Method and device for generating a pattern on a surface inside an eye
A lighting device with a slide generates patterns inside the eye to detect irregularities by analyzing light distortions, providing a cost-effective and reliable method for identifying surface properties like protrusions and depressions.
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- CARL ZEISS MEDITEC AG
- Filing Date
- 2025-11-07
- Publication Date
- 2026-05-21
AI Technical Summary
Existing methods for examining the properties of the eye's surface, such as the retina, are either expensive and complex (like OCT technology) or lack accessibility, and there is a need for a cost-effective and simple method to detect irregularities like protrusions and depressions.
A method and device that uses a lighting device with a slide to refract, reflect, and absorb light inside the eye, generating a pattern on the surface to detect irregularities by projecting light patterns and analyzing the distortions caused by surface irregularities.
Enables quick, reliable, and cost-effective detection of surface irregularities, including protrusions and depressions, without interfering with visible light observation, and allows for rapid identification of imperceptible changes using machine learning.
Smart Images
Figure EP2025082354_21052026_PF_FP_ABST
Abstract
Description
[0001] 26655-CZM-PDE (C0048P-WO) 1 2024P00249WO
[0002] Method for creating a pattern on a surface inside an eye
[0003] Description
[0004] The invention relates to a method for generating a pattern on a surface inside an eye and to a pattern-generating device for generating a pattern on a surface inside an eye.
[0005] State of the art
[0006] A variety of endoillumination probes are known. These are inserted into the eye to illuminate a specific part of the eye, particularly the retina. The properties or surface of the retina can only be roughly estimated from the shadow cast by the endoillumination probe.
[0007] Optical coherence tomography (OCT) technology can generate one or more cross-sectional images of the retina to detect retinal irregularities. A disadvantage is that OCT technology is expensive and complex, meaning that not every doctor or hospital has access to an OCT device.
[0008] Disclosure of the invention
[0009] The invention is based on the objective of demonstrating a method or device by means of which a surface inside an eye can be examined cost-effectively and in a technically simple manner.
[0010] This problem is solved by a method according to claim 1. 26655-CZM-PDE (C0048P-WO) 2 2024P00249WO
[0011] In particular, the problem is solved by a method for generating a pattern on a surface inside an eye, especially for generating a pattern on at least a part of the retina, wherein the method comprises the following steps: inserting at least a part of a lighting device into the eye, wherein the lighting device is connectable to a light source for generating light and / or comprises a light source, and has a slide for generating the pattern on the surface by means of refraction and / or reflection and / or absorption of light in the slide, and emitting light through the slide onto the surface to generate the pattern on the surface.
[0012] One advantage of this is that the properties of the surface inside the eye can be determined simply and cost-effectively. In particular, irregularities or...
[0013] Irregularities in the surface, such as protrusions and / or depressions, can be detected quickly, easily, and reliably within the eye. Furthermore, the type, extent, and size of the irregularity can also be determined. In addition, the pattern can be projected or beamed onto a large surface. This allows large areas to be examined simultaneously with regard to their properties, particularly concerning irregularities, protrusions, or depressions.
[0014] The problem is also solved by a pattern-making device according to claim 11.
[0015] In particular, the problem is also solved by a pattern-generating device for generating a pattern on a surface inside an eye, in particular for generating a pattern on at least a part of the retina, wherein the pattern-generating device is designed for at least partial insertion into the eye and comprises a lighting device, wherein the lighting device is connectable to a light source for generating light and / or comprises a light source and has a slide for generating the pattern on the surface by means of refraction and / or reflection and / or absorption of light in the slide.
[0016] The advantage of this is that the device allows the properties of the surface inside the eye to be detected cost-effectively and reliably. In particular, irregularities, e.g., deviations from a spherical or 26655-CZM-PDE (C0048P-WO) 3 2024P00249WO, can be detected due to the pattern generated on the surface.
[0017] Ellipsoidal shapes, e.g. in the form of protrusions and / or depressions, can be easily and quickly identified.
