A natural hydrating hydrogel composition, method for producing and using the same

Abstract

Use of a hydrating hydrogel composition in cosmetic applications is disclosed, comprising: a primary gel-forming component, wherein the primary gel-forming component is a water-soluble cellulose derivative, a secondary gel-forming component, wherein the secondary gel-forming component is a saccharide or a sugar alcohol with a molecular weight lower than the primary gel-forming component, which enlaces to the primary gel-forming component, and water. Hydrating hydrogel compositions and cosmetics products.

Description

[0001] A NATURAL HYDRATING HYDROGEL COMPOSITION, METHOD FOR PRODUCING AND USING THE SAME

[0002] FIELD OF THE INVENTION

[0003] The present disclosure relates to natural-based hydrating hydrogel composition, the method for producing and the cosmetic use of the same.

[0004] BACKGROUND OF THE INVENTION

[0005] Dry skin disorders, such as xerosis cutis, result from complex interactions between environmental and individual factors. Xerosis can feel tight, painful, and cause visible changes to the skin's appearance. The skin serves as a protective barrier and is divided into three main layers: the epidermis, dermis, and subcutaneous tissue. Each layer plays a crucial role in maintaining skin health and function.

[0006] The epidermis, the outermost layer of the skin, is responsible for protection against environmental factors and maintaining skin hydration. The epidermis itself consists of multiple layers, including the stratum granulosum and the stratum corneum. The outermost layer, the stratum corneum, is covered by a sebum membrane, a mixture of moisture from sweat secreted by sweat glands and sebum produced by sebaceous glands. Water in the stratum corneum is located within the hydrophilic regions of intercellular lipids and the keratin fibers of corneocytes. Abnormalities within the stratum corneum are often the primary factor exacerbating skin diseases, including xerosis and atopic dermatitis.

[0007] Clinically, xerosis cutis is observed on the outer surface of the epidermis, the stratum corneum. Corneocytes in the epidermis gradually die, and their dead cells, along with keratin fibers, move to the skin's surface as the skin wears and dries out. Keratin fibers hold skin cells together and provide resistance against external forces. A lack of water in the stratum corneum, along with the keratin fibers, is a key factor in worsening skin conditions. The absence of adequate moisture compromises the skin's barrier function, leading to increased irritation, cracking, and potential inflammation.

[0008] Topical hydration of the epidermis is often used to treat dry skin and related disorders. Moisturizers are commonly applied to increase skin hydration and restore its health and integrity. This condition is often linked to elevated skin surface pH, which can further damage the skin's barrier function. In such cases, treatment may involve the use of alkaline substances to help rebalance the skin's pH. Additionally, when the skin is subjected to physical and chemical alterations from both external and internal factors, it becomes dry, leading to deeper wrinkles and reduced elasticity due to moisture loss. These changes, associated with the deformation of skin elasticity, appear to be linked to aging and skin dryness. Among the three layers of the skin, elasticity is primarily influenced by type I collagen in the dermal layer. The elasticity of this layer is determined by the composition and density of elastin and collagen fibers that form the dermis. According to previous research, aging of skin elasticity is closely related to wrinkle formation. This relationship has been analyzed using texture characteristics to objectify information about skin wrinkles.

[0009] Moisturizers, such as ointments, creams, lotions, oils and gels, are applied to the skin to leave an oily film on the skin surface. Typical moisturizers are two-phase systems consisting of emulsions with two immiscible liquids: oil and water. The oil components in moisturizes typically include mono-, di-, and triglycerides, waxes esters, fatty acids, lanolin, and mineral oils. Lanolin, commonly used in moisturizers, is a wax secreted by the sebaceous glands of wool-bearing animals, predominantly sheep. While lanolin lacks triglycerides, it contains a mixture of esters that may cause allergic reactions in some individuals. Ointments are one-phase materials where hydrophilic compounds are miscible with water. Solids additives, such as zinc oxide, can also be added in the ointment to form a moisturizing paste.

[0010] Hydrating compounds (humectants) and moisturizing compounds are commonly used in cosmetics and skincare products. Hydrating compounds attract water to the outermost layer of the skin, while moisturizing compounds lubricate the skin and create a barrier to prevent water from escaping. Common moisturizing compounds include glycerol and hyaluronic acid. Glycerol modulates the behavior of lipids in the stratum corneum, and in cases of dry skin, glycerol may help to maintain lipid levels to preserve moisture and support the skin's barrier function.

[0011] Hydrating compounds bring water to the skin, giving a soft and elastic feel. However, this effect is temporary and lasts only until the water evaporates. Typically, hydrating products are applied first, followed by a moisturizer to lock in the moisture. Thus, one of the shortcomings of hydrating compounds is the evaporation of the water from these formulations.

[0012] Certain cosmetic products incorporate additives such as micro- and nanoplastics to influence the physical properties and handling of the product. These particles also play a role in trapping moisture in hydrating formulations for skin and hair conditioners. However, recently the cosmetic industry is becoming aware of the harmful effects of micro and nanoplastics on the environment and health, and the so-called natural cosmetics are gaining popularity.

[0013] Externally applied moisturizers and hydrating compounds are commonly used to limit water evaporation from the skin and provide a source of water molecules to hydrate the skin. The water in the stratum corneum exists in two forms: bound water and free water, depending on their mobility state. While free water can temporarily hydrate the skin, it is also more susceptible to evaporation. In contrast, bound water is strongly bound to Natural Moisturizing Factor (NMFs) in corneocytes and ceramide in intercellular lipids, and it does not evaporate.

[0014] Previous treatments for dry skin have utilized chemical compounds containing free water to increase the state of hydration of the skin, but it alone cannot sustain long-term hydration without other components to help retain it within the skin. Attempts to modify hydrating compounds with safe, natural, and low-cost ingredients that contain higher quantities of hydrogen bond-bound water, thereby prolonging and enhancing the hydrating effect and improving skin elasticity, have not yet been introduced.

[0015] EP3145548 discloses an aqueous gel composition comprising water, polysaccharides, and high molecular weight polyethylene oxide that may be used as a lubricant.

[0016] There is a need for natural hydrating compositions that effectively bring water to the skin while preventing evaporation of the formulation, thereby maintaining skin hydration for extended periods.

[0017] BRIEF DESCRIPTION OF THE INVENTION

[0018] An object of the present invention is thus to provide a natural hydrating hydrogel composition, method, and use for its cosmetic application that optimize water retention, providing enhanced hydration.

