30 results about "Cinnoline" patented technology

Belonging to the technical field of photoelectric phosphorescence materials, the invention discloses a preparation method of an iridium complex-containing phosphorescence material and its application in cobalt ion detection. With a general structural formula as shown in formula I, the iridium complex-containing phosphorescence material of the invention can be used for Co<2+> detection and comprises a main ligand and an auxiliary ligand, wherein, the main ligand is a derivative of 3, 4-disubstituted cinnoline, and the auxiliary ligand is a derivative of 15 crown-5 ether dipyridine. By means of the influence of Co<2+> on photo-physical and sensing properties of the iridium complex, the phosphorescence chemical sensor can observe the change of its phosphorescence emission spectrum so as to reach the Co<2+> detection purpose. The phosphorescence chemical sensor of the invention has the advantages of rapid phosphorescence response speed, easy differentiation from a fluorescence background, large range, high identification sensitivity to Co<2+>, good stability, and applicability for Co<2+> detection in various environments, and small interference from other positive ions, etc. Formula I is shown as the following.

The present invention relates to a series of quinoline and cinnoline derivatives of general formula I, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof. And the compounds of general formula I show potent inhibitory activity gainst c-Met kinase. The present invention further relates to the uses of the compounds, pharmaceutically acceptable salts and hydrates for the preparation of medicaments for the treatment and / or prevention of diseases caused by abnormal expression of c-Met kinase, especially for treatment and / or prevention of cancer.

The present invention relates to a series of quinoline and cinnoline derivatives of general formula I, pharmaceutically acceptable salts, hydrates, solvates or prodrugs thereof. And the compounds of general formula I show potent inhibitory activity gainst c-Met kinase. The present invention further relates to the uses of the compounds, pharmaceutically acceptable salts and hydrates for the preparation of medicaments for the treatment and / or prevention of diseases caused by abnormal expression of c-Met kinase, especially for treatment and / or prevention of cancer.

The invention discloses application of a 12H-indazole [2, 1-a] cinnoline-12-ketone compound, and application of the 12H-indazole [2, 1-a] cinnoline-12-ketone compound and pharmaceutically acceptable salts or hydrates of the compound in preparing drugs for treating malignant tumors. The compound has good inhibitory activity especially on PC-3 cells of human prostate cancer and PANC-1 cells of humanpancreatic cancer, can inhibit the proliferation of the above cancer cells in a dose-dependent manner, and has great application prospects.

The invention provides a cinnoline compound PI3K kinase inhibitor as shown in a formula I. In the cinnoline compound PI3K kinase inhibitor, and R1, R2 and R3 are defined in the specification. The invention also provides a pharmaceutical composition of the formula I or the salt thereof, a preparation method of the pharmaceutical composition and application of the pharmaceutical composition to treatment of inflammation caused by overexpression of PI3K kinase, immune diseases, cardiovascular diseases, cancers and other diseases related to PI3K kinase.

The present invention is directed to cinnoline derivatives pharmaceutical compositions containing them and their use in the treatment of disorders and conditions mediated by the CB-1 receptor; more particularly, use in the treatment of disorders and conditions responsive to inverse agonism of the CB-1 receptor. More particularly, the compounds of the present invention are useful in the treatment of metabolic disorders.

The invention provides a pyridopyrazolo cinnoline compound and a preparation method thereof. According to the invention, the pyridopyrazolo cinnoline compound is prepared from a 1-aryl-2-vinyl pyrazolidone compound and an aminopyrazinone compound through a Friedlander reaction and an arylhydroalkylation reaction at the same time under the action of a catalyst and an additive; the preparation method is simple, and the compound has good substrate universality; the pyridopyrazolo cinnoline compound provided by the invention is a brand-new synthetic method provided on the basis of the prior art; and the synthesized pyridopyrazolo cinnoline compound has good antibacterial activity on escherichia coli, pseudomonas aeruginosa, staphylococcus aureus and bacillus subtilis, and a new choice is provided for research and clinical use of antibacterial drugs.