[0018] According to one embodiment of the method, the light comprises or is invisible to humans, in particular incoherent light. The advantage of this is that the light from the pattern does not interfere with or negatively impair the observation of the surface using visible light. Furthermore, the incoherent light can be generated particularly cost-effectively and easily.
[0019] According to one embodiment of the method, the light comprises or is visible to humans, in particular incoherent light. An advantage of this is that the pattern or
[0020] Distortions of the pattern, for example due to unevenness, protrusions and / or depressions of the surface, can be directly or immediately recognized by a person without further technical aids.
[0021] According to one embodiment of the method, the light reflected from the surface by the pattern is received by an observation device, wherein the illumination device is moved relative to the observation device, in particular rotationally and / or translationally. An advantage of this is that the pattern or surface can be observed from different angles. Thus, the properties of the surface, e.g., protrusions and / or depressions, can be particularly well identified and determined. Furthermore, it is conceivable that the pattern is projected or generated onto the surface from different angles and / or different distances. This also increases the reliability of recognizing the properties of the surface. In particular, irregularities in the surface can be easily detected when the pattern is moved across the surface.
[0022] According to one embodiment of the method, the light received by the observation device is automatically evaluated to determine properties of the surface, in particular protrusions and / or depressions, especially by comparing the reflected light of the pattern with a target pattern, preferably by means of a machine learning system. An advantage of this is that changes in the pattern due to properties of the surface, e.g.,
[0023] Protrusions and / or depressions can be evaluated technically simply and very quickly. In particular, changes in the pattern, especially distortions or shifts, can be detected. 26655-CZM-PDE (C0048P-WO) 4 2024P00249WO
[0024] The pattern allows for the rapid identification of surface properties that are (still) imperceptible to the human eye. Consequently, protrusions and / or depressions can be detected that are not, or barely, visible to a human.
[0025] According to one embodiment of the method, the angle between the light incident on the surface and the observation device is taken into account during evaluation. This allows distortions of the pattern that arise not from properties of the surface but, for example, from the angular difference between the emission of the pattern from the lighting device and the observation device to be considered. This prevents incorrect conclusions about surface properties, such as protrusions and / or depressions, from being drawn based on such pattern distortions. This increases the reliability of determining the surface properties.
[0026] According to one embodiment of the method, imaging beam path properties of the observation device, in particular magnification by the observation device and / or imaging errors of the observation device, are taken into account during the evaluation.
[0027] This allows the properties of the surface to be detected even more reliably. Furthermore, observation devices with different optical properties can be used.
[0028] According to one embodiment of the method, the light of the pattern reflected from the surface is received by an observation device, and the light reflected from the surface received by the observation device is superimposed on a target pattern. An advantage of this is that both the projected (target) pattern on the surface and the actual (actual) pattern on the surface are superimposed on each other (e.g., on a display or in the eyepiece of an observation device), thus allowing a direct (optical) comparison. Consequently, even small distortions or deviations can be detected.
[0029] Determine human-induced shifts between the target pattern and the actual pattern, and thus infer the properties of the surface.
[0030] According to one embodiment of the method, the pattern has brighter illuminated stripes and dimmer or unilluminated stripes and / or brighter illuminated points and dimmer or unilluminated areas around the points. An advantage of the stripes is that, according to 26655-CZM-PDE (C0048P-WO) 5 2024P00249WO
[0031] Distortions caused by surface irregularities are particularly easy to spot in straight and / or parallel lines or stripes of the pattern. A further advantage of dot patterns is that they have minimal visual impact on human observation or examination of the surface.
[0032] According to one embodiment of the method, essentially no additional light is introduced into the eye besides the light provided by the slide. This allows the pattern on the surface to exhibit particularly high contrast. Consequently, distortions or shifts in the pattern can be detected with exceptional optical certainty.
