Apparatus and method for providing activity for improving psychophysiological response using soil microorganisms

Abstract

Disclosed are an apparatus and method for providing an activity for improving psychophysiological response using soil microorganisms. The method for providing an activity for improving psychophysiological response using soil microorganisms according to an embodiment of the present application may comprise: (a) a step for acquiring design information on a soil environment, inoculated with target microorganisms, in relation to a target activity that a subject performs using the soil environment; (b) a step for collecting biometric data of the subject who participated in the target activity; and (c) a step for generating evaluation information on a psychophysiological response of the subject corresponding to the design information through analysis of the biometric data.

Description

Device and method for providing activities to improve psychophysiological responses using soil microorganisms

[0001] The present invention relates to an apparatus and method for providing activities to improve psychophysiological responses using soil microorganisms. For example, the present invention relates to a technique for alleviating depression by improving the psychophysiological response of a subject through horticultural activities using soil rich in Streptomyces rimosus.

[0002] This invention is a result of the Regional Innovation Center University Support System (RISE) project, which was carried out with funding from the Ministry of Education and the Seoul Metropolitan Government and supported by the Seoul RISE Center in 2025, and a result of the project to elucidate the healing mechanism of physiologically active substances derived from soil microorganisms based on horticultural activities for the mental health of the elderly (Project No. 2710078662), which was carried out with funding from the Ministry of Science and ICT and supported by the National Research Foundation of Korea in 2025.

[0003] Depression is a mental disorder characterized by persistent mood swings, sadness, and dysphoria; according to the World Health Organization, it is considered a common disorder affecting approximately 300 million people. While the pathological mechanisms of depression remain unclear, hypothalamic-pituitary-adrenal axis dysfunction, neurotransmitter dysregulation, and neuroinflammation are considered major factors. In particular, neuroinflammation has emerged as a significant pathology in depression, as many previous studies have reported depression in patients with immune diseases, infectious diseases, or exposure to cytokines. Furthermore, increased cytokine levels caused by neuroinflammation lead to synaptic damage and reduced synaptic plasticity, which is a key target mechanism for drug development.

[0004] In particular, neuroinflammation is a major mechanism of the onset of depression; the inflammatory hypothesis of depression was proposed more than 20 years ago and is still accepted today. Glial cells are cells that regulate inflammation in the central nervous system and become activated during inflammatory states. Activated glial cells secrete various inflammatory cytokines that negatively affect neuronal and synaptic plasticity, and these substances can trigger behaviors associated with depression. Accordingly, there is a growing need for the introduction of therapeutic approaches that can alleviate neuroinflammation and enhance synaptic plasticity to improve depression.

[0005] Meanwhile, horticultural activities are known to provide various psychophysiological effects. Notably, stress reduction is one of the most prominent effects, manifested through a decrease in cortisol levels and an improvement in heart rate variability. Mood improvement is also significant, with the secretion of hormones such as serotonin and dopamine being stimulated, which is observed to reduce depressive symptoms. Furthermore, there is a positive impact on cognitive function; it is known to increase concentration and, in particular, improve short-term memory in dementia patients.

[0006] Gardening activities also provide multisensory stimulation to activate various areas of the brain, enhance overall well-being through the combination of physical activity and mental focus, and can improve sleep quality as exposure to natural light through outdoor gardening promotes melatonin production and regulates circadian rhythms.

[0007] These diverse effects are the result of the complex interplay of various elements of horticultural activities, including physical activity, contact with nature, a sense of accomplishment, and social interaction. Horticultural activities are recognized as an effective and integrated method for promoting overall mental and physiological well-being, and are increasingly being utilized in various therapeutic and well-being programs.

[0008] Meanwhile, as the impact of soil microorganisms used in horticultural activities on the mental health of participants is not precisely known, there is a growing need to objectively evaluate the effectiveness of horticultural activities utilizing soil microorganisms in order to manage mood disorders such as depression through horticultural activities.

[0009] The technology forming the background of the present invention is disclosed in Korean Published Patent Application No. 10-2023-0129265.

[0010]

[0011] The present invention aims to solve the problems of the aforementioned conventional technology by providing an apparatus and method for providing activities to improve psychophysiological responses using soil microorganisms, which can alleviate depression and the like by improving the psychophysiological response of a subject through activities performed using a soil environment inoculated with target microorganisms.

[0012] However, the technical problems that the embodiments of the present invention aim to solve are not limited to the technical problems described above, and other technical problems may exist.

[0013] As a technical means for achieving the above-mentioned technical task, a method for providing an activity for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention may include: (a) obtaining design information regarding a soil environment in relation to a target activity performed by a subject using a soil environment inoculated with target microorganisms; (b) collecting biological data of the subject who participated in the target activity; and (c) generating evaluation information regarding the subject's psychophysiological response corresponding to the design information through analysis of the biological data.

