53 results about "Anti-agents" patented technology

The invention provides an efficient flame-retardant film and a production process thereof, and relates to the technical field of flame-retardant films. An efficient flame-retardant film comprises a surface layer, a core layer and an inner layer. The surface layer is prepared from the following raw materials in parts by mass: 10 to 40 parts of copolymerized PP, 7 to 36 parts of a flame retardant, 0.4 to 1.5 parts of an anti-UV agent, 0.01 to 0.1 part of an anti-aging agent, 0.5 to 3 parts of an anti-sticking agent and 0.2 to 3 parts of titanium dioxide master batch. The flame-retardant film provided by the invention has excellent flame retardance.

The present invention relates to pathogen cleaning and simulation of pathogen spreading. More particularly, some implementations of the described invention relate to systems and methods for spraying materials in a manner that mimics the spreading of pathogens from coughing or sneezing. Some implementations further relate to using a non-aerosol sprayer that produces both a mist and droplets of a mixture containing water, a fluorescent marker, a surfactant, and an antifoaming agent. In some cases, the pump sprayer defines an internal compartment that includes the mixture. In some cases, the sprayer further includes a pump mechanism that is configured to be pumped to compress a gas within the compartment and a release valve that is configured to release pressure within the compartment through a spray nozzle of the sprayer such that droplets and mist of the mixture are sprayed from the nozzle. Other implementations are also described.

Composition and methods for treating Sjögren's disease are provided herein using compositions comprising anti-FcRn agents.

The invention discloses an anti-UV and anti-aging master batch for a pesticide-resistant PE net and a preparation method of the anti-UV and anti-aging master batch, the master batch comprises the following components in percentage by mass: 70-80 wt% of matrix resin PE, 2-4 wt% of an anti-UV agent, 1-2 wt% of an antioxidant, 10-15 wt% of a pesticide-resistant agent and 5-12 wt% of an adjuvant, and the invention relates to the technical field of master batches for PE nets. Through scientific and reasonable proportioning, the anti-UV agent, the antioxidant, the pesticide-resistant agent and other additives have a synergistic effect, the pesticide resistance, ultraviolet resistance and aging resistance of the PE net are remarkably improved, uniform distribution of the additives in a PE matrix is guaranteed by using the dispersing agent and the plasticizer, and therefore the overall performance of the master batch is improved, and the service life of the PE net is prolonged. The master batch provided by the invention is suitable for production of various PE nets, and is especially suitable for agricultural protective nets which are used for a long time in high-pesticide and high-ultraviolet environments.

The present disclosure provides combinations of anti-CD19 agents and B cell targeting agents and methods of treating subjects having B cell malignancies with combinations of anti-CD19 agents and a B cell targeting agents.

The invention discloses an immunochromatography test strip and a kit for rapidly detecting human urinary nuclear matrix protein 22, the test strip comprises a sample pad, a combination pad, a nitrocellulose membrane and a water absorption pad which are connected in sequence, the nitrocellulose membrane is provided with a detection line and a quality control line in sequence, the detection line is coated with an NMP22 antibody treated by a blocking agent, and the quality control line is coated with a quality control line. The quality control line is coated with a DNP antigen treated by a blocking agent, and the blocking agent comprises the following components in percentage by mass: 1% of an anti-heterotropism antibody agent, 0.2 mg / mL of an anti-rheumatoid factor agent, 1% of an anti-HAMA agent, 0.02 mol / L of PBS, 5% of sucrose and 0.1% of PC300. The immunochromatography test strip for rapidly detecting the human urinary nuclear matrix protein 22 is high in detection speed, capable of obtaining a detection result within 1-15 min, free of instruments, easy to operate, low in price, suitable for basic medical institutions and suitable for popularization and self-detection.

Provided are pharmaceutical compositions and methods of treating or preventing edema, using an anti-T cell agent, an anti-TGF-β1 agent, or an anti-angiotensin agent, preferably a combination of at least two such agents. The pharmaceutical compositions can be formulated for systemic or local administration, and are preferably administered topically.

