF SE IDNO:96 RNFSSSDLSRHIRTHTGE CM FAWSTRKRH KPFACDICGRK SSSDLSRHITRKTIHHTTGGESKPKFPAFCDCIRICMRNF WSTRKRHTKIHLRK CGRKFA WSE ID DAARGSGMDAKSLTA HTT_EXP_6 MNAFPSKRKSKDRNKLVSGN EIO HH: IGRV7 TP0 HATAGMAERPFCRICMR GCAGCAgCAGCAGCAGCAG AKRCNLRCHTKIHTGSEKKPPFACDICGRKF SE IDNO:96 RSDNLSEHIRTHTGEKPFAFCDCIRCIGCRMKRFNAFKSR CSNLSRSCDHLTSKRIHHITHPRAPIPKPFCRICMRNF WSTRKRHTKIRHTLHRTGKEDKAPAFRAGCDICGRKFA WSE IDNO: 7 SGMDAKSLTA HTT_EXP_7 MAPKKKRKV 1 NFS GIHGVPAAMAERPFCRICMR GCAGCAGCAgCAGCAG AKRSDNLSEHIRTHTGEKPFACDICGRKF SE IDNO:97 RNRFCSNLSRSCDHLTSKRIHHTHPRAPIPKPFCRICM FAWSTRKRHTKIIRHTTHGTEGKEPKFPFCACDICGRK SGDLTRHTKIH RICMRKFA AWS LRKDAARGSGMDAKSLT HTT_EXP_8 MNAFPSKRKE SKDRNKI LVD SGEIN HHO IG: RVTP7A2AMAERPFCRICMR GCAGCAGCAgCAGCAG AKRCNLRCHTKIHHTGEKPFACDICGRKF SE IDNO:97 RKFASGDLTRHTTKHIPHRTAGPEIKPPKFPFCRCRICM FSSSDLSRHIRTHT ICMRN WSTR GEKPFACDICGRKFA EXP_9 AMWSKERHTIKIHLRKDAARGSGMDAKSLT HTT_ DNO: 73 NAFPSKKSKSRDKLVSGRIHHIGRVTPHATAGMEAKEPRFPAFCCRICMR GCAGCAgCAGCAGcaGCAGCA AWSTRKRHTKIHTPNPHRRTDPDICGRKF SE IDNO:98 RICMRNFSRSDNL SHKPFC CG SEHIRTHTGEKPFACDI MRRNKFFSAKSRSCDNLLSRRCHHTKIHTGSKPFCRIC KFAWSTRKRHTKIIRHTLHRTGKEDKAPAFRAGCDICGR SLTAWSE NFSSGDLVTGRII HHD IGRVN TPO HA: TAGM7 SGMDAK HTT_EXP_10MAPKKKRK EA4 KEPRFPAFCDCIRCIGCRMKRF GCSAEGCAIgDCANGCAGcaGCAGCA ASGDLTRHTKIHTGS O:98 RSDNLSEH KPFCRICMRNFS CNLRCHTKIIRHTTHHTPGREAKPPFACDICGRKFAKR SSGDLTRHIRTHTGEIKPPKFPAFCDCIRCIGCRMRNF SGDLTRHTKIHLRKDA KFA WSE IDN ARGSGMDAKSLTA HTT_EXP_11MNAFPSKRKSKDRNKLVSGEIO HH: IGRV7 TP5 HATAGMEAKEPRFPFCRICMR GCAGCAgCAGCAG ARLWNRKHTKIHTHPRAPIPAKCDICGRKF SE IDNO:99 RNFSSSDLSRHI PFCRICM FA RTHTGEKPFACDICGRK LTAWWSTRSKERHTIKDIHNLOR:K7D6AARGSGMDAKS HTT_EXP_12MNAFPSKRKSKDRNKLVSGEIHHIGRVTPHATAGMEAKEPRFPAFCDCIRCIGCRMKRF GCSAGCAgCAGCAG AKRCNLRCHTKI E IDNO:99 RNFS HTHPRAPIPKPFCRICM FASGSDGLDTLRTHRTHKIIRHTLHRTGKEDKPFACDICGRK LTAWSE ID N AARGSGMDAKS HTT_EXP_13MAPKKKR O:77 NF KVGIHGVPAAMAERPFCRICMR CAGCAGCAGCAGCAGCAG AKSRRSDNLSEHIRTHTGEKPFACDICGRKF SE IDNO:100 RSDCNNLLSRECHHITRKTIHHTTGGESKPKPFCRICMRNFS CNNLRCHTKIHTGSKPFFACCRDIICCMGRRNKFFSARKSRD RLCSHETHKIIRHTLHRTGKEDKAPFACDICGRKFAKRCNL SE IDNOARGSGMDAKSLTAW HTT_EXP_14MAPKKKRK: 78 N VGIHGVPAAMAERPFCRICMR CAGCAGcaGCAGCAGCAGCA AFSWSSSDLSRHIRTHTGEKPFACDICGRKF SE IDNO:101 SSDTLRSKRRHHITRKTIHHTTGGESKPKFPAFCRICMRNFS STRKRHTKIH CDICGRKFAW MR TPNPHRRTDPSHKPFCRIC KFNAFKSRRCSNDLNRLCSHETHKIIRTHTGEKPFACDICGR SLT NFPA SKW HLRKDAARGSGMDAK HTT_EXP_15MAKSKSRS DKE LVSGRII HHD IGRVN TPO HA: TAGM7 EA9 KEPRFPAFCDCIRCIGCRMKRF CASGECAGICDAGNCOA:GcaGCAGCA AWSTRKRHTKIHTPNPHR 101 RICMRNFSRSD RTDPSHKPFC CGRKFAKRCNLNRLCSHETHKIIRHTTHGTSGEKKPFACDI MRNFSRSDNLSEHIR PFCRIC KFAKRC THTGEKPFACDICGR EXP_16 SML NAT FPA SKWNL RKSKDRSR NKECHTKIHLRKDAARGSGMDAK HTT_ LVSGEII HHD IGRVN TPO HA: TAGM8 EA0 KEPRFPAFCDCIRCIGCMR CAGCAGcaGCAGCAgCAGCAG AKRCNLRC RKF SE IDNO:102 S HTKIHTGSKPFCRICMRNFS STSRDKLRSHRTHKIIRHTTHGTSGEKKPFACDICGRKFAW NLSEHIRTHTGEKPFPAFCDCIRCIGCRMKRFNAFKSRRCSD RCHTKIHLRKDAARGSGM NL EXP_17 MS NAE DAKSLTAW HTT_ FPSKRKI SKD DRNKN LVO SG: EIHH8 IG1 RVTPHATAGMEAKEPRFPAFCDCIRCIGCMR CAGCAGcaGCAGCAgCAGCAG AKRCNLRCHTKIHTHPRAPIPKPFCRRIKCFM SE IDNO:102 RFNAFSSGSDGLDTLRTHRHIRTHTGEKPFACDICGRK CRICMRNFSRTSKDINHLTSPENHPIHRRTRTDPSHKPF ICGRKFAKRCNLRCHTKIHLHRTGKEDKAPAFRAGCSD MDAKSLTAWSE IDNO: 82 G HTT_EXP_18MNAPKKKRKVGIHGVPAAMAERPFCRICMR GCTGCTGCTGCTGCTGCT AFHSSSDLSRHIRTHTGEKPFACDICGRKF SE IDNO:103 SRSSDTLRSNRRHHITRKTIHHTTGSKPFCRICMRNFS STRNRHTKIHTGSGEKKPPFFACCRDIICCMGRRKFAHR DLSRHIRTHTGEKP NFSSS NRH FACDICGRKFAHRSTR _19 MSETKIIHDLRNOKDAARGSGMDAKSLTAW HTT_EXP : 83 NAFPSKRKSKDRTKLVSGEIHHIGRVTPHATAGMEAKEPRFPAFCDCIRCICMR GCTGCTGCTGCTgCTGCTG ARRWTLVGHTKIHTHPRAPIPKPFGRKF SE IDNO:104 RNFSSSDLSRHIRT CRICM FAHRS HTGEKPFACDICGRK SSSDTLRSNRRHHITRKTIHHTTGGESKKPFCRICMRNF RSTRNRHTKIHLRKDAPAFRAGCSDGIMCDGARKKSFAH P_20 WMAPSKEKKRIKDVGN LTA HTT_EX IOH:GV8P4 NFSSSDLSRH AAMAERPFCRICMR GCTGCTGCTGCTGCT AHRSTRNRHIRTHTGEKPFACDICGRKF SE IDNO:105 SSDLSRHITRKTIHHTTGGESKPKFPAFCDCRICMRNFS STSRNRHTKIH ICGRKFAHR L TGEKPFCRICMRKFASSD EXP_21 MSREHTKIIHLRKDAARGSGMDAKSLTAW HTT_ D NO:85 NAFPSKKSKSRDKLVSGRIHHIGRVTPHATAGMEAKEPRFPAFCDCIRCIGCRMKR GCTGCTGCTGCTGCT AHRSTRNRHTKIHTGSKPFCRICMRKFF SE IDNO:105 SSDLSRHTKIHTGEKPFC A SDLSRHIRTHT RICMRNFSS RNRHTKIHLRGKEDKAPAFRAGCSDGIMCDGRKFAHRST _EXP_22MSAE AKSLTAW HTT PKKIKDRKNVOG:IH8G6 KFASSDL VPAAMAERPFCRICMR GCTGCTGCTGCTGCT SSSDLSRSHRHTKIHTGEKPFCRICMRNF SE IDNO:105 RSTRNRHTKIIRHTTHGTSGEKKPPFFACCDICGRKFAH SDLSRHIRTHTGEKPFACDIRCIGCRMKRFNAFHSRSST RNSREHTKIIDHLNRO:KD8A7ARGSGMDAKSLTAW HTT_EXP_23MNAFPSKRKSKDRTKLVSGEIHHIGRVTPHATAGMEAKEPRFPFCRICMR GCTGCTgCTGCTGCTGCTG ARRWTLVGHTKIHTGSKPFACCDICGRKF SE IDNO:104 RWSDTLSEHIRTHTGEKPFACDIRCIGCRMKRFNAFRSR STLSVSGDHLTSKRIHHITRHPRAPIPKPFCRICMRNF RSTRNRHTKIHTLHRTGKEDKAPAFRAGCSDICGRKFAH WSE IDNO: 88 GMDAKSLTA HTT_EXP_24MNAFPSKKKRKVGIHGVPAAMAERPFCRICMR GCTGCTGCTgCTGCTG ARRSDTLSEHIRTHTGEKPFACDICGRKF SE IDNO:106 RNRFWSTLSVSGDHLTSKRIHHTHPRAPIPKPFCRICM FAHRSTRNRHTKIIRHTTHGTEGKEPKFPFCACDICGRK SSDLSRHTKIH RICMRKFA AW LRKDAARGSGMDAKSLT HTT_EXP_25MNAFPSKS RKE SKDRTKI LVD SGEIN HHO IG: RVTP8A9AMAERPFCRICMR GCTGCTGCTgCTGCTG ARRWTLVGHTKIHHTGEKPFACDICGRKF SE IDNO:106 RKFASSDLSRHTTKHIPHRTAGPEIKPPKFPFCCRICM FSSSDLSRHIRTH RICMRN HRST TGEKPFACDICGRKFA T_EXP_26AMWR NAFPSKSNRHTKIHLRKDAARGSGMDAKSLT HT RKE SKDRTKI LVD SGEIN HHO IG: RVTP9 HA0 TAGMEAKEPRFPAFCRICMR CTGCTGCTGCTGCTGCTG ARRWTLVGHTKIHTGSKPFCCRDICGRKF SE IDNO:107 RSDTLSEHIRTH ICMRNFS WT TGEKPFACDICGRKFARR TLLSVEGHHITRKTIHHTTGGESKKPFCRICMRNFSRSD VGHTKIHLRKDAPAFRAGCSDGIMCDGARKKFARRWTL XP_27 MS NAE FPSKKI SKD SLTAW HTT_E RKNVOG:IH9G1VPAAMAERPFCRICMR CTGCTGctGCTGCTGCTGCT AHRSSDLSRHIRTHTGEKPFACDICGRKF SE IDNO:108 SSDTLRSNRRHHITRKTIHHTTGGESKPFCRICMRNFS STRNRHTKIHTPNPHKRPRFTADCPDSIHCKGPRKFAHR MRNFSRSDTLSEHI FCRIC KFAR RTHTGEKPFACDICGR SLTARWWTLSVEGHTIKDIHNLOR:K9D2AARGSGMDAK HTT_EXP_28 MNAFPSKRKSKDRTKLVSGEIHHIGRVTPHATAGMEAKEPRFPAFCDCIRCIGCRMKRF CTSGECTGIctGCTGCTgCTGCTG ARRWTLVGHTKIHTHP D NO:109 RNFSSSDLSRH RAPIPKPFCRICM FAHRSTRNRHTKIIRHTTHPTNGPEHKRPRFTADCPDSIHCKGPRFK