121 results about "Amniotic liquid" patented technology

The present invention relates to an incubation system for liquid-based incubation of prematurely born infants, comprising: —an inner chamber forming an amniotic basin comprising amniotic fluid, said basin being configured for holding said infant and being made from a flexible material configured for expanding said inner chamber volume in correspondence with the growth of said infant; —an outer chamber enclosing said inner chamber and comprising a temperature regulation fluid, —a fetal connection port, arranged for connecting with the umbilical cord of said infant, said umbilical cord providing a port in said inner chamber to said infant for providing dialyzation and nutrition compounds to said infant via said umbilical cord; —a fetal control unit, connected to said fetal connection port for control of said dialyzation and control of said provided nutrition by monitoring and controlling one or more of a pressure, flow and temperature thereof; an amniotic fluid circulation unit, arranged for connecting with an inlet / outlet port of said inner chamber and comprising a pump for circulating said amniotic fluid from said inner chamber and through a purification system located outside said inner chamber; and —a temperature regulation fluid control unit, arranged for connecting with an inlet / outlet port of said outer chamber and comprising a pump for circulating said temperature regulation fluid from said outer chamber and through a heat exchanger system located outside said inner chamber.

A multi-part processed human amniotic composition configured to treat Peyronie's disease in a subject in need thereof by intracorporeal injection of the composition into the corpus cavernosum of the subject to reduce plaque size associated with Peyronie's disease. The multi-part processed human amniotic composition includes a micronized human amnion composition; and an aqueous human amniotic fluid filtrate configured to reconstitute and suspend the micronized human amnion composition therein. In certain aspects, the multi-part processed human amniotic compositions are not processed with exogenous enzymes during production thereof and do not include exogenous enzymes, such as collagenase, added thereto.

The present invention discloses a method for synchronously extracting and detecting 59 endocrine disruptors in amniotic fluid, belonging to the technical field of substance detection. The method includes the following steps: S1, adding β-glucuronidase to the amniotic fluid sample and incubating; S2, adding a stable isotope-labeled internal standard to the amniotic fluid sample to be detected in step S1; S3, adding the amniotic fluid sample to be detected in step S2 to an activated HLB extraction column to remove impurities and extract the target analyte; S4, eluting the extraction column to obtain an eluate, blowing it to near dryness, and adding a reconstitution solvent to obtain a sample to be detected; S5, using a liquid chromatography-mass spectrometry instrument to detect the sample to be detected obtained in step S4 to complete the detection and analysis of endocrine disruptors. The detection process is carried out simultaneously in positive ion mode and negative ion mode. This method realizes the synchronous extraction, detection and analysis of at least 59 typical environmental endocrine disruptors in amniotic fluid, which is simple and convenient, and solves the problems of large sample consumption and long time consumption.

The utility model belongs to the technical field of membrane rupturing devices, and particularly relates to an amniotic membrane rupturing device for gynaecology and obstetrics, which comprises a handle, one end of the handle is fixedly connected with a membrane rupturing hook, and the membrane rupturing hook is arranged towards the other end of the handle; the front face and the back face of the handle are each provided with a liquid guide groove formed in the length direction of the handle, the handle is provided with penetrating holes corresponding to the liquid guide grooves, and the penetrating holes are all formed in the ends, away from the membrane breaking hooks, of the liquid guide grooves. A handheld part is arranged at one end, far away from the membrane rupture hook, of the handle, and an annular groove is further formed in the handle and is formed between the handheld part and the liquid guide groove; the utility model provides the amniotic membrane rupture device for the obstetrics and gynecology department, which can be used for guiding amniotic fluid.