[0033] According to one embodiment of the pattern-generating device, the device further comprises an observation device for receiving the reflected light of the pattern, wherein the illumination device is movable relative to the observation device. An advantage of this is that the pattern can be observed from different directions and / or the pattern can be projected onto the surface from different directions and / or distances. This allows the properties of the surface, especially irregularities, to be detected particularly reliably and quickly. Furthermore, by moving the pattern across the surface (e.g., across the retina), properties of the surface, such as protrusions and / or depressions, can be detected particularly quickly.
[0034] According to one embodiment of the pattern-generating device, the device further comprises an evaluation device for evaluating the received reflected light of the pattern to determine properties, in particular protrusions and / or depressions, of the surface, especially by comparing the reflected light of the pattern with a target pattern, preferably by means of a machine learning system. An advantage of this is that the determination of the properties can be carried out quickly. A further advantage is that changes in the pattern or differences between the actual pattern and the target pattern can be detected even when they are too small to be reliably recognized by a human. 26655-CZM-PDE (C0048P-WO) 6 2024P00249WO
[0035] According to one embodiment of the pattern-generating device, the device further comprises a display device for superimposing the reflected light of the pattern and a target pattern received by the observation device. This allows the human eye to distinguish differences between the target pattern and the pattern on the surface particularly well. Thus, even small irregularities or imperfections can be detected.
[0036] Irregularities in the surface can be detected.
[0037] According to one embodiment of the sample generation device, the slide was produced using an additive manufacturing process, in particular 3D printing. The advantage of this is that the illumination device can be manufactured particularly cost-effectively and precisely, thus making it especially economical. Consequently, the part of the illumination device inserted into the eye, or the entire illumination device, can be used only once, or only for one patient. Therefore, cleaning the illumination device after each use is unnecessary, and the device can be designed as a disposable item.
[0038] A pattern can be understood, in particular, as a structure that exhibits repeating elements. For example, individual parts of a structure can be repeated (e.g., shifted and / or rotated relative to each other) within a pattern (such as parallel stripes). It is also conceivable that the pattern has a chaotic or random structure.
[0039] The slide may in particular have three-dimensional slide structure elements through which the light is partially refracted and / or reflected and / or absorbed, and through which the light is partially transmitted essentially unchanged and in its direction of propagation essentially unaltered.
[0040] The observation device may, in particular, include or be a camera and / or a microscope, for example, a fundus microscope. It is conceivable that the illumination device includes or is the observation device. In this case, it is possible that the illumination device is not movable relative to the observation device. 26655-CZM-PDE (C0048P-WO) 7 2024P00249WO
[0041] A machine learning system can, in particular, include a neural network trained to detect distortions, shifts, or deviations of the actual pattern on the surface from a target pattern or a pattern emitted by the slide, and thereby determine the properties of the surface, especially to determine protrusions and / or depressions in the surface.
[0042] Irregularities, protrusions, or depressions can be understood as deviations from a regular shape, particularly deviations from the typically spherical or ellipsoidal shape of the surface in the eye, e.g., the retina. For example, a hole in the retina can be recognized as a depression in the retinal surface. Similarly, a retinal detachment can be recognized as an irregular separation of the retinal surface.
[0043] The target pattern can be, in particular, the pattern emitted by the slide that would appear or be visible on a flat surface or on a surface without irregularities and / or unevenness, or without protrusions and / or depressions. The actual pattern can, in particular, include or be the light received by reflection from the surface.
[0044] Preferred embodiments are described in the dependent claims. The invention is explained in more detail below with reference to drawings of exemplary embodiments. These drawings show...
[0045] Fig. 1 shows a schematic view of an exemplary embodiment of the pattern-making device according to the invention;
[0046] Fig. 2 shows a detailed view of part of the lighting device from Fig. 1;
[0047] Fig. 3 shows a schematic view of a pattern on a surface without protrusions or depressions;
[0048] Fig. 4 a schematic view of a pattern on a surface with a projection or depression; and 26655-CZM-PDE (C0048P-WO) 8 2024P00249WO
[0049] Fig. 5 shows a schematic flowchart of an exemplary embodiment of the inventive method for generating a pattern on a surface inside an eye.
