6 results about "Differentiation Antigens" patented technology

The invention belongs to the technical field of biomedical detection, and discloses a blood cell analysis system based on image flow cytometry, which comprises a cell staining module, the dyeing module simultaneously comprises a first fluorescent probe capable of being specifically combined with components in a cell nucleus or enriched in the cell nucleus, a second fluorescent probe capable of being specifically combined with cell nucleus DNA and a third fluorescent probe capable of being specifically combined with a blood cell differentiation antigen; an image flow cytometer; and the image processing module is used for calculating the kernel detection rate and / or the average kernel number. According to the present invention, the combination of the specific types of the cell staining dyes is adopted, the image flow cytometry is matched, and the optimized multi-dimensional fluorescence staining combination and the matched automatic image analysis process are adopted to achieve the synchronous, high-throughput and accurate quantitative analysis of the blood cell immune phenotype and the cell morphology key characteristics at the single cell level;

This invention discloses a quality control sample for flow cytometry detection of leukocyte differentiation antigen CD34 and its preparation method, relating to the field of flow cytometry quality control technology. The preparation method of this invention successfully prepared a quality control sample for flow cytometry detection of leukocyte differentiation antigen CD34. The quality control sample for flow cytometry detection of leukocyte differentiation antigen CD34 provided by this invention, as the first domestic quality control sample for CD34 flow cytometry counting, fills a gap in this product field in China. This quality control sample has performance close to imported reagents, uses the same operating method, and does not incur additional learning costs; furthermore, the product's shelf life can be stably maintained at 45–50 days, and its usage cost is far lower than imported quality control samples.

This specification provides, in particular, an antibody-binding domain for the differentiation antigen group 3 T cell receptor (CD3), an antibody-binding domain for the epidermal growth factor receptor (EGFR), a cleavable linker sequence, and a protease-activatable bispecific fusion protein, such as a protease-activatable T cell engager, as well as therapeutic uses and methods.

This specification provides human differentiation antigen group 6 (CD6) binding molecules and nucleic acid sequences encoding such molecules. In certain embodiments, this specification provides a first single-monomer variable antibody domain (SMVAD) comprising a specific CDR and, optionally, a human CD6 binding molecule (e.g., a nanobody) having a second single-monomer variable antibody domain, and a method for treating T-cell-related diseases (e.g., cancer, e.g., T-cell lymphoma) using such molecules. In certain embodiments, the SMVAD comprises a camelid, human, or humanized framework region.

This specification provides, in particular, an antibody-binding domain for the differentiation antigen group 3 T cell receptor (CD3), an antibody-binding domain for the epidermal growth factor receptor (EGFR), a cleavable linker sequence, and a protease-activatable bispecific fusion protein, such as a protease-activatable T cell engager, as well as therapeutic uses and methods.

The present application relates to the field of vaccines, in particular to an engineered myeloid cell and a preparation method and use thereof. The present application provides an antigen-modified gel, an engineered myeloid cell and use thereof, wherein the antigen-modified gel comprises a plurality of immunostimulants and tumor antigens, attracts monocytes to migrate into and differentiate into antigen-presenting cells, and the activated and antigen-loaded monocytes further migrate out of the gel to lymph nodes, and can efficiently induce an anti-tumor immune response of lymphocytes such as T cells.