Ameliorating composition for menstrual pain and / or menstruation-associated symptoms, and advisory information output program related to ameliorating composition

Abstract

[Problem] The present invention addresses the problem of providing a composition useful for ameliorating menstrual pain and menstruation-associated symptoms by using vinegar which can be safely ingested. In addition, the present invention addresses the problem of ameliorating menstrual pain and menstruation-associated symptoms using, in particular, acetic acid as an active ingredient. Furthermore, the present invention addresses the problem of providing a composition with which more effective amelioration in menstrual pain and menstruation-associated symptoms are expected, by using vinegar with little contents of components (for example, amino acids, lactic acid, minerals, and the like) other than acetic acid. [Solution] The problems are solved by an ameliorating composition for menstrual pain and / or menstruation-associated symptoms, the composition being characterized by containing vinegar. Preferably, the ameliorating composition for menstrual pain and / or menstruation-associated symptoms is for during, before, and after menstruation. More preferably, the vinegar in the ameliorating composition for menstrual pain and / or menstruation-associated symptoms is apple vinegar.

Description

Composition for alleviating menstrual pain and / or menstrual symptoms, and program for outputting advice information regarding the composition

[0001] The present invention relates to a composition for alleviating menstrual pain and / or menstrual symptoms, and a program for outputting advice information regarding the alleviating composition.

[0002] Various studies and proposals have been made to improve menstrual pain and menstrual symptoms that are unique to women. Some women experience a decrease in their quality of life due to discomfort and physical discomfort during their menstrual period, and have sought a way to solve these problems.

[0003] Medications and supplements have been developed to relieve common menstrual pain and symptoms, including painkillers and hormone therapy, but these may have limitations on long-term use and may have side effects.

[0004] In addition, in the fields of health foods and natural therapies using ingredients derived from specific herbs or plants, proposals and research have been conducted on the alleviation of menstrual pain and menstrual symptoms. For example, Patent Document 1 discloses that menstrual symptoms can be prevented, improved, or alleviated by selecting and combining three groups of herbal medicines with specific meridian properties and flavors. However, even in these fields, side effects and health concerns remain, and the effects vary from person to person, so it cannot be said that they are equally effective for all women.

[0005] Furthermore, Patent Document 2 discloses a composition for improving menstrual irregularities that contains acetic acid as an active ingredient. However, the composition is intended to improve menstrual cycles such as menstrual irregularities and amenorrhea, and is not intended for women whose menstrual cycles are generally regular, nor is it intended to improve various symptoms associated with menstruation.

[0006] On the other hand, vinegar, a brewed product, is known to contribute to the primary prevention of lifestyle-related diseases such as diabetes, high blood pressure, hyperlipidemia, cancer, and osteoporosis, and further development of its uses is expected.

[0007] JP 2022-071835 A JP 2008-247883 A

[0008] The present invention was made in consideration of these circumstances, and aims to provide a composition that uses vinegar and is useful for alleviating menstrual pain and menstrual symptoms, which can be safely ingested by women with generally regular menstrual cycles. Another aim of the present invention is to alleviate menstrual pain and menstrual symptoms, particularly by using acetic acid as an active ingredient. Furthermore, the present invention aims to provide a composition that is expected to more effectively alleviate menstrual pain and menstrual symptoms by using vinegar that contains little components other than acetic acid (e.g., amino acids, lactic acid, minerals, etc.).

[0009] The present inventors have conducted extensive research in light of the above problems and have found that vinegar improves menstrual pain and menstrual symptoms, thereby completing the present invention.

[0010] [1] A composition for improving menstrual pain and / or menstrual symptoms, characterized by containing vinegar.

[0011] [2] A composition for improving menstrual pain and / or menstrual symptoms during menstruation, characterized by containing vinegar. [3] The composition according to [2], wherein the menstrual symptom category is one or more of pain, negative emotions, PMS, and water retention. [4] The composition according to [3], wherein the items classified in the pain category are one or more of "lower back pain" and "easy fatigue." [5] The composition according to [3], wherein the item classified in the negative emotions category is "feeling depressed." [6] The composition according to [3], wherein the item classified in the PMS category is "loss of confidence, self-blame." [7] The composition according to [3], wherein the item classified in the water retention category is "swelling (abdomen, breasts, legs, etc.)."

[0012] [8] A composition for improving premenstrual symptoms, characterized by containing vinegar. [9] The composition according to [8], wherein the menstrual symptom category is one or more of pain, autonomic nervous system imbalance, water retention, negative emotions, PMS, other, behavioral changes, and elevated mood.

[10] The composition according to [9], wherein the item classified in the pain category is "easy fatigue."

[11] The composition according to [9], wherein the item classified in the autonomic nervous system imbalance category is "hot flush." ​​

[12] The composition according to [9], wherein the item classified in the water retention category is one or more of "rough skin," "swelling (abdomen, breasts, legs, etc.)," ​​and "weight gain."

[13] The composition according to [9], wherein the item classified in the negative emotion category is one or more of "feeling like crying," "feeling anxious," "feeling lonely," and "feeling depressed."

[14] The composition according to [9], wherein the item classified in the other category is "constipation."

[15] The composition according to [9], wherein the item classified in the behavioral change category is "decreased work or study efficiency."

[16] The composition according to [9], wherein the item classified in the mood enhancement category is one or more of "becoming more active" and "becoming more obedient."

[17] A composition for improving one or more of the temporary premenstrual symptoms of "changes in sleep habits: insomnia," "depressed mood," and "changes in sleep habits: drowsiness," characterized by containing vinegar.

[0013]

[18] A composition for improving menstrual symptoms after menstruation, characterized by containing vinegar.

[19] The composition according to

[18] , wherein the menstrual symptom domain is one or more of negative emotions, pain, and elation.

[20] The composition according to

[19] , wherein the item classified in the negative emotions domain is "feeling depressed."

[21] The composition according to

[19] , wherein the item classified in the elation domain is "feeling happy."

[0014]

[22] The composition according to [1], [2], [8], or

[17] , wherein the menstrual symptoms are a collective term consisting of the following attributes and items: Pain: lower abdominal pain, lower back pain, headache, body aches, stiff neck and shoulders, fatigue; Decreased concentration: awkward movements, decreased concentration, poor judgment, forgetfulness, difficulty organizing thoughts, distractibility, insomnia, frequent failures such as cutting fingers or breaking dishes; Behavioral changes: falling asleep or going to bed, loss of perseverance in work or study, decreased efficiency in work or study, laziness, wanting to avoid socializing; Autonomic dysfunction: hot flashes, cold sweats, vomiting Nausea, dizziness. Water retention: breast pain, rough skin, swelling, weight gain. Negative emotions: wanting to cry, feeling anxious, lonely, irritable, moody, depressed, easily tense, restless. Elevated mood: easily excited, active, feeling happy, gentle, obedient. Control: ringing in the ears, shortness of breath, tightness in the chest, numbness in the hands and feet, blurred or missing vision, palpitations. PMS: abdominal bloating, irritability, fights with close people, harsh scolding of children, changes in appetite, loss of confidence, blaming oneself, taking time off work, frequent tearfulness, wanting to die. Other: changes in food preferences (such as an obsession with certain foods), constipation, loose bowels (tendency to have diarrhea).

[0015]

[23] The composition according to any one of [1] to

[22] , which is a food or drink composition.

[24] The composition according to any one of [1] to

[22] , which is a pharmaceutical composition.

[0016]

[25] The composition according to [1], [2], [8], or

[17] , which is prepared so that the daily intake amount in terms of acetic acid is 700 mg or more.

[26] The composition according to [1], [2], [8], or

[17] , which is prepared so that the daily intake amount is 15 mL or more.

[27] The composition according to [1], [2], [8],

[17] ,

[25] , or

[26] , which is taken continuously for at least one menstrual cycle or for at least one month.

[0017]

[28] The composition according to [1], [2], [8], or

[17] , wherein the vinegar is fruit vinegar.

[29] The composition according to [1], [2], [8], or

[17] , wherein the vinegar is apple vinegar.

[30] The composition according to [1], [2], [8], or

[17] , wherein the vinegar is obtained by separately carrying out saccharification and ethanol fermentation, and / or separately carrying out ethanol fermentation and acetic acid fermentation, among the three processes of saccharification, ethanol fermentation, and acetic acid fermentation.

[31] The composition according to [1], [2], [8], or

[17] , wherein the vinegar has a free amino acid content of 5 to 2,000 ppm (mg / L) per 5 v / v% acidity.

[32] The composition according to [1], [2], [8], or

[17] , wherein the vinegar has a lactic acid content of 1,000 ppm (mg / L) or less per 5 v / v% acidity.

[33] The composition according to [1], [2], [8] or

[17] , wherein the content of malic acid in the vinegar per 5 v / v % of acetic acid is 100 ppm (mg / L) or more.

[0018]

[34] A composition for improving menstrual pain and / or menstrual symptoms in women in their twenties during menstruation, characterized by containing vinegar.

[35] The composition according to

[34] , wherein the menstrual symptoms category is negative emotions.

[36] The composition according to

[35] , wherein the item classified into the negative emotions category is "feeling depressed."

[0019]

[37] A composition for improving menstrual pain and / or menstrual symptoms in women in their 30s and 40s during menstruation, characterized by containing vinegar.

[38] The composition according to

[37] , wherein the menstrual symptoms are one or more of pain and water retention.

[39] The composition according to

[38] , wherein the item classified in the pain category is "lower back pain."

[40] The composition according to

[38] , wherein the item classified in the water retention category is "rough skin."

[0020]

[41] A composition for improving menstrual pain and / or menstrual symptoms in premenstrual women in their twenties, characterized by containing vinegar.

[42] The composition according to

[41] , wherein the menstrual symptom category is one or more of: decreased concentration, water retention, negative emotions, elevated mood, and others.

[43] The composition according to

[42] , wherein the item classified in the decreased concentration category is "decreased concentration."

[44] The composition according to

[42] , wherein the item classified in the water retention category is "swelling (abdomen, breasts, legs, etc.)."

[45] The composition according to

[42] , wherein the item classified in the negative emotions category is one or more of: "feeling like crying," "feeling anxious," and "feeling depressed."

[46] The composition according to

[42] , wherein the item classified in the elevated mood category is "becoming more open-minded."

[47] The composition according to

[42] , wherein the item classified into the other area is "changes in food preferences (e.g., becoming attached to a particular food)."

[0021]

[48] ​​A composition for improving menstrual pain and / or menstrual symptoms in premenstrual women in their 30s and 40s, characterized by containing vinegar.

[49] The composition according to

[48] , wherein the menstrual symptoms are one or more of behavioral changes, elevated mood, and PMS.

[50] The composition according to

[49] , wherein the item classified as behavioral changes is "decreased efficiency at work or study."

[0022]

[51] A composition for improving menstrual pain and / or menstrual symptoms in women in their twenties after menstruation, characterized by containing vinegar.

[52] The composition according to

[51] , wherein the category of menstrual symptoms is mood elevation.

[53] The composition according to

[52] , wherein the items classified into the category of mood elevation are one or more of "feeling happy" and "feeling gentle."

[0023]

[54] A composition for improving menstrual pain and / or menstrual symptoms in women in their 30s and 40s after menstruation, characterized by containing vinegar.

[0024]

[55] A method for improving menstrual pain and / or menstrual symptoms, comprising ingesting vinegar.

[56] The improving composition according to [1], used for improving menstrual pain and / or menstrual symptoms in women with generally regular menstrual cycles.

[57] The improving composition according to [1], used for improving menstrual pain and / or menstrual symptoms in women aged 20 to 45 who have generally regular menstrual cycles and who suffer from menstrual pain during menstruation.

[0025]

[58] A program that causes a computer to implement the following functions: acquiring menstrual cycle information of a user; estimating a menstrual stage from the menstrual cycle information; acquiring foods containing the menstrual symptom-improving composition and / or measures for alleviating menstrual symptoms corresponding to the menstrual symptoms specific to the menstrual stage based on a database storing the menstrual symptom-improving composition and recommended measures for alleviating menstrual symptoms according to claim 1; predicting an expected degree of menstrual symptom improvement using a trained model that receives input of foods containing the menstrual symptom-improving composition and / or measures for alleviating menstrual symptoms and outputs the expected degree of improvement; and outputting advice information regarding foods containing the menstrual symptom-improving composition and / or measures for alleviating menstrual symptoms based on the expected degree of improvement.

[59] The program according to

[58] , which suggests the advice information in advance about the foods and / or measures for alleviating menstrual symptoms that are expected to alleviate menstrual symptoms in the next and subsequent menstrual stages at an appropriate timing that satisfies predetermined conditions.

[60] The program according to

[58] , wherein the information about symptoms for each menstrual stage includes information about the user's symptoms for each menstrual stage.

[61] The program according to

[58] includes a function of acquiring attribute information related to the user's attributes, and the function of predicting the expected improvement level predicts the expected improvement level using a trained model that receives input of the attribute information in addition to the food containing the improving composition and / or the means for alleviating menstrual symptoms, and outputs the expected improvement level.

[62] The program according to

[61] , wherein the attribute information is one or more types selected from nationality, place of residence, address, gender recognized by the user, and occupation.

[63] The program according to

[61] , wherein the attribute information includes information about the timing of menarche.

[64] The program according to

[58] , wherein biometric information related to the user's body is acquired, and the acquired biometric information and the user's identification information are output to the information processing unit.

[65] The program according to

[64] , wherein the biometric information includes information about the severity of the user's menstrual symptoms.

[66] The program according to

[58] , which acquires eating information of a user and outputs the acquired eating information and the user's identification information to the information processing unit.

[67] The program according to

[66] , wherein the eating information is eating information estimated from the user's purchase history.

[68] The program according to

[58] , wherein the target users include pre-menarcheal users.

[69] The program according to

[58] , wherein the advice information is information regarding symptom relief in the future, one year or later.

[70] The program according to

[58] , wherein the advice information is information regarding symptom relief after menopause.

[0026]

[71] An information processing method executed by a computer, comprising the steps of: acquiring menstrual cycle information of a user; estimating a menstrual stage from the menstrual cycle information; acquiring foods containing the improving composition and / or means for alleviating menstrual symptoms corresponding to menstrual symptoms specific to the menstrual stage based on a database storing the improving composition described in [1] and recommended means for alleviating menstrual symptoms; predicting an expected degree of improvement using a trained model that receives input of foods containing the improving composition and / or means for alleviating menstrual symptoms and outputs the expected degree of improvement; and outputting advice information regarding foods containing the improving composition and / or means for alleviating menstrual symptoms based on the expected degree of improvement.

[0027] The composition of the present invention is effective in alleviating menstrual pain and menstrual symptoms before and after menstruation, as well as menstrual pain and menstrual symptoms during menstruation. Apple cider vinegar, in particular, has been used as a food product for many years, is highly safe, and can be taken over a long period of time. Furthermore, the composition of the present invention alleviates menstrual pain and menstrual symptoms, particularly by using acetic acid as an active ingredient. Furthermore, the composition of the present invention is expected to be even more effective by using vinegar that contains little components other than acetic acid (e.g., amino acids, lactic acid, minerals, etc.).

[0028] It is also possible to provide a program that outputs advice information regarding foods containing the improving composition and means for alleviating menstrual symptoms.

[0029] FIG. 1 is a diagram illustrating an evaluation schedule of the present invention. FIG. 2 is a graph of items with a significant difference at "5% significance" regarding the improvement effect during menstruation (all participants) of the present invention. FIG. 3 is a graph of items with a significant difference at "5% significance" regarding the improvement effect during menstruation (by age group) of the present invention. FIG. 4 is a graph of items with a significant difference at "5% significance" regarding the improvement effect before menstruation (all participants) of the present invention. FIG. 5 is a graph of items with a significant difference at "5% significance" regarding the improvement effect before menstruation (by age group) of the present invention. FIG. 6 is a graph of items with a significant difference at "5% significance" regarding the improvement effect after menstruation of the present invention. FIG. 7 is a schematic diagram showing an example of the configuration of an information processing system according to an embodiment of the program of the present invention. FIG. 8 is a block diagram showing an example of the configuration of a server of the information processing system according to an embodiment of the program of the present invention. FIG. 9 is a block diagram showing an example of the configuration of a user terminal of the information processing system according to an embodiment of the program of the present invention. FIG. 10 is a flowchart showing an example of the processing procedure of an embodiment of the program of the present invention.

[0030] The present invention will be described in detail below with reference to specific embodiments, but the present invention is not limited to the following embodiments and can be embodied in any form without departing from the spirit of the present invention.

[0031] As used herein, "premenstrual" refers to the period from 10 days before the onset of menstruation to the day before the onset of menstruation. "During menstruation" refers to the period from the first day to the third day of menstruation. "Postmenstrual" refers to the 10th day after menstruation.

[0032] In this specification, when multiple upper and / or lower limits are indicated for a numerical range, it is assumed that the numerical range defined by combining at least the maximum value of the upper limit and the minimum value of the lower limit is directly described, even if not otherwise specified. Furthermore, it is assumed that all numerical ranges obtained by combining any upper limit among the upper limits with any lower limit among the lower limits are included in one embodiment of the present invention.

[0033] In addition, in this specification, a numerical range connected with "to" means a numerical range that includes the numerical values ​​before and after "to" as the lower limit and upper limit. When multiple lower limit values ​​and multiple upper limit values ​​are separately indicated, any lower limit value and upper limit value can be selected and connected with "to".

[0034] As used herein, the terms "containing" and "comprise" encompass the concepts of "containing," "comprises," "consists essentially of," and "consists only of." When using the terms "containing" and "comprises," the listed steps or options do not necessarily have to be exhaustive.

[0035] In the present invention, the values ​​expressed as "mass %," "mass ppm," and "mass ppb" represent values ​​in "wet mass equivalent." "Wet mass equivalent" represents the content ratio of the target component in a sample, calculated using the wet mass of the sample including water as the denominator and the mass of the target component contained in the sample as the numerator. In the present invention, when "mass %" is used, it indicates the mass (g) of the target component contained in the sample per 100 g of sample, and can also be read as w / w%. Furthermore, mass ppm indicates the mass (mg) of the target component contained in 1 L of sample, and mass ppb indicates the mass (μg) of the target component contained in 1 L of sample.

[0036] [Vinegar] The active ingredient contained in the composition for alleviating menstrual pain and / or menstrual symptoms of the present invention (hereinafter simply referred to as the "composition of the present invention") is "vinegar." Examples of vinegar include brewed vinegar produced from grains such as rice or barley or fruit juice, and synthetic vinegars produced by adding seasonings such as sugar to glacial acetic acid or a diluted solution of acetic acid, or by adding brewed vinegar to glacial acetic acid or a diluted solution of acetic acid. Any brewed vinegar can be used in the present invention as long as it produces acetic acid through the action of microorganisms. Microorganisms that can be used are not particularly limited, but include acetic acid bacteria or lactic acid bacteria (e.g., bifidobacteria). More specifically, examples include vinegar (acetic acid) obtained by acetic acid fermentation using ethanol as a raw material using acetic acid bacteria, and acetic acid produced by decomposition of dietary fiber or sugars (e.g., polysaccharides, monosaccharides, oligosaccharides, fructose) using bifidobacteria.

[0037] The vinegar used in the present invention is not limited to brewed vinegar or synthetic vinegar, but may be any acetic acid that can be consumed as a food product, and the acetic acid may be used so as to satisfy the acetic acid content in the composition of the present invention, regardless of the raw material or production method. These vinegars may be used alone or in combination of two or more.

[0038] Brewed vinegars are liquid seasonings obtained by acetic acid fermentation using grains, fruits, vegetables, other agricultural products, honey, alcohol, and sugars as raw materials, and do not contain glacial acetic acid or acetic acid. Examples include grain vinegars (rice vinegar, black rice vinegar, brown rice vinegar, black vinegar, lees vinegar, malt vinegar, adlay vinegar, soybean vinegar, etc.), fruit vinegars (apple vinegar, grape vinegar, lemon vinegar, kabosu vinegar, plum vinegar, wine vinegar, balsamic vinegar, etc.), spirit vinegar, Chinese vinegar, sherry vinegar, etc.

[0039] On the other hand, examples of synthetic vinegar include glacial acetic acid or acetic acid diluted with water. Among these, fruit vinegars that have a mild flavor, a fruity aroma, a refreshing acidity and sweetness, and contain small amounts of other components (amino acids, lactic acid, minerals, etc.) are preferred, and apple vinegar is even more preferred, from the viewpoints of ease of ingestion (drinking), compatibility with other food ingredients (such as preventing flavor loss), and the efficient use of acetic acid as an active ingredient to achieve the effects of the present invention.

[0040] Brewed vinegar may be the brewed vinegar defined in the Japanese Agricultural Standards for Brewed Vinegar (last revised February 24, 2016, Ministry of Agriculture, Forestry and Fisheries Notification No. 489). Fruit vinegar may be brewed vinegar that uses one or more kinds of fruit as raw materials (limited to vinegar that does not use grains, agricultural products other than fruit, or honey) and the total amount used is 300 g or more of squeezed fruit juice per 1 L of brewed vinegar. Furthermore, apple vinegar may be fruit vinegar that uses 300 g or more of squeezed apple juice per 1 L of fruit vinegar.

[0041] The main component of the vinegar used in the composition of the present invention is acetic acid. However, if trace amounts of other organic acids such as gluconic acid, citric acid, and lactic acid are contained, all of these acids can be converted to acetic acid, and the proportion of acid in the vinegar can be expressed as acidity. The acidity of vinegar is not limited, but is preferably 4.0% (v / v%; hereinafter abbreviated as %) or more for brewed vinegar, 4.2% or more for grain vinegar, and 4.5% or more for fruit vinegar. Acidity can be measured according to the acidity measurement method described in Article 4 of the Japanese Agricultural Standards for Brewed Vinegar (last revised February 24, 2016, Ministry of Agriculture, Forestry and Fisheries Notification No. 489).

[0042] (Acetic Acid) The vinegar used in the composition of the present invention contains acetic acid as a main component. The acetic acid is mainly derived from vinegar. In the present invention, acetic acid refers to an acetic acid molecule (CH ３ COOH) and acetate ions (CH ３ COO-), and the acetic acid content refers to the total concentration of these.

[0043] (Acetic Acid Content) The content of acetic acid in the composition of the present invention is not particularly limited, but can be 0.03 to 20% by mass, further 0.05 to 10% by mass, further 0.1 to 5% by mass, further 0.5 to 4.5% by mass, or even 0.75 to 1% by mass. The lower limit of each of the above ranges can be 0.05 or more, 0.075 or more, 0.1 or more, 0.2 or more, 0.3 or more, 0.4 or more, 0.6 or more, 0.7 or more, or 0.73 or more. Furthermore, the upper limit of each of the above ranges can be 15 or less, 14 or less, 13 or less, 12 or less, 11 or less, 9 or less, 8 or less, 7 or less, 6 or less, 5.5 or less, 4.9 or less, 4.8 or less, 4.7 or less, 4.6 or less, 4.4 or less, 4.3 or less, 4 or less, 3.5 or less, 3 or less, 2.5 or less, 2 or less, 1.5 or less, 1.4 or less, 1.2 or less, or 1.1 or less. When the content of acetic acid is 0.03% by mass or more, a good effect of improving menstrual pain and menstrual symptoms can be obtained, and when it is 20% by mass or less, the flavor when ingested is good.

[0044] The content of acetic acid in vinegar is not particularly limited, but from the viewpoint of ease of ingestion of the composition of the present invention, it is preferably 35,000 ppm (mg / L) or more, more preferably 39,000 ppm (mg / L) or more, even more preferably 40,000 ppm (mg / L) or more, even more preferably 42,000 ppm (mg / L) or more, even more preferably 43,000 ppm (mg / L) or more, even more preferably 44,000 ppm (mg / L) or more, even more preferably 45,000 ppm (mg / L) or more, even more preferably 46,000 ppm (mg / L) or more, even more preferably 47,000 ppm (mg / L) or more, even more preferably 48,000 ppm (mg / L) or more, and even more preferably 49,000 ppm (mg / L) or more. If the acetic acid content in the vinegar is 50,000 ppm (mg / L) or more, when the vinegar is blended with the composition of the present invention, the acetic acid content can be ensured with a smaller amount of vinegar used.

[0045] The dissociation state of acetic acid varies depending on the pH of the solution, and it is said that the binding of dissociated protons to taste receptors causes a sour taste sensation. Therefore, it is important to adjust the amount of acetic acid and other ingredients added to the composition, taking into account the interaction between taste and aroma, the dissociation state of sour substances, and the pH of the beverage, which changes the sour taste sensation. The acetic acid content can be measured using high-performance liquid chromatography using the same measurement method as above.