Methods are provided for targeting cells for depletion, including without limitation tumor cells such as solid tumor cells, in a regimen comprising contacting the tumor and immune effector cells with an effective dose of an anti-MSDC agent that reduces the abundance, immunosuppressive activity, or tumor recruitment of CXCR2+ granulocytic-myeloid derived suppressor cells, for example, an inhibitor of CXCR2; in combination with an effective dose of an inhibitor of CD47 / SIRPα signaling.

This invention provides compounds and methods of application that possess both broad-spectrum antifungal activity and plant-induced resistance, belonging to the field of agricultural technology. It addresses the problem that "traditional pure immune inducers must be applied before disease onset, making it difficult to meet the full-cycle control needs of disease prevention and treatment in the field." Compared to the previously developed PC1 and PC20, the two compounds of this invention, 2,4-dibromo-6-nitrophenol and 7-deazon-2'-deoxy-7-iodoadenosine, can both inhibit the growth of rice blast fungus and significantly improve rice resistance to rice blast through foliar spraying, meeting the full-cycle control needs of disease prevention and treatment in the field. Furthermore, these two compounds can directly inhibit the growth of various fungal pathogens such as peanut white mold, tomato gray mold, wheat scab, rice bakanae disease, rice false smut, mango malformation, and banana wilt.

Some embodiments relate to a sustained release silica hydrogel composite comprising an anti-complement agent and methods of using same to treat ophthalmological conditions. The anti-complement agent may be an anti-C5 agent comprising a C5-specific aptamer.

The present invention provides an application of 2-bornanol in antibacterial, promoting plant growth, and / or inducing plant resistance, and also provides a method for antibacterial, promoting plant growth, and / or inducing plant resistance, as well as a biological pesticide, a plant resistance inducer, and a plant growth regulator. The present invention directly clarifies the feasibility of 2-bornanol as a plant growth regulator, a resistance inducer, and a biological pesticide and is proven in field trials. Compared with other methods of biological pesticides and growth regulators, the application and method of the present invention have the advantages of simple operation, low requirements for outdoor spraying conditions, and can be popularized and applied in the field.

The present disclosure relates to novel encapsulant film compositions that provide anti-PID properties while maintaining good cure, adhesion, volume resistivity properties. The composition comprises: a) a polyolefin polymer; b) an organic peroxide; c) a silane adhesion promoter; and d) a crosslinking aid; and e) an anti-PID agent.

Provided herein are uses of T cells, e.g., chimeric antigen receptor (CAR) T cells, for treating a tumor or a cancer (such as B cell related cancer, e.g., multiple myeloma) wherein the subject being treated has previously received a topoisomerase inhibitor, a proteasome inhibitor, an anti-CD38 agent, an immunomodulatory agent, or an anti-SLAMF agent therapy.

Provided are methods and compositions for treatment of angiogenic disorders using anti-VEGF agents. The anti-VEGF agents comprise VEGF binding domains and have the ability to bind vitreous. Provided are exemplary embodiments of Fc-IgG fusion proteins with VEGF binding domains with strong heparin-binding characteristics, strong inhibition of VEGF mitogenic activity, and improved pharmacokinetics, namely longer half-lives of the anti-VEGF agents and consequently less frequent dosing.

Compositions and methods for making and using anti-TLR9 agents, for example, monoclonal antibodies, TLR9-binding antibody fragments, and derivatives are described, as are kits, nucleic acids encoding such molecules, diagnostic reagents and kits that include anti-TLR9 agents, and methods of making and using the same.

To provide methods for treating diseases.SOLUTION: The present disclosure provides prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosine nucleosides, and compositions, methods and kits thereof. Such compounds can be useful for treating virus infections including human immunodeficiency virus. The compounds have the following formula (I). Provided herein are compounds functioning as antiviral agents (in some embodiments, as anti-HIV agents), pharmaceutical compositions comprising such a compound and optionally in combination with one or more (e.g., two, three or four) additional therapeutic agents, and methods for using such compounds and compositions. Embodiment of every disclosed compound includes pharmaceutically acceptable salts and stereoisomers thereof or a mixture of the stereoisomers.SELECTED DRAWING: None

The present disclosure relates to dosage regimes of anti-CD19 agents, in particular an anti-CD19×anti-CD3×anti-CD2 trispecific agent administered intravenously (i.v.) and subcutaneously (s.c.), and their use for treating diseases and disorders associated with expression of CD19 such as B cell malignancies, in particular relapsed and / or refractory B-cell malignancies.