[0019] The scope of protection sought for various embodiments of the invention is set out by the independent claims. The preferred embodiments of the invention are disclosed in the dependent claims. The exemplary embodiments and features, if any, described in this specification that do not fall under the scope of the independent claims are to be interpreted as examples useful for understanding various embodiments of the invention.

[0020] According to an aspect, there is provided a use of hydrating hydrogel composition in cosmetic applications comprising: a primary gel-forming component, wherein the primary gel-forming component is a water-soluble cellulose derivative, a secondary gel-forming component, wherein the secondary gel-forming component is a saccharide or a sugar alcohol with a molecular weight lower than the primary gel-forming component, which enlaces to the primary gel-forming component, and water.

[0021] According to another aspect, there is provided a hydrating hydrogel composition comprising a primary gel-forming component, wherein the primary gel-forming component is methyl cellulose, a secondary gel-forming component, wherein the secondary gel-forming component is sucrose or xylitol, and water.

[0022] According to yet another aspect, there is provided a method for producing the hydrating hydrogel composition, comprising the steps of: providing water, providing at least one primary gel-forming component, providing at least one secondary gelforming component, mixing the primary gel-forming component with the secondary gel-forming component, and allowing the formation of a three-dimensional hydrogel network between the primary gel-forming component, the secondary gel-forming component and the water.

[0023] According to yet another aspect, there is provided a cosmetic product, comprising said composition, or the composition prepared by said method, and additive acceptable in skincare products.

[0024] BRIEF DESCRIPTION OF THE DRAWINGS

[0025] In the following the invention will be described in greater detail by means of preferred embodiments with reference to the attached drawings, in which

[0026] Figure 1 illustrates (A) water molecules, (B) secondary gel-forming component, such as sucrose or xylitol, and (C) the polymer backbones of the primary gelforming component, such as methyl cellulose, which are partially substituted with methoxy groups.

[0027] Figure 2 presents a comparison of the percentage of weight loss in terms of water loss between a regular type of hydrogel (A) and the hydrating hydrogel composition of this invention (B) with respect to days, measured at room temperature and at 90 °C.

[0028] Figure 3 represents the percentage of weight loss in terms of water loss and retention capacity of the hydrating hydrogel composition of this invention, tested at three different disaccharide concentrations.

[0029] Figure 4 represents the percentage of weight loss in terms of water loss and retention capacity of the hydrating hydrogel composition of this invention, tested at two xylitol concentrations.

[0030] Figure 5 illustrates the percentage of weight loss of the hydrating hydrogel composition with a higher amount of secondary gel-forming component (160 wt%) at physiological temperature (37°C), where it reaches a plateau at time point of 6 days.

[0031] Figure 6 illustrates a stereomicroscopic image of clinically dry skin on the surface of a finger (A) and the same skin after being hydrated with the hydrogel formed from primary and secondary gel-forming components for five minutes, then rinsed with water and dried with tissue paper (B).

[0032] Figure 7 illustrates the comparison of hydration values obtained by measuring water content through the capacitive and conductive properties in an electromagnetic field over time.

[0033] Figure 8 illustrates the comparison of skin elasticity values measured using a skin elastomer device over time.

[0034] DETAILED DESCRIPTION OF THE INVENTION

[0035] The following embodiments are exemplifying. Although the specification may refer to "an", "one", or "some" embodiment(s) in several locations of the text, this does not necessarily mean that each reference is made to the same embodiment(s), or that a particular feature only as to a single embodiment. Single features of different embodiments may also be combined to provide other embodiments. The following ex- amples are presented for further illustration of the invention without limiting the invention thereto.

[0036] It has been surprisingly found by the present inventors that combining at least a primary gel-forming component, which is a water soluble cellulose derivative, at least a secondary gel-forming component, which is a saccharide or a sugar alcohol with a molecular weight lower than the primary gel-forming component, and that enlaces to the primary gel-forming component, and water, an hydrating hydrogel composition having a desirable combination of properties for cosmetic used is obtained.

[0037] A benefit of the currently disclosed composition is its ability to increase the bound water content in the hydrating hydrogel. This enhancement reduces evaporation, thereby improving hydration capacity and increasing skin elasticity.

[0038] A hydrogel is a cross-linked hydrophilic polymer system that retains water but does not dissolve in it. In the gelation process, water is trapped within the network of the gel-forming substance, resulting in intermolecular associations among the polymer chains. Hydrogels possess unique physicochemical properties, such as swelling capacity, biocompatibility, and flexibility, which make them suitable for various biomedical applications. These applications can include drug delivery systems, wound dressings, tissue engineering scaffolds, and hydrating agents in cosmetic products, among others.

[0039] As used herein, the term "primary gel-forming component" refers to a polysaccharide. Various types of carbohydrate compounds belonging to the group of polysaccharides may be used as the primary gel-forming component. Polysaccharides are macromolecular carbohydrates composed of different monosaccharides connected by glycosidic bonds. In one embodiment, the hydrating hydrogel system may be formulated with a primary gel-forming component that is a natural based polysaccharide with an average molecular weight ranging from 10000 to 220000 Da. In another embodiment, the primary gel-forming component may be selected from cellulose, carboxymethyl cellulose (such as methyl cellulose or Citrucel), ethyl cellulose, ethyl methyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, hemicellulose, pectin, chitin or lignin.

[0040] As used herein, the term "cellulose" refers to a natural polymer with the general formula (CeHioOs)^ composed of linear chains of -D-glucopyranose units linked by P(l— >4) glycosidic bonds. Cellulose is characterized by its high molecular weight, crystalline structure, and can exist in various forms, including cellulose fibers, microfibrils, or nanocrystals. The linear structure of cellulose contains three hydroxyl groups (OH-groups) located on the carbon atoms C2, C3 and C6 of each p-D-glucopyra- nose unit. The strong hydrogen bonds between the hydroxyl groups in cellulose chains make it insoluble in water. In one embodiment, cellulose is selected as the primary gelforming component.

