Liquid composition for contact lenses and contact lens product

Abstract

Disclosed are a liquid composition for contact lenses and a contact lens product, comprising: a first hydrophilic component, a second hydrophilic component, inorganic salts, and liquid water. The content of the first hydrophilic component is not greater than 1% by weight. The first hydrophilic component is a polymer having a phosphorylcholine group and having a first weight average molecular weight of not less than 4,000 Da. The content of the second hydrophilic component is not greater than 1% by weight. The second hydrophilic component is a hyaluronic acid or a salt thereof, and has a second weight average molecular weight of not greater than 10,000 Da.

Description

Liquid components for contact lenses and contact lens products Technical Field

[0001] This invention relates to a liquid composition, and more particularly to a liquid composition for contact lenses and contact lens products. Background Technology

[0002] In existing technologies, liquid components for contact lenses typically contain hydrophilic ingredients to improve lens wettability. However, these components often fail to effectively maintain lens surface moisture during prolonged wear, leading to dryness and discomfort for the wearer. While the hydrophilic ingredients added to current liquid components on the market can provide some moisturizing effect in the short term, this effect gradually weakens over time, failing to meet the needs of extended wear. Furthermore, existing technologies do not offer an effective combination of multiple components to simultaneously enhance both wettability and water retention. Therefore, there is an urgent need to develop an improved liquid component that can maintain lens wettability and comfort for extended periods during contact lens wear, reducing the occurrence of dry eye problems.

[0003] Summary of the Invention

[0004] The technical problem to be solved by the present invention is to provide a liquid composition for contact lenses and a contact lens product that addresses the shortcomings of the prior art.

[0005] To address the aforementioned technical problems, one technical solution adopted by the present invention is to provide a liquid composition for contact lenses, comprising: a first hydrophilic component, the content of which is not greater than 1% by weight, and the first hydrophilic component is a polymer having a phosphorylcholine group and having a first weight average molecular weight of not less than 4,000 Da; a second hydrophilic component, the content of which is not greater than 1% by weight, and the second hydrophilic component is hyaluronic acid or a salt thereof and having a second weight average molecular weight of not greater than 10,000 Da; an inorganic salt, the content of which is not greater than 5% by weight; and liquid water, the content of which is not less than 80% by weight.

[0006] Optionally, the first hydrophilic component is at least one of a homopolymer and copolymer having phosphocholine groups.

[0007] Optionally, the homopolymer having phosphoric acid choline groups is poly(2-methacryloyloxyethyl phosphoric acid choline); and the copolymer having phosphoric acid choline groups is formed by copolymerizing 2-methacryloyloxyethyl phosphoric acid choline with methacrylate; wherein the methacrylate is an alkyl methacrylate having C2 to C12 alkyl groups or a hydroxyalkyl methacrylate having C2 to C12 hydroxyalkyl groups.

[0008] Optionally, the first weight average molecular weight of the first hydrophilic component is between 4,000 Da and 1,000,000 Da, the second weight average molecular weight of the second hydrophilic component is less than the first weight average molecular weight, and the second weight average molecular weight is not greater than 5,000 Da.

[0009] Optionally, the first weight average molecular weight of the first hydrophilic component is between 100,000 Da and 1,000,000 Da, and the second weight average molecular weight of the second hydrophilic component is not greater than 3,000 Da.

[0010] Optionally, the second hydrophilic component is a sodium salt of hyaluronic acid or a potassium salt of hyaluronic acid.

[0011] Optionally, the second hydrophilic component is a sodium salt of hyaluronic acid, and the second weight average molecular weight of the second hydrophilic component is not greater than 1,000 Da.

[0012] Optionally, the second hydrophilic component is small molecule sodium hyaluronate or hydrolyzed sodium hyaluronate.

[0013] Optionally, based on a total weight of 100% by weight of the liquid composition for contact lenses, the content of the first hydrophilic component is between 0.005% by weight and 1% by weight, the content of the second hydrophilic component is between 0.005% by weight and 1% by weight, the content of the inorganic salts is between 0.01% by weight and 5% by weight, and the content of the liquid water is not less than 90% by weight.

[0014] Optionally, the content of the first hydrophilic component is between 0.05% by weight and 1% by weight, and the content of the second hydrophilic component is between 0.01% by weight and 0.08% by weight.