[0014] In addition, a method for providing an activity to improve psychophysiological responses using soil microorganisms according to one embodiment of the present invention may include (d) a step of updating the design information to adjust the soil environment according to the evaluation information.

[0015] Additionally, the above step (c) may include a step of analyzing the behavioral pattern of the subject after participation in the target activity using the biometric data.

[0016] Additionally, the above step (c) may include a step of evaluating the microglia activation status of the subject using the above biological data.

[0017] Additionally, the above step (c) may include a step of evaluating the astrocyte activation status of the subject using the above biological data.

[0018] Additionally, the above step (c) may include a step of evaluating the subject's synaptic plasticity using the above biological data.

[0019] In addition, the target microorganism may include Streptomyces rimosus.

[0020] In addition, the above target activity may include horticultural activities performed in the soil environment.

[0021] Additionally, the above step (d) may include a step of determining additional activities other than the horticultural activities recommended for the subject to participate in, taking into account the above evaluation information.

[0022] Meanwhile, an activity providing device for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention may include an activity design unit that acquires design information regarding a soil environment in relation to a target activity performed by a subject using a soil environment inoculated with target microorganisms, a data collection unit that collects biological data of the subject who participated in the target activity, and a response evaluation unit that generates evaluation information regarding the subject's psychophysiological response corresponding to the design information through analysis of the biological data.

[0023] In addition, the activity design unit may update the design information to adjust the soil environment according to the evaluation information.

[0024] In addition, the response evaluation unit can analyze the behavioral pattern of the subject after participation in the target activity using the biometric data.

[0025] In addition, the above reaction evaluation unit can evaluate the microglia activation status of the subject using the above biological data.

[0026] In addition, the reaction evaluation unit can evaluate the astrocyte activation status of the subject using the biological data.

[0027] In addition, the response evaluation unit can evaluate the synaptic plasticity of the subject using the biological data.

[0028] In addition, the activity design unit may determine additional activities other than the horticultural activities recommended for the subject to participate in, taking into consideration the evaluation information.

[0029] The means for solving the problem described above are merely exemplary and should not be interpreted as intended to limit the present invention. In addition to the exemplary embodiments described above, additional embodiments may exist in the drawings and the detailed description of the invention.

[0030] According to the means for solving the problem of the present invention described above, it is possible to provide a device and method for providing activities to improve psychophysiological responses using soil microorganisms, which can alleviate depression and the like by improving the psychophysiological response of a subject by performing activities using a soil environment inoculated with target microorganisms.

[0031] However, the effects obtainable from this invention are not limited to those described above, and other effects may exist.

[0032] FIG. 1 is a schematic diagram of a psychophysiological response analysis system including an activity providing device for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention.

[0033] FIG. 2 is an experimental example linked to an activity providing device for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention, and is a diagram showing the effect of soil exposure containing S. rimosus on depression-like behavior.

[0034] FIG. 3 is an experimental example linked to an activity providing device for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention, and is a diagram showing the inhibitory effect of soil exposure containing S. rimosus on microglia activation in the brain of a mouse.

[0035] FIG. 4 is an experimental example linked to an activity providing device for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention, and is a diagram showing the inhibitory effect of soil exposure containing S. rimosus on the activation of astrocytes in the brain of a mouse.

[0036] FIG. 5 is an experimental example linked to an activity providing device for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention, and is a diagram showing the effect of soil exposure containing S. rimosus on the reduction of cytokine mRNA expression levels in the brain of a mouse.

[0037] FIG. 6 is an experimental example linked to an activity providing device for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention, showing the synaptic protective effect of soil exposure containing S. rimosus on the CA3 region of the rat hippocampus.

[0038] FIG. 7 is a schematic diagram of an activity providing device for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention.

[0039] FIG. 8 is a flowchart of an operation for a method of providing an activity to improve psychophysiological responses using soil microorganisms according to one embodiment of the present invention.

[0040] Figure 9 is a detailed flowchart of the process for generating evaluation information on the subject's psychophysiological response.

[0041]

[0042] Embodiments of the present invention are described below with reference to the attached drawings to enable those skilled in the art to easily implement the invention. However, the present invention may be embodied in various different forms and is not limited to the embodiments described herein. Furthermore, in order to clearly explain the present invention in the drawings, parts unrelated to the explanation have been omitted, and similar parts throughout the specification are denoted by similar reference numerals.

[0043] Throughout this specification, when a part is described as being "connected" to another part, this includes not only cases where they are "directly connected," but also cases where they are "electrically connected" or "indirectly connected" with other elements interposed between them.