[0041] As used herein, the term "cellulose derivative" refers to a cellulose compound, wherein the hydroxyl groups thereof are partially or fully reacted with various substituents. One common cellulose derivative is methyl cellulose (MC) (CeH7O2(OH)x(OCHs ), in which the hydroxyl groups (OH-groups) along the cellulose backbone are substituted with methoxy groups (-OCH3). This substitution enhances the solubility of cellulose in water and enables the formation of three-dimensional networks known as hydrogels. Methyl cellulose is a well-known component of hydrogels, and its aqueous solutions exhibit thermal gelation properties. The preparation of methyl cellulose can vary depending on the degree of hydroxyl group substitution with methoxy groups. This is referred to as the degree of substitution (DS), which is defined as the average number of substituted hydroxyl groups per glucose unit in the methyl cellulose backbone. While the theoretical maximum DS is 3.0, typical DS values range from 1.3 to 2.6. Although the substitution of hydroxyl groups increases the water solubility of methyl cellulose, it simultaneously reduces the number of hydroxyl groups available to bond with water molecules. As a result, the hydrogel formed by methyl cellulose may entrap less water due to the reduced number of bonding sites. In one embodiment, a cellulose derivative is selected as the primary gel-forming component. In another embodiment methyl cellulose is selected as the primary gel-forming component.

[0042] As used herein, the term "regular type of hydrogel" refers to the hydrogel formed by methyl cellulose using a conventional method (mixed with water at elevated temperature) and containing only methyl cellulose and water. Absorbed water in these regular methyl cellulose hydrogels can exist in three states: tightly entrapped within anhydroglucose units (AGUs) via hydrogen bonds, less tightly bound, and as bulk water. The degree of substitution (DS) significantly influences the physicochemical properties of the hydrogel, including water retention in environments where evaporation (water vapor) and drying (dehydration) can occur. For these reasons, methyl cellulose hydrogels alone are not a long-lasting hydrating agent suitable for applications such as hydrating dry skin, nails, hair, pet fur, or mucosa in products like soaps and shampoos. In an embodiment, the water retention capacity against dehydration of a methyl cellulose hydrogel that is made of only primary gel-forming component, may be improved by adding molecules of high number of hydroxyl groups, i.e. secondary gel-forming component. Molecules of this kind may include the sugar molecules, which highly interact with water.

[0043] In an embodiment, there is a hydrating hydrogel composition that may be suitable for being used in skin, nails, body cavity or mucosa products, cosmetic compositions, hair shampoos, conditioners for humans and animals. The hydrating hydrogel composition has the property of hindering water evaporation from the hydrogel.

[0044] In an embodiment, the hydrating hydrogel composition may be made of natural based compounds and water in two steps. First, the primary gel-forming component, which has been chemically modified to be water soluble, is capable of forming a hydrogel when mixed with water. In the chemical modification, hydroxyl groups (OH- groups) are substituted by chemical groups, such as methoxy (methoxide, -OCH3) groups, ethoxy groups, propyl groups, hydroxypropyl groups, hydroxyethyl groups, hydroxymethyl groups, carboxyl groups and phosphate groups, which improves the solubility of the primary gel-forming component in water. Substitution lowers the number of hydrogen bonding sites available for water molecules compared to the primary gelforming component before substitution, allowing the not chemically bound bulk water to remain in the structure. Following, the second step includes that the hydrogel formed in the first step by the primary gel-forming component and water is enlaced with the secondary gel-forming component.

[0045] As used herein, the terms "enlaced" or "linked" refers to the physical or chemical connection between molecules, components, or structures in a manner that enables molecular interaction. This can encompass various types of interactions, including covalent bonding, non-covalent interactions (such as hydrogen bonding, ionic interactions, or van der Waals forces), and spatial entanglements. Such linkages can significantly influence the properties and behaviours of materials, such as their stability, water solubility, viscosity and mechanical strength. In the case of the hydrating hydrogel, the weak chemical interaction of gel-forming components play a dominant role.

[0046] As used herein, the term "secondary gel-forming component" refers to saccharides such as monosaccharides, disaccharides, oligosaccharides, polysaccharides; sugar alcohols; or other compounds that are soluble in water and have molecular weight lower than the primary gel-forming component but present more hydroxyl groups per molecule and can bind the bulk water from the primary gel. Sugar alcohols such as xylitol, erythritol and sorbitol are examples with two to four central hydroxyl groups in the molecular structure. The lower molecular weight of the secondary gelforming component enables the component to penetrate to the spaces between the primary gel-forming components by diffusion and mixing. The secondary gel-forming component has several hydroxyl groups in the chemical structure and can thus absorb water which is bound to the molecule by hydrogen bonds. Examples of secondary gelforming components of this kind include sugars such as sucrose, glucose, fructose, and maltose. These components are also known as humectants, which means that they highly interact with water.

[0047] The term "sugar" refers to soluble carbohydrates that are primarily composed of carbon, hydrogen, and oxygen atoms. Sugars are typically classified as monosaccharides, disaccharides, or oligosaccharides, depending on the number of sugar units they contain.

[0048] The term "sucrose" refers to a specific type of sugar, a disaccharide composed of one glucose molecule and one fructose molecule. In an embodiment, sucrose is chosen as the secondary gel-forming component. Sucrose allergies are very rare. The molecular weight of sucrose is 342.29 g / mol. Polar molecules of sugar, in the presence of hydroxyl groups in their molecular structure, form hydrogen bonds with water. The number of water molecules that can form hydrogen bonds with a sugar molecule depends on the number of hydroxyl groups in the sugar molecule. In the case of glucose, there are six hydroxyl groups per molecule, allowing one glucose molecule to potentially form hydrogen bonds with up to six water molecules of polar molecular structure.

[0049] The term "sugar alcohols", also known as polyols, refers to a class of polyhydric alcohols derived from monosaccharides, composed primarily of carbon, hydrogen, and oxygen atoms. Sugar alcohols are structurally similar to sugars but differ in that the carbonyl group (C=O) of a typical sugar is reduced to a hydroxyl group (-OH), conferring them with properties akin to both sugars and alcohols. Sugar alcohols such as sorbitol, xylitol, erythritol, and mannitol are commonly used in food and pharmaceuticals for their moisture-retaining and bulking properties. Xylitol, a five-carbon polyol commonly derived from xylose, with a molecular weight of 152.15 g / mol. Sugar alcohols can form hydrogen bonds with water due to their hydroxyl groups, enhancing solubility and moisture retention in formulations. Allergies to sugar alcohols are rare. The addition of the secondary gel-forming component to the hydrogel formed by the primary gel-forming component initiates a reaction with the bulk water between the polymer chains of the primary gel-forming component. This reaction forms a dense hydrogen bond network between the primary gel-forming component, the secondary gel-forming component and the water molecules. The dense hydrogen bond network entraps bulk water molecules and hinders evaporation of water from the hydrogel system, hydrating the surface on it is in contact. Furthermore, combining the primary and secondary gel-forming components allows the physical stabilization of the hydrogel system and resists phase separation during storage. As water slowly evaporates and the hydrogel dries, it reduces in size, leading to a decrease in its volume. As it shrinks, it exerts compressive stress on the surface it contacts.