The invention discloses an amniotic fluid drainage device for an operating room. The amniotic fluid drainage device comprises a drainage box and a fixing cylinder. A drainage tube is arranged at the upper end of the drainage box and movably connected with the fixing cylinder; the interior of the fixing cylinder is hollow, the upper end is provided with a fixing ring, two sides are symmetrically provided with depth sliding grooves which are slidably connected with fixing rods, a plurality of fixing grooves are arranged along one side of each depth sliding groove in an array mode, the other side is provided with scales, and two sides of the bottom are symmetrically provided with fixing pieces. The middle of the fixing rod is provided with a limiting ring rotationally connected with the needle handle; the front end of the needle handle is provided with the needle body, and the rear end is provided with the hard tube slidably connected with the fixing ring. The hard tube penetrates through the fixed cylinder and is provided with a drainage tube which is movably connected with the drainage box; through sliding fit of the fixing rod and the depth sliding groove, the height of the fixing rod in the fixing cylinder can be visually adjusted along the scales, and precise control over the insertion depth of the puncture needle is achieved in combination with rotary connection of the limiting ring and the needle handle.

The invention relates to a new application of early-stage chick embryo amniotic fluid, which is characterized in that the early-stage chick embryo amniotic fluid is found to be capable of effectively dispelling the effects of alcohol, removing the content of ethanol in serum and increasing the levels of liver acetaldehyde dehydrogenase and ethanol dehydrogenase by evaluating the effect of dispelling the effects of alcohol of the early-stage chick embryo amniotic fluid, and also has the effects of protecting the gastric mucosa function and the like.

The invention relates to the technical field of medicines, in particular to application of sialic acid in preparation of a medicine for promoting stem cell migration, the administration concentration of the sialic acid is 0.625 mM to 5mM, the sialic acid (SA) has the influence on proliferation and migration of amniotic fluid mesenchymal stem cells (AFMSCs), the sialic acid with the concentration of 0.625 mM, 1.25 mM, 2.5 mM and 5mM is used for experiments, and results show that the sialic acid with the concentration of 0.625 mM, 1.25 mM, 2.5 mM and 5mM has the influence on the proliferation and migration of the AFMSCs. The migration of the amniotic fluid mesenchymal stem cells is promoted, and the migration rate of the AFMSCs is 100% due to the SA with the concentration of 1.25 mM, 2.5 mM and 5 mM in 48 hours.

The utility model discloses a degradable amniotic fluid absorption pad which comprises an outer groove pad and an inner water absorption pad, the outer groove pad is a degradable waterproof groove pad, the inner water absorption pad is a degradable water absorption pad, a waterproof coating is arranged on the outer wall of the outer groove pad, the bottom of the inner water absorption pad is bonded to the groove bottom of the outer groove pad through a bonding layer, a plurality of water inlet grooves are formed in the inner water absorption pad, and the water inlet grooves are communicated with the water inlet grooves. Water absorption holes are formed in the side wall of the water inlet groove, the outer groove pad is made of poly (butylene succinate), the inner water absorption pad is made of polylactic acid non-woven fabric, poly (butylene succinate) and poly (butylene succinate) are both degradable materials, and the inner water absorption pad is torn off to be separated from the outer groove pad after use, so that the thickness can be reduced, and the degradation speed can be increased; during use, amniotic fluid of a pregnant woman is absorbed through the inner water absorption pad, meanwhile, the amniotic fluid is prevented from seeping out of the outer groove pad, the contact area of the inner water absorption pad and the amniotic fluid can be increased through the arrangement of the water inlet groove and the water absorption holes, and the effects of shunting, delaying flowing, accelerating amniotic fluid absorption and rapidly absorbing the amniotic fluid are achieved.

The invention relates to the technical field of medical tools, in particular to an artificial membrane rupturing structure which comprises a barrel and a suction cup mounted at the top end of the barrel and further comprises a guide seat, a membrane rupturing device, a membrane rupturing device and a membrane rupturing device, the guide seat is mounted in the barrel, and a through hole is formed in the guide seat; the adsorption mechanism is installed in the cylinder body and connected with the guide seat, and the adsorption mechanism enables the suction cup to be adsorbed to the surface of the amniotic membrane; the artificial membrane rupturing structure is different from the prior art, in the using process of medical staff, the amniotic membrane can be clamped and fixed only by attaching the suction cup to the amniotic membrane and then pulling the hollow push rod, then puncturing is automatically conducted, the flow speed after membrane rupturing is stable, the membrane rupturing can be easily completed even though the medical staff with less experience, and operation is easy; the amniotic fluid after rupture of the membrane automatically flows to the outside through the drainage tube from the inside of the cylinder, and the amniotic fluid is not in contact with the uterus of the pregnant woman, so that the probability of infection in the uterus of the pregnant woman is greatly reduced, and the turbidity of the amniotic fluid flowing out can be directly observed.

