1 results about "Albumin concentrations" patented technology

The application discloses an organic small molecule which can be activated by alkaline phosphatase and visible light, and a preparation method and application thereof. The structural formula of the organic small molecule is shown as formula I. The organic small molecule and cis-trans isomers thereof exist in a stable cis or trans configuration under dark conditions and have no cytotoxicity. Under visible light irradiation, the organic small molecule undergoes cis-trans isomerization, and the isomerization efficiency is regulated by the concentration of serum albumin in the environment. Based on this, the good biocompatibility of visible light and the wide existence of albumin in vivo can be used as a double regulation means, so that the organic small molecule has no toxic side effects under high serum albumin physiological conditions. In a tumor cell environment, through visible light irradiation and albumin concentration removal, the organic small molecule is in a trans configuration, and through alkaline phosphatase reaction, the organic small molecule has a high tumor cell killing ability, achieves time and space control of drug activity, and has application prospects in on-demand precise treatment of tumors.