The present invention relates to novel
benzopyran ER-β
agonist compounds, pharmaceutical compositions thereof, and use of these compounds to treat a ER-β mediated
disease such as
nocturia, obstructive
uropathy, benign prostatic hypertrophy,
obesity,
dementia, hypertension, incontinence, colon
cancer,
prostate cancer,
infertility, depression,
leukemia,
inflammatory bowel disease, and
arthritis. Formula (I), wherein G is —O—, —S(O)n, —CF2—, —C(O)—, —CR1H— or —CR2(OH)—; R is halo, (C1-C4)
alkyl or R3—(CH2)m—; R1 is F, hydroxyl, cyano,
trifluoromethyl, (C1-C4)
alkyl, (C2-C4)alkenyl, (C2-C4)alkynyl, (C1-C4)alkoxy, (C1-C4)alkylcarbonyloxy or benzyl; R2 is
trifluoromethyl or (C1-C4)
alkyl; R3 is cyano, hydroxyl, (C2-C4)alkenyl, (C1-C4)alkoxy or (C1-C4)alkoxycarbonyl; n is 0, 1 or 2; and m is 0, 1 or 2; and pharmaceutically acceptable salts thereof.