[0015] Optionally, the first weight molar concentration of the first hydrophilic component is between 1 × 10⁻⁶. -8 Moles per liter up to 2.5 × 10 -4 Between mol / L, and the second mol concentration of the second hydrophilic component is between 5 × 10⁻⁶. -7 Moles per liter to 6×10 -5 Between moles per liter.

[0016] Optionally, the inorganic salt comprises: a chloride salt and a buffer salt; wherein the chloride salt comprises at least one of sodium chloride (NaCl), potassium chloride (KCl), and magnesium chloride (MgCl2); wherein the buffer salt comprises at least one of boric acid or a salt thereof, phosphoric acid or a salt thereof, carbonic acid or a salt thereof, and citric acid or a salt thereof.

[0017] To solve the above-mentioned technical problems, another technical solution adopted by the present invention is to provide a contact lens product, which includes: a packaging container; a liquid composition for contact lenses as described above, which is filled in the packaging container; and a contact lens immersed in the liquid composition for contact lenses; wherein the contact lens is a hydrogel lens or a silicone hydrogel lens.

[0018] One of the beneficial effects of this invention is that the liquid composition for contact lenses and the contact lens product provided by this invention can significantly improve the surface wettability of contact lenses through the technical solution of "a liquid composition for contact lenses comprising: a first hydrophilic component, the content of which is not greater than 1% by weight, and the first hydrophilic component is a polymer having a phosphorylcholine group and having a first weight average molecular weight of not less than 4,000 Da" and "a second hydrophilic component, the content of which is not greater than 1% by weight, and the second hydrophilic component is hyaluronic acid or a salt thereof and having a second weight average molecular weight of not greater than 10,000 Da". In particular, the liquid composition for contact lenses of this invention can, by adding a polymer having a phosphorylcholine group and combining it with hyaluronic acid (or its salt) having a specific content and low molecular weight, achieve better wettability and water-locking and moisturizing effects on the surface of contact lenses compared to existing liquid compositions for contact lenses.

[0019] To further understand the features and technical content of the present invention, please refer to the following detailed description of the present invention. However, the detailed description provided is for reference and illustration only and is not intended to limit the present invention. Detailed Implementation

[0020] The following specific embodiments illustrate the implementation methods disclosed in this invention. Those skilled in the art can understand the advantages and effects of this invention from the content disclosed in this specification.

[0021] This invention can be implemented or applied through other different specific embodiments, and various details in this specification can also be modified and changed based on different viewpoints and applications without departing from the concept of this invention.

[0022] The following embodiments will further describe the relevant technical content of the present invention in detail, but the disclosed content is not intended to limit the scope of protection of the present invention.

[0023] It should be understood that while terms such as “first,” “second,” and “third” may be used in this document to describe various materials or parameters, these materials or parameters should not be limited by these terms. These terms are primarily used to distinguish one material from another, or one parameter from another. Furthermore, the term “or” as used in this document should, depending on the specific circumstances, include any combination of one or more related items listed.

[0024] [First Embodiment]

[0025] A first embodiment of the present invention provides a liquid composition for contact lenses, comprising: a first hydrophilic component (first moisturizing component), a second hydrophilic component (second moisturizing component), an inorganic salt, liquid water, and selectively including other additives. The liquid composition for contact lenses is particularly suitable for use as a storage solution, maintenance solution, or cleaning solution for contact lenses.

[0026] <First hydrophilic component>

[0027] The first hydrophilic component is a polymer having phosphorylcholine groups. In some embodiments of the invention, the first hydrophilic component is at least one of a homopolymer having phosphorylcholine groups and a copolymer having phosphorylcholine groups.

[0028] The homopolymer containing phosphoric acid choline groups is poly(2-methacryloyloxyethyl phosphorylcholine) (poly-MPC). The copolymer containing phosphoric acid choline groups is formed by copolymerization of 2-methacryloyloxyethyl phosphorylcholine (MPC) and methacrylic acid ester.

[0029] For example, the methacrylate may be an alkyl methacrylate or a hydroxyalkyl methacrylate.

