Method and system for separating yttrium [ 90y] from mother liquor containing strontium [ 90sr]

Abstract

A method and a system for separating yttrium [90Y] from a mother liquor containing strontium [90Sr]. The method comprises the following steps: S1: adding a mother liquor containing strontium [90Sr] to a resin separation column, performing rinsing using a rinsing solution, collecting a rinsing solution containing strontium [90Sr], then emptying liquid from the resin separation column using air; S2: using an eluent solution to perform elution, and collecting an eluent solution containing yttrium [90Y], a total volume of the eluent solution used being at least 11 times the volume of the resin separation column. By means of said separation method, it is possible to perform separation and recovery of yttrium [90Y] from a mother liquor containing strontium [90Sr]. In addition, it is possible to increase a strontium [90Sr] recovery rate, bringing the strontium [90Sr] recovery rate to 98% or higher, as well as decreasing the content of other metal contaminants after recovery.

Description

A method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 Y] methods and systems

[0001] Related applications

[0002] This application claims priority to Chinese Patent Application No. 2024115122965, filed on October 28, 2024, entitled “A method and system for separating yttrium [90Y] from strontium [90Sr] mother liquor”. Technical Field

[0003] This invention relates to the field of isotope technology, specifically to a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The methods and systems of Y]. Background Technology

[0004] Yttrium-90 90 Yttrium-90 is a pure beta radioactive nuclide with a half-life of 64 hours. The beta rays produced during its decay can reach a maximum energy of 2.28 MeV. 90 The decay product 90Zr of Y is stable and non-toxic, and will not affect the human body. Furthermore, yttrium-90[ 90 Yttrium-90 (Y-90) possesses excellent chelating chemical properties and is easily labeled into monoclonal antibodies, microspheres, peptides, etc., for in vivo radiotherapy of cancer. Related radiopharmaceuticals and products prepared using Y-90 as a raw material include yttrium-90[…]. 90 Y]-labeled monoclonal antibody, yttrium-90[ 90 Y] microspheres and yttrium-90[ 90 [Y]-labeled peptides, etc., have broad market application prospects. Through strontium [ 90 Sr]-Yttrium-90[ 90 Y]Nucleotide generator to obtain yttrium-90[ 90 Y] has the advantages of simple and quick operation and no regional restrictions, and the raw material used is strontium [ 90 Sr]- is uranium [ 235 The fission products of U] can be obtained from spent fuel that has been cooled for a long time, which is currently the best way to obtain yttrium-90. 90 The main method of Y].

[0005] Yttrium-90 90 Y] and Strontium-90[ 90Separation of yttrium and strontium (Sr) is a challenging task due to their similar chemical properties. Three common methods are employed: 1. Precipitation: This method utilizes the differences in precipitation characteristics of different compounds under specific conditions. A suitable precipitant can be added to cause one element to precipitate while the other remains in solution. For example, for certain anions, yttrium can form a sparingly soluble salt precipitate, while strontium remains dissolved under the same conditions. The precipitate is then separated from the solution through filtration or other operations, achieving preliminary separation. However, this method usually requires precise control of reaction conditions, and the separation effect may not be ideal, often necessitating further purification using other methods. 2. Ion exchange: A solution containing yttrium and strontium is passed through an ion exchange column, where yttrium and strontium ions are adsorbed by the resin. Then, by using different eluents, yttrium and strontium can be selectively eluted from the resin. 3. Solvent extraction method: An aqueous solution containing yttrium and strontium is mixed with an extractant. Under certain conditions (such as specific pH value, temperature, etc.), yttrium and strontium will partition between the organic phase and the aqueous phase according to their affinity with the extractant. However, ion exchange is used to separate strontium-90[…]. 90 Yttrium-90 in the mother liquor [Sr] 90 Y] will contain Strontium-90[ 90 The recovery rate of Sr was low and the impurity content was high. Furthermore, given the hazards of radionuclides to humans and the environment, yttrium-90 […]. 90 Y] and Strontium-90[ 90 Safety during the separation process of Sr is also an issue that urgently needs to be addressed. Summary of the Invention

[0006] To solve the above-mentioned technical problems, the present invention provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method and system of Y] can improve the strontium [ 90 The recovery rate of Sr] makes the recovery rate of Sr[ 90 The recovery rate of Sr is over 98%, and it can also reduce the content of other metal impurities after recovery.

[0007] Therefore, the present invention provides the following technical solution:

[0008] In a first aspect, the present invention provides, in optional embodiments, a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method of Y] includes the following steps:

[0009] S1: Strontium-containing [ 90 The mother liquor containing strontium (Sr) was added to a resin separation column, eluted with eluent, and the strontium-containing [Sr] content was collected. 90The eluent of Sr] is then purged from the resin separation column with air;

[0010] S2: Elute with eluent and collect the yttrium-containing [ 90 The elution buffer of Y];

[0011] The total volume of the eluent used is at least 11 times the volume of the resin separation column.

[0012] Preferably, the flow rate of the eluent is 0.25-0.5 mL / min before the total volume of the eluent used reaches 9 times the volume of the resin separation column, and the flow rate of the eluent is 0.5-0.75 mL / min after the total volume of the eluent used reaches 9 times the volume of the resin separation column.

[0013] Preferably, the total volume of the eluent used is at least 5 times the volume of the resin separation column, and the flow rate of the eluent is 0.5-0.75 mL / min.

[0014] Preferably, the strontium-containing [ 90 The mother liquor containing strontium (Sr) was added in 5 portions; and / or, each portion contained strontium (Sr). 90 The volume of the mother liquor [Sr] is 1 times the volume of the resin separation column.

[0015] Preferably, in the presence of yttrium [ 90 Strontium of Y] 90 In the mother liquor of Sr], the strontium[ 90 Sr] and yttrium 90 The radioactivity ratio of Y] is less than 10. -5 .

[0016] Preferably, before step S1, the process further includes an acid equilibration step of eluing the resin separation column with an eluent; and / or, the eluent is an 8 mol / L hydrochloric acid solution; and / or, the eluent is a 1 mol / L hydrochloric acid solution.

