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31 results about "3-phenylpropanoic acid" patented technology
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Phenylpropanoic acid or hydrocinnamic acid is a carboxylic acid with the formula C9H10O2 belonging to the class of phenylpropanoids. It is a white, crystalline solid with a sweet, floral scent at room temperature. Phenylpropanoic acid has a wide variety of uses including cosmetics, food additives, and pharmaceuticals.
Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, method of making and use thereof
ActiveUS20110002991A1Lower potentialReduce addictionBiocideNervous disorder3-phenylpropanoic acidEpoxy
The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
Owner:KEMPHARM INC
Substituted phenylpropionic acid derivatives as agonists to human peroxisome proliferator-activated receptor (PPAR) alpha
InactiveUS6506797B1Improve securityHigh binding activityBiocideOrganic chemistry3-phenylpropanoic acidAcid derivative
The invention provides novel substituted phenylpropanoic acid derivatives that activate by binding to receptor as ligands of human peroxisome preliferant-activated receptor alpha (PPARalpha), and exhibit potent decreasing action on lipids in blood (cholesterol and triglyceride).It relates to a substituted phenylpropanoic acid derivatives represented by a general formula (1),their pharmaceutically acceptable salts and their hydrates, and processes for preparing them.
Owner:KYORIN PHARMA CO LTD
Novel phenylpropionic acid derivatives as peroxisome proliferator-activated gamma receptor modulators, method of the same, and pharmaceutical composition comprising the same
InactiveUS20100063041A1Effective preventionEffective treatmentBiocideOrganic chemistryDisease3-phenylpropanoic acid
The present invention provides a novel phenylpropionic acid derivative and a PPAR-γ modulator comprising the same as an active ingredient. The phenylpropionic acid derivative of the present invention has modulatory action on function of PPAR-γ and then exhibits hypoglycemic, hypolipidemic and insulin resistance-reducing effects on PPAR-mediated diseases or disorders. Therefore, the present invention is prophylactically or therapeutically effective for diabetes and metabolic diseases.
Owner:DONG A PHARMA +1
Phenylethanoic acid, phenylpropanoic acid and phenylpropenoic acid conjugates and prodrugs of hydrocodone, method of making and use thereof
The presently described technology provides phenylethanoic acid, phenylpropanoic acid, phenylpropenoic acid, a salt thereof, a derivative thereof or a combination thereof chemically conjugated to hydrocodone (morphinan-6-one, 4,5-alpha-epoxy-3-methoxy-17-methyl) to form novel prodrugs or compositions of hydrocodone which have a decreased potential for abuse of hydrocodone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
Owner:ZEVRA THERAPEUTICS INC
Phenylpropionic acid derivative and use thereof
InactiveUS20100093819A1Strong inhibitory activityGood treatment effectBiocideSenses disorder3-phenylpropanoic acidHydrogen atom
A compound represented by the following general formula (1) or a salt thereof, which has superior inhibitory activity against type 4 PLA2, and thus has prostaglandin and / or leucotriene production suppressing action [X represents a halogen atom, an alkyl group which may be substituted, or the like, Y represents hydrogen atom or an alkyl group which may be substituted, and Z represents hydrogen atom or an alkyl group which may be substituted].
Owner:ASAHI KASEI PHARMA
Pyrimidine substituted benzenepropanoic acid derivative, its preparation method and use in curing polycystic kidney disease
ActiveCN101054372ATranscriptional activityGood treatment effectOrganic active ingredientsOrganic chemistry3-phenylpropanoic acidGeometric isomer
The present invention relates to a kind of pyrimidine substituted phenylpropionic acid derivative compounds of formula I which includes itsgeometric isomer, enantiomer, diastereoisomer, racemate, and mixture therefore or pharmaceutically acceptable salt thereof. The present invention also relates to the preparation method and use of such compound. Compounds of present invention are useful in the treatment of polycystic kidney disease.