[0050] In an embodiment, the primary gel-forming component and the secondary gel-forming component may be non-volatile compounds which both have hydrophilic end groups in the molecules. These hydrophilic end groups enable the molecules to bind to the underlying hydrophilic substrate through hydrogen bonds or van der Waals bonds. Tissues composed of keratin, such as skin, hair, nails and mucosa, are hydrophilic substrates. Keratin protein contains several functional groups, such as disulfide, amino, and carboxylic acid groups, making it insoluble in water. Additionally, other proteins present among the keratin proteins contribute to the tissue's ability to adsorb water. Molecules of the hydrogel containing entrapped water keep these substrates hydrated and lubricated.

[0051] In an embodiment, the hydrating hydrogel composition made from primary and secondary gel-forming components, may be supplemented with additives. As used herein, the term "additive" refers to any ingredient added to the hydrogel composition. Non-limiting examples of additives include preservation compounds, excipients, pH regulating agents, preservatives, hyaluronic acid, urea, amino acids, peptides, hydrolyzed proteins, texture modifiers, colourants, fillers, flavouring agents, vitamins, probiotics, caries-preventive agents, salts, taste / smell correcting substances, humectants, emollients, antioxidants, fragrance, colorants, texture-enhancing agents, or any mixture thereof. A person skilled in the art will readily be able to select any suitable additive according to the purpose intended and it is to be understood, that the above list is non-exhaustive and merely illustrate exemplary additives and that other additives may be used singly or in combination in a particular hydrating hydrogel composition according to the invention. In an embodiment, the hydrating hydrogel composition made from primary and secondary gel-forming components, may be supplemented with additives such as preservation substances to prolong the shelf-life of the gel and to prevent microbial growth. Preservation compounds of natural origin are preferred to avoid the presence of additional synthetic chemical compounds in the hydrating hydrogel system. In an embodiment, preservation compounds include but are not limited to potassium sorbate, benzoic acid, ethanol, benzyl alcohol, ascorbic acid, citric acid, vinegar and sodium benzoate. Additionally, other chemical compounds, such as formaldehyde-releasing compounds, chlorhexidine, iodine and parabens, can also be added to the hydrating hydrogel system to ensure to the gel remains free from contamination by microbes.

[0052] In another embodiment, the hydrating hydrogel composition made from primary and secondary gel-forming components, may be supplemented with additives such as specific biologically active substances. Biologically active substances may include antimicrobial compounds, anti-inflammatory drugs, corticosteroids, pH modifiers, fillers, perfumes and coloring agents. Biologically active substances can influence either the underlying substrate or the hydrogel itself, acting as preservation substances. Additionally, additives may also be incorporated to provide protection against UV radiation. Most commonly used include avobenzone, octinoxate, oxybenzone, titanium dioxide, and zinc oxide.

[0053] In another embodiment, the hydrating hydrogel composition made from primary and secondary gel-forming components, may be supplemented with additives such as probiotics, for use on infected skin. Probiotics are known to have beneficial effects on the skin's microflora balance and help inhibit harmful bacteria, suppressing the growth of 5. epidermidis S. aureus, C. striatum, E. coli, and M. restricta.

[0054] In hair conditioner and pet fur conditioners, the hydrogel may be enriched with cationic surfactants such as behentrimonium chloride and cetrimonium chloride. As a component in soap, shampoo and hair conditioner, the hydrating hydrogel also functions as a moisturizer.

[0055] Hydration of epithelial tissues other than skin may also benefit from hydrogel application. The moisturizing and lubricating effects of the hydrogel composition can also be applied to mucous tissues to treat dry mouth, vaginal dryness, vaginal atrophy and itching or to provide special lubrication during sexual activity. Abrasive particles may be also added to the composition to enhance the mechanical abrasive effect of the hydrogel when applied to the skin, such as particle and fiber fillers. Abrasive particles help remove the layer of dead skin cells. These particles may include sugar crystals, calcium carbonate, hydroxyapatite, carbonated apatite, bioactive glass, or silicate minerals. Examples of fibers could include cellulose fibers, microfibrillar cellulose, cellulose nanocrystals, or bioactive glass fibers.

[0056] In an embodiment, it is disclosed the use of a hydrating hydrogel composition in cosmetic applications, the hydrating hydrogel composition may comprise: a primary gel-forming component, wherein the primary gel-forming component is a water- soluble cellulose derivative, a secondary gel-forming component, wherein the secondary gel-forming component is a saccharide or a sugar alcohol with a molecular weight lower than the primary gel-forming component, which enlaces to the primary gel-forming component, and water.

[0057] In an embodiment, the use of the hydrating hydrogel composition may comprise the primary gel-forming component that may be a water-soluble cellulose derivative selected from methyl cellulose, carboxymethyl cellulose, ethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, or any mixture thereof, preferably the primary gel-forming component is methyl cellulose.

[0058] In an embodiment, the use of the hydrating hydrogel composition may comprise the secondary gel-forming component that may be saccharide or a sugar alcohol with a molecular weight lower than the primary gel-forming component selected from sucrose, glucose, fructose, galactose, mannose, lactose, maltose, xylitol, sorbitol, mannitol, erythritol, glycerin, or any mixture thereof, preferably wherein the secondary gel-forming component is sucrose or xylitol.

[0059] In an embodiment, the use of the hydrating hydrogel composition may comprise water, the primary gel-forming component, in a concentration of 1-25 wt%, preferably 3-15 wt%, more preferably 5-10 wt% as compared to water, the secondary gel-forming component, in a concentration of at least 20 wt%, preferably at least 160 wt% as compared to water.