[0017] Furthermore, the first six-way valve is used to [dispose of the yttrium-containing...] 90 Strontium of Y] 90 The mother liquor, eluent, elution solution, and resin separation column are connected, and the separated liquid is collected using a second six-way valve, including the following steps:

[0018] S1: Retain 0.5 mL of air at the common port C near the first six-way valve;

[0019] S2: The eluent is transported to the resin separation column through the first six-way valve for acid equilibration, and then the acid-equilibrated liquid is collected through the second six-way valve;

[0020] S3: The yttrium-containing [[] is supplied through the first six-way valve. 90 Strontium of Y] 90 The mother liquor is transported to a resin separation column for separation, and then the separated liquid is collected through the second six-way valve;

[0021] S4: The rinsing liquid is transported to the resin separation column for rinsing through the first six-way valve, and the rinsed liquid is collected through the second six-way valve. Then, air is transported to the resin separation column through the first six-way valve to drain the liquid in the resin separation column.

[0022] S5: The eluent is conveyed to the resin separation column for elution through the first six-way valve, and then the eluted liquid is collected through the second six-way valve, completing the elution of the yttrium-containing liquid. 90 Strontium of Y] 90 Yttrium in mother liquor [Sr] 90 Separation of Y].

[0023] Secondly, in an optional embodiment, the present invention provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The system of Y] includes a mother liquor tank, a first rinsing tank, a second rinsing tank, a first waste liquid tank, a second waste liquid tank, a first elution tank, a second elution tank, a cleaning tank, a first six-way valve, a second six-way valve, a power unit, a separation device, and a software control device;

[0024] One end of the power unit is connected to the cleaning tank, and the other end is connected to the common port C of the first six-way valve, for transporting the liquid in the mother liquor tank, the first rinsing tank, the first waste liquid tank, the first elution tank, and the cleaning tank to the separation device;

[0025] The first six-way valve has port 1 connected to the first rinsing tank, port 2 connected to the mother liquor tank, port 3 connected to the first elution tank, port 4 connected to the first waste liquid tank, port 5 connected to air, and port 6 connected to the liquid inlet of the separation device.

[0026] The common port C of the second six-way valve is connected to the liquid outlet of the separation device, port 1 is connected to the second waste liquid tank, port 2 is connected to the second rinsing tank, and port 3 is connected to the second elution tank.

[0027] The software control device is connected to the power device, the first six-way valve, and the second six-way valve via signal connections.

[0028] Preferably, the liquid-contact material of the first and second six-way valves is selected from polychlorotrifluoroethylene or sapphire. The power unit is an injection pump; the liquid volume accuracy error of the injection pump is less than 1%. The separation device is a resin separation column; and / or, the liquid in the washing tank is deionized water; and / or, the liquid in the first rinsing tank is a 1 mol / L hydrochloric acid solution; and / or, the liquid in the first elution tank is an 8 mol / L hydrochloric acid solution.

[0029] In this invention, the central holes of the first and second six-way valves serve as a common channel, allowing for multi-channel switching via a rotor to enable alternating passage of different solutions for material separation. The flow channel diameter is 1.2 mm, the port-to-port volume is 27.5 μL, the rotor groove volume is 5.41 μL, the liquid contact material is PCTEF or sapphire, the tubing interface is a 1 / 4-28 UNF threaded connector, the switching time is less than 4 seconds per revolution, and the maximum driving force is 4 N / m. The syringe pump is designed with a volume accuracy error of less than 1% and a volume repeatability error of 0.3%-0.5%. Depending on the actual application, different sizes of syringes from 50 μL to 10 mL can be selected, with a 1 / 4-28 UNF threaded connector and a rated stroke running time of 2 seconds to 12000 seconds (pure water medium). The software control device requires control of the power unit, the first and second six-way valves, and includes a 485 hub and a miniature touchscreen. The power unit, the first six-way valve, and the second six-way valve communicate via a 485 hub and a miniature touchscreen. The host computer software sends control commands to the 485 hub using the computer's serial port, and the hub then distributes the commands to each device, thereby controlling the hardware. The sealing material for the separator column cover is thermoplastic polyurethane elastomer rubber, and the intermediate threads are made of polyetheretherketone (PEEK).

[0030] Compared with the prior art, the present invention has one of the following beneficial effects:

[0031] 1. The separation method of the present invention can achieve the separation of strontium [ 90 Yttrium in mother liquor [Sr] 90 The separation and recovery of Y] can improve the efficiency of strontium [ 90 The recovery rate of Sr can reach over 98%, and it can also reduce the content of other metal impurities after recovery.

[0032] 2. This invention can achieve the production of yttrium-containing [ 90 Strontium of Y] 90 In the mother liquor of Sr, strontium [ 90 Sr] and yttrium 90 Y] Radioactivity ratio less than 10 -5 The separation.

[0033] 3. This invention greatly improves the performance of yttrium-90.90 Y] and Strontium-90[ 90 The safety of the separation process of Sr was ensured, avoiding the huge harm caused by reflective leakage. Attached Figure Description

[0034] To more clearly illustrate the technical solutions in the embodiments of the present invention, the accompanying drawings used in the embodiments will be briefly introduced below. Obviously, the drawings described below are only some embodiments of the present invention. For those skilled in the art, other drawings can be obtained based on these drawings without creative effort.

[0035] Figure 1 is a system flowchart of Embodiment 1 of the present invention. Detailed Implementation

[0036] To make the objectives, technical solutions, and advantages of this invention clearer, the invention will be further described in detail below with reference to specific embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and are not intended to limit the invention.

[0037] Example 1

[0038] This embodiment provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The system of Y] includes a mother liquor tank, a first rinsing tank, a second rinsing tank, a first waste liquid tank, a second waste liquid tank, a first elution tank, a second elution tank, a cleaning tank, a first six-way valve, a second six-way valve, a power unit, a separation unit, and a software control unit;

[0039] One end of the power unit is connected to the cleaning tank, and the other end is connected to the common port C of the first six-way valve. This power unit is used to transport liquids from the mother liquor tank, the first rinsing tank, the first waste liquid tank, the first elution tank, and the cleaning tank to the separation device. The power unit is a syringe pump, which provides power to drive the liquid in the automatic separation device. In the syringe pump, the motor drives the conveyor belt, which in turn rotates synchronously with the lead screw, which in turn moves the piston up and down. The syringe pump is designed with a liquid volume accuracy error of less than 1% and a liquid volume repeatability error of 0.3%-0.5%. Different sizes of syringes, from 50μL to 10mL, can be selected depending on the actual application. The tubing interface is a 1 / 4-28UNF threaded interface, and the rated stroke running time is 2s-12000s (pure water medium).