[0050] In the following description, the same reference numbers are used for identical and similarly functioning parts.
[0051] Fig. 1 shows a schematic view of an exemplary embodiment of the pattern-generating device 1 according to the invention. Fig. 2 shows a detailed view of a part of the lighting device 30 from Fig. 1. Fig. 3 shows a schematic view of a pattern 70 on a surface without projections or depressions. Fig. 4 shows a schematic view of a pattern 70 on a surface with a projection or depression. Fig. 5 shows a schematic flowchart of an exemplary embodiment of the method according to the invention for generating a pattern 70 on a surface inside an eye 10.
[0052] The pattern-making device 1 comprises a lighting device 30. The lighting device 30 is at least partially insertable into an eye 10, in particular into the vitreous body of the eye 10. The lighting device 30 is connectable to, or connected to, a light source 32, or may itself have a light source 32. The connection can be made, for example, via an optical fiber 34 that guides the light from the light source 32 to the lighting device 30.
[0053] A slide 36 is arranged at the distal end of the illumination device 30, or at the end of the illumination device 30 that is inserted into the eye 10 (step 90). The slide 36 can have structural elements that refract, reflect, and / or absorb the light from the light source 32, or a portion thereof. Viewed from the light source 32, behind the slide 36, or towards the surface, the illumination device 30 can have a projection optic 38 that projects the light passing through the slide 36 onto the surface. The projection optic 38 can be connected to the slide 36 via bridges. This holds the projection optic 38 at a predetermined distance from the slide 36. The slide 36 and the projection optic 38 can be manufactured as a single piece. The Dia 36 can be fitted in one piece with the lighting device 26655-CZM-PDE (C0048P-WO) 9 2024P00249WO
[0054] The projection optics 30 may be designed as a single unit or may be interchangeable. In particular, the part of the illumination device 30 that is inserted into the eye 10 may be interchangeable. The projection optics 38 may comprise two spaced-apart lenses, in particular aspherical lenses. The slide 36 and the projection optics 38 may be made of substantially the same material, in particular a dielectric material.
[0055] Light is introduced into the illumination device 30 and at least partially transmitted through the slide 36 (step 92). This creates a pattern 70 on a surface inside the eye 10. The pattern 70 depends on the design of the respective slide 36 and / or the incident light. The pattern 70 can, for example, be created on or projected onto the retina 12 or a part of the retina 12. The retina 12, or a part of the retina 12, is then the surface on which the pattern 70 is generated.
[0056] The (emitted) pattern can be a regular pattern. Pattern 70, for example, can consist of parallel stripes and / or concentric circles and / or concentric ellipses. The stripes can be formed by illuminated or brighter / more intensely illuminated areas, while the edges of the stripes are either unilluminated or less intensely illuminated.
[0057] The projection optics 38 can be adapted so that the pattern 70 appears on a curved surface (e.g., the retina 12) in the same way as the pattern (e.g., without projection optics) would appear on a flat surface. This can mean that parallel stripes on the surface are projected in such a way that they appear parallel to each other on the curved surface.
[0058] Furthermore, it is possible that one or more stripes run at an angle (e.g., 90°) to other stripes of pattern 70. In particular, a grid structure is conceivable.
[0059] It is also conceivable that the pattern consists of 70, in particular uniformly spaced, illuminated or brightly illuminated points surrounded by unilluminated or less illuminated areas. 26655-CZM-PDE (C0048P-WO) 10 2024P00249WO
[0060] The pattern 70 can also be an unknown or random pattern. In this case, too, changes when moving the lighting device 30, especially relative to the observation device 50, can be easily detected, and thus conclusions can be drawn about the properties of the surface.
[0061] If the surface onto which the pattern 70 is projected is regular or uniform, i.e., has no protrusions and / or depressions, then the pattern 70 reflected from or visible on the surface will also be regular or uniform. For example, in a healthy retina 12 without abnormalities or irregularities, the lines of a pattern 70 comprising straight lines are essentially straight lines, as shown in Fig. 3.
