The invention relates to the technical field of epidemic prevention and control, and discloses a high-protection mask with a replacement reminding function. The high-protection mask comprises a mask body, a fixing piece is fixed to the wall of the mask body, the fixing piece is fixedly connected with a reminding device, the reminding device is provided with a control chip and an airflow electronicswitch, and the output end of the airflow electronic switch is connected with the input end of the control chip through a wire. According to the high-protection mask, the airflow electronic switch isarranged, when the mask is worn, a user exhales, the airflow electronic switch is automatically turned on after receiving exhaled airflow, and then timing is started; and according to the control chip, the user can record the use time of one single mask, the rejection time is set on the control chip during factory production, and when the service life of the used mask is over, an alarm gives outa prompt to remind the user to replace the mask, so that the service life of the mask is utilized to the maximum extent, the personal protection of the user is improved, and prevention and control ofepidemic situations are facilitated.