Low silica content sol-GEL bioactive glass that remains amorphous
A sol-gel method using alkali metal nitrites and controlled stabilization produces amorphous silicate glass with high surface area and mesoporous structures, addressing synthesis challenges and enhancing bioactivity for wound healing and bone regeneration.
Patent Information
- Authority / Receiving Office
- WO · WO
- Patent Type
- Applications
- Current Assignee / Owner
- IMPERIAL COLLEGE INNVOATIONS LTD
- Filing Date
- 2025-11-28
- Publication Date
- 2026-06-04
AI Technical Summary
Existing methods for synthesizing sol-gel-derived alkali metal-containing bioactive glass often result in crystalline glass-ceramics or compositions that deviate from the target composition, leading to decreased bioactivity, cracking, and regulatory approval issues, while melt-derived bioactive glass cannot produce fibrous morphologies without crystallization.
A sol-gel method using alkali metal nitrites and controlled stabilization at temperatures below 500°C in an inert atmosphere or reduced pressure to produce amorphous silicate glass with mesoporous structures and various morphologies, including fibres, powders, and granules, maintaining the compositions of S53P4 and 45S5 for bioactivity.
The method produces amorphous silicate glass with high surface area and controlled pore diameter, enhancing bioactivity and dissolution rates, suitable for wound healing and bone regeneration, while avoiding crystallization and regulatory approval challenges.
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