Owner:SHENYANG SUNSHINE PHARMA
Splitting method for racemic 2-benzene propanoic acid
InactiveCN103113211ATo achieve the purpose of separationCarboxylic compound separation/purification3-phenylpropanoic acidBenzene
The invention discloses a splitting method for racemic 2-benzene propanoic acid. The splitting method comprises the following steps: using an organic solvent A, an organic solvent B and a phosphate buffer solution containing hydroxypropyl-beta-cyclodextrin to constitute a solvent system according to the volume ratio of 1-8: 2-6: 10, uniformly mixing, and standing for stratification to get an organic phase and a water phase; dissolving racemic 2-benzene propanoic acid with the obtained water phase to prepare a sample; and splitting racemic 2-benzene propanoic acid by adopting high-speed counter-current chromatography, separating a prepeak eluate and a postpeak eluate, and recovering to get levo-2-benzene propanoic acid monomer and dextro-2-benzene propanoic acid monomer. By adopting the method disclosed by the invention to split racemic 2-benzene propanoic acid, the higher separation degree can be achieved; and the method is further suitable for various types of preparation type counter-current chromatographic instruments, and the levo-2-benzene propanoic acid monomer and the dextro-2-benzene propanoic acid monomer can be obtained by separation.
Owner:ZHEJIANG UNIV OF TECH
Improved preparation method of Nagelinei
InactiveCN1517335AResolve incomplete responsesReduce usageOrganic compound preparationMetabolism disorderPhenylalanineTetrahydrofuran
An improved process for preparing 'Nagelienai' features that the p-isopropylbenzoic acid is reduced by the reducer chosen from active Ni and active Pd or Pd-C to become 4-isopropylcyclohexaformic acid, or the mixture of cis-and anti-4-isopropylcyclohexaformic acids are converted to anti-isopropylcyclohexaformic acid under the action of hydroxide of alkali metal, or the anti-4-isopropylcyclohexacyl chloride reacts on D-phenylpropanoic acid in a mixed solvent system, or the Nagelienai from previous step is recrystallized prification in the mixed organic solvent, and the any two, three, or four of above-said steps are combined.
Owner:INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
Method for efficiently synthesizing beta-benzyl butyrolactone having specific configuration
ActiveCN105175365ARaw materials are cheap and easy to getShort stepsOrganic chemistry3-phenylpropanoic acidChemical synthesis
The present invention discloses a method for efficiently synthesizing beta-benzyl butyrolactone having a specific configuration. The method is characterized in that phenylpropionic acid or a derivative thereof is adopted as a starting material, the phenylpropionic acid or the derivative thereof and an oxazolidone chiral prosthetic group are subjected to condensation, a haloacetic acid ester attacks the carbonyl ortho position carbon of the phenylpropionic acid under the effect of a large steric hindrance organic alkali, the prosthetic group is hydrolyzed and recovered after the specific chiral center is successfully constructed, and the corresponding product is subjected to an intramolecular ester exchange reaction to generate the beta-benzyl butyrolactone having the specific configuration. According to the present invention, the prepared beta-benzyl butyrolactone can be used for chemical synthesis of a lot of dibenzyl type lignins having potential medicinal values, and has characteristics of cheap and readily available raw materials, short step, high yield, and high optical purity.
Owner:LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
Phenylpropanoic acid derivatives
InactiveUS20070155808A1High activityEasy to useBiocideNervous disorderDiabetes mellitus3-phenylpropanoic acid
The present invention provides a novel compound having a GPR40 receptor function modulating action, which is useful as an insulin secretagogue, a drug for the prophylaxis or treatment of diabetes and the like. A compound represented by the formula (I) wherein each symbol is as defined in the specification, a salt thereof and a prodrug thereof have unexpectedly superior GPR40 receptor agonist activity and also show superior properties as a pharmaceutical product, such as stability and the like. Thus, they can be safe and useful drugs for the prophylaxis or treatment of GPR40 receptor related conditions or diseases in mammals.