The present application discloses a method for preventing and treating flue-cured tobacco virus disease, belonging to the field of plant protection. The method comprises (1) prevention: applying agents during the seedling stage, before transplanting, after transplanting, and during the field stage of tobacco growth; during the seedling stage: applying guanidine-copper acetate before thinning, replanting, and weeding; applying amino oligosaccharides and antiviral microbial agents before sealing the trays; applying cinclostrobin acetate solution after sealing the trays and before cutting the leaves; applying ningnanmycin and amino oligosaccharides before and after transplanting; applying insecticides mixed with plant resistance inducers, antiviral microbial agents, trace elements, and foliar fertilizers from one week after transplanting the seedlings to the stage of clustering; (2) treatment of the disease. The method prevents flue-cured tobacco virus disease by applying antiviral agents early in the whole growth stage of tobacco; and combining the antiviral agents with other specific agents to improve tobacco plant resistance, reduce the incidence of viral diseases, and improve the cure rate of viral diseases.

Compositions and methods for making and using anti-TLR9 agents, for example, monoclonal antibodies, TLR9-binding antibody fragments, and derivatives are described, as are kits, nucleic acids encoding such molecules, diagnostic reagents and kits that include anti-TLR9 agents, and methods of making and using the same.

The invention discloses an immunochromatographic test strip and a kit for rapid detection of human urine nuclear matrix protein 22, the test strip includes a sample pad, a conjugate pad, a nitrocellulose membrane and a water-absorbing pad connected in sequence, a detection line and a quality control line are sequentially arranged on the nitrocellulose membrane, the detection line is coated with a blocker-treated NMP22 antibody, the quality control line is coated with a blocker-treated DNP antigen, the blocker includes 1% anti-heterophilic antibody agent, 0.2mg / mL anti-rheumatoid factor agent, 1% anti-HAMA agent, 0.02mol / L PBS, 5% sucrose and 0.1% PC300, and the above percentages are mass percentages. The immunochromatographic test strip for rapid detection of human urine nuclear matrix protein 22 of the present invention has a fast detection speed, and the test result is obtained in 1-15min, without the need for an instrument, simple operation, low price, and is suitable for primary medical institutions, and is suitable for popularization and self-testing.

The present invention provides an anti-insect culture medium, comprising a shaped medium having a plurality of pores interconnected to each other, and an anti-insect agent evenly dispersed and fixed in the pores; wherein the shaped medium comprises at least one culture medium solid, the anti-insect agent comprises an anti-insect ingredient, and the anti-insect agent is a sustained-release formulation. The anti-insect culture medium of the present invention can provide a long-term and complete anti-insect efficacy to plant roots. The present invention further provides an anti-insect method, which reduces the amount of anti-insect agents and avoids the inconvenience of regular application.

The invention belongs to but not limited to the technical field of microbial application, and discloses a plant immune resistance inducer as well as a preparation method and application thereof. Comprising an Aava fermentation extract, a surfactant, a defoaming agent, an anti-freezing agent, a thickening agent and a solvent, the Aava fermentation extract is a concentrate of an endophytic alternaria Aava fermentation filtrate, the surfactant is sodium dodecyl sulfate, the defoaming agent is tributyl phosphate, the antifreezing agent and the thickening agent are glycerol, and the solvent is water. The Aava fermentation extract disclosed by the invention is realized by stimulating autoimmunity of kiwi fruit plants, has no any sterilization effect on canker pathogens, and is not easy to generate drug resistance; and the compound has a certain broad spectrum, and has an induced resistance effect on gramineous plant wheat, rosaceae plant apple and solanaceae plant tobacco. When the Aava fermentation extract is used as a plant immune resistance inducer, the defense capability of plants can be improved, and the canker resistance of the plants can be remarkably improved.