[0046] (Free Amino Acids) The vinegar used in the composition of the present invention may contain free amino acids. Free amino acids may be in the L-, D-, or DL- configuration, and any of these may be used. Free amino acids are amino acids that exist alone in a free state in foods and beverages, separate from the amino acids that constitute proteins. Here, the term "free amino acids" refers to amino acids that exist alone in a free state in vinegar, and specifically refers to alanine, asparagine, cystine, glutamine, glycine, isoleucine, leucine, methionine, phenylalanine, proline, serine, threonine, tryptophan, tyrosine, valine, aspartic acid, glutamic acid, arginine, histidine, and lysine.

[0047] The free amino acid content per 5% acidity of vinegar is not particularly limited, but can be 5 to 2000 ppm (mg / L), 10 to 1000 ppm (mg / L), 15 to 800 ppm (mg / L), 20 to 500 ppm (mg / L), 20 to 300 ppm (mg / L), 20 to 200 ppm (mg / L), or 20 to 179 ppm (mg / L). The lower limits of each of the above ranges can be 6 or more, 8 or more, 12 or more, 14 or more, 16 or more, or 18 or more. The upper limits of each of the above ranges can be 900 or less, 800 or less, 700 or less, 600 or less, 550 or less, 450 or less, 400 or less, 350 or less, 250 or less, or 220 or less.

[0048] By maintaining the free amino acid content per 5% acidity in vinegar within the above range, the composition can be made easier to ingest from the viewpoint of flavor (taste and aroma), and the effects of the present invention can be more easily achieved using acetic acid as an active ingredient. However, if the content exceeds the above range, the refreshing sourness and sweetness of vinegar become less noticeable, and further, browning and changes in flavor are more likely to occur during storage of the composition of the present invention. Furthermore, the effects of the present invention using acetic acid as an active ingredient may be less easily achieved.

[0049] The free amino acid content can be measured using an automatic amino acid analyzer. Specifically, the analysis is performed using the following method. (1) The composition sample to be analyzed is subjected to pretreatment according to its properties. (2) If the composition sample is liquid, the composition sample is diluted with a solution of distilled water and lithium citrate buffer (pH 2.2) in equal parts, filtered through a 0.2 μm filter to remove coarse particles, and then subjected to analysis. (3) If the composition sample is solid or semi-solid, a certain amount of the composition sample is weighed out, appropriately diluted with distilled water, and suspended under sufficient stirring at room temperature. This suspension is filtered through No. 2 filter paper to obtain a filtrate. Thereafter, the sample is treated in the same manner as in the liquid form. (4) Using the composition sample that has undergone the above pretreatment, the free amino acid content is measured according to the amino acid analysis method described in the "Analysis Manual for the Standard Tables of Food Composition in Japan, 2015 Edition (7th Edition)." More specifically, the measurement may be carried out using an automatic amino acid analyzer (for example, "JLC-500 / V2 (manufactured by JEOL Ltd.)").

[0050] (Lactic Acid) The vinegar used in the composition of the present invention preferably contains lactic acid. It is known that organic acids such as acetic acid, lactic acid, and malic acid have different tastes depending on the type. It is known that when two or more substances with different tastes or aromas are mixed, interactions of tastes and aromas occur, such as a contrast effect in which one or both tastes or aromas are strengthened, a suppression effect in which one or both tastes or aromas are weakened, or a synergistic effect in which both tastes or aromas are further strengthened.

[0051] In order to balance the flavors of acetic acid and lactic acid in the composition of the present invention and to make it easier to ingest, the content of lactic acid per 5% acidity in vinegar is not particularly limited, but is preferably 1000 ppm (mg / L) or less, and the upper limit can be 900 ppm (mg / L) or less, 800 ppm (mg / L) or less, 700 ppm (mg / L) or less, 600 ppm (mg / L) or less, 500 ppm (mg / L) or less, 400 ppm (mg / L) or less, 300 ppm (mg / L) or less, 200 ppm (mg / L) or less, 100 ppm (mg / L) or less, 50 ppm (mg / L) or less, 40 ppm or less, 30 ppm or less, or 20 ppm or less. If the lactic acid content is within this range, the vinegar will have a favorable flavor, and even when mixed with other ingredients to form a composition, it is preferable because it does not upset the balance of the taste and aroma of the other ingredients.

[0052] Furthermore, from the viewpoint of making the astringent or bitter taste of the composition of the present invention less noticeable, and from the viewpoint of making acetic acid function more effectively as the effect of the present invention as an active ingredient, it is more preferable that the content of lactic acid per 5% acidity of vinegar be 200 ppm (mg / L) or less, even more preferably 100 ppm (mg / L) or less, even more preferably 50 ppm or less, even more preferably 40 ppm or less, even more preferably 30 ppm or less, and even more preferably 20 ppm or less.

[0053] (Malic Acid) The vinegar used in the composition of the present invention preferably contains malic acid. From the viewpoint of the flavor of the composition of the present invention, the content of malic acid per 5% acidity in the vinegar is not particularly limited, but is preferably 100 ppm (mg / L) or more. The lower limit can be 200 ppm (mg / L) or more, 300 ppm (mg / L) or more, 400 ppm (mg / L) or more, 500 ppm or more, 600 ppm or more, 700 ppm or more, 800 ppm or more, 900 ppm or more, or 1000 ppm or more. A content of 100 ppm (mg / L) or more is preferable because it provides a refreshing sour taste as vinegar and does not disrupt the balance of the taste and aroma of other ingredients even when mixed with other ingredients to form a composition.

[0054] Furthermore, from the viewpoint of making it easier to sense the refreshing sourness and pleasant aftertaste of the composition of the present invention, the content of lactic acid per 5% acidity of vinegar is more preferably 200 ppm (mg / L) or more, even more preferably 300 ppm (mg / L) or more, even more preferably 400 ppm or more, even more preferably 500 ppm or more, even more preferably 600 ppm or more, even more preferably 700 ppm or more, even more preferably 800 ppm or more, even more preferably 900 ppm or more, and even more preferably 1000 ppm or more.

[0055] The contents of lactic acid, malic acid, and acetic acid can all be measured using high performance liquid chromatography. <Measurement of the contents of lactic acid, malic acid, and acetic acid> Measurement may be performed using high performance liquid chromatography (HPLC) under the following conditions. <HPLC conditions> High performance liquid chromatography (manufactured by Shimadzu Corporation, model LC-10ADVP) Mobile phase (1) 4 mM p-toluenesulfonic acid aqueous solution, flow rate 0.9 mL / min Mobile phase (2) 16 mM Bis-Tris aqueous solution containing 4 mM p-toluenesulfonic acid and 80 μM EDTA, flow rate 0.9 mL / min Column: Shodex KC810P + KC-811 x 2 (manufactured by Resonac Corporation) Column temperature: 50°C Detection: UV 260 nm

[0056] (Method for Producing Vinegar) The method for producing the vinegar used in the composition of the present invention is not particularly limited, and it may be produced according to a method for producing ordinary vinegar. The ordinary method for producing vinegar (acetic acid fermentation method) can be broadly divided into surface fermentation (static fermentation method) and total fermentation (submerged fermentation method).

[0057] Surface fermentation (static fermentation) is a fermentation method in which acetic acid bacteria slowly convert ethanol into vinegar above the liquid surface in a fermenter without forcing air in. In static fermentation, the starting liquid added to the fermenter at the start of fermentation can be a mixture of ethanol (sometimes made by fermenting rice or grains with koji or enzymes, or fruit juice, and then fermenting the saccharified liquid or fruit juice with yeast to produce ethanol) and starter vinegar (a portion of the mash that has been fermented well).Other methods, such as the jar vinegar fermentation method used in the Fukuyama region of Kagoshima Prefecture, use a mixture of rice koji, steamed rice, water, and starter vinegar.

[0058] In the former method, the saccharification process, in which rice or grains are saccharified using koji or enzymes, the ethanol fermentation process, in which saccharified liquid or fruit juice is fermented to produce ethanol, and the acetic acid fermentation process, in which acetic acid bacteria convert ethanol into acetic acid, are all carried out separately.In other words, saccharification, ethanol fermentation, and acetic acid fermentation each proceed independently, and saccharification and ethanol fermentation do not occur simultaneously, nor do ethanol fermentation and acetic acid fermentation occur simultaneously.

[0059] On the other hand, with the latter method, the saccharification process, ethanol fermentation process, and acetic acid fermentation process all take place simultaneously in one fermentation tank (jar). In other words, starches such as steamed rice are saccharified by koji mold, and ethanol is produced by yeast present in the fermentation tank and in the air. At the same time that ethanol is produced, the ethanol is converted into acetic acid by acetic acid bacteria in the starter vinegar and those present in the fermentation tank. All of these processes take place simultaneously.

[0060] The most important thing to be careful of during static fermentation is contamination by microorganisms other than acetic acid bacteria (yeast, mold, lactic acid bacteria, etc.). If these microorganisms grow before the acetic acid bacteria begin to ferment vigorously, they not only inhibit the fermentation by the acetic acid bacteria, but also cause the fermentation liquid to become cloudy and produce off-flavors and odors (unpleasant flavors). To prevent this, it is important to add starter vinegar to the brewing liquid to provide an appropriate acidity, maintain a low pH, suppress the growth of other microorganisms, and promptly initiate fermentation by acetic acid bacteria, thereby increasing the acidity of the fermentation liquid itself.

[0061] On the other hand, in the latter fermentation method, saccharification, ethanol fermentation, and acetic acid fermentation proceed simultaneously and in parallel, so that sufficient acidity is not ensured in the fermentation broth, and since saccharification and ethanol fermentation other than acetic acid fermentation also proceed in parallel, a sufficient amount of acetic acid (acidity) cannot be ensured, and microorganisms other than acetic acid bacteria are likely to grow, making the resulting vinegar more likely to become cloudy or have an unpleasant taste (off-flavor or odor), and also making it more likely that components other than acetic acid (lactic acid, etc.) are produced in the vinegar. For these reasons, in order to improve the flavor and intake of the composition of the present invention, and further from the perspective of using acetic acid as an active ingredient rather than other components to more effectively utilize the effects of the present invention, it is preferable to use vinegar obtained by a fermentation method in which saccharification, ethanol fermentation, and acetic acid fermentation are each carried out separately, rather than by simultaneously proceeding saccharification and ethanol fermentation, or ethanol fermentation and acetic acid fermentation.

[0062] (Total Fermentation Method) The total fermentation method (submerged fermentation method) is a fermentation method in which saccharification, ethanol fermentation, and acetic acid fermentation are carried out completely separately, and furthermore, air is forcibly supplied to convert ethanol to acetic acid by acetic acid bacteria in a very short period of time. Therefore, a sufficient amount of acetic acid can be more quickly secured to prevent the growth of other microorganisms, and vinegar with very little unpleasant flavor (off-flavor, off-odor) can be obtained, which is preferable from the viewpoint of ease of ingestion as the composition of the present invention. Furthermore, since it is a fermentation method in which ethanol is converted to acetic acid by acetic acid bacteria in a very short period of time, the acetic acid produced can prevent the growth of other microorganisms, so components other than acetic acid (such as lactic acid) are less likely to be produced during fermentation, and it is also preferable from the viewpoint of obtaining a vinegar (composition) that more effectively exhibits the effects of the present invention using acetic acid as an active ingredient.

[0063] These vinegars may be used alone or in combination of two or more. The content of vinegar in the composition of the present invention is not limited, but may be adjusted according to the acetic acid content and pH described below.

[0064] (pH) The pH of the composition of the present invention may be any acidic value (less than pH 7), and is not particularly limited. It is usually determined from the perspective of the overall balance of flavor, and is not particularly limited, but can be, for example, in the range of 4 to 6. Specifically, the lower limit is usually 4 or more, but is preferably 4.1 or more, 4.2 or more, 4.3 or more, 4.4 or more, 4.5 or more, or 4.6 or more. On the other hand, the upper limit is not limited, but can be 6 or less, 5.9% or less, 5.8 or less, 5.7 or less, 5.6 or less, or 5.5 or less. The pH may be measured at room temperature (20°C) using a pH meter manufactured by HORIBA or the like.

[0065] (Other Components) As long as the composition of the present invention contains vinegar (acetic acid), it may contain, as appropriate, fruit juice, flavoring ingredients (bonito stock, kelp stock, bonito extract, kelp extract, seafood extract, fruit juice, vegetable juice, etc.), umami seasonings (soy sauce, fish sauce, protein hydrolysate, yeast extract, etc.), emulsifiers, thickeners, vegetables (garlic, ginger, onion, etc.) or vegetable extracts, alcohol or alcoholic beverages, stabilizers, coloring agents, additives such as calcium salts, amino acid-based seasonings, nucleic acid-based seasonings, organic acid-based seasonings, acidulants, flavoring ingredients, spices, oils and fats, water, etc.

[0066] In addition to the above ingredients, ingredients and fillings used in ordinary foods for seasoning, etc., can be added to the extent that the effects are not impaired. For example, ingredients (seasoning ingredients) for seasoning, etc., can include water, sugars (including high-intensity sweeteners), salt, oils and fats, vinegar, fruit juice, spices, spice extracts, flavor oils, amino acid seasonings, nucleic acid seasonings, organic acid seasonings, flavor ingredients, umami seasonings, alcoholic beverages, flavors, and other taste and flavor components, as well as additives such as gums and viscosity modifiers other than cold water swelling starch, stabilizers, colorants, and calcium salts. In addition to these seasoning ingredients, ingredients such as vegetables (carrots, burdock, radish, etc.), fruits, fruit peels, grains (red beans, soybeans, etc.), meat, and fish can also be added. The content of these seasoning ingredients and fillings is not particularly limited and can be determined appropriately depending on the intended use of the composition.

[0067] (Fats and Oils) Examples of fats and oils include soybean oil, soybean germ oil, rapeseed oil, corn oil, sesame oil, perilla oil, linseed oil, peanut oil, safflower oil, high oleic acid safflower oil, sunflower oil, cottonseed oil, grape seed oil, macadamia nut oil, hazelnut oil, pumpkin seed oil, walnut oil, camellia oil, tea seed oil, perilla oil, olive oil, rice bran oil, wheat germ oil, palm oil, algae oil, etc. These fats and oils may be used alone or in any combination or ratio of two or more.

[0068] (Sugars) Examples of sugars include sugar, maltose, fructose, isomerized liquid sugar, glucose, starch syrup, dextrin, and sugar alcohols such as sorbitol, maltitol, and xylitol. These sugars may be used alone, or two or more may be used in any combination or in any ratio. Examples of high-intensity sweeteners include aspartame, acesulfame potassium, sucralose, neotame, licorice extract, stevia, and enzyme-treated products thereof. These high-intensity sweeteners may be used alone, or two or more may be used in any combination or in any ratio.

[0069] (Salt) Salt itself may be used, or a food containing salt may also be used. The food containing salt is not particularly limited, but examples thereof include soy sauce, miso, and dashi. The soy sauce is not particularly limited, but examples thereof include dark soy sauce, light soy sauce, white soy sauce, tamari soy sauce, and re-brewed soy sauce. These soy sauces may be used alone, or two or more may be used in any combination and ratio.

[0070] (Miso) Miso is not particularly limited, but examples include barley miso, rice miso, soybean miso, blended miso, and red miso, white miso, light-colored miso, etc., which are named according to the difference in color resulting from their manufacturing method. These miso may be used alone or in any combination or ratio of two or more types.

[0071] (Spices) Spices refer to parts of plants (such as fruit, peel, flower, bud, bark, stem, leaf, seed, root, or rhizome) that have a unique aroma, pungent taste, and color and are incorporated into foods and beverages for the purposes of flavoring, deodorizing, seasoning, coloring, etc., and include spices and herbs. Spices refer to spices whose usable parts are excluding the stem, leaf, and flower, and examples include pepper (black pepper, white pepper, red pepper), garlic, ginger, sesame (sesame seeds), chili pepper, horseradish (horseradish), mustard, poppy seeds, yuzu, nutmeg, cinnamon, paprika, cardamom, cumin, saffron, allspice, cloves, Japanese pepper, orange peel, fennel, licorice, fenugreek, dill seeds, Japanese pepper, long pepper, and olive fruit. Herbs refer to spices that use the stems, leaves, and flowers, and examples include watercress, coriander, shiso, celery, tarragon, chives, chervil, sage, thyme, laurel, chives, parsley, mustard greens (mustard), myoga, mugwort, basil, oregano, rosemary, peppermint, savory, lemongrass, dill, wasabi leaves, and Japanese pepper leaves.

[0072] (Spice Extract) The spice extract may be any extract of a food generally labeled as a "spice" or "spices," and examples thereof include chili pepper extract, mustard extract, ginger extract, wasabi extract, pepper extract, garlic extract, onion extract, Japanese pepper extract, etc. These spice extracts may be used alone, or two or more may be used in any combination or in any ratio.

[0073] Examples of the flavor oils include ginger oil, garlic oil, mustard oil, onion oil, sesame oil, green onion oil, chive oil, parsley oil, perilla oil, wasabi oil, lemon oil, seafood oil, and meat oil. These flavor oils may be used alone or in any combination or ratio of two or more.

[0074] (Amino Acid Seasonings) Examples of amino acid seasonings include L-sodium glutamate, DL-alanine, glycine, L- or DL-tryptophan, L-phenylalanine, L- or DL-methionine, L-lysine, L-aspartic acid, L-sodium aspartate, L-arginine, etc. These amino acid seasonings may be used alone or in any combination of two or more in any ratio.

[0075] (Nucleic Acid-Based Seasonings) Examples of nucleic acid-based seasonings include 5-inosinate disodium, 5-guanylate disodium, 5-uridylate disodium, 5-cytidylate disodium, 5-ribonucleotide calcium, 5-ribonucleotide disodium, etc. These nucleic acid-based seasonings may be used alone or in any combination or ratio of two or more.

[0076] (Organic Acid Seasonings) Examples of organic acid seasonings include calcium citrate, trisodium citrate, potassium gluconate, sodium gluconate, succinic acid, monosodium succinate, disodium succinate, sodium acetate, potassium DL-hydrogen tartrate, potassium L-hydrogen tartrate, sodium DL-tartrate, sodium L-tartrate, potassium lactate, calcium lactate, sodium lactate, monosodium fumarate, and sodium DL-malate. These organic acid seasonings may be used alone, or two or more may be used in any combination or in any ratio. Using two or more organic acid seasonings in combination is preferred because the tastes of both seasonings are synergistically enhanced.

[0077] (Flavoring ingredients) Examples of flavoring ingredients include bonito stock, kelp stock, vegetable extract, bonito extract, kelp extract, seafood extract, meat extract, etc. These flavoring ingredients may be used alone or in any combination or ratio of two or more.

[0078] (Umami seasoning) Examples of umami seasonings include protein hydrolysates, yeast extracts, etc. These umami seasonings may be used alone or in any combination or ratio of two or more.

[0079] (Alcoholic Beverages) Examples of alcoholic beverages include sake, synthetic sake, mirin, shochu, wine, liqueur, Shaoxing wine, etc. These alcoholic beverages may be used alone or in any combination or ratio of two or more.

[0080] (Flavor) Examples of flavors include ginger flavor, garlic flavor, mustard flavor, onion flavor, sesame flavor, green onion flavor, chive flavor, shiso flavor, wasabi flavor, lemon flavor, etc. These flavors may be used alone or in any combination or ratio of two or more.

[0081] (Viscosity Adjusting Agent) Examples of viscosity adjusting agents include alginic acid, sodium alginate, carrageenan, karaya gum, agar, cellulose, tamarind seed gum, pullulan, pectin, chitin, chitosan, etc. These viscosity adjusting agents may be used alone or in any combination or ratio of two or more.

[0082] <Form of Composition> The composition of the present invention can be widely used because the active ingredient is derived from a natural product and is easy to produce, and can be provided alone or as an additive to various foods and beverages such as beverages, seasonings, confectioneries, foods, functional foods, supplements, fish paste products, processed meat products, processed dairy products, processed vegetable products, processed fruit products, oily foods, luxury foods, frozen foods, retort foods, canned foods, bottled foods, instant foods, pharmaceuticals, quasi-drugs, and even feed, etc. The form of the composition is not particularly limited as long as it contains vinegar (acetic acid), and examples thereof include liquid beverages, liquid seasonings, liquid compositions, jelly compositions, soft capsules, dried solids, and powdered compositions.

[0083] <Method of Ingestion> The method of use and dosage of the composition of the present invention are not particularly limited, but it can be ingested, for example, by the following method.

[0084] (Usage) As the main ingredient is vinegar (acetic acid), it can be taken every day, and it may be taken once or multiple times per day.

[0085] (Dosage) The dosage (amount of intake) can be such that the composition can be taken at a level that does not harm health, and from the viewpoint of achieving the effect of improving menstrual pain and menstrual symptoms, for example, the amount of acetic acid taken by an adult woman per day is 700 mg or more, preferably 720 mg or more, more preferably 730 mg or more, even more preferably 735 mg or more, still more preferably 740 mg or more, and even more preferably 750 mg or more.

[0086] For example, if the composition of the present invention is a liquid apple vinegar composition containing acetic acid at a concentration of 50,000 mg / 100 g, the daily intake of the composition (apple vinegar) should be 14 g or more (700 mg of acetic acid). Alternatively, if the composition is a vinegar drink containing fruit juice and the vinegar drink contains acetic acid at a concentration of 200 mg / 100 g, the daily intake of the composition should be 350 g or more (700 mg of acetic acid). When eating or drinking the composition, the composition may be ingested as is, or may be mixed or diluted with water or other food ingredients. In either case, the daily intake of acetic acid obtained by ingesting the composition should be within the above-mentioned range.

[0087] If the daily intake of acetic acid is within the above-described range, an effect of improving menstrual pain and menstrual symptoms can be obtained. The intake amount of the composition is not particularly limited, but from the viewpoint of reducing the volume of the composition itself and making it easy to take, the daily intake amount of the composition can be set to 1 to 1000 g, preferably 5 to 750 g, more preferably 10 to 600 g, even more preferably 15 to 500 g, 20 to 300 g, 30 to 200 g, 50 to 150 g, or 60 to 100 g. The lower limit of each of the above ranges can be 2 g or more, 3 g or more, 4 g or more, 6 g or more, 7 g or more, 8 g or more, 9 g or more, 11 g or more, 12 g or more, 13 g or more, 14 g or more, 16 g or more, 17 g or more, 18 g or more, 19 g or more, 25 g or more, 35 g or more, 40 g or more, 45 g or more, or 55 g or more. The upper limit of each of the above ranges can be 900 g or less, 800 g or less, 650 g or less, 550 mg or less, 450 g or less, 400 g or less, 350 g or less, 340 g or less, 330 g or less, 320 g or less, 310 g or less, or 250 g or less.

[0088] In the present invention, the daily intake of acetic acid may satisfy the above-mentioned requirement, but it may also be the daily intake of acetic acid converted into that of an adult female weighing 50 kg that satisfies the above-mentioned requirement. In the present invention, the term "adult female" refers to a female with a generally regular menstrual cycle, and more specifically, may be a female aged 20 to 45.

[0089] That is, the present invention is not directed to improving abnormalities in the menstrual cycle due to irregular menstruation associated with polycystic ovary syndrome (PCOS) or the like, but is directed to improving (alleviating symptoms of) menstrual pain and / or menstrual symptoms in users who are already menstruating, and is an invention with a completely different mechanism. In particular, by continuously improving daily dietary habits with an eye to the future, including one year from now and even the future after menopause, future symptom alleviation can be expected without relying on pharmaceutical treatment or the like.

[0090] The present invention will be described below with reference to examples, but the present invention is not limited to these examples in any way.

[0091] [Test Example] Subjects were asked to ingest the test diet under the following conditions, and the improvement in menstrual pain and menstrual symptoms was evaluated using VAS and MDQ scores.

[0092] 1. Subjects The subjects were 22 women aged 20 to 45 who had generally regular menstrual cycles and suffered from menstrual pain (lower abdominal and lower back pain) during menstruation. They were divided into Group A (11 women) and Group B (11 women). The age distribution is as follows: In this specification, "all" refers to women aged 20 to 44, "in their 20s" refers to women aged 20 to 29, and "in their 30s to 40s" refers to women aged 30 to 44. (20s) (30s) (40s) Total Group A 7 3 1 11 Group B 8 2 1 11 Total 15 5 2 22

[0093] 2. Test Food and Intake Method (Test Food) Vinegar (apple vinegar manufactured by Mizkan Co., Ltd.) with an acidity of 5% and an acetic acid content of 49,000 ppm (mg / L) was used.

