3 results about "Chloroacetates" patented technology

The invention belongs to the field of pharmaceutical chemicals, and discloses a preparation method of an anti-HIV (Human Immunodeficiency Virus) drug intermediate, which comprises the following steps: by taking L-phenylalanine as a raw material, synthesizing (3S)-3-(t-butyloxycarboryl) amino-1-chloro-4-phenyl-2-butanone through the steps of amino protection reaction, chloroacetate Claisen condensation reaction and the like. Cheap sodium chloroacetate is adopted as a key reagent for homogeneity of methyl ester, compared with a traditional preparation process, the method has the advantages of being simple in process operation, low in safety risk, small in three-waste emission, low in production cost, high in total yield and the like, used raw materials and intermediate products are low in toxicity, low in price and easy to obtain, industrial production is easier to achieve, and the production efficiency is improved.

This invention relates to the field of biopharmaceutical technology, specifically to the application of dichloroacetate in the preparation of drugs for preventing high-altitude pulmonary edema. This invention is the first to propose and verify the application of dichloroacetate in preventing high-altitude pulmonary edema. By administering dichloroacetate to mice via drinking water three days in advance as a preventative measure, the degree of pulmonary edema was reduced, providing new drug selection and experimental evidence for the prevention and treatment of altitude sickness.

The invention discloses an alkyl glycoside derivative surfactant and a preparation method thereof.The preparation method of the alkyl glycoside derivative surfactant comprises the steps that firstly, a carboxylation reaction is conducted, specifically, alkyl glycoside and chloroacetate are subjected to a reaction under metal hydroxide, and alkyl glycoside carboxylate is generated; and then carrying out acidification separation: acidifying the alkyl glycoside carboxylate with hydrochloric acid, and separating the obtained product to obtain the alkyl glycoside carboxylic acid. Alkyl glycoside is selected as an initiator of surfactant molecules, and alkyl glycoside carboxylic acid is obtained through carboxylation of alkyl glycoside and chloroacetate. The obtained surfactant has higher surface activity on the basis of the original alkyl glycoside.