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32 results about "Chinese han population" patented technology

Han Nationality. As the largest ethnic group in both China and world wide, Han nationality has a population of about 1.16 billion accounting for 19% of the world's total population.

Chinese population linkage analysis single nucleotide polymorphism (SNP) marker sets and use method and application thereof

The invention relates to Chinese population linkage analysis single nucleotide polymorphism (SNP) marker sets and a use method and application thereof. On the basis of hundreds of millions of Chinese Han population data results in the mass data of the International HapMap Project, medium-density and high-density SNP marker sets for linkage analysis are constructed and optimized, according to the statistical comparisons of multiple parameters such as the linkage disequilibrium, the polymorphism level, the typing success rate, the distribution position and density of genomes and the functional characteristic, and the multi-level selections and experimental verifications. The two marker sets separately contain 3000 and 6001 loci, wherein the 6001 loci contain the 3000 loci. The SNP sets aim at the Han genetic background in design, have high polymorphism in Chinese and can realize the aim of efficiently marking the Chinese family sample genomes. The selection of polymorphic loci is based on the neutral evolution principle, and all the loci are in a non-gene function region, thus the influence of evolution on the gene function can be avoided. Meanwhile, the characteristics that the marking loci have high typing detectability and can uniformly cover the whole genomes can ensure that the whole genomes can be screened completely and new pathogenic genes can be located and found. The two sets of SNP markers are used to customize probes or chips and perform whole-genome genotyping to family samples; and the typing data are used for linkage analysis, and the haplotyping and fine locating of the linkage candidate region are also adopted, thus the use method has more accurate locating result than the traditional method while the cost is lower and the speed is higher. The distribution and coverage of the 6001 SNP marker set in human chromosomes are shown in the appended drawings.
Owner:BEIJING INST OF GENOMICS CHINESE ACAD OF SCI CHINA NAT CENT FOR BIOINFORMATION +1

Susceptible SNP site of NTN1 gene and application thereof

InactiveCN106987635AAids in assessing genetic riskMicrobiological testing/measurementDNA/RNA fragmentationIncomplete bilateral cleft lipRisk allele
The patent is a susceptible SNP site of an NTN1 gene and an application thereof and discloses a genotype of an SNP marker rs4791331 related to assisted diagnosis of non-syndromic cleft lip and palate. Two alleles exist: T and C, wherein the allele T is a risk allele and an application of the allele T in a diagnostic kit for non-syndromic cleft lip and palate is developed. The invention is conductive to comprehensively evaluating the effect of heritable variation in genesis and development and lapse of NSCO of Chinese Han populations and has important meaning in guiding NSOC high risk groups to prevent and screen.
Owner:AFFILIATED STOMATOLOGICAL HOSPITAL OF NANJING MEDICAL UNIV

Biomarkers for predicting venous thromboembolism genetic risk of Chinese Han population, kit and application thereof

The invention provides a group of complete gene locus combinations for predicting the venous thromboembolism genetic risk of Chinese Han people, optimizes the complete gene locus combinations to obtain a simplest gene locus combination, and establishes a model for predicting the venous thromboembolism genetic risk of Chinese Han people, which is relatively high in prediction capability and relatively low in clinical cost. The defect that the current domestic clinical venous thromboembolism risk assessment is lack of a multi-gene collective characterization and genetic risk prediction model and method is overcome, and the method has a wide application prospect.
Owner:西安时代基因医学科技有限公司

THSD7A (Thrombospondin type-1 domain-containing 7A) gene sequence and application thereof to expression change detection and coronary heart disease prediction

The invention relates to the technical field of biology. On one hand, the invention relates to a single nucleotide polymorphism (SNP) site of a coronary heart disease susceptible gene THSD7A (Thrombospondin type-1 domain-containing 7A) and a corresponding composition and a corresponding kit which are used for detecting the SNP site; the invention especially relates to application of a nucleic acid affinity ligand of the SNP site to preparation of a composition which is used for detecting, screening or predicting coronary heart disease susceptibility of Chinese Han population. On the other hand, the invention relates to a corresponding composition and a corresponding kit which are used for detecting the THSD7A gene and further relates to application of a nucleic acid affinity ligand of the THSD7A gene to preparation of the composition for detecting, screening or predicting the coronary heart disease susceptibility of Chinese Han population. The invention provides new further scientific evidence for researching and developing targeted coronary heart disease gene therapy, and a new clue is provided for finding a new coronary heart disease molecule mechanism and developing a new medicine target point and individualized treatment of a coronary heart disease.
Owner:田小利 +1

System and method for establishing age evaluation model based on deep learning technology

The invention discloses a system and method for establishing an age evaluation model based on a deep learning technology. The method comprises the steps of photographing a full-mouth curved-surface fault film of Chinese Han population in the northwest, dividing a curved-surface fault film data set into a training set, a verification set and a test set according to the proportion of 8:1:1, inputting the training set into an EfficitNet-B5 network, carrying out the training of a classifier, and finally, establishing an automatic classification model of 18 years old or not through the performanceof the classifier on the test set. A traditional deep learning model is simplified, a label directly related to an output value is added to an image, a neural network model related to the input imageand the output value is established through a computer algorithm, and then automatic evaluation of the image is achieved; and the whole curved surface fault film is selected as the input image of theneural network instead of being limited to teeth in a certain area, the most comprehensive tooth information is provided for a computer to explore the correlation between the tooth structure and the age, and missing of other structural new information with prompt significance is avoided.
Owner:西安交通大学口腔医院 +1

Thsd7a gene sequence and expression change detection and its application in the prediction of coronary heart disease

The invention relates to the technical field of biology. On one hand, the invention relates to a single nucleotide polymorphism (SNP) site of a coronary heart disease susceptible gene THSD7A (Thrombospondin type-1 domain-containing 7A) and a corresponding composition and a corresponding kit which are used for detecting the SNP site; the invention especially relates to application of a nucleic acid affinity ligand of the SNP site to preparation of a composition which is used for detecting, screening or predicting coronary heart disease susceptibility of Chinese Han population. On the other hand, the invention relates to a corresponding composition and a corresponding kit which are used for detecting the THSD7A gene and further relates to application of a nucleic acid affinity ligand of the THSD7A gene to preparation of the composition for detecting, screening or predicting the coronary heart disease susceptibility of Chinese Han population. The invention provides new further scientific evidence for researching and developing targeted coronary heart disease gene therapy, and a new clue is provided for finding a new coronary heart disease molecule mechanism and developing a new medicine target point and individualized treatment of a coronary heart disease.
Owner:田小利 +1
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