[0094] The apple cider vinegar used in this test had a free amino acid content of 179 ppm per 5% acidity of vinegar. This is because it is easier to ingest from the standpoint of flavor (taste and aroma) compared to black vinegar, which has a balanced amino acid content and a high amino acid content (specifically, black vinegar produced by static fermentation, which successively performs the steps of saccharification, alcoholic fermentation, acetic acid fermentation, and aging from starchy raw materials, has a free amino acid content of 2000 ppm or more per 5% acidity of vinegar), making it suitable for use in the present invention.

[0095] The apple cider vinegar used in this test had a lactic acid content of 20 ppm per 5% acidity of the vinegar. This means that compared to black vinegar, which has a high lactic acid content and is made using koji with lactic acid bacteria attached and utilizing the lactic acid produced by the lactic acid bacteria to prevent microbial contamination (specifically, black vinegar produced by static fermentation, which successively carries out the steps of saccharification, alcoholic fermentation, acetic acid fermentation, and aging from a starchy raw material, has a lactic acid content of 1,000 ppm or more per 5% acidity of the vinegar), the flavor is more balanced, there is less of an astringent or bitter taste, and it is easier to consume, making it suitable for use in the present invention.

[0096] Furthermore, the apple cider vinegar used in this test had a malic acid content of 1000 ppm per 5% acidity of the vinegar. This means that compared to black vinegar, which uses grain as the raw material and therefore contains almost no malic acid (specifically, vinegar produced by static fermentation, which successively performs the steps of saccharification, alcoholic fermentation, acetic acid fermentation, and aging from starchy raw materials, has a malic acid content of 0 ppm per 5% acidity of the vinegar), it does not disrupt the balance of the taste and aroma of the other raw materials and makes it easier to feel a refreshing acidity and a pleasant aftertaste, making it suitable for use in the present invention.

[0097] The acidity and acetic acid content were measured by the above-mentioned methods. Since the specific gravity of vinegar is 1.02, the acetic acid content is 4.80% by mass.

[0098] (Method of Ingestion) Once daily, 15 mL of the test food (equivalent to 735 mg of acetic acid) was placed in a measuring cup, diluted with water to 100 mL, and ingested upon waking or with breakfast.

[0099] (Intake Period) A crossover test was conducted on Group A and Group B subjects over four menstrual cycles (approximately 16 weeks) as shown in Figure 1. Group A: The test food was taken during the first two menstrual cycles (menstrual cycles 1 and 2), and not during the last two menstrual cycles (menstrual cycles 3 and 4). Group B: The test food was not taken during the first two menstrual cycles (menstrual cycles 1 and 2), and was taken during the last two menstrual cycles (menstrual cycles 3 and 4).

[0100] 3. Evaluation Items <Menstrual pain> Menstrual pain was evaluated using the VAS (Visual Analogue Scale) method and the MDQ (Menstrual Distress Questionnaire) method. In the VAS method, menstrual pain was evaluated as the evaluation item, and in the MDQ method, the two items "lower abdominal pain" and "lower back pain" (corresponding to No. 1 and No. 2 in Table 1, respectively) in the "pain" domain of the 56 items shown in Table 1 of menstrual symptoms below were defined as menstrual pain and evaluated.

[0101] The VAS method was performed by having the subject mark where on a 10cm straight line the pain of menstrual cramps they felt was located, with one end of the line marked "no pain (0)" and the other end marked "the worst pain imaginable (100)." For example, if the left end of the line is marked "no pain (0)" and the right end is marked "the worst pain imaginable (100)," and the subject marks 3.2 cm from the left end, the pain score would be 32.

[0102] <Menstrual symptoms> Menstrual symptoms were evaluated using the MDQ method on 56 items in 10 domains shown in Table 1. These 56 items consist of 54 items, consisting of 47 items from the MDQ, which is used as a scale for measuring menstrual symptoms related to both the physical and mental aspects of the menstrual cycle, plus 7 items from PMS, which is a scale for evaluating mood (see "Study on menstrual symptoms in adolescent girls using MDQ scores: Showa Medical Society Journal, Vol. 68, No. 3, 2008, pp. 155-161"), plus 2 items (constipation and loose bowels (slight diarrhea)) that were added separately for this study.

[0103] These 56 items were divided into 10 categories (pain, decreased concentration, behavioral changes, autonomic imbalance, water retention, negative emotions, elevated mood, control, other, PMS) for each category. Two additional categories added in this study (constipation and loose bowels (slight diarrhea)) were classified into the other category.

[0104] The evaluation method for each item in the MDQ method was to rate it on a four-point scale: "none: 0", "weak: 1", "medium: 2", and "strong: 3".

[0105]

[0106] 4. Evaluation Schedule As shown in Figure 1, evaluation of menstrual pain and menstrual symptoms was performed using the VAS and MDQ methods according to the following schedule. (1) to (13) in the figure all indicate the days on which the subject performed the evaluation, and the intended timing of measurement and the evaluation period are as follows: (Evaluation date symbols: ●○☆) ●: Postmenstrual: On the 10th day after the start of menstruation, symptoms on that day were recorded. 〇: Premenstrual: On the 1st day after the start of menstruation, symptoms from the 10th day before the start of menstruation to the day before the start of menstruation were recorded. ☆: During menstruation: On the 4th day after the start of menstruation, symptoms from the 1st to 3rd days after the start of menstruation were recorded.

[0107] (1) in Figure 1 is the point at which the reference value before ingesting the test meal is measured (hereinafter also referred to as "baseline"), and is specifically as follows: (1) x: Evaluation date of reference menstruation (baseline). On the day after the end of "menstruation-1", postmenstrual symptoms (normal postmenstrual period), premenstrual symptoms (symptoms from 10 days before the start of menstruation-1 to the day before the start), and menstrual symptoms (days 1 to 3 from the start of menstruation-1) were evaluated together.

[0108] (2) to (13) shown in Figure 1 are the points at which the effects of the test food were measured after the initiation of intake, and are specifically as follows: (2) ●: On the 10th day from the start of "-1st menstruation," symptoms on that day (corresponding to postmenstrual symptoms) were evaluated. (3) ○: On the 1st day from the start of "1st menstruation," symptoms from the 10th day before the start of "1st menstruation" to the day before the start of menstruation (corresponding to premenstrual symptoms) were evaluated. (4) ☆: On the 4th day from the start of "1st menstruation," symptoms from the 1st to 3rd days of "1st menstruation" (corresponding to symptoms during menstruation) were evaluated. Thereafter, (5) to (13) correspond to "2nd menstruation," "3rd menstruation," and "4th menstruation," and the evaluation was repeated using the same content as (2) to (4) above.

[0109] The terms used in this test are defined as follows: "Menstrual cycle" refers to the period from the day after the end of menstruation to the day the next menstruation ends. As shown in Figure 1, "menstrual cycle 1" refers to the period from the day after the end of "menstruation-1" to the day after the end of "menstruation-1", "menstrual cycle 2" refers to the period from the day after the end of "menstruation-1" to the day after the end of "menstruation-2", "menstrual cycle 3" refers to the period from the day after the end of "menstruation-2" to the day after the end of "menstruation-3", and "menstrual cycle 4" refers to the period from the day after the end of "menstruation-3" to the day after the end of "menstruation-4". The test period is the four menstrual cycles, "menstrual cycle 1" to "menstrual cycle 4".

[0110] Furthermore, "reference menstruation" refers to the menstruation immediately before starting to take the test food (menstruation - 1 in Figure 1), and the test results during the period of "menstrual cycle 0" including the "reference menstruation" were defined as the "baseline," which was used as control data.

[0111] Furthermore, "test meal intake (first time)" refers to the test results in "menstrual cycle 1" for Group A and "menstrual cycle 3" for Group B, out of the four menstrual cycles during the test period. Similarly, "test meal intake (second time)" refers to the test results in "menstrual cycle 2" for Group A and "menstrual cycle 4" for Group B. On the other hand, "no test meal intake (first time)" refers to the test results in "menstrual cycle 3" for Group A and "menstrual cycle 1" for Group B, out of the four menstrual cycles during the test period. Similarly, "no test meal intake (second time)" refers to the test results in "menstrual cycle 4" for Group A and "menstrual cycle 2" for Group B.

[0112] "5% significant" means a p-value of less than 0.05 (p<0.05) compared to the baseline in a multiple comparison test. The multiple comparison test used the Holm method for VAS evaluation results and the Scheffe method for MDQ evaluation results.

[0113] 3. Evaluation Results The following examples show statistically significant improvements in menstrual pain and menstrual symptoms. The evaluation results for each subject who showed improvement at a 5% significance level are shown in Figures 2 to 7.

[0114] Example 1: Changes in menstrual pain and menstrual symptoms during menstruation (all subjects) The evaluation results during menstruation are shown in Table 2 and Figure 2. For all subjects (22 subjects), improvements were observed in menstrual pain and menstrual symptoms during menstruation using both the VAS method and the MDQ method. Specifically, the results are as follows:

[0115] In the VAS method, the mean values ​​were significantly reduced compared to the baseline both with and without the test meal (first and second times), demonstrating an improvement in menstrual pain.

[0116] In the MDQ method, when the sum of the average values ​​of all 56 items was used as the standard, the average values ​​significantly decreased compared to baseline for both the test meal intake (first time) and test meal intake (second time), demonstrating an improvement in menstrual pain and menstrual symptoms. Furthermore, when the sum of the average values ​​of the PMS domain (all 7 items) was used as the standard, the average value significantly decreased compared to baseline for the test meal intake (second time), demonstrating an improvement in menstrual symptoms. Furthermore, the average values ​​for "lower back pain" and "easy fatigue" in the pain domain significantly decreased compared to baseline for either the test meal intake (first time) or test meal intake (second time), demonstrating an improvement in menstrual pain and menstrual symptoms. Furthermore, the average value for "feeling depressed" in the negative emotion domain significantly decreased compared to baseline for both the test meal intake (first time) and test meal intake (second time), demonstrating an improvement in menstrual pain and menstrual symptoms.

[0117] Example 2: Changes in menstrual pain and menstrual symptoms during menstruation (in women in their 20s) The evaluation results during menstruation are shown in Table 2 and Figure 3. Improvement effects were observed in 15 subjects in their 20s regarding menstrual pain and menstrual symptoms during menstruation, using both the VAS method and the MDQ method. Specifically, the results are as follows:

[0118] In the VAS method, the mean values ​​were significantly reduced compared to the baseline both with and without the test meal (first and second times), demonstrating an improvement in menstrual pain.

[0119] In the MDQ method, when the sum of the average values ​​of all 56 items was used as the standard, the average value significantly decreased compared to the baseline when the test meal was ingested (first time), and an improvement effect was observed in menstrual pain and menstrual symptoms.

[0120] Example 3: Changes in menstrual pain and menstrual symptoms during menstruation (30s and 40s) The evaluation results during menstruation are shown in Table 2 and Figure 3. Improvement effects were observed in the menstrual pain and menstrual symptoms during menstruation for seven subjects in their 30s and 40s using the MDQ method. Specifically, the results are as follows:

[0121] In the MDQ method, the mean values ​​for "lower back pain" in the pain area and "rough skin" in the water retention area were significantly reduced compared to baseline after test meal intake (second time), and improvements in menstrual pain and menstrual symptoms were observed.

[0122]

[0123] Example 4: Changes in premenstrual pain and menstrual symptoms (all subjects) The premenstrual evaluation results are shown in Table 3 and Figures 4 and 5. For 22 subjects, improvements were observed in premenstrual pain and menstrual symptoms using the MDQ method. Specifically, the results are as follows:

[0124] In the MDQ method, when the sum of the mean values ​​of the water retention domain (4 items in total) and PMS domain (7 items in total) was used as the standard, the mean values ​​significantly decreased from baseline in both the first and second sessions of test meal intake, demonstrating an improvement in menstrual symptoms.Furthermore, when the sum of the mean values ​​of the autonomic nervous system imbalance domain (4 items in total) and negative emotion domain (8 items in total) was used as the standard, the mean values ​​significantly decreased from baseline in either the first or second session of test meal intake, demonstrating an improvement in menstrual symptoms. In addition, the mean values ​​of "easily tired" in the pain domain of the MDQ method, "hot face" in the autonomic imbalance domain, "rough skin", "swelling (abdomen, breasts, legs, etc.)", and "weight gain" in the water retention domain, "feel like crying", "feel anxious", "feel lonely", and "feel depressed" in the negative emotion domain, and "constipation" in the other domain were significantly reduced from baseline either with or without the test meal intake (first time), and an improvement in menstrual pain and menstrual symptoms was observed.

[0125] Example 5: Changes in menstrual pain and menstrual symptoms before menstruation (in women in their 20s) The evaluation results before menstruation are shown in Table 3 and Figure 6. For 15 subjects in their 20s, an improvement effect was observed in menstrual symptoms during menstruation using the MDQ method. Specifically, the results are as follows.

[0126] In the MDQ method, when the sum of the average values ​​of each area in the water retention area (all 4 items) was used as the standard, the average value significantly decreased from baseline in both the first and second test meal intakes, demonstrating an improvement in menstrual symptoms. Furthermore, when the sum of the average values ​​of each area in the negative emotion area (all 8 items) was used as the standard, the average value significantly decreased from baseline in the first test meal intake, demonstrating an improvement in menstrual symptoms. Furthermore, the average values ​​for "decreased concentration" in the concentration decline area, "feeling like crying" and "feeling anxious" in the negative emotion area, and "becoming obedient" in the mood elevation area in the MDQ method were significantly decreased from baseline in either the first test meal intake or the second test meal intake, demonstrating an improvement in menstrual symptoms.

[0127] Example 6: Changes in premenstrual pain and menstrual symptoms (30s and 40s) The premenstrual evaluation results are shown in Table 3 and Figure 6. Improvement effects were observed in premenstrual pain and menstrual symptoms using the MDQ method for seven subjects in their 30s and 40s. Specifically, the results are as follows:

[0128] In the MDQ method, when the sum of the average values ​​of all 56 items was used as the standard, the average value significantly decreased compared to baseline after taking the test meal (2nd time), and an improvement effect was observed in menstrual pain and menstrual symptoms.In addition, when the sum of the average values ​​of each area in the mood elevation domain (all 5 items) was used as the standard, the average value significantly decreased compared to baseline after taking the test meal (2nd time), and an improvement effect was observed in menstrual symptoms.

[0129]

[0130] Example 7: Changes in menstrual pain and menstrual symptoms after menstruation (all subjects) The evaluation results after menstruation are shown in Table 4 and Figure 7. For 22 subjects, an improvement effect was observed in menstrual symptoms after menstruation using the MDQ method. Specifically, the results are as follows:

[0131] The mean value of "feeling depressed" in the negative emotion domain of the MDQ method significantly decreased compared to the baseline after the test meal was taken (second time), and an improvement in menstrual symptoms was observed.

[0132] Example 8: Changes in menstrual pain and menstrual symptoms after menstruation (in women in their 20s) The results of the postmenstrual evaluation are shown in Table 4 and Figure 7. For 15 subjects in their 20s, an improvement in menstrual symptoms after menstruation was observed using the MDQ method. Specifically, the results are as follows:

[0133] In the MDQ method, the mean value of "feeling gentle" in the mood elevation domain significantly decreased compared to baseline when the test meal was ingested (first time), and an improvement in menstrual symptoms was observed.

[0134]

[0135] <Example 9> Data for all items for all participants, those in their 20s, and those in their 30s and 40s during menstruation, premenstruation, and postmenstruation are shown in Tables 5 to 13. In each table, in the same multiple comparison test as above, items with a p-value of less than 0.05 (p<0.05) and a "5% significance" are marked with "*", and items with a p-value of more than 0.05 but less than 0.1 (0.05≦p<0.1) and a "10% trend" are marked with "★". In addition, for those who took the test meal, the reduction rate of the score for "with test meal ingestion (second time)" relative to the score for "with test meal ingestion (first time)" was calculated using the following formula and is shown in the tables. <Calculation formula for reduction rate> Reduction rate [%] = (average value of "with test meal ingestion (first time)" - average value of "with test meal ingestion (second time)") / average value of "with test meal ingestion (first time)" × 100

[0136] The results obtained from Tables 5 to 13 are discussed below.

