1 results about "Colonic Carcinoma" patented technology

The application discloses a chiral imide derivative and a preparation method and application thereof. A simple synthesis method of NHC catalyzed imine and MBH carbonate is designed, and a chiral imide derivative is efficiently constructed by one-step method. Biological activity evaluation is carried out on the compounds, and the inhibition rates of all the compounds on three tumor cells, human lung cancer cells A549, human colon cancer cells LOVO and SW620, are enhanced with the increase of concentration, wherein, the compounds 3g, 3i, 3j and 3o show better inhibition effect on the three tumor cells, the inhibition rate of the compound 3g on the A549 cells reaches 50% at a concentration of 12.5 μg / ml, and the inhibition rates of the compounds 3i, 3j and 3o on the A549 cells are all above 70% at a concentration of 50.0 μg / ml, and the inhibition rate of the compound 3j on the A549 cells reaches 85.8%, so the compound 3j has the value of further development and research.