The utility model discloses a visualized amniotic fluid puncture outfit relates to medical instrument technical field, including superfine endoscope and puncture component, the puncture component includes T-type drainage tube, the both sides of T-type drainage tube are provided with drainage connection port, the drainage connection port is controlled by flow valve, and the drainage connection port is connected with the flow valve. A puncture needle tube is arranged at the bottom of the T-shaped drainage tube, the top of the T-shaped drainage tube is connected with a superfine endoscope through a connecting fastener, a superfine endoscope lens is arranged at the bottom of the superfine endoscope, and the superfine endoscope lens is inserted into the puncture needle tube. According to the amniotic fluid puncture needle, a doctor can directly perform puncture operation, the risk of accidentally injuring tissues of a fetus and a maternal body is remarkably reduced, the position of the needle head and the puncture depth can be more accurately judged, and the efficiency of amniotic fluid puncture is improved.

The utility model discloses a blood separator based on puerpera bleeding detection. The blood separator comprises a shell, the upper part of the shell is provided with circular groove bodies which are symmetrically arranged; a rotary drum is rotationally connected into the tank body; a hollow shaft is fixedly connected to the bottom center of the drum; a separation cylinder is arranged in each rotating cylinder; limiting blocks which are symmetrically arranged are fixedly connected to the outer side of the separating cylinder; limiting grooves are formed in the positions, corresponding to the limiting blocks, of the side wall of the rotary drum. After a medical worker uses the separating cylinder to receive amniotic fluid and blood mixed liquid flowing out of a puerpera, the amniotic fluid and blood mixed liquid is placed in the rotating cylinder, the motor is used for driving the rotating cylinder to rotate, then the mixed liquid is centrifuged in the rotating cylinder under the cooperation of the rotating cylinder, the separating cylinder and the curved plate, and the sliding rod can be operated after standing for a little time; according to the scheme, blood is discharged into the container, then medical staff can know the condition of the puerpera by observing the blood in real time, and guarantee is provided for life safety of the puerpera.

Provided is a product that enables easy monitoring of early rupture of membranes and relates to a wearing article provided with a test strip using immunochromatography, wherein the test strip is designed to detect amniotic fluid-derived insulin-like growth factor binding protein 1 in vaginal secretion, and wherein, when the test strip detects 0.3-25 mg / L of insulin-like growth factor binding protein 1, the result is considered positive.

The described invention provides compositions and methods for wound healing in a subject. The methods include administering a therapeutic amount of a pharmaceutical composition comprising extracellular vesicles from amniotic fluid and a pharmaceutically acceptable carrier.

A composition for treating a patient with a tissue disease or malformity has a composition containing amniotic fluid. The amniotic fluid has a quantity of gender specific amniotic fluid based on a gender of a fetal source. A method of treating a patient with a tissue disease or malformity comprises the steps of: identifying the tissue region to be treated and selecting a location to apply either topically or by injection or inhalation a composition containing amniotic fluid; selecting the composition containing amniotic fluid wherein the amniotic fluid has a quantity of gender specific amniotic fluid based on a gender of a fetal source allowing more specific targeted growth factors to be used for specific disease processes; and applying or injecting the composition at or into the selected location.

This invention proposes an intelligent labor management method and system that integrates LP (labor delivery) detection and multi-parameter monitoring. It belongs to the interdisciplinary fields of smart obstetrics, multimodal physiological monitoring, and human factors engineering. The method includes: dividing the labor process of primiparous women into multimodal monitoring areas, generating core obstetric parameter monitoring areas, and collecting psychological stress monitoring data via millimeter-wave radar and continuously monitoring the fetal biochemical environment via amniotic fluid biochemical probes; deploying the LP labor detection system, non-contact psychological sensors, and amniotic fluid biochemical probes based on these areas to construct an intelligent monitoring layout network; by integrating LP labor detection and multi-parameter monitoring, the overall efficiency of labor management is significantly improved: it achieves accurate monitoring of traditional parameters such as cervical dilation and fetal heart rate, and expands the holistic perception of key dimensions such as maternal psychological stress and amniotic fluid biochemical environment, greatly improving the completeness and real-time performance of labor monitoring.