[0040] The first six-way valve has port 1 connected to the first rinsing tank, port 2 connected to the mother liquor tank, port 3 connected to the first elution tank, port 4 connected to the first waste liquid tank, port 5 connected to air, and port 6 connected to the liquid inlet of the separation device.

[0041] The common port C of the second six-way valve is connected to the liquid outlet of the separation device, port 1 is connected to the second waste liquid tank, port 2 is connected to the second rinsing tank, and port 3 is connected to the second elution tank.

[0042] The central holes of the first and second six-way valves share a common channel, allowing for multi-channel switching via the rotor to enable alternating passage of different solutions through the separation material. The flow channel diameter is 1.2 mm, the port-to-port volume is 27.5 μL, the rotor groove volume is 5.41 μL, the liquid contact material is PCTEF or sapphire, the piping interface is a 1 / 4-28 UNF threaded interface, the switching time is less than 4 seconds per revolution, and the maximum driving force is 4 N / m. The sealing material for the separation column cap is thermoplastic polyurethane elastomer rubber, and the intermediate threads are made of polyetheretherketone (PEEK).

[0043] The software control device is connected to the power unit, the first six-way valve, and the second six-way valve via signal connections. The hardware controlled by the software control device includes the power unit, the first six-way valve, and the second six-way valve. The hardware used includes a 485 hub and a miniature touchscreen. The power unit, the first six-way valve, and the second six-way valve communicate via the 485 hub and the miniature touchscreen. The host computer software sends control commands to the 485 hub using the computer's serial port, and the hub then distributes the commands to the respective devices, thereby achieving control of the hardware.

[0044] The separation device is a resin separation column, the liquid in the washing tank is deionized water; the liquid in the first rinsing tank is a 1 mol / L hydrochloric acid solution; and the liquid in the first elution tank is an 8 mol / L hydrochloric acid solution.

[0045] Example 2

[0046] This embodiment provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0047] Specifically, the following steps are included:

[0048] S1: Retain 0.5 mL of air at the common port C near the first six-way valve;

[0049] S2: Draw eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 1 and discharge the eluent into the second waste tank at a rate of 1 mL / min. Empty the air in the resin separation column and perform acid equilibration on the resin.

[0050] S3: Draw 2 mL of yttrium-containing solution from port 2 of the first six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] Mother liquor (Sr in mother liquor) 90 The content of Sr was 0.7 g / ml, and the content of yttrium was […]. 90 The content of Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the strontium [ 90 Sr] and yttrium 90 The radioactivity ratio of Y] is 2.76 × 10⁻⁶. -6 Switch the first six-way valve to port 6 and pass the mother liquor through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 2 and discharge the solution at a rate of 1 mL / min. Collect the effluent. Follow step S3 to aspirate a total of […]. 90 Strontium of Y] 90 10 mL of Sr] stock solution;

[0051] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve. Switch the first six-way valve to port 6 and the second six-way valve to port 1. Before the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.43 mL / min. After the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.75 mL / min and discharge the eluent into the second eluent tank at a rate of 1 mL / min. Switch the first six-way valve to port 5 and use air to purge the liquid in the resin separation column.

[0052] S5: Draw 3 mL of eluent (8 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from port 3 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 3 and discharge the eluent into the second elution tank at a rate of 1 mL / min.

[0053] S6: Draw deionized water from the cleaning tank at a rate of 5 ml / min from the common port C of the first six-way valve, switch the first six-way valve to port 6#, and let the eluent pass through the resin separation column at a rate of 0.25 ml / min. Switch the second six-way valve to port 1# and discharge the deionized water into the second waste tank at a rate of 1 ml / min.

[0054] Example 3

[0055] This embodiment provides a method for separating strontium-containing [90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0056] Specifically, the following steps are included:

[0057] S1: Retain 0.5 mL of air at the common port C near the first six-way valve;

[0058] S2: Draw eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 1 and discharge the eluent into the second waste tank at a rate of 1 mL / min. Empty the air in the resin separation column and perform acid equilibration on the resin.

[0059] S3: Draw 2 mL of yttrium-containing solution from port 2 of the first six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] Mother liquor (Sr in mother liquor) 90 The content of Sr was 0.7 g / ml, and the content of yttrium was […]. 90 The content of Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the strontium [ 90 Sr] and yttrium 90 The radioactivity ratio of Y] is 2.44 × 10⁻⁶. -6 Switch the first six-way valve to port 6 and pass the mother liquor through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 2 and discharge the solution at a rate of 1 mL / min. Collect the effluent. Follow step S3 to aspirate a total of […]. 90 Strontium of Y] 90 10 mL of Sr] stock solution;

[0060] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve. Switch the first six-way valve to port 6 and the second six-way valve to port 1. Before the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.43 mL / min. After the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.75 mL / min and discharge the eluent into the second eluent tank at a rate of 1 mL / min. Switch the first six-way valve to port 5 and use air to purge the liquid in the resin separation column.

[0061] S5: Draw 3 mL of eluent (8 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from port 3 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 3 and discharge the eluent into the second elution tank at a rate of 1 mL / min.

[0062] S6: Draw deionized water from the cleaning tank at a rate of 5 ml / min from the common port C of the first six-way valve, switch the first six-way valve to port 6#, and let the eluent pass through the resin separation column at a rate of 0.25 ml / min. Switch the second six-way valve to port 1# and discharge the deionized water into the second waste tank at a rate of 1 ml / min.

[0063] Example 4

[0064] This embodiment provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0065] Specifically, the following steps are included:

[0066] S1: Retain 0.5 mL of air at the common port C near the first six-way valve;

[0067] S2: Draw eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 1 and discharge the eluent into the second waste tank at a rate of 1 mL / min. Empty the air in the resin separation column and perform acid equilibration on the resin.

[0068] S3: Draw 2 mL of yttrium-containing solution from port 2 of the first six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] Mother liquor (Sr in mother liquor) 90 The content of Sr was 0.7 g / ml, and the content of yttrium was […]. 90 The content of Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the strontium [ 90 Sr] and yttrium 90 The radioactivity ratio of Y] is 2.91 × 10⁻⁶. -6Switch the first six-way valve to port 6 and pass the mother liquor through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 2 and discharge the solution at a rate of 1 mL / min. Collect the effluent. Follow step S3 to aspirate a total of […]. 90 Strontium of Y] 90 10 mL of Sr] stock solution;

[0069] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve. Switch the first six-way valve to port 6 and the second six-way valve to port 1. Before the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.43 mL / min. After the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.75 mL / min and discharge the eluent into the second eluent tank at a rate of 1 mL / min. Switch the first six-way valve to port 5 and use air to purge the liquid in the resin separation column.

