72 results about "Amniotic liquid" patented technology

The utility model belongs to the technical field of membrane rupturing devices, and particularly relates to an amniotic membrane rupturing device for gynaecology and obstetrics, which comprises a handle, one end of the handle is fixedly connected with a membrane rupturing hook, and the membrane rupturing hook is arranged towards the other end of the handle; the front face and the back face of the handle are each provided with a liquid guide groove formed in the length direction of the handle, the handle is provided with penetrating holes corresponding to the liquid guide grooves, and the penetrating holes are all formed in the ends, away from the membrane breaking hooks, of the liquid guide grooves. A handheld part is arranged at one end, far away from the membrane rupture hook, of the handle, and an annular groove is further formed in the handle and is formed between the handheld part and the liquid guide groove; the utility model provides the amniotic membrane rupture device for the obstetrics and gynecology department, which can be used for guiding amniotic fluid.

The invention discloses an amniotic fluid drainage device for an operating room. The amniotic fluid drainage device comprises a drainage box and a fixing cylinder. A drainage tube is arranged at the upper end of the drainage box and movably connected with the fixing cylinder; the interior of the fixing cylinder is hollow, the upper end is provided with a fixing ring, two sides are symmetrically provided with depth sliding grooves which are slidably connected with fixing rods, a plurality of fixing grooves are arranged along one side of each depth sliding groove in an array mode, the other side is provided with scales, and two sides of the bottom are symmetrically provided with fixing pieces. The middle of the fixing rod is provided with a limiting ring rotationally connected with the needle handle; the front end of the needle handle is provided with the needle body, and the rear end is provided with the hard tube slidably connected with the fixing ring. The hard tube penetrates through the fixed cylinder and is provided with a drainage tube which is movably connected with the drainage box; through sliding fit of the fixing rod and the depth sliding groove, the height of the fixing rod in the fixing cylinder can be visually adjusted along the scales, and precise control over the insertion depth of the puncture needle is achieved in combination with rotary connection of the limiting ring and the needle handle.

The invention relates to the technical field of medical tools, in particular to an artificial membrane rupturing structure which comprises a barrel and a suction cup mounted at the top end of the barrel and further comprises a guide seat, a membrane rupturing device, a membrane rupturing device and a membrane rupturing device, the guide seat is mounted in the barrel, and a through hole is formed in the guide seat; the adsorption mechanism is installed in the cylinder body and connected with the guide seat, and the adsorption mechanism enables the suction cup to be adsorbed to the surface of the amniotic membrane; the artificial membrane rupturing structure is different from the prior art, in the using process of medical staff, the amniotic membrane can be clamped and fixed only by attaching the suction cup to the amniotic membrane and then pulling the hollow push rod, then puncturing is automatically conducted, the flow speed after membrane rupturing is stable, the membrane rupturing can be easily completed even though the medical staff with less experience, and operation is easy; the amniotic fluid after rupture of the membrane automatically flows to the outside through the drainage tube from the inside of the cylinder, and the amniotic fluid is not in contact with the uterus of the pregnant woman, so that the probability of infection in the uterus of the pregnant woman is greatly reduced, and the turbidity of the amniotic fluid flowing out can be directly observed.

The utility model discloses a visualized amniotic fluid puncture outfit relates to medical instrument technical field, including superfine endoscope and puncture component, the puncture component includes T-type drainage tube, the both sides of T-type drainage tube are provided with drainage connection port, the drainage connection port is controlled by flow valve, and the drainage connection port is connected with the flow valve. A puncture needle tube is arranged at the bottom of the T-shaped drainage tube, the top of the T-shaped drainage tube is connected with a superfine endoscope through a connecting fastener, a superfine endoscope lens is arranged at the bottom of the superfine endoscope, and the superfine endoscope lens is inserted into the puncture needle tube. According to the amniotic fluid puncture needle, a doctor can directly perform puncture operation, the risk of accidentally injuring tissues of a fetus and a maternal body is remarkably reduced, the position of the needle head and the puncture depth can be more accurately judged, and the efficiency of amniotic fluid puncture is improved.