Provided is a composition including stem cell is derived from amniotic fluid of an artiodactyl animal. Also provided relates to uses of the composition for skin rejuvenation, skin treatment. promoting hair growth, and preventing hair loss, including administering an effective amount of the composition to the subject in need thereof.

The invention relates to an in-utero ventriculoamniotic shunting device that includes a composite shunt tube composed of polymer material, e.g., silicone-based material, and metallic wire, having a bend or curve formed in the length of the shunt tube, with one or more anchors composed of super-elastic wire or mesh, e.g., shape memory alloy wire or mesh structures, attached to the shunt tube, and a one-way passive valve composed of a thin polymer membrane. The anchors are effective to prevent migration and dislodgement of the shunting device following its deployment, and the valve is effective to prevent the backflow of amniotic fluid.

The invention relates to the field of hyperbaric oxygen therapy, in particular to an effect on body rehabilitation therapy in a gravity-free diving state in a closed high-pressure liquid environment. The hyperbaric oxygen zero-gravity rehabilitation treatment cabin comprehensively adopts the most advanced technology to restore the optimal environment state of hyperbaric oxygen rehabilitation treatment. A main cabin of the equipment is of a totally-closed structure, and the main cabin is filled with rehabilitation liquid containing different solutes. The main cabin is provided with a circulating breathing system, a constant temperature system and an emergency decompression system, and a relay liquid storage tank and a pressurization system are arranged outside the main cabin. After the main chamber is sealed and pressurized, the circulating breathing system can supply high-pressure oxygen air, and continuous supply and monitoring of high-pressure oxygen breathing under different pressures are achieved. Rehabilitation personnel in the main cabin gradually enter a weightlessness suspension state. The hyperbaric oxygen zero-gravity rehabilitation treatment cabin simulates and realizes an amniotic fluid-like environment. The conditions of temperature, pressure, gravity, aerobic regeneration of body tissues and the like of a fetus in an amniotic fluid state are represented to a certain extent.

The invention discloses an amniotic fluid and bleeding integrated measuring bag for delivery, and belongs to the technical field of medical auxiliary instruments. Comprising a U-shaped measuring bag body, the top of the measuring bag body is fixedly communicated with a liquid inlet pipe, two partition plates are fixedly connected to the interior of the measuring bag body, a containing cavity used for containing amniotic fluid or blood is formed between the partition plates and the side wall of the measuring bag body, and two scale marks are formed in the measuring bag body. Scale marks are formed in the two partition plates and correspond to the containing cavities in a one-to-one mode, liquid inlets are formed in the two partition plates, a flow guide mechanism is arranged between the two partition plates, and through cooperation of the partition plates, the liquid inlets and the flow guide mechanism, during delivery of a puerpera, amniotic fluid and blood can flow into the different containing cavities respectively by adjusting the inclination angle of a liquid dripping plate; therefore, amniotic fluid and blood can be collected and measured at the same time, the workload of medical staff can be reduced, and the measurement accuracy can be improved.

The utility model is applicable to the field of medical instruments, and provides a safe membrane rupture device for obstetrics, which comprises a barrel, a plurality of vent holes are arranged at the upper end of the barrel, a threaded rod is in threaded connection with the upper end of the barrel, an I-shaped ring is fixedly connected with the lower end of the threaded rod, and the I-shaped ring is rotatably connected with a connecting frame. The lower end of the connecting frame is fixedly connected with an abutting plate. A lower bottom plate is slidably connected to the inner wall of the barrel, a membrane rupture needle is fixedly connected to the lower end of the lower bottom plate and used for puncturing amniotic fluid, a middle column is fixedly connected to the upper end of the lower bottom plate, an upper bottom plate is fixedly connected to the upper end of the middle column, and a resistance assembly is arranged on the upper bottom plate in a matched mode. A plurality of symmetrical first vent grooves are formed in the lower bottom plate, a plurality of symmetrical second vent grooves are formed in the middle column, and a plurality of symmetrical third vent grooves are formed in the upper bottom plate. The amniotic fluid puncturing device has the advantages that the amniotic fluid puncturing depth is controllable, and the amniotic fluid is effectively sucked away.