CIRCIGCRMKRFNAFRSRRWSTDLTVLGSHETHKIRTHTGEKPFACD MDAKSLTAWSE IDIHNLOR:K9D3AARGSG - ,.., - - . , -,,,,,, - - , , - . ,,,,,,, - . - ,,,,,-,,, - . - TEAXLPE__1HTT_ AGSCEAGCIADGCNAOG:CA7G3C6 PAAAVDLRTLGYS EKIKPKVRSTVAHHEALVGHGFTHAHIV ALLSLTHVPAAGAELLGRTGVPAPVLKYLDDTMGIALALLKPIEAAKTRHGEGAVITVAGVVEGAKVHWASWGRANRALE APLNLTPEVVAIASNIGGK ALTG AIA ALETVRLLPVLCAHGLTPEVV LETSVNHRGLGLKPVALLETVRLLPVLCAHGLTPEVVAIASHDGGKA CAHGLTPEVCVAAIHAGSLNTHPGEVVAIASNIGGKALETVRLLPVL VAIASHDGGKALETVRLGLKPVALLCETAVHGRLLPVLCAHGLTPEV ALETVRLLPVLCAHGLTPEVVAIASLNTHPGEGKVVAALIASNIGGK LCAHGLTPEVVAIASHDGGKALETVRLLPVLCETAVHGRLLTLPPEV VVAALIEATSVNIRGLGLKPVALETVRLLPVLCAHGLTPEVVAIASNHGGK VLCAHGLTPELVCVAAIHAGSLNTIPGEGKVVAAIASHDGGKALETVRLLP VVAIASNHGGKALETVRLLPVLLCETAVHGRLLTLPPEVLVCVAAHGLTPE RPPHALESIVALSRPDPALAALTNDHLVALACLGGRPALIDAASVHKDKGGGL SAEPALIKRTNRRIPERTSHRVA TALE_2HTT_ AGSCEAGCIADGC ID NO:758 EXP_ NAOG:CA7G3C7A PAAAVDLRTLGYS EKIKPKVRSTVAHHEALVGHGFTHAHIV ALLSLTHVPAAGAELLGRTGVPAPVLKYLDDTMGIALALLKPIEAATHEAIVGVGKWSGARALE APLNLT KRGGVTAVEAVHAWRNALTG AIASNHPGEGKVVAALIEATSVNIRGLGLKALETVRLLPVLCAHGLTPEVV LETVRLLPVLCAHGLTPPEVLVCVAAIHAGSLNTIPGEGVVAIASHDGGKA CVAHGLTPEVVAIASNHGGKALETVRLLKPVALLCETAVHGRLLTLPPEVLV AALIEATSVHDRGLGLKPVALLETVRLLPVLCAHGLTPEVVAIASNIGGK LCAHGLTPEVCVAAIHAGSLHTDPGEGKVVAALIASNHGGKALETVRLLPV VVAIASNIGGKALETVRLLPVLCETAVHGRLLTLPPEVLVCVAAIHGLTPE ALETVRLLPVLCAHGLTP ASNHGGK VLCAH EVVAIASHDGGKALETVRLLP VVAIAGSLNTHPGEGKVVAALIEATSVNIGGKALETVRLLPVLCAHGLTPE KALETVRLLPVLCAHGRLLTLPPEVLVCVAAIHAGSLNTPEVVAIASHDGG SRPDPALAALTNDHLVALACLGGRPALDAVKIKGGGLRPPHAALPESIVAL RRIPE ALIKRTN SERITDSHNROVA TALE_HTT_ AGCAGCIADGCNAOG:CA : 759 EXP_3 SE 7G3C8AGPAAAVDLRTLGYS EKIKPKVRSTVAHHEALVGHGFTHAHIV ALSHPAALGTVAVKYDMIAALPEATHEAIVGVGKWSGARALE ALPLLTNVLATGPEELRVGPPLLDTGLLKIAKRGGVTAVEAVHAWRNALTG AIASNHGGKVAALIEATSVNIRGLGLKPVALLETVRLLPVLCAHGLTPEVV LETVRLLPVLCAHGLTPEVCVAAIHAGSLNTIPGEGKVVAALIASHDGGKA CAHGLTPEVVAIASNH ETVRLLPVL VAI GGKALETVRLLPVLCAHGLTPEV ALEATSVHDRGLGLKPVALLCETAVHRLLPVLCAHGLTPEVVAIASNIGGK LCAHGLTPEVVAIAGSLHTDPGEGKVVAALIEATSVNHGGKALETVRLLPV VVAIASNIGGKALETVRLLPVLCAHGRLLTLPPEVLVCVAAIHAGSLNTPE ALETVRLLPVLCAHGLTPEVV HGGK VLCAHGLT AIASHDGGKALETVRLLP VVAIASNHPGEGKVVAALIEATSVNIRGLGLKALETVRLLPVLCAHGLTPE KALETVRLLPVLCAHGLTPPEVLVCVAAIHAGSLNTIPGEGVVAIASHDGG PVLCAHGLTPEVVAIASNHGGRPALESIVALKSRAPLDEPTAVLARALLLT NADHLVALACLGGRPALDAVKKGLPHAPALIKRTNRRIPERTSHRV TEAXLPE__4HTT_ ACGCAGCAGCAGCAGCAGPS AAE LASVDI HLD PRATN ALO LG: GYTS760 VAVKYEKDIMKIPAKAVLRPSETVAHHEALVGHGFTHAHIV SE IDNO:739 ALLTVAGELRGPPLLDTGLLKIATHEAIVGVGKWSGARALE APLNLTPEVVAIASNIGGKALEATKVRGRGLVLTPAVVEAVHAWRNALTG ALIASNHGGKALETVRLLPVLCAHGLTPELVCVAAIHAGSLHTDPGEGKVVA CETAVHGRLLTLPPEVLVCVAAHGLTPEVVAIASNIGGKALETVRLLPVL VAIASHDGGKALIEATSVNHRGLGLKPVALLCETAVRLLPVLCAHGLTPEV ALETVRLLPVLCAHGLTPEVVAIHAGSLNTHPGEGKVVAALIEASNIGGK LCAHGLTPEVVAIASHDG TVRLLPV VVAIA GKALETVRLLPVLCAHGLTPE ALETSVNIRGLGLKPVALLCETAVHRLLPVLCAHGLTPEVVAIASNHGGK VLCAHGLTPEVVAIAGSLNTIPGEGKVVAALIEATSVHDGGKALETVRLLP VVAIASNHGGKALETVRLLPVLCAHGRLLTLPPEVLVCVAAIHAGSLTPE KALETVRLLPVLCAHGLTPEV HDGG PVLCAHGL VAIASNIGGKALETVRLL EVVAIASHTDPGEGRVPVAALIEASSINVHGGKALETVRLLPVLCAHGLTP GRPALDAVKKGLPHAPALIKARTLNSRRRPIDPPALAALTNDHLVALACLG T_ AGCAGCAGCAGCAGCAGPSAEAVDILD ERTSHRVA TALE_HT NO:761 EXP_5 CA ALSHPRATALLGGYTS EKIKPKVRSTVAHHEALVGHGFTHAHIV SE IDNO:740 ALLTVAGEVAVKYDMIAALPEATHEAIVGVGKWSGARALE APLNLTPELRVGVPAPILASLNDITGLLKIAKRGGVTAVEAVHAWRNALTG AIASNHGGKALETVRGLGLKPVALLCETAVHGRLLTLPVLCAHGLTPEVV LETVRLLPVLCAHGLTPEVVAIASNIPGEGKVVAALIEATSVHDRGLGLKA CAHGLTPEVVAIASNHGGKALE PVL VAIASHDGG TVRLLPVLCAHGLTPEV ALETVRLLKPVALLCETAVHGRLLTLPPEVLVCAHGLTPEVVAIASNIGGK LCAHGLTPEVVAIASHDGGKVAALIEATSVNHRGLGLKPVALETVRLLPV VVAIASNIGGKALETV LCAHGLTPE A RLLPVLCAHGLTPEVVAIASNHGGK VLLCETAVHGRLLTLPPEVLVCVAAHGLTPEVVAIASHDGGKALETVRLLP VVAIASNHGGKALIEATSVNIRGLGLKPVALLCETAVRLLPVLCAHGLTPE KALETVRLLPVLCAHGLTPEVVAIHAGSLNTIPGEGKVVAALIEASHDGG PVLCAHGLTPEVVAIASNHG TVRLL EVVAIA GKALETVRLLPVLCAHGLTP GRPALESSIHVDAGGLKSRAPLDEPTAVRLLPVLCAHGLTPEVVAIASNIG LPHAPALIKRTNRRIPERLTASAHLRTVNADHLVALACLGGRPALDAVKKG TEAXLPE__6HTT_ ACGACGAGCAGCAGCAGCAGPS AAE LASVDI HLD PRATN ALO LG: GYTS762 VAVKYEKDIMKIPKVRSTVAHHEALVGHGFTHAHIV SE IDNO:741 ALLTVAGELRGPPLLDTAALPEATHEAIVGVGKWSGARALE APLNLTPEVVAIASNIGGGKLLAKLIEATKVRGRGLVTAVEAVHAWRNALTG AIASNHGGKALETVRLLPVLCAHGLTLPPEVLVCVAAIHAGSLHTDPGEVV LETVRLLPVLCAHGLTPEVVAIA GKA CAHGLTPEV SNIGGKALETVRLLPVL VAIASHDGGKVAALIEATSVNHRGLGLKPVALLETVRLLPVLCAHGLTPEV ALETVRLLPVLCAHGLTPEVCVAAIHAGSLNTHPGEGKVVAALIEASNIGGK LCAHGLTPEVVAIASHDG TVRLLPV VVAIA GKALETVRLLPVLCAHGLTPE ALETSVNIRGLGLKPVALLCETAVHGRLLPVLCAHGLTPEVVAIASNHGGK VLCAHGLTPEVVAIASLNTIPGEGKVVAALIEATSVHDRGGKALETVRLLP VVAIASNHGGKALETVRLLPVLCAHGLLTLPPEVLVCVAAIHAGSLHTDPGE KALETVRLLPVLCAHGLTPEVVAI G PVLCAHGLTPE ASNIGGKALETVRLL EVVAIASHDGGKVVAALIEATSVNHRGLGLKPVALLETVRLLPVLCAHGLTP GKALETVRLLPVLCAHGLTPEVCVAAIHAGSLNTHPGEGRVPVAAIASNIG LSRRRPIDPPEARLTASAHLRTVNADHLVALA LESIVA N CLGGRPALDAVKKGLPHAPALIKRT TALE_HTT_ GCTGCTGCTGCTGCT PSAEAVDIDNO:763 EXP_7 SE IDNO:742 A LRTLGYS EKIKPKVRSTVAHHEALVGHGFTHAHIV ALLSLTHVPAAGAELLGRTVAVKYDMIAALPEATHEAIVGVGKWSGARALE APLNLTPEVGVPAPILASLNDHTGGGKLLKIAKRGGVTAVEAVHAWRNALTG AIASHDGGKALETVRLLPVALLCETAVHGRLLTLPPEVLVCVAHGLTPEVV LETVRLLPVLCAHGLT AIASNGGGKA CA PEVVAIASNHGGKALETVRLLPVL VAIHAGSLNTGPGEGKVVAALIEATSHDGGKALETVRLLPVLCAHGLTPEV ALETVRLLPVLCAVHGRLLTLPPEVLVCVAAIHAGSLHTPEVVAIASNHGGK LCAHGLTPEVVAIASNGGGKALETVDRGLGLKPVALLCETAVHGRLLTLPV VVAIASNHGGKALETVRLLPVLCA PE ALETVRLLP HGLTPEVVAIASHDGGK VLCAHGLTPEVLVCVAAIHAGSLNTHPGEGKVVAIASNGGGKALETVRLLP VVAIASHDGGKALETVRLLPVALLCETAVHGRLLTLPPEVLVCVAAHGLTPE RPPHALESIVALSRPDPALAALTNDHLVALACLGGRPALIDAASVNKGKGGGL SAEPALIIKRTNRRIPERTSHRVA TALE_HTT_ GCTGCTGCTG D NO:764 EXP_8 SE IDNOC:TG7C4T3G PAALASVDHLPRATALLGGYTSVAVKYEKDIMKIPAKAVLRPSETAVTAHEHAHIEVAGLVVGGKHGWFSTGHAARHAILVE AALPLLTNVLATGPEELRGPPLLDTGLLKIAKRGGVTAVEAVHAWRNALTG AIASHDGGKVVAALIEATSVNHRGLGLKPVALETVRLLPVLCAHGLTPEVV LETVRLLPVLCAHGLTPELVCVAAIHAGSLNTHPGEGKVVAAIASNGGGKA CAHGLTPEVVAIASH LETVRLLPVL VA DGGKALETVRLLPVLCAHGLTPEV