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44 results about "Anticancer peptide" patented technology
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Anticancer peptide as well as preparation method and application thereof
The invention relates to the field of biological medicines and particularly relates to an anticancer peptide. The anticancer peptide is selected from one or two of the following sequences in the following groups: (a) an amino acid sequence expressed as SEQ ID NO: 1; and (b) an amino acid sequence expressed as SEQ ID NO: 2. The anticancer peptide has extremely obvious anticancer activity, is low in toxicity and is relatively safe to human body. The invention also relates to a preparation method of the anticancer peptide and application of the anticancer peptide to preparation of anticancer medicines.
Owner:贵州源熙生物研发有限公司
Antimicrobial fusion peptide as well as preparation method and application thereof
ActiveCN108610428AEasy accessImprove anti-cancer effectAntibacterial agentsPeptide/protein ingredientsKanamycinFreeze-drying
The invention discloses an antimicrobial fusion peptide. The peptide chain sequence of the antimicrobial fusion peptide is SISLLYGRKKRRQRRR. The invention further provides another antimicrobial fusionpeptide of which the peptide chain sequence is YGRKKRRQRRRSISLL. The invention provides a preparation method of the antibacterial fusion peptide. The preparation method comprises the following steps:coupling corresponding amino acids from the carbon terminal to the nitrogen terminal according to the sequence of a target antibacterial fusion peptide; washing and blowing deprotection groups to dryness after coupling of the nitrogen-terminated amino acid is completed; cutting, carrying out suction filtration and fully washing and centrifuging by using ice diethyl ether to remove supernatant forthree times or above; dissolving the dried solid powder by using deionized water, separating, purifying, collecting main peak effluent and carrying out freeze drying to obtain the target antimicrobial fusion peptide. The invention further discloses application of the antimicrobial fusion peptide in medicines. According to the preparation method disclosed by the invention, the fusion peptide withan antibacterial effect is obtained on the basis of anticancer peptide; in addition, the antibacterial effect of the antimicrobial fusion peptide is close to the antibacterial effect of a powerful antimicrobial drug kanamycin, so that a basis is provided for further research and development of drugs with dual effects of resisting cancer and bacteria.
Owner:西安华企众信科技发展有限公司
Amolops Hainan ensis anticancer peptides Hainanenin-1 as well as gene and application thereof
ActiveCN103755796AGood antitumor activityLess prone to multidrug resistancePeptide/protein ingredientsMicrobiological testing/measurementChemical synthesisAmolops
The invention belongs to the field of biomedicine and in particular relates to an Amolops Hainan ensis anticancer peptides Hainanenin-1 as well as a gene and an application thereof. A sequence of the anticancer peptides Hainanenin-1 is shown by amino acid in SEQ ID No. 1. The Hainanenin-1 is small in molecular weight, has a simple structure, only contains one disulfide bonds, is convenient to carry out chemical synthesis and genetic engineering preparation, is applied in preparing an anticancer drug, has broad-spectrum antineoplastic activity, has obvious killing action to MCF (Human Breast Cancer)-7 cells, has obvious growth inhibition action to other various cancer cells, and also has the beneficial effects of low hemolytic activity, nearly no toxicity to normal cells and the like. Most important of all, by adopting Hainanenin-1, due to the special cancer cell killing mechanism of Hainanenin-1, the tumor multi-drug resistance generated when traditional chemical drugs are applied is difficult to generate.
Owner:DALIAN UNIV OF TECH
Anticancer peptide
A polypeptide and methods of using the polypeptide for treating malignancy by administering to a subject a composition of the polypeptide. Pharmaceutical compositions of the polypeptide.