The invention provides a disposable measurable birth process pad. The disposable measurable birth process pad comprises a drawsheet body, a first drainage piece is arranged on the drawsheet body, a second drainage piece is fixedly connected to the first drainage piece, and a barrier strip and a shaping strip are fixedly connected to the first drainage piece. Through the arrangement of the barrier strip, part of liquid flowing to the concave area is prevented from making contact with the buttocks of a puerpera, through the arrangement of the thin pipe and the liquid inlet pipe, the liquid collected in the concave area can be discharged into the collecting bag in time, and through the cooperation of the thin pipe and the liquid inlet pipe, the problem that in the prior art, the buttocks of the puerpera cannot be collected is solved. In the prior art, due to the fact that a parturition pad in an area in contact with the buttocks is slightly sunken, part of amniotic fluid or blood flows to the area to be in contact with the buttocks, and in the prior art, the amniotic fluid or the blood in the area is either adsorbed away through a water absorption layer to reduce discomfort of a puerpera, or is not treated, so that the parturition pad can be used for absorbing the amniotic fluid or the blood in the area to be in contact with the buttocks. Obviously, the amniotic fluid or the bloody water cannot be accurately collected in any mode.

The invention relates to an obstetrical amniotic fluid drainage device which comprises an insertion tube body and a drainage piece connected into the tube body, the drainage piece comprises a drainage tube body connected with the upper end of the insertion tube body, and the drainage tube body is used for drainage of amniotic fluid; the insertion tube body is connected with an air bag part, the air bag part comprises an annular air inflation bag connected to the upper end of the insertion tube body, and the annular air bag is used for blocking the vagina after being inflated so that amniotic fluid can fully enter the drainage tube body. The technical scheme has the advantages that after the annular air bag is inflated, the effect of blocking the vagina can be achieved, in this way, it is ensured that amniotic fluid can fully enter the drainage tube body, and therefore effective amniotic fluid drainage is achieved. The problems that in the prior art, amniotic fluid cannot fully and stably enter a drainage tube, so that the drainage effect is poor, and clinical actual requirements cannot be met are solved.

The invention belongs to the technical field of medical instruments, and particularly relates to an amniotic fluid puncture positioning device used in an antenatal diagnosis center, which comprises a support mechanism, a self-adaptive contour sensing mechanism, a self-adaptive angle adjusting mechanism and a puncture needle inserting guide mechanism, the puncture position is determined; when the self-adaptive angle adjusting mechanism works, the puncture angle is always perpendicular to the uterine amniotic fluid position of a puerpera; the puncture needle inserting guide mechanism has a first state when the puncture needle cannot be inserted due to locking and a second state when the puncture needle is conveniently inserted after locking is released, and when the self-adaptive angle adjusting mechanism works to enable the puncture angle to be perpendicular to the uterus of the puerpera, the puncture needle inserting guide mechanism is automatically driven to be switched from the first state to the second state; the problems that in the positioning process, electronic equipment is excessively relied on, self-adaptive positioning cannot be carried out according to the body posture of a puerpera, and normal operation of a puncture operation is affected are solved.

An apparatus for filtering amniotic fluid containing particulate matter and amniotic cells is disclosed, comprising a filter for filtering the particulate matter from the amniotic fluid, a chamber enclosing the filter, wherein the chamber comprises a fluid inlet and a fluid outlet, and an inlet connector arranged to form a sealing connection between the fluid inlet and an amniotic fluid sample source, wherein, in use, the amniotic fluid pass the filter when flowing from the fluid inlet to the fluid outlet, whereby particulate matter is deposited on the filter and the amniotic fluid flows through the fluid outlet containing amniotic cells.