Owner:TAKEDA PHARMA CO LTD
Electrochemical synthesis method of 2-phenylpropionic acid with optical activity
InactiveCN103789791AEfficient use ofEfficient synthesisElectrolysis componentsElectrolytic organic productionN dimethylformamideSynthesis methods
The invention discloses an electrochemical synthesis method of 2-phenylpropionic acid with optical activity. The method is characterized by comprising the following steps: mixing 1-chlorine-1-phenylethane with N, N-dimethylformamide or acetonitrile and tetraalkylammonium salt to form an electrolyte solution, by taking a chiral schiff base cobalt complex as a catalyst, carrying out electric carboxylation reaction in the presence of normal pressure saturated carbon dioxide by using constant current or constant potential, carrying out rotary evaporation and extraction on the electrolytic reaction liquid to obtain the 2-phenylpropionic acid with the optical activity. Compared with the prior art, the method disclosed by the invention is simple in process and convenient in operation and has the advantages that the greenhouse-effect gas carbon dioxide can be effectively utilized and the atmospheric pollution is reduced; in the meantime, the conversion of aromatic chlorides and the effective synthesis of chiral matters are realized; the raw materials are low in price and easily available, so that the method is low in cost; a new way is created for the research on the green synthesis of organic matters such as aromatic carboxylic acid derivatives; the method particularly shows an excellent application prospect in the fields of agriculture and drug synthesis and is a process route with great industrial synthesis value.
Owner:EAST CHINA NORMAL UNIV
Cinnamic, phenylpropiolic and phenylpropanoic acid derivatives useful as anti-tumour agents
Cinnamic and phenylpropiolic acid derivatives of Formula (I) having antitumour and chemosensitizing activity are described. Also described are pharmaceutical compositions containing the above-mentioned compounds, for the treatment of tumours.
Owner:SIGMA TAU IND FARMACEUTICHE RIUNITE SPA
Method for removing ethanol, isopropanol and octyl alcohol from amino resin workshop wastewater
InactiveCN105084495AStrong complexing abilityFast precipitationWater contaminantsNature of treatment waterOctanolAcetophenone
The invention relates to a method for removing ethanol, isopropanol and octyl alcohol from amino resin workshop wastewater. The components adopted by the method comprises 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane, 1,8-dihydroxy-3-methoxy-6-methylanthraquinone, S(-)-2-amino-6-n-propyle-4,5,6,7-tetrahydrobenzothiazole dihydrochloride, 4-octylphenol ethoxylate, 3',4'-dihydoxy-2-(methylamino)acetophenone hydrochloride, 4-acetoxy-3-methoxy-(2-propenyl) benzene, 4-methoxybenzyl acetate, 6,6,10-trimethyl bicyclo-3,1,1-hept-2-ene, and 2-[[1-(3-acetylthio-2-methylpropionyl)pyrrolidine-2-formyl]amino]-3-phenylpropionic acid. The components adopted by the method have strong complexing capability with target substances, high speed of forming complex precipitates, and high removal rate up to 99.9%.
Owner:李海兰
Preparation method of cigarette precursor-aroma phenylpropionic ester and application thereof
InactiveCN106631781AIncrease the amount addedHigh reaction yieldTobacco preparationTobacco treatmentMonomerChemistry
The invention discloses a preparation method of cigarette precursor-aroma phenylpropionic ester. The preparation method includes steps of dissolving phenylpropionic acid and monohydric alcohol in dried methylene dichloride; stirring for 10-30 minutes, and adding 4-dimethylamino pyridine and 1-ethyl-(3-dimethylaminopropyl) carbodiimide hydrochloride; stirring for 4-12h under room temperature; monitoring reaction by TLC and tracking the reaction end point; adding water in an organic phase and washing; separating liquid, and washing the mixture by saturated sodium chloride solution; separating liquid and drying the organic phase by anhydrous Na2SO4; concentrating and acquiring the crude product; performing column chromatography isolation to obtain the cigarette precursor-aroma phenylpropionic ester. In the invention, phenylpropionic geraniol ester, phenylpropionic-beta-ionol ester can significantly improve the addition in cigarette by comparing with geraniol and beta-ionol matrix; the external aroma variety of the cigarette is not influenced; the cigarette precursor-aroma phenylpropionic ester is applied to cigarette as the cigarette fumette, thus the cigarette thrill and offensive odor can be reduced, and the smoke roundness and comfort can be improved.
