Compositions for protein stabilization and related methods
Thermally-stabilized HH collagenase compositions with polymeric and zwitterionic agents address the limitations of current wound healing treatments, providing rapid and stable debridement in various environments.
WO2026102306A1 Publication Date: 2026-05-15VITACYTE LLC
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Patent Information
- Application Number
- PCT/US2025/054629
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- Priority Date
- 2024-11-08
- Filing Date
- 2025-11-07
- Publication Date
- 2026-05-15
AI Technical Summary
Technical Problem
Current medical treatments for wound healing and debridement using crude Hathewaya histolytica (HH) collagenase are suboptimal due to slow action and inconvenient delivery formats, limiting their effectiveness in nonclinical settings and military combat situations.
Method used
Development of thermally-stabilized enzyme compositions comprising HH collagenase, a polymeric charged molecule, and a zwitterionic stabilization agent, formulated for enhanced thermal stability and suitable for spray drying or lyophilization, allowing for direct application to wounds.
Benefits of technology
The compositions provide rapid wound healing and debridement with enhanced stability, enabling effective use by first responders and in nonclinical settings without the need for medical facilities.
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Abstract
Enzymatic compositions having enhanced thermal stability comprise an enzyme, a polymeric charged molecule having a charge opposite a charge of the enzyme, and a zwitterionic stabilization agent. Methods for enhancing thermal stability of an enzyme are also provided and include steps of combining an enzyme with one or more of a polymeric charged molecules having a charge opposite a charge of the enzyme and a zwitterionic stabilization agent. Methods for treating a wound are also provided and include administering to a subject an effective amount of an enzymatic composition.
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