[0044] Throughout the entire specification, when a component is described as being located "on," "on top," "on top," "under," "on bottom," or "on bottom" of another component, this includes not only cases where the component is in contact with the other component but also cases where another component exists between the two components.

[0045] Throughout this specification, when a part is described as "comprising" a certain component, this means that, unless specifically stated otherwise, it does not exclude other components but may include additional components.

[0046] The present invention relates to an apparatus and method for providing activities to improve psychophysiological responses using soil microorganisms. For example, the present invention relates to a technique for alleviating depression by improving the psychophysiological response of a subject through horticultural activities using soil rich in Streptomyces rimosus.

[0047] FIG. 1 is a schematic diagram of a psychophysiological response analysis system including an activity providing device for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention.

[0048] Referring to FIG. 1, in one embodiment of the present invention, a psychophysiological response analysis system (10) may include an activity providing device (100) for improving psychophysiological response using soil microorganisms according to one embodiment of the present invention (hereinafter referred to as 'activity providing device (100)'), a database (200), and a user terminal (300).

[0049] The activity providing device (100), the database (200), and the user terminal (300) can communicate with each other through a network (20). The network (20) refers to a connection structure that enables information exchange between each node, such as terminals and servers. Examples of such a network (20) include, but are not limited to, a 3GPP (3rd Generation Partnership Project) network, an LTE (Long Term Evolution) network, a 5G network, a WIMAX (World Interoperability for Microwave Access) network, the Internet, a LAN (Local Area Network), a Wireless LAN (Wireless Local Area Network), a WAN (Wide Area Network), a PAN (Personal Area Network), a Wi-Fi network, a Bluetooth network, a satellite broadcasting network, an analog broadcasting network, and a DMB (Digital Multimedia Broadcasting) network.

[0050] The user terminal (300) can be any type of wireless communication device, such as a smartphone, smartpad, tablet PC, PCS (Personal Communication System), GSM (Global System for Mobile communication), PDC (Personal Digital Cellular), PHS (Personal Handyphone System), PDA (Personal Digital Assistant), IMT (International Mobile Telecommunication)-2000, CDMA (Code Division Multiple Access)-2000, W-CDMA (W-Code Division Multiple Access), Wibro (Wireless Broadband Internet) terminal.

[0051] Additionally, in the description of the embodiments of the present invention, the database (200) may be a server or device for storing information about target microorganisms used in target activities (e.g., horticultural activities, etc.) (e.g., soil environment, information on volatile organic compounds generated by microorganisms, culture medium information, etc.), horticultural activity design information (e.g., activity type, activity time, etc.), and biological data collected before and after the horticultural activity of a subject participating in the horticultural activity.

[0052] Below, the specific functions and operations of the activity providing device (100) will be described in detail.

[0053] First, the activity providing device (100) can obtain design information regarding the soil environment in relation to the target activity performed by the subject using the soil environment inoculated with the target microorganism.

[0054] For example, a horticultural activity providing device (100) can set Streptomyces rimosus as a target microorganism and obtain horticultural activity design information including information about the inoculation environment of Streptomyces rimosus.

[0055] Additionally, the activity providing device (100) can collect biometric data of a subject who participated in the target activity. For example, the activity providing device (100) can collect the subject's brainwave data and metabolite data obtained using the subject's blood sample.

[0056] In addition, the activity providing device (100) can collect various biometric data to analyze whether depression-related behaviors have decreased depending on the subject's participation in the target activity, as described below.

[0057] For example, an activity providing device (100) can collect physiological indicator data such as heart rate data, heart rate variability data, body temperature data, and skin conductivity data that are continuously measured through a wearable device (not shown) that is worn or attached to the subject's body.

[0058] Additionally, the activity providing device (100) can collect exercise-related data, such as the subject's daily step count, activity intensity, and changes in body posture, based on an accelerometer and a gyroscope sensor using a wearable device (not shown) and / or a user terminal (300).

[0059] As another example, the activity providing device (100) may collect data measuring brain waves (EEG), eye movements (EOG), electromyography (EMG), respiration rate, oxygen saturation, etc. during sleep from a wearable device (not shown) and / or a user terminal (300) to evaluate the quality and pattern of sleep before and after the subject's participation in the target activity.

[0060] As another example, the activity providing device (100) may acquire a blood sample and / or saliva sample of the subject and measure hormone levels such as cortisol and melatonin and inflammatory markers contained in the sample to track biochemical changes. Thus, the activity providing device (100) disclosed herein can operate to accurately analyze overall physiological and behavioral patterns related to the subject's depression-related behavioral patterns through the collection of comprehensive and multifaceted bio-data before and after the subject's participation in the target activity.