[0070] S5: Draw 3 mL of eluent (8 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from port 3 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 3 and discharge the eluent into the second elution tank at a rate of 1 mL / min.

[0071] S6: Draw deionized water from the cleaning tank at a rate of 5 ml / min from the common port C of the first six-way valve, switch the first six-way valve to port 6#, and let the eluent pass through the resin separation column at a rate of 0.25 ml / min. Switch the second six-way valve to port 1# and discharge the deionized water into the second waste tank at a rate of 1 ml / min.

[0072] Example 5

[0073] This embodiment provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0074] Specifically, the following steps are included:

[0075] S1: Retain 0.5 mL of air at the common port C near the first six-way valve;

[0076] S2: Draw eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.1 mL / min. Switch the second six-way valve to port 1, and discharge the eluent into the second waste tank at a rate of 1 mL / min. Empty the air in the resin separation column and perform acid equilibration on the resin.

[0077] S3: Draw 2 mL of yttrium-containing solution from port 2 of the first six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] Mother liquor (Sr in mother liquor) 90 The content of Sr was 0.7 g / ml, and the content of yttrium was […]. 90 The content of Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the strontium [ 90 Sr] and yttrium 90 The radioactivity ratio of Y] is 7.59 × 10⁻⁶. -7 Switch the first six-way valve to port 6 and pass the mother liquor through the resin separation column at a rate of 0.1 mL / min. Switch the second six-way valve to port 2 and discharge the solution at a rate of 1 mL / min. Collect the effluent. Follow step S3 to collect a total of […]. 90 Strontium of Y] 90 10 mL of Sr] stock solution;

[0078] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve. Switch the first six-way valve to port 6 and the second six-way valve to port 1. Before the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.43 mL / min. After the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.75 mL / min and discharge the eluent into the second eluent tank at a rate of 1 mL / min. Switch the first six-way valve to port 5 and use air to purge the liquid in the resin separation column.

[0079] S5: Draw 3 mL of eluent (8 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from port 3 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.1 mL / min. Switch the second six-way valve to port 3 and discharge the eluent into the second elution tank at a rate of 1 mL / min.

[0080] S6: Draw deionized water from the cleaning tank at a rate of 5 ml / min from the common port C of the first six-way valve, switch the first six-way valve to port 6#, and let the eluent pass through the resin separation column at a rate of 0.1 ml / min. Switch the second six-way valve to port 1# and discharge the deionized water into the second waste tank at a rate of 1 ml / min.

[0081] Example 6

[0082] This embodiment provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0083] Specifically, the following steps are included:

[0084] S1: Retain 0.5 mL of air at the common port C near the first six-way valve;

[0085] S2: Draw eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 1 and discharge the eluent into the second waste tank at a rate of 1 mL / min. Empty the air in the resin separation column and perform acid equilibration on the resin.

[0086] S3: Draw 2 mL of yttrium-containing solution from port 2 of the first six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] Mother liquor (Sr in mother liquor) 90 The content of Sr was 0.7 g / ml, and the content of yttrium was […]. 90 The content of Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the strontium [ 90 Sr] and yttrium 90 The radioactivity ratio of Y] is 8.78 × 10⁻⁶. -7 Switch the first six-way valve to port 6 and pass the mother liquor through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 2 and discharge the solution at a rate of 1 mL / min. Collect the effluent. Follow step S3 to aspirate a total of […]. 90 Strontium of Y] 90 10 mL of Sr] stock solution;

[0087] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve. Switch the first six-way valve to port 6 and the second six-way valve to port 1. Before the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.43 mL / min. After the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.75 mL / min and discharge the eluent into the second eluent tank at a rate of 1 mL / min. Switch the first six-way valve to port 5 and use air to purge the liquid in the resin separation column.

[0088] S5: Draw 3 mL of eluent (8 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from port 3 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 3 and discharge the eluent into the second elution tank at a rate of 1 mL / min.

[0089] S6: Draw deionized water from the cleaning tank at a rate of 5 ml / min from the common port C of the first six-way valve, switch the first six-way valve to port 6#, and let the eluent pass through the resin separation column at a rate of 0.25 ml / min. Switch the second six-way valve to port 1# and discharge the deionized water into the second waste tank at a rate of 1 ml / min.

[0090] Example 7

[0091] This embodiment provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0092] Specifically, the following steps are included:

[0093] S1: Retain 0.5 mL of air at the common port C near the first six-way valve;

[0094] S2: Draw eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.5 mL / min. Switch the second six-way valve to port 1, and discharge the eluent into the second waste tank at a rate of 1 mL / min. Empty the air in the resin separation column and perform acid equilibration on the resin.

[0095] S3: Draw 2 mL of yttrium-containing solution from port 2 of the first six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] Mother liquor (Sr in mother liquor) 90 The content of Sr was 0.7 g / ml, and the content of yttrium was […]. 90 The content of Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the strontium [ 90 Sr] and yttrium 90 The radioactivity ratio of Y] is 9.48 × 10⁻⁶. -7 Switch the first six-way valve to port 6 and pass the mother liquor through the resin separation column at a rate of 0.5 mL / min. Switch the second six-way valve to port 2 and discharge the solution at a rate of 1 mL / min. Collect the effluent. Follow step S3 to collect a total of […]. 90 Strontium of Y] 90 10 mL of Sr] stock solution;

[0096] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve. Switch the first six-way valve to port 6 and the second six-way valve to port 1. Before the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.5 mL / min. After the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.5 mL / min and discharge the eluent into the second eluent tank at a rate of 1 mL / min. Switch the first six-way valve to port 5 and use air to purge the liquid in the resin separation column.

[0097] S5: Draw 3 mL of eluent (8 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from port 3 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.5 mL / min. Switch the second six-way valve to port 3 and discharge the eluent into the second elution tank at a rate of 1 mL / min.

[0098] S6: Draw deionized water from the cleaning tank at a rate of 5 ml / min from the common port C of the first six-way valve, switch the first six-way valve to port 6#, and let the eluent pass through the resin separation column at a rate of 0.5 ml / min. Switch the second six-way valve to port 1# and discharge the deionized water into the second waste tank at a rate of 1 ml / min.

