43 results about "Benzoic hydrazide" patented technology

The invention discloses a synthetic technology of azelastine hydrochloride, which is characterized in that acylhydrazone is formed by N-Methylhexahydroazepin-4-one hydrochloride and benzoyl hydrazine and then is reduced with potassium borohydride, and finally is condensed with 2-(para chlorobenzene acetyl) benzoic acid into 4-( chlorine benzyl)-2-piperazidine-1- methyl-1H-azelastine-4- radical)-1-(2H)-phthalazine hydrochloride. The synthetic technology has the advantages of simple process and higher yield.

The invention discloses a chlorine fastness improver, and a preparation method and an application thereof. The chlorine fastness improver comprises, by mass, 1-5% of polyacrylate, 5-48% of a hydrazide derivative, 0.5-6% of a dispersant, and the balance of water. The hydrazide derivative concretely is one or more of octanedioic dihydrazide, azelaic dihydrazide, sebacic dihydrazide, dodecanedioic dihydrazide, isonicotinoylhydrazine, 1,2-diisonicotinic acid hydrazide, 1,2-dimethyl-1,2-dibenzoylhydrazine and isophthalic dihydrazide. The preparation method of the chlorine fastness improver is simple, and the chlorine fastness improver makes chinlon and spandex swimming suit dyed fabrics have the advantages of effectively improved chlorine fastness, small color change, good handle, good chlorine fastness and good water wash resistance.

The invention provides an anion receptor based on 5-nitrofuran formyl hydrazone and phenolic hydroxyl. The anion receptor is obtained by mixing 2, 6-dimethylacyl-4-chlorophenol and 5-(4-nitro)-phenyl-2-benzoyl diazanyl furan according to certain proportion, stirring and refluxing the mixture for 3 to 8 hours at a temperature of between 70 and 100 DEG C by using anhydrous ethanol as a solvent and p-toluene sulfonic acid as a catalyst, distilling out most of the solvent through reducing the pressure, performing suction filtration after cooling, and performing recrystalization on the solid product by using DMSO-EtOH. The anion receptor has color comparison recognizing ability on fluorion, acetic acid radical and phosphoric acid dihydrogen radical in a DMSO solution. The anion receptor is dissolved in DMF to be prepared into 0.5 to 2.0 percent of solution which is cooled to room temperature to be prepare into stable anion receptor organic gel used for performing colorimetric detection on the fluorion, and the acetic acid radical and phosphoric acid dihydrogen radical ions in the DMSO solution. The anion receptor has the advantages of convenience for carrying, convenient use, high detection sensitivity and the like.

The invention provides a nitrogen-oxynickel complex catalytic system for polymerization of norbornene and its derivative, its preparation method and application. Said catalytic system for polymerization is formed from main catalyst nitrogen-oxynickel complex-bis (4,5-diazafluorene-9-ketone substituted benzoyl hydrazone) II nickel dihydrate (A) or brominated bis (2-pyridylaldehyde substituted benzoyl hydrazone) II nidal (B) and auxiliary catalyst methylaluminoxane. The preparation method of main catalyst nitrogen-oxynickel complex includes the following steps: firstly, using substituted benzoyl hydrazine and 4,5-diazafluorene-9-ketone or 2-pyridylaldehyde to prepare N,O bidenate, then making the the ligand and tetrahydrate nickel acetate or 1,2-dimethoxyethane nickel bromide product reaction so as to respectively obtain the main catalyst (A) or (B). Said invention process is simple, its raw materials are easily available, the use level, methylaluminoxane is low, and the yield rate of polynorbornene and its derative can be up to 20-100%.

The invention discloses a near-infrared molecular probe based on malonaldehyde response, a preparation method and application of the near-infrared molecular probe based on malonaldehyde response, and the near-infrared molecular probe based on malonaldehyde response takes xanthene-derived organic dye as a parent structure and contains an electron withdrawing group nitryl and a malonaldehyde reaction site benzoyl hydrazine group. The molecular conjugation degree is changed through the nucleophilic reaction of the hydrazine group of the o-nitrobenzoyl hydrazine and the MDA, so that the change of absorbance is caused, and the MDA detection is realized. The invention provides application of the molecular probe, a nano-probe NPs for MDA detection and imaging is prepared, the nano-probe takes near-infrared absorption CS-R and amphiphilic polymer DSPE-PEG2000 as main bodies, and a conjugated system of the CS-R in the nano-probe is changed through an addition reaction of MDA, so that fluorescence imaging is realized, detection and imaging with high sensitivity and good specificity on MDA are realized, and the problems of short wavelength and poor penetration depth of a conventional malondialdehyde probe are greatly improved.