ALIEATSVNGRGLGLKPVALLCETAVRLLPVLCAHGLTPEVVAIASNHGGK LCAHGLTPEVVAIHAGSLNTGPGEGKVVAALIEATSHDGGKALETVRLLPV VVAIASNHGGKALETVRLLPVLCAVHGRLLTLPPEVLVCVAAIHAGSLTPE ALETVRLLPVLCAHGLTPEV HDGGK VLCAHGL VAIASNGGGKALETVRLLP VVAIASHTDPGEGKVVAALIEATSVNHRGLGKALETVRLLPVLCAHGLTPE KALETVRLLPVLCAHGLTLPPEVLVCVAAIHAGSLNTHPGEVVAIASNGGG SRPDPALAALTNDHLVALACLGGRPALDAVKKGGLRPPHAALPEASLIVAL RRIPERT IKRTN TALE_HTT_ TGCTGCTGCTGCTGC SE IDSHNROV:A765 EXP_9 SE IDNO:744 PAAAVDLRTLGYS EKIKPKVRSTVAHHEALVGHGFTHAHIV ALLSLTHVPAALGTVAVKYDMIAALPEATHEAIVGVGKWSGARALE APLNLATGPEELRVGVPAPILALDTGLLKIAKRGGVTAVEAVHAWRNALTG AIASNHGGKALETSVNGRGLGLKPVALLCETAVHGRLLPVLCAHGLTPEVV LETVRLLPVLCAHGLTPEVVAIASLNTGPGEGKVVAALIEATSVHDRGGKA CAHGLTPEVVAIASNHGGKA LLPVL VAIASHD LETVRLLPVLCAHGLTPEV ALETVRGLGLKPVALLCETAVHGRLLTLPPVLCAHGLTPEVVAIASNGGGK LCAHGLTPEVVAIASHDGEGKVVAALIEATSVNHRGLGLKPALETVRLLPV VVAIASNGGGKALETVRLLPVLCAHGLTPEVLVCVAAIHAGSLNTHPGEGK VALLCETAVHGRLLTLPPEVLVCVAHGLTPEVVAIASHDGGKALETVRLLP VVAIASNHGGKAALIEATSVNGRGLGLKPVALLCETVRLLPVLCAHGLTPE RPALESIVALSRPDPALAALTNDHLVAAHLGALCTLPGEGRVVAIASHDGG PHAPALIKRTNRRIP PALDAVKKGL EXP_10_ TGSCETGCITDGCNTOG:CT7G4C5T PS AAE LASVDI HLD PRATN ERTSHRVA TALE_HTT ALO LG: GYTS766 VAVKYEKDIMKIPAKAVLRPSETAVTAHEHAHIEALVGHGFTHAHIV ALLTVAGELRGPPLLDTGLLKIAKRGGVTVAGVVEGAKVHWASWGRARALE APLNLTPEVVAIASNGGGKA NALTG AIASNH LETVRLLPVLCAHGLTPEVV LETVRGLGLKPVALLCETAVHGRLLTLPPVLCAHGLTPEVVAIASHDGGKA CAHGLTPEVVAIASNHGEGKVVAALIEATSVNGRGLGLKPALETVRLLPVL VAIASHDGGKALETVRLLPVLCAHGLTPEVLVCVAAIHAGSLNTGPGEGKV ALLCETAVHGRLLTLPPEVLVCAHGLTPEVVAIASNHGGKALETVRLLPV VVAIASNGGGKVAALIEATSVHDRGLGLKPVALLETVRLLPVLCAHGLTPE ALETVRLLPVLCAHGLTPEVCVAAIHAGSLHTDPGEGKVVAALIASNHGGK VLCAHGLTPEVVAIASNG ETVRLLP VVAI GGKALETVRLLPVLCAHGLTPE KALEATSVNHRGLGLKPVALLCETAVHRLLPVLCAHGLTPEVVAIASHDGG SRPDPALAALTNDHLVALGALCTLPGEGRVPVAAIASNGGGRPALESIVAL RRIPER LDAVKKGLPHAPALIKRTN EXP_11 CSTEGCTIGDCTNGOC:TG7C4T6 PS AAE LASVDIT HLDSH PRATNR ALOV LG:A TALE_HTT_ G GYTS767 VAVKYEKDIMKIPAKAVLRPSETAVTAHEHAHIEVAGLVGHGFTHAHIV ALLTVAGELRGPPLLDTGLLKIAKRGGVTAVVEGAKVHWASWGRANRAALE APLNLTPEVVAIASNHGGKALE LTG AIASHDGG TVRLLPVLCAHGLTPEVV LETVRLLKPVALLCETAVHGRLLTLPPEVLVCAHGLTPEVVAIASNGGGKA CAHGLTPEVVAIASHDGGKVAALIEATSVNHRGLGLKPVALLETVRLLPVL VAIASNGGGKALETVR CAHGLTPEV AL LLPVLCAHGLTPEVVAIASNHGGK LCETAVHGRLLTLPPEVLVCVAAIHGLTPEVVAIASHDGGKALETVRLLPV VVAIASNHGGKALEATSVNGRGLGLKPVALLCETAVHRLLPVLCAHGLTPE ALETVRLLPVLCAHGLTPEVVAIAGSLNTGPGEGKVVAALIEATSHDGGK VLCAHGLTPEVVAIASNHGG VRLLP VVAIAS KALETVRLLPVLCAHGLTPE RPALESIHVDAGGLKSRAPLDEPTAVLRLLPVLCAHGLTPEVVAIASNGGG PHAPALIKRTN AALTNDHLVALACLGGRPALDAVKKGL S RRIPERTSHRVA TEAXLPE__1H2TT_ TGSCETGCITDGCNTOG:CT7G4C7 PAAE LASVDI HLD PRATN ALO LG: GYTS768 VAVEKIKPKVRSTVAHHEALVGHGFTHAHIV ALLTVAGELRGPPLKYLDDTMGIALALLKPIEATHEAIVGVGKWSGARALE APLNLTPEVVAIASNGGGKALEATKVRGRGLVLTPAVVLEAVHAWRNALTG AIASNHGGKALETVR CAHGLTPEVV L LLPVLCAHGLTPEVVAIASHDGGKA CETAVHGRLLTLPPEVLVCVAAIHGLTPEVVAIASNGGGKALETVRLLPVL VAIASHDGGKALEATSVNHRGLGLKPVALLCETAVHRLLPVLCAHGLTPEV ALETVRLLPVLCAHGLTPEVVAIAGSLNTHPGEGKVVAALIEATSVNGGGK LCAHGLTPEVVAIASHDGGK RLLPV VVAIASN ALETVRLLPVLCAHGLTPE ALETVGRGLGLKPVALLCETAVHGRLLTLPVLCAHGLTPEVVAIASNHGGK VLCAHGLTPEVVAIASNGPGEGKVVAALIEATSVHDRGLGLKALETVRLLP VVAIASNHGGKALETVRLLPVLCAHGLTPPEVLVCVAAIHAGSLHTDPGEG RPPHAALPEASLIVALSRPDPALAALTNDHLVALACLGGRPALDAVKKGL SE IIDKRNTON:RR7IPERTSHRVA TALE_HTT_ GCTGCTGCTGCTGCT 69 EXP_13 SE IDNO:748G PAAAVDLRTLGYS EKIKPKVRSTVAHHEALVGHGFTHAHIV ALLSHPAALGTVAVKYDMIAALPEATHEAIVGVGKWSGARALE APLLTNVLATGPEELRVGPPLLDTGLLKIAKRGGVTAVEAVHAWRNALTG AIASHDGGKVAALIEATSVNHRGLGLKPVALLETVRLLPVLCAHGLTPEVV LETVRLLPVLCAHGLTPEVCVAAIHAGSLNTHPGEGKVVAALIASNGGGKA CAHGLTPEVVAIASHD ETVRLLPVL VAI GGKALETVRLLPVLCAHGLTPEV ALEATSVNGRGLGLKPVALLCETAVRLLPVLCAHGLTPEVVAIASNHGGK LCAHGLTPEVVAIHAGSLNTGPGEGKVVAALIEATSHDGGKALETVRLLPV VVAIASNHGGKALETVRLLPVLCAVHGRLLTLPPEVLVCVAAIHAGSLTPE ALETVRLLPVLCAHGLTPEV HDGGK VLCAHGL VAIASNGGGKALETVRLLP VVAIASHTDPGEGKVVAALIEATSVNHRGGKALETVRLLPVLCAHGLTPE KALETVRLLPVLCAHGLLTLPPEVLVCVAAIHAGSLNTHPEVVAIASNGGG SRPDPALAALTNDHLVALACLGGRPALDAVKKGGGLRPPHAALPEASIVAL RRIPER LIKRTN SE ITDSHNROV:A TALE_HTT_ TGCTGCTGCTGCTG 770 EXP_14 SE IDNO:74C9T PAAAVDLRTLGYS EKIKPKVRSTVAHHEALVGHGFTHAHIV ALSHPAALGTVAVKYDMIAALPEATHEAIVGVGKWSGARALE ALPLLTNVLATGPEELRVGPPLLDTGLLKIAKRGGVTAVEAVHAWRNALTG AIASNHGGKVAALIEATSVNGRGLGLKPVALLETVRLLPVLCAHGLTPEVV LETVRLLPVLCAHGLTPEVCVAAIHAGSLNTGPGEGKVVAAIASHDGGKA CAHGLTPEVVAIASN LETVRLLPVL VA HGGKALETVRLLPVLCAHGLTPEV ALIEATSVHDRGLGLKPVALLCETAVRLLPVLCAHGLTPEVVAIASNGGGK LCAHGLTPEVVAIHAGSLHTDPGEGKVVAALIEATSNHGGKALETVRLLPV VVAIASNGGGKALETVRLLPVLCAVHGRLLTLPPEVLVCVAAIHAGLTPE ALETVRLLPVLCAHGLTPE SNHGGK VLCAHG VVAIASHDGGKALETVRLLP VVAIASLNTHPGEGKVVAALIEATSVNGRGGKALETVRLLPVLCAHGLTPE KALETVRLLPVLCAHGLLTLPPEVLVCVAAIHAGSLNTGPEVVAIASHDGG SRPDPALAALTNDHLVALACLGGRPALDAVKKGGGLRPPHAALPESIVAL RRIPE ALIKRTN SERITDSHNROVA TALE_HTT_ TGCTGCTGCTGCT : 771 EXP_15 SE IDNO:7G5C0TGPAALASVDHLPRATALLGGYTSVAVKYEKDIMKIPAKAVLRPSETAVTAHEHAHIEVAGLVVGGKHGWFSTGHAARHAILVE AALPLLTNVLATGPELRGPPLLDTGLLKIAKRGGVTAVEAVHAWRNALTG AIASNHGEGKVVAALIEATSVNGRGLGLKALETVRLLPVLCAHGLTPEVV LETVRLLPVLCAHGLTPPEVLVCVAAIHAGSLNTGPGEVVAIASHDGGKA CAHGLTPEVVAIASNHGGKALETVRLGLKPVALLCETAVHGRLLTLPPEVL VAIASHDGGKALETVRLLPVLCAH V ALETVRLLP GLTPEVVAIASNGGGK LCAHGLTPEVLVCVAAIHAGSLHTDPGEGVVAIASNHGGKALETVRLLPV VVAIASNGGGKALETVRLLKPVALLCETAVHGRLLTLPPEVLCAHGLTPE ALLETVRLLPVLCAH VVAIASNHGGK V GLTPEVVAIASHDGGKALETVRLLP VCVAAIHAGSLNTHPGEGKVVAIASNGGGKALETVRLLPVLCAHGLTPE KALETVRLLPVALLCETAVHGRLLTLPPEVLVCAHGLTPEVVAIASHDGG PVLCAHGLTPEVVAIASNHGGRPVAALIEASSINVGAGGLKSALETVRLL NDHLVALACLGGRPALDAVKKGLPHAPALIKRTNRRRPIDPPEARLTAALT A SHRV TALE_HTT_ GCTGCTGCTGCTGCTGCPSAEAVDILDRTNLO:772 EXP_16 SE IDNO:751 ALS GYS EKIKPKVRSTVAHHEALVGHGFTHAHIV ALLTHVPAAGAELLGRTGVAVKYDMIAALPEATHEAIVGVGKWSGARALE APLNLTPEVVPAPILASLNDHTGGGKLLKIAKRGGVTAVEAVHAWRNALTG AIASHDGGKALETVRLLPVALLCETAVHGRLLTLPPEVLVCAHGLTPEVV LETVRLLPVLCAHGLTPEVVAIASNHGGKVAALIEATSVNGRGLGLKPVA CAHGLTPEVVAIASHDGGKALETV L VAIASNGGGK RLLPVLCAHGLTPEV