[0099] Example 8

[0100] This embodiment provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr)90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0101] Specifically, the following steps are included:

[0102] S1: Retain 0.5 mL of air at the common port C near the first six-way valve;

[0103] S2: Draw eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 1 and discharge the eluent into the second waste tank at a rate of 1 mL / min. Empty the air in the resin separation column and perform acid equilibration on the resin.

[0104] S3: Draw 2 mL of yttrium-containing solution from port 2 of the first six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] Mother liquor (Sr in mother liquor) 90 The content of Sr was 0.7 g / ml, and the content of yttrium was […]. 90 The content of Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the strontium [ 90 Sr] and yttrium 90 The radioactivity ratio of Y] is 2.76 × 10⁻⁶. -6 Switch the first six-way valve to port 6 and pass the mother liquor through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 2 and discharge the solution at a rate of 1 mL / min. Collect the effluent. Follow step S3 to aspirate a total of […]. 90 Strontium of Y] 90 10 mL of Sr] stock solution;

[0105] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve. Switch the first six-way valve to port 6 and the second six-way valve to port 1. Before the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.25 mL / min. After the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.75 mL / min and discharge the eluent into the second eluent tank at a rate of 1 mL / min. Switch the first six-way valve to port 5 and use air to purge the liquid in the resin separation column.

[0106] S5: Draw 3 mL of eluent (8 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from port 3 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 3 and discharge the eluent into the second elution tank at a rate of 1 mL / min.

[0107] S6: Draw deionized water from the cleaning tank at a rate of 5 ml / min from the common port C of the first six-way valve, switch the first six-way valve to port 6#, and let the eluent pass through the resin separation column at a rate of 0.25 ml / min. Switch the second six-way valve to port 1# and discharge the deionized water into the second waste tank at a rate of 1 ml / min.

[0108] Example 9

[0109] This embodiment provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0110] The difference between the steps in this embodiment and those in Embodiment 2 lies in step S4. Step S4 in this comparative example is as follows: 9 mL of eluent (1 mol / L hydrochloric acid solution) is drawn from the first eluent tank at a rate of 5 mL / min from port 1# of the first six-way valve. The first six-way valve is switched to port 6#, and the second six-way valve is switched to port 1#. The eluent passes through the resin separation column at a rate of 0.75 mL / min and is discharged into the second eluent tank at a rate of 1 mL / min. The first six-way valve is switched to port 5#, and air is used to purge the liquid in the resin separation column.

[0111] The remaining steps are the same as in Example 2.

[0112] Comparative Example 1

[0113] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 2 mL and the product solution is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0114] Specifically, the following steps are included:

[0115] S1: Retain 0.5 mL of air at the common port C near the first six-way valve;

[0116] S2: Draw eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 1 and discharge the eluent into the second waste tank at a rate of 1 mL / min. Empty the air in the resin separation column and perform acid equilibration on the resin.

[0117] S3: Draw 2 mL of yttrium-containing solution from port 2 of the first six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] Mother liquor (Sr in mother liquor) 90 The content of Sr was 0.7 g / ml, and the content of yttrium was […]. 90 The content of Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the strontium [ 90 Sr] and yttrium 90 The radioactivity ratio of Y] is 1.36 × 10⁻⁶. -6 Switch the first six-way valve to port 6 and pass the mother liquor through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 2 and discharge the solution at a rate of 1 mL / min. Collect the effluent. Follow step S3 to aspirate a total of […]. 90 Strontium of Y] 90 10 mL of Sr] stock solution;

[0118] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve. Switch the first six-way valve to port 6 and the second six-way valve to port 1. Before the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.43 mL / min. Before the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.75 mL / min and discharge the eluent into the second eluent tank at a rate of 1 mL / min. Switch the first six-way valve to port 5 and use air to purge the liquid in the resin separation column.

[0119] S5: Draw 3 mL of eluent (8 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from port 3 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 3 and discharge the eluent into the second elution tank at a rate of 1 mL / min.

[0120] S6: Draw deionized water from the cleaning tank at a rate of 5 ml / min from the common port C of the first six-way valve, switch the first six-way valve to port 6#, and let the eluent pass through the resin separation column at a rate of 0.25 ml / min. Switch the second six-way valve to port 1# and discharge the deionized water into the second waste tank at a rate of 1 ml / min.

[0121] Comparative Example 2

[0122] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 2 mL and the product solution is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0123] Specifically, the following steps are included:

[0124] S1: Retain 0.5 mL of air at the common port C near the first six-way valve;

[0125] S2: Draw eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.5 mL / min. Switch the second six-way valve to port 1, and discharge the eluent into the second waste tank at a rate of 1 mL / min. Empty the air in the resin separation column and perform acid equilibration on the resin.

[0126] S3: Draw 2 mL of yttrium-containing solution from port 2 of the first six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] Mother liquor (Sr in mother liquor) 90 The content of Sr was 0.7 g / ml, and the content of yttrium was […]. 90 The content of Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the strontium [ 90 Sr] and yttrium 90 The radioactivity ratio of Y] is 2.91 × 10⁻⁶. -6 Switch the first six-way valve to port 6 and pass the mother liquor through the resin separation column at a rate of 0.5 mL / min. Switch the second six-way valve to port 2 and discharge the solution at a rate of 1 mL / min. Collect the effluent. Follow step S3 to collect a total of […]. 90 Strontium of Y] 90 10 mL of Sr] stock solution;

[0127] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve. Switch the first six-way valve to port 6 and the second six-way valve to port 1. Before the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.5 mL / min. After the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.5 mL / min and discharge the eluent into the second eluent tank at a rate of 1 mL / min. Switch the first six-way valve to port 5 and use air to purge the liquid in the resin separation column.

[0128] S5: Draw 3 mL of eluent (8 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from port 3 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.5 mL / min. Switch the second six-way valve to port 3 and discharge the eluent into the second elution tank at a rate of 1 mL / min.

[0129] S6: Draw deionized water from the cleaning tank at a rate of 5 ml / min from the common port C of the first six-way valve, switch the first six-way valve to port 6#, and let the eluent pass through the resin separation column at a rate of 0.5 ml / min. Switch the second six-way valve to port 1# and discharge the deionized water into the second waste tank at a rate of 1 ml / min.