[0030] Alkyl methacrylates have C2 to C12 alkyl groups, which can be n-butyl methacrylate (BMA), 2-ethylhexyl methacrylate (EHMA), isodecyl methacrylate (IDMA), or lauryl methacrylate (LMA).

[0031] Additionally, hydroxyalkyl methacrylates have C2 to C12 hydroxyalkyl groups, which can be 2-hydroxyethyl methacrylate (HEMA) or 2,3-dihydroxypropyl methacrylate (DHPM).

[0032] In the copolymer containing phosphoric acid choline groups, the molar number of 2-methacryloyloxyethyl phosphoric acid choline (MPC) is greater than the molar number of methacrylate, but is not limited thereto.

[0033] In one embodiment of the present invention, the first hydrophilic component (polymer having phosphoric acid choline groups) is a copolymer of 2-methacryloyloxyethyl phosphoric acid choline (MPC) and n-butyl methacrylate (BMA) (i.e., poly(MPC-co-BMA), PMB), however, the present invention is not limited thereto.

[0034] For example, the first hydrophilic component (polymer having phosphocholine groups) suitable for the present invention may include, for example, poly(MPC-co-BMA), poly(MPC-co-EMHA), poly(MPC-co-IDMA), poly(MPC-co-LMA), poly(MPC-co-HEMA), poly(MPC-co-DHPM), etc.

[0035] Furthermore, the first hydrophilic component has a first weight average molecular weight. The first weight average molecular weight (Mw1) of the first hydrophilic component (polymer having phosphocholine groups) is not less than 4,000 Da (i.e., daltons), optionally between 4,000 Da and 1,000,000 Da, and particularly preferably between 100,000 Da and 1,000,000 Da.

[0036] It is worth mentioning that the molecular weight (weight average molecular weight) mentioned in the embodiments of the present invention can be tested, for example, by a gel permeation chromatography (GPC) according to the ASTM D3593-80 standard test method, but the present invention is not limited thereto.

[0037] Based on the total weight of the liquid composition for contact lenses being 100% by weight, the content of the first hydrophilic component (polymer having phosphocholine groups) is between 0.005% by weight and 1.0% by weight (i.e., 50 to 10,000 ppm), optionally between 0.05% by weight and 1.0% by weight (i.e., 500 to 10,000 ppm), and particularly preferably between 0.1% by weight and 1.0% by weight (i.e., 1,000 to 10,000 ppm), but is not limited thereto.

[0038] <Second hydrophilic component>

[0039] Furthermore, the second hydrophilic component is hyaluronic acid or hyaluronic acid salt.

[0040] Hyaluronic acid is the same as hyaluronan. The hyaluronic acid salt can be, for example, the sodium salt of hyaluronic acid (i.e., sodium hyaluronate) or the potassium salt of hyaluronic acid (i.e., potassium hyaluronate).

[0041] Furthermore, the second hydrophilic component has a second weight average molecular weight, and the second weight average molecular weight is less than the first weight average molecular weight of the first hydrophilic component. Specifically, the second weight average molecular weight (Mw2) of the second hydrophilic component (hyaluronic acid or its hyaluronic acid salt) is not greater than 10,000 Da, preferably not greater than 5,000 Da, particularly preferably not greater than 3,000 Da, and more particularly preferably not greater than 1,000 Da.

[0042] In an optional embodiment of the present invention, the second hydrophilic component is a sodium salt of hyaluronic acid, and is a small-molecule sodium hyaluronate or hydrolyzed sodium hyaluronate (e.g., Hybloom). TM Minture, or However, the present invention is not limited thereto. The hydrolyzed sodium hyaluronate is formed by hydrolyzing sodium hyaluronate, but unlike sodium hyaluronate, the hydrolysis process involves the introduction of water and enzymes.

[0043] Based on the total weight of the liquid composition for contact lenses being 100% by weight, the content of the second hydrophilic component (hyaluronic acid or hyaluronic acid salt) is between 0.005% by weight and 1.0% by weight (i.e., 50 to 10,000 ppm), optionally between 0.01% by weight and 0.08% by weight (i.e., 100 to 800 ppm), and particularly preferably between 0.01% by weight and 0.06% by weight (i.e., 100 to 600 ppm), but is not limited thereto.