ALETVRLLPVALLCETAVHGRLLTLPPEVLVCVAHGLTPEVVAIASNHGGK LCAHGLTPEVVAIASNGGGKAALIEATSVHDRGLGLKPVALLETVRLLPV VVAIASNHGGKALETVR CAHGLTPE A LLPVLCAHGLTPEVVAIASHDGGK VLLCETAVHGRLLTLPPEVLVCVAHGLTPEVVAIASNGGGKALETVRLLP VVAIASHDGGKAALIEATSVNHRGLGLKPVALLCETVRLLPVLCAHGLTPE KALETVRLLPVLCAHGLTPEVVAAIHAGSLNTHPGEGKVVAALIASNGGG PVLCAHGLTPEVVAIASHD ETVRLL ND GGRPALESIVALSRPDPALAALT AHLVALACLGGRPALDAVKKGLPHAPALIKRTNRRIPERTSHRV TEAXLPE__1H7TT_ GTCTGCTGCTGCTGCTGCPS AAE LASVDI HLD PRATN ALO LG: GYTS773 VAVKYEKDIMKIPAKAVLRPSETAVAHHEALVGHGFTHAHIV SE IDNO:752 ALLTVAGELRGPPLLDTGLLKITHEAIVGVGKWSGARALE APLNLTPEVVAIASNHGGKALEATKVRGRGLVLTPAVVEAVHAWRNALTG AIASHDGGKALETVRLLPVLCAHGLTPELVCVAAIHAGSLNTGPGEGKVVA LCETAVHGRLLTLPPEVLVCVAAIHGLTPEVVAIASNHGGKALETVRLLPVL VAIASNGGGKALEATSVHDRGLGLKPVALLCETAVHGRLLPVLCAHGLTPEV ALETVRLLPVLCAHGLTPEVVAIASLHTDPGEGKVVAALIEATSVNHRGLGK LCAHGLTPEVVAIASNGGGKALE LPV VVAIASNHGG TVRLLPVLCAHGLTPE ALETVRLLKPVALLCETAVHGRLLTLPPEVLVCVAHGLTPEVVAIASHDGGK VLCAHGLTPEVVAIASNHGGKAALIEATSVNGRGLGLKPVALLCETAVRLLP VVAIASHDGGKALETVRLLP HGLTPE KALETV VLCAHGLTPEVVAIASNGGG PVLCAHGRLLTLPPEVLVCVAAIHAGSLHTDPEVVAIASNHGGKALETVRLL EVVAIASNGGGRPALESIVAGGLKSRAPLDEPTAVLARALLLPVLCAHGLTP GRPALDAVKKGLPH TNDHLVALACLG SE IDN APALIKRTNRRIPERTSHRVA TEAXLPE__1H8TT_ TCGCTGCTGCTGCTGCTGPAALASVDHLPRATALO LG: GYTS774 VAVKYEKDIMKIPAKAVLRPSETAVTAHHHEALVGHGFTHAHIV SE IDNO:753 ALLTVAGELRGPPLLDTGLLKIAKRGEAIVGVGKWSGARALE APLNLTPEVVAIASNGGGKALETVRGLVLTPAVVLECAVAHHAGWLRNALTG AIASNHGGKALETVRLLPVLC TPEVV LETVRLL AHGLTPEVVAIASHDGGKA CAHGLTPPEVLVCVAAIHAGSLNTHPGEGKVVAAIASNGGGKALETVRLLPVL VAIASHDGGKALETVRLLPVLLCETAVHGRLLTLPPEVLVCVAAIHGLTPEV ALETVRLLPVLCAHGLTPE ASNGGGK LCAHG VVAIASNHGGKALETVRLLPV VVAIASLNTGPGEGKVVAALIEATSVHDRGLGKALETVRLLPVLCAHGLTPE ALETVRLLPVLCAHGLTLPPEVLVCVAAIHAGSLHTDPGEGVVAIASNHGGK VLCAHGLTPEVVAIAS KALETVRLLP VV NGGGKALETVRLLPVLCAHGLTPE KAALIEATSVNHRGLGLKPVALLCETAVRLLPVLCAHGLTPEVVAIASHDGG PVLCAHGLTPEVVAIHAGSLNTHPGEGKVVAALIEATSVNGGGKALETVRLL EVVAIASHDGGRPALESIVALSRPDPALARALLLTPNVDLHCLVAAHLGLTP GRPALDAVKKGLPHAPALIKRTNRRIPERTSHRVA ACLG TEAXLPE__1H9TT_ GTCGTGCTGCTGCTGCTGCPS AAE LASVDI HLD PRATN ALO LG: GYTS775 VAVKYEKDIMKIPAKAVLRPSETAVTAHEHAHIEVAGLVVGGHGFTHAHIV SE IDNO:754 ALLTVAGELRGPPLLDTGLLKIAKRGGVTAVEAKWSGARALE APLNLTPEVVAIASNH VHAWRNALTG AI GGKALETVRLLPVLCAHGLTPEVV LEATSVHDRGLGLKPVALLCETAVHGRLLPVLCAHGLTPEVVAIASNGGGKA CAHGLTPEVVAIASLHTDPGEGKVVAALIEATSVNHRGLGKALETVRLLPVL VAIASNGGGKALETVRLLPVLCAHGLTLPPEVLVCVAAIHAGSLNTHPGEGKV ALLCETAVHGRLLTLPPEVLVCVAHGLTPEVVAIASHDGGKALETVRLLPV VVAIASNHGGKAALIEATSVNGRGLGLKPVALLCETAVRLLPVLCAHGLTPE ALETVRLLPVLCAHGLTPEVVAIHAGSLNTGPGEGKVVAALIEATSHDGGK VLCAHGLTPEVVAIASNHGGK VRLLP VVAIASH ALETVRLLPVLCAHGLTPE KALETVDRGLGLKPVALLCETAVHGRLLTLPVLCAHGLTPEVVAIASNGGG PVLCAHGLTPEVVAIASHDPGEGKVVAALIEATSVNHRGLGLKPALETVRLL EVVAIASNGGGKALET VLCAHGLTP GR VRLLPVLCAHGLTPEVVAIASNHG LPPHAALPEASLIIVKARLSRPDPALAALTNDHLVALACLGGRPALDAVKKG ALE_HTT_ TGCTGCTGCTGCTGCTGPSE IDTNRRIPERTSHRVA T NO:776 EXP_20 CT AALASVDHLPRTLGYS EKIKPKVRSTVAHHEALVGHGFTHAHIV SE IDNO:755 ALLTAALGTVAVKYDMIAALPEATHEAIVGVGKWSGARALE APLNVLATGPEELRVGVPAPILALDTGLLKIAKRGGVTAVEAVHAWRNALTG AIASNHGGKALETSVNGRGLGLKPVALLCETAVHGRLLPVLCAHGLTPEVV LETVRLLPVLCAHGLTPEVVAIASLNTGPGEGKVVAALIEATSVHDRGLGKA CAHGLTPEVVAIASNHGGKAL LPVL VAIASHDG ETVRLLPVLCAHGLTPEV ALETVRLGLKPVALLCETAVHGRLLTLPPEVLVCAHGLTPEVVAIASNGGGK LCAHGLTPEVVAIASHDGGKVAALIEATSVNHRGLGLKPVALLETVRLLPV VVAIASNGGGKALETVRL CAHGLTPE ALE LPVLCAHGLTPEVVAIASNHGGK VLCTAVHGRLLTLPPEVLVCVAAIHAGLTPEVVAIASHDGGKALETVRLLP VVAIASNHGGKALETSVNGRGLGLKPVALLCETAVHGRLLLPVLCAHGLTPE KALETVRLLPVLCAHGLTPEVVAIASNTGPGEGKVVAALIEATSVHDRGLG PVLCAHGLTPEVVAIASNHGGKALE L EVVAIASHDGG TVRLLPVLCAHGLTP GRPALESIVALKSRAPLDEPTAVLARALLLTPVLCAHGLTPEVVAIASNGG LPHA NDHLVALACLGGRPALDAVKKG SEPAILDIKNROTNRRIPERTSHRVA TEAXLPE__2H1TT_ TCGTCGTGCTGCTGCTGCTGPAALASVDHLPRATALLG: GYTS777 VAVKYEKDIMKIPAKAVLRPSETAVAHHEALVGHGFTHAHIV SE IDNO:756 ALLTVAGELRGPPLLDTGLLKIATHEAIVGVGKWSGARALE APLNLTPEVVAIASNGGGKALETKVRGRGLVLTPAVVLECAVAHAWRNALTG AIASNHGGKALETVRLL HGLTPEVV LET PVLCAHGLTPEVVAIASHDGGKA CAVHGRLLTLPPEVLVCVAAIHAGSLNTPEVVAIASNGGGKALETVRLLPVL VAIASHDGGKALETVHRGLGLKPVALLCETAVHGRLLTLPPVLCAHGLTPEV ALETVRLLPVLCAHGLTPEVVAIASNHGEGKVVAALIEATSVNGRGLGLKPV LVCVAAA LIH EAG TSL VNTGP RGE LGLKVV PVAA LLI CEATS AVHD HGRG LLG TLK PPEVALL VCET VAAV IHAGR SLL HTL DPP GEVL GKVCVAAA LIH EAG TSL VNTHP RGE LGLK VLCAHGLTPEVVAIASNGGGKALETVRLLPVLCAHGLTPP VVAIASNHGGKALETVRLLPVLCAHGLTPEVVAIASHDE KALETVRLLPVLCAHGLTPEVVAIASNGGGKALETVRGLG PVLCAHGLTPEVVAIASNHGGKALETVRLLPVLCAHGLL EVVAIASHDGGKALETVRLLPVLCAHGLTPEVVAIASNTP GKALETVRLLPVLCAHGLTPEVVAIASNHGGRPALESGG LSRPDPALAALTNDHLVALACLGGRPALDAVKKGLPH IVA NRRIPERTSHR APALIKRT TEAXLPE__2H2TT_ GTCGTCGCTGCTGCTGCTGCPS AAEAVDILDRTNLOG:VA YS778EKIKPKVRST ALSHPAALGTVA VAHHEALVGHGFTHAHIV SE IDNO:757 VKYDMIAALPEATHEAIVGVGKWSGARALE ALPLLTNVLATGPEELRVGVPAPILASLNDHTGGGKLLAKLIEATKVRGRGLVLTPAVVLECAVAHHAGWLRTNPALTG AIASHDGGKALETVRLLPVLCAHGLTPEVVAIASNGEVV LETVRLLPVLCAHGLTPEVVAIASNHGGKALETVRGLGKA CAHGLTPEVVAIASHDGGKALETVRLLPVLCAHGLLPVL VAIASNGGGKALETVRLLPVLCAHGLTPEVVAIASNTPEV ALETVRLLPVLCAHGLTPEVVAIASHDGGKALETVHGGK LCAHGLTPEVVAIASNGGGKALETVRLLPVLCAHGRLLPV VVAIASNHGGKALETVRLLPVLCAHGLTPEVVAIALTPE ALETVRLLPVLCAHGLTPEVVAIASNGGGKALETSHDGGK VLCAHGLTPEVVAIASNHGGKALETVRLLPVLCAVRLLP VVAIASHDGGKALETVRLLPVLCAHGLTPEVVAIHGLTPE KALETVRLLPVLCAHGLTPEVVAIASNHGGKALASNGGG PVLCAHGLTPEVVAIASHDGGKALETVRLLPVLCETVRLL EVVAIASNGGGKALETVRLLPVLCAHGLTPEVVAHGLTP GKALETVRLLPVLCAHGLTPEVVAIASHDGGRPAIASNHG LSRPDPALAALTNDHLVALACLGGRPALDAVKK ALESIVA NRRIPERT GLPHAPALIKRT SE IDSNHOR:VA779 , , , - . , . -, . . - , , -, , ., HTT_369 GACATT.AG . HTT_288 GAC GCAGGCCGGCTG 3074186 115 HTT_444 TGGGGGGGAGCAGCGAGTGTAACGAGTCTAAGGGGCC 33007744119926 11116 HTT_373 ATGCTGGGGACGGGGACATT 307 7 HTT_534 GCGGGGCGATGCTGGGGA 4200 118 HTT_520 GGCGGGGCGATGC CG 3074208 119 HTT_622 GGGCGGGG TGGGGAC 3074209 120 HTT_696 GG CGATGCTGGGGA 3074210 121 HTT_ CGGGGCGGGGCGATGCTG 3074214 122 HTT_773435 GGGGGGCGGCGGGGGGCGGCGGGGGGCGGCAGTAGTCGTC 33007744215 123 