39 results about "Fluoroacetates" patented technology

The invention discloses a method and device for preparing methyl fluoroacetate. The preparation method comprises the following steps of (1) adding potassium fluoride, a solvent and a catalyst in a reaction kettle, stirring and heating; (2) adding methyl chloroacetate into the reaction kettle continuously to carry out reaction when the temperature rises to a reaction temperature, performing two-stage condensation on a mixed gas generated by the reaction, wherein methyl chloroacetate in the mixed gas is condensed to form a liquid in a first stage and returned to the reaction kettle to participate the reaction continuously and methyl fluoroacetate is condensed to form a liquid in a second stage to form the product, according to difference of boiling temperatures. According to the preparation method provided by the invention, the obtained methyl fluoroacetate product has high purity; and the technology process is simple and reasonable, has relatively high reaction conversion rate and yield, can be operated and controlled easily, and is suitable for large-scale production.

The invention belongs to the technical field of chemical synthesis of medicines and relates to a preparation method of 5-flucytosine. The preparation method comprises the following steps: utilizing ethyl formate and methyl chloroformate to synthesize 2-chloro-3-oxo methyl propionate, then utilizing oxymethylisourea to close rings to obtain pyrimidine rings, utilizing potassium fluoride to substitute chlorine on the pyrimidine rings, utilizing phosphorus oxytrichloride to substitute hydroxyl groups on the pyrimidine rings, then adding ammonia water to lead chloride to be substituted with aminogroups, and hydrolyzing under an acid condition to obtain a product, namely the 5-flucytosine. The preparation method has the beneficial effects that the methyl chloroacetate is adopted for substituting methyl fluoroacetate to be used as a synthetic raw material of the 5-flucytosine, so that the use of highly-toxic chemicals such as the methyl fluoroacetate is avoided; simultaneously, since the price of the methyl chloroacetate is much lower than the price of the methyl fluoroacetate, the production cost can be saved; by utilization of the synthetic route provided by the invention, the higher-purity 5-flucytosine can be prepared without need of complex aftertreatment steps; simultaneously, the preparation method has higher overall yield and obvious industrial value and is worthy of being promoted and used on a large scale.

Provided are acetaic abiraterone trifluoroacetate, a preparation method and an application of same. The acetaic abiraterone trifluoroacetate is obtained through a salt-forming reaction between acetaic Abiraterone and trifluoroacetic acid. The acetaic abiraterone trifluoroacetate undergoes self-purification through recrystallization, and dissociation and recrystallization are performed on the purified abiraterone acetate trifluoroacetate, so that the obtained acetaic abiraterone has a high purity, a high yield and stable quality, and is capable of meeting the requirement for mass production of acetaic abiraterone.