Owner:HUBEI CHINA TOBACCO IND
Treating agent for removing ethyl alcohol, isopropyl alcohol and octyl alcohol in waste water of amino resin workshop
InactiveCN105016450AStrong complexing abilityFast precipitationWater contaminantsNature of treatment waterOctanolAcetophenone
The invention relates to a treating agent for removing ethyl alcohol, isopropyl alcohol and octyl alcohol in waste water of an amino resin workshop. The treating agent is formed by compounding 1,3,3-trimethyl-2-oxabicyclo[2.2.2]octane, 1,8-dihydroxy-3-methoxy-6-methylanthraquinone, S(-)-2-amino-6-n-propyl-4,5,6,7-tetrahydrobenzothiazole hydrochloride, 4-octylphenol ethoxylate, 3',4'-dihydroxy-2-(methyl amino)acetophenone hydrochloride, 4-acetoxy-3-methoxy-(2-allyl) benzene, acetic acid-4-methoxy-benzyl ester, 6,6,10-trimethylbicyclo-3,1,1-hep-2-ene, 2-[[1-(3-acethythio-2-methypropionyl)pyrrolidine-2-formyl]amino]-3-phenylpropionic acid and the like. The capacity of the treating agent for complexing with a target substance is high, the complex precipitate forming speed is high, and the removing rate can reach 99.9%.
Owner:李海兰
Phenylpropanoic acid derivatives
Owner:TAKEDA PHARMA CO LTD
Synthesis and use of phenylpropionic acid derivatives
InactiveCN106431898AOrganic active ingredientsOrganic chemistry3-phenylpropanoic acidMetabolic stability
The invention discloses a series of phenylpropionic acid derivatives, a preparation method thereof, and a use of the derivatives in pharmacy. The derivatives are compounds represented by formula I. Pharmacodynamic experiments show that the compounds of formula I have good agonist activity to GPR120; an in-vivo metabolism research result shows that the compounds of the formula I have good metabolism stability; and unexpectedly, the compounds have substantially higher agonist activity to the GPR120 after a difluoro substitute group is introduced to a phenyl ring at the carboxyl terminal of the compounds of the formula I. The compounds of the formula I can be used for drugs for preventing diabetes, obesity and other metabolic diseases.
Owner:CHINA PHARM UNIV +1
Microbial transformation method
The invention relates to a method for producing R-(+)-2-hydroxy-3-phenylpropanoic acid by transforming L-phenylalanine by adopting providencia microbes. The method is simple in process and has important industrial application value.
Owner:卓虹超源生物科技(郑州)有限公司
Phenylpropionic acid compound, preparation method therefor and medicinal use thereof
ActiveCN103097367BAntibacterial agentsOrganic active ingredients3-phenylpropanoic acidInhibitory effect
Disclosed is as represented by Formula I a compound or a pharmaceutically acceptable salt thereof. The compound or the pharmaceutically acceptable salt thereof of the present invention can be used as an immunosuppressant. By regulating the transport of leukocytes, and by regulating the cellular transport of lymphocytes, the lymphocytes are gathered in secondary lymphoid tissues, thus improving the integrity of blood vessels to allow for immunosuppression effect, anti-inflammatory activity, and hemostatic effect.