[0061] Additionally, the activity providing device (100) can generate evaluation information regarding the subject's psychophysiological response corresponding to the design information through analysis of the acquired bio-data.

[0062] Specifically, the activity providing device (100) can analyze the behavioral pattern of the subject after participation in the target activity using biometric data.

[0063] In this regard, the activity providing device (100) can measure and analyze the subject's daily behavior and psychological state from various angles to analyze the subject's behavioral patterns related to depression-like behavior. Specifically, the subject's subjective depressive symptoms can be quantified based on the Beck Depression Scale and the Hamilton Depression Scale, which are standardized depression assessment scales, and the decrease in activity associated with depression can be objectively evaluated by analyzing daily activity data collected through a wearable device (not shown).

[0064] Additionally, the activity providing device (100) can detect sleep disorders, which are major symptoms of depression, by analyzing the subject's sleep patterns using a sleep tracking app or a sensing module installed on a wearable device (not shown) and / or a user terminal (300). As another example, the activity providing device (100) can track changes in the emotional state by analyzing the subject's facial expressions based on artificial intelligence-based video analysis technology, and can also evaluate depressive symptoms appearing in verbal expressions by detecting changes in voice characteristics related to depression using voice analysis technology. Thus, the activity providing device (100) disclosed herein can more accurately and objectively identify the overall behavioral patterns related to depression-like behaviors of the subject before and after participation in target activities by comprehensively analyzing various data.

[0065] Additionally, the activity providing device (100) can evaluate the microglia activation status of the subject using collected biological data.

[0066] Specifically, the activity providing device (100) can evaluate the state of neuroinflammation by measuring and analyzing the degree of activation of microglia in a brain region in response to the subject's participation in a target activity in various ways. According to one embodiment of the present invention, the activity providing device (100) can directly track inflammatory markers in the brain by using TSPO ligands based on PET scan technology, and can evaluate the state of systemic inflammation by measuring the concentration of biomarkers related to microglia activation, such as GFAP and S100B, using blood analysis technology. In addition, the state of inflammation in the central nervous system can be determined more accurately by measuring the concentration of specific proteins related to microglia activation based on cerebrospinal fluid analysis technology.

[0067] Additionally, the activity providing device (100) can evaluate the subject's astrocyte activation status using collected biodata.

[0068] Specifically, the activity providing device (100) can evaluate the state of neuroinflammation and neurodamage by measuring and analyzing the degree of activation of astrocytes from various angles. According to one embodiment of the present invention, the activity providing device (100) can non-invasively evaluate the degree of activation of astrocytes by measuring the concentration of myo-inositol in the brain based on MRI spectroscopy technology, and can quantitatively determine the inflammatory state of the central nervous system by measuring the concentration of GFAP using blood or cerebrospinal fluid analysis technology. In addition, it can operate to indirectly evaluate the overall state of astrocyte activation of the central nervous system by observing the degree of activation of astrocytes in the retina based on retinal examination technology.

[0069] In addition, according to one embodiment of the present invention, the activity providing device (100) can evaluate the systemic inflammatory state by measuring and analyzing the expression levels of inflammatory cytokines in various ways. According to one embodiment of the present invention, the activity providing device (100) can quantitatively evaluate the systemic inflammatory state by directly measuring the levels of inflammatory cytokines such as IL-6, IFN-γ, and IL-17A of a subject through a blood test, and routine monitoring is possible by non-invasively measuring cytokine levels through a saliva test. In addition, it can operate to indirectly estimate the systemic inflammatory state by evaluating local inflammatory responses based on skin patch test technology.

[0070] Additionally, the activity providing device (100) can evaluate the subject's synaptic plasticity using collected biometric data.

[0071] Specifically, the activity providing device (100) can evaluate the functional state of a neural network by measuring and analyzing changes in synaptic plasticity from various angles. According to one embodiment of the present invention, the activity providing device (100) can monitor changes in synaptic plasticity in real time by analyzing brainwaves, particularly alpha wave activity, based on EEG technology, and can evaluate changes in synaptic plasticity at a large network level by analyzing brain functional connectivity using fMRI technology. In addition, changes in synaptic plasticity can be directly measured by evaluating cortical excitability based on transcranial magnetic stimulation (TMS) technology. Furthermore, the actual effect of improving synaptic plasticity can be confirmed by evaluating working memory, attention, learning ability, etc., using cognitive function test technology, and molecular indicators of neural plasticity can be evaluated by measuring BDNF levels based on blood analysis technology.

[0072] Additionally, the activity providing device (100) can update design information to adjust the soil environment applied to the target activity according to evaluation information derived by evaluating the psychophysiological response of the subject to the target activity participation as described in detail above.