Owner:TEXAS BOARD OF REGENTS UNIV OF
Anticancer peptide containing poly-L-histidine as well as preparation and application thereof
PendingCN106749522ASimple structureNo side effectsPeptide/protein ingredientsPeptide preparation methodsCytotoxicityTherapeutic effect
The invention discloses an anticancer peptide containing poly-L-histidine as well as preparation and application thereof and belongs to the technical field of development and application of antitumor drugs. An amino acid sequence of the poly-L-histidine comprises a plurality of histidines; the poly-L-histidine has efficient antitumor activity. Through the adoption of a polypeptide solid phase synthesis technique, a series of peptides which are rich in histidine and have membrane cracking activity and antitumor activity are built; the peptides have effects of killing cancer cells and is especially capable of killing ovarian cancer SKOV-3 cells under the acid condition with high selectivity; cytotoxicity experiments of in-vitro ovarian cancer SKOV-3 cells, lung cancer A549 cells and breast cancer MCF-7 cells and the tumor-inhibiting experiment of mouse in-vivo ovarian cancer SKOV-3 tumor show that the poly-L-histidine peptide has excellent effects of treating ovarian cancer, lung cancer and breast cancer.
Owner:EAST CHINA UNIV OF SCI & TECH
Novel Analogues of Antimicrobial and Anticancer Peptide Synthesized and Produced from Gaegurin 5
ActiveUS20100105626A1High antibacterial activityImprove securityAntibacterial agentsBiocideMicroorganismRana rugosa
The present invention is related to antimicrobial and anticancer peptide engineering using Gaegurin 5 isolated from Korean frog (Rana rugosa), which have smaller structure compared with previously known Gaegurin peptide and shows potent antimicrobial and anticancer activity. Specifically, the antimicrobial and anticancer peptide of the present invention synthesized from the shortest length of Gaegurin 5, show potent antimicrobial activity against gram positive and negative strains, good safety with very low hemolytic activity and favorable advantages such as drug absorption and drug transportation due to its advantageous structural property, which can be useful as a potent antimicrobial or anticancer agent.
Owner:XCELL THERAPEUTICS INC
Nitrogen and sulfur heterocyclic compound, preparation method and application thereof
InactiveCN102060802AReduce pollutionEasy to prepareAntibacterial agentsOrganic active ingredientsSulfurNitrogen
The invention relates to a nitrogen and sulfur heterocyclic compound, a preparation method and application thereof. Search shows that hairy clams contain a lot of active substances, such as anticancer peptides and polysaccharides, but no related technology discloses heterocyclic compounds in the hairy clams. In the invention, a nitrogen and sulfur heterocyclic compound, 1,5,9,13-tetrathia-2,6,10,14-tetraazacyclohexahecane, is extracted and separated from the hairy clams and has the molecular formula of C8H20N4S4. Experiment results show that the nitrogen and sulfur compound extracted and separated from the hairy clams has antibacterial effect, which indicates that the nitrogen and sulfur compound provided by the invention can be used as an antibacterial agent.
Owner:广西海洋研究所有限责任公司 +1
Conveying system of polypeptide-rare-earth material and preparation method and application
InactiveCN109731104AIncreased resistance to hydrolysisGrowth inhibitionPeptide/protein ingredientsPharmaceutical non-active ingredientsCyclic peptideNanoparticle
The invention discloses a conveying system of a polypeptide-rare-earth material and a preparation method and application. The conveying system of the polypeptide-rare-earth material comprises a nanocluster (LDN), two different kinds of anticancer peptides (BIM and PMI) and one cyclic peptide iNGR. The nanocluster is formed through self-assembly of nano particles doped with lanthanide, and polypeptide BIM, PMI and iNGR are directly combined with the surface of the nanocluster through sulfydryl of cysteine. According to the conveying system of the polypeptide-rare-earth material, the resistanceof polypeptide medicine to protease hydrolysis is reinforced, in response to the reduction condition which exists in the tumor microenvironment, the polypeptide medicine is decomposed, growth of cancer cells is inhibited in vivo, and the material has good prospects in targeted treatment of the cancer.
