41 results about "Benzoic hydrazide" patented technology

The invention discloses a chlorine fastness improver, and a preparation method and an application thereof. The chlorine fastness improver comprises, by mass, 1-5% of polyacrylate, 5-48% of a hydrazide derivative, 0.5-6% of a dispersant, and the balance of water. The hydrazide derivative concretely is one or more of octanedioic dihydrazide, azelaic dihydrazide, sebacic dihydrazide, dodecanedioic dihydrazide, isonicotinoylhydrazine, 1,2-diisonicotinic acid hydrazide, 1,2-dimethyl-1,2-dibenzoylhydrazine and isophthalic dihydrazide. The preparation method of the chlorine fastness improver is simple, and the chlorine fastness improver makes chinlon and spandex swimming suit dyed fabrics have the advantages of effectively improved chlorine fastness, small color change, good handle, good chlorine fastness and good water wash resistance.

The invention relates to a 1, 3, 4-oxadiazole neuraminidase inhibitor as well as a preparation method and an application thereof. The inhibitor has a structure as shown in a formula (I). The preparation method specifically comprises the following steps: (1) reacting aniline, chloroacetyl chloride and triethylamine, and performing post-treatment to obtain an intermediate as shown in a formula (II); (2) performing reaction on benzoyl hydrazine, carbon disulfide and potassium hydroxide, and performing post-treatment to obtain an intermediate as shown in a formula (III); and (3) dissolving the intermediate shown in the formula (II) and the intermediate shown in the formula (III) in an organic solvent, reacting, and performing post-treatment to obtain the inhibitor shown in the formula (I). Compared with the prior art, the compound is novel in structure, and experiments show that the compound has good neuraminidase inhibitory activity and can be used for preparing drugs for inhibiting neuraminidase activity.

The invention discloses a benzoyl hydrazine allosteric inhibitor for D-3-phosphoglycerate dehydrogenase and applications of the benzoyl hydrazine allosteric inhibitor, wherein the structure of the benzoyl hydrazine allosteric inhibitor is shown as the formula I, R1, R2, R3, R4, R5, R6 and R7 are the same or different, and respectively represent hydrogen, halogen, nitryl, hydroxyl, amino or substituted amino, alkyl, alkoxy, and benzyloxy or halogen substituted alkyl independently, or the adjacent substituent groups can form a ring. The in-vitro enzymatic activity testing, cell viability testing and mouse heterotransplantation model experiment prove that the compound can specifically inhibit the activity of D-3-phosphoglycerate dehydrogenase, and the growth of cancer cells is delayed by reducing the overexpression of D-3-phosphoglycerate dehydrogenase in the cancer cells. The compound can be used for treating, preventing or inhibiting the tumor diseases including breast cancer, colon cancer, melanoma and non-small cell lung cancer when used independently or in combination with other anti-cancer drugs. The formula I is shown in the description.

The invention provides a modified PGA material with long shelf life and a preparation method thereof. The modified PGA material is prepared from, by weight, 0.2-0.5 part of a chain extender, 70-80 parts of polyglycolic acid, 15-30 parts of filler and 1-5 parts of an anti-blocking agent, wherein the molecular weight of the polyglycolic acid is 100,000-300,000 g / mol, and the melting point of the polyglycolic acid is 200-220 DEG C; the anti-blocking agent is nano silicon dioxide with the specific surface area of less than 200 m<2> / g, the pH value is 3.8-4.3, and the water content is lower than 2%; and the chain extender is a mixture of an epoxy chain extender and sebacic acid dibenzoyl hydrazine. According to the invention, the specific polyglycolic acid is modified by adopting the chain extender and the anti-blocking agent, so that the modified PGA material has a relatively long shelf life; the tensile property and the stiffness are better; the shelf life can reach up to 6 months; the tensile strength is 31 to 33 MPa; the elongation at break is 9.5 to 10 percent; and the stiffness is 1.5 to 2 N.m.

The invention relates to the technical field of synthesis of raw material medicines, and particularly discloses a preparation method of azelastine hydrochloride. The method comprises the following steps: condensing benzoyl hydrazine and 1-methylhexahydroazepine-4-one serving as raw materials, reducing with sodium borohydride, and reacting to obtain a compound 1; preparing a solid intermediate compound 2 from the compound 1 and organic binary weak acid; hydrolyzing the compound 2, and cyclizing with a compound 3 to form a compound 4; and salifying the compound 4 by hydrochloric acid, and separating water by toluene to obtain a compound 5, namely azelastine hydrochloride. The intermediate compound 2 prepared by the invention is a solid, the stability of the intermediate compound 2 is greatly improved compared with that of hydrochloride obtained in other literatures, the intermediate compound 2 is free of hygroscopicity, the purity can reach 99% or above, the quality risk of subsequent bulk drugs can be greatly reduced, and the process production operation space is larger; and the obtained azelastine hydrochloride does not contain water and meets related quality standards, the yield is increased to 80% or above compared with other literatures, and the purity can reach 99% or above.

The invention relates to detection of copper ions and particularly relates to a pyrene derivative and a synthetic method and an application thereof. The pyrene derivative is as shown in a formula I. Abenzoyl hydrazine derivative P obtained by means of an effective synthetic means shows relatively good selectivity on copper ions. Based on an optimized experimental condition, copper ions can be detected. The formula is as shown in the description.

The invention discloses a synthetic method of 2-(5-aryl-1,3,4-oxadiazol-2-yl) aniline compound, the method comprises the following steps: electrolyte, substituted isatin, The substituted benzoylhydrazide, solvent, base, and electrode are respectively added to the electrolytic cell without separation, and the electricity is stirred to react; the solution after the reaction is separated and purified to obtain 2-(5-aryl-1,3,4-oxadi Azol-2-yl) aniline compounds, the preparation process does not require the use of metals and chemical oxidants, the reaction time is short, and the preparation process is green and environmentally friendly.