[0060] The maximum concentration of the secondary gel-forming component is reached when the free water in the primary gel becomes supersaturated. In an embodiment, the use of the hydrating hydrogel composition may comprise the secondary gelforming component in a concentration up to 300 wt% as compared to water. In an embodiment, the use of the hydrating hydrogel composition may further comprise at least one additive selected from the group consisting of preservation compounds, excipients, pH regulating agents, preservatives, hyaluronic acid, urea, amino acids, peptides, hydrolyzed proteins, texture modifiers, fillers, flavouring agents, vitamins, probiotics, caries-preventive agents, salts, taste / smell correcting substances, humectants, emollients, antioxidants, avobenzone, octinoxate, oxybenzone, titanium dioxide, zinc oxide, fragrance, colorants, texture-enhancing agents, cationic surfactants, potassium sorbate, benzoic acid, ethanol, benzyl alcohol, ascorbic acid, citric acid, vinegar, sodium benzoate, formaldehyde-releasing compounds, chlorhexidine, iodine, parabens, sugar crystals, calcium carbonate, hydroxyapatite, carbonated apatite, bioactive glass, silicate minerals, or any mixture thereof.

[0061] In an embodiment, the use of the hydrating hydrogel composition may be capable of retaining water on hydrophilic substrates, such as skin, mucosa, hair, or nails, providing hydration and lubrication.

[0062] In an embodiment, the use of the hydrating hydrogel composition may comprise the composition that may be in the form of a paste, cream, essence, toner, emulsion, spray, salve, ointment, gel, solution, eye drops, liniment, soaps, shampoo, hair conditioner, pet fur conditioners, lotion, stick, or spray.

[0063] In an embodiment, a hydrating hydrogel composition may comprise a primary gel-forming component, wherein the primary gel-forming component is a water- soluble cellulose derivative, a secondary gel-forming component, wherein the secondary gel-forming component is sucrose in a concentration of at least 100 wt% as compared to water, and water. In another embodiment, the concentration of sucrose is up to 300 wt% as compared to water. In another embodiment, the primary gel-forming component may be methyl cellulose, preferably in a concentration of 5-10 wt% as compared to water.

[0064] In an embodiment, a hydrating hydrogel composition may comprise a primary gel-forming component, wherein the primary gel-forming component is a water- soluble cellulose derivative, a secondary gel-forming component, wherein the secondary gel-forming component is xylitol in a concentration of at least 80 wt% as compared to water, and water. In another embodiment, the concentration of xylitol is up to 300 wt% as compared to water. In another embodiment, the primary gel-forming component may be methyl cellulose, preferably in a concentration of 5-10 wt% as compared to water. In an embodiment, the previous hydrating hydrogel compositions may be used for increasing the hydration, lubrication and / or the elasticity of the tissue to which it is applied.

[0065] In an embodiment, a method for producing the previous hydrating hydrogel compositions may comprise the steps of: providing water, providing at least one primary gel-forming component, providing at least one secondary gel-forming component, mixing the primary gel-forming component with the secondary gel-forming component, and allowing the formation of a three-dimensional hydrogel network between the primary gel-forming component, the secondary gel-forming component and the water.

[0066] In an embodiment, cosmetic products may comprise the above disclosed hydrating hydrogel compositions, or the compositions prepared by the above disclosed method, and additive acceptable in cosmetic products.

[0067] In an embodiment, the cosmetic products may be used in various applications, including, for example, the manufacturing of skin creams, emulsions, lotions, gels, and oils; beauty masks, makeup (liquid, paste, and powder); makeup powders; styling powder for after bathing and body hygiene; beauty soap and deodorant soap; perfumes, eau de toilette, and colognes; bath and shower products (salts, foams, oils, and gels); depilatory products; deodorants and antiperspirants; hair products such as hair dyes and bleaches, products for molding, straightening, and setting hair, products that help maintain hairstyles, cleaning products (lotions, powders, or shampoos), conditioning products (lotions or brilliantine hair sprays), and other hairstyling products; shaving products (soaps, foams, gels, or lotions); face and eye makeup and makeupremoving products; lip products; mouth and teeth care products; nail makeup and care products; external intimate care products; sun care products; sunless tanning products; and skin whitening or anti-wrinkle products.

[0068] In an embodiment, the cosmetic products may be supplemented with an additive acceptable in cosmetic products selected from the group consisting of but not limited to preservation compounds, excipients, pH regulating agents, preservatives, hyaluronic acid, urea, amino acids, peptides, hydrolyzed proteins, texture modifiers, fillers, flavouring agents, vitamins, probiotics, caries-preventive agents, salts, taste / smell correcting substances, humectants, emollients, antioxidants, avobenzone, octinoxate, oxybenzone, titanium dioxide, zinc oxide, fragrance, colorants, texture-enhancing agents, cationic surfactants, potassium sorbate, benzoic acid, ethanol, benzyl alcohol, ascorbic acid, citric acid, vinegar, sodium benzoate, formaldehyde-releasing compounds, chlorhexidine, iodine, parabens, sugar crystals, calcium carbonate, hydroxyapatite, carbonated apatite, bioactive glass, silicate minerals, or any mixture thereof.

[0069] In an embodiment, the cosmetic products may comprise a composition in a form selected from the group consisting of paste, cream, essence, toner, emulsion, spray, salve, ointment, gel, solution, eye drops, liniment, soaps, shampoo, hair conditioner, pet fur conditioners, lotion, stick, or spray.

[0070] In the following the invention will be described in greater detail by means of preferred embodiments with reference to the attached drawings, in which

[0071] Figure 1 illustrates (A) water molecules, (B) secondary gel-forming component, such as sucrose, and (C) the polymer backbones of the primary gel-forming component, such as methyl cellulose, which are partially substituted with methoxy groups. This primary gel-forming component forms a regular type of hydrogel. The schematic drawing indicates the number of hydroxyl groups (-OH groups) for demonstration purposes but does not represent the actual number of hydroxyl groups per primary gelforming component. Water molecules bind to hydroxyl groups by hydrogen bonds.

[0072] Figure 2 presents a comparison of the percentage of weight loss in terms of water loss between a regular type of hydrogel (A) and the hydrating hydrogel composition of this invention (B) with respect to days, measured at room temperature and at 90 °C. The solid line A represents a regular type of hydrogel formed by primary gelforming component, such as methyl cellulose, while the dotted line A represents the same regular hydrogel after being dried and rehydrated. The solid line B represents the hydrogel formed when secondary gel-forming component, such as sucrose, is added to the hydrogel. The dotted line B represents the same hydrogel with secondary gel-forming component (80 wt%) after being dried and rehydrated. The regular type of hydrogel (A) loses 93% of its original water content over a 24-day dehydration period at room temperature or at 90 °C, and the remaining weight represents the original dry matter (methylcellulose). The hydrating hydrogel composition of this invention (B) shows reduced water loss in terms of weight reduction at room temperature, and the weight is reduced even more at 90 °C, showing the higher amount of bound water within the gel structure.