Owner:苏州明基医院有限公司
Anticancer active peptide and application
InactiveCN107759678AImprove bioavailabilityHigh anticancer activityAntineoplastic agentsAnimals/human peptidesAmino acid replacementSolid tumor
The invention relates to an anticancer active peptide and application. By virtue of an amino acid replacement strategy, K in a Lycosin-I sequence is replaced by R, E is replaced by Q, and R-Lycosin-Iis obtained. The R-lycosin-I maintains the selectivity of the Lycosin-I and improves the cell toxicity activity for solid tumor cells. The anticancer peptide is active polypeptide toxin obtained by virtue of the modification of Lycosin-I, and the anticancer peptide contains 23 amino acid residues, the molecular weight is 2928.46Da, an isoelectric point is 12.12, and the amino acid sequence is: ArgGly Trp Phe Arg Ala Met Arg Ser Ile Ala Arg Phe Ile Ala ArgGlu Arg Leu Arg Glu His Leu.
Owner:HUNAN NORMAL UNIVERSITY
Analogues of antimicrobial and anticancer peptide synthesized and produced from Gaegurin 5
ActiveUS8076284B2High antibacterial activityPotent anticancer activityAntibacterial agentsBiocideMicroorganismAnticarcinogen
Antimicrobial and anticancer peptides engineered using Gaegurin 5 isolated from Korean frog (Rana rugosa), which have a smaller structure compared with previously known Gaegurin peptides and show potent antimicrobial and anticancer activity. Specifically, the antimicrobial and anticancer peptides synthesized from the shortest length of Gaegurin 5, show potent antimicrobial activity against gram positive and negative strains, good safety with very low hemolytic activity and favorable advantages such as drug absorption and drug transportation due to its advantageous structural property, which can be useful as a potent antimicrobial or anticancer agent.
Owner:XCELL THERAPEUTICS INC
Human ribosomal protein RPS6 subunit anticancer peptide fragment and application thereof
ActiveCN105131101AEasy to manufactureReduce production processPeptide/protein ingredientsAntineoplastic agentsRibosomal proteinNormal cell
Owner:侯万儒
Acid-responsive anticancer peptide and preparation method thereof
ActiveCN114230634AShield cytotoxicityImprove stabilityPowder deliveryPeptide/protein ingredientsHemolysisHigh plasma
The invention discloses an artificially synthesized anticancer peptide and an acid responsive nanoparticle precursor thereof. The nanoparticle is formed by connecting an anti-cancer peptide and an amphiphilic monomethyl polyethylene glycol-polypropylene glycol polymer through an acid-responsive chemical bond. Tests prove that the anti-cancer peptide can kill tumor cells through membrane rupture activity, and has the advantages of excellent broad-spectrum anti-cancer activity and drug resistance. The nanoparticles are selectively sensitive to a tumor subacid environment, can completely release anti-cancer peptides, and play an active role of a targeted tumor cell line. And the polypeptide has the advantages of hemolysis resistance, high plasma stability, low in-vivo systemic toxicity, systemic drug delivery and the like. The nanoparticle has a remarkable inhibition effect on various tumor cells including triple negative breast cancer, and particularly has a relatively good clinical application potential on drug-resistant triple negative breast cancer.
Owner:SUN YAT SEN MEMORIAL HOSPITAL SUN YAT SEN UNIV +1
Anticancer peptide recognition method based on fusion of random forests and related vector machine
PendingCN111524551ALow costImprove efficiencyArtificial lifeSequence analysisRandom forestAmino acid
The invention relates to an anticancer peptide recognition method based on r fusion of random forests and a related vector machine. The method comprises the following specific steps: carrying out feature extraction on the composition of amino acids, determining the average percentage of each amino acid in ACP and non-ACP, and determining the sequence features of ACP; constructing an RVM model by determining priori distribution and posteriori distribution and performing iterative computation; training the RVM model, calculating a posteriori mean value and a posteriori variance, and predicting atraining sample; and subjecting a given sample to feature sampling by adopting an RRVM algorithm using the given sample as a sample for RVM modeling, and when the feature of a new peptide chain is input, carrying out prediction by using the RVM model and judging whether the input new peptide chain is ACP or non-ACP. The method is superior to a traditional simple method adopted by most of researchers to identify ACP at present, solves the problem of low identification precision, and fully provides technical support for biological experiments to reduce the cost and improve efficiency.