The invention provides an N-[(1-aryl-3-substituted phenyl-pyrazol-4-yl) methenyl]-2-hydroxyl benzoyl hydrazine compound in a formula (IV) or pharmaceutically acceptable salts and a preparation method thereof. The preparation method comprises the following steps of: diazotizing and reducing arylamine as a raw material, condensing with a product obtained from diazotizing and reducing for Vilsmeier-Haak reaction to obtain 1-aryl-3-phenyl-4-formoxyl pyrazol; and then reacting the 1-aryl-3-phenyl-4-formoxyl pyrazol with salicylyl hydrazine to obtain the N-[(1-aryl-3-substituted phenyl-pyrazol-4-yl) methenyl]-2-hydroxyl benzoyl hydrazine compound shown as the following general formula, wherein each substituent in the formula is defined in the specification. The compound has a good application prospect at the aspect of resisting fungi and Gram negative bacteria.

The invention provides a novel acylhydrazone molecular switch and synthesis thereof and a method for photoinduced slow release of a drug. The molecular switch is formed by condensation of 2-methoxynaphthaldehyde and benzoyl hydrazine. As both sides adjacent to an imine group of hydrazide have groups with high steric hindrance, an E-isomer is easily converted into a Z-isomer under illumination, andthe E-Z isomer conversion efficiency is up to 99 percent, and the quantum yield is up to 89 percent. After being prepared in an amphiphilic molecular switch, the hydrazide can be self-assembled in water to form nano-vesicles, and the vesicles can also undergo E-Z isomer conversion with high conversion rate under the illumination. The vesicles can carry an anticancer drug procarbazine in an inclusion manner, so that the solubility of the drug in water is increased by 225 times. The included procarbazine is released from the vesicles under the illumination.

The present invention designs and synthesizes a kind of sensor molecule based on functionalized double-sided column [5] aromatic hydrocarbon, and this sensor molecule is in DMSO and H 2 In the binary solution of O, a supramolecular self-assembly system is formed through intermolecular hydrogen bond interaction, and the system has almost no fluorescence. When adding isoniazid, benzoylhydrazine, phenylhydrazine, hydrazine hydrate in DMSO‑H 2 In O solution, only the addition of isoniazid can make the fluorescence of the solution turn green, so it can be used for fluorescence selective recognition of isoniazid, and the recognition process is not interfered by other molecules and the detection speed is fast. Based on this result, the fluorescence detection test paper for isoniazid was made to detect isoniazid conveniently and quickly.

The invention relates to the field of organic functional new material chemicals, and discloses a new process technology for preparing m / p-phenylenediamine through rearrangement reaction of m / p-phthalic acid bishydrazide or derivatives thereof for the first time. The m-phenylenediamine (p-phenylenediamine) is a widely-used bulk key fine chemical in the related fields of known dyes, pigments, aramid fibers, medicines and pesticides, building auxiliary materials and the like, and the production process innovation technology of the m-phenylenediamine (p-phenylenediamine) is widely concerned.

A thread-locking anaerobic adhesive and a preparation method thereof belong to the technical field of adhesive preparation. The purpose of the invention is to solve the problems of slow curing of anaerobic adhesives at room temperature and difficulties in curing at low temperatures or when bonding inert materials. The present invention includes anaerobic curing glue and accelerator primer; anaerobic curing glue is mainly made of anaerobic acrylate monomer, accelerator, co-accelerator and initiator, wherein the anaerobic acrylate monomer The parts by weight are 100 parts, the parts by weight of the accelerator are 0.01 to 10 parts, the parts by weight of the accelerator are 0.01 to 10 parts, and the parts by weight of the initiator are 1 to 10 parts; the accelerator primer is mainly composed of Made from ferrocene compounds, benzohydrazide compounds and volatile solvents, wherein the parts by weight of ferrocene compounds are 0.01-5 parts, and the parts by weight of benzohydrazide compounds are 0-5 parts , The parts by weight of the volatile solvent is 100 parts. The invention is used for thread locking anaerobic adhesive.

The invention relates to a calcium ion and zinc ion double-channel rhodamine fluorescent probe as well as a preparation method and application thereof. A structural formula of the calcium ion and zincion double-channel rhodamine fluorescent probe is as follows: the formula is shown in the description; the preparation method comprises the following steps: taking rhodamine B and hydrazine hydrate to react, so as to obtain rhodamine B hydrazide; carrying out reaction on p-aminobenzoate and the hydrazine hydrate; dissolving an obtained product into a solvent and dropwise adding salicylic aldehyde; reacting to obtain salicylic aldehyde-4-aminobenzoyl hydrazide hydrazone; dissolving cyanuric trichloride into the solvent and adding an acid binding agent; dropwise adding a THF (Tetrahydrofuran) solution of the rhodamine B hydrazide into an ice water bath under the protection of nitrogen gas; stirring to obtain RSH; dissolving the RSH and adding the acid binding agent; under the protection ofnitrogen gas, dropwise adding the salicylic aldehyde-4-aminobenzoyl hydrazide hydrazone and reacting to obtain RSHT; dissolving the RSHT and adding the acid binding agent; dropwise adding the hydrazine hydrate under the protection of N2 and reacting to obtain the probe. The fluorescent probe compound provided by the invention has very good selectivity on zinc ions and calcium ions, is convenientlyapplied to environmental applications and has a relatively good utilization effect.