5 results about "Diazoacetic ester" patented technology

The invention discloses a method for preparing cyclopentane [c] quinoline by using visible light / molecular iodine dual catalysis, and relates to the technical field of chemical synthesis. Specifically, diazoacetate compounds and 1, 7-eneyne are used as substrates, fac-Ir (planar-tri (2-phenylpyridine) iridium complex) and molecular iodine are used as catalysts, CH3CN is used as a solvent, and a cyclopentane [c] quinoline skeleton is synthesized under the protection of nitrogen atmosphere and irradiation of a 15w LED blue light lamp. The preparation method provided by the invention has very excellent substrate compatibility, can also be well compatible with diazoacetate compounds modified by natural products, enriches the diversity of substrates synthesized by a cyclopentane [c] quinoline skeleton, and provides a new way for preparation of the cyclopentane [c] quinoline skeleton.

A fluorine-free carbon chain hydrophobic fabric, and its preparation method and application. A fabric is sequentially soaked in an alkali liquor and an acid liquor to obtain a pretreated fabric; the pretreated fabric then reacts with bromoacetyl bromide to obtain a treated fabric; the treated fabric then reacts with 1,2-bis(p-toluenesulfonyl) hydrazine to obtain a diazotized fabric; the diazotized fabric reacts with a diazoacetate monomer to obtain a fluorine-free carbon chain hydrophobic fabric; and the diazoacetate monomer is butyl diazoacetate, hexyl diazoacetate, octyl diazoacetate, dodecyl diazoacetate, tetradecyl diazoacetate or octadecyl diazoacetate. According to the scheme, diazoacetate is used as a monomer, and different fiber grafting modification processes are used, so as to form different structures on the fiber surface; and the comprehensive properties such as thermal stability, air permeability and breaking strength of the finished fabric are tested, the heat resistance and breaking strength of the finished fabric are reduced, and the air permeability is good.

The present application relates to a kind of methods for calculating the reaction energy of iron-catalyzed o-alkynyl benzoyl diazoacetate metathesis to generate indeno [1,2-c] furan, comprising the following steps: selecting target reaction, designing reaction mechanism cycle diagram;According to the reaction mechanism cycle diagram, the molecular structure model of the intermediate, transition state involved in the reaction process is built;The multiple spin state geometry of each intermediate, transition state under gas phase condition is optimized, and the molecular geometry, electronic energy and gibbs free energy correction value are obtained;Based on the geometry obtained under gas phase condition, single-point energy calculation is carried out in solvent condition, and single-point energy is obtained;The gibbs free energy correction value obtained in step S3 is combined with the single-point energy obtained in step S4, to calculate the gibbs free energy of each intermediate and transition state under solvent condition, and then the energy barrier of each step of reaction and the rate-determining step of reaction are obtained.The method has theoretical reference value for experiment, and can reduce the manpower and material resources required by traditional experiment.

The invention provides a synthesis method of an intermediate for synthesizing 2, 3-dimethyl cyclopropyl formic acid, and the structural formula is as follows: # imgabs0 #. The synthesis method comprises the following steps: (1) reacting diazoacetate G with cis-2-butene to obtain a mixture H; (2) hydrolyzing the mixture H to obtain a cis-trans carboxylic acid mixture I; (3) reacting the mixture I with a chlorination reagent to obtain an acyl chloride intermediate J; (4) reacting the acyl chloride intermediate J with benzyl alcohol to obtain a mixture B; and (5) carrying out column chromatography separation on the mixture B to obtain (1 alpha, 2 beta, 3 beta)-2, 3-dimethyl cyclopropyl benzyl formate C and (1 alpha, 2 alpha, 3 alpha)-2, 3-dimethyl cyclopropyl benzyl formate D. The other synthetic method comprises the following steps: reacting benzyl diazoacetate with cis-2-butene to obtain a mixture B, and then separating through column chromatography to obtain a pure compound C and a pure compound D. The preparation method has the advantages of few reaction steps, simple and easily available raw materials, and easy industrial production.

The invention relates to the field of synthesis of pesticide intermediates, in particular to a preparation method of a pyraflufen-ethyl beta-keto ester intermediate, corresponding beta-keto ester 3 is generated through reaction of a compound 1 shown in the specification and diazoacetate 2, and the beta-keto ester 3 is a key intermediate of a pesticide pyraflufen-ethyl. The method provided by the invention realizes the conversion of aldehyde to beta-keto ester in one step, simplifies the route, avoids the use of expensive reagents, reduces the cost, is simple in three wastes, feeding operation and post-treatment, overcomes the defects in the prior art, and has industrial value. In the formula, R1 is equal to-CH2CN or-CH2COOEt, R2 is equal to-CH2CN or-CH2COOEt; and R2 is equal to-CH3 or-CH2CH3.