[0130] Comparative Example 3

[0131] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 2 mL and the product solution is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0132] Specifically, the following steps are included:

[0133] S1: Retain 0.5 mL of air at the common port C near the first six-way valve;

[0134] S2: Draw eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.8 mL / min. Switch the second six-way valve to port 1, and discharge the eluent into the second waste tank at a rate of 1 mL / min. Empty the air in the resin separation column and perform acid equilibration on the resin.

[0135] S3: Draw 2 mL of yttrium-containing solution from port 2 of the first six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] Mother liquor (Sr in mother liquor) 90 The content of Sr was 0.7 g / ml, and the content of yttrium was […]. 90 The content of Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the strontium [ 90 Sr] and yttrium 90 The radioactivity ratio of Y] is 6.21 × 10⁻⁶. -6 Switch the first six-way valve to port 6 and pass the mother liquor through the resin separation column at a rate of 0.8 mL / min. Switch the second six-way valve to port 2 and discharge the solution at a rate of 1 mL / min. Collect the effluent. Follow step S3 to collect a total of […]. 90 Strontium of Y] 90 10 mL of Sr] stock solution;

[0136] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve. Switch the first six-way valve to port 6 and the second six-way valve to port 1. Before the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.8 mL / min. After the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.8 mL / min and discharge the eluent into the second eluent tank at a rate of 1 mL / min. Switch the first six-way valve to port 5 and use air to purge the liquid in the resin separation column.

[0137] S5: Draw 3 mL of eluent (8 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from port 3 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.8 mL / min. Switch the second six-way valve to port 3 and discharge the eluent into the second elution tank at a rate of 1 mL / min.

[0138] S6: Draw deionized water from the cleaning tank at a rate of 5 ml / min from the common port C of the first six-way valve, switch the first six-way valve to port 6#, and let the eluent pass through the resin separation column at a rate of 0.8 ml / min. Switch the second six-way valve to port 1# and discharge the deionized water into the second waste tank at a rate of 1 ml / min.

[0139] Comparative Example 4

[0140] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr)90 The method described in Example 1 uses a resin separation column with a volume of 2 mL and the product solution is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0141] Specifically, the following steps are included:

[0142] S1: Retain 0.5 mL of air at the common port C near the first six-way valve;

[0143] S2: Draw eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 1 and discharge the eluent into the second waste tank at a rate of 1 mL / min. Empty the air in the resin separation column and perform acid equilibration on the resin.

[0144] S3: Draw 2 mL of yttrium-containing solution from port 2 of the first six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] Mother liquor (Sr in mother liquor) 90 The content of Sr was 0.7 g / ml, and the content of yttrium was […]. 90 The content of Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the strontium [ 90 Sr] and yttrium 90 The radioactivity ratio of Y] is 2.76 × 10⁻⁶. -6 Switch the first six-way valve to port 6 and pass the mother liquor through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 2 and discharge the solution at a rate of 1 mL / min. Collect the effluent. Follow step S3 to aspirate a total of […]. 90 Strontium of Y] 90 10 mL of Sr] stock solution;

[0145] S4: Draw 11 mL of eluent (1 mol / L hydrochloric acid solution) from the first eluent tank at a rate of 5 mL / min from port 1 of the first six-way valve. Switch the first six-way valve to port 6 and the second six-way valve to port 1. Before the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.43 mL / min. After the total volume of the eluent used reaches 9 mL, pass the eluent through the resin separation column at a rate of 0.75 mL / min and discharge the eluent into the second eluent tank at a rate of 1 mL / min. Switch the first six-way valve to port 5 and use air to purge the liquid in the resin separation column.

[0146] S5: Draw 3 mL of eluent (8 mol / L hydrochloric acid solution) from the first elution tank at a rate of 5 mL / min from port 3 of the first six-way valve, switch the first six-way valve to port 6, and let the eluent pass through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 3 and discharge the eluent into the second elution tank at a rate of 1 mL / min.

[0147] S6: Draw deionized water from the cleaning tank at a rate of 5 ml / min from the common port C of the first six-way valve, switch the first six-way valve to port 6#, and let the eluent pass through the resin separation column at a rate of 0.25 ml / min. Switch the second six-way valve to port 1# and discharge the deionized water into the second waste tank at a rate of 1 ml / min.

[0148] Comparative Example 5

[0149] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0150] The difference between this comparative example and Example 2 lies in step S3. Step S3 in this comparative example is: 10 mL of yttrium-containing solution is drawn from port #2 of the first six-way valve at a rate of 0.5 mL / min from the mother liquor tank. 90 Strontium of Y] 90 Sr] Mother liquor (Sr in mother liquor) 90 The content of Sr was 0.7 g / ml, and the content of yttrium was […]. 90 The content of Y] is 20 μg / ml, the hydrochloric acid is 1 mol / L, and the strontium [ 90 Sr] and yttrium 90 The radioactivity ratio of Y] is 2.76 × 10⁻⁶. -6 Switch the first six-way valve to port 6# and pass the mother liquor through the resin separation column at a rate of 0.25 mL / min. Switch the second six-way valve to port 2# and discharge the solution at a rate of 1 mL / min. Collect the effluent.

[0151] The remaining steps are the same as in Example 2.

[0152] Comparative Example 6

[0153] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0154] The difference between the steps of this comparative example and Example 2 lies in step S4. Step S4 of this comparative example is as follows: 11 mL of eluent (1 mol / L hydrochloric acid solution) is drawn from the first eluent tank at a rate of 5 mL / min from port 1# of the first six-way valve. The first six-way valve is switched to port 6#, and the second six-way valve is switched to port 1#. Before the total volume of the eluent used reaches 9 mL, the eluent is passed through the resin separation column at a rate of 0.2 mL / min. After the total volume of the eluent used reaches 9 mL, the eluent is passed through the resin separation column at a rate of 0.75 mL / min, and the eluent is discharged into the second eluent tank at a rate of 1 mL / min. The first six-way valve is switched to port 5#, and the liquid in the resin separation column is emptied using air.

[0155] The remaining steps are the same as in Example 2.