[0137] <Changes in menstrual pain and menstrual symptoms during menstruation (all subjects)> The results are shown in Table 5. That is, during "menstruation", in the item "menstrual pain", the VAS method showed a significant effect of decreasing the mean value from baseline in the "test food intake (first time)" category (5% significant difference). That is, an improvement effect of acetic acid intake on menstrual pain is observed. That is, during "menstruation", in the item "menstrual pain", the VAS method showed a significant effect of decreasing the mean value from baseline in the "test food intake (second time)" category (5% significant difference). That is, an improvement effect of acetic acid intake on menstrual pain is observed. That is, during "menstruation", in the item "menstrual pain", the VAS method showed a greater effect of decreasing the mean value from baseline in the "test food intake (second time)" category than in the "test food intake (first time)" category (reduction rate 21.2%). Therefore, it was found that when a predetermined amount of acetic acid per day (for example, 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect in the category of "menstrual pain" is enhanced by continued intake. That is, in the category of "menstrual pain (change)" during "menstruation", the VAS method showed a significant decrease in the mean value compared to the baseline for "test food intake (first time)" (5% significant difference). That is, an improvement effect of acetic acid intake on menstrual pain is confirmed. That is, in the category of "menstrual pain (change)" during "menstruation", the VAS method showed a significant decrease in the mean value compared to the baseline for "test food intake (second time)" (5% significant difference). That is, an improvement effect of acetic acid intake on menstrual pain is confirmed. That is, during menstruation, in the item "menstrual pain (amount of change)" using the VAS method, the average value from baseline was found to be greater in the "test food intake (second time)" than in the "test food intake (first time)" (reduction rate: 30.1%). Therefore, it was found that when a predetermined amount of acetic acid per day (for example, 700 mg per day or 735 mg per day) is taken continuously (for at least one menstrual cycle or more, or for at least one month), the improvement effect in the item "menstrual pain (amount of change)" is enhanced by continued intake.That is, during "menstruation," in the item "total of all MDQ items," the MDQ method showed a significant effect of decreasing the mean value from baseline for "test meal ingested (first time)" (5% significant difference). In other words, an improvement effect of acetic acid intake was observed for all menstrual symptoms and all menstrual-associated symptoms. That is, during "menstruation," in the item "total of all MDQ items," the MDQ method showed a significant effect of decreasing the mean value from baseline for "test meal ingested (second time)" (5% significant difference). In other words, an improvement effect of acetic acid intake was observed for all menstrual symptoms and all menstrual-associated symptoms. That is, during "menstruation," in the item "total of all MDQ items," the MDQ method showed a greater effect of decreasing the mean value from baseline for "test meal ingested (second time)" than for "test meal ingested (first time)" (reduction rate 5.7%). Therefore, it was found that when a predetermined amount of acetic acid is taken daily (e.g., 700 mg / day or 735 mg / day) continuously (for at least one menstrual cycle or for at least one month), the continuous intake enhances the improvement effect on the "MDQ total" items, i.e., on all menstrual symptoms and all menstrual-associated symptoms. Specifically, during menstruation, the MDQ method showed a significant decrease in the mean value from baseline for the "total" item in the "pain" domain, "test meal ingested (first time)" (10% trend). During menstruation, the MDQ method showed a significant decrease in the mean value from baseline for the "total" item in the "pain" domain, "test meal ingested (second time)" (10% trend). During menstruation, the MDQ method showed a significant decrease in the mean value from baseline for the "lower abdominal pain" item in the "pain" domain, "test meal ingested (first time)" (10% trend). That is, during menstruation, in the MDQ method, for the item "Lower abdominal pain" in the "Pain" domain, a significant decrease in the mean value compared to baseline was observed for those who "intaken the test meal (second time)" (10% trend).That is, during "menstruation," in the MDQ method, in the item "lower abdominal pain" in the "pain" domain, the average value was found to be reduced from baseline when "test meal intake (second time)" was compared to when "test meal intake (first time)" was used (reduction rate: 3.3%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the item "lower abdominal pain" in the "pain" domain was found to be enhanced by continued intake. Furthermore, this indicates that the improvement effect of continuous intake of a predetermined amount of acetic acid on "pain." That is, during "menstruation," in the MDQ method, the average value was found to be significantly reduced from baseline when "test meal intake (second time)" was used in the item "lower abdominal pain" in the "pain" domain (5% significant difference). That is, during menstruation, in the "pain" category of the MDQ method, the average value for "lower back pain" was found to be lower (35%) than that for "test meal intake (first time)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "lower back pain" category in the "pain" category was found to be enhanced by continued intake. Furthermore, this indicates that the improvement effect of continuous intake of a predetermined amount of acetic acid on "pain." That is, during menstruation, in the "headache" category of the MDQ method, the average value for "test meal intake (second time)" was found to be lower (7.7%) than that for "test meal intake (first time)." Therefore, it was found that when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the "headache" item in the "pain" category is enhanced by the continuous intake. This also confirms the improvement effect of the continuous intake of a predetermined amount of acetic acid on "pain."Specifically, during menstruation, the MDQ method showed a significant decrease in the mean value from baseline for the "tired easily" item in the "pain" domain with "test meal intake (first time)" (5% significant difference). Specifically, during menstruation, the MDQ method showed a significant decrease in the mean value from baseline for the "total" item in the "decreased concentration" domain with "test meal intake (second time)" compared to "test meal intake (first time)" (10.2% decrease). Therefore, it was found that when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "total" item in the "decreased concentration" domain was enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid is effective in improving "decreased concentration." That is, during menstruation, in the MDQ method, in the category of "Awkward movements" in the "Decreased concentration" domain, the mean value was found to be lower (40%) in the "With test meal intake (2nd time)" than in the "With test meal intake (1st time)" (reduction rate: 20%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "Awkward movements" category in the "Decreased concentration" domain is found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "decreased concentration." That is, during menstruation, in the category of "Awkward judgment" in the "Decreased concentration" domain, the mean value was found to be lower (57.1%) in the "With test meal intake (2nd time)" than in the "With test meal intake (1st time)" (reduction rate: 20%). Therefore, it was found that when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the item "dull judgment" in the "decline in concentration" category is enhanced by the continuous intake. This also shows that the improvement effect of the continuous intake of a predetermined amount of acetic acid is observed with regard to "decline in concentration."Specifically, during menstruation, the MDQ method found that in the "decline in concentration" domain, "often cuts fingers, breaks dishes, and makes other mistakes" had a greater effect of reducing the mean value from baseline in the "test meal intake (second session)" than in the "test meal intake (first session)" (a 75% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "decline in concentration" domain, "often cuts fingers, breaks dishes, and makes other mistakes," was found to be enhanced by continued intake. Furthermore, this finding indicates that the continuous intake of a predetermined amount of acetic acid is effective in improving "decline in concentration." Specifically, during menstruation, the MDQ method found that in the "total" domain, "behavioral changes" domain, "with test meal intake (second session)" had a greater effect of reducing the mean value from baseline in the "test meal intake (second session)" than in the "test meal intake (first session)" (a 16% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhanced the improvement effect in the "total" category in the "behavioral change" domain. Furthermore, this result confirmed the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "behavioral change." That is, during "menstruation," in the MDQ method, the average value from baseline was reduced in the "test meal intake (second time)" compared to the "test meal intake (first time)" category (a reduction rate of 5.6%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhanced the improvement effect in the "dozing off or going to bed" category in the "behavioral change" domain. This also indicates that continuous intake of a specified amount of acetic acid has an improving effect on "changes in behavior."Specifically, during menstruation, the MDQ method showed a greater effect of reducing the mean value from baseline for the item "Losing perseverance in work or study" in the "Behavioral Change" domain with "Test Food Intake (2nd Time)" than with "Test Food Intake (1st Time)" (a reduction of 22.2%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the item "Losing perseverance in work or study" in the "Behavioral Change" domain was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "behavioral change." Specifically, during menstruation, the MDQ method showed a greater effect of reducing the mean value from baseline for the item "Losing perseverance in work or study" in the "Behavioral Change" domain with "Test Food Intake (2nd Time)" than with "Test Food Intake (1st Time)" (a reduction of 28.6%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhanced the improvement effect of the item "becoming lazy" in the "behavioral change" domain. This also confirmed the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "behavioral change." That is, during "menstruation," the MDQ method showed that the average value of the item "wanting to avoid social interactions" in the "behavioral change" domain was reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a reduction rate of 50%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhanced the improvement effect of the item "wanting to avoid social interactions" in the "behavioral change" domain. This also confirmed the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "behavioral change."That is, during menstruation, in the MDQ method, in the category of "feeling nauseous" in the "autonomic nervous system disorder" domain, the average score was found to be lower (25%) in the "test meal intake (second time)" than in the "test meal intake (first time)" category. Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "feeling nauseous" category in the "autonomic nervous system disorder" domain was found to be enhanced by continued intake. Furthermore, this indicates that the improvement effect of continuous intake of a predetermined amount of acetic acid on "autonomic nervous system disorder" was found. That is, during menstruation, in the category of "feeling dizzy" in the MDQ method, the average score was found to be lower (60%) in the "test meal intake (second time)" than in the "test meal intake (first time)" category. Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "dizziness" item in the "autonomic nervous system imbalance" category. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "autonomic nervous system imbalance." That is, during "menstruation," the MDQ method showed that the mean value from baseline in the "total" item in the "water retention" category was reduced by 9.3% in the "test meal intake (second time)" compared to the "test meal intake (first time)." This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "water retention." That is, during menstruation, in the MDQ method, for the item "feeling pain in the breasts" in the "water retention" domain, the average value compared to baseline was found to be lower in the "test meal intake (second time)" than in the "test meal intake (first time)" category (reduction rate 22.2%).Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "breast pain" item in the "water retention" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "water retention." That is, during "menstruation," the MDQ method showed that the mean value for the "skin roughness" item in the "water retention" domain was reduced from baseline by 14.3% in the "test meal intake (second time)" compared to the "test meal intake (first time)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake enhances the improvement effect of the "skin roughness" item in the "water retention" domain. Furthermore, this result indicates that continuous intake of a predetermined amount of acetic acid has an improving effect on "water retention." Specifically, during menstruation, in the MDQ method, in the category "Swelling (abdomen, breasts, legs, etc.)" in the "water retention" domain, a significant decrease in the mean value from baseline was observed in the "test meal intake (second time)" group (10% trend). Specifically, during menstruation, in the category "Swelling (abdomen, breasts, legs, etc.)" in the "water retention" domain, a significant decrease in the mean value from baseline was observed in the "test meal intake (second time)" group compared with the "test meal intake (first time)" group (10% decrease). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), continuous intake of acetic acid enhances the improvement effect of the "swelling (abdomen, breasts, legs, etc.)" category in the "water retention" domain. This also indicates that continuous intake of a prescribed amount of acetic acid has an improving effect on "water retention." In other words, during menstruation, in the MDQ method, in the "total" item in the "negative emotion" domain, a significant decrease in the mean value was observed compared to the baseline for "test meal intake (first time)" (10% trend).That is, during menstruation, in the MDQ method, in the item "feeling upset" in the "negative emotion" domain, the mean value was found to be reduced from baseline by 40% when "test meal intake (first time)" was compared with "test meal intake (second time)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "feeling upset" item in the "negative emotion" domain was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "negative emotion." That is, during menstruation, in the MDQ method, the mean value was found to be significantly reduced from baseline when "test meal intake (first time)" was taken (5% significant difference) in the item "feeling depressed" in the "negative emotion" domain. Specifically, during menstruation, the MDQ method found that the mean value for the "feeling depressed" item in the "negative emotion" domain was significantly reduced from baseline in the "test meal intake (second time)" category (5% significant difference). Specifically, during menstruation, the MDQ method found that the mean value for the "feeling depressed" item in the "negative emotion" domain was significantly reduced from baseline in the "test meal intake (second time)" category compared to the "test meal intake (first time)" category (12.5% ​​reduction). Therefore, it was found that continuous intake of a predetermined amount of acetic acid per day (e.g., 700 mg per day or 735 mg per day) (for at least one menstrual cycle or more, or for at least one month) enhanced the improvement effect of the "feeling depressed" item in the "negative emotion" domain. Furthermore, this finding indicates that continuous intake of a predetermined amount of acetic acid is effective in improving "negative emotion." That is, during menstruation, in the MDQ method, for the item "restless" in the "negative emotions" domain, the effect of "test meal intake (second time)" being greater than "test meal intake (first time)" in decreasing the average value from baseline (reduction rate 20%).Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "restless" item in the "negative emotion" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid on "negative emotion." That is, during "menstruation," the MDQ method showed that the mean value for the "becoming obedient" item in the "elevated mood" domain decreased from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a decrease rate of 13.3%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "becoming obedient" item in the "elevated mood" domain. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid on "mood elevation." Specifically, during menstruation, the MDQ method showed a decrease in the mean value from baseline for the "total" item in the "control" area when the test meal was taken (second time) compared to when the test meal was taken (first time) (a decrease of 28.6%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was taken continuously (for at least one menstrual cycle or more, or for at least one month), the improvement effect of continuous intake on the "total" item in the "control" area was found to be enhanced. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid on the "control." Specifically, during menstruation, the MDQ method showed a decrease in the mean value from baseline for the "test meal taken (second time)" compared to when the test meal was taken (first time) (a decrease of 50%). Therefore, it was found that when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect on the item "tinnitus" in the "control" area increases with continued intake.Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on the "control" category. That is, during "menstruation," in the MDQ method, in the "chest tightness" category in the "control" area, the mean value was found to be reduced from baseline in the "test meal intake (second time)" category compared to the "test meal intake (first time)" category (a 25% decrease). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhances the improvement effect on the "chest tightness" category in the "control" category. Also, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on the "control." That is, during "menstruation," in the MDQ method, in the "total" category in the "PMS" area, the mean value was found to be significantly reduced from baseline in the "test meal intake (first time)" category (a 10% tendency). That is, during "menstruation," in the "total" category in the "PMS" area of ​​the MDQ method, the average value was significantly reduced from baseline in the "test meal intake (second time)" category (5% significant difference). That is, during "menstruation," in the "total" category in the "PMS" area of ​​the MDQ method, the average value was significantly reduced from baseline in the "test meal intake (second time)" category compared to the "test meal intake (first time)" category (22.7% reduction). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), the improvement effect in the "total" category in the "PMS" area was found to be enhanced by continued intake. Furthermore, this indicates that the improvement effect of continuous intake of a predetermined amount of acetic acid on "PMS" is observed. That is, during menstruation, in the MDQ method, for the item "feeling bloated" in the "PMS" domain, the average value from baseline was found to be lower in the "test meal intake (second time)" than in the "test meal intake (first time)" category (reduction rate 14.3%).Therefore, when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg) continuously (for at least one menstrual cycle or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "abdominal bloating" item in the "PMS" domain. This also confirms the improvement effect of the continuous intake of a predetermined amount of acetic acid with regard to "PMS." That is, during "menstruation," the MDQ method showed that the average value of the "irritability, quarrels with close friends, sometimes harshly scolds children" item in the "PMS" domain was reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (reduction rate: 33.3%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg / day or 735 mg / day) is continuously taken (for at least one menstrual cycle or for at least one month), the continuous intake of acetic acid enhances the improvement effect on the "PMS" category of "irritability, arguing with close friends, sometimes harshly scolding children." This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid on "PMS." Specifically, during menstruation, the MDQ method showed a significant decrease in the mean value from baseline for the "PMS" category of "loss of confidence, blaming myself" in the "PMS" category with test meal intake (second session)" (10% trend). During menstruation, the MDQ method showed a significant decrease in the mean value from baseline for the "PMS" category of "loss of confidence, blaming myself" in the "PMS" category with test meal intake (second session)" compared to the "PMS" category with test meal intake (first session) (66.7% decrease). Therefore, it was found that when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the item "Loss of confidence, self-blame" in the "PMS" category is enhanced by the continuous intake. This also confirms the improvement effect of the continuous intake of a predetermined amount of acetic acid on "PMS."Specifically, during menstruation, the MDQ method found that for the item "Taking time off work" in the "PMS" domain, the average value was reduced from baseline by 100% when the test meal was taken "with test meal (second time)" compared to the item "with test meal (first time)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "Taking time off work" item in the "PMS" domain was enhanced by continued intake. Furthermore, this finding indicates that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "PMS." Specifically, during menstruation, the MDQ method found that for the item "Changes in food preferences (e.g., feeling attached to certain foods)" in the "Other" domain, the average value was reduced from baseline by 14.3% when the test meal was taken "with test meal (second time)" compared to the item "with test meal (first time)." Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "Changes in food preferences (e.g., obsession with specific foods)" item in the "Other" category. Furthermore, this result indicates that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "Other" menstrual symptoms. That is, during "menstruation," in the "Other" category, the MDQ method showed that the mean value from baseline was reduced in the "Test meal intake (second time)" compared to the "Test meal intake (first time)" (reduction rate: 27.3%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "Constipation" item in the "Other" category. This also indicates that the "other" menstrual symptoms can be improved by continuously taking a prescribed amount of acetic acid.

[0138]

[0139] <Changes in menstrual pain and menstrual symptoms during menstruation (in women in their 20s)> The results are shown in Table 6. That is, for women "during menstruation (in their 20s)," the VAS method showed a significant effect of decreasing the mean value from baseline in the "menstrual pain" category for women "with test food intake (first time)" (5% significant difference). That is, an improvement effect of acetic acid intake on menstrual pain is observed. That is, for women "during menstruation (in their 20s)," the VAS method showed a significant effect of decreasing the mean value from baseline in the "menstrual pain" category for women "with test food intake (second time)" (5% significant difference). That is, an improvement effect of acetic acid intake on menstrual pain is observed. That is, for women "during menstruation (in their 20s)," the VAS method showed a significant effect of decreasing the mean value from baseline in the "menstrual pain" category for women "with test food intake (second time)" compared to women "with test food intake (first time)" (reduction rate 7.8%). Therefore, it was found that when a predetermined amount of acetic acid per day (for example, 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect in the category of "menstrual pain" is enhanced by continued intake. That is, in the category of "menstrual pain (change)" in "menstruation (20s)", a significant effect of decreasing the mean value from baseline in the category of "menstrual pain (change)" in "test food intake (first time)" was observed using the VAS method (5% significant difference). That is, an improvement effect of acetic acid intake on menstrual pain is observed. That is, in the category of "menstruation (20s)", a significant effect of decreasing the mean value from baseline in "menstrual pain (change)" in "test food intake (second time)" was observed using the VAS method (5% significant difference). That is, an improvement effect of acetic acid intake on menstrual pain is observed. That is, in the "menstrual period (in their 20s)" category, the VAS method showed that the average value from baseline was reduced more in the "test meal intake (second time)" category than in the "test meal intake (first time)" category (reduction rate: 9.1%). Therefore, it was found that when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), the improvement effect in the category of "menstrual pain (change)" is enhanced by continued intake.That is, for "menstrual period (20s)", in the item "total of all MDQ items", the MDQ method showed a significant effect of decreasing the mean value from baseline for "test meal ingested (1st time)" (5% significant difference). That is, an improvement effect of acetic acid intake was observed for all menstrual symptoms and all menstrual-associated symptoms. That is, for "menstrual period (20s)", in the item "total of all MDQ items", the MDQ method showed a significant effect of decreasing the mean value from baseline for "test meal ingested (2nd time)" (10% tendency). That is, an improvement effect of acetic acid intake was observed for all menstrual symptoms and all menstrual-associated symptoms. That is, for "menstrual period (20s)", in the item "total of all MDQ items", the MDQ method showed a significant effect of decreasing the mean value from baseline for "test meal ingested (2nd time)" compared to "test meal ingested (1st time)" (decrease rate 0.9%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhances the improvement effect on the "MDQ total" item, i.e., on all menstrual symptoms and all menstrual-associated symptoms. That is, in "menstruation (in their 20s)," in the MDQ method, the average value of the "total" item in the "pain" domain was found to decrease from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a decrease rate of 6%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhances the improvement effect on the "total" item in the "pain" domain. Furthermore, this indicates that continuous intake of a predetermined amount of acetic acid has an improvement effect on "pain." That is, for those "during menstruation (in their 20s)", in the "pain" domain of the MDQ method, the average value for "lower abdominal pain" was found to be lower than that for "test meal intake (first time)" (reduction rate 4.2%).Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "lower abdominal pain" item in the "pain" category. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "pain." Specifically, in the "menstrual period (in people in their 20s)" category, the MDQ method showed a decrease in the average value from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" category (a decrease rate of 35.3%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "lower abdominal pain" item in the "pain" category. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "pain." Specifically, in the "menstrual period (20s)" category, the MDQ method showed a greater reduction in the average value of the "headache" item in the "pain" domain with "test meal intake (2nd time)" compared to "test meal intake (1st time)" (a reduction of 18.2%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "headache" item in the "pain" domain is enhanced by continued intake. Furthermore, this indicates that the improvement effect of continuous intake of a predetermined amount of acetic acid is observed with regard to "pain." Specifically, in the "menstrual period (20s)" category, the MDQ method showed a greater reduction in the average value of the "total" item in the "decreased concentration" domain with "test meal intake (2nd time)" compared to "test meal intake (1st time)" (a reduction of 8.1%). Therefore, it was found that when acetic acid is taken in a predetermined amount per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect in the "total" category in the "decline in concentration" area increases with continued intake.This also confirms the improvement effect of continuous intake of a specified amount of acetic acid on "decline in concentration." That is, in "menstrual period (in their 20s)," in the MDQ method, in the "decline in concentration" category, "poor judgment" was found to have a greater effect of reducing the average value from baseline in the "test meal intake (second time)" than in the "test meal intake (first time)" category (a 60% reduction). Therefore, when a specified amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of continuous intake on the "poor judgment" category in the "decline in concentration" category is found to be enhanced. This also confirms the improvement effect of continuous intake of a specified amount of acetic acid on "decline in concentration." Specifically, in the "menstrual period (20s)" category, the MDQ method found that the average value for the "I often cut my fingers, break dishes, and make other mistakes" item in the "decline in concentration" domain was reduced by 66.7% (reduction rate) when the "test meal intake (2nd time)" was compared to the "test meal intake (1st time)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "I often cut my fingers, break dishes, and make other mistakes" item in the "decline in concentration" domain was enhanced by continued intake. Furthermore, this finding indicates that the continuous intake of a predetermined amount of acetic acid is effective in improving "decline in concentration." Specifically, in the "menstrual period (20s)" category, the MDQ method found that the average value for the "total" item in the "change in behavior" domain was reduced by 2.8% (reduction rate) when the "test meal intake (2nd time)" was compared to the "test meal intake (1st time)." Therefore, when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the "total" item in the "change in behavior" area is found to be enhanced by the continuous intake. This also shows that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "change in behavior."Specifically, in the "menstrual period (20s)" category, the MDQ method showed a greater reduction in the mean value from baseline for the "dozing off or getting into bed" category in the "behavioral change" category with "test meal intake (2nd time)" than with "test meal intake (1st time)" (a reduction of 6.7%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "dozing off or getting into bed" category in the "behavioral change" category was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "behavioral change." Specifically, in the "menstrual period (20s)" category, the MDQ method showed a greater reduction in the mean value from baseline for the "feeling dizzy" category in the "autonomic nervous system imbalance" category with "test meal intake (2nd time)" than with "test meal intake (1st time)" (a reduction of 75%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "dizziness" item in the "autonomic nervous system imbalance" category. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "autonomic nervous system imbalance." Specifically, in the "menstrual period (in their 20s)" category, the MDQ method showed a decrease in the mean value from baseline in the "total" item in the "water retention" category for "test meal intake (second time)" compared to "test meal intake (first time)" (7% decrease). This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "water retention."Specifically, in the "menstrual period (20s)" category, the MDQ method showed a greater reduction in the average value of the "breast pain" item in the "water retention" domain with "test meal intake (2nd time)" compared to "test meal intake (1st time)" (a 12.5% ​​reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "breast pain" item in the "water retention" domain is enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "water retention." Specifically, in the "menstrual period (20s)" category, the MDQ method showed a greater reduction in the average value of the "skin roughness" item in the "water retention" domain with "test meal intake (2nd time)" compared to "test meal intake (1st time)" (a 9.1% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "rough skin" category in the "water retention" category. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "water retention." Specifically, in the "menstrual period (in their 20s)" category, the MDQ method showed that the mean value for the "swelling (abdomen, breasts, legs, etc.)" category in the "water retention" category was reduced by 6.3% (reduction rate) compared with the "test meal intake (first time)" category. Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "swelling (abdomen, breasts, legs, etc.)" category in the "water retention" category. This also indicates that continuous intake of a prescribed amount of acetic acid has an improving effect on "water retention."Specifically, for those in their 20s who were menstruating, the MDQ method showed a significant reduction in the mean value of "feeling depressed" in the "negative emotion" domain with "test meal intake (first time)" compared to baseline (a 10% trend). Specifically, for those in their 20s who were menstruating, the MDQ method showed a significant reduction in the mean value of "feeling tense" in the "negative emotion" domain with "test meal intake (second time)" compared to "feeling tense" in "feeling tense" (a 50% reduction). Therefore, it was found that continuous intake of a prescribed amount of acetic acid per day (e.g., 700 mg per day or 735 mg per day) (for at least one menstrual cycle or more, or for at least one month) enhanced the improvement effect of the "feeling tense" item in the "negative emotion" domain. Furthermore, this indicates that continuous intake of a prescribed amount of acetic acid is effective in improving "negative emotion." That is, in the "menstrual period (20s)" category, the MDQ method showed a decrease in the average value from baseline for the "chest tightness" category in the "control" area when the "test meal intake (2nd time)" was compared to the "test meal intake (1st time)" (a decrease of 25%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "chest tightness" category in the "control" area was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improvement effect on the "control". That is, in the "menstrual period (20s)" category, the MDQ method showed a decrease in the average value from baseline for the "test meal intake (2nd time)" compared to the "test meal intake (1st time)" (a decrease of 18.5%). Therefore, when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect in the "total" category in the "PMS" area is found to increase with continued intake. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid on "PMS."Specifically, in the "menstrual period (20s)" category, the MDQ method showed a significant reduction in the average value from baseline for the "feeling of abdominal bloating" category in the "PMS" category when the "test meal was taken (2nd time)" was compared to the "test meal was taken (1st time)" category (a 27.3% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was taken continuously (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "feeling of abdominal bloating" category in the "PMS" category was found to be enhanced by continued intake. Furthermore, this indicates that the improvement effect of continuous intake of a predetermined amount of acetic acid on "PMS" is recognized. Specifically, in the "menstrual period (20s)" category, the MDQ method showed a significant reduction in the average value from baseline for the "feeling of loss of confidence, blaming oneself" category in the "PMS" category when the "test meal was taken (2nd time)" was taken (a 10% tendency). Specifically, in the "menstrual period (20s)" category, the MDQ method showed a greater reduction in the average value from baseline for the "loss of confidence, self-blame" category in the "PMS" category with "test meal intake (2nd time)" than with "test meal intake (1st time)" (a 60% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "loss of confidence, self-blame" category in the "PMS" category is enhanced by continued intake. Furthermore, this demonstrates the improvement effect of continuous intake of a predetermined amount of acetic acid on "PMS." Specifically, in the "menstrual period (20s)" category, the MDQ method showed a greater reduction in the average value from baseline for the "test meal intake (2nd time)" than with "test meal intake (1st time)" in the "PMS" category (a 100% reduction). Therefore, it was found that when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of "taking time off work" in the "PMS" category is enhanced by the continuous intake. This also confirms the improvement effect of the continuous intake of a predetermined amount of acetic acid on "PMS."That is, in the "menstrual period (in their 20s)" category, the MDQ method showed that the average value for "constipation" in the "other" category was reduced by 12.5% ​​(decrease rate) compared to "test meal intake (first time)." Therefore, when a predetermined amount of acetic acid (for example, 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for one month or more), the improvement effect of the "constipation" category in the "other" category was found to be enhanced by continued intake. Furthermore, this shows that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "other" menstrual symptoms.

[0140]