[0073] Figure 3 represents the percentage of weight loss in terms of water loss and retention capacity of the hydrating hydrogel composition of this invention, tested at three different disaccharide concentrations. The graph shows that, after evaporation at room temperature, the hydrogel with 160 wt% disaccharide retains more water compared to those with 120 wt% and 80 wt%. Dehydration at 90 °C causes the bound water to evaporate. The horizontal dotted lines represent the weight of "dry matter" (primary and secondary gel-forming components, such as methyl cellulose and sucrose).

[0074] Figure 4 represents the percentage of weight loss in terms of water loss and retention capacity of the hydrating hydrogel composition of this invention, tested at two xylitol concentrations. The graph shows that, after evaporation at room temperature, the hydrogel with 140 wt% xylitol retains more water compared to the one with 80 wt%. Dehydration at 90 °C causes the bound water to evaporate which drops the weight to 54 wt% and 58 wt%, respectively.

[0075] Figure 5 illustrates the percentage of weight loss of the hydrating hydrogel composition with a higher amount of secondary gel-forming component (160 wt%) at physiological temperature (37°C), where it reaches a plateau at time point of 6 days. At elevated temperatures, the bound water is released, and the weight reaches the original dry matter level (dotted line). The horizontal dotted line represents the weight of "dry matter" (primary and secondary gel-forming components, such as methyl cellulose and sucrose).

[0076] Figure 6 illustrates a stereomicroscopic image of clinically dry skin on the surface of a finger (A) and the same skin after being hydrated with the hydrogel formed from primary and secondary gel-forming components for five minutes, then rinsed with water and dried with tissue paper (B).

[0077] Figure 7 illustrates the comparison of hydration values obtained by measuring water content through the capacitive and conductive properties in an electromagnetic field (MoistureMeter, Delfin Technologies Ltd., Kuopio, Finland) over time. The hydration level was measured for both the hydrating hydrogel and a control hydration material (Novalan®, Orion Corporation, Turku, Finland) in dry skin (baseline, B). A second measurement was taken after applying the hydrogel and the control material to the skin, waiting for 5 minutes, followed by rinsing with water and drying with tissue paper, and measurements were continued over time. The figure shows that the skin hydration level was higher when the hydrating hydrogel composition was applied (solid line) compared to the control hydration material (dotted line).

[0078] Figure 8 illustrates the comparison of skin elasticity values measured using a skin elastomer device (ElastoMeter, Delfin Technologies Ltd., Kuopio, Finland) over time. The elasticity level was measured for both the hydrating hydrogel and the control hydration material in dry skin (baseline, B) and then again immediately (I) after applying both the hydrating hydrogel and the control material to the skin. After waiting for 5 minutes, the skin was rinsed with water and dried with tissue paper, and measurements were continued over time. The figure shows that the skin elasticity level was higher when the hydrating hydrogel composition was applied (solid line) compared to the control hydration material (dotted line).

[0079] EXAMPLE 1

[0080] A hydrating hydrogel composition capable of retaining water was prepared by adding methyl cellulose at a concentration of 1 - 25 wt%, preferably 7 wt%, to water at room temperature and mixed. Some of the water molecules react forming hydrogen bonds with the hydroxyl groups of the methyl cellulose molecules but the majority of the water remain as bulk water. Bulk water is entrapped by adding 20-200 wt% of sucrose, preferably 80 wt%, relative to the weight of the water, to the mixture between water and methyl cellulose. After mixing, the resulting hydrogel contains bulk water bound to the network of methyl cellulose and sucrose through hydrogen bonds. The chemical bonds retain the water molecules in the network and hinders the drying of the hydrogel as shown in Figure 2. The viscosity of the hydrogel is adjusted by the amount of methyl cellulose used. For instance, when 100 mL of water is used, 7 g of methyl cellulose is added to the water and mixed, followed by the addition of 80 g of sucrose to the water-methyl cellulose mixture. Consequently, the final hydrogel is composed of approximately 53.48% water, 3.74% methyl cellulose, and 42.78% sucrose, relative to the total 100 wt% of the hydrating hydrogel composition.

[0081] The loss of water of the hydrating hydrogel composition was measured by letting water to evaporate at 20 °C until plateau was reached on day 15. A regular type of methyl cellulose hydrogel (Figure 2A) loses all of its water content over a 15-day dehydration period, retaining only 7 % of its original weight, i.e. weight of the methyl cellulose. The evaporation of such a high quantity of water demonstrates that water in the hydrogel is less tightly bound and consists of bulk water.

[0082] When the secondary gel-forming component, such as sucrose, is added to the hydrogel (Figure 2B), the water loss is reduced: after 15 days, plateau in weight reduction at 20 °C is reached, but there is still bound water in the gel structure that can be removed by increasing the temperature to 90 °C, after which the weight drops close to the weight of the methyl cellulose and sucrose of the gel. Thus, more bulk water molecules are entrapped by hydrogen bonds to the methyl cellulose hydrogel backbone structure when additive of sucrose (disaccharide of glucose and fructose) is added to methyl cellulose hydrogel.

[0083] The hydrogen bond network formed between the primary and secondary gel-forming component and the water, increases the viscosity of the system. This network involves a large number of water molecules, which are linked through hydrogen bonds within the gel system. The dotted lines in Figure 2 show the second dehydration cycle of the same hydrogels after adding the same quantity of water that was evaporated during the first dehydration cycle (solid lines).

[0084] EXAMPLE 2

[0085] When the sucrose content of the hydrating hydrogel is increased from 80 wt% to 160 wt% relative to the original weight of the water, the water retention capacity of the hydrogel also increases (Figure 3). The dehydration profiles of the hydrogels at 20 °C reach a plateau after a period of 4 to 5 days, during which the hydrogel with 160 wt% sucrose contains more bound water than those with 120 wt% and 80 wt%. Bound water is released for evaporation at a dehydration temperature of 90 °C. The dry matter content of the hydrogels (Figure 3, dotted lines) was 63 wt% for the hydrogel with 160 wt% sucrose, 56 wt% for the hydrogel with 120 wt% sucrose, and 48 wt% for the hydrogel with 80 wt% sucrose, as measured during the dehydration period.

[0086] When xylitol is used as the secondary gel-forming component at concentrations of 80 wt% and 140 wt% (Figure 4), weight reduction by water evaporation reaches a plateau at room temperature within 3 days. When the temperature is increased to 90 °C for one day, the bound water evaporates from the hydrogel, and the weight drops to 54% and 58% of the hydrogel's original weight, respectively.