The invention relates to detection of copper ions and particularly relates to a pyrene derivative and a synthetic method and an application thereof. The pyrene derivative is as shown in a formula I. Abenzoyl hydrazine derivative P obtained by means of an effective synthetic means shows relatively good selectivity on copper ions. Based on an optimized experimental condition, copper ions can be detected. The formula is as shown in the description.

The invention relates to a 1, 3, 4-oxadiazole neuraminidase inhibitor as well as a preparation method and an application thereof. The inhibitor has a structure as shown in a formula (I). The preparation method specifically comprises the following steps: (1) reacting aniline, chloroacetyl chloride and triethylamine, and performing post-treatment to obtain an intermediate as shown in a formula (II); (2) performing reaction on benzoyl hydrazine, carbon disulfide and potassium hydroxide, and performing post-treatment to obtain an intermediate as shown in a formula (III); and (3) dissolving the intermediate shown in the formula (II) and the intermediate shown in the formula (III) in an organic solvent, reacting, and performing post-treatment to obtain the inhibitor shown in the formula (I). Compared with the prior art, the compound is novel in structure, and experiments show that the compound has good neuraminidase inhibitory activity and can be used for preparing drugs for inhibiting neuraminidase activity.

The invention discloses a benzoyl hydrazine allosteric inhibitor for D-3-phosphoglycerate dehydrogenase and applications of the benzoyl hydrazine allosteric inhibitor, wherein the structure of the benzoyl hydrazine allosteric inhibitor is shown as the formula I, R1, R2, R3, R4, R5, R6 and R7 are the same or different, and respectively represent hydrogen, halogen, nitryl, hydroxyl, amino or substituted amino, alkyl, alkoxy, and benzyloxy or halogen substituted alkyl independently, or the adjacent substituent groups can form a ring. The in-vitro enzymatic activity testing, cell viability testing and mouse heterotransplantation model experiment prove that the compound can specifically inhibit the activity of D-3-phosphoglycerate dehydrogenase, and the growth of cancer cells is delayed by reducing the overexpression of D-3-phosphoglycerate dehydrogenase in the cancer cells. The compound can be used for treating, preventing or inhibiting the tumor diseases including breast cancer, colon cancer, melanoma and non-small cell lung cancer when used independently or in combination with other anti-cancer drugs. The formula I is shown in the description.

The invention belongs to the technical field of metal organic framework materials, and particularly relates to an MOFs fluorescent probe for detecting aromatic amine VOC as well as a preparation method and application of the MOFs fluorescent probe. The MOFs fluorescent probe is an infinite network structure material formed by connecting a cadmium salt and an organic ligand in a coordination bond manner, and the cadmium salt comprises cadmium chloride or cadmium chloride hydrate; the organic ligand comprises an N-(2-hydroxy-3-methoxybenzylidene)-4-(imidazolyl) benzoyl hydrazine ligand; the MOFs fluorescent probe has the advantages that the fluorescent effect of the MOFs fluorescent probe on aromatic amine VOC is obviously enhanced, the MOFs fluorescent probe not only has fluorescence enhanced detection on liquid aromatic amine, but also has detection effect on gaseous aromatic amine, and as a porous multifunctional material, the MOFs fluorescent probe shows completely reversible behavior on adsorption of aniline steam at room temperature, the preparation method is simple, the cost is low, the effect is good, and the material is a promising aniline vapor light-emitting sensor and adsorbent material, and has high practical application value.

The invention provides a modified PGA material with long shelf life and a preparation method thereof. The modified PGA material is prepared from, by weight, 0.2-0.5 part of a chain extender, 70-80 parts of polyglycolic acid, 15-30 parts of filler and 1-5 parts of an anti-blocking agent, wherein the molecular weight of the polyglycolic acid is 100,000-300,000 g / mol, and the melting point of the polyglycolic acid is 200-220 DEG C; the anti-blocking agent is nano silicon dioxide with the specific surface area of less than 200 m<2> / g, the pH value is 3.8-4.3, and the water content is lower than 2%; and the chain extender is a mixture of an epoxy chain extender and sebacic acid dibenzoyl hydrazine. According to the invention, the specific polyglycolic acid is modified by adopting the chain extender and the anti-blocking agent, so that the modified PGA material has a relatively long shelf life; the tensile property and the stiffness are better; the shelf life can reach up to 6 months; the tensile strength is 31 to 33 MPa; the elongation at break is 9.5 to 10 percent; and the stiffness is 1.5 to 2 N.m.