Provided is a product that enables easy monitoring of early rupture of membranes and relates to a wearing article provided with a test strip using immunochromatography, wherein the test strip is designed to detect amniotic fluid-derived insulin-like growth factor binding protein 1 in vaginal secretion, and wherein, when the test strip detects 0.3-25 mg / L of insulin-like growth factor binding protein 1, the result is considered positive.

The described invention provides compositions and methods for wound healing in a subject. The methods include administering a therapeutic amount of a pharmaceutical composition comprising extracellular vesicles from amniotic fluid and a pharmaceutically acceptable carrier.

A composition for treating a patient with a tissue disease or malformity has a composition containing amniotic fluid. The amniotic fluid has a quantity of gender specific amniotic fluid based on a gender of a fetal source. A method of treating a patient with a tissue disease or malformity comprises the steps of: identifying the tissue region to be treated and selecting a location to apply either topically or by injection or inhalation a composition containing amniotic fluid; selecting the composition containing amniotic fluid wherein the amniotic fluid has a quantity of gender specific amniotic fluid based on a gender of a fetal source allowing more specific targeted growth factors to be used for specific disease processes; and applying or injecting the composition at or into the selected location.

This invention proposes an intelligent labor management method and system that integrates LP (labor delivery) detection and multi-parameter monitoring. It belongs to the interdisciplinary fields of smart obstetrics, multimodal physiological monitoring, and human factors engineering. The method includes: dividing the labor process of primiparous women into multimodal monitoring areas, generating core obstetric parameter monitoring areas, and collecting psychological stress monitoring data via millimeter-wave radar and continuously monitoring the fetal biochemical environment via amniotic fluid biochemical probes; deploying the LP labor detection system, non-contact psychological sensors, and amniotic fluid biochemical probes based on these areas to construct an intelligent monitoring layout network; by integrating LP labor detection and multi-parameter monitoring, the overall efficiency of labor management is significantly improved: it achieves accurate monitoring of traditional parameters such as cervical dilation and fetal heart rate, and expands the holistic perception of key dimensions such as maternal psychological stress and amniotic fluid biochemical environment, greatly improving the completeness and real-time performance of labor monitoring.

Provided is a composition including stem cell is derived from amniotic fluid of an artiodactyl animal. Also provided relates to uses of the composition for skin rejuvenation, skin treatment. promoting hair growth, and preventing hair loss, including administering an effective amount of the composition to the subject in need thereof.

The invention relates to an in-utero ventriculoamniotic shunting device that includes a composite shunt tube composed of polymer material, e.g., silicone-based material, and metallic wire, having a bend or curve formed in the length of the shunt tube, with one or more anchors composed of super-elastic wire or mesh, e.g., shape memory alloy wire or mesh structures, attached to the shunt tube, and a one-way passive valve composed of a thin polymer membrane. The anchors are effective to prevent migration and dislodgement of the shunting device following its deployment, and the valve is effective to prevent the backflow of amniotic fluid.

The invention discloses an amniotic fluid and bleeding integrated measuring bag for delivery, and belongs to the technical field of medical auxiliary instruments. Comprising a U-shaped measuring bag body, the top of the measuring bag body is fixedly communicated with a liquid inlet pipe, two partition plates are fixedly connected to the interior of the measuring bag body, a containing cavity used for containing amniotic fluid or blood is formed between the partition plates and the side wall of the measuring bag body, and two scale marks are formed in the measuring bag body. Scale marks are formed in the two partition plates and correspond to the containing cavities in a one-to-one mode, liquid inlets are formed in the two partition plates, a flow guide mechanism is arranged between the two partition plates, and through cooperation of the partition plates, the liquid inlets and the flow guide mechanism, during delivery of a puerpera, amniotic fluid and blood can flow into the different containing cavities respectively by adjusting the inclination angle of a liquid dripping plate; therefore, amniotic fluid and blood can be collected and measured at the same time, the workload of medical staff can be reduced, and the measurement accuracy can be improved.