Owner:INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
Preparation of 2-(4-bromophenyl)-2-methylpropanoic acid
InactiveUS20120309973A1Organic compound preparationCarboxylic compound preparation3-phenylpropanoic acidFexofenadine
Selective bromination of 2-methyl-2-phenylpropanoic acid in aqueous medium is described to obtain pure 2-(4-bromophenyl)-2-methylpropanoic acid, which is a useful key intermediate in the process of manufacturing pure fexofenadine.
Owner:DIVI S LAB LTD
A kind of method for efficiently synthesizing β-benzyl butyrolactone with specific configuration
ActiveCN105175365BRaw materials are cheap and easy to getShort stepsOrganic chemistry3-phenylpropanoic acidChemical synthesis
Owner:LIAONING UNIV OF TRADITIONAL CHINESE MEDICINE
Preparation method of ester peptide
InactiveCN103073619AAchieve traceabilityReduce difficultyPeptide preparation methodsBulk chemical production3-phenylpropanoic acidCoupling
The invention relates to the field of chemically synthesized peptides, and particularly relates to a preparation method of an ester peptide. The method employs step-by-step coupling; a carboxyl group of Asp and an amino group of Ser are subjected to a dehydration condensation reaction through a coupling agent to connect into a ring; after removal of a protective group of Thr, 3-(2-amyl)-phenylpropionic acid and an amino terminal of Thr are subjected to a dehydration condensation reaction; and the reaction product is subjected to cracking, precipitation and purification to obtain the ester peptide with a structure shown as a formula I. The method has characteristics of oriented synthesis, better traceability and controllability of analysis on related impurities compared with a fermentation method, and can reduce related impurities to a certain extent in the synthesis phase, so as to reduce the difficulty in purification and improve product yield on the premise of increasing product purity. The method only requires a simple Kaiser detection to monitor the process, and the detection is simple for operation, and has low requirement on equipment.
Owner:HYBIO PHARMA
Novel chemical resolution method for 3-hydroxy-3-phenylpropanoic acid compounds
ActiveCN109232220AAchieve chiral resolutionSimple and fast operationPreparation from carboxylic acid saltsOrganic compound preparation3-phenylpropanoic acidAcetic acid
The invention discloses a novel chemical resolution method for 3-hydroxy-3-phenylpropanoic acid compounds. The method comprises the following steps: (1) 1 kg of 3-hydroxy-3-phenylpropanoic acid (racemate) and 5 L of ethyl acetate are added to a reaction flask, phenethylamine is added, reflux reaction is performed for 1 h, temperature is reduced to 0-10 DEG C for crystallization for 1 h, and a filter cake obtained after filtering is washed with 500 mL of ethyl acetate; (2) the final product in step (1) is added to the reaction flask, and 5 L of 2N hydrochloric acid and 5 L of ethyl acetate areadded; (3) a product is stirred by keeping temperature at 20-30 DEG C for 30 min and left to stand for layering, aqueous phase is extracted with 2 L of ethyl acetate, organic phase is mixed, washed with 5 L of water and 5 L of 10% sodium chloride and condensed under reduced pressure, 3-hydroxy-3-phenylpropanoic acid is obtained, ee is higher than 99%, and yield is higher than 43%. The method can be applied to industrial production and has the advantages of simple operation and low cost.
Owner:SHANGHAI UNIV OF MEDICINE & HEALTH SCI
Cinnamic, Phenylpropiolic and Phenylpropanoic Acid Derivatives Useful as Anti-Tumor Agents
Cinnamic and phenylpropiolic acid derivatives of formula (I) having antitumour and chemo sensitizing activity are described. Also described are pharmaceutical compositions containing the above-mentioned compounds, for the treatment of tumours.