Owner:HARBIN INST OF TECH
Antimicrobial and anticancer peptides & conjugates and compositions, methods, articles & kits relating thereto
ActiveUS20200190156A1Good transferabilityReducing eliminating from compositionPeptide-nucleic acidsPeptide/protein ingredientsAnticancer peptidePeptide
Peptides and conjugates are described herein, including peptides having antimicrobial and / or anticancer properties, as are compositions, articles, and kits comprising such peptides and conjugates, and methods for using the peptides and conjugates.
Owner:GEORGE MASON UNIVERSITY
Regrouped anticancer peptide, producing method and application of the same
InactiveCN101153056APrevent invasionInhibit transferPeptide/protein ingredientsPeptidesEscherichia coliAfter treatment
The present invention discloses an anti-cancer peptide with an amino acid sequence of SEQ ID NO.1, the expression body, the preparation method and the application in preparing anti-cancer drugs. The method comprises: a. the plasmid pTWIN2 carrier is used; a 13-peptide containing RGD sequence of OPN is inserted into the viscous end after treatment of endonuclease BspQI; the homocysteine TGC is added in designing of primer; the primer and the carrier after treatment of endonuclease are connected for a night at a temperature of 16 DEG C according to a ratio of 1 to 10 (molar ratio), through the denaturalization and annealing method of the primer; the recombinant plasmid pTWIN2-RGD can be prepared; b. the recombinant plasmid is digested by colicin and transferred into the colicin or Escherichia to induce and collect purified protein. The anti-cancer peptide of the present invention has good anti-cancer activity and is easy for synthesis.
Owner:HEBEI MEDICAL UNIVERSITY
Anticancer peptides
ActiveUS10550155B2Improve the level ofReduce in quantityPeptide/protein ingredientsDepsipeptidesAnti microbial peptideDimer
This invention provides new anticancer analogs of antimicrobial peptide temporin-SHa. New analogs (SEQ ID NOs: 2-6) of temporin SHa and, two different conjugates (7 & 8) comprising of monomeric and dimeric form of SEQ ID NO 4 with cancer targeting ligand were identified as anticancer peptides.
Owner:SHAHEEN FARZANA +6
Recombinant adenovirus expressing anticancer peptide CB1a as well as construction method and application thereof
InactiveCN107815442ARapid transfectionEasy to buildGenetic material ingredientsViruses/bacteriophagesCell growthTumor Cell Migration
The invention discloses a recombinant adenovirus expressing an anticancer peptide CB1a as well as a construction method and application thereof. According to the invention, the anticancer peptide CB1ais taken as a target gene to construct a recombinant adenovirus vector, and eukaryotic expression of the anticancer peptide CB1a is realized. By virtue of detection on relative activity on MTT cellsand a cell scratch assay, CB1a is verified to have the effect of inhibiting activity and migration of cancer cells in an in vitro experiment, so that growth of the cancer cells is inhibited. The construction method disclosed by the invention is high in efficiency and yield, and an unreported gene therapy system resistant to tumor cell migration and growth is provided.
Owner:WUHAN INST OF BIOENG
A modification method of natural anticancer peptide
The invention relates to the biotechnology field, specifically relates to an improvement method of natural anticancer peptide. The method comprises the design improvements at two stages by use of natural polypeptide as a template; in the design improvement at the first stage, a series of polypeptide derivatives are obtained by changing the percentage of polypeptide net charge and the hydrophobic residue in the polypeptide; in the design improvement at the second stage, the variety and the number of the screened polypeptide amino acid residue are unchanged, only the primary amino acid sequence is changed, so that the alpha-helix in the high-level structure is located at different positions or disappeared to obtain the series of polypeptide again. The anticancer peptide prepared by use of the method disclosed by the invention is not only high in anticancer property, but also small in toxicity and safer to the human body.