The utility model is applicable to the field of medical instruments, and provides a safe membrane rupture device for obstetrics, which comprises a barrel, a plurality of vent holes are arranged at the upper end of the barrel, a threaded rod is in threaded connection with the upper end of the barrel, an I-shaped ring is fixedly connected with the lower end of the threaded rod, and the I-shaped ring is rotatably connected with a connecting frame. The lower end of the connecting frame is fixedly connected with an abutting plate. A lower bottom plate is slidably connected to the inner wall of the barrel, a membrane rupture needle is fixedly connected to the lower end of the lower bottom plate and used for puncturing amniotic fluid, a middle column is fixedly connected to the upper end of the lower bottom plate, an upper bottom plate is fixedly connected to the upper end of the middle column, and a resistance assembly is arranged on the upper bottom plate in a matched mode. A plurality of symmetrical first vent grooves are formed in the lower bottom plate, a plurality of symmetrical second vent grooves are formed in the middle column, and a plurality of symmetrical third vent grooves are formed in the upper bottom plate. The amniotic fluid puncturing device has the advantages that the amniotic fluid puncturing depth is controllable, and the amniotic fluid is effectively sucked away.

The invention provides a disposable measurable birth process pad. The disposable measurable birth process pad comprises a drawsheet body, a first drainage piece is arranged on the drawsheet body, a second drainage piece is fixedly connected to the first drainage piece, and a barrier strip and a shaping strip are fixedly connected to the first drainage piece. Through the arrangement of the barrier strip, part of liquid flowing to the concave area is prevented from making contact with the buttocks of a puerpera, through the arrangement of the thin pipe and the liquid inlet pipe, the liquid collected in the concave area can be discharged into the collecting bag in time, and through the cooperation of the thin pipe and the liquid inlet pipe, the problem that in the prior art, the buttocks of the puerpera cannot be collected is solved. In the prior art, due to the fact that a parturition pad in an area in contact with the buttocks is slightly sunken, part of amniotic fluid or blood flows to the area to be in contact with the buttocks, and in the prior art, the amniotic fluid or the blood in the area is either adsorbed away through a water absorption layer to reduce discomfort of a puerpera, or is not treated, so that the parturition pad can be used for absorbing the amniotic fluid or the blood in the area to be in contact with the buttocks. Obviously, the amniotic fluid or the bloody water cannot be accurately collected in any mode.

The invention discloses application of CTSB as a congenital maxillofacial deformity diagnostic marker in preparation of a diagnostic reagent, and relates to the technical field of biomedicine.Early auxiliary diagnosis of congenital maxillofacial deformity is achieved by detecting the mRNA expression level or protein expression level of CTSB in a biological sample, and when the expression level is higher than that of a healthy control by two times or above, the CTSB can be used as the diagnostic marker for the congenital maxillofacial deformity. And the congenital maxillofacial deformity risk is prompted. The biological sample comprises blood, saliva, amniotic fluid or a palate embryo mesenchymal cell tissue sample. Early auxiliary diagnosis of congenital maxillofacial deformity can be realized by detecting the expression level of CTSB in a biological sample, and targeted therapeutic drugs can be developed by inhibiting the activity or expression of CTSB. The problems that in the prior art, congenital maxillofacial deformity diagnosis lags behind, and treatment lacks specificity are solved, and a new theoretical basis and a new technical means are provided for prevention and treatment of congenital maxillofacial deformity.

Provided is a method for treating disorders or conditions related to erectile dysfunction. The method includes administering to a subject in need thereof a therapeutically effective amount of mesenchymal stem cells or secretome thereof, wherein the mesenchymal stem cells or secretome are derived from human amniotic fluid.