[0044] In one embodiment of the present invention, the first weight molar concentration of the first hydrophilic component (polymer having phosphocholine groups) is between 1 × 10⁻⁶. -8 Moles per liter up to 2.5 × 10 -4 The concentration of the second hydrophilic component (hyaluronic acid or hyaluronic acid salt) is between 5 × 10⁻⁶ mol / L and the second weight molar concentration of the second hydrophilic component (hyaluronic acid or hyaluronic acid salt) is between 5 × 10⁻⁶ mol / L. -7 Moles per liter to 6×10 -5 Between moles per liter.

[0045] Inorganic salts

[0046] The inorganic salts may include, for example, a chloride salt and a buffer salt.

[0047] The chloride salt can be, for example, at least one of sodium chloride (NaCl), potassium chloride (KCl), and magnesium chloride (MgCl2). Sodium chloride (NaCl) may be selected as the chloride salt. The chloride salt helps regulate the osmotic pressure of the contact lens storage solution, making it closer to the osmotic pressure of the eye's natural tears, thereby reducing eye discomfort when wearing contact lenses. It also mimics the electrolyte balance of tears, maintaining the normal physiological state of the eye surface. The content of the chloride salt is between 0.01% by weight and 5% by weight.

[0048] The buffer salts are used to adjust the pH value of the contact lens storage solution.

[0049] The buffer salt may be, for example, at least one of boric acid or a salt thereof, phosphoric acid or a salt thereof, carbonic acid or a salt thereof, or citric acid or a salt thereof. Optionally, the buffer salt may be at least one of boric acid or a salt thereof, or phosphoric acid or a salt thereof.

[0050] The boric acid or its salt may be, for example, at least one of boric acid, sodium borate, and sodium tetraborate. The phosphoric acid or its salt may be, for example, at least one of sodium dihydrogen phosphate, disodium hydrogen phosphate, potassium dihydrogen phosphate, and dipotassium hydrogen phosphate.

[0051] Based on the total weight of the liquid composition for contact lenses being 100% by weight, the content of the buffer salts is between 0.01% by weight and 5% by weight.

[0052] Liquid water

[0053] Liquid water is the solvent component (i.e., balance) of the liquid composition for contact lenses, and its content is not less than 80% by weight, optionally not less than 85% by weight, and preferably not less than 90% by weight.

[0054] It is worth mentioning that the pH value of the liquid composition for contact lenses can be selected between 6 and 8, and the osmotic pressure can be selected between 250 osmol / Kg and 450 osmol / Kg.

[0055] <Other Additives>

[0056] In some embodiments of the present invention, the liquid composition for contact lenses may further include other trace additives as needed, such as a third hydrophilic component (third moisturizing component), for example: polyvinyl alcohol (PVA), polyethylene glycol (PEG), and cellulose or its derivatives. Examples of cellulose or its derivatives include hydroxypropyl methylcellulose (HPMC), carboxymethyl cellulose (CMC), methylcellulose (MC), hydroxyethyl cellulose (HEC), or cationic cellulose derivatives.

[0057] The liquid composition for contact lenses may further include surfactants (such as DLS, SLL, SDS, SBFA 30, TWEEN 20, or Tween 80) and / or vitamins (such as vitamin B or vitamin C), which is not limited by the present invention.

[0058] [Second Embodiment]

[0059] A second embodiment of the present invention provides a contact lens product comprising: a packaging container, a liquid composition for contact lenses as described above, and a contact lens.

[0060] The packaging container may be, for example, a plastic cup, such as a polypropylene (PP) plastic cup, and the packaging container has a receiving space.

[0061] The liquid composition for contact lenses is filled in the containment space of the packaging container.

[0062] The liquid composition for contact lenses comprises: a first hydrophilic component, a second hydrophilic component, an inorganic salt, liquid water, and optionally other additives. The characteristics and proportions of each component in the liquid composition for contact lenses are as described in the first embodiment above and will not be repeated here.

[0063] The contact lens is placed in the containment space of the packaging container and immersed in a liquid composition for contact lenses. The contact lens and the liquid composition for contact lenses are jointly packaged in the packaging container, and the liquid composition for contact lenses is used to wet the contact lens and improve the surface wettability of the contact lens.