Owner:SIGMA TAU IND FARMACEUTICHE RIUNITE SPA
Improved preparation method of Nagelinei
Owner:INST OF PHARMACOLOGY & TOXICOLOGY ACAD OF MILITARY MEDICAL SCI P L A
Optical isomer of phenylpropionic acid and its medicinal use
Optical isomers of phenylpropionic acid drugs are a mixture having R-type optical isomer and S-type optical isomer at a ratio of 10:1-1:10 by weight, wherein the ratio of 1:1 is excluded. A use of the optical isomers includes that the R-type optical isomer is used for manufacturing anti-inflammatory and analgesic drugs and the mixture having the R-type optical isomer and the S-type optical isomer at a ratio of 10:1-1:10 by weight, wherein the ratio of 1:1 is excluded, is used for manufacturing anti-inflammatory and analgesic drugs. The therapeutic indexes of anti-inflammatory and analgesic drugs of the present optical isomers are all higher than those of the S-type optical isomers and the racemate.
Owner:HEFEI JINKE BIOPHARML TECH
Cabazitaxel crystal and preparation method thereof
A crystal of cabazitaxel, 7,10-dimethoxydocetaxel or (2R,3S)-3-tert-butoxycarbonylamino-2-hydroxy-3-phenylpropanoic acid 4-acetoxy -Ansolvate of 2α-benzoyloxy-5β,20-epoxy-1-hydroxy-7β,10β-dimethoxy-9-oxo-11-taxene-13α-yl ester, A crystalline form without water of crystallization characterized by a PXRD pattern showing the positions Characteristic peaks at 26.1, 27.3, 29.3, 31.9, 32.5 and 35.8° 2Θ. The preparation method is also disclosed; the present invention is prepared under reduced pressure and room temperature, and has high yield and good purity.
Owner:SHANGHAI JINHE BIO TECH
Cinnamic, phenylpropiolic and phenylpropanoic acid derivatives useful as anti-tumor agents
Cinnamic and phenylpropiolic acid derivatives of formula (I) having antitumour and chemo sensitizing activity are described. Also described are pharmaceutical compositions containing the above-mentioned compounds, for the treatment of tumours.
Owner:SIGMA TAU IND FARMACEUTICHE RIUNITE SPA
A method of microbial transformation
ActiveCN105543291BMicroorganism based processesFermentation3-phenylpropanoic acidMicrobial transformation
The invention relates to a method for producing R-(+)-2-hydroxy-3-phenylpropanoic acid by transforming L-phenylalanine by adopting providencia microbes. The method is simple in process and has important industrial application value.
Owner:卓虹超源生物科技(郑州)有限公司
A method for electrochemically synthesizing optically active 2-phenylpropionic acid
InactiveCN103789791BEfficient use ofEfficient synthesisElectrolysis componentsElectrolytic organic productionN dimethylformamideCobalt
The invention discloses an electrochemical synthesis method of 2-phenylpropionic acid with optical activity. The method is characterized by comprising the following steps: mixing 1-chlorine-1-phenylethane with N, N-dimethylformamide or acetonitrile and tetraalkylammonium salt to form an electrolyte solution, by taking a chiral schiff base cobalt complex as a catalyst, carrying out electric carboxylation reaction in the presence of normal pressure saturated carbon dioxide by using constant current or constant potential, carrying out rotary evaporation and extraction on the electrolytic reaction liquid to obtain the 2-phenylpropionic acid with the optical activity. Compared with the prior art, the method disclosed by the invention is simple in process and convenient in operation and has the advantages that the greenhouse-effect gas carbon dioxide can be effectively utilized and the atmospheric pollution is reduced; in the meantime, the conversion of aromatic chlorides and the effective synthesis of chiral matters are realized; the raw materials are low in price and easily available, so that the method is low in cost; a new way is created for the research on the green synthesis of organic matters such as aromatic carboxylic acid derivatives; the method particularly shows an excellent application prospect in the fields of agriculture and drug synthesis and is a process route with great industrial synthesis value.
Owner:EAST CHINA NORMAL UNIV
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