The invention discloses a fetal giant child prediction method and system based on machine learning in the field of medical health of artificial intelligence, and the method comprises the following steps: S1, data collection: collecting ultrasonic examination data and clinical feature data of a late pregnancy (greater than or equal to 37 weeks) single-fetal pregnant woman, and constructing an original data set; the ultrasonic examination data comprises fetal biparietal diameter (BPD), femur length (FL), abdominal circumference (AC), head circumference (HC), amniotic fluid index (AFI) and ultrasonic weight estimation, and the clinical characteristic data comprises pregnant woman pre-pregnancy body weight index (BMI), pregnancy body weight increment (GWG), examination week of pregnancy (GA) and fetal gender. The giant child prediction method based on machine learning provided by the invention has significant clinical application value and technical advantages, can effectively improve the prediction ability of fetal giant child, promotes the intelligent and precise development of the obstetrical field, and has important practical significance for improving the health level of mothers and infants.

This utility model discloses a membrane rupture forceps with a splash guard, comprising a first forceps body, a second forceps body, and a shield. The first forceps body and the second forceps body are rotatably connected by a connecting device. The first forceps body includes a first handle and a first jaw and a first gripper located at both ends of the first handle. The second forceps body includes a second handle and a second jaw and a second gripper located at both ends of the second forceps body. One end of the shield is an open end, and the other end of the shield has a groove extending radially along the open end. The first jaw and the second jaw protrude from the open end through the groove. Sliding elements are provided on both the first handle and the second handle, and the first handle and the second handle are slidably connected within the groove along its length direction via the sliding elements. This utility model, by incorporating a splash guard, prevents amniotic fluid from splashing onto the faces and bodies of medical personnel, thus protecting their health.

The utility model discloses a three-way suction tube which comprises a three-way valve, the three-way valve comprises a shell, a first connector, a second connector and a third connector are arranged on the peripheral side of the shell respectively, the end of the first connector is connected with a liquid inlet tube, the end of the second connector is connected with a first liquid outlet tube, the end of the third connector is connected with a second liquid outlet tube, and a valve body is arranged in the shell and can rotate. And the liquid inlet pipe is communicated with the first liquid outlet pipe or the second liquid outlet pipe. By arranging the liquid inlet pipe, blood and amniotic fluid can be sucked, and by arranging the first liquid outlet pipe and the second liquid outlet pipe, the blood and the amniotic fluid can be sucked respectively, so that the operation bleeding amount can be estimated conveniently.

The utility model discloses an amniotic fluid puncture needle which comprises an inner needle seat, an outer needle seat, an outer needle tube, an inner needle, a rubber plug, a protruding part, a suction hole and a clamping protrusion. By pushing the inner needle base, the inner needle ejects the rubber plug out of the outer needle tube, when the inner needle ejects the rubber plug to the clamping protrusion, the inner needle base is pulled out, the outer needle base is connected with an external suction device, amniotic fluid can enter through the suction hole of the outer needle base and is extracted and collected, and the situation that a fetus is scratched in the collection process is avoided through pushing out of the rubber plug.

To provide methods for forming mature cardiomyocytes.SOLUTION: Disclosed herein are methods of using a cell-derived extracellular matrix derived in-vitro from cells isolated from amniotic fluid (AFC-ECM) for the maturation of immature cardiomyocytes derived from human induced pluripotent stem cells (immature hiPSC-CMs) in culture, forming mature cardiomyocytes. Also disclosed herein is a cell construct comprising a monolayer of these mature cardiomyocytes on an AFC-ECM useful for cardiotoxicity and / or proarrhythmic screening assays of drug compounds. Also disclosed herein are methods for determining the cardiotoxicity and / or proarrhythmic effect of a drug compound in vitro using such cell constructs.SELECTED DRAWING: None