[0087] EXAMPLE 3

[0088] In in vivo conditions, the hydrating hydrogel composition is in contact with tissues at body temperature. To test the dehydration and bound water retention capacity of the hydrating hydrogel system at 37 °C, the gel was allowed to spontaneously dry for six days after a plateau was reached (Figure 5). At temperatures above 36.8 °C, the water that is bound to the polymer / molecule begins to evaporate. During the plateau phase, the weight of the hydrogel remained above the weight of the dry matter (methyl cellulose and sucrose) (dotted line), demonstrating the presence of bound water in the gel. By increasing the temperature to 90 °C, the majority of the bound water evaporated from the gel, reaching the weight of the dry matter.

[0089] EXAMPLE 4

[0090] When the hydrating hydrogel composition is applied to hydrate skin, hair, or mucosa, the water containing molecules of methyl cellulose and sucrose bind to the hydrophilic keratin fibers of the skin or the elastin fibers of mucosa through hydrogen bonds and van der Waals bonds. This retentive action of the keratin fibers and hemi- desmosomes with the primary and secondary components of the hydrogel, along with the water, allows to form a hydrating molecular layer that remains attached to the skin. Additionally, the anatomical surface structures of the skin, such as skin sulci and hair, help interlock the hydrating layer with the skin.

[0091] Figure 6 shows a microscope image of clinically dry skin on a finger (A) and the same skin after being hydrated by the hydrogel, formed with primary and secondary gel-forming components, for five minutes. The skin was then rinsed with water and dried with paper tissue (B).

[0092] Skin hydration can be measured using several techniques, such as the capacitive-impedance measurement principle, which assesses water content (moisture content) by analysing the capacitive and conductive properties of the skin in an electromagnetic field (MoistureMeter, Delfin Technologies Ltd, Kuopio, Finland). In this example, the MoistureMeter probe was first applied to dry skin (baseline) and a second measurement was taken after applying the hydrating hydrogel composition to the skin, waiting for 5 minutes, followed by rinsing with water and drying with tissue paper. The skin hydration level was higher compared to the control hydration material (Novalan®, Orion Corporation, Turku, Finland) (Figure 7).

[0093] This increased hydration level remained visible for up to 24 hours after the gel's application. Figure 7 shows the mean hydration levels of the skin on the hands of two test adults, plotted over time. From the baseline, the hydrating hydrogel increased the skin's hydration level to a range of 15 to 38, whereas the control hydratant, Novalan, only increased it to 28. The hydration level of the skin treated with the hydrating hydrogel remained elevated over the 24-hour period. Hydration testing was performed on the hand skin of two adults, with mean values recorded, and each time point involved three repeated measurements.

[0094] EXAMPLE 5

[0095] Skin elasticity, which depends on its hydration state, was measured using a skin elastomer device (ElastoMeter, Delfin Technologies Ltd, Kuopio, Finland). Elasticity was first measured at baseline, and then again after applying the hydrogel system to the skin, waiting for 5 minutes, followed by rinsing with water and drying with tissue paper. The skin's elasticity was found to be higher compared to the control hydration material (Novalan®, Orion Corporation, Turku, Finland) (Figure 8).

[0096] The residual of the hydrating hydrogel on the skin loses its free water by evaporation, and the remaining hydrogel shrinks. This shrinking causes compressive stress on the outermost layer of the skin, which enhanced its elasticity. The increased elasticity remained noticeable for up to 24 hours after using the hydrogel system. The increased elasticity remains for up to 24 hours after using the hydrogel system. Elasticity testing was performed on the hand skin of six adults, with the values in the diagram representing mean values. Each time point involved three repeated measurements.

[0097] EXAMPLE 6

[0098] A hydrating hydrogel with dermabrasive properties was prepared without the addition of traditional abrasive particles, such as calcium carbonate. Dermabrasion is used to remove layers of dead epidermis and to clean the skin mechanically. The hydrating hydrogel was produced by adding 10 wt% methyl cellulose to water, mixed and followed by the addition of 120 wt% sucrose based on the weight of the water. After the mixing, the mixture was allowed to stabilize for 3 days, during which time water molecules became entrapped by the hydroxyl (-OH) groups of the sucrose and methyl cellulose molecules.

[0099] Sucrose powder was added to the hydrogel to bring the total sucrose content to 160 wt%. Because the amount of free water is limited at the time of adding the sucrose powder, the powder particles do not dissolve, creating a two-phase system. In this system, the undissolved sucrose particles functioned as abrasive particles, making the hydrogel suitable for dermabrasion without the need for additional abrasive compounds. It will be obvious to a person skilled in the art that, as the technology advances, the inventive concept can be implemented in various ways. The invention and its embodiments are not limited to the examples described above but may vary within the scope of the claims.

Claims

CLAIMS1. Use of a hydrating hydrogel composition in cosmetic applications, wherein the composition comprises:- a primary gel-forming component, wherein the primary gel-forming component is a water-soluble cellulose derivative,- a secondary gel-forming component, wherein the secondary gel-forming component is a saccharide or a sugar alcohol with a molecular weight lower than the primary gel-forming component, which enlaces to the primary gelforming component,- and water.

2. The use of the hydrating hydrogel composition according to claim 1, wherein the primary gel-forming component is a water-soluble cellulose derivative selected from methyl cellulose, carboxymethyl cellulose, ethyl cellulose, hydroxypropyl cellulose, hydroxyethyl cellulose, or any mixture thereof, preferably wherein the primary gel-forming component is methyl cellulose.

3. The use of the hydrating hydrogel composition according to claim 1 or 2, wherein the secondary gel-forming component is a saccharide or a sugar alcohol with a molecular weight lower than the primary gel-forming component selected from sucrose, glucose, fructose, galactose, mannose, lactose, maltose, xylitol, sorbitol, mannitol, erythritol, glycerin, or any mixture thereof, preferably wherein the secondary gelforming component is sucrose or xylitol.

4. The use of the hydrating hydrogel composition according to any one of the preceding claims, wherein the composition comprises:- water,- the primary gel-forming component, in a concentration of l-25wt%, preferably 3-15wt%, more preferably 5-10 wt% as compared to water,- the secondary gel-forming component, in a concentration of at least 1 wt%, preferably 20 wt%, more preferably 80 wt%, even more preferably 160 wt% as compared to water.

