5 results about "Chemiluminescence response" patented technology

This invention provides a photodiode current detection device and method with charge enrichment, enabling real-time acquisition and detection of both strong and weak signals. For strong signals, the real-time photocurrent signal can be directly acquired; for weak signals, the photodiode junction capacitance is used as a charge storage device. By exposing the photodiode to weak light for a period of time, the photocurrent will integrate and accumulate on the junction capacitance, resulting in a stronger accumulated signal, which is then measured, thus achieving weak signal detection. Applying this detection device and method to the chemiluminescence reaction principle for NO gas detection, the charge enrichment mode for detecting low-concentration NO gas yields a high signal-to-noise ratio signal, improving sensitivity. The direct measurement mode for detecting high-concentration NO gas does not affect the upper concentration limit of NO detection. The combination of these two operating modes significantly improves the detection performance and concentration range of the miniaturized NO detector.

This invention belongs to the field of pathogen activity analysis technology. It discloses an optical chemiluminescence trace analysis system for pathogenic bacteria. The system includes: constructing a set of discrete reaction sites of the target pathogenic bacteria on an immobilized capture interface in the sample; performing a chemiluminescence reaction on the set of discrete reaction sites to generate a local chemiluminescence response sequence and a luminescence spatial distribution sequence; obtaining the spatial response trajectory of the target pathogenic bacteria by analyzing the lighting sequence of each discrete reaction site and the expansion and aggregation characteristics in the site's neighborhood; obtaining the pathogenic bacteria activity determination result by analyzing the consistency of continuous luminescence at different discrete reaction sites and the branching and converging characteristics of the outward expansion path in the spatial response trajectory; and outputting a conclusion on the presence of pathogenic bacteria. This invention improves the stability of trace pathogenic bacteria detection and enhances the ability to distinguish weak positives and activity.

A reagent strip and a sample analyzer. The reagent strip comprises: a capture rod, which is coated with a capture agent used for capturing a target analyte in a sample solution to be tested; a label chamber, in which a labeling reagent carrying a label is pre-encapsulated, wherein the labeling reagent can bind to the target analyte; a substrate chamber, in which a signal-generating reagent is pre-encapsulated, wherein the signal-generating reagent can undergo a chemiluminescent reaction with the label to obtain a solution to be tested; and a measurement chamber, in which no liquid is pre-placed, wherein the measurement chamber is used for accommodating at least part of the solution to be tested, such that the solution to be tested in the measurement chamber can be tested by means of an optical signal generated by the chemiluminescent reaction. The test strip and the sample analyzer can improve the testing accuracy.

The application discloses a pair of chiral covalent organic framework materials (CCOFs) based on a dynamic coordination strategy, which are prepared by using Co(II) as a coordination metal center, taking a covalent organic framework Co-TFB-DABP constructed by Co(II) as a main skeleton, and adopting chiral molecules with reversible coordination groups such as carboxyl, sulfydryl and amino for reversible coordination. The chiral covalent organic framework material obtained by the application can catalyze a luminol-hydrogen peroxide chemiluminescence reaction, and when a chiral drug exists, the chiral covalent organic framework material can also have a stereospecific interaction with the chiral drug to produce a differential chemiluminescence response, thereby realizing enantioselective recognition, and therefore, the chiral covalent organic framework material can be used for simply, reliably and highly sensitively detecting chiral drugs such as ibuprofen enantiomers.