[0062] If a protrusion and / or depression is present in the surface onto which the pattern 70 is projected, the pattern 70 becomes partially distorted or shifted, or a regular pattern 70 becomes irregular. With projected lines that are uniformly spaced and / or parallel to each other, the lines of the pattern are partially shifted and / or no longer run straight or parallel to each other. In Fig. 4, for example, the reflected or visible pattern 70 is shown on a surface that has a circular protrusion. The respective projected pattern (target pattern) or slide is the same in Fig. 3 and Fig. 4. The differently reflected light in Fig. 3 and Fig. 4 is due to the different properties of the surface, in particular the presence of a protrusion and / or depression.
[0063] When a pattern 70 is projected onto the inner surface of an ellipsoid (e.g., onto the retina 12), the initially parallel lines or stripes of the pattern 70 do not run completely parallel or straight on the surface (even if there are no irregularities), but are each curved. This can be taken into account, however, insofar as distortions or bends of the lines or stripes can be recognized as an indication of an irregularity. Furthermore, using a projection optic 38, the stripes can be projected parallel to each other onto the surface, so that on a regular surface (without irregularities), the lines run straight and / or parallel to each other.
[0064] Irregularities can be easily detected, particularly when moving and / or rotating pattern 70 across retina 12 or different parts of retina 12. 26655-CZM-PDE (C0048P-WO) 11 2024P00249WO
[0065] The light reflected from the surface, or the pattern 70 visible on the surface, can be detected or observed by means of an observation device 50. The observation device 50 can, for example, comprise or be a microscope, e.g., a fundus microscope. The observation device 50 is usually aligned centrally with the visual axis of the eye 10.
[0066] The light reflected from the surface can be analyzed and evaluated automatically, mechanically, or using software and / or hardware (step 94). For this purpose, the observation device 50 can include an evaluation device 52 for evaluating the received light. A comparison can then be made between the target pattern and / or the (known) emitted pattern 70 and the pattern 70 visible on the surface. In particular, distortions and / or shifts of the pattern 70 can be detected.
[0067] A suitably trained machine learning system can be used for analysis and comparison. Alternatively, pattern 70 could be unknown and moved across retina 12, thereby detecting irregularities or unevenness in the surface.
[0068] The illumination device 30 can be moved relative to the observation device 50 and / or relative to the eye 10. The movement can be translational and / or rotational.
[0069] This can mean that the end of the illumination device 30 is moved laterally within the eye 10 (for example, without moving the illumination device 30 further out of or further into the eye 10), i.e., the angle between the illumination device 30 and the eye 10, or the pupil, or the visual axis is changed. It is also conceivable (alternatively or additionally) that the illumination device 30 is moved further into and / or further out of the eye 10. In this case, the pattern 70 is moved, i.e., the pattern 70 is projected onto a different surface or part of the retina 12 and / or projected onto the surface from a different angle. 26655-CZM-PDE (C0048P-WO) 12 2024P00249WO
[0070] Alternatively or in addition to the movement(s) described, the lighting device 30 or the end of the lighting device 30 and / or the slide 36 can be rotated in the eye 10. This can be done manually or automatically.
[0071] This allows the properties of the surface to be determined particularly effectively. In particular, one or more protrusions and / or one or more depressions in the surface can be identified.
[0072] The properties of a surface can include, in particular, deviations from its regularity, e.g., in the form of depressions / defects and / or protrusions / protrusions and / or irregularities. Even a curved surface, e.g., the retina, may exhibit essentially no or only very slight irregularities if it is healthy.
[0073] For example, by detecting irregularities or unevenness, a retinal detachment can be identified, as the retina 12 then does not run smoothly or has a uniform shape, but rather exhibits one or more protrusions on a portion of it, having detached from the rest of the eye. Similarly, the introduction or injection of fluid into the subretinal area behind the retina 12 can be monitored, as the pattern 70 indicates that a protrusion forms in the retina 12, or that the retina 12 is displaced at a certain point or area further towards the observation device 50 than the surrounding area. Drainage of fluid from the affected area can also be observed or detected, as any existing protrusion will then shrink or disappear.