HTT_720 GGCGAGACGGGGGCGGGG 216 124 HTT_729 GGGCGAGACGGGG CG 3074225 125 HTT_715 GGGGCGAG GCGGGGC 3074226 126 HTT_716 GGC ACGGGGGCGGGG 3074227 127 HTT_726 GGGGCGGGGGGCGGCAGGAAGCAGCGGGGGGGGCGGC 33007744223301 11228 HTT_751 GGGGCGGGGCGAGACGGGGG 3074 9 HTT_630 TGAGGGGCGGGGCGAGACG 232 130 HTT_579 CTGAGGGGCGGGG G 3074235 131 HTT_644 CCCGTCTC CGAGACG 3074236 132 HTT_619 GCC GCCCCGCCCCTC 3074237 133 HTT_3 TGAGGGGCGGGGCGAGA 3074238 134 HTT_56837 GGTGCGTACGGGCCCCCGCCGCCTCGCACGTGCGAGGCGG 33007744240 135 HTT_551 AGGGAGGCCGCCTGAGGGG 246 136 HTT_569 CAGGGAGGCCGCCT C 3074247 137 HTT_521 CAGCAGGG GAGGGG 3074248 138 HTT_351 ACA AGGCCGCCTGAG 3074251 139 HTT_618 CACGACGACGAGGGGAGGAGGCGCCGCCGCCTCGTAG 33007744225523 114401 HHTTTT__656875 CCGTGGGCGGGGCACAGCAGGG 3074263 142 HTT_639 GGCCCCCGTGGGCGTCGGTGGCCCCGCCC 3074264 143 HTT_625 AGGCCGGGGCGGGGGCGACCAACGACGAC 3074266 144 HTT_700 GGCGTGGCGAGGCCGGGGCG 33007744226776 11445 HTT_714 GGGCGTGGCGAGGCC 6 HTT_712 G GGGGC 3074277 147 HTT_487 GGTGAGGCGGGTGGCGGCTGAGGCCGGGG 3074278 148 HTT_596 GGTAGGGGCGGTGGCGGCAGGAGGCGCCG 3074281 149 HTT_531 AGGTAGGGGCGTGGCGAGGCC 33007744228823 11550 HTT_613 GGTGAGGTAGGGGCG 1 HTT_561 G TGGCG 3074287 152 HTT_480 CGGCGGGTGGGGGTCGGATGGTAGGGGCG 3074292 153 HTT_533 GCGGGGGGCGGTGGTGGTAGGAGGTGATG 3074297 154 HTT_583 TGCGGGGGGCGTGGTGAGGAT 33007744229989 11555 HTT_421 GCGATGCGGGGGGCG 6 HTT_621 G TGGTG 3074303 157 HTT_629 GCGGGTGGGGGCCGGATTGGCGGGGGGCG 3074308 158 HTT_574 CGGGGGGCGTGGCGGCAGTAGTCGGCGGG 3074313 159 HTT_572 GCGGGGGGCGTGGCGATGCGG 33007744331145 11660 HTT_376 TGCGGGGGGCGTGGC 1 HTT_184 A GATGC 3074316 162 HTT_488 GTGGGCAGGGGGCGGGTGGCGTGGCGATG 3074317 163 HTT_329 AGGGAGGCGTGGCGGCAGTAGTCGGCGGG 3074330 164 HTT_208 AAGGGAGGCGTGGCGATGCGG 33007744333312 1165 HTT_110 TAAGGGAGGCGTGG 66 HTT_218 CGATGC 3074333 167 HTT_186 GATCATAGGCGAGTAGGGGCGTGGCGATG 3074334 168 HTT_39 GCGGGACTGTCAAATGGGGGTAAGAGGCGG 3074342 169 HHTT_99 GGGGCGGGACTGCATGGTAGA 33007744334570 117701 HTTTT__259454 CAGGGGGCGGGACTGCATGGTA 3074351 172 HTT_680 GGGAGCAGCAGGGGGAGACGGGGACTGCA 3074356 173 HTT_693 GGGACGAGGAAGGGGAGCAGCGGGGGGCG 3074365 174 HHTT_570 GGCGGGACGAGGAAGGGACG 33007744336669 117756 HTTTT__566849 AGGAGCGGGACGAGGAAGGGAC 3074370 177 HTT_215 CGGGGCCGGAGGGGACCGGGAGGAAGGGA 3074371 178 HTT_452 GCGGCGAGGCGGGAGCAGCAGGAGGAGAA 3074375 179 HTT_107 TGTCGCGGCGAGGCGGGACG 33007744337860 118801 HHTTTT__6263 GTTGGTAGAGTGTCGCGGCGAGGC 3074386 182 HTT_34 GTGTAGATGGTAGATGCTGGCTGCGCGAGG 3074387 183 HTT_361 AAGCTGTGTGTGAAGGCTGGGTCCGG 3300774390 184 HTT_404 GGTGAGACT 4395 185 HT GTAATGGGGTG 3074420 186 HTTT__51009 GGGGCGGCTGGGTGAGACTGTAATG 3074425 187 HTT_138 GGGGCTGGTGGTGGTAGGAAGCATGTAAT 3074426 188 HTT_543 AACGGAGAGGGGACCGTGGGTGACAG 3300774427 189 HTT_334 GGCTCAACG 4441 190 HT GAGAGGGGACG 3074446 191 HTTT__442656 GGGGGGCGTCAACGGAGAGGGGAC 3074447 192 HTT_198 GCGCCGTGCGAGACCTGCGAAAGAGGGGA 3074448 193 HTT_225 GGCGCGGGGCTCACAGCGGAGGAAGGA 330074452 194 HTT_60 AGGCGCGGG 74453 195 HT GCTCAACGGAG 3074454 196 HTTT__18086 GTGTCGGAAGAGGCGCGGGGCTCAA 3074459 197 HTT_270 TGAGCCCCCCCCGGCCGGCCCCTTTCGCC 3074462 198 HTT_354 GCCCCGCGCCTTCGTCCCGCCGCGCG 3300774463 199 HTT_249 CCCCGCGCC 4466 200 HTT TTCGCCCGGGT 3074467 201 HTT__125161 CGCCCCGCCCGCCTTCGCCCGGGTG 3074468 202 HTT_111 GCAGCAGCCCCCCGCGAGCCCGCAAGGCG 3074469 203 HTT_707 GACAGCGCAGCGCCGCGCGACCGCAC 3300774474 204 HTT_182 TGACAGCGC 4480 205 HT AGCGCCCCACC 3074481 206 HTTT__548292 GGTTGCGAGGCGCTGCGCTGTCAG 3074485 207 HTT_436 AGGTGTCCGTGGCCCCTTTCGACTGTGTG 3074500 208 HTT_442 GCTGTGTGAGGCACGAACAACGCCTAG 330074508 209 HTT_494 CTGTGTGA 74512 210 H GGCAGAACCTGC 3074513 211 HTTTT__314982 TGGTTGGTGAGGCAGAACCTGCG 3074514 212 HTT_448 GAGTGGCAAGGGACAACGCATACCTGCGG 3074515 213 HTT_431 AGGCAGAACCTGGCCGGGGGGGGGGCCA 33074519 214 HHTT_504 GGCAGAACCTGCGGGGGCAG 3007744552201 221156 HTTTT__661115 AGGAAACCTGCGGGGGCAGGGG 3074524 217 HTT_636 CAAGCCCCTCGGCCGCGCGCGGCAGGGGC 3074525 218 HTT_701 CTGCGGGGGCATGGGCGCGCCCGCGGGCC 3074528 219 HTT_506 GCAGGGGCGGGCTGGTTCCC 33007744552397 222201 HHTTTT__348652 CATGGTTCCCTGGCCAGCCAT 3074548 222 HTT_381 GCATCCTTCGTCGCCACAATGGCTGGCCA 3074554 223 HTT_128 CTGCGGACTCATTGGCGCCATAGTGGCGC 3074555 224 HTT_269 CAGCCATTGGCAGAGTCCGCC 33007744556601 2225 HTT_126 TAGCCTGCGGACTC 26 HTT_153 TGCCAA 3074564 227 HTT_267 ATTTTGGGGCCAAGGAAGGTCCGCAGGCT 3074566 228 HTT_299 TGATTGACATGCCCCGCCTAAGGGCCCTA 3074567 229 HTT_82 GCTAGGGCTGTCAATCATTGGC 33007744557873 2230 HTT_185 GGGCTGTCAATCA 31 HTT_17 TGCTGGC 3074587 232 HTT_600 GCTGCGACAGTGCAAGTGGCTGGCCGGCG 3074592 233 HTT_311 CGGCGTGGCCCGCGCGGGCCCCTACCCGC 3074606 234 HTT_407 TGGCCCCGCCTCCGCCGGGCCG 33007744660172 235 HTT_446 ACGCTGCGCCGGC 236 HTT_40 GGAGGCG 3074635 237 HTT_3291 GAAGCAGCCGTCGTCGGCCGGCGGAGGC 3074636 238 HTT_252 GCCTCCGCCCGGCGCCGGGCCAGGGCAGG 3074637 239 HTT_247 CCTCCGCCGGCGCAGCGGTTCCT 3300774466349 240 HTT_137 CGTCCCAGACG 0 241 HTT_ CTGCGCCGG 3074643 242 HTT_42472 TGTGGCCGGCTACGCCAGACGCTGCGC 3074646 243 HTT_179 GTCTGGGCAGCTGCCTAGAGGGGACCGCA 3074648 244 HTT_74 TCTGGGACGCAAGGCGGCCCCGGT 3300774466556 245 HTT_79 CTGGGACGCAAGG 7 246 HTT_96 CGCCGTG 3074658 247 HTT_518 TCGAGAGGAGCCGGCCACAGGCGCCGTGG 3074659 248 HTT_509 AAGGCGCCGGTTGGGGGGGGGGCCTTGGC 3074666 249 HTT_586 CGCCGTGGGGGCTGCCGGCGCA 33007744666771 250 HTT_547 GCCGTGGGGGCTG 251 HTT_46 CCGGGAC 3074672 252 HTT_415 ACCTCGCCGCTGCGCGCAGGCAGCCCCCA 3074673 253 HTT_40 CGTCCATCTCTGGGGGATCCCCCAGATGCA 3074682 254 HTT_78 CGGGACGGGTCCAAGATGGCA 33007744668856 22555 HTT_19 TCCAAGATGGACGGCC 6 HTT_46 ACC GCTC 3074695 257 HTT_428 AGGTTGAAAGACAGGGCCACGGTCCATCT 3074696 258 HTT_308 TGAATGGGGCTCATAGCGCGTCGCAGGC 33074709 259 HTT_279 GGGGCAATGAATGGGGCTCT 3007744772396 226601 HHTTTT__357003 CCGAGGGCAATGAATGGGGCTC 3074737 262 HTT_232 CAGGACGACCCCCGCGAGTGTCATTGCCC 3074738 263 HTT_141 TCAGCACCGGGCGACAATAGTAGAATAGT 3074743 264 HTT_248 CTCAGCACCGGGGCAATGAA 33007744774445 22665 HTT_76 TTCATTGCCCCGGTGC 6 HTT_233 CG TGAG 3074748 267 HTT_114 TCCGGCGGCGGCCGCCGCCGTCAGCACCG 3074755 268 HTT_158 