30 results about "Cinnoline" patented technology

The invention relates to a quinoline shown in the formula I, a cinnoline derivant, and pharmaceutically acceptable salt, hydrate, solvate and prodrug thereof, wherein substituent groups Ar, R1, R2, R3, X, Y, P, Z and n have the meanings given in the specification. The invention also relates to a compound shown in the formula I, which plays a strong role of restraining c-Met kinase, and the usages of the compound and the pharmaceutically acceptable salt and hydrate thereof in preparing drugs for treating diseases caused by c-Met kinase overexpression, particularly in preparing drugs for treating and / or preventing cancer.

A 3-phenyl-cinnoline homologue or a physiologically acceptable salt thereof; and a cytostatic agent or antitumor agent comprising the same as an active constituent.

The invention relates to a two-oxazoline contained chiral dinuclear ligand with a benzo cinnoline maternal skeleton, and a synthesis method thereof, which belong to the field of chemical technology. The structural formula of the chiral dinuclear ligand I is shown in a formula I. A nitrogen-nitrogen double bond is used as a connection functional group to be connected with bi-metal to be designed into a series of novel chiral dinuclear ligands which can be used for screening more transition metals and applied to more asymmetric catalytic reactions. The synthesis method provided by the invention is simple and has higher yield, the prepared ligand can be coordinated with copper, palladium, silver, rhodium, ruthenium and zinc to form monometallic and bimetallic catalysts applied to many catalytic reactions, and the ligand has a good application prospect.

The present invention provides compounds having a structure according to Formula I: (I) or a salt or solvate thereof, wherein R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.

The invention discloses a 12H-indazolo[2,1-a]cinnolin-12-one compound and an application thereof. The structural formula of the 12H-indazolo[2,1-a]cinnolin-12-one compound is represented by formula I,and the compound and its pharmaceutically acceptable salts or hydrates are applied to the preparation of drugs for treating malignant tumors. The compound particularly has good inhibitory activity onhuman prostate cancer PC-3 cells and human pancreatic cancer PANC-1 cells, can inhibit proliferation of the cells in a dose-dependent manner, and has great application prospects. The compound has theadvantages of simple preparation method, cheap and easily available raw materials, low production cost, and convenience in industrial production.

The invention belongs to the technical field of organic synthesis, and in particular relates to a synthetic method of cinnoline salt compound, which is to compound the compound shown in formula (I) and formula (II) under the action of a composite catalytic system composed of metal catalyst-auxiliary ) compound shown in catalyzed cyclization reaction to obtain the cinnoline salt compound shown in formula (III). The invention provides a method for synthesizing a nitrogen-containing internal salt structure. The synthesis method can obtain the target product with good yield through a unique composite catalytic system and mutual synergy and promotion between components and conditions. It provides a new method for the synthesis of nitrogen-containing inner salt compounds, and the corresponding products have certain optical properties, and have good research value and application potential.

The invention discloses a cinnoline ring contained ether compound. The structure of the ether compound is represented by general formula I shown in the specification, wherein R1 and R2 in the general formula I are respectively selected from hydrogen, halogens or Q, at least one of the R1 and the R2 is Q, and Q is defined in the specification; and R3, R4, R5 and R6 can be same or different, and are respectively selected from hydrogen, the halogens, a cyan group, a nitro group, C1-C3 alkyl groups, C1-C3 halogenated alkyl groups, C1-C3 alkoxy groups or C1-C3 halogenated alkoxy groups. The compound of the general formula I has an excellent insecticidal activity and can be used for controlling agricultural or forestall insect attack.

The invention discloses a conjugated polymer containing benzo[c]cinnoline, its synthesis method and application. The structural formula of the conjugated polymer based on benzo[c]cinnoline mentioned in the present invention. The most common organic solar cell (OPVs) device (device structure is: ITO / PEDOT:PSS / Polymer:PC) prepared by the conjugated polymer based on benzo[c]cinnoline of the present invention 71 BM / LiF / Al), with its high open circuit voltage, wide and strong spectral response range, ideal fill factor, high short-circuit current density, and high energy conversion efficiency of 7.92%, fully demonstrated the potential and potential of this type of polymer in OPVs. Good application prospects.

Belonging to the technical field of photoelectric phosphorescence materials, the invention discloses a preparation method of an iridium complex-containing phosphorescence material and its application in cobalt ion detection. With a general structural formula as shown in formula I, the iridium complex-containing phosphorescence material of the invention can be used for Co<2+> detection and comprises a main ligand and an auxiliary ligand, wherein, the main ligand is a derivative of 3, 4-disubstituted cinnoline, and the auxiliary ligand is a derivative of 15 crown-5 ether dipyridine. By means of the influence of Co<2+> on photo-physical and sensing properties of the iridium complex, the phosphorescence chemical sensor can observe the change of its phosphorescence emission spectrum so as to reach the Co<2+> detection purpose. The phosphorescence chemical sensor of the invention has the advantages of rapid phosphorescence response speed, easy differentiation from a fluorescence background, large range, high identification sensitivity to Co<2+>, good stability, and applicability for Co<2+> detection in various environments, and small interference from other positive ions, etc. Formula I is shown as the following.

A 3-phenyl-cinnoline homologue or a physiologically acceptable salt thereof; and a cytostatic agent or antitumor agent comprising the same as an active constituent.

The invention discloses the application of a 12H-indazol[2,1-a]cinnoline-12-ketone compound, the 12H-indazol[2,1-a]cinnoline-12-ketone compound The application of the pharmaceutically acceptable salt or hydrate thereof in the preparation of a medicine for treating malignant tumors. The compound has good inhibitory activity especially on human prostate cancer PC-3 cells and human pancreatic cancer PANC-1 cells, and can inhibit their proliferation in a dose-dependent manner, and has great application prospects.

The present invention relates to a 3-phenyl-cinnoline compound or a physiologically acceptable salt thereof, and a cell proliferation inhibitor and an antitumor agent comprising the same, as an active ingredient. The cinnoline compounds have the following general formula (1) or (2):

The invention discloses a 5H-quinazoline[3, 2-b] cinnoline-7,13-diketone compound and a preparation method thereof, and belongs to the technical field of synthesis of novel quinazolinone tetracyclic compounds. The technical scheme has the key points that the structure of the 5H-quinazoline[3, 2-b] cinnoline-7, 13-diketone compound is described in the description. The invention also discloses the preparation method of the 5H-quinazoline[3, 2-b] cinnoline-7,13-diketone compound. In a preparation process, starting materials are cheap and available, and the application range of a primer is wide; and in a reaction process, use of a transition metal catalyst is prevented, so that the synthesized 5H-quinazoline[3, 2-b] cinnoline-7,13-diketone compound has potential antitumor activity.

Cinnoline compounds of formula (I), variations thereof, and their use as inhibitors of HPK1 (hematopoietic kinase 1) are described. The compounds are useful in treating HPK1-dependent disorders and enhancing an immune response. Also described are methods of inhibiting HPK1, methods of treating HPK1-dependent disorders, methods for enhancing an immune response, and methods for preparing the cinnoline compounds.