2 results about "Chloroacetates" patented technology

This invention relates to the field of biopharmaceutical technology, specifically to the application of dichloroacetate in the preparation of drugs for preventing high-altitude pulmonary edema. This invention is the first to propose and verify the application of dichloroacetate in preventing high-altitude pulmonary edema. By administering dichloroacetate to mice via drinking water three days in advance as a preventative measure, the degree of pulmonary edema was reduced, providing new drug selection and experimental evidence for the prevention and treatment of altitude sickness.

The invention discloses an alkyl glycoside derivative surfactant and a preparation method thereof.The preparation method of the alkyl glycoside derivative surfactant comprises the steps that firstly, a carboxylation reaction is conducted, specifically, alkyl glycoside and chloroacetate are subjected to a reaction under metal hydroxide, and alkyl glycoside carboxylate is generated; and then carrying out acidification separation: acidifying the alkyl glycoside carboxylate with hydrochloric acid, and separating the obtained product to obtain the alkyl glycoside carboxylic acid. Alkyl glycoside is selected as an initiator of surfactant molecules, and alkyl glycoside carboxylic acid is obtained through carboxylation of alkyl glycoside and chloroacetate. The obtained surfactant has higher surface activity on the basis of the original alkyl glycoside.