6 results about "Androgen level" patented technology

The present invention relates to modified recombinant human MIS protein which has improved cleavage and increased bioactivity and increased potency as compared to wild-type human MIS protein. Other aspects of the invention relate to methods to prevent and treat cancers, such as cancers that express the MIS receptor type II (MISRII) by administering to a subject a composition comprising a recombinant human MIS protein. Another aspect of the present invention relates to methods to lower plasma androgen levels in a subject, and / or for the treatment of a subject with a disease characterized by excess androgen. Another aspect provides pharmaceutical compositions and kits and methods for use comprising a recombinant human MIS protein. Another aspect of the present invention relates to methods to decrease the dose of a chemotherapeutic agent by administering the chemotherapeutic agent with the recombinant MIS protein that lowers the effective dose of the chemotherapeutic agent.

The present invention relates to modified recombinant human MIS protein which has improved cleavage and increased bioactivity and increased potency as compared to wild-type human MIS protein. Other aspects of the invention relate to methods to prevent and treat cancers, such as cancers that express the MIS receptor type II (MISRII) by administering to a subject a composition comprising a recombinant human MIS protein. Another aspect of the present invention relates to methods to lower plasma androgen levels in a subject, and / or for the treatment of a subject with a disease characterized by excess androgen. Another aspect provides pharmaceutical compositions and kits and methods for use comprising a recombinant human MIS protein. Another aspect of the present invention relates to methods to decrease the dose of a chemotherapeutic agent by administering the chemotherapeutic agent with the recombinant MIS protein that lowers the effective dose of the chemotherapeutic agent.

The invention discloses an application of a sheep placenta extract in preparation of a medicine for improving polycystic ovarian syndrome, and relates to the technical field of biological medicine, the medicine is used for improving endocrine disorder and abnormal inflammation caused by the polycystic ovarian syndrome, and particularly for reducing the plasma androgen level and increasing the plasma estrogen level and the plasma progestational hormone level; the level of an inflammatory factor TNF-alpha is reduced, and the level of an inflammatory factor IL-10 is increased. The sheep placenta extract can improve ovarian polycystic lesions caused by polycystic ovarian syndrome (PCOS) in a targeted manner, and experiments show that after intervention of the sheep placenta extract, the number of macroscopic cystic follicles in rat ovary is reduced, the weight of the ovary with abnormal weight gain is remarkably reduced, the cystic follicle ratio in ovarian histopathology detection is greatly reduced, and the sheep placenta extract has a good application prospect. The ratio of the number of the corpus luteum is closer to normal, and the pathological injury of the polycystic ovarian syndrome is repaired from the organ level.

The invention discloses a keratin peptide compound with an effect of promoting hair growth and application of the keratin peptide compound, and belongs to the technical field of health food for promoting hair growth. The keratin peptide compound provided by the invention does not have any toxic or side effect; the hair growth of physiological alopecia model mice and androgen alopecia model mice can be effectively promoted, the test mice have no abnormal phenomenon during the test, and the safety is good; on one hand, the health degree of hair follicle cells and scalp can be improved, and a suitable growth environment is provided for hair growth; on the other hand, the absorption and utilization capability of the body on nutrient substances is improved, and raw materials are provided for hair growth; the main hidden danger of causing non-physiological alopecia is radically solved by adjusting the androgen level in the body; meanwhile, the growth period of hair is prolonged, the good effect of promoting hair growth is achieved, and a virtuous circle is formed.

The application discloses a system for predicting and evaluating the probability of in vitro fertilization pregnancy based on androgen response elasticity, which comprises a data acquisition module and an androgen response elasticity calculation module; the data acquisition module is used for acquiring the age of a subject and androgen levels at different stages; and the androgen response elasticity calculation module is used for calculating androgen response elasticity parameters according to the androgen levels at different stages, and obtaining the probability of in vitro fertilization pregnancy during ovary stimulation according to the androgen response elasticity parameters and the age of the subject.