[0074] The degree of point / stripe displacement and / or distortion of pattern 70 typically correlates with the size (width, height and depth) of the irregularity or protrusion or depression of the area.
[0075] The change in pattern 70 when the lighting device 30 is moved relative to the observation device 50 or relative to the eye 10 can also be analyzed and evaluated manually and / or mechanically or automatically. 26655-CZM-PDE (C0048P-WO) 13 2024P00249WO
[0076] The emitted pattern 70, or target pattern, can be superimposed on the reflected light from the surface. For example, the observation device 50 can display the pattern 70 as it appears on the surface, with the emitted pattern or target pattern superimposed on it. Alternatively, it can show how the pattern 70 would appear on a healthy, normal, or regular retina 12. This makes it particularly easy to detect small changes in the pattern 70. The superimposition can be performed optically, for example, in an observation beam path of the observation device 50, and / or displayed on a monitor, screen, or display device 60. The superimposition can be switched on and off manually or automatically (e.g., time-controlled, changing every second).The overlay can also be saved as a marker and retrieved later.
[0077] Here, deviations between the target pattern (the emitted pattern or the pattern as it would appear on a surface without unevenness / irregularities) and the actual pattern (the pattern as it is actually seen, or the light reflected from the surface) can be detected by software and / or hardware. The respective area where a deviation or difference exists can be highlighted in color in the display. It is also conceivable that different color values or colors could be used, depending on the magnitude of the deviation between the target and actual patterns. One or more threshold values can be used to determine whether a deviation between the target and actual patterns exists. A machine learning system can be used for this purpose.
[0078] It is also conceivable that the detected protrusion and / or depression in the surface is simulated or virtually represented. This means, for example, that the outlines of the protrusion or depression in the surface are highlighted in color.
[0079] The light may include or be visible light. It is conceivable that the illumination device 30 is used as an illumination probe or as the sole illumination probe in the eye 10, i.e., for a possible operation on or examination of the eye 10, no additional illumination probe needs to be inserted into the eye 10. It is conceivable that by means of Chandelier- 26655-CZM-PDE (C0048P-WO) 14 2024P00249WO
[0080] Illumination and / or additional light is introduced into the eye 10 by means of transpupillary illumination.
[0081] Alternatively or additionally to visible light, light invisible to humans, e.g., infrared light, can be used. This does not negatively impair the optical observation of the inside of the eye by humans, and simultaneously, the reflected light can be captured using an infrared camera and then displayed to the human (e.g., on a monitor or, so to speak, transformed into visible light in the beam path of the observation device 50).
[0082] When analyzing the reflected light, the difference in the angle between the incident light (illumination device 30) and the observation device 50 (receiving the reflected light) can be taken into account mathematically or computationally, e.g., triangulation. The imaging ray path (e.g., magnification, aberrations) of the observation device 50 can also be considered.
[0083] Dia 36, which produces pattern 70, is usually introduced into eye 10.
[0084] The optical fiber 34 can be or comprise an optical fiber. The optical fiber can have a core diameter of, for example, up to 400 pm, and various numerical apertures (e.g., NA0.1–NA0.8) can be used. This allows, for example, calibration sizes between 23G and 27G. Sizes larger than 27G, for example up to 32G, are also conceivable.
[0085] The light source 32 may include or be an LED light source and / or a LARP light source (Laser Activated Remote Phosphor light source).
[0086] The light can be incoherent. Pattern 70 is generated by slide 36 (and any projection optics 38 that may be present). The light can be white light. 26655-CZM-PDE (C0048P-WO) 15 2024P00249WO
[0087] Reference symbol list
[0088] 1 Pattern-making device
[0089] 10 Eye
[0090] 12 Retina
[0091] 30 Lighting device
[0092] 32 Light source
[0093] 34 fiber optic cables
[0094] 36 slides
[0095] 38 Projection optics
[0096] 50 observation device
[0097] 52 Evaluation device
[0098] 60 Display device
[0099] 70 samples
[0100] Step 90: Inserting at least part of a lighting device into the eye. Step 92: Emitting light through the slide.