CTCGCGGCGCCCGTCCTACGACGACCACC 3074756 269 HHTT_90 TGCTGAGCGGCGCCGCGAGT 33007744775671 227701 HTTTT__41299 CGGGGACGCCGCGAGTCGGCCCG 3074768 272 HTT_134 GCGGAGGCTCCTGCGGCGCGCCCGACTCG 3074773 273 HTT_229 CGAGTCGGCCCGGAAGGGGCCCCTTCCC 33074775 274 HHTT_239 GAGTCGGCCCGAGGCCTCCG 3007744777767 227756 HTTTT__331103 CAGCGCAGTCCCCGGAGGCCTC 3074784 277 HTT_230 GCGCGTCCACGGTGCGCGCACGGAGGCCT 3074785 278 HTT_227 CCTCCGGGGACCTTGGCCCCGGTTGGCCC 3074790 279 HTT_150 CCGGGGACTGCCGTGCCGGG 33007744779914 22880 HTT_394 CGGGGACTGCCGTGC 1 HTT_61 TG CGGGC 3074795 282 HTT_73 TGGCCCGGGGTGCCTGCGCGCAGCCCGGCA 3074804 283 HTT_85 CGCCATGGCGGTGCATCCCCGCCGCCAC 330074807 284 HTT_165 GGAGACCG 74809 285 H CCATGGCGACCC 3074816 286 HTTTT__422806 GGAACACCTGGAAAAGCTGATGA 3074831 287 HTT_511 CTGGCGTAGCCTTTGGGAAGAGGACTCGA 3074854 288 HTT_552 GCTGCTGCTGGAGAGGAGCATCTTGTAG 33074863 289 HHTT_728 CTGCTGCTGCTGCTGCTGGA 3007744886742 229901 HTTTT__1770 GTCGTAGGCTGCTGCTGCTGCTGC 3074876 292 HTT_740 AGCTGGAAGGGGCAGGGGCCGGGCGGCGG 3074952 293 HTT_711 GGAAGCTGAGGAGGGCCGGGGCCGGGG 330074955 294 HTT_731 TGAGGAAG 74958 295 H CTGAGGAGGCGG 3074961 296 HTTTT__772242 GGGGCCTGAGGAAGCTGAGGAGG 3074964 297 HTT_669 GGCGGGGCCTGGGACGTGGAAAGCTGAGG 3074967 298 HTT_556 GCTTCCTCAGCCGGGCACAGGCCCTGGC 33074970 299 HTT_657 TGTGCCTGCGGCGGCGGCTG 3007744997759 330001 HHTTTT__555590 AAGGCGGCTGTGCCTGCGGCGG 3074985 302 HTT_638 GGCCAAGGCCGAGGCCTGGGTGCCTGCGG 3074988 303 HTT_687 GGCTGCGGCTGCATGGGTCGACGCCTAGG 3074991 304 HTT_756 GGCGGGGGCGGCTGCGGCTG 33007755000132 33005 HTT_607 AGCCGGGCCGGGTGG 6 HTT_623 C CGGCG 3075040 307 HTT_571 AACGACGCCGCGGGGCGCCGGGTGGCGGC 3075041 308 HTT_594 GCCGCCACCCCGGGGCGCTCGGGGCCGTG 3075042 309 HTT_576 GCCACAGCCGGGCCGGGTGGG 33007755004445 3310 HTT_527 TCAGCCACAGCCGG 11 HTT_471 GCCGGG 3075048 312 HTT_542 ATCCCCCTGCGACGCCCCGGCTGTGGCTG 3075050 313 HTT_558 CTCCTCAGCACCAACGACGCCGCGGGGCC 3075051 314 HTT_489 GCGGCTCCTCAGCCACAGGCCC 33007755005526 315 HTT_374 AGCGGCTCCTCAG 316 HTT_37 CCACAGC 3075057 317 HTT_20 CCAGACATCGTCCAACCCGGGTCGGTGCAG 3075075 318 HTT_45 GCTGCACCGAACCCCGGTTGGAAGGTTTTT 3075076 319 HTT_22 AGCGGGC 3075077 320 H CCAAACTCACGGT 3075083 321 HTTTT__95815 CCTCGCCGAGCGGGCCCAAACTCA 3075087 322 HTT_537 GCCGCGTGGACCAAGGCGTGCACCTGTCC 3075100 323 HTT_565 GCTGCAGCTCCCTGGCTTCGCCCAGGG 330075101 324 HTT_479 CTGCAGCT 75103 325 H CCCTGTCCCGGC 3075104 326 HTTTT__336454 TGCCCCCTGTCCCGGCGGGTCCC 3075111 327 HTT_260 AGCTCGTGGGGAGCACCCCGCCCGGGACA 3075112 328 HTT_206 TCCCGGCGGGTCGCCCCAGGGGGCATCA 33075113 329 HHTT_124 GCCGTAGCCTGGGACCCGCC 3007755111178 333301 HTTTT__129807 CCGGCCGTAGCCTGGGACCCGC 3075119 332 HTT_294 GGGCCGGGGGGTTCCCCCCAAGGCTACGG 3075120 333 HTT_169 GCGGGTCCCAGGGGCCTTAACCGGGGCCG 3075121 334 HTT_347 GTCCCAGGCTACGGCGGGGA 33007755112226 33335 HTT_67 CGCCATCCCCGCCGTA 6 HTT_352 CC GCCT 3075128 337 HTT_368 GGACGGGGCTTAAACCGCGCCGGGGATGG 3075129 338 HTT_245 GCGGTAACCCTTGGCCAAGGCCCCTTGGC 3075147 339 HTT_293 TAACCCTGCAGCCTGCGGGC 33007755114582 334401 HHTTTT__332556 TGCTGCCGGCCCGCAGGCTGCA 3075155 342 HTT_27 GGCTGTCCCGGTGGCTCCCGGCCAGGCTGC 3075156 343 HTT_86 GGGCCGGCGACACCGGGACACCCCGCCC 330075163 344 HTT_130 GGGCCGGG 75168 345 H GGTTCGTGTCGC 3075171 346 HTTTT__428139 CATCCTTGTCTCTGCGGGGCCGG 3075184 347 HTT_281 CACCTTCGTTGCTTCCTTCGTCGGGGCCG 3075185 348 HTT_397 TCACTCTGTCTCGTCGGCGGGGGGCGCC 33075186 349 HTT_231 TGGGTCA 075187 350 H CTCTGTCTCTGCG 3075191 351 HTTTT__464555 CGTCGTGGTCACTCTGTCTCTGC 3075192 352 HTT_562 CTCGAGTGGTGCGACCTTCCTTGTCTCTG 3075193 353 HTT_437 CCAGCAACCCAGGAGGGCTCTCGACTTG 33075210 354 HTT_440 CAGCAAC 075211 355 H CCAGAGCCCATGA 3075212 356 HTTTT__411167 GCGGGGTGTCCCTCATGGGCTCT 3075218 357 HTT_290 AGGGGTGGGTCCGCGCGTTCGATGGGCTC 3075219 358 HTT_375 GAGGGGGCGGGTTGCTCCCCTCCTACTA 33075225 359 HTT_408 GAGGGAC 075226 360 H ACCCGCCCCCTCC 3075230 361 HTTTT__335530 AGGGGGGACACCCGCCCCCTCCT 3075231 362 HTT_367 ACCACCGACCCCCCCGCCTCCCCCTCCTG 3075232 363 HTT_522 GCCTCGCCCCAGCGTAGGGGGGGGCGGC 33075237 364 HHTT_628 GGCCTCGCCCCAGGAGGGGG 3007755223389 336656 HTTTT__451575 GGAGAGGCCTCGCCCCAGGAGG 3075242 367 HTT_463 GGAGAAGAGGCGCCTCCTGCCCCCAGGAG 3075243 368 HTT_484 GGGGAAGGCCTGCCGCCCCCCACGAGGAG 3075244 369 HHTT_541 GTGGGGGAAGGCCTCGCCCC 33007755224458 337701 HTTTT__650832 AAGGCGGGGCTGAAGTGGGGGA 3075260 372 HTT_595 GAGGGGAGGACGGCGGGGGGCTGAAGTGG 3075264 373 HTT_474 TGAGGGAGCGGGGCGTCGTAGAAGATGGT 3075265 374 HHTT_560 GTGAGGGAGCGGGGCTGAAG 33007755226667 337756 HTTTT__452369 TTTCCAGCCCCGCTCCCTCACT 3075271 377 HTT_277 AAAGGACCCCCCCAGACGTTCCCTCACTT 3075272 378 HTT_102 TCTTCCCTTGTGCACGTGCGTACGGCCGG 3075276 379 HTT_200 CTTCCCTTGTCCTCTCGCGA 33007755229956 338801 HHTTTT__13280 TCTTCCCTTGTCCTCTCGCGAG 3075297 382 HTT_58 CCCTCTCGCTTCCCGTCCGTACGAGGACAA 3075299 383 HTT_306 GCTCTGCCTCCCGCCTGCAGGCGGGAGG 33075300 384 HHTT_573 GAGGGGAGGCAGAGCCTTGT 3007755330164 338856 HTTTT__449730 AGGGGGGAGGCAGAGCCTTGTT 3075315 387 HTT_194 ATGTGCAAGGGGCAACGAAGGCCTTGTTG 3075316 388 HTT_212 GGCCTGTCCTGGACACTCTCCAAACCCAG 3075328 389 HTT_160 GCCTGTCCTGAATTCACCGA 33007755333378 33990 HTT_94 CCTGTCCTGAATTCAC 1 HTT_113 TG CGAG 3075339 392 HTT_51 GAAACTTTCCCACCCCTGCAGGGTGAATTC 3075344 393 HTT_331 GCTGAGGCCGTGGAGCGTACGCTCCCAT 33075347 394 HHTT_461 TGCGAAGGGCGAGAGGGCTG 3007755335740 339956 HTTTT__210175 TGCCAGCCCTCTCGCCCTTCGC 3075372 397 HTT_63 CGACTACTCCTCGTCGGCAGAAGGGCGAGA 3075376 398 HTT_59 AACTCTTCGCATACGCGTGGCCGGAAGA 330075377 399 HTT_29 CAACTCTTC 75384 400 HT GCATCCTGCGA 3075385 401 HTTT__41332 CTTTTCCGGCAGGATGCGAAGAGT 3075386 402 HTT_145 TCGCCAAGGGGAATTGGCCGGAAAGAGTT 3075387 403 HTT_276 TTATTTGCGAGAAAAGCACGATGTGGG 330075388 404 HTT_265 TATTTGCG 75428 405 H AGAAACCAGGGC 3075429 406 HTTTT__81103 ATTTTTTGGCGAGAAACCAGGGCG 3075430 407 HTT_151 AGTTCAGAAAGAAGAAAACCCCAGGGCGG 3075431 408 HTT_149 ACTGCGTTGTGAACGCACGGACACCCT 330075442 409 HTT_53 GCGTTGTGA 75462 410 HT AGAGAACTTGG 3075465 411 HTTT__344793 ACATGCTAGGCACTGAGCAAATCT 3075490 412 HTT_284 CTTCGCACCTTCATGTACATGAAGGGAAG 3075507 413 HTT_430 TTCCCTCTTCTAGGTTCCTTGGAAGGA 