Owner:贵州源熙生物研发有限公司
Preparation and anti-tumor effect of RGD/KLA integrated lipopeptide
The invention relates to preparation of anti-cancer lipopeptide C8H15O-Lys-Ala-Lu-Lys-Ala-Lu-Lys-Ala-Lu-Lys-Ala-Lu-Lys-Asp-Gly-Arg and application of the anti-cancer lipopeptide C8H15O-Lys-Ala-Lu-Lys-Asp-Gly-Arg in anti-tumor treatment, and belongs to the field of biological medicine. The anti-cancer lipopeptides are prepared based on key biological characteristics (positive charges, alpha-helical structure and amphipathy) of membrane lysis peptides. The invention provides a solid-phase synthesis method of the anticancer lipopeptide. The anti-cancer lipopeptide has the characteristics of low hemolytic activity and good serum stability, can effectively overcome the defect of high hemolytic toxicity of most anti-cancer peptides, and solves the problem of poor in-vivo stability of peptide drugs. An in-vitro anti-cancer experiment and an in-vivo anti-tumor experiment prove that the anti-cancer lipopeptide has a good anti-tumor effect and a good application prospect.
Owner:BINZHOU MEDICAL COLLEGE
Design of new anti-cancer peptides and application of anti-cancer peptides in preventing tumors
Two anti-cancer peptides with anti-tumor effects have the following amino acid sequences. Experiments show that SZG3 and SZG5 have very good selectivity and inhibitory activities on tumor cells. The present invention discloses the amino acid sequences and antitumor activities of the two anti-cancer peptides. The amino acid sequence of the SZG3 is MAMVGTRHHHHH and the amino acid sequence of the SZG5 is MWAIVLLRHHHHH.
Owner:孙治刚
A method for isolating prostate cancer PC-3 anticancer peptide and its anticancer peptide by using the heat reactant of crucian carp protein antibacterial peptide liquid
ActiveCN103665103BImprove fishy smellPromote absorptionTetrapeptide ingredientsPeptide preparation methodsChemical synthesisMedicine
The invention relates to a method for separating out a prostatic cancer (PC)-3 anticancer peptide by utilizing a thermal reactant of setipinna taty protein antibacterial peptide liquid and an anticancer peptide obtained by using the method. The method is characterized by comprising the following steps of (1), preparing setipinna taty protein antibacterial peptide liquid, regulating the pH value of the setipinna taty protein antibacterial peptide liquid to 5.0-7.0; (2), thermally treating the setipinna taty protein antibacterial peptide liquid, heating for 30 minutes-60 minutes in a sterilization pot of 100 DEG C-121 DEG C to prepare the thermal reactant of setipinna taty protein antibacterial peptide liquid; and (3), separating out the anticancer peptide from the thermal reactant of the setipinna taty protein antibacterial peptide liquid. Compared with the prior art, the method disclosed by the invention has advantages that setipinna taty protein antibacterial peptide liquid is taken as a starting substrate, and two-step gel separation is carried out, so that the prostatic cancer (PC)-3 anticancer peptide separated from the thermal reactant of the setipinna taty protein antibacterial peptide liquid has purity larger than 94%, is small in molecular weight and is easily absorbed by human body without easily causing anaphylactic reaction. The chemically synthesized peptide of the anticancer peptide shows dose-dependent characteristic for proliferation inhibition of the prostatic cancer (PC)-3 anticancer peptide, and has very obvious apoptosis-inducing effect on PC-3 tumor cells, and can block cell division in a period S.
