18 results about "Benzoic hydrazide" patented technology

The present invention relates to a class of (R)-2-aryl-4,5-dihydrothiazole-4-carboxylic acid derivatives containing dihydrazide having fungicidal activity as shown in general formula (I), as well as preparation methods and applications thereof. A pesticide molecule design method of splicing active fragments is used to connect differently substituted (R)-2-aryl-4,5-dihydrothiazole-4-carboxylic acids with differently substituted benzoylhydrazides, wherein R1, R2, R3, R4, R5, R6, R7, R8, R9 and R 10 As defined in the specification. The technical effect of the present invention is: a class of (R)-2-aryl-4,5-dihydrothiazole-4-carboxylic acid derivatives containing dihydrazide with broad-spectrum fungicidal activity has been discovered, which is a fungicide with broad application prospects.

This application relates to a MALDI reactive matrix, 5-methoxy-2-hydroxybenzoyl hydrazine, for the analysis of reducing sugars, belonging to the field of sugar biochemical analysis technology. This application provides the application of 5-methoxy-2-hydroxybenzoyl hydrazine as a MALDI reactive matrix in combination with 2,5-dihydroxybenzoic acid in the analysis of reducing sugars. Specifically, 5-methoxy-2-hydroxybenzoyl hydrazine is the reactive matrix, possessing a hydrazine reactive group that can react with the hemiacetal terminus of reducing sugars. 2,5-dihydroxybenzoic acid acts as a catalyst, significantly promoting the efficient reaction between 5-methoxy-2-hydroxybenzoyl hydrazine and reducing sugars. The 5-methoxy-2-hydroxybenzoyl hydrazine / 2,5-dihydroxybenzoic acid composite matrix provided in this application can form a uniform co-crystallization with reducing sugars, exhibiting good signal reproducibility (RSD < 10%) and good linearity in the range of 0.2~20 pmol / μL (R0). 2 > 0.999).

The present invention belongs to the technical field of preparation of oxadiazole derivatives. The present invention provides a method for preparing 2-amino-1,3,4-oxadiazole derivatives by electrocatalysis, comprising the following steps: adding 0.2mmol of benzoylhydrazide compounds, 0.4mmol of tetrabutylammonium iodide, 0.4mmol of 1,4-diazabicyclo[2.2.2]octane, 0.4mmol of sodium bicarbonate, and 6mL of acetonitrile to an electrolytic cell; then adding 0.3mmol of phenyl isothiocyanate compounds dropwise; reacting under a DC constant current between an electrode anode and an electrode cathode. The present invention adopts electrocatalysis with benzoylhydrazide and phenyl isothiocyanate as reaction substrates, acetonitrile and other cheap and less toxic reagents as solvents, and passing current to replace the oxidant in conventional reactions, thereby synthesizing oxadiazole compounds under mild and green conditions.

The invention provides an anti-neuroinflammation medicine as well as a preparation method and application thereof. The anti-neuroinflammation medicine comprises an active component and lipidosome, the active component is an inhibitor 4-aminobenzoyl hydrazine of myeloperoxidase; the liposome is prepared from phospholipid, cholesterol and distearoyl phosphatidyl ethanolamine-thioketal-polyethylene glycol; the method comprises the following steps: weighing lipidosome and 4-aminobenzoyl hydrazine, dissolving, and carrying out rotary evaporation to obtain a lipid membrane; adding a phosphate buffer solution into the lipid membrane, stirring in a water bath, performing ultrasonic treatment, filtering, centrifuging and purifying to obtain the medicine, according to the active oxygen response-based liposome delivery system disclosed by the invention, 4-aminobenzoyl hydrazine is encapsulated in liposome to form a drug, and after the drug enters a brain inflammation microenvironment area of the Alzheimer's disease, the active oxygen can break a thioketal bond, so that local release of 4-aminobenzoyl hydrazine is triggered, targeted inhibition of myeloperoxidase is realized, and the drug delivery effect is improved. The oxidative stress level is reduced, the neuroinflammation is relieved, and the cognitive impairment is effectively improved.