330075510 414 HTT_322 TTCCCTCT 75511 415 H CAGACTAGAAGA 3075513 416 HTTTT__332843 CCTTTTCCCTCTCAGACTAGAAG 3075514 417 HTT_645 TTCCTTAAGGTTCCTTGGAAGGAGGGAAG 3075517 418 HTT_647 AGTCTGAGAGGGAAGAGGGAAGAGGGAC 33075518 419 HTT_593 GTCTGAGAGGGAAGAGGGCT 3007755552223 442201 HHTTTT__665740 TCCTTGAGAGGGAAGAGGGCTG 3075524 422 HTT_710 AGGGAGGAAAGGGAGGAGAGGAGGGCTGG 3075525 423 HTT_692 GGGAAGAGGGCCTTGGGGGGGGGGCCGGC 3075530 424 HHTT_21 GGGGCGCGGGACACTTCGAG 33007755553414 442256 HTTTT__32105 GCCGGGCGGGACACTTCGAGAGG 3075547 427 HTT_312 GGGGAACCAACCTTTTCCGGAAGAGGAGG 3075550 428 HTT_159 GGACACTTCGAGGAAGGGGAAGGGGCCG 33075551 429 HHTT_183 CTTCGAGAGGAGGCGGGGTT 3007755555527 443301 HTTTT__660352 GGAGGGAGGCGGGGTTTGGAGC 3075563 432 HTT_546 GTTTTTTGGGGAAGGCCTTGGGAGAGATG 3075573 433 HTT_554 TTTGGAGCTGGGAAGGAAGGAATTGGTTG 3075574 434 HTT_601 TTGGAGCTGGAGAGATGTGG 33007755557756 44335 HTT_652 CTGGAGAGATGTGGG 6 HTT_68 TT GGCAG 3075582 437 HTT_413 GGAAGCGGACCCGTCCCGTGCGGCGGGAG 3075619 438 HTT_237 GACGCCTCGGCCGGGGGGAAGGTTGGGGC 3075622 439 HHTT_123 ACGCCTCGGCGGGAGTGGCG 33007755662234 444401 HTTTT__551435 CCTTGCCCCGCCACTCCCGCCG 3075627 442 HTT_475 TCCGGGGCCGGGGGGAAGGTTGGCGGGGC 3075628 443 HTT_666 CGGCGGGAGTGGGGCCGGGGGGGGCCAAG 3075629 444 HTT_697 GGCGGGAGTGGCGGGGCAGG 33007755663301 44445 HTT_706 GCGGGAGTGGCGGGG 6 HTT_705 C CAGGG 3075632 447 HTT_754 GGGGGGAAGGTTGGGGCCGGGGGCAGGGG 3075633 448 HTT_735 GGAGTGGCGGGGGGGCCAAGGGGGGGGGG 3075634 449 HTT_762 GTGGCGGGGCAGGGGGGGGGG 33007755663358 44550 HTT_744 TGGCGGGGCAGGGGG 1 HTT_721 C GGGGC 3075639 452 HTT_746 AAGGGGGGGGGGGGGGGGGGCGGGGAGTG 3075647 453 HTT_89 GGGAGTGAGGCGGCGGGCGGATGCTCGAAA 3075648 454 HHTT_28 GGAGTGAGGGCGCGTCCAAT 33007755666601 445556 HTTTT__443459 TTATGGAAAAGAAATCTCCCAT 3075676 457 HTT_255 TAAGAGAAAACGAAGGCCCCTGAGATTTG 3075706 458 HTT_309 GAGGCTCTTCCTTCAACAAATTTCGTTCC 3075715 459 HTT_323 ATGAAATGTCCTGACAATGT 33007755772354 446601 HHTTTT__512668 TCTTCATTTAGTTCATGATCA 3075751 462 HTT_220 AAGTATTTGAAGGTCTACGATGATCACGG 3075754 463 HTT_464 CTTAGATGAGACTACGTACTTCTTACGTG 3075797 464 HTT_64 CTGCTCATCTAAGCCTAAGTT 33007755880100 44665 HTT_25 CTAAGCCTAAGTTGG 6 HTT_65 AA TCTGC 3075818 467 HTT_171 GCAACGGGCCCGTTGTCTAGGACCAACTT 3075823 468 HTT_371 GTTGTGGTTGCACAATAGGATGATATAGG 3075836 469 HHTT_32 CGTAAGTTCACCACTTTACT 33007755885622 447701 HTTTT__46863 AAGTTAAAGTGGTGAACTTACG 3075865 472 HTT_125 TAGAAAAAACTCTAAATCCATTAAATATT 3075894 473 HTT_101 AAAACCAACACCGGTTTTGGCCTTGGAAT 3075956 474 HHTT_55 AAACCAACACGTTGCTGATG 33007755995578 447756 HTTTT__4797 CGCAATACACGTTGCTGATGGGG 3075961 477 HTT_36 ATGGGGGGGGAAGGGGTTTTAAAATTGCCG 3075974 478 HTT_93 TAATTGCCGAGGGTATTGGCACAGTAG 3300775975 479 HTT_343 TGTACACCT 5985 480 HT CATTCATCCCT 3075991 481 HTTT__118209 GCGGCTAAGCCTGACTGGAATAC 3076019 482 HTT_155 CAGATTCTACGTGGCGTCTAGAGCCTGAC 3076027 483 HTT_204 AGTCAGGCTTGCCCCAAGGAAAATTAAC 33076028 484 HTT_24 GTCAGGCT 076029 485 H TGCCAGAATACG 3076030 486 HTTTT__7457 TCCAAGGGGCTTGCCAGAATACGG 3076031 487 HTT_33 TCTGCCTGTGGACCCCACGCACACTACGGG 3076032 488 HTT_80 CGGGGGGTCCGCAGGATCATTCTCCG 33007766040 489 HTT_54 GGGGGGTCCGC 048 490 HTT_ AGACTCCGT 3076049 491 HTT_448053 TTGGAGGCAATGCCCACGGAGTCTG 3076056 492 HTT_268 ATCTCCAAGTACTTGGTAGGCACTGCCCA 3076065 493 HTT_256 TCTCAGATGTGCCAAGGTTGGAAAAA 3300776073 494 HTT_266 GCAAACAGA 6074 495 HT AACCCTTTCAC 3076085 496 HTTT__453841 GGGGGTTTTCTGTTGCTTGTTCT 3076144 497 HTT_641 GTTTTTCCTTGGTTTTGGCCTTTGTTCTT 3076145 498 HTT_263 GAGACCATTAAATAGCTATTCCTTTAGG 33076146 499 HTT_224 AAAACATCTAGCGGAACCCC 3007766129021 550001 HHTTTT__241575 CGGAGAACCCCAGGACTTTCCC 3076212 502 HTT_379 AGCATCTTCTCCACGAGGGGAAAGTCCTG 3076217 503 HTT_502 CAGACTTCCAGGGAGAAAAGATGCTCCTC 3076218 504 HTT_193 ACTCGACACACAGACTTCCA 33007766221299 55005 HTT_273 CACTCGACACACAGA 6 HTT_148 C CTTCC 3076230 507 HTT_84 TTCGGTAGGTTGGTTCAGCAAGTGTACAGT 3076239 508 HTT_240 GTAGGAGTTAGGGTAAAGGGTAAGCTTTC 3076246 509 HHTT_140 GAAGTACTCTGGTGCAGTTC 33007766225678 551101 HTTTT__511627 AAATTACTGAGAGGTAAGAGAA 3076291 512 HTT_69 TCCAGGGTAAATATTCATGAATATACTGAG 3076302 513 HTT_144 CATCTGGGACACTATTCCCCGAAGTACT 33076306 514 HTT_56 CGATCTGG 076320 515 H ATGTGTCCCAGA 3076321 516 HTTTT__138674 GAATTTGTGTCCCAGATGGCATT 3076328 517 HTT_228 TATCTTCTTATCACCACAAAATGCCATCT 3076335 518 HTT_610 AGTTTAATTAGAAATAGACTCGAATTCT 33076336 519 HTT_320 AGCAGTG 076435 520 H TTAGCTTATTTGT 3076460 521 HTTTT__654597 TTATTATTGTTGGAATAAAATTT 3076473 522 HTT_566 GAAGTGAAAAATTATAAATTTTATTCTAA 3076491 523 HTT_427 AAAGCACTACAGCTTAAAAAATGTGTAC 33076495 524 HHTT_131 ATCTTGTGTAAACACTAAAC 3007766568581 552256 HTTTT__424614 TACCTTGTGTAAACACTAAACA 3076652 527 HTT_214 CAACCTTAAAAAACCAAGGGGGCTCCTGA 3076662 528 HTT_482 AAACAGGGCTCGCCTTGCACTTGGGAGTA 3076663 529 HHTT_390 TCTGAAGCAGCCCAGCAGAA 33007766666974 553301 HTTTT__675069 AAATATCAGCATAAGAAAGAGA 3076740 532 HTT_661 TTTTTGGCCTTTTAATTCCTTTCAAAATA 3076775 533 HTT_459 TTCCTTTGCTGTCCCATATAGAATCAATA 3076776 534 HHTT_451 CTCCTTTGTCAAGGCAGCAA 33007766881102 553356 HTTTT__466892 ACATAATCTATCTCCTTTGTCA 3076821 537 HTT_686 TTTAAATATATAAAATATATAATTTAATC 3076875 538 HTT_500 AAATTTAATCAAGAGTACCATGGGGACCA 3076880 539 HTT_283 TTTAATCAGGACTGGCAAGG 33007766888858 554401 HHTTTT__776778 CAACCCTTTAATCCGAGCACTT 3076915 542 HTT_769 TCCCTCTATAAAAGTTCGCCGAGCACTTT 3076916 543 HTT_780 TTTAATCCGAGTCCAGCGTATTTTGAGAG 3076917 544 HHTT_787 CCGAGCACTTTGGGAGGCCT 33007766991295 554456 HTTTT__871976 ACGTCACTTTGGGAGGCCTAGG 3076928 547 HTT_750 CTCAAGGGGTTGGGAATCTGCGTCCACCT 3076942 548 HTT_779 TGGACGAATCAACACTTCGAACGCGTTGC 3076943 549 HHTT_825 GGTCTCAAACTCCTGACCTC 33007766994589 555501 HTTTT__872929 TTCGAGGAGTTTGAGACCAGCC 3076966 552 HTT_783 TTATGCAACCCCAAGTCGCTTGGCTAACA 3076975 553 HTT_792 AGGGTTTCACCTAATGGCTCTAAGGGCCC 3076980 554 HHTT_801 ATACAAAAATTAGCTGGTCA 33007767908240 555556 HTTTT__789173 CTAGAAAATTAGCTGGTCATGG 3077023 557 HTT_800 GCCCCTTGGTTAAAATTCCCCAAGCTACC 3077050 558 HTT_764 TCCCAGGTAGCATATGGCGTAATCTCATC 3077051 559 HHTT_808 TGTAATCCAAGCTACCTGGG 