[0141] <Changes in menstrual pain and menstrual symptoms during menstruation (30s to 40s)> The results are shown in Table 7. That is, in the "menstrual pain" category "during menstruation (30s to 40s)," the VAS method showed a greater effect of reducing the mean value from baseline in the "test food intake (second session)" compared to the "test food intake (first session)" (a reduction rate of 54.1%). Therefore, it was found that when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), the improvement effect in the "menstrual pain" category is enhanced by continued intake. That is, in the "menstrual pain" category "during menstruation (30s to 40s)," the VAS method showed a greater effect of reducing the mean value from baseline in the "test food intake (second session)" compared to the "test food intake (first session)" (a reduction rate of 134.2%). Therefore, it was found that when a predetermined amount of acetic acid per day (e.g., 700 mg per day or 735 mg per day) was taken continuously (for at least one menstrual cycle or more, or for at least one month), continuous intake enhanced the improvement effect in the category of "menstrual pain (change)." That is, in "menstruation (30s-40s)," the MDQ method showed that the mean value from baseline in the category of "total of all MDQ items" was reduced in the "test meal intake (second time)" compared to the "test meal intake (first time)" (decrease rate: 19.6%). Therefore, it was found that when a predetermined amount of acetic acid per day (e.g., 700 mg per day or 735 mg per day) was taken continuously (for at least one menstrual cycle or more, or for at least one month), continuous intake enhanced the improvement effect in the category of "total of all MDQ items," i.e., general menstrual symptoms and general menstrual-associated symptoms. That is, for those "during menstruation (30s-40s)", in the MDQ method, for the item "lower back pain" in the "pain" domain, a significant effect of a decrease in the mean value from baseline was observed for those "with test meal intake (2nd time)" (5% significant difference). That is, for those "during menstruation (30s-40s)", in the item "lower back pain" in the "pain" domain, a significant effect of a decrease in the mean value from baseline was observed for those "with test meal intake (2nd time)" compared to those "with test meal intake (1st time)" (reduction rate 33.3%).Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "lower back pain" item in the "pain" domain. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "pain." Specifically, in the MDQ method, in the "total" item in the "decreased concentration" domain, the average value was found to decrease from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a decrease rate of 16.7%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "total" item in the "decreased concentration" domain. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "decreased concentration." Specifically, in the MDQ method, for subjects in their 30s and 40s who were menstruating, the average value for the "becoming awkward" category in the "decreased ability to concentrate" domain was found to be lower (66.7%) in the "with test meal intake (second session)" than in the "with test meal intake (first session)" category. Therefore, it was found that continuous intake of a prescribed amount of acetic acid (e.g., 700 mg per day or 735 mg per day) for at least one menstrual cycle or for at least one month enhances the improvement effect of the "becoming awkward" category in the "decreased ability to concentrate" domain. Furthermore, this finding indicates that continuous intake of a prescribed amount of acetic acid is effective in improving "decreased ability to concentrate." Specifically, in the MDQ method, for subjects in their 30s and 40s who were menstruating, the average value for the "becoming awkward" category in the "decreased ability to concentrate" domain was found to be lower (33.3%) in the "with test meal intake (second session)" than in the "with test meal intake (first session)" category.Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "decline in concentration" item in the "decline in concentration" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "decline in concentration." That is, in the MDQ method, for the "decline in concentration" domain item "dull judgment" in the "decline in concentration" domain, the mean value was found to be reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (reduction rate: 50%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhances the improvement effect of the "dull judgment" item in the "decline in concentration" domain. This also confirms the improvement effect of continuous intake of a prescribed amount of acetic acid on "decreased concentration." Specifically, in "menstrual period (30s-40s)," the MDQ method revealed that in the "decreased concentration" category, "I often make mistakes, such as cutting my fingers or breaking dishes," the mean value from baseline was reduced in "test meal intake (2nd time)" compared to "test meal intake (1st time)" (100% reduction). Therefore, when a prescribed amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of continuous intake was found to be enhanced in the "decreased concentration" category, "I often make mistakes, such as cutting my fingers or breaking dishes." This also confirms the improvement effect of continuous intake of a prescribed amount of acetic acid on "decreased concentration." That is, in the "menstrual period (30s-40s)" category, in the "total" item in the "change in behavior" area of ​​the MDQ method, the effect of "test meal intake (2nd time)" being greater than "test meal intake (1st time)" in terms of the average value compared to baseline (reduction rate 50%).Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhanced the improvement effect on the "total" item in the "behavioral change" domain. This also confirmed the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "behavioral change." Specifically, in the MDQ method, for the item "Losing perseverance in work or study" in the "behavioral change" domain, the average value was found to be reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a reduction rate of 66.7%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhanced the improvement effect on the item "Losing perseverance in work or study" in the "behavioral change" domain. This also confirms the improvement effect of continuous intake of a specified amount of acetic acid on "behavioral change." That is, in "menstrual period (30s-40s)," the MDQ method showed that in the item "becoming lazy" in the "behavioral change" domain, the mean value was reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (reduction rate: 66.7%). Therefore, when a specified amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of continuous intake on the item "becoming lazy" in the "behavioral change" domain was found to be enhanced. This also confirms the improvement effect of continuous intake of a specified amount of acetic acid on "behavioral change." That is, in the "menstrual period (30s-40s)" category, in the "changes in behavior" area of ​​the MDQ method, the average value compared to baseline was found to be lower in the "test meal intake (2nd time)" category than in the "test meal intake (1st time)" category (reduction rate 100%).Therefore, when a predetermined amount of acetic acid is taken daily (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the item "wanting to avoid social interactions" in the "behavioral change" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "behavioral change." Specifically, in the MDQ method, for the item "feeling nauseous" in the "autonomic nervous system imbalance" domain, the average value was found to decrease from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (100% reduction). Therefore, when a predetermined amount of acetic acid is taken daily (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the item "feeling nauseous" in the "autonomic nervous system imbalance" domain. Furthermore, this result indicates that continuous intake of a prescribed amount of acetic acid is effective in improving "autonomic nervous system imbalance." Specifically, in the "menstrual period (30s-40s)," the MDQ method showed a significant decrease in the mean value from baseline in the "total" category in the "water retention" domain for "test meal intake (2nd time)" (10% trend). Specifically, in the "menstrual period (30s-40s)," the MDQ method showed a significant decrease in the mean value from baseline in the "total" category for "test meal intake (2nd time)" compared to "test meal intake (1st time)" (18.2% decrease). Therefore, when a prescribed amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously ingested (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhanced the improvement effect in the "total" category in the "water retention" domain. This also indicates that continuous intake of a prescribed amount of acetic acid is effective in improving "water retention."Specifically, in the "menstrual period (30s-40s)" category, the MDQ method showed a significant reduction in the mean value from baseline for the "breast pain" category in the "water retention" category when the "test meal was ingested (2nd time)" was compared to the "test meal was ingested (1st time)" (100% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously ingested (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "breast pain" category in the "water retention" category was found to be enhanced by continued ingestion. Furthermore, this indicates that the continuous ingestion of a predetermined amount of acetic acid has an improving effect on "water retention." Specifically, in the "menstrual period (30s-40s)" category, the MDQ method showed a significant reduction in the mean value from baseline for the "test meal was ingested (2nd time)" category in the "water retention" category (5% significant difference). Specifically, in the "menstrual period (30s-40s)" category, the MDQ method showed a greater reduction in the mean value from baseline for the "skin roughness" category in the "water retention" domain when the "test meal intake (2nd time)" was compared to the "test meal intake (1st time)" category (a reduction of 33.3%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously ingested (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhanced the improvement effect of the "skin roughness" category in the "water retention" domain. Furthermore, this demonstrated the improvement effect of the continuous intake of a predetermined amount of acetic acid on "water retention." Specifically, in the "menstrual period (30s-40s)" category, the MDQ method showed a greater reduction in the mean value from baseline for the "test meal intake (2nd time)" category in the "water retention" domain when the "test meal intake (1st time)" was compared to the "test meal intake (2nd time)" category (a reduction of 25%). Therefore, it was found that when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the item "Swelling (abdomen, breasts, legs, etc.)" in the "water retention" area is enhanced by continued intake.This also confirms the improvement effect of continuous intake of a specified amount of acetic acid on "water retention." That is, in "menstruation (30s-40s)," in the MDQ method, in the "total" category in the "negative emotion" domain, the mean value was found to be reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" category (a reduction rate of 21.4%). Therefore, when a specified amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), the improvement effect of continuous intake on the "total" category in the "negative emotion" domain was found to be enhanced. This also confirms the improvement effect of continuous intake of a specified amount of acetic acid on "negative emotion." Specifically, in the MDQ method, for the "Mood upset" category in the "Negative Emotion" domain, the mean value was found to be lower (75%) for those in the "Test meal intake (second session)" than for those in the "Test meal intake (first session)" category. Therefore, it was found that when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "Mood upset" category in the "Negative Emotion" domain was enhanced by continued intake. Furthermore, this finding indicates that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "negative emotion." Specifically, in the MDQ method, for those in their "30s and 40s" during menstruation, the mean value was found to be lower (33.3%) for those in the "Test meal intake (second session)" than for those in the "Test meal intake (first session)" category. Therefore, it was found that when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the item "feeling depressed" in the "negative emotions" domain is enhanced by the continuous intake. This also confirms the improvement effect of the continuous intake of a predetermined amount of acetic acid on "negative emotions."Specifically, in the MDQ for women in their 30s and 40s who were menstruating, the average score for "restless" in the "negative emotion" domain was found to be lower (100% reduction) when "test meal intake (second session)" was used than when "test meal intake (first session)" was used. Therefore, it was found that continuous intake of a prescribed amount of acetic acid per day (e.g., 700 mg per day or 735 mg per day) (for at least one menstrual cycle or more, or for at least one month) enhanced the improvement effect of the "restless" item in the "negative emotion" domain. Furthermore, this finding confirmed the improvement effect of continuous intake of a prescribed amount of acetic acid on "negative emotion." Specifically, in the MDQ for women in their 30s and 40s who were menstruating, the average score for "total" in the "elevated emotion" domain was found to be lower (20% reduction) when "test meal intake (second session)" was used than when "test meal intake (first session)" was used. Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect in the "total" category in the "mood enhancement" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "mood enhancement." Specifically, in the MDQ method, for "menstrual period (30s-40s)," the average value for "feeling gentle" in the "mood enhancement" domain was found to decrease from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a decrease rate of 33.3%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhances the improvement effect in the "feeling gentle" category in the "mood enhancement" domain. This also indicates that continuous intake of a prescribed amount of acetic acid has an improving effect on "elevated mood."Specifically, in the "menstrual period (30s-40s)" category, the MDQ method showed a decrease in the average value from baseline for the "becoming more open-minded" category in the "mood elevation" domain when the "test meal intake (2nd time)" was compared to the "test meal intake (1st time)" (a decrease of 60%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "becoming more open-minded" category in the "mood elevation" domain was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "mood elevation." Specifically, in the "menstrual period (30s-40s)" category, the MDQ method showed a decrease in the average value from baseline for the "test meal intake (2nd time)" compared to the "test meal intake (1st time)" (a decrease of 100%) in the "total" category in the "control" domain. Therefore, when a predetermined amount of acetic acid per day (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake enhances the improvement effect in the "total" category in the "control" area. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid for the "control." Specifically, in the "menstrual period (30s-40s)" category, the MDQ method showed a decrease in the mean value from baseline for the "test meal intake (second time)" compared to the "test meal intake (first time)" category (a reduction rate of 100%). This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid for the "tinnitus" category in the "control" area.Specifically, in the "menstrual period (30s-40s)" category, the MDQ method showed a greater reduction in the mean value from baseline for the "numbness in hands and feet" category in the "control" area when the "test meal intake (second time)" was compared to the "test meal intake (first time)" category (a reduction of 100%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "numbness in hands and feet" category in the "control" area was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improvement effect on the "control" category. Specifically, in the "menstrual period (30s-40s)" category, the MDQ method showed a greater reduction in the mean value from baseline for the "test meal intake (second time)" category compared to the "test meal intake (first time)" category (a reduction of 29.4%). Therefore, when a predetermined amount of acetic acid is taken daily (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), it was found that the improvement effect of the "total" item in the "PMS" domain is enhanced by continued intake. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "PMS." That is, in the MDQ method, for the item "irritability, fights with close friends, sometimes harshly scolds children" in the "PMS" domain in "menstruation (30s-40s)," the average value was found to be reduced from baseline in the "test food intake (2nd time)" compared to the "test food intake (1st time)" (reduction rate: 40%). Therefore, it was found that when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the item "irritability, quarrels with close friends, sometimes scolding children harshly" in the "PMS" category is enhanced by the continuous intake. This also shows that the improvement effect of the continuous intake of a predetermined amount of acetic acid is effective in "PMS."Specifically, in the "menstrual period (30s-40s)" category, the MDQ method showed a greater reduction in the mean value from baseline for the "change in appetite" category in the "PMS" domain when the "test meal intake (2nd time)" was compared to the "test meal intake (1st time)" category (a 25% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the continued intake of acetic acid enhanced the improvement effect on the "change in appetite" category in the "PMS" domain. Furthermore, this demonstrates the improvement effect of the continuous intake of a predetermined amount of acetic acid on "PMS." Specifically, in the "menstrual period (30s-40s)" category, the MDQ method showed a greater reduction in the mean value from baseline for the "test meal intake (2nd time)" category compared to the "test meal intake (1st time)" category (a 75% reduction). Therefore, when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), it was found that continued intake increases the improvement effect on the item "Loss of confidence, self-blame" in the "PMS" domain. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "PMS." Specifically, in the "during menstruation (30s-40s)" category, the MDQ method found that the average value for the item "Changes in food preferences (e.g., feeling attached to certain foods)" in the "Other" domain was reduced compared to the "test meal intake (1st)" category by 33.3% (decrease rate). Therefore, it was found that when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the item "changes in food preferences (e.g., feeling attached to a particular food)" in the "Other" category is enhanced by continued intake. This also shows that the improvement effect of continuous intake of a predetermined amount of acetic acid is observed for "other" menstrual symptoms.Specifically, for women in their 30s and 40s who were menstruating, the MDQ method showed a greater reduction in the mean value from baseline for the "constipated" category in the "other" category when the "test meal was taken (second time)" was compared to the "test meal was taken (first time)" category (a reduction of 66.7%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhanced the improvement effect on the "constipated" category in the "other" category. Furthermore, this demonstrated the improvement effect of the continuous intake of a predetermined amount of acetic acid on "other" menstrual symptoms. Specifically, for women in their 30s and 40s who were menstruating, the MDQ method showed a greater reduction in the mean value from baseline for the "test meal was taken (second time)" than for the "test meal was taken (first time)" category in the "other" category (a reduction of 66.7%). Therefore, it was found that when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the item "loose stomach (slight diarrhea)" in the "Other" category is enhanced by the continuous intake. This also shows that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "Other" menstrual symptoms.

[0142]

[0143] <Changes in menstrual pain and menstrual symptoms before menstruation (all participants)> The results are shown in Table 8. That is, in the "premenstrual" period, in the item "total of all MDQ items," the MDQ method showed a significant effect of decreasing the mean value from baseline in the "test food intake (first session)" category (5% significant difference). That is, an improvement effect of acetic acid intake was observed for all menstrual symptoms and all menstrual symptoms. That is, in the "premenstrual" period, in the item "total of all MDQ items," the MDQ method showed a significant effect of decreasing the mean value from baseline in the "test food intake (second session)" category (5% significant difference). That is, an improvement effect of acetic acid intake was observed for all menstrual symptoms and all menstrual symptoms. That is, in the "premenstrual" period, in the item "total of all MDQ items," the MDQ method showed a significant effect of decreasing the mean value from baseline in the "test food intake (second session)" category compared to the "test food intake (first session)" category (reduction rate 5.7%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhances the improvement effect on the "MDQ total" item, i.e., on all menstrual symptoms and all menstrual-associated symptoms. That is, in the "premenstrual" period, in the MDQ method, the average value of the "total" item in the "pain" domain was reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a reduction rate of 2.2%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhances the improvement effect on the "total" item in the "pain" domain. Furthermore, this indicates that continuous intake of a predetermined amount of acetic acid has an improvement effect on "pain." That is, "before menstruation," in the "pain" domain of the MDQ method, the average value from baseline was found to be lower in the "test meal intake (second time)" than in the "test meal intake (first time)" category (reduction rate 27.8%).Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "lower abdominal pain" item in the "pain" domain. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "pain." That is, in the "premenstrual" period, the MDQ method showed that the average value of the "headache" item in the "pain" domain was reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a reduction rate of 13.3%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "headache" item in the "pain" domain. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "pain." That is, in the "premenstrual" period, the MDQ method showed that the average value of the "body pain" item in the "pain" domain was significantly reduced from baseline when the test meal was ingested (second time) compared to when the test meal was ingested (first time) (a 66.7% reduction rate). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously ingested (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "body pain" item in the "pain" domain was found to be enhanced by continued ingestion. Furthermore, this shows that the improvement effect of continuous ingestion of a predetermined amount of acetic acid on "pain" was observed. That is, in the "premenstrual" period, the MDQ method showed that the average value of the "tired easily" item in the "pain" domain was significantly reduced from baseline when the test meal was ingested (first time) (a 5% significant difference). That is, in the "premenstrual" period, in the "pain" domain of the MDQ method, the average value for the "easily tired" item was found to be significantly reduced compared to baseline in the "test meal intake (second time)" category (10% trend).That is, in the "premenstrual" period, in the MDQ method, in the "decline in concentration" category, the mean value was significantly reduced from baseline in the "test food intake (first time)" category (5% significant difference). That is, in the "premenstrual" period, in the "can't organize my thoughts" category in the "decline in concentration" category, the mean value was significantly reduced from baseline in the "test food intake (second time)" category compared to the "test food intake (first time)" category (40% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "can't organize my thoughts" category in the "decline in concentration" category was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid is effective in improving "decline in concentration." Specifically, in the "premenstrual" period, the MDQ method found that the average value for the "Frequent failures, such as cutting fingers or breaking dishes," in the "Decreased concentration" domain was reduced by 25% (reduction rate) when the "test meal intake (second session)" was compared with the "test meal intake (first session)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "Frequent failures, such as cutting fingers or breaking dishes," in the "Decreased concentration" domain was enhanced by continued intake. Furthermore, this finding indicates that the continuous intake of a predetermined amount of acetic acid is effective in improving "decreased concentration." Specifically, in the "premenstrual" period, the MDQ method found that the average value for the "total" domain in the "changes in behavior" domain was reduced by 14.3% (reduction rate) when the "test meal intake (second session)" was compared with the "test meal intake (first session)." Therefore, it was found that when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect in the "total" category in the "behavioral change" area increases with continued intake.Furthermore, this result indicates that the continuous intake of a prescribed amount of acetic acid has an improving effect on "behavioral changes." Specifically, in the "premenstrual" period, the MDQ method found that the mean value for the item "Loss of perseverance in work or study" in the "behavioral changes" domain was significantly reduced from baseline in the "test food intake (second time)" compared to the "test food intake (first time)" (a 9.1% decrease). Therefore, when a prescribed amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the item "Loss of perseverance in work or study" in the "behavioral changes" domain was enhanced by continued intake. This also indicates that the continuous intake of a prescribed amount of acetic acid has an improving effect on "behavioral changes." Specifically, in the "premenstrual" period, the MDQ method found that the mean value for the item "Loss of perseverance in work or study" in the "behavioral changes" domain was significantly reduced from baseline in the "test food intake (second time)" (a 10% trend). That is, in the "premenstrual" period, the MDQ method showed a greater effect of reducing the mean value from baseline in the "behavioral change" category of "decreased work or study efficiency" with "test meal intake (second time)" than with "test meal intake (first time)" (a reduction of 18.2%). Therefore, when a prescribed amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "behavioral change" category of "decreased work or study efficiency" was found to be enhanced by continued intake. Furthermore, this demonstrates the improvement effect of the prescribed amount of acetic acid on "behavioral change." That is, in the "premenstrual" period, the MDQ method showed a greater effect of reducing the mean value from baseline in the "behavioral change" category of "becoming lazy" with "test meal intake (second time)" than with "test meal intake (first time)" (a reduction of 22.2%).Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhanced the improvement effect of the item "becoming lazy" in the "behavioral change" domain. This also confirmed the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "behavioral change." That is, in the "premenstrual" period, the MDQ method showed that the average value of the item "wanting to avoid social interactions" in the "behavioral change" domain was reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a 50% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhanced the improvement effect of the item "wanting to avoid social interactions" in the "behavioral change" domain. This also confirmed the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "behavioral change." That is, "before menstruation," in the "total" item in the "autonomic nervous system disorder" domain, the MDQ method showed a significant effect of decreasing the mean value from baseline when "test meal intake (first time)" was used (5% significant difference). That is, "before menstruation," in the "hot face" item in the "autonomic nervous system disorder" domain, the MDQ method showed a significant effect of decreasing the mean value from baseline when "test meal intake (first time)" was used (5% significant difference). That is, "before menstruation," in the "dizziness" item in the "autonomic nervous system disorder" domain, the MDQ method showed a significant effect of decreasing the mean value from baseline when "test meal intake (second time)" was used (reduction rate 66.7%) compared to when "test meal intake (first time)" was used. Therefore, it was found that when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the item "dizziness" in the "autonomic nervous system imbalance" category is enhanced by the continuous intake. This also shows that the improvement effect of the continuous intake of a predetermined amount of acetic acid is observed in "autonomic nervous system imbalance."That is, in the "premenstrual" period, the MDQ method showed a significant effect of decreasing the mean value from baseline in the "total" category in the "water retention" domain for "test meal intake (first session)" (5% significant difference). That is, in the "premenstrual" period, the MDQ method showed a significant effect of decreasing the mean value from baseline in the "total" category in the "water retention" domain for "test meal intake (second session)" (5% significant difference). That is, in the "premenstrual" period, the MDQ method showed a significant effect of decreasing the mean value from baseline in the "total" category for "test meal intake (second session)" compared to "test meal intake (first session)" (10.9% reduction). Therefore, it was found that when a predetermined amount of acetic acid is taken daily (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), continued intake enhances the improvement effect in the "total" category in the "water retention" domain. Furthermore, this result indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "water retention." Specifically, in the "premenstrual" period, the MDQ method showed a significant decrease in the mean value from baseline for the "skin roughness" category in the "water retention" domain with "test meal intake (second time)" (5% significant difference). Specifically, in the "premenstrual" period, the MDQ method showed a significant decrease in the mean value from baseline for the "skin roughness" category in the "water retention" domain with "test meal intake (second time)" compared to the "test meal intake (first time)" (22.2% decrease). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "skin roughness" category in the "water retention" domain is enhanced by the continuous intake. This also indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "water retention." That is, in the "premenstrual" period, in the "water retention" domain of the MDQ method, for the item "swelling (abdomen, breasts, legs, etc.)", a significant decrease in the average value compared to baseline was observed for "test meal intake (second time)" (5% significant difference).That is, in the "premenstrual" period, in the MDQ method, in the item "Swelling (abdomen, breasts, legs, etc.)" in the "water retention" domain, the average value was found to be significantly reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a 19% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously ingested (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the item "Swelling (abdomen, breasts, legs, etc.)" in the "water retention" domain was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "water retention." That is, in the "premenstrual" period, in the item "weight gain" in the "water retention" domain, the average value was found to be significantly reduced from baseline in the "test meal intake (second time)" (a 5% significant difference). That is, in the "premenstrual" period, in the MDQ method, in the "weight gain" item in the "water retention" domain, the mean value was found to be significantly reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a 12.5% ​​reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously ingested (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "weight gain" item in the "water retention" domain was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "water retention." That is, in the "premenstrual" period, in the "total" item in the "negative emotion" domain, the mean value was found to be significantly reduced from baseline in the "test meal intake (first time)" item (a 5% significant difference). That is, in the "premenstrual" period, in the "negative emotions" domain of the MDQ method, the average value for the "feeling like crying" item was found to be significantly reduced compared to baseline in the "test food intake (first time)" group (5% significant difference).Specifically, during the premenstrual period, the MDQ method demonstrated a significant decrease in the mean value of the "anxious" item in the "negative affect" domain when the test meal was ingested (first time) compared to baseline (5% significant difference). During the premenstrual period, the MDQ method demonstrated a significant decrease in the mean value of the "lonely" item in the "negative affect" domain when the test meal was ingested (first time) compared to baseline (5% significant difference). During the premenstrual period, the MDQ method demonstrated a significant decrease in the mean value of the "upset" item in the "negative affect" domain when the test meal was ingested (second time) compared to when the test meal was ingested (first time) (33.3% decrease). Therefore, it was found that continuous intake of a predetermined amount of acetic acid per day (e.g., 700 mg per day or 735 mg per day) (for at least one menstrual cycle or more, or for at least one month) enhanced the improvement of the "upset" item in the "negative affect" domain. Furthermore, this result indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "negative emotions." Specifically, in the "premenstrual" period, the MDQ method showed a significant decrease in the mean value of the "feeling depressed" item in the "negative emotions" domain for those who "consumed the test meal (second time)" (5% significant difference). Specifically, in the "premenstrual" period, the MDQ method showed a significant decrease in the mean value of the "feeling depressed" item in the "negative emotions" domain for those who "consumed the test meal (second time)" compared with those who "consumed the test meal (first time)" (45.5% decrease). Therefore, it was found that when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "feeling depressed" item in the "negative emotions" domain is enhanced by the continuous intake. This also indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "negative emotions." That is, in the "premenstrual" period, in the "Total" item in the "Mood Elevation" domain of the MDQ method, a significant decrease in the mean value compared to baseline was observed for "test meal intake (second time)" (5% significant difference).That is, in the "premenstrual" period, in the "total" item in the "mood elevation" domain of the MDQ method, the average value was found to be significantly lower than that of the "test meal intake (first time)" (a decrease of 13.6%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "total" item in the "mood elevation" domain was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "mood elevation." That is, in the "premenstrual" period, in the "excitable" item in the "mood elevation" domain of the MDQ method, the average value was found to be significantly lower than that of the baseline (a 10% tendency) in the "test meal intake (second time)" item. That is, in the "premenstrual" period, in the MDQ method, in the "excitable" category in the "mood elevation" domain, the mean value was found to be reduced from baseline by 80% in the "test meal intake (second time)" compared to the "test meal intake (first time)" category. Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "excitable" category in the "mood elevation" domain was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "mood elevation." That is, in the "premenstrual" period, in the MDQ method, the mean value was found to be significantly reduced from baseline by 10% in the "test meal intake (first time)" category in the "mood elevation" domain. That is, "before menstruation," in the "mood elevation" domain of the MDQ method, the average value for the "becoming obedient" item in the "mood elevation" domain was significantly reduced from baseline in the "test meal intake (second time)" category (10% trend). That is, "before menstruation," in the "mood elevation" domain of the MDQ method, the average value for the "test meal intake (second time)" item was significantly reduced from baseline in the "test meal intake (first time)" category (35.7% reduction).Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhanced the improvement effect of the "becoming more obedient" item in the "mood elevation" area. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "mood elevation." That is, in the "premenstrual" period, in the "total" item in the "control" area of ​​the MDQ method, the average value was found to decrease from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a decrease rate of 80%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake enhanced the improvement effect of the "total" item in the "control" area. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to the "control." That is, in the "premenstrual" period, the MDQ method showed that the average value of the "tinnitus" item in the "control" area was reduced by 66.7% (reduction rate) when the "test meal was ingested (second time)" was compared to the "test meal was ingested (first time)" in the "control" area. Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously ingested (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "tinnitus" item in the "control" area was enhanced by continued ingestion. Furthermore, this shows that the improvement effect of continuous ingestion of a predetermined amount of acetic acid was observed in the "control". That is, in the "premenstrual" period, the MDQ method showed that the average value of the "shortness of breath" item in the "control" area was reduced by 100% (reduction rate) when the "test meal was ingested (second time)" was compared to the "test meal was ingested (first time)". Therefore, it was found that when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect on the "shortness of breath" item in the "control" area is enhanced by continued intake.Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on the "control" category. That is, in the "premenstrual" period, the MDQ method showed that the average value of the "chest tightness" item in the "control" category was reduced from baseline by 66.7% in the "test meal intake (second time)" compared to the "test meal intake (first time)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "chest tightness" item in the "control" category was enhanced by continued intake. Also, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on the "control." That is, in the "premenstrual" period, the MDQ method showed that the average value of the "chest tightness" item in the "control" category was reduced from baseline by 100% in the "test meal intake (second time)" compared to the "test meal intake (first time)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "numbness in hands and feet" item in the "control" area. This also confirms the improvement effect of the continuous intake of a predetermined amount of acetic acid for the "control." That is, in the "premenstrual" period, the MDQ method showed that the average value for the "palpitations" item in the "control" area was reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (reduction rate: 100%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "palpitations" item in the "control" area. This also confirms the improvement effect of the continuous intake of a predetermined amount of acetic acid for the "control."Specifically, in the "premenstrual" period, the MDQ method showed a significant decrease in the mean value from baseline for the "total" item in the "PMS" domain for "test meal intake (first session)" (5% significant difference). In other words, in the "premenstrual" period, the MDQ method showed a significant decrease in the mean value from baseline for "test meal intake (second session)" (5% significant difference). In other words, in the "premenstrual" period, the MDQ method showed a greater decrease in the mean value from baseline for "test meal intake (second session)" than for "test meal intake (first session)" (23.2% decrease). Therefore, it was found that when a predetermined amount of acetic acid is taken daily (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), continued intake enhances the improvement effect on the "total" item in the "PMS" domain. This also confirms the improvement effect of continuous intake of a prescribed amount of acetic acid on "PMS." Specifically, in the "premenstrual" period, the MDQ method showed a significant reduction in the mean value from baseline for the "abdominal bloating" category in the "PMS" domain with "test meal intake (second time)" compared to "test meal intake (first time)" (a 33.3% decrease). Therefore, when a prescribed amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "abdominal bloating" category in the "PMS" domain is enhanced by continuous intake. This also confirms the improvement effect of continuous intake of a prescribed amount of acetic acid on "PMS." Specifically, in the "premenstrual" period, the MDQ method showed a significant reduction in the mean value from baseline for the "test meal intake (second time)" category in the "PMS" domain with "irritability, quarrels with close friends, sometimes harshly scolding children" category (a 10% trend).That is, in the "premenstrual" period, the MDQ method found that the mean value for the "irritability, quarrels with close friends, and sometimes harshly scolding children" item in the "PMS" domain was significantly reduced from baseline in the "test meal intake (second session)" compared to the "test meal intake (first session)" (a 14.3% decrease). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the continued intake of acetic acid enhanced the improvement effect in the "PMS" domain item "irritability, quarrels with close friends, and sometimes harshly scolding children." This also confirmed the improvement effect of the continuous intake of a predetermined amount of acetic acid on "PMS." That is, in the "premenstrual" period, the MDQ method found that the mean value for the "changes in appetite" item in the "PMS" domain was significantly reduced from baseline in the "test meal intake (first session)" (a 10% trend). Specifically, in the "premenstrual" period, the MDQ method demonstrated a significant reduction in the mean value from baseline for the "change in appetite" category in the "PMS" domain for those with "test meal intake (second session)" (5% significant difference). Specifically, in the "premenstrual" period, the MDQ method demonstrated a significant reduction in the mean value from baseline for those with "test meal intake (second session)" compared to those with "test meal intake (first session)" (27.8% reduction). Therefore, it was found that continuous intake of a prescribed amount of acetic acid per day (e.g., 700 mg per day or 735 mg per day) (for at least one menstrual cycle or more, or for at least one month) enhanced the improvement effect of the "change in appetite" category in the "PMS" domain. Furthermore, this demonstrates the improvement effect of continuous intake of a prescribed amount of acetic acid on "PMS." That is, in the "premenstrual" period, in the MDQ method, for the item "Loss of confidence, blaming oneself" in the "PMS" domain, the effect of "test meal intake (second time)" being greater than "test meal intake (first time)" was observed to be a decrease in the average value from baseline (reduction rate 42.9%).Therefore, when a predetermined amount of acetic acid (e.g., 700 mg / day or 735 mg / day) is continuously taken (for at least one menstrual cycle or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "Loss of confidence, self-blame" item in the "PMS" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "PMS." Specifically, in the "premenstrual" period, the MDQ method showed a significant reduction in the mean value from baseline for the "constipated" item in the "other" domain for those who "consumed test food (second time)" (5% significant difference). Specifically, in the "premenstrual" period, the MDQ method showed a significant reduction in the mean value from baseline for those who "consumed test food (second time)" compared to those who "consumed test food (first time)" (25% reduction). Therefore, it was found that when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the "constipation" item in the "other" category is enhanced by the continuous intake. This also shows that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "other" menstrual symptoms.