[0156] Comparative Example 7

[0157] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0158] The difference between the steps of this comparative example and Example 2 lies in step S4. Step S4 of this comparative example is as follows: 11 mL of eluent (1 mol / L hydrochloric acid solution) is drawn from the first eluent tank at a rate of 5 mL / min from port 1# of the first six-way valve. The first six-way valve is switched to port 6#, and the second six-way valve is switched to port 1#. Before the total volume of the eluent used reaches 9 mL, the eluent is passed through the resin separation column at a rate of 0.55 mL / min. After the total volume of the eluent used reaches 9 mL, the eluent is passed through the resin separation column at a rate of 0.75 mL / min, and the eluent is discharged into the second eluent tank at a rate of 1 mL / min. The first six-way valve is switched to port 5#, and the liquid in the resin separation column is emptied using air.

[0159] The remaining steps are the same as in Example 2.

[0160] Comparative Example 8

[0161] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0162] The difference between the steps of this comparative example and Example 2 lies in step S4. Step S4 of this comparative example is as follows: 11 mL of eluent (1 mol / L hydrochloric acid solution) is drawn from the first eluent tank at a rate of 5 mL / min from port 1# of the first six-way valve. The first six-way valve is switched to port 6#, and the second six-way valve is switched to port 1#. Before the total volume of the eluent used reaches 3 mL, the eluent is passed through the resin separation column at a rate of 0.43 mL / min. After the total volume of the eluent used reaches 3 mL, the eluent is passed through the resin separation column at a rate of 0.75 mL / min, and the eluent is discharged into the second eluent tank at a rate of 1 mL / min. The first six-way valve is switched to port 5#, and the liquid in the resin separation column is emptied using air.

[0163] The remaining steps are the same as in Example 2.

[0164] Comparative Example 9

[0165] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0166] The difference between the steps of this comparative example and Example 2 lies in step S4. Step S4 of this comparative example is as follows: 11 mL of eluent (1 mol / L hydrochloric acid solution) is drawn from the first eluent tank at a rate of 5 mL / min from port 1# of the first six-way valve. The first six-way valve is switched to port 6#, and the second six-way valve is switched to port 1#. Before the total volume of the eluent used reaches 5 mL, the eluent is passed through the resin separation column at a rate of 0.43 mL / min. After the total volume of the eluent used reaches 5 mL, the eluent is passed through the resin separation column at a rate of 0.75 mL / min, and the eluent is discharged into the second eluent tank at a rate of 1 mL / min. The first six-way valve is switched to port 5#, and air is used to purge the liquid in the resin separation column.

[0167] The remaining steps are the same as in Example 2.

[0168] Comparative Example 10

[0169] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0170] The difference between the steps of this comparative example and Example 2 lies in step S4. Step S4 of this comparative example is as follows: 22 mL of eluent (1 mol / L hydrochloric acid solution) is drawn from the first eluent tank at a rate of 5 mL / min from port 1# of the first six-way valve. The first six-way valve is switched to port 6#, and the second six-way valve is switched to port 1#. Before the total volume of the eluent used reaches 15 mL, the eluent is passed through the resin separation column at a rate of 0.43 mL / min. After the total volume of the eluent used reaches 15 mL, the eluent is passed through the resin separation column at a rate of 0.75 mL / min, and the eluent is discharged into the second eluent tank at a rate of 1 mL / min. The first six-way valve is switched to port 5#, and the liquid in the resin separation column is emptied using air.

[0171] The remaining steps are the same as in Example 2.

[0172] Comparative Example 11

[0173] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0174] The difference between the steps of this comparative example and those of Example 2 is that step S1 is different. Step S1 of this comparative example is: retain 0.75 mL of air at the common end C port of the first six-way valve.

[0175] The remaining steps are the same as in Example 2.

[0176] Comparative Example 12

[0177] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0178] The difference between the steps of this comparative example and Example 2 is that step S1 is different. Step S1 of this comparative example is: retain 1.3 mL of air at the common end C port near the first six-way valve.

[0179] The remaining steps are the same as in Example 2.

[0180] Comparative Example 13

[0181] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0182] The difference between the steps of this comparative example and Example 2 is that step S1 is different. Step S1 of this comparative example is: retain 1.5 mL of air at the common end C port near the first six-way valve.

[0183] The remaining steps are the same as in Example 2.

[0184] Comparative Example 14

[0185] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0186] The difference between the steps of this comparative example and those of Example 2 is that step S1 is different. Step S1 of this comparative example is: retain 0.4 mL of air at the common end C port of the first six-way valve.

[0187] The remaining steps are the same as in Example 2.

[0188] Comparative Example 15

[0189] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0190] The difference between the steps in this comparative example and those in Example 2 is that the eluent is an 8 mol / L nitric acid solution. All other steps are the same as in Example 2.

[0191] Comparative Example 16

[0192] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0193] The difference between the steps in this comparative example and those in Example 2 is that the eluent is an 8 mol / L sulfuric acid solution. All other steps are the same as in Example 2.

[0194] Comparative Example 17

[0195] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0196] The difference between the steps in this comparative example and those in Example 2 is that the eluent is a 1 mol / L nitric acid solution. All other steps are the same as in Example 2.

[0197] Comparative Example 18

[0198] This comparative example provides a method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method described in Example 1 uses a resin separation column with a volume of 1 mL and the product liquid is obtained by eluing the first 0.5-1.5 mL of the eluent.

[0199] The difference between the steps in this comparative example and those in Example 2 is that the rinsing solution is a 1 mol / L sulfuric acid solution. All other steps are the same as in Example 2.

[0200] Experimental Example

[0201] The strontium content in the eluent was determined by inductively coupled plasma atomic emission spectrometry (ICP-AES). The formula was: Strontium recovery rate = 1 - (Strontium in the eluent) / (Strontium in the eluent). 90 Sr] content / Strontium in strontium mother liquor 90 The content of Sr was calculated to obtain the strontium [ 90 Sr] recovery rate, Strontium[ 90 The detection results of Sr and Strontium 90 The recovery rate of Sr is shown in Table 1.

[0202] Table 1 Strontium [ 90 Detection results of Sr] content and Strontium [ 90 Recovery rate of Sr]

[0203] As can be seen from Table 1, strictly following the separation method of this invention can increase the strontium content [ 90 Sr] Strontium in mother liquor 90 Recovery rate of Sr.