[0073] In this regard, the activity providing device (100) may operate to change design information to adjust the soil environment used in the target activity (e.g., upward adjustment of the target microorganism inoculation level, etc.) or change the content of the target activity (e.g., changing the activity participation cycle, time per participation, and physical activity guided to be performed by the subject to be performed relatively close to the soil, etc.) when it is determined that the effect of improving the subject's depression has been insufficiently achieved based on evaluation information derived after the subject participates in the target activity (e.g., when it is determined that pre-set depression-related behaviors have not been sufficiently reduced, when it is determined that the activation of microglia and / or astrocytes has not been sufficiently suppressed, when it is determined that the mRNA expression level of cytokines in the subject's brain region has not been sufficiently reduced, when it is determined that the synaptic plasticity of the subject's brain region has not been sufficiently improved, etc.).

[0074] In other words, according to one embodiment of the present invention, if the evaluation information derived for a subject after participation in a target activity does not meet a preset target level, the activity providing device (100) can change the design information applied to the target activity or the content of the target activity, and then induce the subject to participate in the target activity again with the changed elements reflected.

[0075] Below, an experimental example linked to an activity providing device (100) will be described with reference to FIGS. 2 to 6.

[0076] This experiment investigated the effects of exposing rat subjects, subjected to a depression model induced by Chronic Restraint Stress (CRS), to soil rich in Streptomyces rimosus (S. rimosus). The experiment involved inducing CRS for 14 days and conducting direct soil exposure for 17 days starting from the first day of CRS induction. The experimental groups were divided into a normal group (NOR), a CRS group, a CRS + sterile soil group, and a CRS + S. rimosus soil group.

[0077] FIG. 2 is an experimental example linked to an activity providing device for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention, and is a diagram showing the effect of soil exposure containing S. rimosus on depression-like behavior.

[0078] Referring to Figure 2, the tail suspension test (TST) and forced swimming test (FST) were performed to evaluate depression-like behaviors, and it was confirmed that the increased floating time due to CRS was significantly reduced in the S. rimosus soil exposure group. On the other hand, no significant change was observed in the sterile soil exposure group.

[0079] FIG. 3 is an experimental example linked to an activity providing device for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention, showing the inhibitory effect of soil exposure containing S. rimosus on microglia activation in a mouse brain, and FIG. 4 is an experimental example linked to an activity providing device for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention, showing the inhibitory effect of soil exposure containing S. rimosus on astrocyte activation in a mouse brain.

[0080] Referring to Figures 3 and 4, in this experimental example, to evaluate the neuroinflammation inhibitory effect, the expression of Iba-1, an activation marker for microglia, and GFAP, an activation marker for astrocytes, was analyzed by immunohistochemistry. Referring to Figures 3 and 4, it can be seen that the area of ​​Iba-1 and GFAP-positive cells in the hippocampal dentate gyrus (DG), cerebral cortex, and paraventricular nucleus (PVN), which were increased due to CRS, was significantly reduced in the S. rimosus soil exposure group. No significant changes were observed in the sterile soil exposure group.

[0081] FIG. 5 is an experimental example linked to an activity providing device for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention, and is a diagram showing the effect of soil exposure containing S. rimosus on the reduction of cytokine mRNA expression levels in the brain of a mouse.

[0082] Referring to Figure 5, real-time PCR was performed to evaluate the expression levels of inflammatory cytokines in this experimental example, and as a result, it was confirmed that the expression levels of IL-6, IFN-γ, and IL-17A mRNA in the hippocampus, cerebral cortex, and hypothalamus, which were increased due to CRS, were significantly reduced in the S. rimosus soil exposure group. In the sterile soil exposure group, only the expression level of IFN-γ in the cerebral cortex was significantly reduced.

[0083] FIG. 6 is an experimental example linked to an activity providing device for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention, showing the synaptic protective effect of soil exposure containing S. rimosus on the CA3 region of the rat hippocampus.

[0084] Referring to Figure 6, in this experimental example, to evaluate the synaptic plasticity regulatory effect, the expression of the postsynaptic marker PSD95 and the presynaptic marker SYP in the hippocampal CA3 region was analyzed by immunohistochemistry. As a result, it was confirmed that the optical densities of PSD95 and SYP, which were reduced due to CRS, significantly increased in the S. rimosus soil exposure group. No significant change was observed in the sterile soil exposure group.

[0085] Taken together, these results suggest that exposure to soil rich in S. rimosus may suppress neuroinflammation and improve synaptic plasticity, thereby alleviating depression-like behaviors. This is presumed to be due to the olfactory stimulation of geosmin and 2-methylisoborneol produced by S. rimosus, and can be interpreted as a result supporting the positive effects of natural soil exposure on mental health.

[0086] FIG. 7 is a schematic diagram of an activity providing device for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention.