[0144]

[0145] <Changes in menstrual pain and menstrual symptoms before menstruation (in women in their 20s)> The results are shown in Table 9. That is, in the "premenstrual period (in women in their 20s)," in the item "menstrual pain," the VAS method showed a greater effect of reducing the average value from baseline in the "test food intake (second time)" compared to the "test food intake (first time)" (reduction rate: 14.7%). Therefore, it was found that when a predetermined amount of acetic acid per day (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect in the item "menstrual pain" is enhanced by continued intake. That is, in the "premenstrual period (in women in their 20s)," in the item "menstrual pain (change)," the VAS method showed a greater effect of reducing the average value from baseline in the "test food intake (second time)" compared to the "test food intake (first time)" (reduction rate: 101.2%). Therefore, it was found that when a predetermined amount of acetic acid per day (for example, 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or for at least one month), the improvement effect in the category of "menstrual pain (change)" is enhanced by continued intake. That is, in the "premenstrual period (20s)," the MDQ method showed a significant decrease in the mean value from baseline in the category of "total of all MDQ items" for "test meal intake (first time)" (10% trend). That is, an improvement effect of acetic acid intake is observed for all menstrual symptoms and all menstrual-associated symptoms. That is, in the "premenstrual period (20s)," the MDQ method showed a significant decrease in the mean value from baseline in the category of "total of all MDQ items" for "test meal intake (second time)" (10% trend). That is, an improvement effect of acetic acid intake is observed for all menstrual symptoms and all menstrual-associated symptoms. That is, in "premenstrual period (20s)", in the "total" item in the "pain" domain using the MDQ method, the effect of "test meal intake (2nd time)" being greater than "test meal intake (1st time)" in reducing the average value from baseline (reduction rate 7.7%).Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect in the "total" category in the "pain" domain. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "pain." Specifically, in "premenstrual period (20s)," the MDQ method showed that the mean value for the "lower abdominal pain" category in the "pain" domain was reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" category (a reduction rate of 14.3%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhances the improvement effect in the "lower abdominal pain" category in the "pain" domain. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "pain." That is, in "premenstrual period (20s)," in the MDQ method, in the "headache" category in the "pain" domain, the average value was found to be lower from baseline when "test meal intake (2nd time)" was compared to "test meal intake (1st time)" (reduction rate: 33.3%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "headache" category in the "pain" domain was found to be enhanced by continued intake. Furthermore, this indicates that the improvement effect of continuous intake of a predetermined amount of acetic acid on "pain" was found. That is, in "premenstrual period (20s)," in the MDQ method, the average value was found to be lower from baseline when "test meal intake (2nd time)" was compared to "test meal intake (1st time)" (reduction rate: 75%). Therefore, it was found that when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect on the item "body pain" in the "pain" area is enhanced by continued intake.This also confirms the improvement effect of continuous intake of a specified amount of acetic acid on "pain." Specifically, in "premenstrual period (20s)," the MDQ method showed a significant decrease in the mean value from baseline for the item "tired easily" in the "pain" domain with "test meal intake (first time)" (10% trend). Specifically, in "premenstrual period (20s)," the MDQ method showed a significant decrease in the mean value from baseline for the item "tired easily" in the "pain" domain with "test meal intake (second time)" (10% trend). Specifically, in "premenstrual period (20s)," the MDQ method showed a significant decrease in the mean value from baseline for the item "decreased ability to concentrate" in the "decreased ability to concentrate" domain with "test meal intake (first time)" (5% significant difference). Specifically, in "premenstrual period (20s)," the MDQ method showed that in the "decreased concentration" domain, the average value for the "can't organize my thoughts" item was reduced from baseline by 20% when "test meal intake (2nd time)" was compared to "test meal intake (1st time)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhanced the improvement effect of the "can't organize my thoughts" item in the "decreased concentration" domain. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "decreased concentration." Specifically, in "premenstrual period (20s)," the MDQ method showed that in the "decreased concentration" domain, the average value for the "can't organize my thoughts" item was reduced from baseline by 33.3% when "test meal intake (2nd time)" was compared to "test meal intake (1st time)." Therefore, it was found that when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the item "I often make mistakes, such as cutting my fingers or breaking dishes" in the "decline in concentration" category is enhanced by the continuous intake. This also shows that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "decline in concentration."Specifically, in the "premenstrual period (20s)," the MDQ method found that the average value for the item "Losing perseverance in work or study" in the "Behavioral change" domain was significantly reduced from baseline when the "test meal was ingested (2nd time)" was compared to when the "test meal was ingested (1st time)" (a 14.3% decrease). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously ingested (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "Losing perseverance in work or study" item in the "Behavioral change" domain was enhanced by continued intake. Furthermore, this finding indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "behavioral change." Specifically, in the "premenstrual period (20s)," the MDQ method found that the average value for the item "Feeling dizzy" in the "autonomic nervous system imbalance" domain was significantly reduced from baseline when the "test meal was ingested (2nd time)" was compared to baseline (a 10% trend). That is, in the "premenstrual period (20s)," the MDQ method showed that in the "dizziness" category in the "autonomic nervous system imbalance" domain, the "test meal intake (2nd time)" had a greater effect of reducing the average value from baseline than the "test meal intake (1st time)" (a 50% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the "dizziness" category in the "autonomic nervous system imbalance" domain was improved by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "autonomic nervous system imbalance." That is, in the "premenstrual period (20s)," the MDQ method showed that in the "total" category in the "water retention" domain, the "test meal intake (1st time)" had a significantly reduced average value from baseline (a 5% significant difference). That is, in the "premenstrual period (in people in their 20s)," the MDQ method showed that in the "total" item in the "water retention" domain, "test meal intake (second time)" significantly reduced the average value compared to baseline (5% significant difference).That is, in "premenstrual period (20s)," in the MDQ method, in the "total" category in the "water retention" domain, the average value was found to be lower compared to baseline in the "test meal intake (2nd time)" than in the "test meal intake (1st time)" (reduction rate: 10.9%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously ingested (for at least one menstrual cycle or more, or for at least one month), the improvement effect in the "total" category in the "water retention" domain was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "water retention." That is, in "premenstrual period (20s)," in the MDQ method, in the "rough skin" category in the "water retention" domain, the average value was found to be lower compared to baseline in the "test meal intake (2nd time)" than in the "test meal intake (1st time)" (reduction rate: 9.1%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "rough skin" item in the "water retention" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "water retention." Specifically, in "premenstrual period (in their 20s)," the MDQ method showed a significant decrease in the mean value from baseline for the "swelling (abdomen, breasts, legs, etc.)" item in the "water retention" domain with "test meal intake (second time)" (10% trend). Specifically, in "premenstrual period (in their 20s)," the MDQ method showed a significant decrease in the mean value from baseline for the "swelling (abdomen, breasts, legs, etc.)" item in the "water retention" domain with "test meal intake (second time)" compared to "test meal intake (first time)" (29.4% decrease). Therefore, it was found that when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the item "Swelling (abdomen, breasts, legs, etc.)" in the "water retention" area is enhanced by continued intake.This also confirms the improvement effect of continuous intake of a specified amount of acetic acid on "water retention." That is, in "premenstrual period (20s)," the MDQ method showed a significant decrease in the mean value from baseline for the "total" item in the "negative emotion" domain when "test meal intake (1st time)" was used (5% significant difference). That is, in "premenstrual period (20s)," the MDQ method showed a significant decrease in the mean value from baseline for the "feeling anxious" item in the "negative emotion" domain when "test meal intake (1st time)" was used (5% significant difference). That is, in "premenstrual period (20s)," the MDQ method showed a significant decrease in the mean value from baseline for the "feeling anxious" item in the "negative emotion" domain when "test meal intake (1st time)" was used (5% significant difference). That is, in the "premenstrual period (20s)," the MDQ method showed that the "irritable" item in the "negative emotion" domain showed a significant reduction in the average value from baseline when the "test meal was ingested (2nd time)" was compared to when the "test meal was ingested (1st time)" (a 25% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously ingested (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid increased the improvement effect on the "irritable" item in the "negative emotion" domain. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "negative emotion." That is, in the "premenstrual period (20s)," the MDQ method showed a significant reduction in the average value from baseline when the "test meal was ingested (2nd time)" was compared to when the "test meal was ingested (2nd time)" was compared to That is, in the "premenstrual period (in people in their 20s)," the MDQ method showed that for the item "feeling depressed" in the "negative emotions" domain, the average value compared to baseline was reduced by 16.7% when "test meal intake (second time)" was compared to "test meal intake (first time)."Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhanced the improvement effect of the "depressed" item in the "negative emotion" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "negative emotion." Specifically, in "premenstrual period (in their 20s)," the MDQ method showed that the average value of the "excitable" item in the "elevated mood" domain was reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a reduction rate of 100%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake enhanced the improvement effect of the "excitable" item in the "elevated mood" domain. Furthermore, this result indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "mood elevation." Specifically, in "premenstrual period (20s)," the MDQ method showed a significant decrease in the mean value of "becoming obedient" in the "mood elevation" domain for those in their "20s" with test meal intake (second intake)" compared to those in their "1st intake" with test meal intake (12.5% ​​decrease) for those in their "20s" with test meal intake (second intake) compared to those in their "1st intake" with test meal intake (12.5% ​​decrease). Therefore, when a predetermined amount of acetic acid is taken daily (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "becoming obedient" item in the "mood elevation" domain is enhanced by continued intake. This also indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "mood elevation." That is, in "premenstrual period (20s)," in the "total" item in the "control" domain of the MDQ method, the effect of "test meal intake (second time)" being greater than "test meal intake (first time)" in decreasing the average value from baseline (reduction rate 71.4%).Therefore, when a predetermined amount of acetic acid per day (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect in the "total" category in the "control" area. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid for the "control." Specifically, in the "premenstrual period (in their 20s)" category, the MDQ method showed a decrease in the mean value from baseline for the "shortness of breath" category in the "control" area for "test meal intake (second time)" compared to "test meal intake (first time)" (reduction rate: 100%). This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid for the "shortness of breath" category in the "control" area. That is, in "premenstrual period (20s)," the MDQ method showed that the average value for the "chest tightness" item in the "control" area was reduced by 66.7% (reduction rate) compared to "test meal intake (1st)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "chest tightness" item in the "control" area was enhanced by continued intake. Furthermore, this shows that the improvement effect of continuous intake of a predetermined amount of acetic acid is observed in "control." That is, in "premenstrual period (20s)," the MDQ method showed that the average value for the "numbness in hands and feet" item in the "control" area was reduced by 100% (reduction rate) compared to "test meal intake (1st)."Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "numbness in hands and feet" item in the "control" area. This also confirms the improvement effect of the continuous intake of a predetermined amount of acetic acid for the "control." That is, in "premenstrual period (20s)," the MDQ method showed that the average value for the "palpitations" item in the "control" area was reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (reduction rate: 100%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "palpitations" item in the "control" area. This also confirms the improvement effect of the continuous intake of a predetermined amount of acetic acid for the "control." Specifically, in the "premenstrual period (20s)" category, the MDQ method showed a greater effect of reducing the mean value from baseline in the "total" category in the "PMS" domain when "test meal intake (2nd time)" was compared to "test meal intake (1st time)" (a reduction of 21.2%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhanced the improvement effect in the "total" category in the "PMS" domain. Furthermore, this demonstrates the improvement effect of continuous intake of a predetermined amount of acetic acid on "PMS." Specifically, in the "premenstrual period (20s)" category, the MDQ method showed a greater effect of reducing the mean value from baseline in the "feeling of abdominal bloating" category in the "PMS" domain when "test meal intake (2nd time)" was compared to "test meal intake (1st time)" (a reduction of 46.2%).Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "abdominal bloating" item in the "PMS" category. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "PMS." Specifically, in "premenstrual period (in their 20s)," the MDQ method showed a significant decrease in the mean value from baseline for the "change in appetite" item in the "PMS" category with "test meal intake (second session)" (5% significant difference). Specifically, in "premenstrual period (in their 20s)," the MDQ method showed a significant decrease in the mean value from baseline for the "change in appetite" item in the "PMS" category with "test meal intake (second session)" compared to "test meal intake (first session)" (33.3% decrease). Therefore, when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg) continuously (for at least one menstrual cycle or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "change in appetite" item in the "PMS" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "PMS." Specifically, in "premenstrual period (20s)," the MDQ method showed a significant reduction in the mean value from baseline for the "loss of confidence, self-blame" item in the "PMS" domain with "test meal intake (2nd time)" (10% trend). Specifically, in "premenstrual period (20s)," the MDQ method showed a significant reduction in the mean value from baseline for the "loss of confidence, self-blame" item in the "PMS" domain with "test meal intake (2nd time)" compared to "test meal intake (1st time)" (50% reduction). Therefore, it was found that when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the item "Loss of confidence, self-blame" in the "PMS" category is enhanced by the continuous intake. This also confirms the improvement effect of the continuous intake of a predetermined amount of acetic acid on "PMS."Specifically, in "premenstrual period (20s)," the MDQ method found that for the item "Changes in food preferences (e.g., obsession with specific foods)" in the "Other" category, a significant decrease in the mean value from baseline was observed for "test meal intake (first session)" (10% trend). Specifically, in "premenstrual period (20s)," the MDQ method found that for the item "Constipation" in the "Other" category, a significant decrease in the mean value from baseline was observed for "test meal intake (second session)" compared to "test meal intake (first session)" (38.5% decrease). Therefore, when a prescribed amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), continued intake significantly improves the "constipation" item in the "Other" category. Furthermore, this finding indicates that continued intake of a prescribed amount of acetic acid is effective in improving "other" menstrual symptoms. That is, in "premenstrual period (20s)," the MDQ method showed that the average value for "loose stomach (slight diarrhea)" in the "other" category was reduced from baseline by 16.7% when "test meal intake (second time)" was compared to "test meal intake (first time)." Therefore, it was found that when a predetermined amount of acetic acid (for example, 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for one month or more), continued intake increased the improvement effect on the "loose stomach (slight diarrhea)" category in the "other" category. Furthermore, this shows that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "other" menstrual symptoms.

[0146]