The present invention is directed to heterocyclic fused cinnoline compounds of formula (I) which are M1 receptor positive allosteric modulators and that are useful in the treatment of diseases in Alzheimer's disease, schizophrenia, pain or sleep disorders. The invention is also directed to pharmaceutical compositions comprising the compounds, and to the use of the compounds and compositions in the treatment of diseases mediated by the M1 receptor.

This invention relates to novel Cinnoline -based compounds and their pharmaceutically acceptable salts, tautomers or in vivo- hydrolysable precursors, compositions and methods of use thereof . These novel compounds provide a treatment or prophylaxis of dementia due to Parkinson's disease, dementia due to Alzheimer's disease as well as anxiety disorders, cognitive disorders, and / or mood disorders.

The invention provides a synthetic method for a cinnoline compound and agricultural biological activity thereof, and belongs to the field of organic synthesis. The synthetic method is simple in reaction system, has the advantages of short reaction time, low catalyst dosage and environmental friendliness, and effectively meets the requirement on green chemistry; a reaction can be finished at room temperature by only taking copper sulfate as a catalyst and taking isopropanol as a solvent under illumination condition. According to the technical scheme, the synthetic method comprises the followingsteps: adding a phenylhydrazine compound and a diphenylacetylene compound into a reaction container respectively, and reacting for 1 to 2 hours at room temperature of 20 to 25 DEG C under the light condition of a blue LED (Light-Emitting Diode) lamp under the actions of copper sulfate and isopropanol; adding water and dichloromethane for extracting at the end of the reaction, combining organic layers, and then removing an organic solvent to obtain the cinnoline compound. The cinnoline compound can be applied to the prevention and control of apple ring rot.

The invention relates to a two-oxazoline contained chiral dinuclear ligand with a benzo cinnoline maternal skeleton, and a synthesis method thereof, which belong to the field of chemical technology. The structural formula of the chiral dinuclear ligand I is shown in a formula I. A nitrogen-nitrogen double bond is used as a connection functional group to be connected with bi-metal to be designed into a series of novel chiral dinuclear ligands which can be used for screening more transition metals and applied to more asymmetric catalytic reactions. The synthesis method provided by the invention is simple and has higher yield, the prepared ligand can be coordinated with copper, palladium, silver, rhodium, ruthenium and zinc to form monometallic and bimetallic catalysts applied to many catalytic reactions, and the ligand has a good application prospect.

The invention relates to the new, asymmetrically substituted derivatives of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione and their use as cytostatics exhibiting activity against tumor cells, especially against cells with multidrug resistance (MDR). In particular, the invention concerns derivatives of 2,7-dihydro-3H-dibenzo[de,h]cinnoline-3,7-dione represented by the general formula (I).

The present invention relates to a 3-phenyl-cinnoline analogue or a physiologically acceptable salt thereof, and a cell proliferation inhibitor and an antitumor agent comprising the same, as an active ingredient.

The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

The invention belongs to the technical field of organic synthesis, and in particular relates to a synthetic method of cinnoline salt compound, which is to compound the compound shown in formula (I) and formula (II) under the action of a composite catalytic system composed of metal catalyst-auxiliary ) compound shown in catalyzed cyclization reaction to obtain the cinnoline salt compound shown in formula (III). The invention provides a method for synthesizing a nitrogen-containing internal salt structure. The synthesis method can obtain the target product with good yield through a unique composite catalytic system and mutual synergy and promotion between components and conditions. It provides a new method for the synthesis of nitrogen-containing inner salt compounds, and the corresponding products have certain optical properties, and have good research value and application potential.

Belonging to the technical field of photoelectric phosphorescence materials, the invention discloses a preparation method of an iridium complex-containing phosphorescence material and its application in cobalt ion detection. With a general structural formula as shown in formula I, the iridium complex-containing phosphorescence material of the invention can be used for Co<2+> detection and comprises a main ligand and an auxiliary ligand, wherein, the main ligand is a derivative of 3, 4-disubstituted cinnoline, and the auxiliary ligand is a derivative of 15 crown-5 ether dipyridine. By means of the influence of Co<2+> on photo-physical and sensing properties of the iridium complex, the phosphorescence chemical sensor can observe the change of its phosphorescence emission spectrum so as to reach the Co<2+> detection purpose. The phosphorescence chemical sensor of the invention has the advantages of rapid phosphorescence response speed, easy differentiation from a fluorescence background, large range, high identification sensitivity to Co<2+>, good stability, and applicability for Co<2+> detection in various environments, and small interference from other positive ions, etc. Formula I is shown as the following.

