6 results about "Chloroacetates" patented technology

The invention discloses a method for preparing a fatty alcohol ether carboxylic acid, and belongs to the technical field of synthesis of anionic nonionic-anionic surfactants in organic chemistry. The method uses a fatty alcohol as a raw material, and under the protection of an inert gas, first uses an organic base to react with a fatty alcohol ether to undergo alkalization, and under the action of a phase transfer catalyst, reacts with chloroacetate to undergo carboxymethylation, and obtains a fatty alcohol ether carboxylic acid through acidification and washing. The method for preparing a fatty alcohol ether carboxylic acid of the invention has a simple process, is easy to control in production, has high product purity, and has stable quality.

The invention belongs to the field of pharmaceutical chemicals, and discloses a preparation method of an anti-HIV (Human Immunodeficiency Virus) drug intermediate, which comprises the following steps: by taking L-phenylalanine as a raw material, synthesizing (3S)-3-(t-butyloxycarboryl) amino-1-chloro-4-phenyl-2-butanone through the steps of amino protection reaction, chloroacetate Claisen condensation reaction and the like. Cheap sodium chloroacetate is adopted as a key reagent for homogeneity of methyl ester, compared with a traditional preparation process, the method has the advantages of being simple in process operation, low in safety risk, small in three-waste emission, low in production cost, high in total yield and the like, used raw materials and intermediate products are low in toxicity, low in price and easy to obtain, industrial production is easier to achieve, and the production efficiency is improved.

This invention relates to the field of biopharmaceutical technology, specifically to the application of dichloroacetate in the preparation of drugs for preventing high-altitude pulmonary edema. This invention is the first to propose and verify the application of dichloroacetate in preventing high-altitude pulmonary edema. By administering dichloroacetate to mice via drinking water three days in advance as a preventative measure, the degree of pulmonary edema was reduced, providing new drug selection and experimental evidence for the prevention and treatment of altitude sickness.

The present invention provides a method for detecting 2 chloroacetic acid residual amount in cetirizine hydrochloride, including: taking cetirizine hydrochloride to be tested and mixing with mobile phase, preparing a test solution; taking 2 chloroacetic acid sodium reference substance and mixing with mobile phase, preparing a reference solution; according to high performance liquid chromatography, using a chromatographic column with octadecylsilane bonded silica gel as a filler, the test solution and the reference solution are respectively injected into a high performance liquid chromatograph. The present invention can effectively detect 2 chloroacetic acid (salt) in cetirizine hydrochloride, meets the detection requirement for 2 chloroacetic acid (salt) residual amount in cetirizine hydrochloride, and is simple to operate, the result is stable and reliable, and the detection accuracy is high.

The invention relates to a method for synthesizing a betaine surfactant from natural oil by a one-pot method and the betaine surfactant, and the method comprises the following steps: 1, placing the natural oil and N, N-dimethyl-1, 3-propane diamine in a reaction container according to a mass ratio of 7.5: 1-0.4: 1 at normal temperature, adding the natural oil and the N, N-dimethyl-1, 3-propane diamine into the reaction container, and reacting for 2-4 hours; the mass of the catalyst is 0.1-0.9% of the total mass of 1, 3-propane diamine; 2, mixing and stirring the reactants, heating to 120-190 DEG C, and carrying out reflux reaction for 5-9 hours; 3, after the reaction is finished, cooling to room temperature, and adding water which is 0.4-4.1 times of the total mass of the mixture, chloroacetate which is 0.6-1.8 times of the total mass of the mixture and a cosolvent which is 0.4-2.3 times of the total mass of the mixture; and 4, carrying out a stirring reflux reaction on the mixture at 60-110 DEG C for 4-8 hours, and after the reaction is finished, cooling to room temperature to obtain a finished product. According to the technical scheme, the synthesis process of the traditional long-chain fatty acid amide betaine is simplified, the process of preparing fatty acid by hydrolyzing natural oil can be reduced, the steps are simple, and the production cost is effectively reduced. Therefore, different types of oil-displacing agents suitable for oil fields are prepared.

The invention discloses an alkyl glycoside derivative surfactant and a preparation method thereof.The preparation method of the alkyl glycoside derivative surfactant comprises the steps that firstly, a carboxylation reaction is conducted, specifically, alkyl glycoside and chloroacetate are subjected to a reaction under metal hydroxide, and alkyl glycoside carboxylate is generated; and then carrying out acidification separation: acidifying the alkyl glycoside carboxylate with hydrochloric acid, and separating the obtained product to obtain the alkyl glycoside carboxylic acid. Alkyl glycoside is selected as an initiator of surfactant molecules, and alkyl glycoside carboxylic acid is obtained through carboxylation of alkyl glycoside and chloroacetate. The obtained surfactant has higher surface activity on the basis of the original alkyl glycoside.