Owner:ZHEJIANG OCEAN UNIV
Method for separating out prostatic cancer (PC)-3 anticancer peptide by utilizing thermal reactant of setipinna taty antibacterial peptide liquid and anticancer peptide obtained by using method
ActiveCN103665103AImprove fishy smellPromote absorptionTetrapeptide ingredientsPeptide preparation methodsChemical synthesisCell division
The invention relates to a method for separating out a prostatic cancer (PC)-3 anticancer peptide by utilizing a thermal reactant of setipinna taty protein antibacterial peptide liquid and an anticancer peptide obtained by using the method. The method is characterized by comprising the following steps of (1), preparing setipinna taty protein antibacterial peptide liquid, regulating the pH value of the setipinna taty protein antibacterial peptide liquid to 5.0-7.0; (2), thermally treating the setipinna taty protein antibacterial peptide liquid, heating for 30 minutes-60 minutes in a sterilization pot of 100 DEG C-121 DEG C to prepare the thermal reactant of setipinna taty protein antibacterial peptide liquid; and (3), separating out the anticancer peptide from the thermal reactant of the setipinna taty protein antibacterial peptide liquid. Compared with the prior art, the method disclosed by the invention has advantages that setipinna taty protein antibacterial peptide liquid is taken as a starting substrate, and two-step gel separation is carried out, so that the prostatic cancer (PC)-3 anticancer peptide separated from the thermal reactant of the setipinna taty protein antibacterial peptide liquid has purity larger than 94%, is small in molecular weight and is easily absorbed by human body without easily causing anaphylactic reaction. The chemically synthesized peptide of the anticancer peptide shows dose-dependent characteristic for proliferation inhibition of the prostatic cancer (PC)-3 anticancer peptide, and has very obvious apoptosis-inducing effect on PC-3 tumor cells, and can block cell division in a period S.
Owner:ZHEJIANG OCEAN UNIV
Anticancer peptides
PendingCN111511761APolypeptide with localisation/targeting motifPeptide/protein ingredientsPharmaceutical SubstancesPharmacology
The present invention provides a peptide of formula (I) or a pharmaceutical salt thereof, as well as fusion peptides and pharmaceutical compositions comprising it; or, alternatively, the peptide or pharmaceutical salt thereof is one which has an amino acid sequence with an identity from 85% to 95% with respect to sequence SEQ ID NO: 25, 26, 27 or 28. The peptides of the invention show anticancer activity.
Owner:IDP DISCOVERY PHARMA SL
Anticancer peptide DMS-PS1 of South America frog and application thereof
ActiveCN114835791AInhibition of value addedInduce apoptosisPeptide/protein ingredientsGenetic engineeringProstate cancer cellAnticarcinogenic Effect
The invention discloses a South America frog anti-cancer peptide DMS-PS1 and application thereof, the South America frog anti-cancer peptide DMS-PS1 can be used in the field of anti-cancer drugs and health care products and preparation, the novel natural anti-cancer peptide DMS-PS1 is separated from frog skin secretions by taking South America frog Phy l lomeduasauvagi as a material, and the novel natural anti-cancer peptide DMS-PS1 can be used for preparing anti-cancer drugs and health care products. The open reading frame of the polypeptide is composed of 76 amino acids, contains highly conservative signal peptide composed of 22 amino acid residues, is rich in aspartic acid, glutamic acid and other acidic amino acids, has a molecular weight of 2931.43 Daltons, contains amidation modification at the C-terminal, is an amphiphilic cationic peptide with an alpha-helical structure, and has a molecular weight of 2931.43 Daltons. The natural anti-cancer peptide DMS-PS1 disclosed by the invention shows spectral anti-cancer activity and shows certain killing selectivity to prostate cancer cells, and research finds that the natural anti-cancer peptide DMS-PS1 has an anti-cancer effect by inducing PC-3 cell apoptosis, so that a potential medicine is provided for cancer treatment.