The invention relates to a separation and purification method and application of an azastine hydrochloride benzoyl hydrazone intermediate, and the separation and purification method comprises the following steps: mixing methylhexahydroazepine-4-one hydrochloride, sodium bicarbonate and benzoyl hydrazine, reacting, carrying out post-treatment, and recrystallizing to obtain the azastine hydrochloride benzoyl hydrazone intermediate. According to the method, a benzoyl hydrazone intermediate separation and purification process is provided, quality control points are increased, and the quality risk of a final product is reduced.

The invention relates to the technical field of degradable materials, in particular to a degradable polyester resin material and a preparation method thereof. The polyester resin material is mainly prepared from PBAT, PBS, a chitosan stearoyl graft, a chitosan stearoyl catechol double graft, sebacyl dibenzoyl hydrazine, a chain extender containing an epoxy functional group, anhydrous zinc acetate and an antioxidant according to a specific proportion, and a multi-stage reaction extrusion and special heat treatment process is adopted. Through grafting and introduction of a reversible coordination network, the thermal deformation temperature of the polyester material is greatly improved, a heat-sealing window is remarkably widened, and collaborative optimization of mechanical properties and degradation properties is realized. The obtained resin material has excellent film-forming property, thermal and mechanical properties and environmental friendliness, and is suitable for the fields of green packaging and the like.

The application provides an A,A'-dihydroxynaphthaldehyde hydrazone functionalized conjugated pillar[5]arene and a synthesis method thereof. First, a di-m-benzoic acid methyl ester functionalized conjugated pillar[5]arene and hydrazine hydrate are used as substrates to react in anhydrous ethanol solvent to obtain a di-m-benzoic acid hydrazine functionalized conjugated pillar[5]arene; then the di-m-benzoic acid hydrazine functionalized conjugated pillar[5]arene and 2-hydroxy-1-naphthaldehyde are used as substrates to react in anhydrous methanol to obtain the A,A'-dihydroxynaphthaldehyde hydrazone functionalized conjugated pillar[5]arene HGP5. The sensor molecule HGP5 in the application can detect Arg in a "colorimetric fluorescence" dual-channel mode, and can also detect Al 3+ in a super-sensitive mode under fluorescence. In addition, the chemical sensor has potential application in cell imaging, and can detect Al 3+ and Arg in cells. The application provides a new idea for developing a novel supramolecular fluorescent material for detecting Arg and Al 3+ in an aqueous solution.

The invention provides a preparation method of an isoxazole-oxadiazole compound, which comprises the following steps: reacting 4-chloro-2-fluoro-3-vinylbenzoic acid with tert-butyloxycarboryl hydrazine in the presence of a condensing agent and a catalyst, then removing a protecting group under an acidic condition to obtain an intermediate 4-chloro-2-fluoro-3-vinylbenzoyl hydrazine, and then reacting with N, N-dimethylformamide to obtain the isoxazole-oxadiazole compound. The method comprises the following steps: cyclizing N, N '-carbonyldiimidazole in the presence of alkali, carrying out an O-alkylation reaction with an alkylation reagent R1-X in the presence of alkali, and carrying out an olefin dihydroxylation-sodium periodate oxidation cleavage reaction in the presence of an oxidant and a catalyst; reacting with hydroxylamine in the presence of alkali, and finally carrying out 1, 3-dipolar cycloaddition reaction with an acrylate compound in the presence of alkali and an oxidizing agent. The method is carried out at room temperature, has the advantages of mild conditions, simplicity in operation and the like, is wider in application range compared with a traditional synthesis method, and has important synthesis application value.