[0147] <Changes in menstrual pain and menstrual symptoms before menstruation (30s to 40s)> The results are shown in Table 10. That is, in the "premenstrual period (30s to 40s)", in the item "total of all MDQ items", the MDQ method showed a significant effect of reducing the mean value from baseline in the item "test food intake (second time)" (5% significant difference). That is, an improvement effect of acetic acid intake was observed for all menstrual symptoms and all menstrual symptoms. That is, in the "premenstrual period (30s to 40s)", in the item "total of all MDQ items", the MDQ method showed a significant effect of reducing the mean value from baseline in the item "test food intake (second time)" compared to the item "test food intake (first time)" (reduction rate 22.5%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhances the improvement effect on the "MDQ total" items, i.e., on all menstrual symptoms and all menstrual-associated symptoms. Specifically, in "premenstrual period (30s-40s)," the MDQ method showed that the mean value of "lower abdominal pain" in the "pain" domain was reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (75% reduction). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), continuous intake enhances the improvement effect on the "lower abdominal pain" item in the "pain" domain. Furthermore, this demonstrates the improvement effect of continuous intake of a predetermined amount of acetic acid on "pain." That is, in "premenstrual period (30s-40s)," the MDQ method showed that in the "lower back pain" category in the "pain" domain, the average value from baseline was reduced by 20% when "test meal intake (2nd time)" was compared to "test meal intake (1st time)." Therefore, it was found that when a predetermined amount of acetic acid per day (for example, 700 mg per day or 735 mg per day) was taken continuously (for at least one menstrual cycle or more, or for one month or more), continued intake increased the improvement effect on the "lower back pain" category in the "pain" domain.This also confirms the improvement effect of continuous intake of a prescribed amount of acetic acid on "pain." Specifically, in "premenstrual women (30s-40s)," the MDQ method showed that the average value of the "body pain" item in the "pain" domain was reduced from baseline by 50% when "test meal intake (second session)" was compared to "test meal intake (first session)." Therefore, when a prescribed amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of continuous intake on the "body pain" item in the "pain" domain was enhanced. This also confirms the improvement effect of continuous intake of a prescribed amount of acetic acid on "pain." Specifically, in "premenstrual women (30s-40s)," the MDQ method showed that the average value of the "total" item in the "decreased concentration" domain was reduced from baseline by 23.8% when "test meal intake (second session)" was compared to "test meal intake (first session)." Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "total" item in the "decline in concentration" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "decline in concentration." Specifically, in "premenstrual period (30s-40s)," the MDQ method demonstrated a reduction in the mean value from baseline in the "with test meal (second time)" compared to the "with test meal (first time)" (a reduction rate of 33.3%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhances the improvement effect of the "decline in concentration" item in the "decline in concentration" domain. This also indicates that continuous intake of a prescribed amount of acetic acid has an improving effect on the "decline in concentration."Specifically, in "premenstrual period (30s-40s)," the MDQ method found that the average value for the "poor judgment" item in the "decreased concentration" domain was reduced by 33.3% (reduction rate) when "test meal intake (2nd time)" was compared to "test meal intake (1st time)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "poor judgment" item in the "decreased concentration" domain was enhanced by continued intake. Furthermore, this finding indicates that the continuous intake of a predetermined amount of acetic acid is effective in improving "decreased concentration." Specifically, in "premenstrual period (30s-40s)," the MDQ method found that the average value for the "poor judgment" item in the "decreased concentration" domain was reduced by 60% (reduction rate) when "test meal intake (2nd time)" was compared to "test meal intake (1st time)." Therefore, when a predetermined amount of acetic acid is taken daily (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "distraction" item in the "decline in concentration" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "decline in concentration." Specifically, in "premenstrual (30s-40s)" subjects, the MDQ method demonstrated a reduction in the mean value from baseline in the "distraction" item in the "decline in concentration" domain with "test meal intake (second time)" compared to with "test meal intake (first time)" (a 50% reduction). Therefore, when a predetermined amount of acetic acid is taken daily (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhances the improvement effect of the "distraction" item in the "decline in concentration" domain. This also indicates that continuous intake of a prescribed amount of acetic acid has an improving effect on the "decline in concentration."Specifically, in "premenstrual period (30s-40s)," the MDQ method demonstrated a greater reduction in the mean value from baseline for the "total" item in the "behavioral change" domain when "test meal intake (2nd time)" was compared to "test meal intake (1st time)" (a 44% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhanced the improvement effect in the "total" item in the "behavioral change" domain. Furthermore, this demonstrated the improvement effect of the continuous intake of a predetermined amount of acetic acid on "behavioral change." Specifically, in "premenstrual period (30s-40s)," the MDQ method demonstrated a greater reduction in the mean value from baseline for the "test meal intake (2nd time)" than for "test meal intake (1st time)" in the "behavioral change" domain (a 16.7% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg / day or 735 mg / day) is continuously ingested per day (for at least one menstrual cycle or for at least one month), it was found that the continuous intake of acetic acid enhanced the improvement effect of the "dozing off or getting into bed" item in the "behavioral change" domain. Furthermore, this result confirms the improvement effect of the continuous intake of a predetermined amount of acetic acid with regard to "behavioral change." Specifically, in "premenstrual (30s-40s)," the MDQ method showed a significant decrease in the mean value from baseline for the item "decreased work or study efficiency" in the "behavioral change" domain with "test meal intake (2nd time)" (10% trend). Specifically, in "premenstrual (30s-40s)," the MDQ method showed a significant decrease in the mean value from baseline for the item "decreased work or study efficiency" in the "behavioral change" domain with "test meal intake (2nd time)" compared to "test meal intake (1st time)" (40% decrease). Therefore, it was found that when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect on the item "decreased efficiency at work or study" in the "changes in behavior" area is enhanced by continued intake.This also confirms the improvement effect of continuous intake of a specified amount of acetic acid on "behavioral change." That is, in "premenstrual period (30s-40s)," in the MDQ method, in the item "becoming lazy" in the "behavioral change" domain, the average value was found to be reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (reduction rate: 60%). Therefore, when a specified amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of continuous intake on the item "becoming lazy" in the "behavioral change" domain was found to be enhanced. This also confirms the improvement effect of continuous intake of a specified amount of acetic acid on "behavioral change." Specifically, in "premenstrual period (30s-40s)," the MDQ method demonstrated a greater reduction in the mean value from baseline for the item "wanting to avoid social interactions" in the "behavioral change" domain with "test meal intake (2nd time)" than with "test meal intake (1st time)" (a reduction of 100%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the continued intake of acetic acid enhanced the improvement effect on the item "wanting to avoid social interactions" in the "behavioral change" domain. Furthermore, this demonstrates the improvement effect of the continuous intake of a predetermined amount of acetic acid on "behavioral change." Specifically, in "premenstrual period (30s-40s)," the MDQ method demonstrated a greater reduction in the mean value from baseline for the item "feeling dizzy" in the "autonomic nervous system imbalance" domain with "test meal intake (2nd time)" than with "test meal intake (1st time)" (a reduction of 100%). Therefore, it was found that when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the item "dizziness" in the "autonomic nervous system imbalance" category is enhanced by the continuous intake. This also shows that the improvement effect of the continuous intake of a predetermined amount of acetic acid is observed in "autonomic nervous system imbalance."Specifically, in "premenstrual period (30s-40s)," the MDQ method showed a greater reduction in the average value from baseline for the "total" item in the "water retention" domain when "test meal intake (2nd time)" was compared to "test meal intake (1st time)" (a reduction of 11.1%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously ingested (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhanced the improvement effect in the "total" item in the "water retention" domain. Furthermore, this demonstrated the improvement effect of continuous intake of a predetermined amount of acetic acid on "water retention." Specifically, in "premenstrual period (30s-40s)," the MDQ method showed a greater reduction in the average value from baseline for the "rough skin" item in the "water retention" domain when "test meal intake (2nd time)" was compared to "test meal intake (1st time)" (a reduction of 42.9%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "rough skin" item in the "water retention" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "water retention." That is, in "premenstrual period (30s-40s)," the MDQ method showed that the mean value from baseline in the "weight gain" item in the "water retention" domain was reduced by 28.6% in the "test meal intake (second time)" compared to the "test meal intake (first time)." Therefore, it was found that when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), the continuous intake enhances the improvement effect of the "weight gain" item in the "water retention" domain. This also indicates that continuous intake of a prescribed amount of acetic acid has an improving effect on "water retention."Specifically, in the "premenstrual period (30s-40s)" group, the MDQ method demonstrated a greater reduction in the mean value of the "total" item in the "negative emotion" domain with "test meal intake (2nd time)" compared to "test meal intake (1st time)" (a 37% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously ingested (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhanced the improvement effect on the "total" item in the "negative emotion" domain. Furthermore, this demonstrates the improvement effect of the continuous intake of a predetermined amount of acetic acid on "negative emotion." Specifically, in the "premenstrual period (30s-40s)" group, the MDQ method demonstrated a greater reduction in the mean value of the "feeling like crying" item in the "negative emotion" domain with "test meal intake (2nd time)" compared to "test meal intake (1st time)" (a 75% reduction). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "feeling like crying" item in the "negative emotion" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "negative emotion." Specifically, in "premenstrual period (30s-40s)," the MDQ method demonstrated a reduction in the mean value from baseline for the "feeling anxious" item in the "negative emotion" domain with "test meal intake (second time)" compared with the "test meal intake (first time)" (a 75% reduction). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhances the improvement effect of the "feeling anxious" item in the "negative emotion" domain. This also indicates that continuous intake of a prescribed amount of acetic acid has an improving effect on "negative emotions."Specifically, in "premenstrual period (30s-40s)," the MDQ method showed a greater reduction in the mean value of the "mood disturbance" item in the "negative emotion" domain when the test meal was ingested (second time) than when the test meal was ingested (first time) (a 75% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously ingested (for at least one menstrual cycle or more, or for at least one month), the continued intake of acetic acid enhanced the improvement effect of the "mood disturbance" item in the "negative emotion" domain. Furthermore, this demonstrates the improvement effect of the continuous intake of a predetermined amount of acetic acid on "negative emotion." Specifically, in "premenstrual period (30s-40s)," the MDQ method showed a greater reduction in the mean value of the "mood disturbance" item in the "negative emotion" domain when the test meal was ingested (second time) than when the test meal was ingested (first time) (a 80% reduction). Therefore, it was found that when a predetermined amount of acetic acid was taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), the continuous intake enhanced the improvement effect of the "depressed" item in the "negative emotion" domain. Furthermore, this result confirmed the improvement effect of continuous intake of a predetermined amount of acetic acid on "negative emotion." Specifically, in "premenstrual period (30s-40s)," the MDQ method showed a decrease in the mean value from baseline for the "restless" item in the "negative emotion" domain with "test meal intake (second time)" compared with "test meal intake (first time)" (a 25% decrease). Therefore, it was found that when a predetermined amount of acetic acid was taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), the continuous intake enhanced the improvement effect of the "restless" item in the "negative emotion" domain. This also confirms that the continuous intake of a prescribed amount of acetic acid has an improving effect on "negative emotions." Specifically, in "premenstrual period (30s-40s)," in the MDQ method, in the "Total" category in the "Mood Elevation" domain, a significant decrease in the mean value was observed compared to the baseline for "test meal intake (second time)" (5% significant difference).Specifically, in the "premenstrual period (30s-40s)" category, the MDQ method showed a greater reduction in the average value from baseline for the "total" item in the "mood elevation" domain when the "test meal intake (second session)" was compared to the "test meal intake (first session)" (a reduction of 42.9%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously ingested (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhanced the improvement effect in the "total" item in the "mood elevation" domain. Furthermore, this demonstrated the improvement effect of the continuous intake of a predetermined amount of acetic acid on "mood elevation." Specifically, in the "premenstrual period (30s-40s)" category, the MDQ method showed a greater reduction in the average value from baseline for the "excitable" item in the "mood elevation" domain when the "test meal intake (second session)" was compared to the "test meal intake (first session)" (a reduction of 50%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "excitable" item in the "mood elevation" domain. Furthermore, this result confirms the improvement effect of the continuous intake of a predetermined amount of acetic acid with regard to "mood elevation." Specifically, in "premenstrual period (30s-40s)," the MDQ method showed that the mean value for the "feeling gentle" item in the "mood elevation" domain was reduced from baseline by 33.3% in the "test meal intake (first time)" group compared with the "test meal intake (second time)" group. Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "feeling gentle" item in the "mood elevation" domain. This also indicates that continuous intake of a prescribed amount of acetic acid has an improving effect on "elevated mood."Specifically, in the "premenstrual period (30s-40s)" category, the MDQ method showed a greater reduction in the mean value from baseline for the "becoming more open-minded" item in the "mood elevation" domain when the "test meal intake (2nd time)" was compared to the "test meal intake (1st time)" (a reduction of 66.7%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously ingested (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhanced the improvement effect of the "becoming more open-minded" item in the "mood elevation" domain. Furthermore, this demonstrated the improvement effect of the continuous intake of a predetermined amount of acetic acid on "mood elevation." Specifically, in the "premenstrual period (30s-40s)" category, the MDQ method showed a greater reduction in the mean value from baseline for the "test meal intake (2nd time)" item in the "control" domain when the "test meal intake (1st time)" was compared to the "test meal intake (2nd time)" (a reduction of 100%). Therefore, when a predetermined amount of acetic acid per day (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake enhances the improvement effect in the "total" category in the "control" area. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid for the "control." Specifically, in "premenstrual period (30s-40s)," the MDQ method showed that the mean value for the "tinnitus" category in the "control" area was reduced from baseline in the "test meal intake (second time)" category compared to the "test meal intake (first time)" category (a reduction rate of 100%). This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid for the "tinnitus" category in the "control" area.That is, in "premenstrual period (30s-40s)," in the MDQ method, in the "control" category, in the "palpitations" category, the average value was found to be significantly lower than in the "test meal intake (1st time)" category (100% reduction). Therefore, when a predetermined amount of acetic acid (for example, 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "palpitations" category in the "control" category was found to be enhanced by continued intake. Furthermore, this indicates that the improvement effect of continuous intake of a predetermined amount of acetic acid is observed in the "control." That is, in "premenstrual period (30s-40s)," in the "total" category in the MDQ method, in the "PMS" category, in the "test meal intake (2nd time)" category, the average value was found to be significantly lower than in the "baseline" category (10% trend). Specifically, in the "premenstrual period (30s-40s)" group, the MDQ method demonstrated a greater reduction in the mean value from baseline for the "total" item in the "PMS" domain with "test meal intake (2nd time)" than with "test meal intake (1st time)" (a reduction of 26.1%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhances the improvement effect in the "total" item in the "PMS" domain. Furthermore, this demonstrates the improvement effect of continuous intake of a predetermined amount of acetic acid on "PMS." Specifically, in the "premenstrual period (30s-40s)" group, the MDQ method demonstrated a greater reduction in the mean value from baseline for the "test meal intake (2nd time)" than with "test meal intake (1st time)" in the "PMS" domain (a reduction of 20%). Therefore, it was found that when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for one month or more), the improvement effect on the items "irritability, quarrels with close friends, sometimes harshly scolding children" in the "PMS" category is enhanced by continued intake.This also confirms the improvement effect of continuous intake of a prescribed amount of acetic acid on "PMS." Specifically, in "premenstrual period (30s-40s)," the MDQ method showed that in the "PMS" category, "changes in appetite" showed a decrease in the average value from baseline in the "test meal intake (second time)" category compared to the "test meal intake (first time)" category (a 16.7% decrease). Therefore, when a prescribed amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of continuous intake on the "PMS" category, "changes in appetite," was found to be enhanced. This also confirms the improvement effect of continuous intake of a prescribed amount of acetic acid on "PMS." Specifically, in "premenstrual period (30s-40s)," the MDQ method demonstrated a greater reduction in the mean value from baseline for the "Loss of confidence, self-blame" item in the "PMS" domain when the test meal was ingested (second time) than when the test meal was ingested (first time) (a reduction of 33.3%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously ingested (for at least one menstrual cycle or more, or for at least one month), the continued intake of acetic acid enhanced the improvement effect on the "Loss of confidence, self-blame" item in the "PMS" domain. Furthermore, this demonstrates the improvement effect of the continuous intake of a predetermined amount of acetic acid on "PMS." Specifically, in "premenstrual period (30s-40s)," the MDQ method demonstrated a greater reduction in the mean value from baseline for the "Loss of confidence, self-blame" item in the "PMS" domain when the test meal was ingested (second time) than when the test meal was ingested (first time) (a reduction of 100%). Therefore, it was found that when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the item "frequent tears" in the "PMS" category is enhanced by the continuous intake. This also confirms the improvement effect of the continuous intake of a predetermined amount of acetic acid on "PMS."

[0148]

[0149] <Changes in menstrual pain and menstrual symptoms after menstruation (all subjects)> The results are shown in Table 11. That is, in the "after menstruation" category, the VAS method showed a greater effect of reducing the mean value from baseline in the "with test food intake (second time)" category than in the "with test food intake (first time)" category (reduction rate: 64.2%). Therefore, it was found that when a predetermined amount of acetic acid per day (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect in the "menstrual pain" category was enhanced by continued intake. That is, in the "after menstruation" category, the VAS method showed a greater effect of reducing the mean value from baseline in the "with test food intake (second time)" category than in the "with test food intake (first time)" category (reduction rate: 860%). Therefore, when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), it was found that continued intake enhances the improvement effect in the category of "menstrual pain (change)". That is, in the "postmenstrual period", in the "total of all MDQ items" category, the MDQ method showed a significant decrease in the mean value compared to baseline in the "test meal intake (second time)" category (5% significant difference). That is, an improvement effect of acetic acid intake was observed in all menstrual symptoms and all menstrual-associated symptoms. That is, in the "postmenstrual period", in the "total of all MDQ items" category, the MDQ method showed a decrease in the mean value compared to baseline in the "test meal intake (second time)" category compared to the "test meal intake (first time)" category (reduction rate: 22.8%). Therefore, it was found that when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the continuous intake enhances the improvement effect on the "MDQ total of all items," i.e., on all menstrual symptoms and all menstrual-associated symptoms. That is, in the "postmenstrual" period, in the MDQ method, a significant decrease in the mean value was observed (10% tendency) compared to the baseline for the "total" item in the "pain" domain for "test meal intake (second time)."That is, in the "postmenstrual" period, in the "total" item in the "pain" domain, the MDQ method showed a greater reduction in the average value from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a reduction rate of 6.9%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid increases the improvement effect in the "total" item in the "pain" domain. This also shows that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "pain." That is, in the "postmenstrual" period, in the "lower abdominal pain" item in the "pain" domain, the MDQ method showed a greater reduction in the average value from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a reduction rate of 100%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "lower abdominal pain" item in the "pain" domain. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "pain." That is, in the "postmenstrual" period, the MDQ method showed that the average value of the "lower back pain" item in the "pain" domain was reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (reduction rate: 100%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "lower back pain" item in the "pain" domain. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "pain." That is, in the "postmenstrual" period, in the "pain" domain of the MDQ method, the average value for the "body aches" item was found to be more effective in "test meal intake (second time)" than in "test meal intake (first time)" (reduction rate 100%).Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "body pain" item in the "pain" domain. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "pain." That is, in the "postmenstrual" period, the MDQ method showed that the average value of the "stiff neck and shoulders" item in the "pain" domain was reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a reduction rate of 13.3%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "stiff neck and shoulders" item in the "pain" domain. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "pain." That is, in the "postmenstrual" period, in the "total" category of the "decline in concentration" domain, the MDQ method showed a greater reduction in the average value from baseline in the "test meal intake (second time)" than in the "test meal intake (first time)" category (a reduction of 7.1%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously ingested (for at least one menstrual cycle or more, or for at least one month), the improvement effect in the "total" category of the "decline in concentration" domain is enhanced by continued intake. Furthermore, this indicates that the improvement effect of continuous intake of a predetermined amount of acetic acid is observed with regard to "decline in concentration." That is, in the "postmenstrual" period, in the "poor judgment" category of the "decline in concentration" domain, the MDQ method showed a greater reduction in the average value from baseline in the "test meal intake (second time)" than in the "test meal intake (first time)" category (a reduction of 100%). Therefore, it was found that when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect on the item "dull judgment" in the "decreased concentration" area is enhanced by continued intake.Furthermore, this result indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "decline in concentration." That is, "after menstruation," in the MDQ method, in the "decline in concentration" domain, in the "can't organize my thoughts" category, the average value was found to be reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" category (a 50% reduction). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "can't organize my thoughts" category in the "decline in concentration" domain was found to be enhanced by continued intake. Furthermore, this result indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "decline in concentration." That is, in the "postmenstrual" period, in the MDQ method, in the "decline in concentration" domain, the average value for the item "often making mistakes, such as cutting your fingers or breaking dishes," was found to be reduced from baseline by 100% when the "test meal intake (second session)" was compared to the "test meal intake (first session)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the item "often making mistakes, such as cutting your fingers or breaking dishes" in the "decline in concentration" domain was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid is effective in improving "decline in concentration." That is, in the "postmenstrual" period, in the "total" domain of the MDQ method, the average value for the "test meal intake (second session)" was found to be reduced from baseline by 31.3% when the "test meal intake (first session)" was compared to the "test meal intake (first session)." Therefore, when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the "total" item in the "change in behavior" area is found to be enhanced by the continuous intake. This also shows that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "change in behavior."That is, in the "postmenstrual" period, in the MDQ method, in the "behavioral change" domain, in the item "dozing off or getting into bed," the mean value was found to be reduced from baseline by 60% in the "test meal intake (second time)" compared to the "test meal intake (first time)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "dozing off or getting into bed" item in the "behavioral change" domain was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "behavioral change." That is, in the "postmenstrual" period, in the MDQ method, in the item "losing perseverance in work or study" in the "behavioral change" domain, in the "test meal intake (second time)" compared to the "test meal intake (first time)," the mean value was found to be reduced from baseline by 50%. Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhanced the improvement effect of the item "Losing perseverance in work or study" in the "Behavioral Change" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "behavioral change." That is, in the "postmenstrual" period, the MDQ method demonstrated a reduction in the mean value from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a reduction rate of 50%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhanced the improvement effect of the item "Losing perseverance in work or study" in the "Behavioral Change" domain. This also indicates that continuous intake of a specified amount of acetic acid has an improving effect on "changes in behavior."That is, in the "postmenstrual" period, in the MDQ method, in the "autonomic nervous system imbalance" domain, in the "cold sweat" category, the average value was found to be reduced from baseline by 33.3% in the "test meal intake (second time)" compared to the "test meal intake (first time)" category. Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "cold sweat" category in the "autonomic nervous system imbalance" domain was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "autonomic nervous system imbalance." That is, in the "postmenstrual period," in the MDQ method, in the "total" category in the "water retention" domain, the average value was found to be reduced from baseline by 51.7% in the "test meal intake (second time)" compared to the "test meal intake (first time)" category. Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect in the "total" category in the "water retention" area. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "water retention." That is, in the "postmenstrual" period, the MDQ method showed that the average value for "rough skin" in the "water retention" area was reduced from baseline by 62.5% in the "test meal intake (second time)" compared to the "test meal intake (first time)." This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "water retention." That is, "after menstruation," in the MDQ method, for the item "Swelling (abdomen, breasts, legs, etc.)" in the "water retention" domain, the effect of "test meal intake (second time)" being greater than "test meal intake (first time)" was observed to be a reduction in the average value from baseline (reduction rate 38.5%).Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the item "Swelling (abdomen, breasts, legs, etc.)" in the "Water Retention" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "water retention." That is, in the "postmenstrual" period, in the MDQ method, in the "weight gain" category in the "water retention" domain, the average value was found to decrease from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (decrease rate: 62.5%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake enhances the improvement effect of the item "weight gain" in the "water retention" domain. This also confirms the improvement effect of continuous intake of a prescribed amount of acetic acid on "water retention." Specifically, in the "postmenstrual" period, the MDQ method showed a decrease in the mean value of the "total" item in the "negative emotion" domain for those with "test meal intake (second session)" compared to those with "test meal intake (first session)" (a decrease of 42.9%). Therefore, when a prescribed amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of continuous intake on the "total" item in the "negative emotion" domain is enhanced. This also confirms the improvement effect of continuous intake of a prescribed amount of acetic acid on "negative emotion." Specifically, in the "postmenstrual" period, the MDQ method showed a decrease in the mean value of the "feeling lonely" item in the "negative emotion" domain for those with "test meal intake (second session)" compared to those with "test meal intake (first session)" (a decrease of 100%).Therefore, when a predetermined amount of acetic acid (e.g., 700 mg / day or 735 mg / day) is continuously taken (for at least one menstrual cycle or for at least one month), it was found that the continuous intake of acetic acid enhanced the improvement effect of the "feeling lonely" item in the "negative emotion" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid on "negative emotion." Specifically, in the "postmenstrual" period, the MDQ method showed a significant decrease in the mean value of the "feeling depressed" item in the "negative emotion" domain with "test meal intake (second time)" compared to "test meal intake (first time)" (a 100% decrease). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhanced the improvement effect of the "feeling depressed" item in the "negative emotion" domain. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "negative emotion." That is, in the "postmenstrual" period, the MDQ method showed that the mean value for the "easily tense" item in the "negative emotion" domain was reduced by 66.7% in the "test meal intake (second time)" compared to the "test meal intake (first time)" item. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with respect to "negative emotion." That is, in the "postmenstrual" period, in the "restlessness" item in the "negative emotions" domain using the MDQ method, the average value compared to baseline was found to be lower in the "test meal intake (second time)" than in the "test meal intake (first time)" category (reduction rate 33.3%).Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhanced the improvement effect of the "restless" item in the "negative emotion" domain. This also confirmed the improvement effect of the continuous intake of a predetermined amount of acetic acid with respect to "negative emotion." That is, in the "postmenstrual" period, in the "total" item in the "elevated mood" domain, the MDQ method showed a decrease in the mean value from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a decrease rate of 16.9%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhanced the improvement effect of the "total" item in the "elevated mood" domain. This also confirmed the improvement effect of the continuous intake of a predetermined amount of acetic acid with respect to "elevated mood." That is, in the "mood elevation" domain of the MDQ method, the average value of "excitable" in the "mood elevation" domain was found to be reduced from baseline by 50% in the "test meal intake (second session)" compared to the "test meal intake (first session)" category. Therefore, it was found that when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "excitable" domain in the "mood elevation" domain was enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "mood elevation." That is, in the "mood elevation" domain of the MDQ method, the average value of "excitable" in the "test meal intake (second session)" was found to be reduced from baseline by 22.7% compared to the "test meal intake (first session)" category. Therefore, it was found that when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the item "becoming active" in the "mood enhancement" area is enhanced by continued intake.Furthermore, this result indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "mood elevation." Specifically, in the "postmenstrual" period, the MDQ method showed a significant decrease in the mean value from baseline for the "feeling happy" item in the "mood elevation" domain for those who "consumed the test meal (second time)" (10% trend). Specifically, in the "postmenstrual" period, the MDQ method showed a significant decrease in the mean value from baseline for those who "consumed the test meal (second time)" compared with those who "consumed the test meal (first time)" (22.2% decrease). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "feeling happy" item in the "mood elevation" domain is enhanced by continued intake. This also indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "mood elevation." That is, in the "mood elevation" domain of the MDQ method, in the "mood elevation" domain, the average value for "test meal intake (second session)" was found to be lower than that for "test meal intake (first session)" (a reduction of 15.8%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "mood elevation" domain was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "mood elevation." That is, in the "mood elevation" domain of the MDQ method, in the "total" domain of the "control" domain, in the "postmenstrual" domain, the average value for "test meal intake (second session)" was found to be lower than that for "test meal intake (first session)" (a reduction of 75%). Therefore, when acetic acid is taken in a predetermined amount per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), it was found that the improvement effect in the "Total" item in the "Control" area increases with continued intake.Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on the "control." That is, in the "postmenstrual" period, in the item "numbness in hands and feet" in the "control" area of ​​the MDQ method, the average value was found to be reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a reduction of 100%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "numbness in hands and feet" item in the "control" area was found to be enhanced by continued intake. Also, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on the "control." That is, in the "postmenstrual period," in the item "blurred vision or blindness in some areas" in the "control" area of ​​the MDQ method, the average value was found to be reduced from baseline in the "test meal intake (second time)" compared to the "test meal intake (first time)" (a reduction of 100%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the item "Blurred vision or some areas of vision are unclear" in the "control" area. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid for the "control" category. That is, in the "postmenstrual" period, the MDQ method showed that the average value for the "palpitations" item in the "control" category was reduced from baseline by 100% in the "test meal intake (second time)" compared to the "test meal intake (first time)." This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid for the "palpitations" item in the "control" category.That is, in the "postmenstrual" period, in the "total" item in the "PMS" domain, the MDQ method showed a greater effect of reducing the average value from baseline in the "test meal intake (second time)" than in the "test meal intake (first time)" (a reduction rate of 38.1%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhances the improvement effect in the "total" item in the "PMS" domain. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "PMS." That is, in the "postmenstrual" period, in the "PMS" domain, the MDQ method showed a greater effect of reducing the average value from baseline in the "test meal intake (second time)" than in the "test meal intake (first time)" (a reduction rate of 85.7%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "abdominal bloating" item in the "PMS" category. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "PMS." That is, in the "postmenstrual" period, the MDQ method showed that the mean value for the "change in appetite" item in the "PMS" category was reduced from baseline by 36.4% in the "test meal intake (second time)" compared to the "test meal intake (first time)." This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "PMS." That is, in the "postmenstrual" period, in the "Other" category of the MDQ method, for the item "Loose stomach (slightly diarrhea)", the effect of "test meal intake (second time)" being greater than "test meal intake (first time)" was observed to be a reduction in the average value from baseline (reduction rate 50%).Therefore, it was found that when a predetermined amount of acetic acid is taken daily (for example, 700 mg or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect of the item "loose stomach (slight diarrhea)" in the "Other" category is enhanced by the continuous intake. This also shows that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "Other" menstrual symptoms.