Methods of reducing T cell activation including co-culturing with T cells, term amniotic fluid mesenchymal stem cells (TAF-MSCs) isolated from term human amniotic fluid. Other aspects relate to methods of inhibiting macrophage polarization toward the M1 pro-inflammatory phenotype including co-culturing with macrophages TAF-MSCs isolated from term human amniotic fluid. Other aspects relate to methods of inhibiting cytokine secretion from activated Peripheral Blood Mononuclear Cell (PBMC) including co-culturing with the PBMC tissue-typed TAF-MSCs isolated from human amniotic fluid. Other aspects relate to methods of differentiating TAF-MSC including: obtaining TAF-MSC cells from term amniotic fluid, plating the TAF-MSC cells in limiting dilution to obtain expanded colonies from single cells, and transferring the cells to a differentiation media that contains one or more factor to differentiate the TAF-MSC cells.

The invention discloses application of CTSB as a congenital maxillofacial deformity diagnostic marker in preparation of a diagnostic reagent, and relates to the technical field of biomedicine.Early auxiliary diagnosis of congenital maxillofacial deformity is achieved by detecting the mRNA expression level or protein expression level of CTSB in a biological sample, and when the expression level is higher than that of a healthy control by two times or above, the CTSB can be used as the diagnostic marker for the congenital maxillofacial deformity. And the congenital maxillofacial deformity risk is prompted. The biological sample comprises blood, saliva, amniotic fluid or a palate embryo mesenchymal cell tissue sample. Early auxiliary diagnosis of congenital maxillofacial deformity can be realized by detecting the expression level of CTSB in a biological sample, and targeted therapeutic drugs can be developed by inhibiting the activity or expression of CTSB. The problems that in the prior art, congenital maxillofacial deformity diagnosis lags behind, and treatment lacks specificity are solved, and a new theoretical basis and a new technical means are provided for prevention and treatment of congenital maxillofacial deformity.

Provided is a method for treating disorders or conditions related to erectile dysfunction. The method includes administering to a subject in need thereof a therapeutically effective amount of mesenchymal stem cells or secretome thereof, wherein the mesenchymal stem cells or secretome are derived from human amniotic fluid.

The invention relates to the technical field of ruptured amniotic fluid storage, and provides a ruptured amniotic fluid storage device for gynaecology and obstetrics medical treatment, the ruptured amniotic fluid storage device comprises a mobile auxiliary mechanism, an amniotic fluid ruptured amniotic fluid collection mechanism and a base, the mobile auxiliary mechanism is mounted on the base, the amniotic fluid ruptured amniotic fluid collection mechanism is mounted on the top of the mobile auxiliary mechanism, and the mobile auxiliary mechanism is mounted on the base. The moving auxiliary mechanism is composed of moving operation assemblies arranged at the bottom and one side of the base and a lifting assembly arranged at the top of the moving operation assemblies, through the arrangement of the moving auxiliary mechanism, the lifting assembly and other structures, the amniotic fluid ruptured membrane collector can move flexibly, the height is adjustable, the use angle can be adjusted according to needs, and the use efficiency is improved. According to the technical scheme, the applicability and operation convenience of the equipment are greatly improved, meanwhile, through cooperation of the pushing assembly and the membrane breaking assembly, stable stretching and membrane breaking operation of the main cylinder are achieved, the membrane breaking safety and accuracy are improved, and through the technical scheme, the problems that in the prior art, safety is insufficient, and precision is insufficient are solved.

The invention discloses a fetal giant child prediction method and system based on machine learning in the field of medical health of artificial intelligence, and the method comprises the following steps: S1, data collection: collecting ultrasonic examination data and clinical feature data of a late pregnancy (greater than or equal to 37 weeks) single-fetal pregnant woman, and constructing an original data set; the ultrasonic examination data comprises fetal biparietal diameter (BPD), femur length (FL), abdominal circumference (AC), head circumference (HC), amniotic fluid index (AFI) and ultrasonic weight estimation, and the clinical characteristic data comprises pregnant woman pre-pregnancy body weight index (BMI), pregnancy body weight increment (GWG), examination week of pregnancy (GA) and fetal gender. The giant child prediction method based on machine learning provided by the invention has significant clinical application value and technical advantages, can effectively improve the prediction ability of fetal giant child, promotes the intelligent and precise development of the obstetrical field, and has important practical significance for improving the health level of mothers and infants.