[0087] Referring to FIG. 7, the activity providing device (100) may include an activity design unit (110), a data collection unit (120), and a response evaluation unit (130).

[0088] The activity design unit (110) can obtain design information regarding the soil environment in relation to the target activity performed by the subject using the soil environment inoculated with the target microorganism.

[0089] For example, the horticultural activity design unit (110) can set Streptomyces rimosus as a target microorganism and obtain horticultural activity design information including information on the inoculation environment of Streptomyces rimosus.

[0090] Additionally, the activity design unit (110) can update the design information to adjust the soil environment applied to the target activity according to the evaluation information derived by the response evaluation unit (130), described later, evaluating the psychophysiological response of the subject to the target activity participation.

[0091] The data collection unit (120) can collect biological data of a subject who participated in a target activity. For example, the data collection unit (120) can collect the subject's brainwave data and metabolite data obtained using the subject's blood sample.

[0092] In addition, the data collection unit (120) can collect various biometric data to analyze whether depression-related behaviors have decreased in accordance with the subject's participation in target activities, as described below.

[0093] For example, the data collection unit (120) can collect physiological indicator data such as heart rate data, heart rate variability data, body temperature data, and skin conductivity data that are continuously measured through a wearable device (not shown) that is worn or attached to the subject's body.

[0094] Additionally, the data collection unit (120) can collect exercise-related data, such as the subject's daily step count, activity intensity, and changes in body posture, based on an accelerometer and a gyroscope sensor using a wearable device (not shown) and / or a user terminal (300).

[0095] As another example, the data collection unit (120) may collect data measuring brain waves (EEG), eye movements (EOG), electromyography (EMG), respiration rate, oxygen saturation, etc. during sleep from a wearable device (not shown) and / or a user terminal (300) to evaluate the quality and pattern of sleep before and after the subject's participation in the target activity.

[0096] As another example, the data collection unit (120) may acquire a blood sample and / or saliva sample of the subject and measure hormone levels such as cortisol and melatonin and inflammatory indicators contained in the sample to track biochemical changes. Thus, the activity providing device (100) disclosed herein can operate to accurately analyze overall physiological and behavioral patterns related to the subject's depression-related behavioral patterns through the collection of comprehensive and multifaceted bio-data before and after the subject's participation in the target activity.

[0097] The response evaluation unit (130) can generate evaluation information on the subject's psychophysiological response corresponding to the design information through analysis of the acquired bio-data.

[0098] Specifically, the response evaluation unit (130) can analyze the behavioral pattern of the subject after participation in the target activity using biometric data.

[0099] In this regard, the reaction evaluation unit (130) can measure and analyze the subject's daily behavior and psychological state from various angles to analyze the subject's behavioral patterns related to depression-like behavior. Specifically, the subject's subjective depressive symptoms can be quantified based on the Beck Depression Scale and the Hamilton Depression Scale, which are standardized depression assessment scales, and the decrease in activity associated with depression can be objectively evaluated by analyzing daily activity data collected through a wearable device (not shown).

[0100] Additionally, the response evaluation unit (130) can detect sleep disorders, which are major symptoms of depression, by analyzing the subject's sleep patterns using a sleep tracking app or a sensing module installed on a wearable device (not shown) and / or a user terminal (300). As another example, the response evaluation unit (130) can track changes in the emotional state by analyzing the subject's facial expressions based on artificial intelligence-based video analysis technology, and can also evaluate depressive symptoms appearing in verbal expressions by detecting changes in voice characteristics related to depression using voice analysis technology. Thus, the activity providing device (100) disclosed herein can more accurately and objectively identify the overall behavioral patterns related to depression-like behaviors of the subject before and after participation in the target activity by comprehensively analyzing various data.

[0101] In addition, the reaction evaluation unit (130) can evaluate the microglia activation status of the subject using collected biological data.

[0102] Specifically, the response evaluation unit (130) can evaluate the state of neuroinflammation by measuring and analyzing the degree of activation of microglia in brain regions in response to the subject's participation in target activities using various methods. According to one embodiment of the present invention, the response evaluation unit (130) can directly track inflammatory markers in the brain by using TSPO ligands based on PET scan technology, and can evaluate the state of systemic inflammation by measuring the concentration of biomarkers related to microglia activation, such as GFAP and S100B, using blood analysis technology. In addition, the state of inflammation in the central nervous system can be determined more accurately by measuring the concentration of specific proteins related to microglia activation based on cerebrospinal fluid analysis technology.

[0103] In addition, the reaction evaluation unit (130) can evaluate the subject's astrocyte activation status using collected biological data.