[0064] In some embodiments of the present invention, the contact lens may be, for example, a hydrogel lens or a silicone hydrogel lens.

[0065] The diameter of the contact lens lens (unit: mm) is denoted as Dia, the central base curve of the contact lens 300 (unit: mm) is denoted as BC, and the water content of the contact lens 300 is denoted as WC%. The above parameters need to meet the following conditions: (1) 13.0 < Dia < 15.0; (2) 7.0 < BC < 9.0; and (3) 30.0% < WC% < 70.0% (optional 38% - 58%).

[0066] Furthermore, the contact lens lens can be formed, for example, by curing a lens composition, and the lens composition includes: hydrophilic monomers (such as NVP, HEMA, MAA, or DMA... etc.), crosslinking agents, initiators (such as photoinitiators or thermal initiators), and optionally includes tint and silicone monomers (the composition of silicone hydrogel lenses includes silicone monomers).

[0067] [Experimental data and test results]

[0068] The following experimental data is used to elaborate on specific aspects of the present invention, enabling those skilled in the art of the present invention to implement the present invention. However, the following experimental data should not be used to limit the present invention.

[0069] <Preparation of the storage solution for contact lenses>

[0070] The following experiment is carried out by selectively adding hyaluronic acids with different molecular weights and polymers with phosphocholine groups in a buffered saline solution and conducting relevant tests.

[0071] Storage solution 1 contains: 0.708 wt% sodium chloride, 0.470 wt% boric acid, 0.05 wt% sodium borate, and the solvent (balance) is water, and no hyaluronic acid and polymers with phosphocholine groups are added. That is, storage solution 1 is the control group.

[0072] Storage solution 2 contains: 0.708 wt% sodium chloride, 0.470 wt% boric acid, 0.05 wt% sodium borate, 0.06 wt% (600 ppm) of high molecular weight hyaluronic acid (weight average molecular weight Mw is 80k - 120k Da, such as sodium hyaluronate with 100k Da), and the solvent (balance) is water, and no polymers with phosphocholine groups are added. Storage solution 2 is the comparison group.

[0073] Storage solution 3 contains: 0.708 wt% sodium chloride, 0.470 wt% boric acid, 0.05 wt% sodium borate, 0.06 wt% (600 ppm) of low molecular weight hyaluronic acid (weight average molecular weight Mw is less than 1,000 Da, such as sodium hyaluronate with 900 Da, using Hybloom TMThe solution used was a mineral (minture), and the solvent (equilibrium stock) was water, and no polymers containing phosphocholine groups were added. Preservative solution 3 served as the control group.

[0074] Preservative solution 4 contains: 0.708 wt% sodium chloride, 0.470 wt% boric acid, 0.05 wt% sodium borate, and 0.06 wt% (600 ppm) low molecular weight hyaluronic acid (weight average molecular weight Mw less than 1,000 Da, such as 900 Da sodium hyaluronate, using Hybloom). TM The solution contains 0.1 wt% (1,000 ppm) of a phosphorocholine-containing polymer (using poly(MPC-co-BMA), with a weight-average molecular weight of approximately 550,000 Da, and in poly(MPC-co-BMA), the molar ratio of MPC:BMA is approximately 3:1), and the solvent (equilibrium stock) is water. Preservative solution 4 corresponds to the experimental group of this invention.

[0075] Preservative solution 5 contains: 0.708 wt% sodium chloride, 0.470 wt% boric acid, 0.05 wt% sodium borate, 0.06 wt% (600 ppm) of ultra-high molecular weight hyaluronic acid (weight average molecular weight Mw of 850k-1,600kDa, such as sodium hyaluronate of 1,225kDa), 0.1 wt% (1,000 ppm) of a phosphocholine-containing polymer (using poly(MPC-co-BMA) as in preservative solution 4), and water as the solvent (equilibrium). Preservative solution 5 is the control group.

[0076] The addition conditions of hyaluronic acid and polymers with phosphoric acid choline groups in the above preservation solutions 1 to 5 are summarized in Table 1 below.

[0077] [Table 1]

[0078] Next, the above-prepared preservation solutions 1 to 5 were used to soak hydrogel lenses with a water content of 38%, hydrogel lenses with a water content of 58%, and silicone hydrogel lenses with a water content of 50%, respectively.