33007777005524 556601 HTTTT__788065 CGCCAAGCTACCTGGGAGGCTG 3077060 562 HTT_816 GCTAAGCGCATAGAGAGTACGGCTGAGGC 3077064 563 HTT_807 CAGGAAAATCGGCCTTTTGGAAAACCCCC 3077082 564 HHTT_776 GAAAATCGCTTGAACCCGGG 33007777008836 556656 HTTTT__881152 CTACCTGCAGACTCTGCCTCCC 3077100 567 HTT_819 CAACCGTCGCCAACGTAGCCTCTGCCTCC 3077101 568 HTT_821 ACGCCACTGCAACCTTCCCCAAGGCCCCT 3077132 569 HHTT_829 TCACCCAGGCTGGAGTGCAG 33007777113336 557701 HTTTT__872804 TACGTCGCTCTGTCACCCAGGC 3077146 572 HTT_535 ACAAGATACTTTCCGTCGTTCTGTCACCC 3077150 573 HTT_608 CAAATTCTGTAAAATTTTAACCAAAAAAA 3077232 574 HHTT_694 ACTCAGAGGAAAGGGGTGGA 33007777223734 557756 HTTTT__624802 AGGTGTACTCAGAGGAAAGGGG 3077278 577 HTT_414 AGTTATGAGGTGATCATCCTAGAGGAAAG 3077281 578 HTT_399 AAGTTAGGTACCTACGAAGGAGGAGAAAA 3077282 579 HTT_118 GGACAAAGTTAGGTACTCAG 33007777228838 558801 HHTTTT__443728 TTTGGATATACTTATGGTGGGCGTATCGAAAGTT 3077298 582 HTT_388 CTGAAA TTCTTG 3077309 583 HTT_3 TAGTGCTTGTTCTT 3077310 584 HTT_11483 ATCATTGAATACATTGAGGCTAGGCGTATTGATCTACTT 3077311 585 HTT_197 ATGAACAGGTT G 3077335 586 HTT_271 CAA ATATCTGGC 3077345 587 HTT_181 ATCTTAATTGCATATCAACGAGATTTAATTGAATACC 33007777349 588 HTT_759 GTAGTCTCACATTGTC 359 589 HTT_795 TCTCACAT ACCC 3077443 590 HTT_794 GTATCACTTGGCTACCATCCCCCAAGGCGCCT 33007777444670 55991 HTT_771 TGTATCACTGCACTCCAGCC 3 2 HTT_810 GGAGTGCAGTGATA 077461 593 HTT_788 CACTGCAGTCTCTGCCACATTCCCTC 33007777446983 559945 , . - , , , - , , , . ,, . HHTTTT__7748 TCCGTGGGGAG. CAGCGGGCTACACGAGACGGACTCGGGTA cchr4:307.4657 + Region2246 HTT_96 T hr4:3074686 + Region2 256 HTT_169GGCGGGGAGCTGCCCACAAGGCGCCGTGG chr4:3074659 + Region2248 HTT_232CAGCACCGGGGGGCCATAATCGGAGACG chr4:3075122 + Region2335 HTT_272GGCGCAGCGTCTGGGACGTCGA cchhrr44::33074743 - Region2264 HTT_428AGGTAAAAGCAGAACCTGAG chr4:3007744674089 +- RRegion2244 HTT_436AGGTTCTGCCTCACACAGCA chr4:3074508 - Reeggiioonn22225099 HHTTTT__565807 AGGGCCATGGCCGGGCTGTGCCTGCGG chr4:3074988 - Region2303 HTT_722 GGCGGCTGGCATGGGAAGAGGCCATGGCAAGGG cchhrr44::33007754090637 -- RReeggiioonn22320958 ,, ,,,,, . . , , , -, , .. , . -, . . , , , , ., FF12 CAAGGCCAAGG. CCAAGGCCAAGGCCAAGGCCAAGGCA + 596 F3 GCAGCAGCAGCAGCAGCCAAGGC ++ 559978 RR1 R2 CTTGGCCTTGGCCTTGGCCTTGGCCTTGGCCTTGGCCTTG -- 569090 F31_18nt GGCCTAGGCCTAGGCCTAGGCCTAGGCCTAGGCCTAGC -+ 601 F1_16nt AGCAGCAGCAGCAGCA 602 F1_14nt CAGCAGCAGCAGCA ++ 603 FF12__1128nntt GCCAAGGCCAAGGCCAAGGCCAAGCAGCAG + 6 + 60 6045 F2_16nt GCAGCAGCAGCAGCAG + 06 F2_14nt AGCAGCAGCAGCAG + 6607 F23__1128nntt CAAGGCC 08 F AAGGCCAAGGCCAAGGCAGCAGC ++ 66019 F3_16nt CAGCAGCAGCAGCAGC + 60 F3_14nt GCAGCAGCAGCAGC + 6111 F3_12nt AGCAGCAGCAGC + 6123 ,-. , - , , , - - , - - ,.-., - , - , - . , , , - , - - . - -., , - , - . ., . , ...,, . , , . , , , - - , ,- - .-., - , - , - . , - , , , - - .-., , -- , - . , , , , , - - , - ,- .-., - , - , - . , - , , , - - .-., - , - , - . , , . . , , , . , , . , . ., , – – – - -– – ..,,– – –, . -,,–– – – –– – -- , –, .., - ,. , ,–– – – ––, - -..,, . -,,– – –– - -– ..,,–, . -,,– – – – ––, - -..,, . - , , - , - , ,,,,,,, ,,,,- , ,,, ,, , . . - ,- .- . , - - “ ”. - . - - - , --- , --- , - - , - - - - - , - - . - , - - - - - . - , - , - . - , - , - - - - - . - ,, - -,,,,,,-, , , - . ,,,,,,, . , - -,,- , , , ,,,, , - . ,,,,,,, . , -- . -- . - - , - -. , , - , - . , - , , - - . , , - , - . -. , - , - , ,, - - .. , - , - - - - ., , , , - , . , , - , . ,- -. . , , . , , ,, ., . . , . - , . , . - , ,, ,., .., .. - , . . - -. , . - , . . –-.. , , .., , ,- , . , , . --, . . . . , . , , . - , . . , , , ., . . . - ’ - , , , . ’ -. , , ..,- ’ ’ . ’ , . , . -.- , ., . , . ,- , , , , . ,- ,. ,,,,,,, ..,, ,,,,,,,, , ,,,,,,,,,,,., . ,,, , ., . . . , , . , , , - , , . , . , - - - . . -,, - -,. , tTomato. - .- ’., ., . = , ,== ., , -- = . ,. , .- , - - , - - - -. - . - , - , -. . 2- -2., , . - . . -, .- -, - , -tTomato. - - , . - . - . ,tTomato- ,- t-Tomato-- . - , ,.tTomato- tT- - . .-omato- .t- - -Tomato- , .., ..,.,....tT_omato-, _ _ . _ . ,. . , -- - - - - . - - - . - , - - . . , -. -. -- - - , . -- -, . - -, - - - . , . , ., , -. , , -. , -. . , , .tTomato . - - . . tTomat. - , ,o. .   - ,__ _ - . - , , _,, _ . , , . - - - t.Tom, , .  , -ato- . , - , __ _ _ .  ,. , . -tTomato. - . .tTo--   , - -mato. , , , __ _, _,, _ , . ,, __ _, -__ _, __ _, , . - .-tTomato- . .  . , , - , ~_ .  . ._ _ , - -tTomato. - -- - - -, . , ,, -, .., . , .WT-Was - - .WT-- - - -Was W-T-tTomat,o. , . - , . - - -. - -WT-Was 1.-,-tTomato. - .- . , . .Was 1-tTomato, . , - -  ,, .- ,   , , , - -,, . , - , , . - - - . -WT-W- ,. - -as 1-tTomato- . - - _.  - , -, -. ,_- - , , , , -. - . - - - , -- . .., ,..,- - - - . . - - . - - -WT-Was. , - - - -1-tTomato---. -- , .. - - . ., -. s . , _ WT-WaWT-WaWsT-tTom-ato- - WT-W- , _ -- -as 1-tTomato-WT-Was WT-t- . - , - . ,Tomato, - - .WT-W, . - -- - ,as -tTomato-WT-Was 1-tTomato. , - - .- ’,. WT-Wa. s.,_ 1-tTo_ , . _, _-, _ - . -mato-  . __._ _ , .  , ~ , - . . ,___ ___, , , ., - - . - - - ’ , . - ’ - - .. - - - . , . . , , -- -- . . ,. ,- - - - . , WT-Was_._ 1_, _,- _, --tTomato-.  . ___. , . , ,   , ~ . , , . , - - - - -.’ , . - ’ - - -. - - . - . - - - , - , –. , . – — - , , — , WT-Was__1___._ - -,-tTomato- - -- , - . . ___ - , - -.., . - . ,- - -- , -~, . , , - . . . .- ,-. ,, - . , , __ _ ___-. , , ,- . ,- , - . , - . -, . , , - - .- . - - - - - . - - - - , — , —- , __ - ___ . _,tTomato. , -- - - , - . , , - - , - . - . , ,- ,. - - , - - . - -- . - - - - .-, , , - - , . - , - , . , - -

Claims

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Citation Information

Patent Citations

  • Gene silencing

    EP3995584A1

  • Methods and compositions for treating huntington's disease

    WO2015070212A1

  • Zinc finger protein compositions for modulation of huntingtin (HTT)

    WO2019204457A1

  • Engineered genetic modulators

    WO2020072684A1

  • Method for treating spinocerebellar ataxias (SCA) by targeting ATXN7 gene

    WO2022145495A1