[0104] Specifically, the response evaluation unit (130) can evaluate the state of neuroinflammation and neurodamage by measuring and analyzing the degree of activation of astrocytes from various angles. According to one embodiment of the present invention, the response evaluation unit (130) can non-invasively evaluate the degree of activation of astrocytes by measuring the concentration of myo-inositol in the brain based on MRI spectroscopy technology, and can quantitatively determine the state of inflammation of the central nervous system by measuring the concentration of GFAP using blood or cerebrospinal fluid analysis technology. In addition, it can operate to indirectly evaluate the overall state of astrocyte activation of the central nervous system by observing the degree of activation of astrocytes in the retina based on retinal examination technology.

[0105] In addition, according to one embodiment of the present invention, the response evaluation unit (130) can evaluate the systemic inflammatory state by measuring and analyzing the expression level of inflammatory cytokines in various ways. According to one embodiment of the present invention, the response evaluation unit (130) can quantitatively evaluate the systemic inflammatory state by directly measuring the levels of inflammatory cytokines such as IL-6, IFN-γ, and IL-17A of a subject through a blood test, and routine monitoring is possible by non-invasively measuring cytokine levels through a saliva test. In addition, it can operate to indirectly estimate the systemic inflammatory state by evaluating a local inflammatory response based on skin patch test technology.

[0106] In addition, the response evaluation unit (130) can evaluate the subject's synaptic plasticity using collected biological data.

[0107] Specifically, the response evaluation unit (130) can evaluate the functional state of the neural network by measuring and analyzing changes in synaptic plasticity from various angles. According to one embodiment of the present invention, the response evaluation unit (130) can monitor changes in synaptic plasticity in real time by analyzing brainwaves, particularly alpha wave activity, based on EEG technology, and can evaluate changes in synaptic plasticity at a large network level by analyzing brain functional connectivity using fMRI technology. In addition, changes in synaptic plasticity can be directly measured by evaluating cortical excitability based on transcranial magnetic stimulation (TMS) technology. Furthermore, the actual effect of improving synaptic plasticity can be confirmed by evaluating working memory, attention, learning ability, etc., using cognitive function test technology, and molecular indicators of neural plasticity can be evaluated by measuring BDNF levels based on blood analysis technology.

[0108] Below, based on the details described above, we will briefly examine the operation flow of the present invention.

[0109] FIG. 8 is a flowchart of an operation for a method of providing an activity to improve psychophysiological responses using soil microorganisms according to one embodiment of the present invention.

[0110] The method for providing activities to improve psychophysiological responses using soil microorganisms illustrated in FIG. 8 can be performed by the activity providing device (100) described above. Therefore, even if the content is omitted below, the description of the activity providing device (100) can be equally applied to the description of the method for providing activities to improve psychophysiological responses using soil microorganisms.

[0111] Referring to FIG. 8, in step S11, the activity design unit (110) can obtain design information regarding the soil environment in relation to (a) a target activity performed by a subject using a soil environment inoculated with a target microorganism.

[0112] Next, in step S12, the data collection unit (120) can collect (b) biometric data of the subject who participated in the target activity.

[0113] Next, in step S13, the response evaluation unit (130) can (c) generate evaluation information on the subject's psychophysiological response corresponding to the design information through analysis of the acquired biological data.

[0114] In the description above, steps S11 through S13 may be further divided into additional steps or combined into fewer steps according to an embodiment of the present invention. Additionally, some steps may be omitted as necessary, and the order between steps may be changed.

[0115] Figure 9 is a detailed flowchart of the process for generating evaluation information on the subject's psychophysiological response.

[0116] The process of generating evaluation information regarding the psychophysiological response of the subject illustrated in FIG. 9 can be performed by the activity providing device (100) described above. Therefore, even if the content described below is omitted, the description of the activity providing device (100) can be applied equally to the description of FIG. 9.

[0117] Referring to FIG. 9, in step S131, the reaction evaluation unit (130) can analyze the behavioral pattern of the subject after participation in the target activity using biometric data.

[0118] Next, in step S132, the reaction evaluation unit (130) can evaluate the microglia activation status of the subject using the collected biological data.

[0119] Next, in step S133, the reaction evaluation unit (130) can evaluate the subject's astrocyte activation status using collected biological data.

[0120] Next, in step S134, the response evaluation unit (130) can evaluate the subject's synaptic plasticity using the collected biological data.

[0121] In the description above, steps S131 through S134 may be further divided into additional steps or combined into fewer steps according to an embodiment of the present invention. Additionally, some steps may be omitted as necessary, and the order of the steps may be changed.