[0079] The soaking time for the lenses is approximately 12 hours, and the soaking temperature is room temperature (e.g., 25°C).

[0080] Then, the lenses after soaking were tested for wetting, including dynamic contact angle (DCA), weight loss over time, and breaking-up time (BUT). The relevant testing methods and results are as follows.

[0081] <Dynamic Contact Angle, DCA>: The dynamic contact angle of the above lens is measured using a dynamic contact angle meter and the captive bubble method to obtain the value (degrees) of the dynamic contact angle. The lower the value, the better the surface wettability.

[0082] Table 2 below shows the test results of dynamic contact angle. It lists the dynamic contact angle measurements after immersing hydrogel lenses with a water content of 38%, hydrogel lenses with a water content of 58%, and silicone hydrogel lenses with a water content of 50% in preservation solutions 1 to 5, respectively.

[0083] [Table 2]

[0084] As shown in Table 2 above, the preservation solution 4 (experimental group, containing 600 ppm of small molecule hyaluronic acid and 1,000 ppm of PMB) can give the above three types of lenses the lowest dynamic contact angle, that is, preservation solution 4 can give the above three types of lenses the best surface wettability. It is worth mentioning that preservation solution 4 can produce more significant performance for silicone hydrogel lenses, and its dynamic contact angle is reduced by at least 10 degrees compared with other preservation solution groups (e.g., from 36.12-73.77 degrees to no more than 5 degrees).

[0085] In other words, the above experiments show that adding hyaluronic acid of different molecular weights can decrease the dynamic contact angle (DCA) of the lens. Specifically, under conditions containing PMB, adding small molecular weight hyaluronic acid (Mw < 10,000 Da) (i.e., preservation solution 4) exhibits better dynamic contact angle (DCA) performance compared to adding large molecular weight hyaluronic acid (Mw 850k-1,600kDa), thus resulting in better surface wettability. Furthermore, preservation solution 4 shows more significant performance for silicone hydrogel lens groups.

[0086] <Weight loss over time>: Weight loss over time is measured by placing the lens removed from the preservation solution in an external environment (e.g., temperature 25°C and relative humidity RH 50%) and observing the weight loss over time (e.g., 15 minutes or 30 minutes). The weight loss over time is calculated as (original weight W1 of the lens removed from the preservation solution – weight W2 of the lens after a predetermined time) / (original weight W1 of the lens removed from the preservation solution), multiplied by 100%.

[0087] Table 3-1 below shows the weight loss over time of hydrogel lenses with a water content of 38% taken from different preservation solutions (preservation solutions 1 to 5).

[0088] [Table 3-1] Weight loss over time for hydrogel lenses with a water content of 38%.

[0089] The experimental results in Table 3-1 show that the hydrogel lenses with a water content of 38% soaked in the preservation solution 4 have the least weight loss over time (only 13.86% loss in 15 minutes and only 24.93% loss in 30 minutes), indicating that the preservation solution 4 provides the best moisturizing effect for hydrogel lenses with a water content of 38%.

[0090] Table 3-2 below shows the weight loss over time of hydrogel lenses with a water content of 58% taken from different preservation solutions (preservation solutions 1 to 5).

[0091] [Table 3-2] Weight loss over time for hydrogel lenses with a water content of 58%.

[0092] The experimental results in Table 3-2 show that the hydrogel lenses with a water content of 58% soaked in preservation solution 4 have the least weight loss over time (only 12.38% loss in 15 minutes and only 24.53% loss in 30 minutes), indicating that preservation solution 4 can give hydrogel lenses with a water content of 58% the best moisturizing effect.

[0093] Table 3-3 below shows the weight loss over time of silicone hydrogel lenses with a water content of 50% taken from different preservation solutions (preservation solutions 1 to 5).

[0094] [Table 3-3] Weight loss over time for silicone hydrogel lenses with a water content of 50%.

[0095] The experimental results in Table 3-3 show that silicone hydrogel lenses with a water content of 50% exhibited the least weight loss over time after soaking in preservation solution 4 (only 16.08% loss after 15 minutes and only 33.72% loss after 30 minutes), indicating that preservation solution 4 provides the best moisturizing effect for silicone hydrogel lenses with a water content of 50%. It is worth noting that preservation solution 4 has a more significant water-locking and moisturizing effect on silicone hydrogel lenses, effectively improving the wettability of the hydrophobic silicone surface.