The application discloses a polyaspartic acid derivative modified by hydroxybenzoyl hydrazine, a preparation method and application thereof, and adopts a graft copolymerization method to introduce the hydroxybenzoyl hydrazine into a peptide chain of polyaspartic acid, and synthesizes three derivatives. 2+ The derivatives can be combined with Ca 2+ Metal ions to generate water-soluble complexes, have good scale inhibition and bacteriostatic performance, and have certain corrosion inhibition effect. In addition, the derivatives have good inhibition effect on escherichia coli, which is the main pollution source in circulating cooling water. The derivatives also have good optical properties, which are convenient for real-time monitoring of the concentration of the derivatives in the circulating cooling water pipeline in cooperation with a fluorescence monitor in industrial production, and optimization of the industrial production process. Therefore, the polyaspartic acid derivative modified by the hydroxybenzoyl hydrazine significantly improves the scale inhibition, corrosion inhibition and bacteriostatic performance, avoids application of a phosphorus-containing compound, and effectively reduces negative influence on the environment.

The invention provides an aluminum ion complex for detecting trace water, a preparation method of the aluminum ion complex and application of a fluorescence sensor, and belongs to the technical field of fluorescence sensors. According to the invention, pyridine-2-formaldehyde and benzoyl hydrazine are subjected to a one-step reaction to synthesize a ligand, the ligand is complexed with aluminum ions to prepare the aluminum ion complex capable of detecting trace water, the preparation method is simple, the raw materials are low in price, and the complex is good in stability. The complex can be used as a fluorescence sensor to show better responsiveness and higher sensitivity to water, the detection process is simple and rapid, and visual qualitative detection can be performed on water; the moisture in the food can be quantitatively detected by utilizing a good linear relationship between the fluorescence emission intensity and the water content. Therefore, the complex prepared by the invention has potential application prospects in the aspect of quantitative analysis of water.

The invention discloses thiazole-2-yl benzoyl hydrazine derivatives as well as a preparation method and application thereof, and belongs to the field of medicinal chemistry. The thiazole-2-yl benzoyl hydrazine derivative shows an excellent broad-spectrum plant pathogenic bacterium resisting effect, has the advantage of being simple in synthesis method, and has important significance on discovery of novel bactericides and overcoming of drug resistance of plant pathogenic fungi.

The invention discloses a 2-(difluoromethyl)-1, 3, 4-oxadiazole derivative as well as a synthesis method and application thereof, and the 2-(difluoromethyl)-1, 3, 4-oxadiazole derivative is obtained by cyclizing benzoyl hydrazine by using economical and efficient (trifluoromethyl) trimethylsilane (TMSCF3) as a bifunctional C1 synthesis source and a difluoromethylation reagent and elemental sulfur as a sustainable sulfur source. The method is mild in reaction condition, does not contain precious metal and harmful byproducts, shows wide compatibility with various functional groups and substrates, and can be used for efficiently preparing derivatives with complex structures at medium to high yield. The strategy of the 1, 2, 4-oxadiazole derivative can provide a modular path for oriented synthesis of fluorine-containing heterocyclic molecules with highly functionalized structures or complex structures.

The invention belongs to the technical field of biological inorganic chemistry, and particularly relates to an imidazolyl Schiff base acylhydrazone ligand, a preparation method of the imidazolyl Schiff base acylhydrazone ligand, an imidazolyl Schiff base acylhydrazone metal drug and application. The invention provides a brand new imidazolyl Schiff base acylhydrazone ligand, the imidazolyl Schiff base acylhydrazone ligand is N '-(5-bromo-2-hydroxybenzylidene)-4-(1-imidazole) benzoyl hydrazine, then the imidazolyl Schiff base acylhydrazone ligand is coordinated with zinc nitrate or europium nitrate, and the imidazolyl Schiff base acylhydrazone metal drug is obtained. A new ligand is obtained by adopting the method disclosed by the invention, a new drug with a clear structure, low toxicity and anticancer activity is prepared by adopting the ligand, and the technical defects of metal drugs and Schiff base drugs in the prior art are overcome.