5. The use of the hydrating hydrogel composition according to any one of the preceding claims, wherein the concentration of the secondary gel-forming component is up to 300 wt% as compared to water.

6. The use of the hydrating hydrogel composition according to any one of the preceding claims, wherein the composition further comprises at least one additive selected from the group consisting of preservation compounds, excipients, pH regulating agents, preservatives, hyaluronic acid, urea, amino acids, peptides, hydrolyzed proteins, texture modifiers, fillers, flavouring agents, vitamins, probiotics, caries-preventive agents, salts, taste / smell correcting substances, humectants, emollients, antioxidants, avobenzone, octinoxate, oxybenzone, titanium dioxide, zinc oxide, fragrance, colorants, texture-enhancing agents, cationic surfactants, potassium sorbate, benzoic acid, ethanol, benzyl alcohol, ascorbic acid, citric acid, vinegar, sodium benzoate, for- maldehyde-releasing compounds, chlorhexidine, iodine, parabens, sugar crystals, calcium carbonate, hydroxyapatite, carbonated apatite, bioactive glass, silicate minerals, or any mixture thereof.

7. The use of the hydrating hydrogel composition according to any one of the preceding claims, wherein the composition is capable of retaining water on hydrophilic substrates, such as skin, mucosa, hair, or nails, providing hydration and lubrication.

8. The use of the hydrating hydrogel composition according to any one of the preceding claims, wherein the composition is in the form of a paste, cream, essence, toner, emulsion, spray, salve, ointment, gel, solution, eye drops, liniment, soaps, shampoo, hair conditioner, pet fur conditioners, lotion, stick, or spray.

9. The use of the hydrating hydrogel composition according to any one of the preceding claims, wherein the composition is used for increasing the hydration, lubrication and / or the elasticity of the tissue to which it is applied.

10. A hydrating hydrogel composition, comprising:- a primary gel-forming component, wherein the primary gel-forming component is a water-soluble cellulose derivative,- a secondary gel-forming component, wherein the secondary gel-forming component is sucrose in a concentration of at least 100 wt% as compared to water,- and water.

11. The hydrating hydrogel composition according to claim 10, wherein the primary gel-forming component is methyl cellulose, preferably in a concentration of 5- 10 wt% as compared to water.

12. The hydrating hydrogel composition according to claim 10 or 11, wherein concentration of sucrose is up to 300 wt% as compared to water.

13. A method for producing a hydrating hydrogel composition according to claims 10 to 12, comprising the steps of:- providing water,- providing at least one primary gel-forming component,- providing at least one secondary gel-forming component,- mixing the primary gel-forming component with the secondary gel-forming component, and- allowing the formation of a three-dimensional hydrogel network between the primary gel-forming component, the secondary gel-forming component and the water.

14. A cosmetic product, comprising the composition according to any of the claims 10 to 12, or the composition prepared by the method according to claim 13, preferably comprising at least an additive acceptable in cosmetic products.

15. The cosmetic product according to claim 14, wherein the additive is selected from the group consisting of preservation compounds, excipients, pH regulating agents, preservatives, hyaluronic acid, urea, amino acids, peptides, hydrolyzed proteins, texture modifiers, fillers, flavouring agents, vitamins, probiotics, caries-preventive agents, salts, taste / smell correcting substances, humectants, emollients, antioxidants, avobenzone, octinoxate, oxybenzone, titanium dioxide, zinc oxide, fragrance, colorants, texture-enhancing agents, cationic surfactants, potassium sorbate, benzoic acid, ethanol, benzyl alcohol, ascorbic acid, citric acid, vinegar, sodium benzoate, for- maldehyde-releasing compounds, chlorhexidine, iodine, parabens, sugar crystals, calcium carbonate, hydroxyapatite, carbonated apatite, bioactive glass, silicate minerals, or any mixture thereof.

16. The cosmetic product according to claims 14 or 15, wherein the composition is in a form selected from the group consisting of paste, cream, essence, toner, emulsion, spray, salve, ointment, gel, solution, eye drops, liniment, soaps, shampoo, hair conditioner, pet fur conditioners, lotion, stick, or spray.

17. A hydrating hydrogel composition, comprising:- a primary gel-forming component, wherein the primary gel-forming component is a water-soluble cellulose derivative,- a secondary gel-forming component, wherein the secondary gel-forming component is xylitol in a concentration of at least 80 wt% as compared to water,- and water.

18. The hydrating hydrogel composition according to claim 17, wherein the primary gel-forming component is methyl cellulose, preferably in a concentration of 5- 10 wt% as compared to water.

19. The hydrating hydrogel composition according to claim 17 or 18, wherein concentration of xylitol is up to 300 wt% as compared to water.

20. A method for producing a hydrating hydrogel composition according to claims 17 to 19, comprising the steps of:- providing water,- providing at least one primary gel-forming component,- providing at least one secondary gel-forming component,- mixing the primary gel-forming component with the secondary gel-forming component, and- allowing the formation of a three-dimensional hydrogel network between the primary gel-forming component, the secondary gel-forming component and the water.

21. A cosmetic product, comprising the composition according to any of the claims 17 to 19, or the composition prepared by the method according to claim 20, preferably comprising at least an additive acceptable in cosmetic products.

22. The cosmetic product according to claim 21, wherein the additive is selected from the group consisting of preservation compounds, excipients, pH regulating agents, preservatives, hyaluronic acid, urea, amino acids, peptides, hydrolyzed proteins, texture modifiers, fillers, flavouring agents, vitamins, probiotics, caries-preven- tive agents, salts, taste / smell correcting substances, humectants, emollients, antioxidants, avobenzone, octinoxate, oxybenzone, titanium dioxide, zinc oxide, fragrance, colorants, texture-enhancing agents, cationic surfactants, potassium sorbate, benzoic acid, ethanol, benzyl alcohol, ascorbic acid, citric acid, vinegar, sodium benzoate, for- maldehyde-releasing compounds, chlorhexidine, iodine, parabens, sugar crystals, cal- cium carbonate, hydroxyapatite, carbonated apatite, bioactive glass, silicate minerals, or any mixture thereof.

23. The cosmetic product according to claims 21 or 22, wherein the composition is in a form selected from the group consisting of paste, cream, essence, toner, emulsion, spray, salve, ointment, gel, solution, eye drops, liniment, soaps, shampoo, hair conditioner, pet fur conditioners, lotion, stick, or spray.

Images