[0096] <Time for water film to break (BUT)>: The time it takes for the water film on the lens to break after it has been removed from the preservation solution and left to stand in the external environment, observed with a camera device, is measured in seconds (s).

[0097] Table 4 below shows the time to break (BUT) test results of the water film after soaking in preservation solutions 1 to 5 for hydrogel lenses with a water content of 38%, 58%, and 50%.

[0098] [Table 4]

[0099] The experimental results in Table 4 show that the various lenses soaked in preservation solution 4 had the longest duration of water film breakage (BUT): 97 seconds for the 38% water content hydrogel lens, 107 seconds for the 58% water content hydrogel lens, and 78 seconds for the 50% water content silicone hydrogel lens. The results indicate that the various lenses soaked in preservation solution 4 have the best water-locking and moisturizing effect. In other words, the addition of small molecule hyaluronic acid and PMB with a molecular weight of less than 1,000 can effectively improve the wettability of the lens.

[0100] Overall, small-molecule hyaluronic acid has a water-retaining function, while large-molecule PMB has a water-locking function. Small-molecule hyaluronic acid carries moisture into the lens, and large-molecule PMB forms a moisturizing film on the outer layer of the lens to lock in moisture and reduce water loss. This makes the water film on the outer layer of the lens more durable, reducing dry eye problems caused by prolonged wear of contact lenses. Therefore, in preservation solution 4 (experimental group), the BUT performance of its contact lenses was better than that of the control group and other comparative groups.

[0101] The following section will continue to test the effects of different concentrations of hyaluronic acid and PMB on the dynamic contact angle (DCA) of silicone hydrogel lenses with a water content of 50%.

[0102] [Table 5-1] Experimental conditions of preservation solutions and dynamic contact angle (DCA) of silicone hydrogel lenses with 50% water content. Among them, the experimental conditions and DCA results of preservation solutions 1-5 are the same as those in Table 1 above, while the experimental conditions of preservation solutions 6-9 are new experimental conditions, which include testing the effects of different low molecular weight and concentration hyaluronic acid and PMB on the dynamic contact angle (DCA) of silicone hydrogel lenses with 50% water content.

[0103] The experimental data above show that the preservation solution contains low molecular weight hyaluronic acid with a weight average molecular weight of 1,000 to 10,000 Da and a concentration in the range of 1,000 ppm to 10,000 ppm, which can make the dynamic contact angle (DCA) of silicone hydrogel lenses with a water content of 50% relatively low (all below 45 degrees).

[0104] Among them, preservation solution 4 (experimental group) used 600ppm of hyaluronic acid with a molecular weight of 1,000ppm and 1,000ppm of PMB, and preservation solution 9 (experimental group) used 600ppm of hyaluronic acid with a molecular weight of 1,000ppm and 10,000ppm of PMB. The tested dynamic contact angles (DCA) were all less than 5 degrees, showing superior wettability.

[0105] [Beneficial Effects of the Examples]

[0106] One of the beneficial effects of this invention is that the liquid composition for contact lenses and the contact lens product provided by this invention can significantly improve the surface wettability of contact lenses through the technical solution of "a liquid composition for contact lenses comprising: a first hydrophilic component, the content of which is not more than 1% by weight, and the first hydrophilic component is a polymer having a phosphorylcholine group and having a first weight average molecular weight of not less than 4,000 Da" and "a second hydrophilic component, the content of which is not more than 1% by weight, and the second hydrophilic component is hyaluronic acid or a salt thereof and having a second weight average molecular weight of not more than 10,000 Da". In particular, the liquid composition for contact lenses of this invention can, by adding a polymer having a phosphorylcholine group and combining it with hyaluronic acid (or its salt) having a specific content and low molecular weight, have better wettability and water-locking and moisturizing effects on the surface of contact lenses compared with existing liquid compositions for contact lenses.

[0107] The above-disclosed content is only an optional and feasible embodiment of the present invention, and is not intended to limit the claims of the present invention. Therefore, all equivalent technical changes made based on the content of the present invention specification are included in the claims of the present invention.