Owner:WENZHOU UNIVERSITY
Anticancer peptide compositions
InactiveUS20050239703A1Reduce the burden onTumor burdenPeptide/protein ingredientsDepsipeptidesAbnormal tissue growthAngiogenesis growth factor
The invention provides compositions and methods for inhibiting angiogenesis associated with tumors and reducing tumor growth.
Owner:TRANXENOGEN
Anticancer peptide
A polypeptide and methods of using the polypeptide for treating malignancy by administering to a subject a composition of the polypeptide. Pharmaceutical compositions of the polypeptide.
Owner:THOMPSON EDWARD BRADBRIDGE +2
Anticancer peptides
ActiveUS11440939B2Peptide/protein ingredientsAntibody mimetics/scaffoldsPeptide sequenceMedicinal chemistry
The present invention provides a peptide of formula (I) or a pharmaceutical salt thereof wherein “m”, “n”, “p”, and “q” represent integers and are selected from 0 and 1; and “r” is comprised from 1 to 10; a linker biradical of formula (II), which is connecting an alpha carbon atom of an amino acid located at position “i” in the peptide sequence of formula (I) with an alpha carbon atom of an amino acid located at position “i+4” or “i+7” in the peptide sequence of formula (I); a C-terminal end corresponding to —C(O)R4; and a N-terminal end corresponding to —NHR5. The peptides of the invention show anticancer activity and an appropriate half-life and stability. Formula (I).
Owner:IDP DISCOVERY PHARMA SL
Preparation of anti-cancer lipopeptide and application of anti-cancer lipopeptide in anti-tumor treatment
The invention relates to a preparation method of an anti-cancer lipopeptide C8H15O-Asp-Ser-Asp-Val-Trp-Trp-Gly-Gly-Arg-Arg-Leu-Leu-Arg-Arg-Leu-Arg-Arg-Leu, and an application of the anti-cancer lipopeptide C8H15O-Asp-Ser-Asp-Val-Trp-Trp-Gly-Arg-Arg-Leu in anti-tumor treatment, and belongs to the field of biological medicines. The anti-cancer lipopeptides are prepared based on key biological characteristics (positive charges, alpha-helical structure and amphipathy) of membrane lysis peptides. The invention provides a solid-phase synthesis method of the anticancer lipopeptide. The anti-cancer lipopeptide has the characteristics of small hydrophobic torque, low hemolytic activity and good serum stability, can effectively overcome the defect of high hemolytic toxicity of most anti-cancer peptides, and solves the problem of poor in-vivo stability of peptide drugs. An in-vitro anti-cancer experiment and an in-vivo anti-tumor experiment prove that the anti-cancer lipopeptide has a good anti-tumor effect and a good application prospect.
Owner:BINZHOU MEDICAL COLLEGE
A kind of antibacterial fusion peptide and its preparation method and application
ActiveCN108610428BEasy accessImprove anti-cancer effectAntibacterial agentsPeptide/protein ingredientsAntimicrobial actionKanamycin
Owner:西安华企众信科技发展有限公司
Anticancer peptides
ActiveUS20210230226A1Peptide/protein ingredientsAntibody mimetics/scaffoldsPeptide sequenceMedicinal chemistry
The present invention provides a peptide of formula (I) or a pharmaceutical salt thereof wherein “m”, “n”, “p”, and “q” represent integers and are selected from 0 and 1; and “r” is comprised from 1 to 10; a linker biradical of formula (II), which is connecting an alpha carbon atom of an amino acid located at position “i” in the peptide sequence of formula (I) with an alpha carbon atom of an amino acid located at position“i+4” or “i+7” in the peptide sequence of formula (I); a C-terminal end corresponding to —C(O)R4; and a N-terminal end corresponding to —NHR5. The peptides of the invention show anticancer activity and an appropriate half-life and stability. Formula (I).
Owner:IDP DISCOVERY PHARMA SL
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