[0150]

[0151] <Changes in menstrual pain and menstrual symptoms after menstruation (in women in their 20s)> The results are shown in Table 12. That is, in the "postmenstrual period (in women in their 20s)," in the VAS method, in the item "menstrual pain," the effect of the average value being reduced from baseline was observed in the "test food intake (second time)" compared to the "test food intake (first time)" (reduction rate: 68.9%). Therefore, it was found that when a predetermined amount of acetic acid per day (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect in the item "menstrual pain" is enhanced by continued intake. That is, in the "postmenstrual period (in women in their 20s)," in the VAS method, in the item "menstrual pain (change)," the effect of the average value being reduced from baseline was observed in the "test food intake (second time)" compared to the "test food intake (first time)" (reduction rate: 4200%). Therefore, when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhances the improvement effect in the category of "menstrual pain (change)". That is, in the "postmenstrual period (in people in their 20s)", in the MDQ method, the average value from baseline was reduced in the "test meal intake (second time)" compared to the "test meal intake (first time)" (decrease rate: 17.3%). Therefore, when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhances the improvement effect in the "MDQ total items", i.e., in general, menstrual symptoms and general menstrual-associated symptoms. That is, in "postmenstrual period (20s)," the MDQ method showed that in the "total" category in the "pain" domain, the average value from baseline was reduced more in the "test meal intake (second time)" than in the "test meal intake (first time)" category (reduction rate 18.2%). Therefore, it was found that when a predetermined amount of acetic acid per day (for example, 700 mg per day or 735 mg per day) was taken continuously (for at least one menstrual cycle or more, or for one month or more), the improvement effect in the "total" category in the "pain" domain was enhanced by continued intake.Furthermore, this result indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "pain." That is, in "postmenstrual period (20s)," the MDQ method showed that the average value of "lower abdominal pain" in the "pain" domain was reduced from baseline when "test meal intake (2nd time)" was compared to "test meal intake (1st time)" (a reduction of 100%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "lower abdominal pain" item in the "pain" domain was found to be enhanced by continuous intake. Also, this result indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "pain." That is, in "postmenstrual period (20s)," the MDQ method showed that the average value of "body pain" in the "pain" domain was reduced from baseline when "test meal intake (2nd time)" was compared to "test meal intake (1st time)" (a reduction of 100%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "body pain" item in the "pain" category. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "pain." Specifically, in the "postmenstrual period (in people in their 20s)" category, the MDQ method showed a decrease in the mean value from baseline in the "stiff neck and shoulders" item in the "pain" category with "test meal intake (second time)" compared to the "test meal intake (first time)" (a 10% decrease). This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "pain."That is, in "postmenstrual period (20s)," in the MDQ method, in the item "tired easily" in the "pain" domain, the average value was found to be lower (16.7%) in the "test meal intake (2nd time)" than in the "test meal intake (1st time)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "tired easily" item in the "pain" domain was found to be enhanced by continued intake. Furthermore, this indicates that the improvement effect of continuous intake of a predetermined amount of acetic acid on "pain." That is, in "postmenstrual period (20s)," in the MDQ method, in the item "total" in the "decreased concentration" domain, the average value was found to be lower (15.4%) in the "test meal intake (2nd time)" than in the "test meal intake (1st time)." Therefore, when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "total" item in the "decline in concentration" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "decline in concentration." That is, in "postmenstrual period (in people in their 20s)," the MDQ method showed that the average value for "dull judgment" in the "decline in concentration" domain was reduced compared to "with test meal intake (first time)" in "with test meal intake (second time)" (reduction rate: 100%). Therefore, when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhances the improvement effect of "dull judgment" in the "decline in concentration" domain. This also indicates that continuous intake of a prescribed amount of acetic acid has an improving effect on the "decline in concentration."That is, in the "postmenstrual period (20s)," in the MDQ method, in the "decline in concentration" domain, the average value was found to be lower (50%) in the "test meal intake (2nd time)" than in the "test meal intake (1st time)" domain for the "inability to concentrate." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "inability to concentrate" domain was found to be enhanced by continued intake. Furthermore, this indicates that the improvement effect of continuous intake of a predetermined amount of acetic acid on "decline in concentration." That is, in the "postmenstrual period (20s)," in the MDQ method, the average value was found to be lower (100%) in the "test meal intake (2nd time)" than in the "test meal intake (1st time)" domain for the "inability to concentrate" domain for the "inability to concentrate." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhanced the improvement effect of the item "I often cut my fingers, break dishes, and make other mistakes" in the "Decreased concentration" domain. Furthermore, this result confirmed the improvement effect of continuous intake of a predetermined amount of acetic acid on "Decreased concentration." That is, in "Postmenstrual period (20s)," the MDQ method showed that the "Total" item in the "Behavioral change" domain showed a decrease in the mean value from baseline in the "Test meal intake (second time)" compared to the "Test meal intake (first time)" (a decrease rate of 38.5%). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhanced the improvement effect of the "Total" item in the "Behavioral change" domain. This also indicates that continuous intake of a specified amount of acetic acid has an improving effect on "changes in behavior."Specifically, in the "postmenstrual period (20s)," the MDQ method showed that the average value for the "dozing off or getting into bed" item in the "behavioral change" domain was reduced by 60% (reduction rate) when the "test meal intake (2nd time)" was compared to the "test meal intake (1st time)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "dozing off or getting into bed" item in the "behavioral change" domain was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "behavioral change." Specifically, in the "postmenstrual period (20s)," the MDQ method showed that the average value for the "loss of perseverance in work or study" item in the "behavioral change" domain was reduced by 33.3% (reduction rate) when the "test meal intake (2nd time)" was compared to the "test meal intake (1st time)." Therefore, when a predetermined amount of acetic acid is taken daily (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhanced the improvement effect of the item "Loss of perseverance at work or study" in the "Behavioral Change" domain. Furthermore, this result confirmed the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "Behavioral Change." That is, in the "Postmenstrual Period (20s)" category, the MDQ method showed that the average value from baseline for the item "Decreased efficiency at work or study" in the "Behavioral Change" domain was reduced by 50% in the "Test Food Intake (First Time)" group compared with the "Test Food Intake (Second Time)" group. Therefore, when a predetermined amount of acetic acid is taken daily (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhanced the improvement effect of the item "Decreased efficiency at work or study" in the "Behavioral Change" domain. This also indicates that continuous intake of a specified amount of acetic acid has an improving effect on "changes in behavior."That is, in the "postmenstrual period (20s)," in the MDQ method, in the "feeling nauseous" category in the "autonomic nervous system imbalance" domain, the average value was found to be reduced from baseline by 50% when "test meal intake (2nd time)" was compared to "test meal intake (1st time)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "feeling nauseous" category in the "autonomic nervous system imbalance" domain was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "autonomic nervous system imbalance." That is, in the "postmenstrual period (20s)," in the MDQ method, in the "total" category in the "water retention" domain, the average value was found to be reduced from baseline by 50% when "test meal intake (2nd time)" was compared to "test meal intake (1st time)." Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect in the "total" category in the "water retention" area. This also confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "water retention." That is, in the "postmenstrual period (in people in their 20s)" category, the MDQ method showed that the average value for "rough skin" in the "water retention" area was reduced compared to "with test meal intake (first time)" in the "with test meal intake (second time)" category (a reduction rate of 66.7%). Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake enhances the improvement effect in the "rough skin" category in the "water retention" area. This also indicates that continuous intake of a prescribed amount of acetic acid has an improving effect on "water retention."That is, in the "postmenstrual period (20s)," in the MDQ method, in the category "Swelling (abdomen, breasts, legs, etc.)" in the "water retention" domain, the average value was found to be reduced from baseline by 30% when "test meal intake (2nd time)" was compared to "test meal intake (1st time)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the category "Swelling (abdomen, breasts, legs, etc.)" in the "water retention" domain was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "water retention." That is, in the "postmenstrual period (20s)," in the MDQ method, in the category "weight gain" in the "water retention" domain, the average value was found to be reduced from baseline by 80% when "test meal intake (2nd time)" was compared to "test meal intake (1st time)." Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "weight gain" item in the "water retention" domain. This also confirms the improvement effect of the continuous intake of a predetermined amount of acetic acid with respect to "water retention." Specifically, in the "postmenstrual period (in the 20s)" category, the MDQ method showed that the mean value for the "total" item in the "negative emotion" domain was reduced by 37.5% compared to the "test meal intake (first time)" category. This also confirms the improvement effect of the continuous intake of a predetermined amount of acetic acid with respect to "negative emotion."That is, in the "postmenstrual period (20s)," the MDQ method showed that the average value of the "feeling lonely" item in the "negative emotion" domain was reduced from baseline by 100% when the "test meal was ingested (second time)" compared to when the "test meal was ingested (first time)." Therefore, it was found that when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously ingested (for at least one menstrual cycle or more, or for at least one month), the continued intake of acetic acid enhanced the improvement effect of the "feeling lonely" item in the "negative emotion" domain. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "negative emotion." That is, in the "postmenstrual period (20s)," the MDQ method showed that the average value of the "feeling upset" item in the "negative emotion" domain was reduced from baseline by 100% when the "test meal was ingested (second time)" compared to when the "test meal was ingested (first time)." Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "mood disturbance" item in the "negative emotion" domain. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid on "negative emotion." That is, in the "postmenstrual period (in people in their 20s)" category, the MDQ method showed that the mean value for the "depressed" item in the "negative emotion" domain was reduced by 100% in the "test meal intake (second time)" category compared to the "test meal intake (first time)" category. Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "depressed" item in the "negative emotion" domain. This also indicates that continuous intake of a prescribed amount of acetic acid has an improving effect on "negative emotions."That is, in the "postmenstrual period (20s)," in the MDQ method, in the "negative emotion" domain, in the "test meal intake (2nd time)" category, the average value was found to be reduced compared to baseline (50% reduction) compared to "test meal intake (1st time)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "negative emotion" domain item "becomes easily tense" was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improvement effect on "negative emotion." That is, in the "postmenstrual period (20s)," in the MDQ method, in the "total" domain in the "elevated mood" domain, in the "test meal intake (1st time)" category, the average value was found to be significantly reduced compared to baseline (10% tendency). That is, in the "postmenstrual period (20s)," in the MDQ method, in the "excitable" category in the "elevated mood" domain, the average value was found to be significantly lower (100%) in the "test meal intake (2nd time)" category than in the "test meal intake (1st time)" category. Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "excitable" category in the "elevated mood" domain was found to be enhanced by continued intake. Furthermore, this indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "elevated mood." That is, in the "postmenstrual period (20s)," in the MDQ method, in the "feeling happy" category in the "elevated mood" domain, the average value was found to be significantly lower (10% trend) in the "test meal intake (1st time)" category. That is, in the "postmenstrual period (in people in their 20s)," the MDQ method showed that in the "elevated mood" domain, the "feeling happy" item, "test food intake (second time)" had a significant effect of decreasing the average value compared to baseline (10% trend).Specifically, in the "postmenstrual period (20s)," the MDQ method found that in the "mood elevation" category, the "feeling gentle" category showed a significant decrease in the mean value compared to baseline for "test meal intake (first session)" (5% significant difference). Specifically, in the "postmenstrual period (20s)," the MDQ method found that in the "total" category in the "control" category, the "test meal intake (second session)" showed a greater decrease in the mean value compared to baseline (66.7% decrease) than the "test meal intake (first session)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously ingested (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhanced the improvement in the "total" category in the "control" category. Furthermore, this finding indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on the "control" category. That is, in the "postmenstrual period (20s)," the MDQ method showed that the average value for the "numbness in hands and feet" item in the "control" area was reduced by 100% in the "test meal intake (second time)" compared to the "test meal intake (first time)" item. Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the "numbness in hands and feet" item in the "control" area was enhanced by continued intake. Furthermore, this shows that the improvement effect of continuous intake of a predetermined amount of acetic acid is observed in the "control." That is, in the "postmenstrual period (20s)," the MDQ method showed that the average value for the "blurred vision or blindness in some areas" item in the "control" area was reduced by 100% in the "test meal intake (second time)" compared to the "test meal intake (first time)" item. Therefore, it was found that when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect on the item "Blurred vision or inability to see in some areas" in the "control" area is enhanced by continued intake.Furthermore, this result indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on the "control" group. Specifically, in the "postmenstrual period (20s)," the MDQ method showed that the average value for the "total" category in the "PMS" domain was reduced from baseline by 46.2% in the "test meal intake (second session)" compared to the "test meal intake (first session)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the continuous intake of acetic acid enhanced the improvement effect on the "total" category in the "PMS" domain. This result also indicates that the continuous intake of a predetermined amount of acetic acid has an improving effect on "PMS." Specifically, in the "postmenstrual period (20s)," the MDQ method showed that the average value for the "feeling of abdominal bloating" category in the "PMS" domain was reduced from baseline by 80% in the "test meal intake (second session)" compared to the "test meal intake (first session)." Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "abdominal bloating" item in the "PMS" category. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "PMS." That is, in the "postmenstrual period (in people in their 20s)" category, the MDQ method showed that the mean value for the "change in appetite" item in the "PMS" category was reduced from baseline by 50% in the "test meal intake (second time)" category compared to the "test meal intake (first time)" category. Therefore, when a predetermined amount of acetic acid is taken per day (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhances the improvement effect of the "change in appetite" item in the "PMS" category. This also indicates that continuous intake of a prescribed amount of acetic acid has an improving effect on PMS.

[0152]

[0153] <Changes in menstrual pain and menstrual symptoms after menstruation (30s to 40s)> The results are shown in Table 13. That is, in the "postmenstrual period (30s to 40s)" group, in the VAS method, in the item "menstrual pain," the effect of the VAS method was observed to be a greater decrease in the mean value from baseline when "test food intake (second time)" was compared to "test food intake (first time)" (reduction rate: 16.7%). Therefore, it was found that when a predetermined amount of acetic acid per day (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect in the item "menstrual pain" was enhanced by continued intake. That is, in the "postmenstrual period (30s to 40s)" group, in the VAS method, the effect of the VAS method was observed to be a greater decrease in the mean value from baseline when "test food intake (second time)" was compared to "test food intake (first time)" (reduction rate: 25%). Therefore, it was found that when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect in the category of "menstrual pain (change)" is enhanced by continued intake. That is, in the category of "total of all MDQ items" in "postmenstrual period (30s-40s)," the MDQ method showed a significant decrease in the mean value from baseline in "test meal intake (second time)" (10% tendency). That is, an improvement effect of acetic acid intake was observed for all menstrual symptoms and all menstrual-associated symptoms. That is, in the category of "postmenstrual period (30s-40s)," the MDQ method showed a significant decrease in the mean value from baseline in "test meal intake (second time)" compared to "test meal intake (first time)" (reduction rate 34.2%). Therefore, it was found that when a predetermined amount of acetic acid is taken per day (for example, 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or for at least one month), the improvement effect on the items in the "MDQ total," i.e., all menstrual symptoms and all menstrual-associated symptoms, is enhanced by continued intake.That is, in "postmenstrual period (30s-40s)," in the MDQ method, in the item "lower back pain" in the "pain" domain, the average value was found to be reduced from baseline by 100% when "test meal intake (2nd time)" was compared to "test meal intake (1st time)." Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the improvement effect of the item "lower back pain" in the "pain" domain was found to be enhanced by continued intake. Furthermore, this indicates that the improvement effect of continuous intake of a predetermined amount of acetic acid on "pain." That is, in "postmenstrual period (30s-40s)," in the MDQ method, the average value was found to be reduced from baseline by 20% when "test meal intake (2nd time)" was compared to "test meal intake (1st time)." Therefore, when a predetermined amount of acetic acid is taken daily (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "stiff neck and shoulders" item in the "pain" category. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid with regard to "pain." That is, in "postmenstrual period (30s-40s)," in the MDQ method, the average value from baseline was reduced in the "test meal intake (second time)" compared to the "test meal intake (first time)" (reduction rate: 100%). Therefore, when a predetermined amount of acetic acid is taken daily (e.g., 700 mg per day or 735 mg per day) continuously (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "loss of perseverance for work or study" item in the "behavioral change" category. This also indicates that continuous intake of a specified amount of acetic acid has an improving effect on "changes in behavior."Specifically, in the "postmenstrual period (30s-40s)" category, the MDQ method demonstrated a greater reduction in the mean value from baseline for the "want to avoid social interactions" category in the "behavioral change" category with "test meal intake (2nd time)" than with "test meal intake (1st time)" (a 100% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) was continuously taken (for at least one menstrual cycle or more, or for at least one month), the continued intake of acetic acid enhanced the improvement effect on the "want to avoid social interactions" category in the "behavioral change" category. Furthermore, this demonstrates the improvement effect of the continuous intake of a predetermined amount of acetic acid on "behavioral change." Specifically, in the "postmenstrual period (30s-40s)" category, the MDQ method demonstrated a greater reduction in the mean value from baseline for the "want to avoid social interactions" category in the "autonomic nervous system imbalance" category with "test meal intake (2nd time)" than with "test meal intake (1st time)" (a 50% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that the continuous intake of acetic acid enhances the improvement effect of the "hot flush" item in the "autonomic nervous system disorder" category. Furthermore, this result confirms the improvement effect of continuous intake of a predetermined amount of acetic acid on "autonomic nervous system disorder." Specifically, in the "postmenstrual period (30s-40s)" category, the MDQ method demonstrated a reduction in the mean value from baseline in the "with test meal (second time)" category compared to the "with test meal (first time)" category (a 50% reduction). Therefore, when a predetermined amount of acetic acid (e.g., 700 mg per day or 735 mg per day) is continuously taken (for at least one menstrual cycle or more, or for at least one month), it was found that continuous intake enhances the improvement effect of the "with cold sweat" item in the "autonomic nervous system disorder" category. This also indicates ...

Claims

A composition for alleviating menstrual pain and / or menstrual symptoms, characterized by containing vinegar. 　 A composition for alleviating menstrual pain and / or symptoms associated with menstruation, characterized by containing vinegar.

3. The composition according to claim 2, wherein the area of ​​menstrual symptoms is one or more of pain, negative emotions, PMS, and water retention. 　 The composition according to claim 3, wherein the items classified into the pain area are one or more of "lower back pain" and "easy fatigue." 　 4. The composition according to claim 3, wherein the item classified in the negative emotion domain is "feeling depressed." 　 4. The composition according to claim 3, wherein the item classified in the PMS domain is "loss of confidence, self-blame." 　 The composition according to claim 3, wherein the item classified into the area of ​​water retention is "swelling (abdomen, breasts, legs, etc.)." 　 A composition for improving premenstrual symptoms, characterized by containing vinegar. 　 The composition according to claim 8, wherein the menstrual symptoms are one or more of the following: pain, autonomic nervous system imbalance, water retention, negative emotions, PMS, other, behavioral changes, and elevated mood. 　 The composition according to claim 9, wherein the item classified in the pain area is "tired easily." 　 The composition according to claim 9, wherein the item classified into the area of ​​autonomic nervous system imbalance is "hot flush of face." 　 The composition according to claim 9, wherein the items classified into the area of ​​water retention are one or more of the following: "rough skin," "swelling (abdomen, breasts, legs, etc.)," ​​and "weight gain." 　 The composition according to claim 9, wherein the items classified into the negative emotion domain are one or more of the following: "feeling like crying," "feeling anxious," "feeling lonely," and "feeling depressed." 　 The composition according to claim 9, wherein the item classified in the other category is "constipation." 　 10. The composition according to claim 9, wherein the item classified in the area of ​​behavioral changes is "decreased efficiency at work or study." 　 The composition according to claim 9, wherein the items classified into the area of ​​mood enhancement are one or more of "becoming more active" and "becoming more obedient." 　 A composition for improving temporary premenstrual "sleeplessness" symptoms, characterized by containing vinegar. 　 A composition for improving menstrual symptoms after menstruation, characterized by containing vinegar.

19. The composition according to claim 18, wherein the area of ​​menstrual symptoms is one or more of negative emotions, pain, and elevated mood.

20. The composition of claim 19, wherein the item classified in the negative emotion domain is "feeling depressed." 　 20. The composition of claim 19, wherein the item classified in the mood enhancement area is "feeling happy." 　 The composition according to claim 1, 2, 8 or 18, wherein the menstrual symptoms are a collective term consisting of the following attributes and items: 　 Pain: lower abdominal pain, lower back pain, headache, body aches, stiff neck and shoulders, fatigue Decreased concentration: Movements become clumsy, concentration decreases, judgment becomes impaired, forgetfulness increases, thoughts become disorganized, sleep becomes difficult, and mistakes such as cutting fingers or breaking dishes occur frequently. Behavioral changes: falling asleep or going to bed, losing perseverance at work or study, decreased work or study efficiency, becoming reluctant to go out, avoiding social interactions Autonomic nervous system imbalance: hot flashes, cold sweats, nausea, dizziness Fluid retention: Breast pain, rough skin, swelling (abdomen, breasts, legs, etc.), weight gain Negative emotions: feeling like crying, feeling anxious, feeling lonely, being irritable, feeling upset, feeling depressed, being easily nervous, feeling restless Elevated mood: Excitable, active, happy, kind, obedient Control: Ringing in the ears, shortness of breath, tightness in the chest, numbness in the limbs, blurred or missing vision, palpitations PMS: Abdominal bloating, irritability, quarrels with close friends, harsh scolding of children, changes in appetite, loss of confidence, self-blame, absence from work, frequent tearfulness, desire to die Other: Changes in food preferences (e.g., obsession with certain foods), constipation, loose bowels (tends to have diarrhea) 　 The composition according to any one of claims 1 to 22, which is a food or drink composition. 　 The composition according to any one of claims 1 to 22, which is a pharmaceutical composition.

20. The composition according to claim 1, 2, 8 or 18, which is formulated so that the daily intake in terms of acetic acid is 700 mg or more.

20. The composition according to claim 1, 2, 8 or 18, which is formulated so that the daily intake is 15 mL or more.

27. The composition according to claim 1, 2, 8, 18, 25 or 26, which is taken continuously for at least one menstrual cycle or for at least one month. The composition according to claim 1, 2, 8 or 18, wherein the vinegar is a fruit vinegar. 　 A composition for improving menstrual pain and / or menstrual symptoms in women in their twenties during menstruation, characterized by containing vinegar. 　 The composition for improvement according to claim 1, which is used to improve menstrual pain and / or menstrual symptoms in women whose menstrual cycles are generally regular. 　 The composition for improvement described in claim 1 is used to improve menstrual pain and / or menstrual symptoms in women aged 20 to 45 who have generally regular menstrual cycles and suffer from menstrual pain during menstruation. 　 On the computer, A function for obtaining a user's menstrual cycle information; a function of estimating a menstrual stage from the menstrual cycle information; a function of acquiring a food containing the composition for improving a menstrual symptom and / or a means for alleviating a menstrual symptom that corresponds to a menstrual symptom specific to the menstrual stage, based on a database storing the composition for improving a menstrual symptom and a recommended means for alleviating the menstrual symptom according to claim 1; a function of predicting the expected improvement degree using a trained model that receives input of a food containing the improving composition and / or the means for alleviating menstrual symptoms and outputs the expected improvement degree of menstrual symptoms; and a function of outputting advice information regarding food containing the improving composition and / or means for alleviating the menstrual symptoms based on the expected improvement degree. program. 　 The program according to claim 32, wherein the advice information is proposed in advance at an appropriate timing that satisfies specified conditions, regarding the foods and / or means for alleviating menstrual symptoms that are expected to alleviate menstrual symptoms in the next or subsequent menstrual stages. 　 The program according to claim 32 , wherein the information regarding symptoms for each menstrual stage includes information regarding symptoms for each menstrual stage of the user. 　 a function of acquiring attribute information relating to attributes of the user; the function of predicting the expected improvement degree predicts the expected improvement degree using a trained model that receives input of the attribute information in addition to the food containing the improving composition and / or the means for alleviating menstrual symptoms, and outputs the expected improvement degree; 33. The program of claim 32.

36. The program according to claim 35, wherein the attribute information is one or more selected from nationality, place of residence, address, gender recognized by the user, and occupation.

36. The program according to claim 35, wherein the attribute information includes information relating to the timing of menarche. 　 acquiring biometric information relating to the user's body; outputting the acquired biometric information and the user's identification information to an information processing unit; 33. The program of claim 32.

39. The program of claim 38, wherein the biometric information includes information regarding the severity of the user's menstrual symptoms. 　 Obtaining the user's eating information; outputting the acquired eating information and the user's identification information to an information processing unit; 33. The program of claim 32. 　 The program according to claim 40, wherein the eating information is eating information estimated from the user's purchasing history.

33. The program of claim 32, wherein the target user comprises a pre-menarcheal user. 　 The program according to claim 32, wherein the advice information is information regarding symptom relief one year or later in the future. 　 The program according to claim 32, wherein the advice information is information relating to the relief of postmenopausal symptoms.

1. A computer-implemented information processing method, comprising: obtaining menstrual cycle information of a user; estimating a menstrual stage from the menstrual cycle information; a step of obtaining a food product containing the menstrual symptom-improving composition and / or a menstrual symptom-relief measure corresponding to the menstrual symptom specific to the menstrual stage based on a database storing the menstrual symptom-improving composition according to claim 1 and a recommended menstrual symptom-relief measure; a step of predicting the expected improvement degree using a trained model that receives input of a food containing the improving composition and / or the means for alleviating menstrual symptoms and outputs the expected improvement degree of menstrual symptoms; and outputting advice information regarding a food product containing the improving composition and / or a means for alleviating the menstrual symptoms based on the expected improvement rate. Information processing methods.

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