[0101] Step 94 of the automated evaluation of the light received by the observation device
Claims
26655-CZM-PDE (C0048P-WO) 16 2024P00249WO Claims 1. Method for generating a pattern (70) on a surface inside an eye (10), in particular for generating a pattern (70) on at least a part of the retina (12), the method comprising the following steps: Inserting at least part of a lighting device (30) into the eye (10) (90), wherein the lighting device (30) - is connectable to a light source (32) for generating light and / or includes a light source (32), and - a slide (36) for generating the pattern (70) on the surface by means of refraction and / or reflection and / or absorption of light in the slide (36), and Radiating light through the slide (36) onto the surface to create the pattern (70) on the surface (92).
2. The method of claim 1, wherein Light includes or is light that is invisible to humans, especially incoherent light.
3. Method according to claim 1 or 2, wherein light includes or is light visible to humans, especially incoherent light.
4. Method according to any one of the preceding claims, wherein the light reflected from the surface of the pattern (70) is received by an observation device (50), wherein the illumination device (30) is moved relative to the observation device (50), in particular rotationally and / or translationally.
5. Method according to any one of the preceding claims, wherein The light received by one or the observation device (50) is automatically evaluated to determine properties, in particular protrusions and / or depressions, of the surface, in particular by comparing the reflected light of the pattern (70) with a target pattern, preferably by means of a machine learning system. 26655-CZM-PDE (C0048P-WO) 17 2024P00249WO 6. Method according to claim 5, wherein the angle between the light incident on the surface and the observation device (50) is taken into account during the evaluation.
7. Method according to claim 5 or 6, wherein Imaging beam path properties of the observation device (50), in particular a magnification by the observation device (50) and / or imaging errors of the observation device (50), are taken into account during the evaluation.
8. Method according to any one of the preceding claims, wherein the light reflected from the surface of the pattern (70) is received by one or the observation device (50) and the light reflected from the surface received by the observation device (50) is superimposed on a target pattern.
9. Method according to any one of the preceding claims, wherein the pattern (70) has brighter illuminated stripes and less bright or unilluminated stripes and / or brighter illuminated spots and less bright or unilluminated areas around the spots.
10. Method according to any one of the preceding claims, wherein In addition to the light introduced by the slide (36), essentially no further light is introduced into the eye (10).
11. Pattern-generating device (1) for generating a pattern (70) on a surface inside an eye (10), in particular for generating a pattern (70) on at least a part of the retina (12), wherein the pattern-generating device is designed for at least partial insertion into the eye (10) and comprises a lighting device (30), wherein the lighting device (30) - is connectable to a light source (32) for generating light and / or includes a light source (32) and - a slide (36) for generating the pattern (70) on the surface by means of refraction and / or 26655-CZM-PDE (C0048P-WO) 18 2024P00249WO Reflection and / or absorption of light in the slide (36).
12. Pattern-making device according to claim 11, further comprising an observation device (50) for receiving the reflected light of the pattern (70), wherein the illumination device (30) is movable relative to the observation device (50).
13. Pattern generation device according to claim 11 or claim 12, further comprising an evaluation device (52) for evaluating the received reflected light of the pattern (70) for determining properties, in particular protrusions and / or depressions, of the surface, in particular by comparing the reflected light of the pattern (70) with a target pattern, preferably by means of a machine learning system.
14. Pattern-generating device according to claim 12 or claim 13, further comprising a display device (60) for superimposing the reflected light of the pattern (70) and a target pattern received by the observation device (50).
15. Pattern-making device according to one of claims 11-14, wherein the slide (36) was produced using an additive manufacturing process, in particular using 3D printing.