[0204] The impurity content of the liquids in the second rinsing tank, second waste tank, and second elution tank of Examples 2 and Comparative Examples 6-10 was determined using inductively coupled plasma atomic emission spectrometry (ICP-AES). The results showed that in Example 2, Mg ≤ 6 μg / Ci, Pb ≤ 200 μg / Ci, Cu ≤ 10 μg / Ci, Fe ≤ 10 μg / Ci, Al ≤ 10 μg / Ci, and Zr ≤ 27 μg / Ci. In Comparative Examples 6 and 7, the contents of Fe, Al, and Zr were 1000 times higher than in Example 2. In Comparative Example 8, the contents of Mg, Pb, and Cu were 300 times higher than in Example 2; in Comparative Example 9, the contents of Mg, Pb, and Cu were 71 times higher than in Example 2; and in Comparative Example 10, the contents of Mg, Pb, and Cu were 210 times higher than in Example 2.

[0205] Although the principles of the present invention have been described in detail above with reference to preferred embodiments, those skilled in the art should understand that the above embodiments are merely illustrative explanations of the implementation of the present invention and are not intended to limit the scope of the present invention. The details in the embodiments do not constitute a limitation on the scope of the present invention. Any obvious changes, such as equivalent transformations or simple substitutions, based on the technical solutions of the present invention without departing from the spirit and scope of the present invention fall within the protection scope of the present invention.

Claims

1. A method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The method of Y] is characterized by, Includes the following steps: S1: Strontium-containing [ 90 The mother liquor containing strontium (Sr) was added to a resin separation column, eluted with eluent, and the strontium-containing [Sr] content was collected. 90 The eluent of Sr] is then purged from the resin separation column with air; S2: Elute with eluent and collect the yttrium-containing [ 90 The elution buffer of Y]; The total volume of the eluent used is at least 11 times the volume of the resin separation column.

2. The method for separating strontium-containing [materials] according to claim 1 90 Yttrium in mother liquor (Sr) 90 The method of Y] is characterized by, The eluent flow rate is 0.25-0.5 mL / min until the total volume of the eluent reaches 9 times the volume of the resin separation column, and the eluent flow rate is 0.5-0.75 mL / min after the total volume of the eluent reaches 9 times the volume of the resin separation column.

3. The method for separating strontium-containing [[] according to claim 1] 90 Yttrium in mother liquor (Sr) 90 The method of Y] is characterized by, The total volume of the eluent used is at least 9 times the volume of the resin separation column, and the flow rate of the eluent is 0.5-0.75 mL / min.

4. The method for separating strontium-containing [[] according to claim 1] 90 Yttrium in mother liquor (Sr) 90 The method of Y] is characterized by, The strontium-containing [ 90 The mother liquor was added in 5 portions; and / or, Each time strontium is added [ 90 The volume of the mother liquor [Sr] is 1 times the volume of the resin separation column.

5. The method for separating strontium-containing [[] according to claim 1] 90 Yttrium in mother liquor (Sr) 90 The method of Y] is characterized by, The yttrium-containing 90 Strontium of Y] 90 In the mother liquor of Sr], the strontium[ 90 Sr] and yttrium 90 The radioactivity ratio of Y] is less than 10. -5 .

6. The method for separating strontium-containing [[] according to claim 1] 90 Yttrium in mother liquor (Sr) 90 The method of Y] is characterized by, Prior to step S1, the process further includes an acid equilibration step of eluing the resin separation column with an eluent; and / or, The eluent is an 8 mol / L hydrochloric acid solution; and / or, The rinsing solution is a 1 mol / L hydrochloric acid solution.

7. The method for separating strontium-containing [materials] according to any one of claims 1-6 90 Yttrium in mother liquor (Sr) 90 The method of Y] is characterized by, The yttrium-containing [[] is discharged using the first six-way valve. 90 Strontium of Y] 90 The mother liquor, eluent, elution solution, and resin separation column are connected together, and the separated liquid is collected using a second six-way valve, including the following steps: S1: Retain 0.5 mL of air at the common port C near the first six-way valve; S:2: The eluent is transported to the resin separation column through the first six-way valve for acid equilibration, and then the acid-equilibrated liquid is collected through the second six-way valve; S3: The yttrium-containing [[] is supplied through the first six-way valve. 90 Strontium of Y] 90 The mother liquor is transported to a resin separation column for separation, and then the separated liquid is collected through the second six-way valve; S4: The rinsing liquid is transported to the resin separation column for rinsing through the first six-way valve, and the rinsed liquid is collected through the second six-way valve. Then, air is transported to the resin separation column through the first six-way valve to drain the liquid in the resin separation column. S5: The eluent is conveyed to the resin separation column for elution through the first six-way valve, and then the eluted liquid is collected through the second six-way valve, completing the elution of the yttrium-containing liquid. 90 Strontium of Y] 90 Yttrium in mother liquor [Sr] 90 Separation of Y].

8. A method for separating strontium-containing [ 90 Yttrium in mother liquor (Sr) 90 The system of Y] is characterized by, The system includes a mother liquor tank, a first rinsing tank, a second rinsing tank, a first waste liquid tank, a second waste liquid tank, a first elution tank, a second elution tank, a cleaning tank, a first six-way valve, a second six-way valve, a power unit, a separation device, and a software control device; One end of the power unit is connected to the cleaning tank, and the other end is connected to the common port C of the first six-way valve, for transporting the liquid in the mother liquor tank, the first rinsing tank, the first waste liquid tank, the first elution tank, and the cleaning tank to the separation device; The first six-way valve has port 1 connected to the first rinsing tank, port 2 connected to the mother liquor tank, port 3 connected to the first elution tank, port 4 connected to the first waste liquid tank, port 5 connected to air, and port 6 connected to the liquid inlet of the separation device. The common port C of the second six-way valve is connected to the liquid outlet of the separation device, port 1 is connected to the second waste liquid tank, port 2 is connected to the second rinsing tank, and port 3 is connected to the second elution tank. The software control device is connected to the power device, the first six-way valve, and the second six-way valve via signal connections.

9. The method for separating strontium-containing [[] according to claim 8] 90 Yttrium in mother liquor (Sr) 90 The system of Y] is characterized by, The liquid contact material of the first six-way valve and the second six-way valve is selected from either polychlorotrifluoroethylene or sapphire. The power unit is an injection pump; the liquid volume accuracy error of the injection pump is less than 1%.

10. The method for separating strontium-containing [[] according to claim 8] 90 Yttrium in mother liquor (Sr) 90 The system of Y] is characterized by, The separation device is a resin separation column; and / or, The liquid in the cleaning tank is deionized water; and / or, The liquid in the first rinsing tank is a 1 mol / L hydrochloric acid solution; and / or, The liquid in the first elution tank is an 8 mol / L hydrochloric acid solution.

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