The invention discloses an antenatal diagnosis amniotic fluid puncture collection device, and belongs to the technical field of gynaecology and obstetrics medical treatment. The puncture collection device comprises a positioning sleeve, the positioning sleeve is integrally of a kidney-shaped structure, a sliding block is slidably connected to the positioning sleeve, a round hole is formed in the middle of the sliding block, an outer cylinder is connected to the upper surface of the round hole, and the bottom of the outer cylinder is communicated with the round hole; a sampling barrel is arranged in the outer barrel, a needle tube is connected to the bottom of the sampling barrel, the sampling barrel penetrates through the circular ring, a locking column is connected to the upper end of the sampling barrel through a bearing, a connecting lug is installed on one side of the positioning sleeve and connected with a bandage, holes are formed in the bandage at equal intervals, a fixing lug is installed on the other side of the positioning sleeve, and a locking mechanism is arranged on the fixing lug. The arc-shaped movable groove provides a sliding path for the sliding block, the limiting block on the side face of the sliding block is matched with the sliding groove in the inner wall of the movable groove, the sliding direction of the sliding block can be limited, deviation is avoided, a medical worker can push the sliding block to drive a needle tube to stably move in the movable groove, the optimal puncture point is accurately found, and deviation caused by the puncture point is reduced.

The invention discloses an obstetrical membrane rupture device, and belongs to the technical field of medical instruments, the obstetrical membrane rupture device comprises a sleeve, the end of the sleeve is hinged to a cover body mechanism, the interior of the sleeve is in threaded connection with a pushing mechanism, and the pushing mechanism and the interior of the sleeve are in sliding connection with an extraction mechanism; the device comprises a sleeve, a pulling mechanism is arranged in the sleeve, an expanding mechanism is slidably connected in the sleeve, the pushing mechanism is used for pushing the pulling mechanism and the expanding mechanism in the sleeve, a limiting mechanism is slidably connected to the surface of the pulling mechanism, and the limiting mechanism is used for disassembling the pulling mechanism in the pushing mechanism and the expanding mechanism. A limiting mechanism enables the extraction mechanism to be detachable in the sleeve, the extraction pipe can be moved out of a third through hole and a through groove by pushing a pushing ring front and back, an amniotic fluid sample in the extraction pipe can be independently transferred, the sleeve is prevented from being transferred together, and therefore the risk of cross infection is reduced, and the safety of membrane rupture work is improved.

The invention belongs to the technical field of biological medicine, and particularly relates to a preparation method and application of an amniotic fluid active complex. According to the method, inherent physical and chemical differences of different components in amniotic fluid are utilized, through a series of physical steps, the components are firstly and mildly grouped and enriched according to categories, and then the components are guided to be self-assembled again under controllable conditions to form a composite particle with a compact structure. The natural aggregation state of active ingredients in a living body before secretion or action is simulated, so that the multi-element active ingredients which naturally coexist and interact in amniotic fluid are efficiently captured and transferred as a complete functional unit, the natural ingredient spectrum is not damaged, and the original advanced structure and function are not lost. The invention provides application of an amniotic fluid active complex (RSC) in treating or preventing joint diseases or symptoms. The RSC has obvious effects in promoting cartilage matrix synthesis, inhibiting moderate and mild osteoarthritis and relieving pain.

Artificial womb (10) for the care of a premature infant (F) in particular until its lungs are mature or it is ready for birth, with - a reservoir (120) with a wall (121) for receiving the premature infant (F) and amniotic fluid (W); - an artificial placenta (150) with a connector (152) for connecting the umbilical cord (N) of the premature infant (F), wherein the artificial placenta (150) comprises at least one membrane (151) through which oxygen from the ambient air of the artificial womb (10) or from an oxygen reservoir (155) is supplied to the artificial placenta (150) for oxygenating the blood of the premature infant (F); and - a housing (110) in which the reservoir (120) and the artificial placenta (150) are arranged, wherein the housing (110) in particular has a compact shape, wherein the artificial uterus (10) is portable.