The invention discloses a graphene metal anticorrosive paint for primary equipment in coastal areas and a preparation method thereof. The paint comprises the following components in parts by weight: 50-100 parts of polyvinylidene fluoride, 0.1-1 part of benzoyl hydrazine modified graphene oxide powder, 3-7 parts of a dispersing agent, 2-6 parts of a leveling agent, 5-15 parts of a curing agent, 10-20 parts of a diluent, 1-10 parts of a functional filler and 15-20 parts of a mixed solvent. The preparation method of the benzoyl hydrazine modified graphene oxide powder comprises the following steps: (1) dispersing graphene oxide in a solvent, adding benzoyl hydrazine according to a molar ratio of graphene oxide to benzoyl hydrazine of 1: (1-5), carrying out an ultrasonic treatment and separation to obtain a benzoyl hydrazine modified graphene oxide crude product; and (2) purifying the modified graphene oxide crude product obtained in the step (1) to obtain benzoyl hydrazine modified graphene oxide. Modified graphene oxide is more easily adsorbed to the metal surface, the adhesiveness of the paint is improved, diffusion of water molecules and corrosive ions can be effectively blocked,and the corrosion prevention effect is improved.

A method and a device for producing and storing electrical energy using iron complexes, using an iron +III molecular complex as well as a photoreduced iron +II complex, both complexed chemically by a ligand of the benzoic hydrazide type.

The invention provides a chromone-containing benzoyl hydrazone compound with an inhibiting effect on growth of synechocystis PCC6803 and a preparation method thereof. The molecular structure of the compound is shown as a formula I, wherein R1 is selected from hydrogen, halogen, nitro, hydroxyl, carboxyl and C1-C4 alkyl; R2 is selected from hydrogen, bromine, hydroxyl or nitro; R3 is selected fromhydrogen or hydroxyl; R4 is selected from hydrogen, halogen, nitro, trifluoromethyl or hydroxyl; and R5 is selected from hydrogen or hydroxyl. The invention further provides a preparation method of the compound. According to the preparation method, benzoyl hydrazine or a substituent thereof reacts with 3-formyl chromone or a substituent thereof in an ethanol environment containing acetic acid to generate the compound. The compound has a good effect on inhibiting the growth of synechocystis PCC6803, the EC50 value is within a range of 0.8-29.8 [mu]M, and the compound can be used for preparing related algistat products.

The invention relates to the technical field of synthesis of raw material medicines, and particularly discloses a preparation method of azelastine hydrochloride. The method comprises the following steps: condensing benzoyl hydrazine and 1-methylhexahydroazepine-4-one serving as raw materials, reducing with sodium borohydride, and reacting to obtain a compound 1; preparing a solid intermediate compound 2 from the compound 1 and organic binary weak acid; hydrolyzing the compound 2, and cyclizing with a compound 3 to form a compound 4; and salifying the compound 4 by hydrochloric acid, and separating water by toluene to obtain a compound 5, namely azelastine hydrochloride. The intermediate compound 2 prepared by the invention is a solid, the stability of the intermediate compound 2 is greatly improved compared with that of hydrochloride obtained in other literatures, the intermediate compound 2 is free of hygroscopicity, the purity can reach 99% or above, the quality risk of subsequent bulk drugs can be greatly reduced, and the process production operation space is larger; and the obtained azelastine hydrochloride does not contain water and meets related quality standards, the yield is increased to 80% or above compared with other literatures, and the purity can reach 99% or above.

The invention discloses a binuclear cadmium complex with anticancer activity as well as a preparation method and application thereof. The binuclear cadmium complex is an infinite network structure material formed by connecting cadmium salt and an organic ligand in a coordination bond manner, the binuclear cadmium complex is di-[4-fluoro-N '-(2-hydroxyl-3-methoxybenzylidene) benzoyl hydrazine], or di-[N'-(2-hydroxyl-3-methoxybenzylidene)-4-(1, 2, 2-triphenylvinyl) benzoyl hydrazine], or di-[N '-(2-hydroxyl-3-methoxybenzylidene)-4-(1, 2, 2-triphenylvinyl) benzoyl hydrazine], or di-[N'-(2-hydroxyl-3-methoxybenzylidene)-4-(1, 2, 2-triphenylvinyl) benzoyl hydrazine]. The binuclear cadmium complex disclosed by the invention takes a binuclear planar cadmium unit as a metal ligand, is assembled into a metal organic framework with a stable planar structure, has relatively strong tumor cell apoptosis inducing capability on human breast cancer cells and human lung cancer cells, and also has remarkable tumor cell resisting activity. Therefore, the binuclear cadmium complex provided by the invention is a promising material for developing novel anti-tumor drugs, and has a relatively high application value in developing the anti-tumor drugs.

