Low silica content sol-GEL bioactive glass that remains amorphous

A sol-gel method using alkali metal nitrites and controlled stabilization produces amorphous silicate glass with high surface area and mesoporous structures, addressing synthesis challenges and enhancing bioactivity for wound healing and bone regeneration.

WO2026115162A1PCT designated stage Publication Date: 2026-06-04IMPERIAL COLLEGE INNVOATIONS LTD
View PDF 4 Cites 0 Cited by

Patent Information

Authority / Receiving Office
WO · WO
Patent Type
Applications
Current Assignee / Owner
Filing Date
2025-11-28
Publication Date
2026-06-04

AI Technical Summary

Technical Problem

Existing methods for synthesizing sol-gel-derived alkali metal-containing bioactive glass often result in crystalline glass-ceramics or compositions that deviate from the target composition, leading to decreased bioactivity, cracking, and regulatory approval issues, while melt-derived bioactive glass cannot produce fibrous morphologies without crystallization.

Method used

A sol-gel method using alkali metal nitrites and controlled stabilization at temperatures below 500°C in an inert atmosphere or reduced pressure to produce amorphous silicate glass with mesoporous structures and various morphologies, including fibres, powders, and granules, maintaining the compositions of S53P4 and 45S5 for bioactivity.

Benefits of technology

The method produces amorphous silicate glass with high surface area and controlled pore diameter, enhancing bioactivity and dissolution rates, suitable for wound healing and bone regeneration, while avoiding crystallization and regulatory approval challenges.

✦ Generated by Eureka AI based on patent content.

Smart Images

  • Figure IMGF000014_0001
    Figure IMGF000014_0001
  • Figure IMGF000014_0002
    Figure IMGF000014_0002
  • Figure IMGF000022_0001
    Figure IMGF000022_0001
Patent Text Reader

Abstract

The present invention relates to an amorphous silicate glass (for example, a glass fibre). The glass may comprising one or more alkali metals selected from sodium, lithium, and potassium, for example sodium, lithium, and potassium oxide. The glass may comprise pores wherein the modal pore diameter is from about 2 to about 50 nm. The present invention also relates to methods of preparing said glasses and uses thereof.
Need to check novelty before this filing date? Find Prior Art

Citation Information

Patent Citations

  • Ultrathin porous glass membrane, for membrane applications produced by slicing a heat treated silica-rich sodium borosilicate glass block into thin plates, followed by acid and then alkali extraction

    DE19848377A1

  • Bioactive glass compositions

    EP3778506A1

  • Composite materials using bone bioactive glass and ceramic fibers

    US6121172A

  • Use of bioactive glass compositions to stimulate osteoblast production

    WO2002004606A1