Claims

1. A liquid composition for contact lenses, characterized in that, The liquid composition for contact lenses includes: A first hydrophilic component, the content of which is not greater than 1% by weight, and the first hydrophilic component is a polymer having a phosphorocholine group and having a first weight average molecular weight of not less than 4,000 Da. A second hydrophilic component, the content of which is not greater than 1% by weight, and the second hydrophilic component is hyaluronic acid or a salt thereof, and has a second weight average molecular weight of not more than 10,000 Da; An inorganic salt, the content of which is not more than 5% by weight; and A liquid water, the content of which is not less than 80% by weight.

2. The liquid composition for contact lenses according to claim 1, characterized in that, The first hydrophilic component is at least one of homopolymers and copolymers having phosphocholine groups.

3. The liquid composition for contact lenses according to claim 2, characterized in that, The homopolymer containing phosphocholine groups is poly(2-methacryloyloxyethyl phosphocholine); and the copolymer containing phosphocholine groups is formed by copolymerizing 2-methacryloyloxyethyl phosphocholine with methacrylate; wherein the methacrylate is an alkyl methacrylate having C2 to C12 alkyl groups or an alkyl methacrylate having C2 to C12 hydroxyalkyl groups.

4. The liquid composition for contact lenses according to claim 1, characterized in that, The first weight average molecular weight of the first hydrophilic component is between 4,000 Da and 1,000,000 Da, and the second weight average molecular weight of the second hydrophilic component is less than the first weight average molecular weight and is not greater than 5,000 Da.

5. The liquid composition for contact lenses according to claim 4, characterized in that, The first weight average molecular weight of the first hydrophilic component is between 100,000 Da and 1,000,000 Da, and the second weight average molecular weight of the second hydrophilic component is not greater than 3,000 Da.

6. The liquid composition for contact lenses according to claim 1, characterized in that, The second hydrophilic component is a sodium salt of hyaluronic acid or a potassium salt of hyaluronic acid.

7. The liquid composition for contact lenses according to claim 6, characterized in that, The second hydrophilic component is a sodium salt of hyaluronic acid, and the second weight average molecular weight of the second hydrophilic component is not greater than 1,000 Da.

8. The liquid composition for contact lenses according to claim 7, characterized in that, The second hydrophilic component is small-molecule sodium hyaluronate or hydrolyzed sodium hyaluronate.

9. The liquid composition for contact lenses according to claim 1, characterized in that, Based on the total weight of the liquid composition for contact lenses being 100% by weight, the content of the first hydrophilic component is between 0.005% by weight and 1% by weight, the content of the second hydrophilic component is between 0.005% by weight and 1% by weight, the content of the inorganic salts is between 0.01% by weight and 5% by weight, and the content of the liquid water is not less than 90% by weight.

10. The liquid composition for contact lenses according to claim 9, characterized in that, The content of the first hydrophilic component is between 0.05% by weight and 1% by weight, and the content of the second hydrophilic component is between 0.01% by weight and 0.08% by weight.

11. The liquid composition for contact lenses according to claim 1, characterized in that, The first molal concentration of the first hydrophilic component is between 1 × 10⁻⁶. -8 Moles per liter up to 2.5 × 10 -4 Between mol / L, and the second mol concentration of the second hydrophilic component is between 5 × 10⁻⁶. -7 Moles per liter to 6×10 -5 Between moles per liter.

12. The liquid composition for contact lenses according to claim 1, characterized in that, The inorganic salts comprise: a chloride salt and a buffer salt; wherein the chloride salt comprises at least one of sodium chloride (NaCl), potassium chloride (KCl), and magnesium chloride (MgCl2); wherein the buffer salt comprises at least one of boric acid or a salt thereof, phosphoric acid or a salt thereof, carbonic acid or a salt thereof, and citric acid or a salt thereof.

13. A contact lens product, characterized in that, The contact lens products include: A packaging container; A liquid composition for contact lenses according to any one of claims 1 to 12, wherein the composition is filled in the packaging container; and A contact lens, which is immersed in the liquid composition for contact lenses; wherein the contact lens is a hydrogel lens or a silicone hydrogel lens.

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