The invention discloses an estradiol production device. The device comprises a reaction kettle, an elutriation kettle, a centrifuge, a concentrating kettle, a decolorization kettle and a drying device, wherein the drying device comprises an outer cylinder, a drying cylinder and an inner cylinder, a motor is arranged on the bottom surface of the outer cylinder, and an exhaust fan blade, a cylinder-type impeller and a vortex impeller are arranged on the rotating shaft of the motor; the exhaust fan blade is disposed between the drying cylinder and the bottom surface of the outer cylinder, the cylinder-type impeller is disposed between the drying cylinder and the inner cylinder, and the vortex impeller is arranged at the bottom of the inner cylinder; an infrared heating tube is arranged on thetop surface of the inner cylinder, an air purifying ring is arranged at the upper end of a sandwich cavity of the outer cylinder, and a material inlet is formed in the center of a top plate; a sliding rod is arranged at the edge of the material inlet, a tray is connected to the lower end of the sliding rod, and a screw rod is arranged on the side edge of the material inlet; a screw sleeve is arranged on the screw rod, a gear ring which is arranged on the screw sleeve is meshed with a drive gear, and the drive gear is connected with a drive motor; and the lower end of the screw rod is connected with the tray, and a cover plate is connected with tops of the sliding rod and the screw rod. Through the estradiol production device, the preparation time of an intermediate product during production of estradiol can be reduced, and rapid high-quality production of estradiol can be realized.