To find compounds derived from natural products excellent in anti-metabolic syndrome action, skin-whitening action, anti-aging action, hair growth action, anti-inflammatory action or liver function-improving action, and provide: an anti-metabolic syndrome agent, a skin-whitening agent, an anti-aging agent, a hair growth agent, an anti-inflammatory agent and a liver function-improving agent that contain the compounds as active ingredients; and oral compositions, skin cosmetics and hair cosmetics comprising the compounds derived from natural products.SOLUTION: Compounds 1 to 3 represented by the general formula (I) in the figure are used.SELECTED DRAWING: None

The present invention relates to the treatment of locally advanced or metastatic urothelial carcinoma (mUC) in a patient suffering from FGFR altered mUC and having disease progression during or after one or more prior treatments comprising a checkpoint inhibitor, in particular an anti-PD-(L) 1 agent, with erdatinib.

A hair care composition is disclosed comprising an anti-dandruff agent selected from piroctone olamine, selenium sulfide and mixtures thereof and a copolymer comprising acrylamidopropyltrimonium chloride, wherein the weight ratio of the amount of the copolymer to the amount of the anti-dandruff agent is in the range of from 1:5 to 1:1.

The invention relates to the technical field of chemical production, in particular to high-dispersion pearlescent color oil for plastics and a preparation method thereof.The pearlescent color oil comprises 50%-97.5% of grease, 2%-50% of pearlescent toner and 0-10% of auxiliaries, the grease is a compound system of carbomer and the like, and the auxiliaries comprise a dispersing agent, an antioxidant and an anti-UV agent; the preparation method comprises the steps of raw material pretreatment, mixing, quantitative dispersion and curing post-treatment, and the dispersion uniformity coefficient sigma is controlled to be smaller than or equal to 0.3 by determining the dispersion rotating speed and time. Through raw material optimization and process quantitative regulation and control, the color oil dispersion stability is improved, the color oil can adapt to PP, PET, ABS and other plastics, the appearance can be ensured to be uniform and free of flow lines under the condition of low addition amount, and the color oil has good weather resistance. The process is high in operability, does not need special equipment, is suitable for industrial mass production, and provides a high-quality solution for plastic decoration.

The invention discloses an anti-aging, anti-bending flame-retardant composite cable material and a preparation method thereof, and belongs to the field of composite cables. The invention is measured by weight, and the proportions of each component are as follows: 55-68 parts of HDPE, 11-17 parts of CPE, 32-36 parts of EPDM, 6-12 parts of polymer modifier, 5-18 parts of toughening agent, 0.5-3 parts of plasticizer, 2-5 parts of stabilizer, 15-25 parts of filler, 7-15 parts of flame retardant, 0.2-1.5 parts of lubricant, 1.5-2 parts of coupling agent, 0.4-1 parts of antioxidant, and 0.5-1 parts of UV resistance agent. The cable material prepared by the invention uses EPDM as a part of the base material, and adds fillers including carbon black, heavy calcium carbonate and zinc borate, which is conducive to subsequent processing, shortens the processing cycle, and is suitable for large-scale mass production.

This invention provides a halogenated flame-retardant V-0 polyolefin masterbatch for silane self-crosslinking materials and its preparation method. It comprises the following raw material components in parts by weight: 20-23 parts LDPE; 53-56 parts brominated flame retardant; 17-19 parts antimony flame retardant; 0.8-1.2 parts coupling agent; 2-3 parts UV stabilizer; 1.4-1.6 parts lubricant; and 0.4-0.5 parts antioxidant. The LDPE has a melt flow index of 1.5-2.5 g / 10 min. The combined use of these components produces a synergistic effect: even with relatively low addition levels, the resulting silane self-crosslinking material achieves a UL 94V-0 flame retardant rating, effectively reducing costs.

This disclosure relates to a novel encapsulant film composition that provides anti-PID properties while maintaining good performance in terms of curing, adhesion, and volume resistivity. The composition comprises a) a polyolefin polymer, b) an organic peroxide, c) a silane adhesion promoter, and d) a crosslinking aid, and e) an anti-PID agent.