[0122] A method for providing an activity for improving psychophysiological responses using soil microorganisms according to one embodiment of the present invention may be implemented in the form of program instructions that can be executed through various computer means and recorded on a computer-readable medium. The computer-readable medium may include program instructions, data files, data structures, etc., either individually or in combination. The program instructions recorded on the medium may be those specifically designed and configured for the present invention, or they may be those known and available to those skilled in the art of computer software. Examples of computer-readable recording media include magnetic media such as hard disks, floppy disks, and magnetic tapes; optical recording media such as CD-ROMs and DVDs; magneto-optical media such as floptical disks; and hardware devices specifically configured to store and execute program instructions, such as ROM, RAM, and flash memory. Examples of program instructions include machine code, such as that generated by a compiler, as well as high-level language code that can be executed by a computer using an interpreter, etc. The above-described hardware device may be configured to operate as one or more software modules to perform the operation of the present invention, and vice versa.

[0123] In addition, the method for providing activities to improve psychophysiological responses using the aforementioned soil microorganisms can also be implemented in the form of a computer program or application executed by a computer stored on a recording medium.

[0124] The foregoing description of the present invention is for illustrative purposes only, and those skilled in the art will understand that other specific forms can be easily modified without altering the technical concept or essential features of the present invention. Therefore, the embodiments described above should be understood as illustrative in all respects and not restrictive. For example, each component described as a single unit may be implemented in a distributed manner, and components described as distributed may likewise be implemented in a combined form.

[0125] The scope of the present invention is defined by the claims set forth below rather than by the detailed description above, and all modifications or variations derived from the meaning and scope of the claims and the concept of equivalents thereof should be interpreted as being included within the scope of the present invention.

[0126] [Explanation of the symbol]

[0127] 10: Psychophysiological Response Analysis System

[0128] 100: Activity providing device for improving psychophysiological responses using soil microorganisms

[0129] 110: Activity Design Department

[0130] 120: Data Collection Unit

[0131] 130: Reaction Evaluation Section

[0132] 200: Database

[0133] 300: User terminal

[0134] 20: Network

Claims

1. Regarding the method of providing activities for improving psychophysiological responses using soil microorganisms, (a) A step of obtaining design information regarding the soil environment in relation to a target activity performed by a subject using a soil environment inoculated with a target microorganism; (b) a step of collecting biometric data of the subject who participated in the above target activity; and (c) a step of generating evaluation information on the psychophysiological response of the subject corresponding to the design information through analysis of the above biological data, A method of providing activities including 2. In Paragraph 1, (d) A step of updating the design information to adjust the soil environment according to the evaluation information, A method of providing activities that further includes 3. In Paragraph 1, The above step (c) is, A step of analyzing the behavioral pattern of the subject after participation in the target activity using the above biometric data, A method of providing an activity that includes 4. In Paragraph 1, The above step (c) is, A step of evaluating the microglia activation status of the subject using the above biological data, A method of providing an activity that includes 5. In Paragraph 1 The above step (c) is, A step of evaluating the astrocyte activation status of the subject using the above biological data, A method of providing an activity that includes 6. In Paragraph 1, The above step (c) is, A step of evaluating the synaptic plasticity of the subject using the above biological data, A method of providing an activity that includes 7. In Paragraph 1, A method for providing activity in which the target microorganism includes Streptomyces rimosus.

8. In Paragraph 2, The above target activity includes horticultural activities performed in the soil environment, and The above step (d) is, A step of determining additional activities other than the gardening activities recommended for the subject to participate in, taking into consideration the above evaluation information, A method of providing an activity that includes 9. In a device for providing activities to improve psychophysiological responses using soil microorganisms, An activity design unit that acquires design information regarding a soil environment in which a subject performs a target activity using a soil environment inoculated with a target microorganism; A data collection unit for collecting biometric data of the subject who participated in the above target activity; and A response evaluation unit that generates evaluation information regarding the psychophysiological response of the subject corresponding to the design information through analysis of the above biological data, An activity providing device including 10. In Paragraph 9, The above activity design department, An activity providing device that updates the design information to adjust the soil environment according to the above evaluation information.

11. In Paragraph 9, The above reaction evaluation unit is, An activity providing device that analyzes the behavioral pattern of the subject after participation in the target activity using the above biometric data.

12. In Paragraph 9, The above reaction evaluation unit is, An activity providing device that evaluates the microglia activation state of the subject using the above biological data.

13. In Paragraph 9, The above reaction evaluation unit is, An activity providing device that evaluates the astrocyte activation state of the subject using the above biological data.

14. In Paragraph 9, The above reaction evaluation unit is, An activity providing device that evaluates the synaptic plasticity of the subject using the above biological data.

15. In Paragraph 10, The above target activity includes horticultural activities performed in the soil environment, and The above activity design department, An activity providing device that determines additional activities other than the gardening activities recommended for the subject to participate in, taking into consideration the above evaluation information.

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