The invention discloses a compound pesticide composition, which contains N-benzoyl-N'-tert-butyl benzhydrazide and epimethylamino-4''-deoxyavermectin b1 benzoate. The invention further discloses application of the composite pesticide composition on prevention and treatment of crop lepidoptera pests comprising cnaphalocrocis medinalis, stem borer, cotton bollworm, plutella xylostella, beet armyworm and the like, and a compound pesticide based on the compound pesticide composition. The compound pesticide composition provided by the invention has a remarkable effect on the prevention and treatment of the lepidoptera pests, in particular to the cnaphalocrocis medinalis, and has the characteristics of being low in toxicity, residues and cost, and friendly to environment, so that the compound pesticide composition has broad prospects, great social and economic benefits and direct economic benefits.

The invention relates to detection of copper ions and particularly relates to a pyrene derivative and a synthetic method and an application thereof. The pyrene derivative is as shown in a formula I. Abenzoyl hydrazine derivative P obtained by means of an effective synthetic means shows relatively good selectivity on copper ions. Based on an optimized experimental condition, copper ions can be detected. The formula is as shown in the description.

The invention discloses a synthetic method of 2-(5-aryl-1,3,4-oxadiazol-2-yl) aniline compound, the method comprises the following steps: electrolyte, substituted isatin, The substituted benzoylhydrazide, solvent, base, and electrode are respectively added to the electrolytic cell without separation, and the electricity is stirred to react; the solution after the reaction is separated and purified to obtain 2-(5-aryl-1,3,4-oxadi Azol-2-yl) aniline compounds, the preparation process does not require the use of metals and chemical oxidants, the reaction time is short, and the preparation process is green and environmentally friendly.

The invention discloses a graphene modified polypropylene composite material and a preparation method thereof. The graphene modified polypropylene composite material is mainly prepared from the following raw materials in parts by weight: 100 parts of polypropylene, 5-6 parts of graphene, 5-6 parts of calcium sulfate whiskers, 10-20 parts of a styrene-butadiene segmented copolymer, 10-20 parts of an ethylene-vinyl acetate copolymer, 0.1-0.3 part of divinyl benzene, 0.5-2 parts of benzoyl hydrazine, and 0.5-1.5 parts of a titanate coupling agent. The invention further discloses the preparation method of the graphene modified polypropylene composite material. The graphene modified polypropylene composite material disclosed by the invention is particularly suitable for manufacturing various electric appliance shells with high requirements on high strength due to high crystallization rate, high impact strength and good toughness.

The invention discloses a synthesis method of a 2-(5-aryl-1,3,4-oxadiazol-2-yl)aniline compound. The method comprises the following steps: respectively adding an electrolyte, substituted isatin, substituted benzoyl hydrazine, a solvent, an alkali and an electrode into a non-separated electrolytic cell, and carrying out electrifying and stirring for a reaction; and subjecting a solution obtained after the reaction to separating and purifying so as to obtain the 2-(5-aryl-1,3,4-oxadiazol-2-yl)aniline compound. According to the method, no metal or chemical oxidant is needed in the preparation process; reaction time is short; and the preparation process is green and environmentally friendly.

The invention provides a novel acylhydrazone molecular switch and synthesis thereof and a method for photoinduced slow release of a drug. The molecular switch is formed by condensation of 2-methoxynaphthaldehyde and benzoyl hydrazine. As both sides adjacent to an imine group of hydrazide have groups with high steric hindrance, an E-isomer is easily converted into a Z-isomer under illumination, andthe E-Z isomer conversion efficiency is up to 99 percent, and the quantum yield is up to 89 percent. After being prepared in an amphiphilic molecular switch, the hydrazide can be self-assembled in water to form nano-vesicles, and the vesicles can also undergo E-Z isomer conversion with high conversion rate under the illumination. The vesicles can carry an anticancer drug procarbazine in an inclusion manner, so that the solubility of the drug in water is increased by 225 times. The included procarbazine is released from the vesicles under the illumination.