The invention relates to a two-oxazoline contained chiral dinuclear ligand with a benzo cinnoline maternal skeleton, and a synthesis method thereof, which belong to the field of chemical technology. The structural formula of the chiral dinuclear ligand I is shown in a formula I. A nitrogen-nitrogen double bond is used as a connection functional group to be connected with bi-metal to be designed into a series of novel chiral dinuclear ligands which can be used for screening more transition metals and applied to more asymmetric catalytic reactions. The synthesis method provided by the invention is simple and has higher yield, the prepared ligand can be coordinated with copper, palladium, silver, rhodium, ruthenium and zinc to form monometallic and bimetallic catalysts applied to many catalytic reactions, and the ligand has a good application prospect.

The invention belongs to the technical field of organic synthesis, and particularly relates to a synthesis method for a cinnoline salt compound. The synthesis method comprises the following step: carrying out a catalytic cyclization reaction on a compound as shown in a formula (I) and a compound as shown in a formula (II) under the action of a composite catalysis system comprising a metal catalystand assistants so as to obtain the cinnoline salt compound as shown in a formula (III). The invention provides a synthesis method of a nitrogen-containing inner salt structure. According to the synthesis method, target products with good yield can be obtained through a unique composite catalytic system and the mutual cooperation and promotion effect of components and conditions; a brand new method is provided for the synthesis of nitrogen-containing inner salt compounds; and the corresponding products have certain optical properties, and present good research value and application potential.

The invention discloses a preparation method of a nucleic acid fluorescence probe compound AzosD for nuclear staining. The preparation method is characterized by comprising steps as follows: 6-amino-2-methylquinoline is dissolved in acetonitrile, N-bromosuccinimide is added, a reaction is performed, and an intermediate 1 is obtained; the intermediate 1 is dissolved in a water, ethanol and toluenemixed solution, 3-(N,N-dimethylamino)phenylboronic acid, tetrakis(triphenylphosphine)palladium and sodium carbonate are added, refluxing reaction is performed under nitrogen protection, and an intermediate 2 is obtained; the intermediate 2 is dissolved by hydrochloric acid, sodium nitrite is added to the solution under the condition of ice-water bath, pH of the solution is regulated to be neutralby a sodium hydroxide aqueous solution, and 3-methyl-11-(N,N-dimethylamino) cinnoline[3,4-e]quinoline, namely AzosD, is obtained by separation and purification. The compound is good in photobleachingresistant effect, high in biocompatibility, high in enzyme-resistant capacity and high in nuclear targeting, can be applied to specific staining of nucleuses of living cells, and has broad applicationprospect in the fields of long-term monitoring of nuclear morphometry and observation for nuclear morphology change in the cellular physiological process.

The present invention relates to a 3-phenyl-cinnoline compound or a physiologically acceptable salt thereof, and a cell proliferation inhibitor and an antitumor agent comprising the same, as an active ingredient. The cinnoline compounds have the following general formula (1) or (2):

The invention discloses a 5H-quinazoline[3, 2-b] cinnoline-7,13-diketone compound and a preparation method thereof, and belongs to the technical field of synthesis of novel quinazolinone tetracyclic compounds. The technical scheme has the key points that the structure of the 5H-quinazoline[3, 2-b] cinnoline-7, 13-diketone compound is described in the description. The invention also discloses the preparation method of the 5H-quinazoline[3, 2-b] cinnoline-7,13-diketone compound. In a preparation process, starting materials are cheap and available, and the application range of a primer is wide; and in a reaction process, use of a transition metal catalyst is prevented, so that the synthesized 5H-quinazoline[3, 2-b] cinnoline-7,13-diketone compound has potential antitumor activity.

Cinnoline compounds of formula (I):variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the cinnoline compounds.