The invention discloses application of a pyrimidyl hydrazide compound in detection of copper ions or mercury ions and a method for detecting the copper ions or the mercury ions. The pyrimidinyl hydrazide compound has a structural formula shown in the specification. The pyrimidinyl hydrazide compound N '-(2-pyrimidinyl) benzoyl hydrazine prepared by the invention is a dual-optical probe and can be used for detecting low-concentration bivalent copper ions or bivalent mercury ions in a water body.

The application discloses a kind of super-sensitive aluminum ion detection fluorescent probe preparation and application, it is related to converter station valve internal cooling water system aluminum ion fluorescent probe technical field.Probe structure formula is: preparation method is: 4-amino benzhydrazide and 2-hydroxy-1-naphthaldehyde are dissolved in anhydrous ethanol, then reflux, product solution is filtered under vacuum to obtain filtrate, and under the condition of reduced pressure, rotary evaporation dry solvent, obtain benzhydrazide compound based on Schiff base functional group.The application of probe is used to detect the concentration of aluminum ion in sample.The aluminum ion fluorescent probe of the application can be reacted with aluminum ion, and the change of fluorescence spectrum is generated, so that the quantitative detection of aluminum ion is realized.The probe of the application is very sensitive to aluminum ion reaction, so as to facilitate the rapid detection of aluminum ion.The stability of fluorescent probe is good, and then it can be stored for a long time.

The invention belongs to the technical field of probes, and particularly relates to a fluorescence and mass spectrum double-sensibilization labeled probe as well as a preparation method and application thereof. The probe takes benzimidazole as a mother ring and carbohydrazide as a reaction group, and comprises a probe 1 and a probe 2, the probe 1 is iodinated 4-(1, 3-dimethyl-benzimidazole-2-yl) benzoyl hydrazine d0, the chemical structural formula of the probe 1 is shown in the specification, and X is H; the probe 1 is deuterated iodinated 4-(1, 3-dimethyl-benzimidazole-2-yl) benzoyl hydrazine d6, the probe 2 is deuterated iodinated 4-(1, 3-dimethyl-benzimidazole-2-yl) benzoyl hydrazine d6, the chemical structural formula is shown in the specification, and X is D. The method disclosed by the invention can be used for rapidly, accurately and sensitively labeling and detecting the active carbonyl compound, is particularly suitable for separation and detection of trace and trace micromolecular active carbonyl compounds in a complex system, can be used for fluorescence labeling and analysis of various fatty aldehydes in the research fields of life analysis, food analysis and the like, and has a wide application prospect.

The present invention discloses the preparation and application of a benzoylhydrazide perylene diimide electron transport layer. The benzoylhydrazide group is used to coordinately regulate the bay area and amide position of perylene diimide, which effectively solves many common problems faced by electron transport layers, such as poor stability, low electron mobility and energy level mismatch. The benzoylhydrazide group and the aminoalkyl side chain give the material good solution processing performance, strong self-doping characteristics, thickness insensitivity and work function reduction ability. Nitrogen-containing hydrazine and secondary amine groups can form hydrogen bonds with other molecules or ions under certain circumstances, enhance intermolecular interactions and improve the photothermal stability of the material. In addition, after the bay area is modified with the benzoylhydrazide group, it can effectively inhibit molecular aggregation, regulate crystallinity and form a good thin film morphology. Ultimately, the energy conversion efficiency of the organic solar cell prepared with this electron transport layer reached 15.87%.

The application relates to a modified PHA particle and a preparation method thereof, relates to the technical field of high polymer materials, and comprises a polyhydroxyalkanoate matrix resin, modified nanocellulose whiskers, decanedioic acid diphenylhydrazide, epoxy soybean oil and antioxidant 1010; the modified nanocellulose whiskers are nanocellulose whiskers covalently grafted with a short PHA chain on the surface. The application has the effects that a stable interface combination between components and the PHA matrix is achieved, and the crystallinity can be improved to obtain heat resistance while the decrease range of toughness is inhibited.