The invention relates to the technical field of medicines, in particular to application of dimethyl fumarate in promoting proliferation of amniotic fluid stem cells and application of dimethyl fumarate in promoting proliferation of amniotic fluid stem cells. The invention discloses an application of dimethyl fumarate as an NRF2 expression promoter. The administration concentration of the dimethyl fumarate is 2.5 to 10 M; the dimethyl fumarate promotes NRF2 expression, protects the amniotic fluid stem cells, reduces oxidative damage and accelerates proliferation of the amniotic fluid stem cells, the cell culture time is shortened to 72 hours, and the DMF monovalent value is 1 / 40 of that of a growth factor.

The invention relates to an amniotic fluid cell culture medium and a preparation method thereof, and belongs to the technical field of cell culture mediums. The culture medium comprises a basic culture medium, a fermented animal polypeptide compound and auxiliary components, the fermented animal polypeptide compound is formed by compounding fermented bovine bone collagen peptide and fermented sheep placenta peptide according to a specific proportion, and polypeptide is subjected to bacillus subtilis fermentation, enzymolysis and purification and then passes through a 0.22 mu m polyether sulfone filter membrane terminal for sterilization. By utilizing the synergistic effect of the fermented animal polypeptide, the proliferation rate and metabolic activity of the amniotic fluid cells are effectively improved, meanwhile, stable physical and chemical properties, standard sterility, definite components, small batch difference and no need of adding fetal calf serum and plant-derived components are ensured, and the method is suitable for amniotic fluid cell culture in prenatal diagnosis.

The invention discloses an early warning method for amniotic fluid rupture of a pregnant woman. The early warning method comprises the following steps: S1, detecting a liquid signal of a target area in real time through a sensor array arranged on underpants; s2, processing the liquid signal, and identifying the liquid type based on a multi-modal judgment logic; s3, when the amniotic fluid is judged to be amniotic fluid, an early warning response is triggered. Through the scheme, the method has the advantages of high accuracy, real-time performance, safety, practicability, comfort and the like. The invention further discloses a pregnant woman amniotic fluid rupture early warning system and underpants.

The amniotic fluid sampling device comprises a sampler, a piston push rod is movably arranged in the sampler, a puncture needle is arranged on the lower portion of the sampler in a communicating mode, a plurality of V-shaped patterns are sequentially arranged on the surface of the puncture needle from bottom to top at equal intervals, and the V-shaped patterns are integrally distributed in a spiral rising track shape. Each V-shaped pattern comprises an inclined edge I and an inclined edge II which are oppositely distributed. By arranging the V-shaped grains, the side hole, the inclined edge I and the inclined edge II, firstly, a doctor keeps the tip of the puncture needle to gradually go deep by adopting a constant-speed rotary needle inserting method, and in the rotary needle inserting process of the puncture needle, the whole tip of the V-shaped grains is just consistent with the needle inserting direction of the needle tip; meanwhile, the cooperation of rotary needle insertion and a spiral ascending track formed by a plurality of V-shaped patterns is adopted, so that tissue cutting by the needle tip is more tidy, the puncture smoothness of the needle body is assisted to be improved, and residues of maternal cells on the needle body are reduced.

The invention belongs to the technical field of medical instruments, and particularly relates to an amniotic fluid sampler for gynaecology and obstetrics, which comprises a puncture frame, an adsorber, a puncture outfit and a controller. The B-ultrasonic probe and the puncture needle are flexibly adjusted and fixed through the installer, and accurate positioning is ensured; the adsorber stably adsorbs the device to the abdomen of a patient through a negative pressure channel and a rubber air cushion, and displacement during operation is prevented; the puncture outfit adopts a specially designed puncture needle and comprises an outer sleeve and a rotatable sampling needle core, so that maternal blood or tissues are prevented from being carried, and the risk of sample pollution is reduced; the controller controls the driving motor through a needle feeding button and a needle withdrawing button, the puncturing depth and speed are automatically adjusted by combining a worm gear, a worm and a lead screw mechanism, and manual operation errors are reduced. According to the whole device, automatic control, stable fixing and clean sampling of amniotic fluid sampling are achieved through the structure, and the detection accuracy and operation convenience are improved.