The invention relates to a method and a device for producing and storing electrical energy using iron complexes, using a molecular complex of iron + III as well as a photoreduced iron +II complex, both complexed chemically by a ligand of the benzoic hydrazide type.

The invention belongs to the field of medical chemistry, and particularly relates to a preparation method of a 2-amino-1, 3, 4-oxadiazole compound and the compound prepared by the preparation method. According to the method, the 1, 3, 4-oxadiazole compound is prepared by taking the isothiocyanate compound and the benzoyl hydrazine compound as raw materials and taking the mild, cheap and easily available potassium hydrogen sulfate as the catalyst, so that not only is the use of harmful reagents with relatively strong corrosivity such as sulfuric acid avoided, but also the yield can be up to 85%, and the method is convenient in post-treatment and suitable for industrial production.

Myricetin which is obtained by extraction, separation and purification from Ampelopsis grossedentata (Hand.-Mazz.) W.T. Wang is adopted as a lead compound, and is subjected to a condensation reactionwith amino-containing compounds such as phenylhydrazine, benzoyl hydrazine, phenylaminourea, phenylthiosemicarbazide, phenylacetylhydrazine, phenoxyacethydrazide and phenylaminoacethydrazide to obtainmyricetin derivatives. Enzymology and cell tests prove that the myricetin derivatives have a relatively strong effect of inhibiting acetylcholin esterase, so that the effect of preventing and treating Alzheimer's disease is achieved. Further research shows that the activity of most myricetin derivatives is higher than that of the lead compound.

The invention relates to the field of organic functional new material chemicals, and discloses a new process technology for preparing m / p-phenylenediamine through rearrangement reaction of m / p-phthalic acid bishydrazide or derivatives thereof for the first time. The m-phenylenediamine (p-phenylenediamine) is a widely-used bulk key fine chemical in the related fields of known dyes, pigments, aramid fibers, medicines and pesticides, building auxiliary materials and the like, and the production process innovation technology of the m-phenylenediamine (p-phenylenediamine) is widely concerned.

The invention relates to a flavonoid tankyrase-2 inhibitor and a preparation method and application thereof. The flavonoid tankyrase-2 inhibitor has a structure as shown in formula I. The inhibitor adopts 4-oxo-4H-1-benzopyran-2-carboxylic acid and an aniline derivative or a benzoyl hydrazine derivative as initial raw materials, adopts a uronium salt as a condensing agent, and under the condition of adding alkali, condensation reaction is conducted in an organic solvent to obtain the inhibitor. Compared with the prior art, the preparation method disclosed by the invention is simple, and the synthesized compound is novel in structure and has better activity of inhibiting tankyrase 2 and better selectivity.

The invention discloses a thread locking anaerobic adhesive and a preparation method thereof, and belongs to the technical field of adhesive preparation. The invention aims to solve the problems thatthe anaerobic adhesive is slowly cured at room temperature and is difficult to cure at low temperature or when an inert material is bonded. The adhesive comprises an anaerobic curing adhesive solutionand an accelerating base agent, wherein the anaerobic curing adhesive solution is mainly prepared from the following components in parts by weight: 100 parts of an anaerobic acrylate monomer, 0.01-10parts of an accelerant, 0.01-10 parts of an auxiliary accelerant and 1-10 parts of an initiator; wherein the promoting base agent is mainly prepared from the following components in parts by weight:0.01 to 5 parts of ferrocene compound, 0 to 5 parts of benzoyl hydrazine compound and 100 parts of volatile solvent. The adhesive is used for locking the anaerobic adhesive through the threads.

The invention discloses a graphene oxide modified polypropylene composite material and a preparation method thereof. The graphene oxide modified polypropylene composite material is prepared from, by weight, 100 parts of polypropylene, 5-6 parts of graphene oxide, 5-6 parts of calcium sulfate whiskers, 10-20 parts of styrene-butadiene segmented copolymer, 10-20 parts of ethylene-vinyl acetate copolymer, 0.1-0.3 part of divinyl benzene, 0.5-2 parts of benzoyl hydrazine, and 0.5-parts of a titanate coupling agent. The invention further discloses a preparation method of the graphene oxide modifiedpolypropylene composite material. The graphene oxide modified polypropylene composite material is high in crystallization rate, high in impact strength and good in toughness, so that the graphene oxide modified polypropylene composite material is particularly suitable for manufacturing various electric appliance shells requiring high strength.